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Search of human proteins with 11225256
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11225256 uncoupling protein 1 [Homo sapiens]
(307 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11225256 uncoupling protein 1 [Homo sapiens] 610 e-175
gi|13259541 uncoupling protein 2 [Homo sapiens] 354 5e-98
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 353 1e-97
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 310 1e-84
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 172 3e-43
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 172 4e-43
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 172 4e-43
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 171 6e-43
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 170 2e-42
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 162 3e-40
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 129 2e-30
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 102 3e-22
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 99 4e-21
gi|41462412 solute carrier family 25, member 35 [Homo sapiens] 98 1e-20
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 96 3e-20
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 92 6e-19
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 90 2e-18
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 89 5e-18
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 87 2e-17
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 87 2e-17
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 87 2e-17
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 87 2e-17
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 87 2e-17
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 86 3e-17
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 85 7e-17
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 85 7e-17
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 85 7e-17
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 85 7e-17
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 85 7e-17
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 85 7e-17
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 610 bits (1573), Expect = e-175
Identities = 307/307 (100%), Positives = 307/307 (100%)
Query: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLG 60
MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLG
Sbjct: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLG 60
Query: 61 TITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAG 120
TITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAG
Sbjct: 61 TITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAG 120
Query: 121 LTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPN 180
LTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPN
Sbjct: 121 LTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPN 180
Query: 181 LMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF 240
LMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF
Sbjct: 181 LMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF 240
Query: 241 INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSR 300
INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSR
Sbjct: 241 INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSR 300
Query: 301 QTMDCAT 307
QTMDCAT
Sbjct: 301 QTMDCAT 307
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 354 bits (909), Expect = 5e-98
Identities = 178/300 (59%), Positives = 226/300 (75%), Gaps = 6/300 (2%)
Query: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECP----TSSVIRYK 56
M G A+DV PT V+ AG AAC+AD+ITFPLDTAKVRLQ+QGE ++ +Y+
Sbjct: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60
Query: 57 GVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSK 116
GV+GTI +V+TEG LY+GL AGLQRQ+S AS+RIGLYD+V++F T G E A S+GS+
Sbjct: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA-SIGSR 119
Query: 117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKG 176
+LAG TTG +AV + QPT+VVKVR QAQ+ G + RY T NAY+ IA EG GLWKG
Sbjct: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR-RYQSTVNAYKTIAREEGFRGLWKG 178
Query: 177 TTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVV 236
T+PN+ R+ I+NC ELVTYDL+K+A +K N++ DD+PCH SA AGFC T ++SPVDVV
