Search of human proteins with 104294888

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor
[Homo sapiens]
         (1363 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [...  2782   0.0  
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [...  2643   0.0  
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]   1042   0.0  
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [...   924   0.0  
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [...   361   2e-99
gi|5453870 platelet-derived growth factor receptor alpha precurs...   357   4e-98
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...   342   1e-93
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene...   342   1e-93
gi|27262659 colony stimulating factor 1 receptor precursor [Homo...   337   4e-92
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [...   329   1e-89
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]             326   8e-89
gi|4505683 platelet-derived growth factor receptor beta precurso...   315   2e-85
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   303   1e-81
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   302   1e-81
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   300   8e-81
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   300   8e-81
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   300   8e-81
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   299   1e-80
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   299   1e-80
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   299   1e-80
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   299   1e-80
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   296   1e-79
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   294   4e-79
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   293   8e-79
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   293   8e-79
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   292   1e-78
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   292   1e-78
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   290   5e-78
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   287   4e-77
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   284   5e-76

>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
            sapiens]
          Length = 1363

 Score = 2782 bits (7211), Expect = 0.0
 Identities = 1363/1363 (100%), Positives = 1363/1363 (100%)

Query: 1    MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA 60
            MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA
Sbjct: 1    MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA 60

Query: 61   WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI 120
            WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI
Sbjct: 61   WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI 120

Query: 121  EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG 180
            EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG
Sbjct: 121  EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG 180

Query: 181  QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL 240
            QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL
Sbjct: 181  QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL 240

Query: 241  ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV 300
            ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV
Sbjct: 241  ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV 300

Query: 301  SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA 360
            SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA
Sbjct: 301  SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA 360

Query: 361  YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV 420
            YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV
Sbjct: 361  YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV 420

Query: 421  PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ 480
            PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ
Sbjct: 421  PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ 480

Query: 481  DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV 540
            DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV
Sbjct: 481  DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV 540

Query: 541  GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD 600
            GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD
Sbjct: 541  GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD 600

Query: 601  AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS 660
            AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS
Sbjct: 601  AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS 660

Query: 661  HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE 720
            HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE
Sbjct: 661  HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE 720

Query: 721  KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV 780
            KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV
Sbjct: 721  KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV 780

Query: 781  GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF 840
            GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF
Sbjct: 781  GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF 840

Query: 841  PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL 900
            PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL
Sbjct: 841  PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL 900

Query: 901  IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF 960
            IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF
Sbjct: 901  IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF 960

Query: 961  RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ 1020
            RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ
Sbjct: 961  RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ 1020

Query: 1021 VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW 1080
            VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW
Sbjct: 1021 VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW 1080

Query: 1081 MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA 1140
            MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA
Sbjct: 1081 MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA 1140

Query: 1141 TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200
            TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS
Sbjct: 1141 TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200

Query: 1201 QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM 1260
            QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM
Sbjct: 1201 QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM 1260

Query: 1261 TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRR 1320
            TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRR
Sbjct: 1261 TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRR 1320

Query: 1321 RPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY 1363
            RPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY
Sbjct: 1321 RPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY 1363


>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
            sapiens]
          Length = 1298

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1297/1297 (100%), Positives = 1297/1297 (100%)

Query: 1    MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA 60
            MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA
Sbjct: 1    MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA 60

Query: 61   WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI 120
            WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI
Sbjct: 61   WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI 120

Query: 121  EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG 180
            EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG
Sbjct: 121  EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG 180

Query: 181  QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL 240
            QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL
Sbjct: 181  QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL 240

Query: 241  ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV 300
            ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV
Sbjct: 241  ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV 300

Query: 301  SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA 360
            SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA
Sbjct: 301  SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA 360

Query: 361  YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV 420
            YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV
Sbjct: 361  YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV 420

Query: 421  PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ 480
            PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ
Sbjct: 421  PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ 480

Query: 481  DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV 540
            DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV
Sbjct: 481  DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV 540

Query: 541  GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD 600
            GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD
Sbjct: 541  GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD 600

Query: 601  AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS 660
            AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS
Sbjct: 601  AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS 660

Query: 661  HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE 720
            HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE
Sbjct: 661  HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE 720

Query: 721  KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV 780
            KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV
Sbjct: 721  KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV 780

Query: 781  GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF 840
            GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF
Sbjct: 781  GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF 840

Query: 841  PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL 900
            PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL
Sbjct: 841  PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL 900

Query: 901  IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF 960
            IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF
Sbjct: 901  IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF 960

Query: 961  RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ 1020
            RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ
Sbjct: 961  RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ 1020

Query: 1021 VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW 1080
            VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW
Sbjct: 1021 VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW 1080

Query: 1081 MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA 1140
            MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA
Sbjct: 1081 MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA 1140

Query: 1141 TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200
            TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS
Sbjct: 1141 TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200

Query: 1201 QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM 1260
            QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM
Sbjct: 1201 QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM 1260

Query: 1261 TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGF 1297
            TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGF
Sbjct: 1261 TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGF 1297


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score = 1042 bits (2694), Expect = 0.0
 Identities = 592/1333 (44%), Positives = 790/1333 (59%), Gaps = 71/1333 (5%)

Query: 1    MQRGAALCLRLWLCLGLLDGLVS--GYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLE 58
            MQ    L + LWLC+      V     S+  P L+I ++   I    +L I+CRGQ  L+
Sbjct: 1    MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD 60

Query: 59   WAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKA 118
            W WP  Q         SE    V +C       +CK L + +V  NDTG+Y C+Y+    
Sbjct: 61   WLWPNNQSG-------SEQRVEVTECSDG---LFCKTLTIPKVIGNDTGAYKCFYR---- 106

Query: 119  RIEGTTAASSYVFVRDFEQPFINKPDT------LLVNRKDAMWVPCLVSIPGLNVTL--R 170
              E   A+  YV+V+D+  PFI           +  N+   + +PCL SI  LNV+L  R
Sbjct: 107  --ETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCAR 164

Query: 171  SQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELY 230
                   PDG  + WD ++G  + + ++  A  + CE    D+ + S  ++V + G  +Y
Sbjct: 165  YPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIY 224

Query: 231  DIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTE 290
            D+ L P   +EL VGEKLVLNCT   E N G+ F+W+YP  + +  K V      Q+ +E
Sbjct: 225  DVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSE 284

Query: 291  LS---SILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA 347
            +    S LTI  V++ D G Y C A++G+   + ST V VHE PF++       ++EAT 
Sbjct: 285  MKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATV 344

Query: 348  GDELVKLPVKLAAYPPPEFQWYKDGKALSGRHS---PHALVLKEVTEASTGTYTLALWNS 404
            G E V++P K   YPPPE +WYK+G  L   H+    H L + EV+E  TG YT+ L N 
Sbjct: 345  G-ERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNP 403

Query: 405  AAGLRRNISLELVVNVPPQIHEKEASSP-SIYSRHSRQALTCTAYGVPLPLSIQWHWRPW 463
             +  +++  + LVV VPPQI EK   SP   Y   + Q LTCT Y +P P  I W+W+  
Sbjct: 404  ISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLE 463

Query: 464  TPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVI 523
              C     +++           C +WR+V      N IE        +EGKNKTVS LVI
Sbjct: 464  EECANEPSQAVSVTNPYP----CEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVI 519

Query: 524  QNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSY 583
            Q ANVSA+YKC   NKVG+ ER+I F+VT  P+   I  +P  +  E + V L C AD  
Sbjct: 520  QAANVSALYKCEAVNKVGRGERVISFHVTRGPE---ITLQPDMQPTEQESVSLWCTADRS 576

Query: 584  KYEHLRWYRLNLSTLHDAHGNPLLLDCKNVH----LFATPLAASLEEVAPGARHATLSLS 639
             +E+L WY+L    L    G      CKN+     L AT  + S  ++        L + 
Sbjct: 577  TFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI--------LIME 628

Query: 640  IPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQC 699
            +   + + +G YVC  QDR++  +HC  + L+V    AP +T NL +   ++ +S+E+ C
Sbjct: 629  LKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSC 688

Query: 700  LVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNS 759
              +G   P I+W+KD   L E SG+ L D N+ L+I+RVR+ED G Y C  C+  GC   
Sbjct: 689  TASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKV 748

Query: 760  SASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDP 819
             A   +EG+++K ++EI+ILVGT VIA+FFW+LL++I   ++R    ++KTGYLSI+MDP
Sbjct: 749  EAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDP 808

Query: 820  GEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVK 879
             E+PL+E CE L YDAS+WEFPR+RL LG+ LG GAFG+V+EA AFGI K ++C TVAVK
Sbjct: 809  DELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVK 868

Query: 880  MLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFL 939
            MLKEGAT SEHRALMSELKILIHIG+HLNVVNLLGACTKP GPLMVIVEFCK+GNLS +L
Sbjct: 869  MLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL 928

Query: 940  RAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRAS--- 996
            R+KR+ F P   K    R + +  V    +D +R    D +  ++ S + G     S   
Sbjct: 929  RSKRNEFVPYKTKGARFR-QGKDYVGAIPVDLKR--RLDSITSSQSSASSGFVEEKSLSD 985

Query: 997  --PDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKIC 1054
               ++  EDL+   LT+E L+CYSFQVA+GMEFLASRKCIHRDLAARNILLSE +VVKIC
Sbjct: 986  VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1045

Query: 1055 DFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP 1114
            DFGLARDIYKDPDYVRKG ARLPLKWMAPE+IFD+VYT QSDVWSFGVLLWEIFSLGASP
Sbjct: 1046 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1105

Query: 1115 YPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQ 1174
            YPGV+I+EEFC+RL++GTRMRAP+  TP + + ML+CW G+P  RP FSELVE LG+LLQ
Sbjct: 1106 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165

Query: 1175 GRGLQEEEEVCMAPRS-SQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNW 1233
                Q+ ++  + P S + S EE S   + T  +   + +    P           Y N 
Sbjct: 1166 ANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDP--------KFHYDNT 1217

Query: 1234 VSFPGCLARGAETRGSSRMKTFEEFPM-TPTTYKGSVDNQTDSGMVLASEEFEQIESRHR 1292
                  L           +KTFE+ P+  P       DNQTDSGMVLASEE + +E R +
Sbjct: 1218 AGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTK 1277

Query: 1293 QESGFSCKGPGQN 1305
                F    P ++
Sbjct: 1278 LSPSFGGMVPSKS 1290


>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1338

 Score =  924 bits (2389), Expect = 0.0
 Identities = 530/1300 (40%), Positives = 749/1300 (57%), Gaps = 77/1300 (5%)

Query: 4    GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
            G  LC  L  CL LL G  SG  +  P L++    H++  G +L + CRG+   +W+   
Sbjct: 8    GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62

Query: 64   AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
                P    K+SE   + +   G + + +C  L L+   AN TG Y C Y  +    +  
Sbjct: 63   ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119

