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Search of human proteins with 18104989
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
(595 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 1216 0.0
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 1211 0.0
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 1144 0.0
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 654 0.0
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 204 1e-52
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 204 1e-52
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 204 2e-52
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 204 2e-52
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 197 3e-50
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 197 3e-50
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 197 3e-50
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 197 3e-50
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 195 1e-49
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 195 1e-49
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 195 1e-49
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 195 1e-49
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 195 1e-49
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 195 1e-49
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 195 1e-49
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 191 2e-48
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 191 2e-48
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 191 2e-48
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 191 2e-48
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 191 2e-48
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 190 3e-48
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 190 4e-48
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 190 4e-48
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 190 4e-48
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 190 4e-48
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 190 4e-48
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 1216 bits (3146), Expect = 0.0
Identities = 595/595 (100%), Positives = 595/595 (100%)
Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60
Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120
Query: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
Sbjct: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
Query: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
Sbjct: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360
Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
Sbjct: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420
Query: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
Sbjct: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480
Query: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
Sbjct: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540
Query: 541 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Sbjct: 541 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 1211 bits (3132), Expect = 0.0
Identities = 592/592 (100%), Positives = 592/592 (100%)
Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63
WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL
Sbjct: 6 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 65
Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETL 123
YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETL
Sbjct: 66 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETL 125
Query: 124 LQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLET 183
LQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLET
Sbjct: 126 LQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLET 185
Query: 184 FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAG 243
FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAG
Sbjct: 186 FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAG 245
Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303
FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN
Sbjct: 246 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 305
Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363
ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP
Sbjct: 306 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 365
Query: 364 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423
YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP
Sbjct: 366 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 425
Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483
SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID
Sbjct: 426 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 485
Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPP 543
IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPP
Sbjct: 486 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPP 545
Query: 544 AMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595
AMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Sbjct: 546 AMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 597
Score = 66.6 bits (161), Expect = 6e-11
Identities = 40/107 (37%), Positives = 61/107 (57%), Gaps = 13/107 (12%)
Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQ----------VTHI 52
RW+H +SG AETLL+ +G +FL R S GDF LSV + DQ VTHI
Sbjct: 111 RWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSV-LSDQPKAGPGSPLRVTHI 169
Query: 53 RIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99
++ G Y + G E F +LT+LVE++ ++ +++ G ++L+ P
Sbjct: 170 KVMCEGGRYTVGGLETFDSLTDLVEHF--KKTGIEEASGAFVYLRQP 214
Score = 65.5 bits (158), Expect = 1e-10
Identities = 40/109 (36%), Positives = 61/109 (55%), Gaps = 13/109 (11%)
Query: 107 SERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSV-LSDQPKAGPGSPLRVT 165
S W+H +SG AETLL+ +G +FL R S GDF LSV + DQ VT
Sbjct: 3 SRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQ----------VT 52
Query: 166 HIKVMCEGGRYTVGGLETFDSLTDLVEHF--KKTGIEEASGAFVYLRQP 212
HI++ G Y + G E F +LT+LVE++ ++ +++ G ++L+ P
Sbjct: 53 HIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 101
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 1144 bits (2958), Expect = 0.0
Identities = 559/561 (99%), Positives = 559/561 (99%)
Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60
Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120
Query: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
Sbjct: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
Query: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
Sbjct: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360
Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
Sbjct: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420
Query: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
Sbjct: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480
Query: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
Sbjct: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540
Query: 541 YPPAMKNAHAKASRTSSKHKE 561
YPPAMKNAHAKASRTSSK E
Sbjct: 541 YPPAMKNAHAKASRTSSKSLE 561
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 654 bits (1687), Expect = 0.0
Identities = 319/544 (58%), Positives = 410/544 (75%), Gaps = 6/544 (1%)
Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62
RWFH +++G++AE LL RGV GSFLARPS+ N GDF+LSVR VTHI+IQN+GD+YD
Sbjct: 5 RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64
Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAET 122
LYGGEKFATL ELV+YY + G L++++G +I LKYPLNC+DPTSERW+HGH+SG +AE
Sbjct: 65 LYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEK 124
Query: 123 LLQAKGEPWTFLVRESLSQPGDFVLSVLS--DQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
LL KG+ +FLVRES S PGDFVLSV + D+ ++ G +VTH+ + C+ +Y VGG
Sbjct: 125 LLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKS-KVTHVMIRCQELKYDVGG 183
Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
E FDSLTDLVEH+KK + E G + L+QP TR+NAA+IE+RV EL+K E+ D
Sbjct: 184 GERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKV 243
Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N P SD
Sbjct: 244 KQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSD 303
Query: 301 YINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKG 357
YINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+EVE+G
Sbjct: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
Query: 358 RNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSW 417
++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y + +W
Sbjct: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477
PDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I KG
Sbjct: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYG 537
+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET ++++E Q K + EY
Sbjct: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYT 543
Query: 538 NITY 541
NI Y
Sbjct: 544 NIKY 547
Score = 68.2 bits (165), Expect = 2e-11
Identities = 43/119 (36%), Positives = 65/119 (54%), Gaps = 16/119 (13%)
Query: 106 TSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165
TS RW+H +++G +AE LL +G +FL R S S PGDF LSV + VT
Sbjct: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNG---------AVT 52
Query: 166 HIKVMCEGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLRQPYYATRVNAAD 222
HIK+ G Y + G E F +L +LV+++ + ++E +G + L+ P +N AD
Sbjct: 53 HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP-----LNCAD 106
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 204 bits (520), Expect = 1e-52
Identities = 123/297 (41%), Positives = 168/297 (56%), Gaps = 23/297 (7%)
Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277
+ AD+ + ++ + Q GF EE+E+L + + + E EN+ KNRY
Sbjct: 869 IRVADLLQHITQMKRGQGY------GFKEEYEALPEGQTASWDTAKED---ENRNKNRYG 919
Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337
NI+ +DHSRV L D + P SDYINANYI + YIA+QG ++ TV DFW+
Sbjct: 920 NIISYDHSRVRLLVLDGD-PHSDYINANYIDGY-----HRPRHYIATQGPMQETVKDFWR 973
Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397
M WQENS IVM T VE GR KCV YWP+ YG VT EY +RT V
Sbjct: 974 MIWQENSASIVMVTNLVEVGRVKCVRYWPD--DTEVYGDIKVTLIETEPLAEYVIRTFTV 1031
Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457
+ IRE+ + + SWPDHGVP G+L F+ Q+ + + P AGPI+VHCSAG
Sbjct: 1032 QKKGYHE-IRELRLFHFTSWPDHGVPCYATGLLGFVRQV--KFLNPPEAGPIVVHCSAGA 1088
Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
GRTG I ID +++ +G+ +DI ++ +RAQR +VQTE QY F++ AI +
Sbjct: 1089 GRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1142
Score = 99.4 bits (246), Expect = 8e-21
Identities = 98/394 (24%), Positives = 157/394 (39%), Gaps = 57/394 (14%)
Query: 154 PKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPY 213
P+AGP I V C G G D++ D+ E+ G+ + LR
Sbjct: 1075 PEAGP--------IVVHCSAGAGRTGCFIAIDTMLDMAEN---EGVVDIFNCVRELR--- 1120
Query: 214 YATRVNAADIEN-------------------------RVLELNKKQESEDTAKAGFWEEF 248
A RVN E R L N + T + +EF
Sbjct: 1121 -AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEF 1179
Query: 249 ESLQKQEVKNLHQRLE-GQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYI 307
++L + + G P N KNR ++LP D L D ++NYI
Sbjct: 1180 QTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE-------SSNYI 1232
Query: 308 KNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE 367
L+ + ++ +Q L TV DFW++ + N +VM E++ + C+ YWPE
Sbjct: 1233 NAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVM-LNEMDTAQ-FCMQYWPE 1290
Query: 368 VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDN-GDLIREIWHYQYLSWPDH-GVPSE 425
YGP V + R ++ + D R + H QY+ WP + P
Sbjct: 1291 -KTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPS 1349
Query: 426 PGGVLSFLDQINQRQESLP-HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDI 484
+L + ++ + QE G +VHC G GR+GT I + E I + + ID+
Sbjct: 1350 KRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDV 1406
Query: 485 QKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518
++ +R +S MV+T QYKF+Y +++ +
Sbjct: 1407 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 204 bits (520), Expect = 1e-52
Identities = 123/297 (41%), Positives = 168/297 (56%), Gaps = 23/297 (7%)
Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277
+ AD+ + ++ + Q GF EE+E+L + + + E EN+ KNRY
Sbjct: 888 IRVADLLQHITQMKRGQGY------GFKEEYEALPEGQTASWDTAKED---ENRNKNRYG 938
Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337
NI+ +DHSRV L D + P SDYINANYI + YIA+QG ++ TV DFW+
Sbjct: 939 NIISYDHSRVRLLVLDGD-PHSDYINANYIDGY-----HRPRHYIATQGPMQETVKDFWR 992
Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397
M WQENS IVM T VE GR KCV YWP+ YG VT EY +RT V
Sbjct: 993 MIWQENSASIVMVTNLVEVGRVKCVRYWPD--DTEVYGDIKVTLIETEPLAEYVIRTFTV 1050
Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457
+ IRE+ + + SWPDHGVP G+L F+ Q+ + + P AGPI+VHCSAG
Sbjct: 1051 QKKGYHE-IRELRLFHFTSWPDHGVPCYATGLLGFVRQV--KFLNPPEAGPIVVHCSAGA 1107
Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
GRTG I ID +++ +G+ +DI ++ +RAQR +VQTE QY F++ AI +
Sbjct: 1108 GRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1161
Score = 99.4 bits (246), Expect = 8e-21
Identities = 98/394 (24%), Positives = 157/394 (39%), Gaps = 57/394 (14%)
Query: 154 PKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPY 213
P+AGP I V C G G D++ D+ E+ G+ + LR
Sbjct: 1094 PEAGP--------IVVHCSAGAGRTGCFIAIDTMLDMAEN---EGVVDIFNCVRELR--- 1139
Query: 214 YATRVNAADIEN-------------------------RVLELNKKQESEDTAKAGFWEEF 248
A RVN E R L N + T + +EF
Sbjct: 1140 -AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEF 1198
Query: 249 ESLQKQEVKNLHQRLE-GQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYI 307
++L + + G P N KNR ++LP D L D ++NYI
Sbjct: 1199 QTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE-------SSNYI 1251
Query: 308 KNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE 367
L+ + ++ +Q L TV DFW++ + N +VM E++ + C+ YWPE
Sbjct: 1252 NAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVM-LNEMDTAQ-FCMQYWPE 1309
Query: 368 VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDN-GDLIREIWHYQYLSWPDH-GVPSE 425
YGP V + R ++ + D R + H QY+ WP + P
Sbjct: 1310 -KTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPS 1368
Query: 426 PGGVLSFLDQINQRQESLP-HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDI 484
+L + ++ + QE G +VHC G GR+GT I + E I + + ID+
Sbjct: 1369 KRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDV 1425
Query: 485 QKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518
++ +R +S MV+T QYKF+Y +++ +
Sbjct: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 204 bits (519), Expect = 2e-52
Identities = 125/331 (37%), Positives = 182/331 (54%), Gaps = 30/331 (9%)
Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
GF EE+ES + + + ++ +N+ KNRY NI+ +DHSRVILQ + + P SDYI
Sbjct: 887 GFKEEYESFFEGQSASWDV---AKKDQNRAKNRYGNIIAYDHSRVILQPVEDD-PSSDYI 942
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
NANYI + YIA+QG + TV DFW+M WQE S IVM T VE GR KC
Sbjct: 943 NANYIDGY-----QRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCY 997
Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422
YWP+ YG + VT EY +RT + + IRE+ + + WPDHGV
Sbjct: 998 KYWPD--DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE-IREVKQFHFTGWPDHGV 1054
Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482
P G+LSF+ ++ + + P AGPI+VHCSAG GRTG IVID++++ +G+ +
Sbjct: 1055 PYHATGLLSFIRRV--KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---V 1109
Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYP 542
DI ++ +R++R MVQTE QY FI+ AI + + + V + +
Sbjct: 1110 DIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCE-------------FK 1156
Query: 543 PAMKNAHAKASRTSSKHKEDVYENLHTKNKR 573
A + S+T+S H +D ++ L++ R
Sbjct: 1157 AAYFDMIRIDSQTNSSHLKDEFQTLNSVTPR 1187
Score = 102 bits (253), Expect = 1e-21
Identities = 104/394 (26%), Positives = 161/394 (40%), Gaps = 47/394 (11%)
Query: 150 LSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYL 209
LS+ P AGP I V C G G D + D+ E I A
Sbjct: 1070 LSNPPSAGP--------IVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR 1121
Query: 210 RQPYYATRVNAADIENRVLELNKKQESEDTA---KAGFWEEFE-------SLQKQEVKNL 259
R T I + +LE E+ KA +++ S K E + L
Sbjct: 1122 RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTL 1181
Query: 260 HQ---RLEGQR------PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQ 310
+ RL+ + P N KNR+ ++LP D L D ++NYI
Sbjct: 1182 NSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGE-------SSNYINAA 1234
Query: 311 LLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM 370
L+ +I +Q L TV DFW++ + IVM EV+ + C YWPE GM
Sbjct: 1235 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM-LNEVDLSQG-CPQYWPEEGM 1292
Query: 371 QRAYGPYSV--TNCG-EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH-GVPSEP 426
R YGP V +C + D R ++ G L+ + +QYL W H VP
Sbjct: 1293 LR-YGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLM--VQQFQYLGWASHREVPGSK 1349
Query: 427 GGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQ 485
L + Q+ + QE G I+HC G GR+G I +++E + + + +D+
Sbjct: 1350 RSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV---VDVF 1406
Query: 486 KTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT 519
++ +R + MV+ QY+F Y +++E++