Sbjct: 179 TSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVV 238
Query: 237 KTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKREL 296
KTR++NS GQY S +CA+ + EGP AF+KG +PSFLRLGSWNV+MFV +EQLKR L
Sbjct: 239 KTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/206 (26%), Positives = 81/206 (39%), Gaps = 10/206 (4%)
Query: 108 ETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHG-----IKPRYTGTYNAYR 162
+ P+ K L T +A I P + KVRLQ Q G +Y G
Sbjct: 8 DVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTIL 67
Query: 163 IIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIA 222
+ TEG L+ G L R + + YD +K+ + K + A + L++
Sbjct: 68 TMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-IGSRLLAGSTT 126
Query: 223 GFCATAMSSPVDVVKTRFINSPPG----QYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRL 278
G A A++ P DVVK RF +Y+S N + EG +KG P+ R
Sbjct: 127 GALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARN 186
Query: 279 GSWNVIMFVCFEQLKRELSKSRQTMD 304
N V ++ +K L K+ D
Sbjct: 187 AIVNCAELVTYDLIKDALLKANLMTD 212
Score = 61.6 bits (148), Expect = 8e-10
Identities = 44/199 (22%), Positives = 74/199 (37%), Gaps = 7/199 (3%)
Query: 5 TASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITA 64
T H ++G +L + LA + P D KVR Q Q RY+ +
Sbjct: 108 TKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR--RYQSTVNAYKT 165
Query: 65 VVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG 124
+ + EG L+ G + R + YD +++ L L + G
Sbjct: 166 IAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAG 225
Query: 125 GVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRS 184
I P +VVK R +++ +Y+ + + EG +KG P+ +R
Sbjct: 226 FCTTVIASPVDVVKTR-----YMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRL 280
Query: 185 VIINCTELVTYDLMKEAFV 203
N VTY+ +K A +
Sbjct: 281 GSWNVVMFVTYEQLKRALM 299
Score = 28.9 bits (63), Expect = 6.0
Identities = 24/107 (22%), Positives = 42/107 (39%), Gaps = 14/107 (13%)
Query: 209 ADDVP----CHLVSALIAGFCATAMSSPVDVVKTRFI----------NSPPGQYKSVPNC 254
A DVP + A A A ++ P+D K R + QY+ V
Sbjct: 6 ATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGT 65
Query: 255 AMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQ 301
+ + EGP + + GLV R S+ + ++ +K+ +K +
Sbjct: 66 ILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSE 112
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 353 bits (906), Expect = 1e-97
Identities = 178/303 (58%), Positives = 225/303 (74%), Gaps = 5/303 (1%)
Query: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE---CPTSSVIRYKG 57
M GL SDV PT+ V+ AG AAC AD++TFPLDTAKVRLQ+QGE T+ +++Y+G
Sbjct: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
Query: 58 VLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKI 117
VLGTI +V+TEG Y+GL AGLQRQ+S AS+RIGLYD+V++ T SL ++I
Sbjct: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
Query: 118 LAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATTEGLTGLWK 175
LAG TTG +AV QPT+VVKVR QA HL + +Y+GT +AYR IA EG+ GLWK
Sbjct: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
Query: 176 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 235
GT PN+MR+ I+NC E+VTYD++KE + ++L D+ PCH VSA AGFCAT ++SPVDV
Sbjct: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
Query: 236 VKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRE 295
VKTR++NSPPGQY S +C +K+ EGPTAF+KG PSFLRLGSWNV+MFV +EQLKR
Sbjct: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA 300
Query: 296 LSK 298
L K
Sbjct: 301 LMK 303
Score = 59.3 bits (142), Expect = 4e-09
Identities = 45/200 (22%), Positives = 79/200 (39%), Gaps = 6/200 (3%)
Query: 12 TLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGEC-PTSSVIRYKGVLGTITAVVKTEG 70
+L ++ + +A P D KVR Q P+ S +Y G + + + EG
Sbjct: 115 SLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEG 174
Query: 71 RMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFI 130
L+ G + R + YD ++E L + ++ G A +
Sbjct: 175 VRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVV 234
Query: 131 GQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCT 190
P +VVK R +++ +Y + + EG T +KG TP+ +R N
Sbjct: 235 ASPVDVVKTR-----YMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVV 289
Query: 191 ELVTYDLMKEAFVKNNILAD 210
VTY+ +K A +K +L +
Sbjct: 290 MFVTYEQLKRALMKVQMLRE 309
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 310 bits (794), Expect = 1e-84