Query: 124  TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
            T ++ Y+F+ D  +PF+      P+ + +     + +PC V+ P + VTL+      L P
Sbjct: 120  TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179

Query: 179  DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
            DG+ ++WD R+G ++S     +   L CE T     + +N +L H   N + D+Q+   +
Sbjct: 180  DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238

Query: 239  SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
             ++LL G  LVLNCT     N+ V   W YP ++ +R      RR  Q+++  +   S+L
Sbjct: 239  PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296

Query: 296  TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
            TI  +   D G Y C+  +G      +T V +++  FI+V+  K  +LE  AG    +L 
Sbjct: 297  TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356

Query: 356  VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
            +K+ A+P PE  W KDG   + + + +     +L++K+VTE   G YT+ L    + + +
Sbjct: 357  MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416

Query: 411  NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
            N++  L+VNV PQI+EK  SS   P++Y   SRQ LTCTAYG+P P +I+W W P     
Sbjct: 417  NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475

Query: 468  MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
              A+       ++  +            +  N IES+      +EGKNK  S LV+ ++ 
Sbjct: 476  SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528

Query: 528  VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
            +S +Y C+ SNKVG   R I FY+T +P+GF   +E  P+E    G+ + LSC  + + Y
Sbjct: 529  ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE----GEDLKLSCTVNKFLY 584

Query: 586  EHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIPRVA 644
              + W  L        H                  + S +++A    H+ TL+L+I  V+
Sbjct: 585  RDVTWILLRTVNNRTMH-----------------YSISKQKMAITKEHSITLNLTIMNVS 627

Query: 645  PEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGA 704
             +  G Y C  ++  + ++   KK ++++  EAP L +NL+D  V +S S  + C   G 
Sbjct: 628  LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGV 687

Query: 705  HAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVA 764
              P I W+K+   ++++ G+ L   +  L I+RV EED G Y C   N KG V SSA + 
Sbjct: 688  PEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLT 747

Query: 765  VEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPL 824
            V+G+ DK ++E++ L  T V A  FW+LL L    M+R + ++IKT YLSIIMDP EVPL
Sbjct: 748  VQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSS-SEIKTDYLSIIMDPDEVPL 806

Query: 825  EEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEG 884
            +EQCE L YDAS+WEF RERL LG+ LG GAFGKVV+ASAFGI K  +C TVAVKMLKEG
Sbjct: 807  DEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG 866

Query: 885  ATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRD 944
            ATASE++ALM+ELKIL HIG+HLNVVNLLGACTK  GPLMVIVE+CKYGNLSN+L++KRD
Sbjct: 867  ATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD 926

Query: 945  AF---SPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEA 1001
             F      A     ++ +    +E  +  R    +S     +   + +        ++++
Sbjct: 927  LFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDS 986

Query: 1002 EDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARD 1061
            +  +  P+TMEDL+ YSFQVARGMEFL+SRKCIHRDLAARNILLSE++VVKICDFGLARD
Sbjct: 987  DGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD 1046

Query: 1062 IYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIN 1121
            IYK+PDYVRKG  RLPLKWMAPESIFDK+Y+T+SDVWS+GVLLWEIFSLG SPYPGVQ++
Sbjct: 1047 IYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMD 1106

Query: 1122 EEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE 1181
            E+FC RLR+G RMRAPE +TP I +IML+CW  DPK RP F+ELVE LGDLLQ    Q+ 
Sbjct: 1107 EDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDG 1166

Query: 1182 EEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLA 1241
            ++    P ++  +    F+  +         ++  +P      S   RY N   F     
Sbjct: 1167 KD--YIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKF----- 1219

Query: 1242 RGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLAS 1281
                     R+KTFEE  + P       D Q DS  +LAS
Sbjct: 1220 -----MSLERIKTFEE--LLPNATSMFDDYQGDSSTLLAS 1252


>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  361 bits (927), Expect = 2e-99
 Identities = 225/740 (30%), Positives = 370/740 (50%), Gaps = 65/740 (8%)

Query: 4   GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
           G  LC  L  CL LL G  SG  +  P L++    H++  G +L + CRG+   +W+   
Sbjct: 8   GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62

Query: 64  AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
               P    K+SE   + +   G + + +C  L L+   AN TG Y C Y  +    +  
Sbjct: 63  ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119

Query: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
           T ++ Y+F+ D  +PF+      P+ + +     + +PC V+ P + VTL+      L P
Sbjct: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179

Query: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
           DG+ ++WD R+G ++S     +   L CE T     + +N +L H   N + D+Q+   +
Sbjct: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238

Query: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
            ++LL G  LVLNCT     N+ V   W YP ++ +R      RR  Q+++  +   S+L
Sbjct: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296

Query: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
           TI  +   D G Y C+  +G      +T V +++  FI+V+  K  +LE  AG    +L 
Sbjct: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356

Query: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
           +K+ A+P PE  W KDG   + + + +     +L++K+VTE   G YT+ L    + + +
Sbjct: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416

Query: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
           N++  L+VNV PQI+EK  SS   P++Y   SRQ LTCTAYG+P P +I+W W P     
Sbjct: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475

Query: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
             A+       ++  +            +  N IES+      +EGKNK  S LV+ ++ 
Sbjct: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528

Query: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
           +S +Y C+ SNKVG   R I FY+T +P+GF   +E  P+    EG+ + LSC  + + Y
Sbjct: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLY 584

Query: 586 EHLRWYRL---NLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIP 641
             + W  L   N  T+H                     + S +++A    H+ TL+L+I 
Sbjct: 585 RDVTWILLRTVNNRTMH--------------------YSISKQKMAITKEHSITLNLTIM 624

Query: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLV 701
            V+ +  G Y C  ++  + ++   KK ++++  EAP L +NL+D  V +S S  + C  
Sbjct: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHA 684

Query: 702 AGAHAPSIVWYKDERLLEEK 721
            G   P I W+K+   ++++
Sbjct: 685 NGVPEPQITWFKNNHKIQQE 704



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)

Query: 638 LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 697
           L+I ++  + +G Y C V+   S        ++  +A    +  +      V    S  +
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355

Query: 698 QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRY--LCSVCNAKG 755
              V    +P +VW KD     EKS   L      L I+ V EEDAG Y  L S+  +  
Sbjct: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNV 414

Query: 756 CVNSSASVAV 765
             N +A++ V
Sbjct: 415 FKNLTATLIV 424


>gi|5453870 platelet-derived growth factor receptor alpha precursor
            [Homo sapiens]
          Length = 1089

 Score =  357 bits (916), Expect = 4e-98
 Identities = 241/726 (33%), Positives = 361/726 (49%), Gaps = 87/726 (11%)

Query: 516  KTVSKLVIQNANV--SAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEG-- 571
            K V  L +  A V  S  Y+C       + + +    ++    GF IE KP+   LE   
Sbjct: 270  KLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGF-IEIKPTFSQLEAVN 328

Query: 572  --QPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAP 629
              +      +  +Y    + W + NL+ + +                 T +   +E++  
Sbjct: 329  LHEVKHFVVEVRAYPPPRISWLKNNLTLIENL----------------TEITTDVEKIQE 372

Query: 630  GARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLV 689
                + L L   R   E  GHY    Q+     +   K Y      + P    +L D   
Sbjct: 373  IRYRSKLKLI--RAKEEDSGHYTIVAQN-----EDAVKSYTFELLTQVPSSILDLVDDHH 425

Query: 690  NVSDSLEMQCLVAGAHAPSIVWY--KDERLLEEKSGVDLADSNQKLSIQRVREEDA---- 743
              +    ++C   G   P I W   KD +    ++   +  +N    I  +   D     
Sbjct: 426  GSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVE 485

Query: 744  GRYL-----------CSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVL 792
            GR             C   N  G  N    +       + ++   +LV   ++ +    L
Sbjct: 486  GRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLV---LLVIVIISL 542

Query: 793  LLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLG 852
            ++L+    ++P + +I+   +  I   G   +      L YD S+WEFPR+ L LGRVLG
Sbjct: 543  IVLVVIWKQKPRY-EIRWRVIESISPDGHEYIYVDPMQLPYD-SRWEFPRDGLVLGRVLG 600

Query: 853  YGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNL 912
             GAFGKVVE +A+G+ +      VAVKMLK  A +SE +ALMSELKI+ H+G HLN+VNL
Sbjct: 601  SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660

Query: 913  LGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF-----------------SPCAEK--- 952
            LGACTK  GP+ +I E+C YG+L N+L   RD+F                 +P  E    
Sbjct: 661  LGACTK-SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRS 719

Query: 953  ----SPEQRGRFRAMVE------LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAE 1002
                S E  G +  M +      +  L+R+       +  + + +     +++  D E +
Sbjct: 720  YVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVK 779

Query: 1003 DLWLSP----LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGL 1058
            +L        LT+ DL+ +++QVARGMEFLAS+ C+HRDLAARN+LL++  +VKICDFGL
Sbjct: 780  NLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGL 839

Query: 1059 ARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGV 1118
            ARDI  D +YV KGS  LP+KWMAPESIFD +YTT SDVWS+G+LLWEIFSLG +PYPG+
Sbjct: 840  ARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGM 899

Query: 1119 QINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGL 1178
             ++  F  +++ G RM  P+ AT  +  IM+ CW+ +P+ RP+F  L EI+ +LL G+  
Sbjct: 900  MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYK 959

Query: 1179 QEEEEV 1184
            +  E++
Sbjct: 960  KSYEKI 965



 Score =  112 bits (279), Expect = 3e-24
 Identities = 113/449 (25%), Positives = 184/449 (40%), Gaps = 49/449 (10%)

Query: 30  PTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDA 89
           P++   E   V+    S S+ C G+  + W +P ++E         E + V    E  ++
Sbjct: 28  PSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEE---------ESSDVEIRNEENNS 78

Query: 90  RPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDT---L 146
             +  VL +    A  TG Y CYY + +           Y++V D +  F+    T   +
Sbjct: 79  GLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLV 138

Query: 147 LVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQC 206
           +V   D+  +PC  + P   VTL +   V+        +D R+G   +  +     Y+ C
Sbjct: 139 IVEDDDSAIIPCRTTDPETPVTLHNSEGVV-----PASYDSRQGFNGTFTV---GPYI-C 189

Query: 207 ETTWGDQDFLSNPFLVH-ITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFD 265
           E T   + F + PF V+ +      D+++   K++    GE +V+ C V+   N  V   
Sbjct: 190 EATVKGKKFQTIPFNVYALKATSELDLEMEALKTV-YKSGETIVVTCAVFN--NEVVDLQ 246

Query: 266 WDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEV 325
           W YPG+   +G  + E   +    +L   LT+   +  D G Y C A    +  +E  +V
Sbjct: 247 WTYPGEVKGKGITMLE-EIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305

Query: 326 I--VHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYK------------- 370
              VHE  FI ++      LEA    E+    V++ AYPPP   W K             
Sbjct: 306 TISVHEKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEIT 364