Sbjct: 1407 HAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1440
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 204 bits (518), Expect = 2e-52
Identities = 126/332 (37%), Positives = 183/332 (55%), Gaps = 26/332 (7%)
Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
GF EE+ES + + + ++ +N+ KNRY NI+ +DHSRVILQ + + P SDYI
Sbjct: 887 GFKEEYESFFEGQSASWDV---AKKDQNRAKNRYGNIIAYDHSRVILQPVEDD-PSSDYI 942
Query: 303 NANYIKNQLLGPD-ENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC 361
NANYI L + YIA+QG + TV DFW+M WQE S IVM T VE GR KC
Sbjct: 943 NANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKC 1002
Query: 362 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG 421
YWP+ YG + VT EY +RT + + IRE+ + + WPDHG
Sbjct: 1003 YKYWPD--DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE-IREVKQFHFTGWPDHG 1059
Query: 422 VPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD 481
VP G+LSF+ ++ + + P AGPI+VHCSAG GRTG IVID++++ +G+
Sbjct: 1060 VPYHATGLLSFIRRV--KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV--- 1114
Query: 482 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITY 541
+DI ++ +R++R MVQTE QY FI+ AI + + + V + +
Sbjct: 1115 VDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCE-------------F 1161
Query: 542 PPAMKNAHAKASRTSSKHKEDVYENLHTKNKR 573
A + S+T+S H +D ++ L++ R
Sbjct: 1162 KAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPR 1193
Score = 102 bits (253), Expect = 1e-21
Identities = 104/394 (26%), Positives = 161/394 (40%), Gaps = 47/394 (11%)
Query: 150 LSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYL 209
LS+ P AGP I V C G G D + D+ E I A
Sbjct: 1076 LSNPPSAGP--------IVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR 1127
Query: 210 RQPYYATRVNAADIENRVLELNKKQESEDTA---KAGFWEEFE-------SLQKQEVKNL 259
R T I + +LE E+ KA +++ S K E + L
Sbjct: 1128 RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTL 1187
Query: 260 HQ---RLEGQR------PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQ 310
+ RL+ + P N KNR+ ++LP D L D ++NYI
Sbjct: 1188 NSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGE-------SSNYINAA 1240
Query: 311 LLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM 370
L+ +I +Q L TV DFW++ + IVM EV+ + C YWPE GM
Sbjct: 1241 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM-LNEVDLSQG-CPQYWPEEGM 1298
Query: 371 QRAYGPYSV--TNCG-EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH-GVPSEP 426
R YGP V +C + D R ++ G L+ + +QYL W H VP
Sbjct: 1299 LR-YGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLM--VQQFQYLGWASHREVPGSK 1355
Query: 427 GGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQ 485
L + Q+ + QE G I+HC G GR+G I +++E + + + +D+
Sbjct: 1356 RSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV---VDVF 1412
Query: 486 KTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT 519
++ +R + MV+ QY+F Y +++E++
Sbjct: 1413 HAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1446
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 197 bits (500), Expect = 3e-50
Identities = 120/292 (41%), Positives = 167/292 (57%), Gaps = 30/292 (10%)
Query: 225 NRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDH 284
N L+L+++ ES D + WE H LE NK KNRY N++ +DH
Sbjct: 945 NDSLKLSQEYESIDPGQQFTWE-------------HSNLE----VNKPKNRYANVIAYDH 987
Query: 285 SRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENS 344
SRVILQ + I GSDYINANY+ +NA YIA+QG L T DFW+M W++ S
Sbjct: 988 SRVILQPIEG-IMGSDYINANYVDGYRC---QNA--YIATQGPLPETFGDFWRMVWEQRS 1041
Query: 345 RVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD 404
IVM TR EK R KC YWP G + YG VT + + +RT + + +
Sbjct: 1042 ATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFCVRTFSLHKNGSSE 1100
Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464
RE+ +Q+ +WPDHGVP P L+FL ++ + + P AGPI+VHCSAG+GRTG I
Sbjct: 1101 K-REVRQFQFTAWPDHGVPEYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFI 1157
Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516
VID ++E I + +D+ + ++R+QR+ MVQTE QY FI+ A+ + +
Sbjct: 1158 VIDAMLERIKP---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206
Score = 187 bits (476), Expect = 2e-47
Identities = 108/301 (35%), Positives = 166/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A + + +L + + E G EF+ L + + + + P NK KNR
Sbjct: 1211 TEVPARSLYAYIQKLAQVEPGEHVT--GMELEFKRLANSKA-HTSRFISANLPCNKFKNR 1267
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1268 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1321
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1322 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1380
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1381 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1439
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE +Y+F Y A ++
Sbjct: 1440 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1496
Query: 516 I 516
+
Sbjct: 1497 L 1497
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 197 bits (500), Expect = 3e-50
Identities = 120/292 (41%), Positives = 167/292 (57%), Gaps = 30/292 (10%)
Query: 225 NRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDH 284
N L+L+++ ES D + WE H LE NK KNRY N++ +DH
Sbjct: 1350 NDSLKLSQEYESIDPGQQFTWE-------------HSNLE----VNKPKNRYANVIAYDH 1392
Query: 285 SRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENS 344
SRVILQ + I GSDYINANY+ +NA YIA+QG L T DFW+M W++ S
Sbjct: 1393 SRVILQPIEG-IMGSDYINANYVDGYRC---QNA--YIATQGPLPETFGDFWRMVWEQRS 1446
Query: 345 RVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD 404
IVM TR EK R KC YWP G + YG VT + + +RT + + +
Sbjct: 1447 ATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFCVRTFSLHKNGSSE 1505
Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464
RE+ +Q+ +WPDHGVP P L+FL ++ + + P AGPI+VHCSAG+GRTG I
Sbjct: 1506 K-REVRQFQFTAWPDHGVPEYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFI 1562
Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516
VID ++E I + +D+ + ++R+QR+ MVQTE QY FI+ A+ + +
Sbjct: 1563 VIDAMLERIKP---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1611
Score = 187 bits (476), Expect = 2e-47
Identities = 108/301 (35%), Positives = 166/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A + + +L + + E G EF+ L + + + + P NK KNR
Sbjct: 1616 TEVPARSLYAYIQKLAQVEPGEHVT--GMELEFKRLANSKA-HTSRFISANLPCNKFKNR 1672
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1673 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1726
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1727 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1785
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1786 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1844
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE +Y+F Y A ++
Sbjct: 1845 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1901
Query: 516 I 516
+
Sbjct: 1902 L 1902
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 197 bits (500), Expect = 3e-50
Identities = 120/292 (41%), Positives = 167/292 (57%), Gaps = 30/292 (10%)
Query: 225 NRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDH 284
N L+L+++ ES D + WE H LE NK KNRY N++ +DH
Sbjct: 941 NDSLKLSQEYESIDPGQQFTWE-------------HSNLE----VNKPKNRYANVIAYDH 983
Query: 285 SRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENS 344
SRVILQ + I GSDYINANY+ +NA YIA+QG L T DFW+M W++ S
Sbjct: 984 SRVILQPIEG-IMGSDYINANYVDGYRC---QNA--YIATQGPLPETFGDFWRMVWEQRS 1037
Query: 345 RVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD 404
IVM TR EK R KC YWP G + YG VT + + +RT + + +
Sbjct: 1038 ATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFCVRTFSLHKNGSSE 1096
Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464
RE+ +Q+ +WPDHGVP P L+FL ++ + + P AGPI+VHCSAG+GRTG I
Sbjct: 1097 K-REVRQFQFTAWPDHGVPEYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFI 1153
Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516
VID ++E I + +D+ + ++R+QR+ MVQTE QY FI+ A+ + +
Sbjct: 1154 VIDAMLERIKP---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202
Score = 187 bits (476), Expect = 2e-47
Identities = 108/301 (35%), Positives = 166/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A + + +L + + E G EF+ L + + + + P NK KNR
Sbjct: 1207 TEVPARSLYAYIQKLAQVEPGEHVT--GMELEFKRLANSKA-HTSRFISANLPCNKFKNR 1263
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1264 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1317
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1318 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1376
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1377 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1435