Identities = 157/275 (57%), Positives = 202/275 (73%), Gaps = 5/275 (1%)
Query: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE---CPTSSVIRYKG 57
M GL SDV PT+ V+ AG AAC AD++TFPLDTAKVRLQ+QGE T+ +++Y+G
Sbjct: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
Query: 58 VLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKI 117
VLGTI +V+TEG Y+GL AGLQRQ+S AS+RIGLYD+V++ T SL ++I
Sbjct: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
Query: 118 LAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATTEGLTGLWK 175
LAG TTG +AV QPT+VVKVR QA HL + +Y+GT +AYR IA EG+ GLWK
Sbjct: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
Query: 176 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 235
GT PN+MR+ I+NC E+VTYD++KE + ++L D+ PCH VSA AGFCAT ++SPVDV
Sbjct: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
Query: 236 VKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKG 270
VKTR++NSPPGQY S +C +K+ EGPTAF+KG
Sbjct: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/200 (23%), Positives = 77/200 (38%), Gaps = 11/200 (5%)
Query: 108 ETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP----RYTGTYNAYRI 163
+ P++ K L T A + P + KVRLQ Q ++ +Y G
Sbjct: 8 DVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILT 67
Query: 164 IATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAG 223
+ TEG + G L R + + YD +K+ + + +++ G
Sbjct: 68 MVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTG 127
Query: 224 FCATAMSSPVDVVKTRF---INSPPGQ----YKSVPNCAMKVFTNEGPTAFFKGLVPSFL 276
A + P DVVK RF I+ P + Y + + EG +KG +P+ +
Sbjct: 128 AMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIM 187
Query: 277 RLGSWNVIMFVCFEQLKREL 296
R N V ++ LK +L
Sbjct: 188 RNAIVNCAEVVTYDILKEKL 207
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 172 bits (436), Expect = 3e-43
Identities = 97/283 (34%), Positives = 155/283 (54%), Gaps = 16/283 (5%)
Query: 21 GIAACLADVITFPLDTAKVRLQVQGECPTSSV--IRYKGVLGTITAVVKTEGRMKLYSGL 78
G+A+ A+ TFP+D K RLQ+QG+ + IRY+G+L + + + EG LYSG+
Sbjct: 13 GLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGI 72
Query: 79 PAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVK 138
+ RQ S +++IG Y +++ E +L ++ G+ +G ++ I PT+V+K
Sbjct: 73 APAMLRQASYGTIKIGTYQSLKRLFIERPEDE-TLPINVICGILSGVISSTIANPTDVLK 131
Query: 139 VRLQAQSH-LHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDL 197
+R+QAQS+ + G G + I EG GLWKG + R+ I+ EL YD+
Sbjct: 132 IRMQAQSNTIQG------GMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDI 185
Query: 198 MKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPP------GQYKSV 251
K+ + + ++ D V H +S+ G S+PVDVV+TR +N Y
Sbjct: 186 TKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGYTGT 245
Query: 252 PNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+C ++ + NEG A +KG P++LRLG WN+I FV +EQLK+
Sbjct: 246 LDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288
Score = 66.2 bits (160), Expect = 3e-11
Identities = 49/190 (25%), Positives = 83/190 (43%), Gaps = 7/190 (3%)
Query: 12 TLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGR 71
TL + + ++ ++ I P D K+R+Q Q S+ I+ G++G + + EG
Sbjct: 105 TLPINVICGILSGVISSTIANPTDVLKIRMQAQ-----SNTIQ-GGMIGNFMNIYQQEGT 158
Query: 72 MKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIG 131
L+ G+ QR + + +YD ++ L ++ + L+ T G
Sbjct: 159 RGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALAS 218
Query: 132 QPTEVVKVRLQAQSHLH-GIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCT 190
P +VV+ R+ Q L G YTGT + EG L+KG PN +R N
Sbjct: 219 NPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNII 278
Query: 191 ELVTYDLMKE 200
VTY+ +K+
Sbjct: 279 FFVTYEQLKK 288
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 172 bits (435), Expect = 4e-43
Identities = 97/282 (34%), Positives = 157/282 (55%), Gaps = 15/282 (5%)
Query: 21 GIAACLADVITFPLDTAKVRLQVQGECPTSSV--IRYKGVLGTITAVVKTEGRMKLYSGL 78
G+A+ +A+ TFP+D K RLQVQG+ + I+Y+G+ + + K EG + LYSG+
Sbjct: 48 GLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGI 107
Query: 79 PAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVK 138
L RQ S +++IG+Y +++ E L ++ G+ +G ++ I PT+V+K
Sbjct: 108 APALLRQASYGTIKIGIYQSLKRLFVERLEDETLL-INMICGVVSGVISSTIANPTDVLK 166
Query: 139 VRLQAQSHLHGIKPRYTGTY-NAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDL 197