Query: 371 -DGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEA 429
            D + +        L L    E  +G YT+   N  A   ++ + EL+  VP  I +   
Sbjct: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDA--VKSYTFELLTQVPSSILDLVD 422

Query: 430 SSPSIYSRHSRQALTCTAYGVPLPLSIQW 458
                +     Q + CTA G PLP  I+W
Sbjct: 423 DH---HGSTGGQTVRCTAEGTPLP-DIEW 447



 Score = 35.8 bits (81), Expect = 0.29
 Identities = 32/132 (24%), Positives = 50/132 (37%), Gaps = 9/132 (6%)

Query: 624 LEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQN 683
           LEE+   +     +L++P    +  G Y C  +      K   K  +SV       +   
Sbjct: 261 LEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPT 320

Query: 684 LTDL-LVNVSDSLEMQCLVAGAHAPSIVWYKD-----ERLLEEKSGVDLADS---NQKLS 734
            + L  VN+ +       V     P I W K+     E L E  + V+         KL 
Sbjct: 321 FSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLK 380

Query: 735 IQRVREEDAGRY 746
           + R +EED+G Y
Sbjct: 381 LIRAKEEDSGHY 392


>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
            homolog isoform 2 precursor [Homo sapiens]
          Length = 972

 Score =  342 bits (878), Expect = 1e-93
 Identities = 198/506 (39%), Positives = 296/506 (58%), Gaps = 44/506 (8%)

Query: 697  MQCLVAGAHAPSIVWY----KDERLLEEKSGVDLADSNQ------KLSIQRVREEDA--- 743
            +QC+ AG   P+I WY     ++R       VD+   N       KL +Q   +  A   
Sbjct: 426  LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485

Query: 744  -GRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLI-FCNMR 801
             G   C   N  G  ++  + A +      ++   +L+G  ++A    ++++++ +  ++
Sbjct: 486  NGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQ 545

Query: 802  RPAH------ADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGA 855
            +P +       +   G   + +DP ++P + +          WEFPR RL  G+ LG GA
Sbjct: 546  KPMYEVQWKVVEEINGNNYVYIDPTQLPYDHK----------WEFPRNRLSFGKTLGAGA 595

Query: 856  FGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGA 915
            FGKVVEA+A+G+ K  +  TVAVKMLK  A  +E  ALMSELK+L ++GNH+N+VNLLGA
Sbjct: 596  FGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGA 655

Query: 916  CTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMV---ELARLDRR 972
            CT   GP +VI E+C YG+L NFLR KRD+F    ++   +   ++ ++   E +  D  
Sbjct: 656  CT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDST 714

Query: 973  RPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP---------LTMEDLVCYSFQVAR 1023
                  +   +    T+   RR+       +  ++P         L +EDL+ +S+QVA+
Sbjct: 715  NEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAK 774

Query: 1024 GMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAP 1083
            GM FLAS+ CIHRDLAARNILL+   + KICDFGLARDI  D +YV KG+ARLP+KWMAP
Sbjct: 775  GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAP 834

Query: 1084 ESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPA 1143
            ESIF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ ++ +F + +++G RM +PE A   
Sbjct: 835  ESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAE 894

Query: 1144 IRRIMLNCWSGDPKARPAFSELVEIL 1169
            +  IM  CW  DP  RP F ++V+++
Sbjct: 895  MYDIMKTCWDADPLKRPTFKQIVQLI 920



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 109/479 (22%), Positives = 186/479 (38%), Gaps = 67/479 (13%)

Query: 7   LCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQE 66
           L L L +  G     VS    +PP+++  +   ++  GD + + C     ++W +    E
Sbjct: 14  LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73

Query: 67  APATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAA 126
                +++ ++  +    E T+                 TG Y C  K+         + 
Sbjct: 74  T----NENKQNEWITEKAEATN-----------------TGKYTCTNKH-------GLSN 105

Query: 127 SSYVFVRDFEQPFINKPDTLLVNRKDA-MWVPCLVSIPGL-NVTLRSQSSVLWPDGQEVV 184
           S YVFVRD  + F+   D  L  ++D    V C ++ P + N +L+       P     +
Sbjct: 106 SIYVFVRDPAKLFL--VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFI 163

Query: 185 WDDRRGMLV-STPLLHDALYLQCETTWGDQDFLSNPFLVHIT-GNELYDIQLLPRKSLEL 242
            D + G+++ S    +  L L C      +  LS  F++ +    +   +  + + S  L
Sbjct: 164 PDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLL 223

Query: 243 LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQ 302
             GE+  + CT+  + +S V   W     Q +  +          + E  + LTI +   
Sbjct: 224 REGEEFTVTCTI-KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARV 282

Query: 303 HDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA---GDELVKLPVKLA 359
           +D G ++C ANN       +T + V +  FI++     P++  T      E V L V+  
Sbjct: 283 NDSGVFMCYANNTFGSANVTTTLEVVDKGFINI----FPMINTTVFVNDGENVDLIVEYE 338

Query: 360 AYPPPEF-QW-------------YKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSA 405
           A+P PE  QW             Y   +  S       L L  +     GTYT  + NS 
Sbjct: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNS- 397

Query: 406 AGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWT 464
             +   I+  + VN  P+I          Y R     L C A G P P +I W++ P T
Sbjct: 398 -DVNAAIAFNVYVNTKPEI--------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGT 446


>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
            homolog isoform 1 precursor [Homo sapiens]
          Length = 976

 Score =  342 bits (877), Expect = 1e-93
 Identities = 199/510 (39%), Positives = 299/510 (58%), Gaps = 48/510 (9%)

Query: 697  MQCLVAGAHAPSIVWY----KDERLLEEKSGVDLADSNQ------KLSIQRVREEDA--- 743
            +QC+ AG   P+I WY     ++R       VD+   N       KL +Q   +  A   
Sbjct: 426  LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485

Query: 744  -GRYLCSVCNAKGCVNSSASVAVEGSEDKG----SMEIVILVGTGVIAVFFWVLLLLI-F 797
             G   C   N  G  ++  + A +G+  +     ++   +L+G  ++A    ++++++ +
Sbjct: 486  NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545

Query: 798  CNMRRPAH------ADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVL 851
              +++P +       +   G   + +DP ++P + +          WEFPR RL  G+ L
Sbjct: 546  KYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHK----------WEFPRNRLSFGKTL 595

Query: 852  GYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVN 911
            G GAFGKVVEA+A+G+ K  +  TVAVKMLK  A  +E  ALMSELK+L ++GNH+N+VN
Sbjct: 596  GAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVN 655

Query: 912  LLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMV---ELAR 968
            LLGACT   GP +VI E+C YG+L NFLR KRD+F    ++   +   ++ ++   E + 
Sbjct: 656  LLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSC 714

Query: 969  LDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP---------LTMEDLVCYSF 1019
             D        +   +    T+   RR+       +  ++P         L +EDL+ +S+
Sbjct: 715  SDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSY 774

Query: 1020 QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLK 1079
            QVA+GM FLAS+ CIHRDLAARNILL+   + KICDFGLARDI  D +YV KG+ARLP+K
Sbjct: 775  QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVK 834

Query: 1080 WMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPEL 1139
            WMAPESIF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ ++ +F + +++G RM +PE 
Sbjct: 835  WMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEH 894

Query: 1140 ATPAIRRIMLNCWSGDPKARPAFSELVEIL 1169
            A   +  IM  CW  DP  RP F ++V+++
Sbjct: 895  APAEMYDIMKTCWDADPLKRPTFKQIVQLI 924



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 109/479 (22%), Positives = 186/479 (38%), Gaps = 67/479 (13%)

Query: 7   LCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQE 66
           L L L +  G     VS    +PP+++  +   ++  GD + + C     ++W +    E
Sbjct: 14  LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73

Query: 67  APATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAA 126
                +++ ++  +    E T+                 TG Y C  K+         + 
Sbjct: 74  T----NENKQNEWITEKAEATN-----------------TGKYTCTNKH-------GLSN 105

Query: 127 SSYVFVRDFEQPFINKPDTLLVNRKDA-MWVPCLVSIPGL-NVTLRSQSSVLWPDGQEVV 184
           S YVFVRD  + F+   D  L  ++D    V C ++ P + N +L+       P     +
Sbjct: 106 SIYVFVRDPAKLFL--VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFI 163

Query: 185 WDDRRGMLV-STPLLHDALYLQCETTWGDQDFLSNPFLVHIT-GNELYDIQLLPRKSLEL 242
            D + G+++ S    +  L L C      +  LS  F++ +    +   +  + + S  L
Sbjct: 164 PDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLL 223

Query: 243 LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQ 302
             GE+  + CT+  + +S V   W     Q +  +          + E  + LTI +   
Sbjct: 224 REGEEFTVTCTI-KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARV 282

Query: 303 HDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA---GDELVKLPVKLA 359
           +D G ++C ANN       +T + V +  FI++     P++  T      E V L V+  
Sbjct: 283 NDSGVFMCYANNTFGSANVTTTLEVVDKGFINI----FPMINTTVFVNDGENVDLIVEYE 338

Query: 360 AYPPPEF-QW-------------YKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSA 405
           A+P PE  QW             Y   +  S       L L  +     GTYT  + NS 
Sbjct: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNS- 397

Query: 406 AGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWT 464
             +   I+  + VN  P+I          Y R     L C A G P P +I W++ P T
Sbjct: 398 -DVNAAIAFNVYVNTKPEI--------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGT 446


>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
            sapiens]
          Length = 972

 Score =  337 bits (865), Expect = 4e-92
 Identities = 244/712 (34%), Positives = 348/712 (48%), Gaps = 91/712 (12%)

Query: 532  YKCVVSNKVGQDERLIYFYVTTIPD-GFTIESKPSEELLEGQPVLLSCQADSYK-YEHLR 589
            Y CV SN  G+    ++F V        + E    +E+  G+ + L    ++Y   +   
Sbjct: 276  YSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFN 335

Query: 590  WYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEG 649
            W    L    D    P L +      +               RH T +LS+PR+ P   G
Sbjct: 336  W--TYLGPFSDHQPEPKLANATTKDTY---------------RH-TFTLSLPRLKPSEAG 377

Query: 650  HYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSI 709
             Y    ++         +  L        R    ++ +   ++ S  + C  +G   P++
Sbjct: 378  RYSFLARNPGGWRALTFELTL--------RYPPEVSVIWTFINGSGTLLCAASGYPQPNV 429

Query: 710  VWYKDERLLEEKSGVDLADSNQ-------------------KLSIQRVRE----EDAGRY 746
             W      L+     D  D  Q                   K+++Q +      E    Y
Sbjct: 430  TW------LQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTY 483