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE +Y+F Y A ++
Sbjct: 1436 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1492
Query: 516 I 516
+
Sbjct: 1493 L 1493
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 197 bits (500), Expect = 3e-50
Identities = 120/292 (41%), Positives = 167/292 (57%), Gaps = 30/292 (10%)
Query: 225 NRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDH 284
N L+L+++ ES D + WE H LE NK KNRY N++ +DH
Sbjct: 1388 NDSLKLSQEYESIDPGQQFTWE-------------HSNLE----VNKPKNRYANVIAYDH 1430
Query: 285 SRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENS 344
SRVILQ + I GSDYINANY+ +NA YIA+QG L T DFW+M W++ S
Sbjct: 1431 SRVILQPIEG-IMGSDYINANYVDGYRC---QNA--YIATQGPLPETFGDFWRMVWEQRS 1484
Query: 345 RVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD 404
IVM TR EK R KC YWP G + YG VT + + +RT + + +
Sbjct: 1485 ATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFCVRTFSLHKNGSSE 1543
Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464
RE+ +Q+ +WPDHGVP P L+FL ++ + + P AGPI+VHCSAG+GRTG I
Sbjct: 1544 K-REVRQFQFTAWPDHGVPEYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFI 1600
Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516
VID ++E I + +D+ + ++R+QR+ MVQTE QY FI+ A+ + +
Sbjct: 1601 VIDAMLERIKP---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649
Score = 187 bits (476), Expect = 2e-47
Identities = 108/301 (35%), Positives = 166/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A + + +L + + E G EF+ L + + + + P NK KNR
Sbjct: 1654 TEVPARSLYAYIQKLAQVEPGEHVT--GMELEFKRLANSKA-HTSRFISANLPCNKFKNR 1710
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1711 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1764
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1823
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1824 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1882
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE +Y+F Y A ++
Sbjct: 1883 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1939
Query: 516 I 516
+
Sbjct: 1940 L 1940
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 195 bits (495), Expect = 1e-49
Identities = 122/314 (38%), Positives = 178/314 (56%), Gaps = 23/314 (7%)
Query: 207 VYLRQPYYATRVNAADIENRVLELN---KKQESEDTAKAGFWEEFESLQK-QEVKNLHQR 262
V LR+ + T A+ +LEL ++ ++ D K F +E+ES+ Q+ H
Sbjct: 909 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLK--FSQEYESIDPGQQFTWEHSN 966
Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322
LE NK KNRY N++ +DHSRV+L + IPGSDY+NANYI YI
Sbjct: 967 LE----VNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYI 1016
Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382
A+QG L T DFW+M W++ S +VM T+ E+ R KC YWP G + +G VT
Sbjct: 1017 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLL 1075
Query: 383 GEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES 442
+ Y +RT + + + RE+ +Q+ +WPDHGVP P L+FL ++ + +
Sbjct: 1076 DTVELATYCVRTFALYKNGSSEK-REVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCN 1132
Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502
P AGP++VHCSAG+GRTG IVID ++E I + +DI + ++RAQR+ MVQTE
Sbjct: 1133 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTE 1189
Query: 503 AQYKFIYVAIAQFI 516
QY FI+ A+ + +
Sbjct: 1190 DQYIFIHDALLEAV 1203
Score = 189 bits (481), Expect = 5e-48
Identities = 109/301 (36%), Positives = 168/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A ++ + +L + + E+ G EF+ L + + + + P NK KNR
Sbjct: 1208 TEVPARNLYAYIQKLTQIETGENVT--GMELEFKRLASSKA-HTSRFISANLPCNKFKNR 1264
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1265 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1318
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1319 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1377
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1378 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1436
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE QY+F Y A ++
Sbjct: 1437 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1493
Query: 516 I 516
+
Sbjct: 1494 L 1494
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 195 bits (495), Expect = 1e-49
Identities = 122/314 (38%), Positives = 178/314 (56%), Gaps = 23/314 (7%)
Query: 207 VYLRQPYYATRVNAADIENRVLELN---KKQESEDTAKAGFWEEFESLQK-QEVKNLHQR 262
V LR+ + T A+ +LEL ++ ++ D K F +E+ES+ Q+ H
Sbjct: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLK--FSQEYESIDPGQQFTWEHSN 1376
Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322
LE NK KNRY N++ +DHSRV+L + IPGSDY+NANYI YI
Sbjct: 1377 LE----VNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYI 1426
Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382
A+QG L T DFW+M W++ S +VM T+ E+ R KC YWP G + +G VT
Sbjct: 1427 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLL 1485
Query: 383 GEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES 442
+ Y +RT + + + RE+ +Q+ +WPDHGVP P L+FL ++ + +
Sbjct: 1486 DTVELATYCVRTFALYKNGSSEK-REVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCN 1542
Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502
P AGP++VHCSAG+GRTG IVID ++E I + +DI + ++RAQR+ MVQTE
Sbjct: 1543 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTE 1599
Query: 503 AQYKFIYVAIAQFI 516
QY FI+ A+ + +
Sbjct: 1600 DQYIFIHDALLEAV 1613
Score = 189 bits (481), Expect = 5e-48
Identities = 109/301 (36%), Positives = 168/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A ++ + +L + + E+ G EF+ L + + + + P NK KNR
Sbjct: 1618 TEVPARNLYAYIQKLTQIETGENVT--GMELEFKRLASSKA-HTSRFISANLPCNKFKNR 1674
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1675 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1728
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1729 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1787
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1788 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1846
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE QY+F Y A ++
Sbjct: 1847 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1903
Query: 516 I 516
+
Sbjct: 1904 L 1904
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 195 bits (495), Expect = 1e-49
Identities = 122/314 (38%), Positives = 178/314 (56%), Gaps = 23/314 (7%)
Query: 207 VYLRQPYYATRVNAADIENRVLELN---KKQESEDTAKAGFWEEFESLQK-QEVKNLHQR 262
V LR+ + T A+ +LEL ++ ++ D K F +E+ES+ Q+ H
Sbjct: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLK--FSQEYESIDPGQQFTWEHSN 1363
Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322
LE NK KNRY N++ +DHSRV+L + IPGSDY+NANYI YI
Sbjct: 1364 LE----VNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYI 1413
Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382
A+QG L T DFW+M W++ S +VM T+ E+ R KC YWP G + +G VT
Sbjct: 1414 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLL 1472
Query: 383 GEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES 442
+ Y +RT + + + RE+ +Q+ +WPDHGVP P L+FL ++ + +
Sbjct: 1473 DTVELATYCVRTFALYKNGSSEK-REVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCN 1529
Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502
P AGP++VHCSAG+GRTG IVID ++E I + +DI + ++RAQR+ MVQTE
Sbjct: 1530 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTE 1586
Query: 503 AQYKFIYVAIAQFI 516
QY FI+ A+ + +
Sbjct: 1587 DQYIFIHDALLEAV 1600
Score = 189 bits (481), Expect = 5e-48
Identities = 109/301 (36%), Positives = 168/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A ++ + +L + + E+ G EF+ L + + + + P NK KNR
Sbjct: 1605 TEVPARNLYAYIQKLTQIETGENVT--GMELEFKRLASSKA-HTSRFISANLPCNKFKNR 1661
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1662 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1715
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1716 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1774
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1775 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1833
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE QY+F Y A ++
Sbjct: 1834 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1890
Query: 516 I 516
+
Sbjct: 1891 L 1891
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 195 bits (495), Expect = 1e-49
Identities = 122/314 (38%), Positives = 178/314 (56%), Gaps = 23/314 (7%)
Query: 207 VYLRQPYYATRVNAADIENRVLELN---KKQESEDTAKAGFWEEFESLQK-QEVKNLHQR 262
V LR+ + T A+ +LEL ++ ++ D K F +E+ES+ Q+ H
Sbjct: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLK--FSQEYESIDPGQQFTWEHSN 1367
Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322
LE NK KNRY N++ +DHSRV+L + IPGSDY+NANYI YI