+R+QAQ L + G+ ++ I EG GLW+G P R+ I+ EL YD+
Sbjct: 167 IRMQAQGSL------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 220
Query: 198 MKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPP-----GQYKSVP 252
K+ + + ++ D + H VS+ G S+PVDVV+TR +N YK
Sbjct: 221 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTV 280
Query: 253 NCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+ +K++ +EG A +KG P++LRLG WN+I F+ +EQLKR
Sbjct: 281 DGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 322
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/188 (23%), Positives = 80/188 (42%), Gaps = 6/188 (3%)
Query: 12 TLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGR 71
TL + + ++ ++ I P D K+R+Q QG S+I G+ + + EG
Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMI------GSFIDIYQQEGT 193
Query: 72 MKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIG 131
L+ G+ QR + + +YD ++ L ++ + ++ T G
Sbjct: 194 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 253
Query: 132 QPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTE 191
P +VV+ R+ Q + G Y GT + + EG L+KG PN +R N
Sbjct: 254 NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 313
Query: 192 LVTYDLMK 199
+TY+ +K
Sbjct: 314 FITYEQLK 321
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 172 bits (435), Expect = 4e-43
Identities = 97/282 (34%), Positives = 157/282 (55%), Gaps = 15/282 (5%)
Query: 21 GIAACLADVITFPLDTAKVRLQVQGECPTSSV--IRYKGVLGTITAVVKTEGRMKLYSGL 78
G+A+ +A+ TFP+D K RLQVQG+ + I+Y+G+ + + K EG + LYSG+
Sbjct: 45 GLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGI 104
Query: 79 PAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVK 138
L RQ S +++IG+Y +++ E L ++ G+ +G ++ I PT+V+K
Sbjct: 105 APALLRQASYGTIKIGIYQSLKRLFVERLEDETLL-INMICGVVSGVISSTIANPTDVLK 163
Query: 139 VRLQAQSHLHGIKPRYTGTY-NAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDL 197
+R+QAQ L + G+ ++ I EG GLW+G P R+ I+ EL YD+
Sbjct: 164 IRMQAQGSL------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
Query: 198 MKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPP-----GQYKSVP 252
K+ + + ++ D + H VS+ G S+PVDVV+TR +N YK
Sbjct: 218 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTV 277
Query: 253 NCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+ +K++ +EG A +KG P++LRLG WN+I F+ +EQLKR
Sbjct: 278 DGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/188 (23%), Positives = 80/188 (42%), Gaps = 6/188 (3%)
Query: 12 TLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGR 71
TL + + ++ ++ I P D K+R+Q QG S+I G+ + + EG
Sbjct: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMI------GSFIDIYQQEGT 190
Query: 72 MKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIG 131
L+ G+ QR + + +YD ++ L ++ + ++ T G
Sbjct: 191 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 250
Query: 132 QPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTE 191
P +VV+ R+ Q + G Y GT + + EG L+KG PN +R N
Sbjct: 251 NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 310
Query: 192 LVTYDLMK 199
+TY+ +K
Sbjct: 311 FITYEQLK 318
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 171 bits (434), Expect = 6e-43
Identities = 92/294 (31%), Positives = 166/294 (56%), Gaps = 17/294 (5%)
Query: 20 AGIAACLADVITFPLDTAKVRLQVQGECPTSSV-------IRYKGVLGTITAVVKTEGRM 72
+G AA +A++ TFPLD K RLQ+QGE + + Y+G++ T +++ EG +
Sbjct: 26 SGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFL 85
Query: 73 KLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAP-SLGSKILAGLTTGGVAVFIG 131
KL+ G+ + R + + R+ Y+ ++E + E L ++ G+ G + F+
Sbjct: 86 KLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLA 145
Query: 132 QPTEVVKVRLQAQSH--LHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINC 189
PT++VKV++Q + L G R+ G ++A+ I G+ GLW G PN+ R+ ++N
Sbjct: 146 NPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNM 205
Query: 190 TELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQ-- 247
+L TYD +K V N L D++ H +S+L +G A+ + +P DV+K+R +N P +
Sbjct: 206 GDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQG 265
Query: 248 ----YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELS 297
YKS +C ++ EG + +KG +PS+LR+ W+++ ++ +E++ RE+S
Sbjct: 266 RGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKI-REMS 318
Score = 60.5 bits (145), Expect = 2e-09