Query: 747  LCSVCNAKGCVNSSASVAVEGSE-----DKGSMEIVILVGTGVIAVFFWVLLLLIFCNMR 801
             C   N+ G   S A + +         D+     V++    ++A+   +LLLL++   +
Sbjct: 484  ECRAHNSVGS-GSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQ 542

Query: 802  RPAHA------DIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGA 855
            +P +       +   G     +DP ++P  E+          WEFPR  L  G+ LG GA
Sbjct: 543  KPKYQVRWKIIESYEGNSYTFIDPTQLPYNEK----------WEFPRNNLQFGKTLGAGA 592

Query: 856  FGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGA 915
            FGKVVEA+AFG+ K  +   VAVKMLK  A A E  ALMSELKI+ H+G H N+VNLLGA
Sbjct: 593  FGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGA 652

Query: 916  CTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF---SPCAEKSPEQRGRFRAMVELARLDRR 972
            CT   GP++VI E+C YG+L NFLR K +A    S    + PE    ++ +    +  RR
Sbjct: 653  CTHG-GPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR 711

Query: 973  RPGSS----DRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFL 1028
              G S    D  +  R   T      +  D + ED    PL + DL+ +S QVA+GM FL
Sbjct: 712  DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG--RPLELRDLLHFSSQVAQGMAFL 769

Query: 1029 ASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD 1088
            AS+ CIHRD+AARN+LL+   V KI DFGLARDI  D +Y+ KG+ARLP+KWMAPESIFD
Sbjct: 770  ASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD 829

Query: 1089 KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIM 1148
             VYT QSDVWS+G+LLWEIFSLG +PYPG+ +N +F + ++DG +M  P  A   I  IM
Sbjct: 830  CVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 889

Query: 1149 LNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS 1200
              CW+ +P  RP F ++   L +  Q +  + E +    P SS+S   GS S
Sbjct: 890  QACWALEPTHRPTFQQICSFLQE--QAQEDRRERDYTNLPSSSRSGGSGSSS 939



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 125/614 (20%), Positives = 222/614 (36%), Gaps = 114/614 (18%)

Query: 30  PTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDA 89
           P +  +    V+  G ++++ C G   +EW  P +       D  S              
Sbjct: 21  PVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSS------------- 67

Query: 90  RPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPF-INKPDTLLV 148
                +L  +     +TG+Y C     +       +A+ +++V+D  +P+ +   + ++ 
Sbjct: 68  -----ILSTNNATFQNTGTYRC----TEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVF 118

Query: 149 NRKDAMWVPCLVSIPGLN-----VTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALY 203
             +DA+ +PCL++ P L      V +R +  +   +     W    G  +       +  
Sbjct: 119 EDQDAL-LPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPW---HGFTIHRAKFIQSQD 174

Query: 204 LQCETTWGDQDFLSNPFLVH----ITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFN 259
            QC    G +  +S    +     I G     + L+P + + +  GE   + C+      
Sbjct: 175 YQCSALMGGRKVMSISIRLKVQKVIPGPPA--LTLVPAELVRIR-GEAAQIVCSA----- 226

Query: 260 SGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDL---GSYVCKANNGI 316
           S V  ++D    Q    K    ++S   +     +LT+ N+ Q D    G+Y C A+N  
Sbjct: 227 SSVDVNFDV-FLQHNNTKLAIPQQSDFHNNRYQKVLTL-NLDQVDFQHAGNYSCVASNVQ 284

Query: 317 QRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPE-FQWYKDGKAL 375
            +   S    V E+ ++++   +  I E T G+ L  L V + AYP  + F W   G   
Sbjct: 285 GKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGL-NLKVMVEAYPGLQGFNWTYLGP-- 341

Query: 376 SGRHSPHALVLKEVT-EASTGTYTLALWN---SAAG----LRRN------ISLELVVNVP 421
              H P   +    T +    T+TL+L     S AG    L RN      ++ EL +  P
Sbjct: 342 FSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYP 401

Query: 422 PQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQD 481
           P++      S      +    L C A G P P         W  C     R         
Sbjct: 402 PEV------SVIWTFINGSGTLLCAASGYPQPNV------TWLQCSGHTDR--------- 440

Query: 482 LMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVG 541
               C + + +   D   P    +  ++    K    S L ++    +  Y+C   N VG
Sbjct: 441 ----CDEAQVLQVWDDPYP----EVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVG 492

Query: 542 QDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADS-----------YKYEHLRW 590
                       IP      + P +E L   PV+++C +             YKY+    
Sbjct: 493 SGSWAF------IPISAGAHTHPPDEFL-FTPVVVACMSIMALLLLLLLLLLYKYKQKPK 545

Query: 591 YRLNLSTLHDAHGN 604
           Y++    +    GN
Sbjct: 546 YQVRWKIIESYEGN 559


>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
           [Homo sapiens]
          Length = 687

 Score =  329 bits (844), Expect = 1e-89
 Identities = 209/692 (30%), Positives = 344/692 (49%), Gaps = 65/692 (9%)

Query: 4   GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
           G  LC  L  CL LL G  SG  +  P L++    H++  G +L + CRG+   +W+   
Sbjct: 8   GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62

Query: 64  AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
               P    K+SE   + +   G + + +C  L L+   AN TG Y C Y  +    +  
Sbjct: 63  ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119

Query: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
           T ++ Y+F+ D  +PF+      P+ + +     + +PC V+ P + VTL+      L P
Sbjct: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179

Query: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
           DG+ ++WD R+G ++S     +   L CE T     + +N +L H   N + D+Q+   +
Sbjct: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238

Query: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
            ++LL G  LVLNCT     N+ V   W YP ++ +R      RR  Q+++  +   S+L
Sbjct: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296

Query: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
           TI  +   D G Y C+  +G      +T V +++  FI+V+  K  +LE  AG    +L 
Sbjct: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356

Query: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
           +K+ A+P PE  W KDG   + + + +     +L++K+VTE   G YT+ L    + + +
Sbjct: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416

Query: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
           N++  L+VNV PQI+EK  SS   P++Y   SRQ LTCTAYG+P P +I+W W P     
Sbjct: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475

Query: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
             A+       ++  +            +  N IES+      +EGKNK  S LV+ ++ 
Sbjct: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528

Query: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
           +S +Y C+ SNKVG   R I FY+T +P+GF   +E  P+    EG+ + LSC  + + Y
Sbjct: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLY 584

Query: 586 EHLRWYRL---NLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIP 641
             + W  L   N  T+H                     + S +++A    H+ TL+L+I 
Sbjct: 585 RDVTWILLRTVNNRTMH--------------------YSISKQKMAITKEHSITLNLTIM 624

Query: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQ 673
            V+ +  G Y C  ++  + ++   KK ++++
Sbjct: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIR 656



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)

Query: 638 LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 697
           L+I ++  + +G Y C V+   S        ++  +A    +  +      V    S  +
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355

Query: 698 QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRY--LCSVCNAKG 755
              V    +P +VW KD     EKS   L      L I+ V EEDAG Y  L S+  +  
Sbjct: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNV 414

Query: 756 CVNSSASVAV 765
             N +A++ V
Sbjct: 415 FKNLTATLIV 424


>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
          Length = 993

 Score =  326 bits (836), Expect = 8e-89
 Identities = 191/450 (42%), Positives = 265/450 (58%), Gaps = 20/450 (4%)

Query: 783  GVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPR 842
            GV  +F  VL LLI    ++    + +   + +                 YD  +WEFPR
Sbjct: 549  GVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDL-KWEFPR 607

Query: 843  ERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIH 902
            E L  G+VLG GAFGKV+ A+A+GI K      VAVKMLKE A +SE  ALMSELK++  
Sbjct: 608  ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 667

Query: 903  IGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF-SPCAEKSPEQRGRFR 961
            +G+H N+VNLLGACT   GP+ +I E+C YG+L N+LR+KR+ F     E   E    F 
Sbjct: 668  LGSHENIVNLLGACTL-SGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFY 726

Query: 962  AMVELARLDRRRPGS--------SDRV--LFARFSKTEGGARRASPDQEAEDLWLSPLTM 1011
               + +  +   PGS        SD++  L      +E      +  +  E+  L+ LT 
Sbjct: 727  PTFQ-SHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTF 785

Query: 1012 EDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRK 1071
            EDL+C+++QVA+GMEFL  + C+HRDLAARN+L++   VVKICDFGLARDI  D +YV +
Sbjct: 786  EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 845

Query: 1072 GSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDG 1131
            G+ARLP+KWMAPES+F+ +YT +SDVWS+G+LLWEIFSLG +PYPG+ ++  F + +++G
Sbjct: 846  GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNG 905

Query: 1132 TRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG----DLLQGRGLQEEEEVCMA 1187
             +M  P  AT  I  IM +CW+ D + RP+F  L   LG    D  +      +  V   
Sbjct: 906  FKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSEC 965

Query: 1188 PRSSQSSEEGSFSQVSTMALHIAQADAEDS 1217
            P + Q+     FS+   + L   QA  EDS
Sbjct: 966  PHTYQNRR--PFSREMDLGLLSPQAQVEDS 993


>gi|4505683 platelet-derived growth factor receptor beta precursor
            [Homo sapiens]
          Length = 1106

 Score =  315 bits (807), Expect = 2e-85
 Identities = 234/715 (32%), Positives = 353/715 (49%), Gaps = 93/715 (13%)

Query: 529  SAMYKCVVSNKVG--QDERLIYFYVTTIPDGFT-----IESKPSEELLEGQPVLLSCQAD 581
            S  Y C V+  V   QDE+ I   +T +  G+      + +    EL   + + +  +A 
Sbjct: 286  SGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEA- 342

Query: 582  SYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIP 641
             Y    + W++ N  TL D+    + L  +NV                  R+ +  L++ 
Sbjct: 343  -YPPPTVLWFKDN-RTLGDSSAGEIALSTRNVS---------------ETRYVS-ELTLV 384

Query: 642  RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLV 701
            RV     GHY        +  +   +  ++V  +    L+++  D     S    ++C  
Sbjct: 385  RVKVAEAGHYTMRAFHEDAEVQLSFQLQINVP-VRVLELSESHPD-----SGEQTVRCRG 438

Query: 702  AGAHAPSIVWY--KD-ERLLEEKSGVDLADSNQKLS-----------------IQRVREE 741
             G   P+I+W   +D +R   E     L +S+++ S                 +  +R +
Sbjct: 439  RGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQ 498

Query: 742  DAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMR 801
               R L   C  +  V       +          +VI     ++ +    L++LI    +
Sbjct: 499  HVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQK 558

Query: 802  RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
            +P + +I+   +  +   G   +      L YD S WE PR++L LGR LG GAFG+VVE
Sbjct: 559  KPRY-EIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLGSGAFGQVVE 616

Query: 862  ASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQG 921
            A+A G+    +   VAVKMLK  A +SE +ALMSELKI+ H+G HLNVVNLLGACTK  G
Sbjct: 617  ATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKG-G 675