Sbjct: 1368 LE----VNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYI 1417
Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382
A+QG L T DFW+M W++ S +VM T+ E+ R KC YWP G + +G VT
Sbjct: 1418 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLL 1476
Query: 383 GEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES 442
+ Y +RT + + + RE+ +Q+ +WPDHGVP P L+FL ++ + +
Sbjct: 1477 DTVELATYCVRTFALYKNGSSEK-REVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCN 1533
Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502
P AGP++VHCSAG+GRTG IVID ++E I + +DI + ++RAQR+ MVQTE
Sbjct: 1534 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTE 1590
Query: 503 AQYKFIYVAIAQFI 516
QY FI+ A+ + +
Sbjct: 1591 DQYIFIHDALLEAV 1604
Score = 189 bits (481), Expect = 5e-48
Identities = 109/301 (36%), Positives = 168/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A ++ + +L + + E+ G EF+ L + + + + P NK KNR
Sbjct: 1609 TEVPARNLYAYIQKLTQIETGENVT--GMELEFKRLASSKA-HTSRFISANLPCNKFKNR 1665
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1666 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1719
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1720 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1778
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1779 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1837
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE QY+F Y A ++
Sbjct: 1838 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1894
Query: 516 I 516
+
Sbjct: 1895 L 1895
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 195 bits (495), Expect = 1e-49
Identities = 122/314 (38%), Positives = 178/314 (56%), Gaps = 23/314 (7%)
Query: 207 VYLRQPYYATRVNAADIENRVLELN---KKQESEDTAKAGFWEEFESLQK-QEVKNLHQR 262
V LR+ + T A+ +LEL ++ ++ D K F +E+ES+ Q+ H
Sbjct: 908 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLK--FSQEYESIDPGQQFTWEHSN 965
Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322
LE NK KNRY N++ +DHSRV+L + IPGSDY+NANYI YI
Sbjct: 966 LE----VNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYI 1015
Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382
A+QG L T DFW+M W++ S +VM T+ E+ R KC YWP G + +G VT
Sbjct: 1016 ATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLL 1074
Query: 383 GEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES 442
+ Y +RT + + + RE+ +Q+ +WPDHGVP P L+FL ++ + +
Sbjct: 1075 DTVELATYCVRTFALYKNGSSEK-REVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCN 1131
Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502
P AGP++VHCSAG+GRTG IVID ++E I + +DI + ++RAQR+ MVQTE
Sbjct: 1132 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTE 1188
Query: 503 AQYKFIYVAIAQFI 516
QY FI+ A+ + +
Sbjct: 1189 DQYIFIHDALLEAV 1202
Score = 189 bits (481), Expect = 5e-48
Identities = 109/301 (36%), Positives = 168/301 (55%), Gaps = 14/301 (4%)
Query: 216 TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNR 275
T V A ++ + +L + + E+ G EF+ L + + + + P NK KNR
Sbjct: 1207 TEVPARNLYAYIQKLTQIETGENVT--GMELEFKRLASSKA-HTSRFISANLPCNKFKNR 1263
Query: 276 YKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF 335
NI+P++ +RV LQ + GSDYINA++I K YIA+QG L T DF
Sbjct: 1264 LVNIMPYESTRVCLQPI-RGVEGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDF 1317
Query: 336 WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL 395
W+M W+ NS ++VM T+ E GR KC YWP R Y + V E++ +Y LR
Sbjct: 1318 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREF 1376
Query: 396 QVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSA 455
+V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E GPI VHCSA
Sbjct: 1377 KVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1435
Query: 456 GIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
G+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE QY+F Y A ++
Sbjct: 1436 GVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1492
Query: 516 I 516
+
Sbjct: 1493 L 1493
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 195 bits (495), Expect = 1e-49
Identities = 127/318 (39%), Positives = 175/318 (55%), Gaps = 21/318 (6%)
Query: 228 LELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRV 287
LE + S D K F EEF SL ++ + + EN+ KNRY NILP DHSRV
Sbjct: 120 LEEEIRIRSADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILPNDHSRV 176
Query: 288 ILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVI 347
IL D IP SDYINA+YI G E K +IA+QG + TVNDFW+M W++ S I
Sbjct: 177 ILSQLDG-IPCSDYINASYID----GYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSATI 230
Query: 348 VMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT--TEYKLRTLQVSPL--DNG 403
VM T E+ KC YWP+ G YG ++ C E +Y +R + P D
Sbjct: 231 VMLTNLKERKEEKCHQYWPDQGCW-TYG--NIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 287
Query: 404 DLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTI 463
R + + SWPD GVP P G+L FL ++ + + HAGPI+VHCSAG+GRTGT
Sbjct: 288 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKV--KTLNPVHAGPIVVHCSAGVGRTGTF 345
Query: 464 IVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL 523
IVID +M + + +D+ + + +R QR MVQT+ QY FIY A+ ++ +L
Sbjct: 346 IVIDAMMAMMHA---EQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTEL 402
Query: 524 EVLQSQKGQESEYGNITY 541
+V +K ++ +G T+
Sbjct: 403 DVSSLEKHLQTMHGTTTH 420
Score = 152 bits (383), Expect = 1e-36
Identities = 97/309 (31%), Positives = 154/309 (49%), Gaps = 18/309 (5%)
Query: 213 YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKG 272
Y T ++ + +E + ++ D K G EEF L + + R G P N
Sbjct: 397 YGDTELDVSSLEKHLQTMHGTTTHFD--KIGLEEEFRKLTNVRIMKENMRT-GNLPANMK 453
Query: 273 KNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATV 332
K R I+P+D +RVIL + +DYINA++I +IA+QG L TV
Sbjct: 454 KARVIQIIPYDFNRVILSMKRGQ-EYTDYINASFIDGY-----RQKDYFIATQGPLAHTV 507
Query: 333 NDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL 392
DFW+M W+ S IVM T E+ ++KC YWP G +G ++ + + +
Sbjct: 508 EDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG-SVTHGEITIEIKNDTLSEAISI 566
Query: 393 R----TLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP 448
R TL + +R + + + WP+ G+P+E G++ + + Q+Q+ P
Sbjct: 567 RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-QKQQQQTGNHP 625
Query: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508
I VHCSAG GRTGT I + ++E + +GL +D+ + ++ +R QR MVQT QY+F
Sbjct: 626 ITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFC 682
Query: 509 YVAIAQFIE 517
Y + FI+
Sbjct: 683 YKVVQDFID 691
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform
2 [Homo sapiens]
Length = 642
Score = 195 bits (495), Expect = 1e-49
Identities = 127/318 (39%), Positives = 175/318 (55%), Gaps = 21/318 (6%)
Query: 228 LELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRV 287
LE + S D K F EEF SL ++ + + EN+ KNRY NILP DHSRV
Sbjct: 62 LEEEIRIRSADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILPNDHSRV 118
Query: 288 ILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVI 347
IL D IP SDYINA+YI G E K +IA+QG + TVNDFW+M W++ S I
Sbjct: 119 ILSQLDG-IPCSDYINASYID----GYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSATI 172
Query: 348 VMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT--TEYKLRTLQVSPL--DNG 403
VM T E+ KC YWP+ G YG ++ C E +Y +R + P D
Sbjct: 173 VMLTNLKERKEEKCHQYWPDQGCW-TYG--NIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
Query: 404 DLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTI 463
R + + SWPD GVP P G+L FL ++ + + HAGPI+VHCSAG+GRTGT
Sbjct: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKV--KTLNPVHAGPIVVHCSAGVGRTGTF 287
Query: 464 IVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL 523
IVID +M + + +D+ + + +R QR MVQT+ QY FIY A+ ++ +L
Sbjct: 288 IVIDAMMAMMHA---EQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTEL 344
Query: 524 EVLQSQKGQESEYGNITY 541
+V +K ++ +G T+
Sbjct: 345 DVSSLEKHLQTMHGTTTH 362
Score = 152 bits (383), Expect = 1e-36
Identities = 97/309 (31%), Positives = 154/309 (49%), Gaps = 18/309 (5%)
Query: 213 YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKG 272
Y T ++ + +E + ++ D K G EEF L + + R G P N
Sbjct: 339 YGDTELDVSSLEKHLQTMHGTTTHFD--KIGLEEEFRKLTNVRIMKENMRT-GNLPANMK 395
Query: 273 KNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATV 332
K R I+P+D +RVIL + +DYINA++I +IA+QG L TV
Sbjct: 396 KARVIQIIPYDFNRVILSMKRGQ-EYTDYINASFIDGY-----RQKDYFIATQGPLAHTV 449
Query: 333 NDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL 392
DFW+M W+ S IVM T E+ ++KC YWP G +G ++ + + +
Sbjct: 450 EDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG-SVTHGEITIEIKNDTLSEAISI 508