Identities = 46/197 (23%), Positives = 86/197 (43%), Gaps = 2/197 (1%)
Query: 6 ASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECP-TSSVIRYKGVLGTITA 64
+ D H L + +A + + P D KV++Q++G+ +R++GV
Sbjct: 120 SEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAK 179
Query: 65 VVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG 124
++ G L++G +QR + YDTV+ +L ++ + L+ L +G
Sbjct: 180 ILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSG 239
Query: 125 GVAVFIGQPTEVVKVRLQAQSH-LHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMR 183
VA +G P +V+K R+ Q G Y + + EG L+KG P+ +R
Sbjct: 240 LVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLR 299
Query: 184 SVIINCTELVTYDLMKE 200
+ +TY+ ++E
Sbjct: 300 MTPWSMVFWLTYEKIRE 316
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 170 bits (430), Expect = 2e-42
Identities = 97/298 (32%), Positives = 150/298 (50%), Gaps = 7/298 (2%)
Query: 2 GGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGT 61
GG+ V+ G+A A V PLD K R+Q+ GE + YK
Sbjct: 10 GGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGE--GAKTREYKTSFHA 67
Query: 62 ITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGL 121
+T+++K EG +Y+GL AGL RQ + + R+G+Y + E LT T P K + G+
Sbjct: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGM 127
Query: 122 TTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPR-YTGTYNAYRIIATTEGLTGLWKGTTPN 180
T G F+G P EV +R+ A L + R Y +NA I EG+ LW+G P
Sbjct: 128 TAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPT 187
Query: 181 LMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF 240
+ R+V++N +L +Y K+ + + +D++ CH +++I+G TA S PVD+ KTR
Sbjct: 188 MARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRI 247
Query: 241 IN----SPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
N +YK+ + KV EG + +KG P + RLG V+ F+ EQ+ +
Sbjct: 248 QNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
Score = 61.6 bits (148), Expect = 8e-10
Identities = 52/198 (26%), Positives = 82/198 (41%), Gaps = 10/198 (5%)
Query: 109 TAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPR-YTGTYNAYRIIATT 167
T+P + GL G VF+ QP ++VK R+Q G K R Y +++A I
Sbjct: 18 TSPKSVKFLFGGLAGMGATVFV-QPLDLVKNRMQLSGE--GAKTREYKTSFHALTSILKA 74
Query: 168 EGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCAT 227
EGL G++ G + L+R T L Y ++ E + V + AG
Sbjct: 75 EGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGA 134
Query: 228 AMSSPVDVVKTRFINS---PPGQ---YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSW 281
+ +P +V R P Q YK+V N +++ EG ++G +P+ R
Sbjct: 135 FVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVV 194
Query: 282 NVIMFVCFEQLKRELSKS 299
N + Q K+ L S
Sbjct: 195 NAAQLASYSQSKQFLLDS 212
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 162 bits (410), Expect = 3e-40
Identities = 99/278 (35%), Positives = 150/278 (53%), Gaps = 10/278 (3%)
Query: 18 FSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSG 77
+ G+A+C A T PLD KV LQ Q E + G VV+T+G + LYSG
Sbjct: 11 YFGGLASCGAACCTHPLDLLKVHLQTQQEVKLR-------MTGMALRVVRTDGILALYSG 63
Query: 78 LPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVV 137
L A L RQ++ + R +Y+TV++ + G + K+L G +G F+G P ++V
Sbjct: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
Query: 138 KVRLQAQSHL-HGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
VR+Q L G + Y + +A EGL L+ G T R ++ +L YD
Sbjct: 124 NVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYD 183
Query: 197 LMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAM 256
K+ + L+D++ H V++ IAG CAT + P+DV+KTR +NS G+Y+ V +CA+
Sbjct: 184 QAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS-KGEYQGVFHCAV 242
Query: 257 KVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+ GP AF+KGLVP+ +RL V+ FV EQL++
Sbjct: 243 ET-AKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 129 bits (325), Expect = 2e-30
Identities = 90/292 (30%), Positives = 138/292 (47%), Gaps = 17/292 (5%)
Query: 15 VQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIR--YKGVLGTITAVVKTEGRM 72
V L A CLA V T PL+ K RLQ+QGE Y G + ++ AV + +G
Sbjct: 8 VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLW 67
Query: 73 KLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQ 132
L GL AGL Q +R Y + AG P G ++AG G + F+G
Sbjct: 68 GLQKGLAAGLLYQGLMNGVRFYCYSLACQ---AGLTQQP--GGTVVAGAVAGALGAFVGS 122