Query: 922  PLMVIVEFCKYGNLSNFLRAKRDAF---------SPCAEK-----------------SPE 955
            P+ +I E+C+YG+L ++L   +  F          P AE                  + E
Sbjct: 676  PIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGE 735

Query: 956  QRGRFRAMVE------LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP- 1008
              G +  M +      +  LD +       +  + +         ++P++      ++  
Sbjct: 736  SDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES 795

Query: 1009 --LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDP 1066
              L+  DLV +S+QVA GMEFLAS+ C+HRDLAARN+L+ E  +VKICDFGLARDI +D 
Sbjct: 796  PVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDS 855

Query: 1067 DYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQ 1126
            +Y+ KGS  LPLKWMAPESIF+ +YTT SDVWSFG+LLWEIF+LG +PYP + +NE+F  
Sbjct: 856  NYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYN 915

Query: 1127 RLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE 1181
             ++ G RM  P  A+  I  IM  CW    + RP FS+LV +L  LL G G +++
Sbjct: 916  AIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL-GEGYKKK 969



 Score =  111 bits (277), Expect = 5e-24
 Identities = 140/574 (24%), Positives = 240/574 (41%), Gaps = 78/574 (13%)

Query: 3   RGAALCLRLWLCLGLLDGLVS-GYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAW 61
           +G  L L L L   LL+  +S G  +TPP   +     V++   +  ++C G  P+ W  
Sbjct: 13  KGELLLLSLLL---LLEPQISQGLVVTPPGPEL-----VLNVSSTFVLTCSGSAPVVWER 64

Query: 62  PGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIE 121
             +QE P    K  + T             +  VL L  +   DTG Y C +   +  +E
Sbjct: 65  M-SQEPPQEMAKAQDGT-------------FSSVLTLTNLTGLDTGEYFCTHNDSRG-LE 109

Query: 122 GTTAASSYVFVRDFEQPFI-NKPDTLLVNRKDA--MWVPCLVSIPGLNVTLRSQSSVLWP 178
                  Y+FV D    F+ N  + L +   +   + +PC V+ P L VTL  +   +  
Sbjct: 110 TDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDV-- 167

Query: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
               V +D +RG    + +  D  Y+ C+TT GD++  S+ + V+       ++ +   +
Sbjct: 168 -ALPVPYDHQRGF---SGIFEDRSYI-CKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQ 222

Query: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIH 298
           ++ +  GE + L C V    N  V F+W YP K++ R               + SIL I 
Sbjct: 223 TV-VRQGENITLMCIVIG--NEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIP 279

Query: 299 NVSQHDLGSYVCKANNGIQRFRE--STEVIVHENPFISVEWLKGPILEATAGDELVKLPV 356
           +    D G+Y C     +   ++  +  + V E+ ++ +    G +  A        L V
Sbjct: 280 SAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRT-LQV 338

Query: 357 KLAAYPPPEFQWYKDGK----------ALSGRHSPHA-----LVLKEVTEASTGTYTLAL 401
              AYPPP   W+KD +          ALS R+         L L  V  A  G YT+  
Sbjct: 339 VFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRA 398

Query: 402 WNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWR 461
           ++  A ++  +S +L +NVP ++ E   S P        Q + C   G+P P  I     
Sbjct: 399 FHEDAEVQ--LSFQLQINVPVRVLELSESHPD----SGEQTVRCRGRGMPQPNII----- 447

Query: 462 PWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKL 521
            W+ C+        +R  ++L P         + +  + +E+  T+ E  E + + VS L
Sbjct: 448 -WSACRDL------KRCPRELPPTLLG----NSSEEESQLETNVTYWE-EEQEFEVVSTL 495

Query: 522 VIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIP 555
            +Q+ +     +C + N VGQD + +     ++P
Sbjct: 496 RLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLP 529


>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
            [Homo sapiens]
          Length = 808

 Score =  303 bits (775), Expect = 1e-81
 Identities = 210/604 (34%), Positives = 291/604 (48%), Gaps = 118/604 (19%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            RH   SL +  V P   G+Y C V+++    +  +   +  ++   P L   L  +    
Sbjct: 207  RHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAV 266

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD--------------LADSNQKLSIQ 736
            +   +E  C V     P I W K   +   K G D                +++ +L + 
Sbjct: 267  LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLA 326

Query: 737  RVREEDAGRYLCSVCNAKGCVNSSASVAVEG----------SEDKGSMEIVIL-VGTGVI 785
             V E D G YLC   N  G    +  ++V G          +++ GS+   IL  G G  
Sbjct: 327  NVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFF 386

Query: 786  AVFFWVLLLLIFCNMRRPAHADIKTGYLSII----------------------------M 817
             +F  V+  +  C +R P    + +  +  I                            +
Sbjct: 387  -LFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARL 445

Query: 818  DPGEVPLEEQCEYLSYDAS-QWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCD-- 874
              GE P       L   A  +WE  R RL LG+ LG G FG+VV A A GI K  +    
Sbjct: 446  SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 505

Query: 875  TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGN 934
            TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL V+VE+   GN
Sbjct: 506  TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQG-GPLYVLVEYAAKGN 564

Query: 935  LSNFLRAKRD-----AFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTE 989
            L  FLRA+R      +F  C  K PE++                                
Sbjct: 565  LREFLRARRPPGLDYSFDTC--KPPEEQ-------------------------------- 590

Query: 990  GGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESD 1049
                               LT +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +
Sbjct: 591  -------------------LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 631

Query: 1050 VVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS 1109
            V+KI DFGLARD++    Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVLLWEIF+
Sbjct: 632  VMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 691

Query: 1110 LGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL 1169
            LG SPYPG+ + EE  + L++G RM  P   T  +  IM  CW   P  RP F +LVE L
Sbjct: 692  LGGSPYPGIPV-EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750

Query: 1170 GDLL 1173
              +L
Sbjct: 751  DRVL 754



 Score = 38.5 bits (88), Expect = 0.044
 Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A      V+     A  P P   W K+G+   G         RH   +LV++ V  + 
Sbjct: 163 LLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSD 222

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +R+  +L+++   P
Sbjct: 223 RGNYTCVVENKFGSIRQTYTLDVLERSP 250



 Score = 37.4 bits (85), Expect = 0.099
 Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 3/82 (3%)

Query: 687 LLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDA 743
           L V  ++++  +C  AG   PSI W K+ R    +    G+ L      L ++ V   D 
Sbjct: 164 LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223

Query: 744 GRYLCSVCNAKGCVNSSASVAV 765
           G Y C V N  G +  + ++ V
Sbjct: 224 GNYTCVVENKFGSIRQTYTLDV 245


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  302 bits (774), Expect = 1e-81
 Identities = 215/602 (35%), Positives = 294/602 (48%), Gaps = 116/602 (19%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            RH   SL +  V P   G+Y C V+++    +  +   +  ++   P L   L  +    
Sbjct: 207  RHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAV 266

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD---------LADSN------QKLSI 735
            +   +E  C V     P I W K   +   K G D          A +N      + LS+
Sbjct: 267  LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSL 326

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDK-------GSMEIVIL-VGTGVIAV 787
              V  EDAG Y C   N+ G  + SA + V  +E++       GS+   IL  G G   +
Sbjct: 327  HNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFF-L 385

Query: 788  FFWVLLLLIFCNMRRPAHADIKTGYLSII----------------------------MDP 819
            F  V+  +  C +R P    + +  +  I                            +  
Sbjct: 386  FILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSS 445

Query: 820  GEVPLEEQCEYLSYDAS-QWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCD--TV 876
            GE P       L   A  +WE  R RL LG+ LG G FG+VV A A GI K  +    TV
Sbjct: 446  GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 505

Query: 877  AVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLS 936
            AVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL V+VE+   GNL 
Sbjct: 506  AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQG-GPLYVLVEYAAKGNLR 564

Query: 937  NFLRAKRD-----AFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGG 991
             FLRA+R      +F  C  K PE++                                  
Sbjct: 565  EFLRARRPPGLDYSFDTC--KPPEEQ---------------------------------- 588

Query: 992  ARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVV 1051
                             LT +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +V+
Sbjct: 589  -----------------LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 631

Query: 1052 KICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLG 1111
            KI DFGLARD++    Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVLLWEIF+LG
Sbjct: 632  KIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLG 691

Query: 1112 ASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGD 1171
             SPYPG+ + EE  + L++G RM  P   T  +  IM  CW   P  RP F +LVE L  
Sbjct: 692  GSPYPGIPV-EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR 750

Query: 1172 LL 1173
            +L
Sbjct: 751  VL 752



 Score = 38.5 bits (88), Expect = 0.044
 Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A      V+     A  P P   W K+G+   G         RH   +LV++ V  + 
Sbjct: 163 LLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSD 222

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +R+  +L+++   P
Sbjct: 223 RGNYTCVVENKFGSIRQTYTLDVLERSP 250



 Score = 37.4 bits (85), Expect = 0.099
 Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 3/82 (3%)

Query: 687 LLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDA 743
           L V  ++++  +C  AG   PSI W K+ R    +    G+ L      L ++ V   D 
Sbjct: 164 LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223

Query: 744 GRYLCSVCNAKGCVNSSASVAV 765
           G Y C V N  G +  + ++ V
Sbjct: 224 GNYTCVVENKFGSIRQTYTLDV 245


>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
            [Homo sapiens]
          Length = 680

 Score =  300 bits (767), Expect = 8e-81
 Identities = 207/603 (34%), Positives = 291/603 (48%), Gaps = 111/603 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 121  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD------------LADSNQK-LSIQR 737
            V   +E  C V     P I W K       K G D            +  SN + L++  
Sbjct: 181  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFN 240

Query: 738  VREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFW------- 790
            V E DAG Y+C V N  G  N SA + V   +     E  I      + +  +       
Sbjct: 241  VTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLI 300

Query: 791  --VLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC-------------------- 828
              +++ +I C M+        +   ++      +PL  Q                     
Sbjct: 301  ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 360

Query: 829  ----------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSS 872
                            EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K   
Sbjct: 361  TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 420

Query: 873  CD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFC 930
             +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+ 
Sbjct: 421  KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYA 479

Query: 931  KYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEG 990
              GNL  +LRA                             RR PG        R      
Sbjct: 480  SKGNLREYLRA-----------------------------RRPPGMEYSYDINRV----- 505

Query: 991  GARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDV 1050
                  P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E++V
Sbjct: 506  ------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 551

Query: 1051 VKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSL 1110
            +KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF+L
Sbjct: 552  MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 611

Query: 1111 GASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG 1170
            G SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L 
Sbjct: 612  GGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 670

Query: 1171 DLL 1173
             +L
Sbjct: 671  RIL 673



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 77  LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 136

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 137 KGNYTCVVENEYGSINHTYHLDVVERSP 164



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 80  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 139

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 140 YTCVVENEYGSIN 152


>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
            [Homo sapiens]
          Length = 769