Query: 393 R----TLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP 448
R TL + +R + + + WP+ G+P+E G++ + + Q+Q+ P
Sbjct: 509 RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-QKQQQQTGNHP 567
Query: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508
I VHCSAG GRTGT I + ++E + +GL +D+ + ++ +R QR MVQT QY+F
Sbjct: 568 ITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFC 624
Query: 509 YVAIAQFIE 517
Y + FI+
Sbjct: 625 YKVVQDFID 633
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 191 bits (485), Expect = 2e-48
Identities = 112/272 (41%), Positives = 155/272 (56%), Gaps = 17/272 (6%)
Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
GF EE+ES + + ++ EN+ KNRY NI+ +DHSRV LQ + + SDYI
Sbjct: 899 GFKEEYESFFEGQSAPWDS---AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDT-NSDYI 954
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
N NYI YIA+QG ++ T+ DFW+M W EN+ I+M T VE GR KC
Sbjct: 955 NGNYIDGY-----HRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC 1009
Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422
YWP+ Y VT EY +RT V + IREI + + WPDHGV
Sbjct: 1010 KYWPD--DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHE-IREIRQFHFTGWPDHGV 1066
Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482
P G+L F+ Q+ + +S P AGP++VHCSAG GRTG IVID++++ +G+ +
Sbjct: 1067 PYHATGLLGFVRQV--KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---V 1121
Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
DI ++ +R++R MVQTE QY FI+ AI +
Sbjct: 1122 DIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153
Score = 88.6 bits (218), Expect = 1e-17
Identities = 95/401 (23%), Positives = 158/401 (39%), Gaps = 52/401 (12%)
Query: 145 FVLSVLSDQP-KAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEH---------- 193
FV V S P AGP + V C G G D + D+ E
Sbjct: 1076 FVRQVKSKSPPSAGP--------LVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1127
Query: 194 ----FKKTGIEEASGAFVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAG 243
++ + + +V++ T V A+ + + ++NK ++++
Sbjct: 1128 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1187
Query: 244 FWEEFESLQK-QEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
EEF +L + P N KNR +ILP D L D
Sbjct: 1188 --EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE------- 1238
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
++NYI L+ + +I +Q L TV DFW++ + +VM +V+ + C
Sbjct: 1239 SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVM-LNDVDPAQ-LCP 1296
Query: 363 PYWPEVGMQRAYGPYSVTNCG---EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPD 419
YWPE G+ R +GP V E D R + +G R + +Q+L WP
Sbjct: 1297 QYWPENGVHR-HGPIQVEFVSADLEEDIISRIFRIYNAARPQDG--YRMVQQFQFLGWPM 1353
Query: 420 H-GVPSEPGGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477
+ P L + Q+++ QE G +VHC G GR+GT I ++ E + +
Sbjct: 1354 YRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR 1413
Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518
+D+ ++ +R + MV QYKF Y +++ +
Sbjct: 1414 ---TVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 191 bits (485), Expect = 2e-48
Identities = 112/272 (41%), Positives = 155/272 (56%), Gaps = 17/272 (6%)
Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
GF EE+ES + + ++ EN+ KNRY NI+ +DHSRV LQ + + SDYI
Sbjct: 912 GFKEEYESFFEGQSAPWDS---AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDT-NSDYI 967
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
N NYI YIA+QG ++ T+ DFW+M W EN+ I+M T VE GR KC
Sbjct: 968 NGNYIDGY-----HRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC 1022
Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422
YWP+ Y VT EY +RT V + IREI + + WPDHGV
Sbjct: 1023 KYWPD--DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHE-IREIRQFHFTGWPDHGV 1079
Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482
P G+L F+ Q+ + +S P AGP++VHCSAG GRTG IVID++++ +G+ +
Sbjct: 1080 PYHATGLLGFVRQV--KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---V 1134
Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
DI ++ +R++R MVQTE QY FI+ AI +
Sbjct: 1135 DIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166
Score = 88.6 bits (218), Expect = 1e-17
Identities = 95/401 (23%), Positives = 158/401 (39%), Gaps = 52/401 (12%)
Query: 145 FVLSVLSDQP-KAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEH---------- 193
FV V S P AGP + V C G G D + D+ E
Sbjct: 1089 FVRQVKSKSPPSAGP--------LVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140
Query: 194 ----FKKTGIEEASGAFVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAG 243
++ + + +V++ T V A+ + + ++NK ++++
Sbjct: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200
Query: 244 FWEEFESLQK-QEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
EEF +L + P N KNR +ILP D L D
Sbjct: 1201 --EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE------- 1251
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
++NYI L+ + +I +Q L TV DFW++ + +VM +V+ + C
Sbjct: 1252 SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVM-LNDVDPAQ-LCP 1309
Query: 363 PYWPEVGMQRAYGPYSVTNCG---EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPD 419
YWPE G+ R +GP V E D R + +G R + +Q+L WP
Sbjct: 1310 QYWPENGVHR-HGPIQVEFVSADLEEDIISRIFRIYNAARPQDG--YRMVQQFQFLGWPM 1366
Query: 420 H-GVPSEPGGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477
+ P L + Q+++ QE G +VHC G GR+GT I ++ E + +
Sbjct: 1367 YRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR 1426
Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518
+D+ ++ +R + MV QYKF Y +++ +
Sbjct: 1427 ---TVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 191 bits (484), Expect = 2e-48
Identities = 103/258 (39%), Positives = 143/258 (55%), Gaps = 11/258 (4%)
Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDEN-AKTYIASQG 326
PEN+GKNRY NILP+D +RV L D + P SDYINA+YI P N + YI +QG
Sbjct: 1943 PENRGKNRYNNILPYDATRVKLSNVDDD-PCSDYINASYI------PGNNFRREYIVTQG 1995
Query: 327 CLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD 386
L T +DFW+M W++N IVM T+ VEKGR KC YWP YG + E
Sbjct: 1996 PLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESV 2055
Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA 446
E+ +R ++ + D R I H+ Y WPDHGVP ++ F+ + P A
Sbjct: 2056 LPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA 2115
Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK 506
GP +VHCSAG+GRTGT I +D +++ + +K +DI + +R R MVQTE QY
Sbjct: 2116 GPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQYV 2172
Query: 507 FIYVAIAQFIETTKKKLE 524
+++ + + K + E
Sbjct: 2173 YLHQCVRDVLRARKLRSE 2190
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 191 bits (484), Expect = 2e-48
Identities = 103/258 (39%), Positives = 143/258 (55%), Gaps = 11/258 (4%)
Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDEN-AKTYIASQG 326
PEN+GKNRY NILP+D +RV L D + P SDYINA+YI P N + YI +QG
Sbjct: 1725 PENRGKNRYNNILPYDATRVKLSNVDDD-PCSDYINASYI------PGNNFRREYIVTQG 1777
Query: 327 CLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD 386
L T +DFW+M W++N IVM T+ VEKGR KC YWP YG + E
Sbjct: 1778 PLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESV 1837
Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA 446
E+ +R ++ + D R I H+ Y WPDHGVP ++ F+ + P A
Sbjct: 1838 LPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA 1897
Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK 506
GP +VHCSAG+GRTGT I +D +++ + +K +DI + +R R MVQTE QY
Sbjct: 1898 GPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQYV 1954
Query: 507 FIYVAIAQFIETTKKKLE 524
+++ + + K + E
Sbjct: 1955 YLHQCVRDVLRARKLRSE 1972
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 191 bits (484), Expect = 2e-48
Identities = 124/305 (40%), Positives = 173/305 (56%), Gaps = 30/305 (9%)
Query: 240 AKAGFWEEFESLQK--QEVKNLHQRL-----EGQRPENKGKNRYKNILPFDHSRVIL-QG 291
A +GF EEFE+L++ QEV++ L P+NK KNRY NI+ +DHSRV L Q
Sbjct: 1713 ASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 1772
Query: 292 RDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTT 351
+ + +DYINANY+ K YIA+QG L++T DFW+M W+ N VIVM T
Sbjct: 1773 AEKDGKLTDYINANYVDGY-----NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT 1827
Query: 352 REVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLR--TLQVSPLDNGDLI--- 406
VEKGR KC YWP G + YG + VT Y +R TL+ + + G
Sbjct: 1828 NLVEKGRRKCDQYWPADGSEE-YGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRP 1886
Query: 407 --REIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTI 463
R + Y Y WPD GVP VL+F + + + HA GP++VHCSAG+GRTGT
Sbjct: 1887 SGRVVTQYHYTQWPDMGVPEYSLPVLTF---VRKAAYAKRHAVGPVVVHCSAGVGRTGTY 1943