Query: 133 PTEVVKVRLQAQSHLH---GIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINC 189
P ++K +LQAQ+ G + + A I +GL GLW+G + R ++ +
Sbjct: 123 PAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSA 182
Query: 190 TELVTYDLMKEAFVKNNILADDV-PCHLVSALIAGFCATAMSSPVDVVKTRFINSPP--- 245
+L T+ K K L +D L +I+ + +P DVV TR N P
Sbjct: 183 AQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTA 242
Query: 246 --GQ-YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
GQ Y + +C +K++ EGP A +KGL P++LRLG ++ + +++L++
Sbjct: 243 GRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 102 bits (255), Expect = 3e-22
Identities = 85/307 (27%), Positives = 133/307 (43%), Gaps = 38/307 (12%)
Query: 18 FSAGIAACLADV-ITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
F AG + V + +PLDT KVR+Q + +Y G+ + E Y
Sbjct: 3 FVAGAIGGVCGVAVGYPLDTVKVRIQTEP--------KYTGIWHCVRDTYHRERVWGFYR 54
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLT----AGKETAPSLGSKILAGLTTGGVAVFIGQ 132
GL + +S+ G Y + + P+ L+G +G V VF+
Sbjct: 55 GLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTS 114
Query: 133 PTEVVKVRLQAQSHLHGIK-----------------------PRYTGTYNAYRIIATTEG 169
PTEV KVRLQ Q+ + P+Y G + +A EG
Sbjct: 115 PTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEG 174
Query: 170 LTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAM 229
L GL+KG++ ++R T ++Y ++ E DVP LV+ AG A A+
Sbjct: 175 LCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAV 234
Query: 230 SSPVDVVKTRFINSPPGQ--YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFV 287
++P+DV+K+R GQ Y+ + +C + EGP FKGLV + R N+++FV
Sbjct: 235 ATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFV 294
Query: 288 CFEQLKR 294
+E + R
Sbjct: 295 AYEAVLR 301
Score = 61.2 bits (147), Expect = 1e-09
Identities = 55/211 (26%), Positives = 83/211 (39%), Gaps = 25/211 (11%)
Query: 8 DVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE-------------------CP 48
D PT S + + +T P + AKVRLQ Q + CP
Sbjct: 90 DAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCP 149
Query: 49 TSSVI---RYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTA 105
+Y+G L + V + EG LY G A + R S + Y + E+L+
Sbjct: 150 VPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSP 209
Query: 106 GKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIA 165
+ P + ++AG G +A + P +V+K RLQA + RY G +
Sbjct: 210 AGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQ---GQRRYRGLLHCMVTSV 266
Query: 166 TTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
EG L+KG N R+ +N V Y+
Sbjct: 267 REEGPRVLFKGLVLNCCRAFPVNMVVFVAYE 297
Score = 37.7 bits (86), Expect = 0.013
Identities = 24/73 (32%), Positives = 34/73 (46%), Gaps = 4/73 (5%)
Query: 6 ASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAV 65
A P + L + G A LA + P+D K RLQ G+ RY+G+L +
Sbjct: 210 AGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQ----GQRRYRGLLHCMVTS 265
Query: 66 VKTEGRMKLYSGL 78
V+ EG L+ GL
Sbjct: 266 VREEGPRVLFKGL 278
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 99.4 bits (246), Expect = 4e-21
Identities = 77/295 (26%), Positives = 138/295 (46%), Gaps = 10/295 (3%)
Query: 10 HPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTE 69
HP G + + G+A + ITFP + K +LQ+ S RY+G+ + V++
Sbjct: 24 HP--GKAILAGGLAGGIEICITFPTEYVKTQLQLDER---SHPPRYRGIGDCVRQTVRSH 78
Query: 70 GRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG-GVAV 128
G + LY GL + L I A++R G+++ + + + S +L GL G AV
Sbjct: 79 GVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRG-LLCGLGAGVAEAV 137
Query: 129 FIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIIN 188
+ P E +KV+ P+Y G ++ R I +GL G ++G T +++
Sbjct: 138 VVVCPMETIKVKFIHDQT--SPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQ 195
Query: 189 CTELVTYDLMKEAFVKNNILADDVPCHL-VSALIAGFCATAMSSPVDVVKTRFINSPPGQ 247
++ + +N P V IAG + ++P+DV+KTR +
Sbjct: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255
Query: 248 YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQT 302
Y++ +C +++ EG AF+KG VP R+ I+FV ++++ + L+K +T
Sbjct: 256 YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKT 310
Score = 63.2 bits (152), Expect = 3e-10
Identities = 53/198 (26%), Positives = 87/198 (43%), Gaps = 17/198 (8%)
Query: 105 AGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRII 164
+GK G ILAG GG+ + I PTE VK +LQ H PRY G + R