 Score =  300 bits (767), Expect = 8e-81
 Identities = 207/603 (34%), Positives = 291/603 (48%), Gaps = 111/603 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 210  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD------------LADSNQK-LSIQR 737
            V   +E  C V     P I W K       K G D            +  SN + L++  
Sbjct: 270  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFN 329

Query: 738  VREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFW------- 790
            V E DAG Y+C V N  G  N SA + V   +     E  I      + +  +       
Sbjct: 330  VTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLI 389

Query: 791  --VLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC-------------------- 828
              +++ +I C M+        +   ++      +PL  Q                     
Sbjct: 390  ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449

Query: 829  ----------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSS 872
                            EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K   
Sbjct: 450  TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 509

Query: 873  CD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFC 930
             +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+ 
Sbjct: 510  KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYA 568

Query: 931  KYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEG 990
              GNL  +LRA                             RR PG        R      
Sbjct: 569  SKGNLREYLRA-----------------------------RRPPGMEYSYDINRV----- 594

Query: 991  GARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDV 1050
                  P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E++V
Sbjct: 595  ------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 640

Query: 1051 VKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSL 1110
            +KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF+L
Sbjct: 641  MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 700

Query: 1111 GASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG 1170
            G SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L 
Sbjct: 701  GGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 759

Query: 1171 DLL 1173
             +L
Sbjct: 760  RIL 762



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSP 253



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 228

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 229 YTCVVENEYGSIN 241


>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
            [Homo sapiens]
          Length = 822

 Score =  300 bits (767), Expect = 8e-81
 Identities = 207/603 (34%), Positives = 291/603 (48%), Gaps = 111/603 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 210  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD------------LADSNQK-LSIQR 737
            V   +E  C V     P I W K       K G D            +  SN + L++  
Sbjct: 270  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFN 329

Query: 738  VREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFW------- 790
            V E DAG Y+C V N  G  N SA + V   +     E  I      + +  +       
Sbjct: 330  VTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLI 389

Query: 791  --VLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC-------------------- 828
              +++ +I C M+        +   ++      +PL  Q                     
Sbjct: 390  ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449

Query: 829  ----------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSS 872
                            EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K   
Sbjct: 450  TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 509

Query: 873  CD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFC 930
             +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+ 
Sbjct: 510  KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYA 568

Query: 931  KYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEG 990
              GNL  +LRA                             RR PG        R      
Sbjct: 569  SKGNLREYLRA-----------------------------RRPPGMEYSYDINRV----- 594

Query: 991  GARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDV 1050
                  P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E++V
Sbjct: 595  ------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 640

Query: 1051 VKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSL 1110
            +KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF+L
Sbjct: 641  MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 700

Query: 1111 GASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG 1170
            G SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L 
Sbjct: 701  GGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 759

Query: 1171 DLL 1173
             +L
Sbjct: 760  RIL 762



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSP 253



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 228

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 229 YTCVVENEYGSIN 241


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
            [Homo sapiens]
          Length = 731

 Score =  299 bits (765), Expect = 1e-80
 Identities = 217/652 (33%), Positives = 317/652 (48%), Gaps = 109/652 (16%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+AT S+ +  V P  +G+Y C V++      H ++  +  ++   P L   L  +  V 
Sbjct: 118  RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVA 177

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSNQK-LSI 735
            +  ++E  C V     P I W K   +   K              +GV+  D   + L +
Sbjct: 178  LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 237

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEI------VILVGTGVIAVF 788
            + V  EDAG Y C   N+ G  + SA + V E  E++ ++        +I+  TG   + 
Sbjct: 238  RNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS 297

Query: 789  FWVLLLLIF-----------------------------CNMRRPAHADIKTGYLSI---- 815
              V  ++++                               +   + A + +G L +    
Sbjct: 298  CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 357

Query: 816  IMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG--SSC 873
            +   G   L    EY   +  +WE PR+RL LG+ LG G FG+VV A A G+ K   +  
Sbjct: 358  LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 417

Query: 874  DTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG 933
              VAVKMLK  AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+   G
Sbjct: 418  TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKG 476

Query: 934  NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGAR 993
            NL  +L+A                             RR PG                  
Sbjct: 477  NLREYLQA-----------------------------RRPPGLEYCY------------- 494

Query: 994  RASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKI 1053
              +P    E+     L+ +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI
Sbjct: 495  --NPSHNPEE----QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 548

Query: 1054 CDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 1113
             DFGLARDI+    Y +  + RLP+KWMAPE++FD++YT QSDVWSFGVLLWEIF+LG S
Sbjct: 549  ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 608

Query: 1114 PYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            PYPGV + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L  ++
Sbjct: 609  PYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 667

Query: 1174 QGRGLQEEEEVCM-APRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRH 1224
                 QE  ++ M   + S S  +   S  S+    +   +     P L RH
Sbjct: 668  ALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH 719



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 11/126 (8%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A    + VK     +  P P  +W K+GK             R++  ++++  V  + 
Sbjct: 74  LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 133

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVPPQ-IHEKEASSPSIYSRHSRQALTCTAYGVPL 452
            G YT  + N    +     L++V   P + I +    +    +  S     C  Y  P 
Sbjct: 134 KGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 193

Query: 453 PLSIQW 458
           P  IQW
Sbjct: 194 P-HIQW 198


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
            [Homo sapiens]
          Length = 733

 Score =  299 bits (765), Expect = 1e-80
 Identities = 217/652 (33%), Positives = 317/652 (48%), Gaps = 109/652 (16%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+AT S+ +  V P  +G+Y C V++      H ++  +  ++   P L   L  +  V 
Sbjct: 120  RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVA 179

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSNQK-LSI 735
            +  ++E  C V     P I W K   +   K              +GV+  D   + L +
Sbjct: 180  LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 239

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEI------VILVGTGVIAVF 788
            + V  EDAG Y C   N+ G  + SA + V E  E++ ++        +I+  TG   + 
Sbjct: 240  RNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS 299

Query: 789  FWVLLLLIF-----------------------------CNMRRPAHADIKTGYLSI---- 815
              V  ++++                               +   + A + +G L +    
Sbjct: 300  CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 359

Query: 816  IMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG--SSC 873
            +   G   L    EY   +  +WE PR+RL LG+ LG G FG+VV A A G+ K   +  
Sbjct: 360  LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 419

Query: 874  DTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG 933
              VAVKMLK  AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+   G
Sbjct: 420  TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKG 478

Query: 934  NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGAR 993
            NL  +L+A                             RR PG                  
Sbjct: 479  NLREYLQA-----------------------------RRPPGLEYCY------------- 496

Query: 994  RASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKI 1053
              +P    E+     L+ +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI
Sbjct: 497  --NPSHNPEE----QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 550

Query: 1054 CDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 1113
             DFGLARDI+    Y +  + RLP+KWMAPE++FD++YT QSDVWSFGVLLWEIF+LG S
Sbjct: 551  ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 610

Query: 1114 PYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            PYPGV + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L  ++
Sbjct: 611  PYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 669

Query: 1174 QGRGLQEEEEVCM-APRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRH 1224
                 QE  ++ M   + S S  +   S  S+    +   +     P L RH
Sbjct: 670  ALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH 721



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 11/126 (8%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A    + VK     +  P P  +W K+GK             R++  ++++  V  + 
Sbjct: 76  LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 135

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVPPQ-IHEKEASSPSIYSRHSRQALTCTAYGVPL 452
            G YT  + N    +     L++V   P + I +    +    +  S     C  Y  P 
Sbjct: 136 KGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 195

Query: 453 PLSIQW 458
           P  IQW
Sbjct: 196 P-HIQW 200


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
            [Homo sapiens]
          Length = 820

 Score =  299 bits (765), Expect = 1e-80
 Identities = 217/652 (33%), Positives = 317/652 (48%), Gaps = 109/652 (16%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+AT S+ +  V P  +G+Y C V++      H ++  +  ++   P L   L  +  V 
Sbjct: 207  RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVA 266

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSNQK-LSI 735
            +  ++E  C V     P I W K   +   K              +GV+  D   + L +
Sbjct: 267  LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 326

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEI------VILVGTGVIAVF 788
            + V  EDAG Y C   N+ G  + SA + V E  E++ ++        +I+  TG   + 
Sbjct: 327  RNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS 386

Query: 789  FWVLLLLIF-----------------------------CNMRRPAHADIKTGYLSI---- 815
              V  ++++                               +   + A + +G L +    
Sbjct: 387  CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 446

Query: 816  IMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG--SSC 873
            +   G   L    EY   +  +WE PR+RL LG+ LG G FG+VV A A G+ K   +  
Sbjct: 447  LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 506

Query: 874  DTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG 933
              VAVKMLK  AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+   G
Sbjct: 507  TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKG 565

Query: 934  NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGAR 993
            NL  +L+A                             RR PG                  
Sbjct: 566  NLREYLQA-----------------------------RRPPGLEYCY------------- 583

Query: 994  RASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKI 1053
              +P    E+     L+ +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI
Sbjct: 584  --NPSHNPEE----QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 637

Query: 1054 CDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 1113
             DFGLARDI+    Y +  + RLP+KWMAPE++FD++YT QSDVWSFGVLLWEIF+LG S
Sbjct: 638  ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 697

Query: 1114 PYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            PYPGV + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L  ++
Sbjct: 698  PYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 756

Query: 1174 QGRGLQEEEEVCM-APRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRH 1224
                 QE  ++ M   + S S  +   S  S+    +   +     P L RH
Sbjct: 757  ALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH 808



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 11/126 (8%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A    + VK     +  P P  +W K+GK             R++  ++++  V  + 
Sbjct: 163 LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 222

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVPPQ-IHEKEASSPSIYSRHSRQALTCTAYGVPL 452
            G YT  + N    +     L++V   P + I +    +    +  S     C  Y  P 
Sbjct: 223 KGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 282

Query: 453 PLSIQW 458
           P  IQW
Sbjct: 283 P-HIQW 287


>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
            [Homo sapiens]
          Length = 822

 Score =  299 bits (765), Expect = 1e-80
 Identities = 217/652 (33%), Positives = 317/652 (48%), Gaps = 109/652 (16%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+AT S+ +  V P  +G+Y C V++      H ++  +  ++   P L   L  +  V 
Sbjct: 209  RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVA 268

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSNQK-LSI 735
            +  ++E  C V     P I W K   +   K              +GV+  D   + L +
Sbjct: 269  LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 328

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEI------VILVGTGVIAVF 788
            + V  EDAG Y C   N+ G  + SA + V E  E++ ++        +I+  TG   + 
Sbjct: 329  RNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS 388

Query: 789  FWVLLLLIF-----------------------------CNMRRPAHADIKTGYLSI---- 815
              V  ++++                               +   + A + +G L +    
Sbjct: 389  CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 448

Query: 816  IMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG--SSC 873
            +   G   L    EY   +  +WE PR+RL LG+ LG G FG+VV A A G+ K   +  
Sbjct: 449  LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 508