Query: 464 IVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL 523
IV+D +++ I +G ++I ++ +R+QR+ +VQTE QY FI+ + + I K+
Sbjct: 1944 IVLDSMLQQIQHEG---TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI--LSKET 1998
Query: 524 EVLQS 528
EVL S
Sbjct: 1999 EVLDS 2003
Score = 95.1 bits (235), Expect = 2e-19
Identities = 95/404 (23%), Positives = 167/404 (41%), Gaps = 45/404 (11%)
Query: 144 DFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEAS 203
++ L VL+ KA V + V C G VG T+ L +++ + G
Sbjct: 1906 EYSLPVLTFVRKAAYAKRHAVGPVVVHCSAG---VGRTGTYIVLDSMLQQIQHEGTVNIF 1962
Query: 204 GAFVYLRQP---YYATRVNAADIENRVLE--LNKKQESEDT---------------AKAG 243
G ++R T I + ++E L+K+ E D+ K
Sbjct: 1963 GFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTK 2022
Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303
++F+ L + ++ + N+ KNR +I+P + SRV + G+DYIN
Sbjct: 2023 LEKQFQLLSQSNIQQSDYSA-ALKQCNREKNRTSSIIPVERSRVGISSLSGE--GTDYIN 2079
Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363
A+YI + +I +Q L T+ DFW+M W N++++VM ++ V
Sbjct: 2080 ASYIMGYY-----QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV- 2133
Query: 364 YWPEVGMQRAYGPYSVTNCGEHD---TTEYKLRTLQ-VSPLDNGDLIREIWHYQYLSWPD 419
YWP + VT E + E KL + D + E+ H+Q WP+
Sbjct: 2134 YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN 2193
Query: 420 HGVP-SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478
P S+ ++S + ++E+ GP+IVH G GT + LM + +
Sbjct: 2194 PDSPISKTFELISVI-----KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKEN- 2247
Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKK 522
+D+ + +M+ R G+ QY+F+Y I + T +++
Sbjct: 2248 --SVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEE 2289
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 190 bits (483), Expect = 3e-48
Identities = 119/300 (39%), Positives = 166/300 (55%), Gaps = 28/300 (9%)
Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ---GRDSNIPGS 299
GF E+FE +Q+ PENK KNRY NIL +DHSRV L+ G+DS S
Sbjct: 847 GFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSK--HS 904
Query: 300 DYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN 359
DYINANY+ AK YIA+QG L++T DFW+M W++N+ +IVM T VEKGR
Sbjct: 905 DYINANYVDGY-----NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRR 959
Query: 360 KCVPYWPEVGMQRAYGPYSVTNCGE-----HDTTEYKLRTLQVSPLDNGD-----LIREI 409
KC YWP + YG VT + + +R +V G+ R +
Sbjct: 960 KCDQYWPTENSEE-YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVV 1018
Query: 410 WHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469
Y Y WPD GVP VL+F+ + + + +P GP++VHCSAG+GRTGT IVID +
Sbjct: 1019 IQYHYTQWPDMGVPEYALPVLTFVRRSSAAR--MPETGPVLVHCSAGVGRTGTYIVIDSM 1076
Query: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ 529
++ I K +++ ++ +R QR+ +VQTE QY FI+ A+ + I K+ EV +Q
Sbjct: 1077 LQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI--LGKETEVSSNQ 1131
Score = 93.2 bits (230), Expect = 6e-19
Identities = 69/258 (26%), Positives = 115/258 (44%), Gaps = 20/258 (7%)
Query: 266 QRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQ 325
Q+ NK KNR +++P + +RV L + G+DYINA+YI + +I +Q
Sbjct: 1171 QKECNKEKNRNSSVVPSERARVGLAPLPG-MKGTDYINASYIMGYY-----RSNEFIITQ 1224
Query: 326 GCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEH 385
L T DFW+M W N+++IVM ++ V YWP ++VT +
Sbjct: 1225 HPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESMNCEAFTVTLISKD 1283
Query: 386 ----DTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ-RQ 440
E + + D + E+ H+Q WP+ P + S + IN ++
Sbjct: 1284 RLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP-----ISSTFELINVIKE 1338
Query: 441 ESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQ 500
E+L GP IVH G G + + L + + + +D+ + +M+ R G+
Sbjct: 1339 EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPGVFT 1395
Query: 501 TEAQYKFIYVAIAQFIET 518
QY+FIY A+ + T
Sbjct: 1396 DIEQYQFIYKAMLSLVST 1413
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 190 bits (482), Expect = 4e-48
Identities = 111/272 (40%), Positives = 157/272 (57%), Gaps = 18/272 (6%)
Query: 244 FWEEFESLQK-QEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
F +E+ES+ Q+ + LE NK KNRY N++ +DHSRVIL D +PGSDYI
Sbjct: 1352 FSQEYESIDPGQQFTWENSNLE----VNKPKNRYANVIAYDHSRVILTSIDG-VPGSDYI 1406
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
NANYI YIA+QG L T+ DFW+M W++ + +VM TR EK R KC
Sbjct: 1407 NANYIDGY-----RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD 1461
Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422
YWP G + G VT + Y +RT + + + RE+ +Q+++WPDHGV
Sbjct: 1462 QYWPARGTETC-GLIQVTLLDTVELATYTVRTFALHKSGSSEK-RELRQFQFMAWPDHGV 1519
Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482
P P +L+FL ++ AGP++VHCSAG+GRTG IVID ++E + + +
Sbjct: 1520 PEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTV 1574
Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
DI + +R+QR+ MVQTE QY FI+ A+ +
Sbjct: 1575 DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606
Score = 181 bits (458), Expect = 2e-45
Identities = 116/377 (30%), Positives = 186/377 (49%), Gaps = 34/377 (9%)
Query: 160 SPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--------------EASGA 205
+PL + V C G G D++ + ++H K I +
Sbjct: 1537 NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ 1596
Query: 206 FVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259
+V++ + T V A ++ + +L + E EF+ L + +
Sbjct: 1597 YVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMEL--EFKLLASSKA-HT 1653
Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319
+ + P NK KNR NI+P++ +RV LQ + GSDYINA+++ K
Sbjct: 1654 SRFISANLPCNKFKNRLVNIMPYELTRVCLQPI-RGVEGSDYINASFLDGY-----RQQK 1707
Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSV 379
YIA+QG L + DFW+M W+ NS +IVM T+ E GR KC YWP R Y + V
Sbjct: 1708 AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR-YQYFVV 1766
Query: 380 TNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR 439
E++ +Y LR +V+ +G R I +Q+ WP+ GVP G + F+ Q+++
Sbjct: 1767 DPMAEYNMPQYILREFKVTDARDGQS-RTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKT 1825
Query: 440 QESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV 499
+E GPI VHCSAG+GRTG I + +++E + +G+ +D+ +T++ +R QR MV
Sbjct: 1826 KEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMV 1882
Query: 500 QTEAQYKFIYVAIAQFI 516
QTE QY+ Y A +++
Sbjct: 1883 QTEDQYQLCYRAALEYL 1899
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 190 bits (482), Expect = 4e-48
Identities = 111/272 (40%), Positives = 157/272 (57%), Gaps = 18/272 (6%)
Query: 244 FWEEFESLQK-QEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302
F +E+ES+ Q+ + LE NK KNRY N++ +DHSRVIL D +PGSDYI
Sbjct: 1343 FSQEYESIDPGQQFTWENSNLE----VNKPKNRYANVIAYDHSRVILTSIDG-VPGSDYI 1397
Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362
NANYI YIA+QG L T+ DFW+M W++ + +VM TR EK R KC
Sbjct: 1398 NANYIDGY-----RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD 1452
Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422
YWP G + G VT + Y +RT + + + RE+ +Q+++WPDHGV
Sbjct: 1453 QYWPARGTETC-GLIQVTLLDTVELATYTVRTFALHKSGSSEK-RELRQFQFMAWPDHGV 1510
Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482
P P +L+FL ++ AGP++VHCSAG+GRTG IVID ++E + + +
Sbjct: 1511 PEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTV 1565
Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
DI + +R+QR+ MVQTE QY FI+ A+ +
Sbjct: 1566 DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
Score = 181 bits (458), Expect = 2e-45
Identities = 116/377 (30%), Positives = 186/377 (49%), Gaps = 34/377 (9%)
Query: 160 SPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--------------EASGA 205
+PL + V C G G D++ + ++H K I +
Sbjct: 1528 NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ 1587
Query: 206 FVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259
+V++ + T V A ++ + +L + E EF+ L + +
Sbjct: 1588 YVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMEL--EFKLLASSKA-HT 1644
Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319
+ + P NK KNR NI+P++ +RV LQ + GSDYINA+++ K
Sbjct: 1645 SRFISANLPCNKFKNRLVNIMPYELTRVCLQPI-RGVEGSDYINASFLDGY-----RQQK 1698
Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSV 379
YIA+QG L + DFW+M W+ NS +IVM T+ E GR KC YWP R Y + V
Sbjct: 1699 AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR-YQYFVV 1757
Query: 380 TNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR 439
E++ +Y LR +V+ +G R I +Q+ WP+ GVP G + F+ Q+++
Sbjct: 1758 DPMAEYNMPQYILREFKVTDARDGQS-RTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKT 1816
Query: 440 QESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV 499