Sbjct: 17 SGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH--PPRYRGIGDCVRQT 74
Query: 165 ATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILAD-----DVPCHLVSA 219
+ G+ GL++G + L S+ ++ + +N + D D L+
Sbjct: 75 VRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFL------SNHMRDAQGRLDSTRGLLCG 128
Query: 220 LIAGFC-ATAMSSPVDVVKTRFIN---SPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSF 275
L AG A + P++ +K +FI+ SP +Y+ + ++ +G ++GL +
Sbjct: 129 LGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATV 188
Query: 276 LRLGSWNVIMFVCFEQLK 293
L+ GS I F L+
Sbjct: 189 LKQGSNQAIRFFVMTSLR 206
>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
Length = 295
Score = 97.8 bits (242), Expect = 1e-20
Identities = 70/233 (30%), Positives = 106/233 (45%), Gaps = 9/233 (3%)
Query: 20 AGIAACLADVITFPLDTAKVRLQVQGE--CPTSSVIRYKGVLGTITAVVKTEGRMKLYSG 77
+G+AAC A V T PL+ K R+Q+QGE P + Y+ V + K +G L G
Sbjct: 6 SGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKG 65
Query: 78 LPAGLQRQISSASLRIGLYDTVQE--FLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTE 135
L L Q +R+G Y + +L + T S AG G + ++G P
Sbjct: 66 LAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTH-SPARSAAAGAMAGVMGAYLGSPIY 124
Query: 136 VVKVRLQAQSHLH---GIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTEL 192
+VK LQAQ+ G + ++ G + A I GL GLW+G L R ++ + T+L
Sbjct: 125 MVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQL 184
Query: 193 VTYDLMKEAFVKNNIL-ADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSP 244
T+ K+ + I LV+A+++G +P DV TR N P
Sbjct: 185 CTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQP 237
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 96.3 bits (238), Expect = 3e-20
Identities = 80/280 (28%), Positives = 122/280 (43%), Gaps = 11/280 (3%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G + PLDT KVRLQ Q Y G + EG LY
Sbjct: 14 LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
Query: 77 GLPA---GLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQP 133
G+ A G+ + GL +Q+ + P L AG+ +G I P
Sbjct: 74 GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQL---FAAGMLSGVFTTGIMTP 130
Query: 134 TEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELV 193
E +K LQ Q+ + +YTGT + + + G+ G++KGT LMR V + +
Sbjct: 131 GERIKCLLQIQASSG--ESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFM 188
Query: 194 TYDLMKEAFVKNNILADDV--PCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQY-KS 250
TY+ +K F ++ P LV+ IAG A++ P DV+K+RF +PPG+Y
Sbjct: 189 TYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNG 248
Query: 251 VPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFE 290
+ ++ +EG T+ +KG +R N F+ FE
Sbjct: 249 FRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
Score = 69.3 bits (168), Expect = 4e-12
Identities = 50/181 (27%), Positives = 86/181 (47%), Gaps = 4/181 (2%)
Query: 117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQS-HLHGIKPRYTGTYNAYRIIATTEGLTGLWK 175
+LAG G VF+G P + VKVRLQ Q L G P Y+GT++ +R EG+TGL++
Sbjct: 14 LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
Query: 176 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 235
G ++ + + L K+ K+ P + +++G T + +P +
Sbjct: 74 GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGER 133
Query: 236 VKTRF---INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQL 292
+K +S +Y +CA K++ G +KG V + +R + + F+ +E L
Sbjct: 134 IKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWL 193
Query: 293 K 293
K
Sbjct: 194 K 194
Score = 43.5 bits (101), Expect = 2e-04
Identities = 47/188 (25%), Positives = 82/188 (43%), Gaps = 16/188 (8%)
Query: 16 QLFSAG-IAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKL 74
QLF+AG ++ I P + K LQ+Q +S +Y G L + + G +
Sbjct: 112 QLFAAGMLSGVFTTGIMTPGERIKCLLQIQA---SSGESKYTGTLDCAKKLYQEFGIRGI 168
Query: 75 YSGLPAGLQRQISSASLRIGLYDTVQEFLTA-GKETAPSLGSKILAGLTTGGVA-VF--- 129
Y G L R + ++ + Y+ ++ T GK + +IL GG+A +F
Sbjct: 169 YKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVA---GGIAGIFNWA 225
Query: 130 IGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINC 189
+ P +V+K R Q G P G + R + EG+T L+KG ++R+ N
Sbjct: 226 VAIPPDVLKSRFQTAPP--GKYPN--GFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANA 281
Query: 190 TELVTYDL 197
+ +++
Sbjct: 282 ACFLGFEV 289