Query: 874  DTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG 933
              VAVKMLK  AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+   G
Sbjct: 509  TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKG 567

Query: 934  NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGAR 993
            NL  +L+A                             RR PG                  
Sbjct: 568  NLREYLQA-----------------------------RRPPGLEYCY------------- 585

Query: 994  RASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKI 1053
              +P    E+     L+ +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI
Sbjct: 586  --NPSHNPEE----QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639

Query: 1054 CDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 1113
             DFGLARDI+    Y +  + RLP+KWMAPE++FD++YT QSDVWSFGVLLWEIF+LG S
Sbjct: 640  ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699

Query: 1114 PYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            PYPGV + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L  ++
Sbjct: 700  PYPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758

Query: 1174 QGRGLQEEEEVCM-APRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRH 1224
                 QE  ++ M   + S S  +   S  S+    +   +     P L RH
Sbjct: 759  ALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH 810



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 11/126 (8%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A    + VK     +  P P  +W K+GK             R++  ++++  V  + 
Sbjct: 165 LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 224

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVPPQ-IHEKEASSPSIYSRHSRQALTCTAYGVPL 452
            G YT  + N    +     L++V   P + I +    +    +  S     C  Y  P 
Sbjct: 225 KGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284

Query: 453 PLSIQW 458
           P  IQW
Sbjct: 285 P-HIQW 289


>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
            [Homo sapiens]
          Length = 707

 Score =  296 bits (757), Expect = 1e-79
 Identities = 213/616 (34%), Positives = 300/616 (48%), Gaps = 116/616 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 121  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSN-QKLSI 735
            V   +E  C V     P I W K       K              +GV+  D   + L I
Sbjct: 181  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV--------EGSEDKGSMEIVIL-VGTGVIA 786
            + V  EDAG Y C   N+ G    SA + V        E +     +EI I  +G  +IA
Sbjct: 241  RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300

Query: 787  VFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC------------------ 828
                +++ +I C M+        +   ++      +PL  Q                   
Sbjct: 301  C---MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 357

Query: 829  ------------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG 870
                              EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K 
Sbjct: 358  ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 417

Query: 871  SSCD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVE 928
               +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE
Sbjct: 418  KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVE 476

Query: 929  FCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKT 988
            +   GNL  +LRA                             RR PG        R    
Sbjct: 477  YASKGNLREYLRA-----------------------------RRPPGMEYSYDINRV--- 504

Query: 989  EGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSES 1048
                    P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E+
Sbjct: 505  --------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 548

Query: 1049 DVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIF 1108
            +V+KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF
Sbjct: 549  NVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 608

Query: 1109 SLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEI 1168
            +LG SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE 
Sbjct: 609  TLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 667

Query: 1169 LGDLLQGRGLQEEEEV 1184
            L  +L     +EE++V
Sbjct: 668  LDRILTLTTNEEEKKV 683



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 77  LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 136

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 137 KGNYTCVVENEYGSINHTYHLDVVERSP 164



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 80  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 139

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 140 YTCVVENEYGSIN 152


>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
            [Homo sapiens]
          Length = 704

 Score =  294 bits (752), Expect = 4e-79
 Identities = 210/603 (34%), Positives = 294/603 (48%), Gaps = 114/603 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 95   RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSN-QKLSI 735
            V   +E  C V     P I W K       K              +GV+  D   + L I
Sbjct: 155  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV--------EGSEDKGSMEIVIL-VGTGVIA 786
            + V  EDAG Y C   N+ G    SA + V        E +     +EI I  +G  +IA
Sbjct: 215  RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274

Query: 787  VFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC------------------ 828
                +++ +I C M+        +   ++      +PL  Q                   
Sbjct: 275  C---MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRIT 331

Query: 829  ----------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSS 872
                            EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K   
Sbjct: 332  TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 391

Query: 873  CD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFC 930
             +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+ 
Sbjct: 392  KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYA 450

Query: 931  KYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEG 990
              GNL  +LRA                             RR PG        R      
Sbjct: 451  SKGNLREYLRA-----------------------------RRPPGMEYSYDINRV----- 476

Query: 991  GARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDV 1050
                  P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E++V
Sbjct: 477  ------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 522

Query: 1051 VKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSL 1110
            +KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF+L
Sbjct: 523  MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 582

Query: 1111 GASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG 1170
            G SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L 
Sbjct: 583  GGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 641

Query: 1171 DLL 1173
             +L
Sbjct: 642  RIL 644



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 51  LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 110

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 111 KGNYTCVVENEYGSINHTYHLDVVERSP 138



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 54  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 113

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 114 YTCVVENEYGSIN 126


>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
            [Homo sapiens]
          Length = 706

 Score =  293 bits (750), Expect = 8e-79
 Identities = 210/605 (34%), Positives = 294/605 (48%), Gaps = 116/605 (19%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 95   RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSN-QKLSI 735
            V   +E  C V     P I W K       K              +GV+  D   + L I
Sbjct: 155  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV--------EGSEDKGSMEIVIL-VGTGVIA 786
            + V  EDAG Y C   N+ G    SA + V        E +     +EI I  +G  +IA
Sbjct: 215  RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274

Query: 787  VFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC------------------ 828
                +++ +I C M+        +   ++      +PL  Q                   
Sbjct: 275  C---MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 331

Query: 829  ------------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG 870
                              EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K 
Sbjct: 332  ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 391

Query: 871  SSCD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVE 928
               +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE
Sbjct: 392  KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVE 450

Query: 929  FCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKT 988
            +   GNL  +LRA                             RR PG        R    
Sbjct: 451  YASKGNLREYLRA-----------------------------RRPPGMEYSYDINRV--- 478

Query: 989  EGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSES 1048
                    P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E+
Sbjct: 479  --------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 522

Query: 1049 DVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIF 1108
            +V+KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF
Sbjct: 523  NVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 582

Query: 1109 SLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEI 1168
            +LG SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE 
Sbjct: 583  TLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 641

Query: 1169 LGDLL 1173
            L  +L
Sbjct: 642  LDRIL 646



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 51  LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 110

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 111 KGNYTCVVENEYGSINHTYHLDVVERSP 138



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 54  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 113

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 114 YTCVVENEYGSIN 126


>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
            [Homo sapiens]
          Length = 821

 Score =  293 bits (750), Expect = 8e-79
 Identities = 210/605 (34%), Positives = 294/605 (48%), Gaps = 116/605 (19%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            R+   SL +  V P  +G+Y C V++      H +   +  ++   P L   L  +    
Sbjct: 210  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSN-QKLSI 735
            V   +E  C V     P I W K       K              +GV+  D   + L I
Sbjct: 270  VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 329

Query: 736  QRVREEDAGRYLCSVCNAKGCVNSSASVAV--------EGSEDKGSMEIVIL-VGTGVIA 786
            + V  EDAG Y C   N+ G    SA + V        E +     +EI I  +G  +IA
Sbjct: 330  RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 389

Query: 787  VFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQC------------------ 828
                +++ +I C M+        +   ++      +PL  Q                   
Sbjct: 390  C---MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 446

Query: 829  ------------------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG 870
                              EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K 
Sbjct: 447  ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 506

Query: 871  SSCD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVE 928
               +  TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE
Sbjct: 507  KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVE 565

Query: 929  FCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKT 988
            +   GNL  +LRA                             RR PG        R    
Sbjct: 566  YASKGNLREYLRA-----------------------------RRPPGMEYSYDINRV--- 593

Query: 989  EGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSES 1048
                    P+++        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E+
Sbjct: 594  --------PEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 637

Query: 1049 DVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIF 1108
            +V+KI DFGLARDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF
Sbjct: 638  NVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 697

Query: 1109 SLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEI 1168
            +LG SPYPG+ + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE 
Sbjct: 698  TLGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 756

Query: 1169 LGDLL 1173
            L  +L
Sbjct: 757  LDRIL 761



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +     L++V   P
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSP 253



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 17/73 (23%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
           V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 228

Query: 746 YLCSVCNAKGCVN 758
           Y C V N  G +N
Sbjct: 229 YTCVVENEYGSIN 241


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  292 bits (748), Expect = 1e-78
 Identities = 209/598 (34%), Positives = 285/598 (47%), Gaps = 109/598 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            RH   SL +  V P   G Y C V++     ++ +   +  ++   P L   L  +    
Sbjct: 203  RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD---------LADSNQK----LSIQR 737
            V   +E+ C V     P I W K   +     G D          AD N      L ++ 
Sbjct: 263  VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRN 322

Query: 738  VREEDAGRYLCSVCNAKGCVNSSASVAVEGSED--------KGSMEIVILVGTGVIAVFF 789
            V  EDAG Y C   N+ G    SA + V   ED        +     +IL  +G +A+  
Sbjct: 323  VSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLAL-- 380

Query: 790  WVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQ------------ 837
              +LLL+    R  A         + +      PL  Q    S  + +            
Sbjct: 381  -AVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLS 439

Query: 838  --------------------WEFPRERLHLGRVLGYGAFGKVVEASAFGIH--KGSSCDT 875
                                WEFPR+RL LG+ LG G FG+VV A AFG+   +     T
Sbjct: 440  SSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAST 499

Query: 876  VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNL 935
            VAVKMLK+ A+  +   L+SE++++  IG H N++NLLG CT+ +GPL VIVE    GNL
Sbjct: 500  VAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQ-EGPLYVIVECAAKGNL 558

Query: 936  SNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRA 995
              FLRA+R    P  + SP+                  P SS+                 
Sbjct: 559  REFLRARRP---PGPDLSPDG-----------------PRSSE----------------- 581

Query: 996  SPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICD 1055
                        PL+   LV  ++QVARGM++L SRKCIHRDLAARN+L++E +V+KI D
Sbjct: 582  -----------GPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIAD 630

Query: 1056 FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPY 1115
            FGLAR ++    Y +  + RLP+KWMAPE++FD+VYT QSDVWSFG+LLWEIF+LG SPY
Sbjct: 631  FGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY 690

Query: 1116 PGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            PG+ + EE    LR+G RM  P    P +  +M  CW   P  RP F +LVE L  +L
Sbjct: 691  PGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A      VK     A  P P  +W KDG+A  G         RH   +LV++ V  + 
Sbjct: 159 LHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSD 218

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            GTYT  + N+   +R N  L+++   P
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSP 246



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 21/72 (29%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKS---GVDLADSNQKLSIQRVREEDAGR 745
           V   ++++ +C  AG   P+I W KD +    ++   G+ L   +  L ++ V   D G 
Sbjct: 162 VPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGT 221

Query: 746 YLCSVCNAKGCV 757
           Y C V NA G +
Sbjct: 222 YTCLVENAVGSI 233


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  292 bits (748), Expect = 1e-78
 Identities = 209/598 (34%), Positives = 285/598 (47%), Gaps = 109/598 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            RH   SL +  V P   G Y C V++     ++ +   +  ++   P L   L  +    
Sbjct: 203  RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD---------LADSNQK----LSIQR 737
            V   +E+ C V     P I W K   +     G D          AD N      L ++ 
Sbjct: 263  VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRN 322