+E GPI VHCSAG+GRTG I + +++E + +G+ +D+ +T++ +R QR MV
Sbjct: 1817 KEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMV 1873
Query: 500 QTEAQYKFIYVAIAQFI 516
QTE QY+ Y A +++
Sbjct: 1874 QTEDQYQLCYRAALEYL 1890
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 190 bits (482), Expect = 4e-48
Identities = 120/314 (38%), Positives = 171/314 (54%), Gaps = 20/314 (6%)
Query: 229 ELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVI 288
E+N++ ++ F EEF +L ++ + + ENK KNRY NILP+DHSRV
Sbjct: 220 EINRRMADDNKL---FREEFNALPACPIQATCEA--ASKEENKEKNRYVNILPYDHSRVH 274
Query: 289 LQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIV 348
L + +P SDYINA++I G E K +IA+QG E TVNDFW+M W++N+ IV
Sbjct: 275 LTPVEG-VPDSDYINASFIN----GYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIV 328
Query: 349 MTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL---QVSPLDNGDL 405
M T E+ KC YWP+ G YG V+ +Y +R QV + N
Sbjct: 329 MVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387
Query: 406 IREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465
R I + + SWPD GVP P G+L FL ++ +AG I+VHCSAG+GRTGT +V
Sbjct: 388 QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVV 445
Query: 466 IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV 525
ID +++ + T + +D+ + +RAQR MVQT+ QY FIY A+ + +LEV
Sbjct: 446 IDAMLDMMHT---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEV 502
Query: 526 LQSQKGQESEYGNI 539
+ + Y I
Sbjct: 503 TSLETHLQKIYNKI 516
Score = 172 bits (435), Expect = 1e-42
Identities = 114/372 (30%), Positives = 186/372 (50%), Gaps = 37/372 (9%)
Query: 167 IKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--------------EASGAFVYLRQP 212
I V C G G D++ D++ +K + + +V++ Q
Sbjct: 429 IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQA 488
Query: 213 ------YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQ 266
Y T + +E + ++ K T+ G EEF+ L +++N R G
Sbjct: 489 LLEHYLYGDTELEVTSLETHLQKIYNKIPG--TSNNGLEEEFKKLTSIKIQNDKMRT-GN 545
Query: 267 RPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQG 326
P N KNR I+P++ +RVI+ + +DY+NA++I +YIASQG
Sbjct: 546 LPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIASQG 599
Query: 327 CLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD 386
L T+ DFW+M W+ S IVM T E+G+ KC YWP G+ +YG +V E +
Sbjct: 600 PLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVELKKEEE 658
Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-NQRQESLPH 445
Y +R L V+ + R+I + + WP+ G+PS+ G++S + + Q+Q+S H
Sbjct: 659 CESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH 717
Query: 446 AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQY 505
PI VHCSAG GRTGT + ++E + +G+ +D+ +T++ +R QR MVQT QY
Sbjct: 718 --PITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQY 772
Query: 506 KFIYVAIAQFIE 517
+F Y + ++I+
Sbjct: 773 EFCYKVVQEYID 784
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 190 bits (482), Expect = 4e-48
Identities = 120/314 (38%), Positives = 171/314 (54%), Gaps = 20/314 (6%)
Query: 229 ELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVI 288
E+N++ ++ F EEF +L ++ + + ENK KNRY NILP+DHSRV
Sbjct: 229 EINRRMADDNKL---FREEFNALPACPIQATCEA--ASKEENKEKNRYVNILPYDHSRVH 283
Query: 289 LQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIV 348
L + +P SDYINA++I G E K +IA+QG E TVNDFW+M W++N+ IV
Sbjct: 284 LTPVEG-VPDSDYINASFIN----GYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIV 337
Query: 349 MTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL---QVSPLDNGDL 405
M T E+ KC YWP+ G YG V+ +Y +R QV + N
Sbjct: 338 MVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 396
Query: 406 IREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465
R I + + SWPD GVP P G+L FL ++ +AG I+VHCSAG+GRTGT +V
Sbjct: 397 QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVV 454
Query: 466 IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV 525
ID +++ + T + +D+ + +RAQR MVQT+ QY FIY A+ + +LEV
Sbjct: 455 IDAMLDMMHT---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEV 511
Query: 526 LQSQKGQESEYGNI 539
+ + Y I
Sbjct: 512 TSLETHLQKIYNKI 525
Score = 172 bits (435), Expect = 1e-42
Identities = 114/372 (30%), Positives = 186/372 (50%), Gaps = 37/372 (9%)
Query: 167 IKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--------------EASGAFVYLRQP 212
I V C G G D++ D++ +K + + +V++ Q
Sbjct: 438 IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQA 497
Query: 213 ------YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQ 266
Y T + +E + ++ K T+ G EEF+ L +++N R G
Sbjct: 498 LLEHYLYGDTELEVTSLETHLQKIYNKIPG--TSNNGLEEEFKKLTSIKIQNDKMRT-GN 554
Query: 267 RPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQG 326
P N KNR I+P++ +RVI+ + +DY+NA++I +YIASQG
Sbjct: 555 LPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIASQG 608
Query: 327 CLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD 386
L T+ DFW+M W+ S IVM T E+G+ KC YWP G+ +YG +V E +
Sbjct: 609 PLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVELKKEEE 667
Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-NQRQESLPH 445
Y +R L V+ + R+I + + WP+ G+PS+ G++S + + Q+Q+S H
Sbjct: 668 CESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH 726
Query: 446 AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQY 505
PI VHCSAG GRTGT + ++E + +G+ +D+ +T++ +R QR MVQT QY
Sbjct: 727 --PITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQY 781
Query: 506 KFIYVAIAQFIE 517
+F Y + ++I+
Sbjct: 782 EFCYKVVQEYID 793
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 190 bits (482), Expect = 4e-48
Identities = 120/314 (38%), Positives = 171/314 (54%), Gaps = 20/314 (6%)
Query: 229 ELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVI 288
E+N++ ++ F EEF +L ++ + + ENK KNRY NILP+DHSRV
Sbjct: 220 EINRRMADDNKL---FREEFNALPACPIQATCEA--ASKEENKEKNRYVNILPYDHSRVH 274
Query: 289 LQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIV 348
L + +P SDYINA++I G E K +IA+QG E TVNDFW+M W++N+ IV
Sbjct: 275 LTPVEG-VPDSDYINASFIN----GYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIV 328
Query: 349 MTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL---QVSPLDNGDL 405
M T E+ KC YWP+ G YG V+ +Y +R QV + N
Sbjct: 329 MVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387
Query: 406 IREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465
R I + + SWPD GVP P G+L FL ++ +AG I+VHCSAG+GRTGT +V
Sbjct: 388 QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVV 445
Query: 466 IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV 525
ID +++ + T + +D+ + +RAQR MVQT+ QY FIY A+ + +LEV
Sbjct: 446 IDAMLDMMHT---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEV 502
Query: 526 LQSQKGQESEYGNI 539
+ + Y I
Sbjct: 503 TSLETHLQKIYNKI 516
Score = 172 bits (435), Expect = 1e-42
Identities = 114/372 (30%), Positives = 186/372 (50%), Gaps = 37/372 (9%)
Query: 167 IKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--------------EASGAFVYLRQP 212
I V C G G D++ D++ +K + + +V++ Q
Sbjct: 429 IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQA 488
Query: 213 ------YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQ 266
Y T + +E + ++ K T+ G EEF+ L +++N R G
Sbjct: 489 LLEHYLYGDTELEVTSLETHLQKIYNKIPG--TSNNGLEEEFKKLTSIKIQNDKMRT-GN 545
Query: 267 RPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQG 326
P N KNR I+P++ +RVI+ + +DY+NA++I +YIASQG
Sbjct: 546 LPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIASQG 599
Query: 327 CLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD 386
L T+ DFW+M W+ S IVM T E+G+ KC YWP G+ +YG +V E +
Sbjct: 600 PLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVELKKEEE 658
Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-NQRQESLPH 445
Y +R L V+ + R+I + + WP+ G+PS+ G++S + + Q+Q+S H
Sbjct: 659 CESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH 717
Query: 446 AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQY 505
PI VHCSAG GRTGT + ++E + +G+ +D+ +T++ +R QR MVQT QY
Sbjct: 718 --PITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQY 772
Query: 506 KFIYVAIAQFIE 517
+F Y + ++I+
Sbjct: 773 EFCYKVVQEYID 784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,796,593
Number of Sequences: 37866
Number of extensions: 1044591
Number of successful extensions: 4965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 3898
Number of HSP's gapped (non-prelim): 555
length of query: 595
length of database: 18,247,518
effective HSP length: 108
effective length of query: 487
effective length of database: 14,157,990
effective search space: 6894941130
effective search space used: 6894941130
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.