Query: 738  VREEDAGRYLCSVCNAKGCVNSSASVAVEGSED--------KGSMEIVILVGTGVIAVFF 789
            V  EDAG Y C   N+ G    SA + V   ED        +     +IL  +G +A+  
Sbjct: 323  VSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLAL-- 380

Query: 790  WVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQ------------ 837
              +LLL+    R  A         + +      PL  Q    S  + +            
Sbjct: 381  -AVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLS 439

Query: 838  --------------------WEFPRERLHLGRVLGYGAFGKVVEASAFGIH--KGSSCDT 875
                                WEFPR+RL LG+ LG G FG+VV A AFG+   +     T
Sbjct: 440  SSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAST 499

Query: 876  VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNL 935
            VAVKMLK+ A+  +   L+SE++++  IG H N++NLLG CT+ +GPL VIVE    GNL
Sbjct: 500  VAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQ-EGPLYVIVECAAKGNL 558

Query: 936  SNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRA 995
              FLRA+R    P  + SP+                  P SS+                 
Sbjct: 559  REFLRARRP---PGPDLSPDG-----------------PRSSE----------------- 581

Query: 996  SPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICD 1055
                        PL+   LV  ++QVARGM++L SRKCIHRDLAARN+L++E +V+KI D
Sbjct: 582  -----------GPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIAD 630

Query: 1056 FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPY 1115
            FGLAR ++    Y +  + RLP+KWMAPE++FD+VYT QSDVWSFG+LLWEIF+LG SPY
Sbjct: 631  FGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY 690

Query: 1116 PGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            PG+ + EE    LR+G RM  P    P +  +M  CW   P  RP F +LVE L  +L
Sbjct: 691  PGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A      VK     A  P P  +W KDG+A  G         RH   +LV++ V  + 
Sbjct: 159 LHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSD 218

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            GTYT  + N+   +R N  L+++   P
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSP 246



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 21/72 (29%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKS---GVDLADSNQKLSIQRVREEDAGR 745
           V   ++++ +C  AG   P+I W KD +    ++   G+ L   +  L ++ V   D G 
Sbjct: 162 VPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGT 221

Query: 746 YLCSVCNAKGCV 757
           Y C V NA G +
Sbjct: 222 YTCLVENAVGSI 233


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
            [Homo sapiens]
          Length = 762

 Score =  290 bits (743), Expect = 5e-78
 Identities = 206/577 (35%), Positives = 276/577 (47%), Gaps = 107/577 (18%)

Query: 632  RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
            RH   SL +  V P   G Y C V++     ++ +   +  ++   P L   L  +    
Sbjct: 203  RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

Query: 691  VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD---------LADSNQK----LSIQR 737
            V   +E+ C V     P I W K   +     G D          AD N      L ++ 
Sbjct: 263  VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRN 322

Query: 738  VREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIF 797
            V  EDAG Y C   N+ G    SA + V             L GTG I          + 
Sbjct: 323  VSAEDAGEYTCLAGNSIGLSYQSAWLTV-------------LPGTGRIPH--------LT 361

Query: 798  CNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQ-------------------W 838
            C+   PA    K+  L   ++ G               S                    W
Sbjct: 362  CDSLTPA-GRTKSPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLW 420

Query: 839  EFPRERLHLGRVLGYGAFGKVVEASAFGIH--KGSSCDTVAVKMLKEGATASEHRALMSE 896
            EFPR+RL LG+ LG G FG+VV A AFG+   +     TVAVKMLK+ A+  +   L+SE
Sbjct: 421  EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 480

Query: 897  LKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQ 956
            ++++  IG H N++NLLG CT+ +GPL VIVE    GNL  FLRA+R    P  + SP+ 
Sbjct: 481  MEVMKLIGRHKNIINLLGVCTQ-EGPLYVIVECAAKGNLREFLRARRP---PGPDLSPDG 536

Query: 957  RGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVC 1016
                             P SS+                             PL+   LV 
Sbjct: 537  -----------------PRSSE----------------------------GPLSFPVLVS 551

Query: 1017 YSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARL 1076
             ++QVARGM++L SRKCIHRDLAARN+L++E +V+KI DFGLAR ++    Y +  + RL
Sbjct: 552  CAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRL 611

Query: 1077 PLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRA 1136
            P+KWMAPE++FD+VYT QSDVWSFG+LLWEIF+LG SPYPG+ + EE    LR+G RM  
Sbjct: 612  PVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPV-EELFSLLREGHRMDR 670

Query: 1137 PELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            P    P +  +M  CW   P  RP F +LVE L  +L
Sbjct: 671  PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A      VK     A  P P  +W KDG+A  G         RH   +LV++ V  + 
Sbjct: 159 LHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSD 218

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            GTYT  + N+   +R N  L+++   P
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSP 246



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 21/72 (29%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 689 VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKS---GVDLADSNQKLSIQRVREEDAGR 745
           V   ++++ +C  AG   P+I W KD +    ++   G+ L   +  L ++ V   D G 
Sbjct: 162 VPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGT 221

Query: 746 YLCSVCNAKGCV 757
           Y C V NA G +
Sbjct: 222 YTCLVENAVGSI 233


>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
            [Homo sapiens]
          Length = 709

 Score =  287 bits (735), Expect = 4e-77
 Identities = 190/534 (35%), Positives = 277/534 (51%), Gaps = 102/534 (19%)

Query: 689  VNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDAGR 745
            V  +++++ +C   G   P++ W K+ +  +++    G  + + +  L ++ V   D G 
Sbjct: 169  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 228

Query: 746  YLCSVCNAKGCVNSS--ASVAVEGSEDKGS-----MEIVIL-VGTGVIAVFFWVLLLLIF 797
            Y C V N  G +N +    V   G E + +     +EI I  +G  +IA    +++ +I 
Sbjct: 229  YTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIAC---MVVTVIL 285

Query: 798  CNMRRPAHADIKTGYLSIIMDPGEVPLEEQC----------------------------- 828
            C M+        +   ++      +PL  Q                              
Sbjct: 286  CRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADT 345

Query: 829  -------EYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCD--TVAVK 879
                   EY   +  +WEFPR++L LG+ LG G FG+VV A A GI K    +  TVAVK
Sbjct: 346  PMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVK 405

Query: 880  MLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFL 939
            MLK+ AT  +   L+SE++++  IG H N++NLLGACT+  GPL VIVE+   GNL  +L
Sbjct: 406  MLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYL 464

Query: 940  RAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQ 999
            RA                             RR PG        R            P++
Sbjct: 465  RA-----------------------------RRPPGMEYSYDINRV-----------PEE 484

Query: 1000 EAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLA 1059
            +        +T +DLV  ++Q+ARGME+LAS+KCIHRDLAARN+L++E++V+KI DFGLA
Sbjct: 485  Q--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 536

Query: 1060 RDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQ 1119
            RDI     Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVL+WEIF+LG SPYPG+ 
Sbjct: 537  RDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 596

Query: 1120 INEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            + EE  + L++G RM  P   T  +  +M +CW   P  RP F +LVE L  +L
Sbjct: 597  V-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 649



 Score = 32.0 bits (71), Expect = 4.2
 Identities = 20/84 (23%), Positives = 32/84 (38%), Gaps = 9/84 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRH--------SPH-ALVLKEVTEAS 393
           L A      VK        P P  +W K+GK     H        + H +L+++ V  + 
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 394 TGTYTLALWNSAAGLRRNISLELV 417
            G YT  + N    +     L++V
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVV 249


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
            [Homo sapiens]
          Length = 694

 Score =  284 bits (726), Expect = 5e-76
 Identities = 193/532 (36%), Positives = 267/532 (50%), Gaps = 100/532 (18%)

Query: 687  LLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEK---SGVDLADSNQKLSIQRVREEDA 743
            L V  ++++  +C  AG   PSI W K+ R    +    G+ L      L ++ V   D 
Sbjct: 164  LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223

Query: 744  GRYLCSVCNAKGCVNSSASV---------------------AVEGSEDKGSMEIV----- 777
            G Y C V N  G +  + ++                     AV GS+ +   ++      
Sbjct: 224  GNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQP 283

Query: 778  -------ILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSII-MDPGEVPLEEQCE 829
                   + V    +       + ++  ++   A     T  + I  +  GE P      
Sbjct: 284  HIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVS 343

Query: 830  YLSYDAS-QWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCD--TVAVKMLKEGAT 886
             L   A  +WE  R RL LG+ LG G FG+VV A A GI K  +    TVAVKMLK+ AT
Sbjct: 344  ELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDAT 403

Query: 887  ASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRD-- 944
              +   L+SE++++  IG H N++NLLGACT+  GPL V+VE+   GNL  FLRA+R   
Sbjct: 404  DKDLSDLVSEMEMMKMIGKHKNIINLLGACTQG-GPLYVLVEYAAKGNLREFLRARRPPG 462

Query: 945  ---AFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEA 1001
               +F  C  K PE++                                            
Sbjct: 463  LDYSFDTC--KPPEEQ-------------------------------------------- 476

Query: 1002 EDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARD 1061
                   LT +DLV  ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI DFGLARD
Sbjct: 477  -------LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 529

Query: 1062 IYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIN 1121
            ++    Y +  + RLP+KWMAPE++FD+VYT QSDVWSFGVLLWEIF+LG SPYPG+ + 
Sbjct: 530  VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV- 588

Query: 1122 EEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLL 1173
            EE  + L++G RM  P   T  +  IM  CW   P  RP F +LVE L  +L
Sbjct: 589  EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 640



 Score = 38.5 bits (88), Expect = 0.044
 Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 9/88 (10%)

Query: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
           L A      V+     A  P P   W K+G+   G         RH   +LV++ V  + 
Sbjct: 163 LLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSD 222

Query: 394 TGTYTLALWNSAAGLRRNISLELVVNVP 421
            G YT  + N    +R+  +L+++   P
Sbjct: 223 RGNYTCVVENKFGSIRQTYTLDVLERSP 250



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 23/95 (24%), Positives = 37/95 (38%), Gaps = 1/95 (1%)

Query: 632 RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
           RH   SL +  V P   G+Y C V+++    +  +   +  ++   P L   L  +    
Sbjct: 207 RHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAV 266

Query: 691 VSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVD 725
           +   +E  C V     P I W K   +   K G D
Sbjct: 267 LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPD 301


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,731,220
Number of Sequences: 37866
Number of extensions: 2604770
Number of successful extensions: 12933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 639
Number of HSP's successfully gapped in prelim test: 398
Number of HSP's that attempted gapping in prelim test: 6808
Number of HSP's gapped (non-prelim): 4465
length of query: 1363
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1248
effective length of database: 13,892,928
effective search space: 17338374144
effective search space used: 17338374144
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.