Score = 34.3 bits (77), Expect = 0.14
Identities = 19/81 (23%), Positives = 31/81 (38%), Gaps = 6/81 (7%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRFINSPPG------QYKSVPNCAMKVFTNEGPTAFF 268
+L++ G C + P+D VK R PP Y +C K EG T +
Sbjct: 13 NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
Query: 269 KGLVPSFLRLGSWNVIMFVCF 289
+G+ + + + F F
Sbjct: 73 RGMAAPIIGVTPMFAVCFFGF 93
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 92.0 bits (227), Expect = 6e-19
Identities = 75/277 (27%), Positives = 120/277 (43%), Gaps = 12/277 (4%)
Query: 22 IAACLADVITFPLDTAKVRLQVQ-GECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPA 80
+A + +P+D K R+Q Q G + YK V++ EG LY GL
Sbjct: 335 VAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIP 394
Query: 81 GLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVR 140
L ++++ + D V++ T + P L +++LAG GG V P E+VK+R
Sbjct: 395 QLIGVAPEKAIKLTVNDFVRDKFTRRDGSVP-LPAEVLAGGCAGGSQVIFTNPLEIVKIR 453
Query: 141 LQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKE 200
LQ + TG + + G+ GL+KG +R + + Y K
Sbjct: 454 LQVAGEIT------TGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKL 507
Query: 201 AFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQ--YKSVPNCAMK 257
N + L + +AG A ++ +P DV+KTR + + GQ Y V +C K
Sbjct: 508 LLADENGHVGGLNL-LAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 566
Query: 258 VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+ EGP+AF+KG R + V +E L+R
Sbjct: 567 ILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603
Score = 67.8 bits (164), Expect = 1e-11
Identities = 56/198 (28%), Positives = 84/198 (42%), Gaps = 10/198 (5%)
Query: 5 TASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITA 64
T D L ++ + G A + T PL+ K+RLQV GE T + VL +
Sbjct: 418 TRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDL-- 475
Query: 65 VVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG 124
G LY G A R I +++ +Y + L L + + AG G
Sbjct: 476 -----GIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGL-NLLAAGAMAG 529
Query: 125 GVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRS 184
A + P +V+K RLQ + + Y+G + +R I EG + WKGT + RS
Sbjct: 530 VPAASLVTPADVIKTRLQVAARAG--QTTYSGVIDCFRKILREEGPSAFWKGTAARVFRS 587
Query: 185 VIINCTELVTYDLMKEAF 202
LVTY+L++ F
Sbjct: 588 SPQFGVTLVTYELLQRWF 605
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 90.1 bits (222), Expect = 2e-18
Identities = 69/293 (23%), Positives = 130/293 (44%), Gaps = 17/293 (5%)
Query: 12 TLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPT-SSVIRYKGVLGTITAVVKTEG 70
+ G L + G+AA ++ P++ K+ LQVQ S RYKG++ + + + +G
Sbjct: 19 SFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQG 78
Query: 71 RMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVA--- 127
+ G A + R + +L D ++ +G LA L +GG A
Sbjct: 79 FFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGAT 138
Query: 128 -VFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVI 186
+ + P + + RL + ++ G + IA ++G+ GL++G ++ ++
Sbjct: 139 SLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIV 198
Query: 187 INCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGF---CATAMSSPVDVVKTRFI-- 241
+ YD +K K LVS IA C+ +S P D V+ R +
Sbjct: 199 YRASYFGAYDTVKGLLPKPKKTP-----FLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQ 253
Query: 242 -NSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
QYK +C +K++ +EG ++FF+G + LR G+ ++ V ++++K
Sbjct: 254 SGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLR-GTGGALVLVLYDKIK 305
Score = 68.6 bits (166), Expect = 7e-12
Identities = 58/187 (31%), Positives = 90/187 (48%), Gaps = 8/187 (4%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQ-GECPTSSVIRYKGVLGTITAVVKTEGRMKLY 75
L S G A + + +PLD A+ RL V G+ P ++KG+ I + K++G LY
Sbjct: 129 LASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEER--QFKGLGDCIMKIAKSDGIAGLY 186
Query: 76 SGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTE 135
G +Q I + G YDTV+ L K+T P L S +A + T + + P +
Sbjct: 187 QGFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKT-PFLVSFFIAQVVTTCSGI-LSYPFD 244
Query: 136 VVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTY 195
V+ R+ QS K +Y GT + + I EG++ ++G N++R LV Y
Sbjct: 245 TVRRRMMMQS--GEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGT-GGALVLVLY 301
Query: 196 DLMKEAF 202
D +KE F
Sbjct: 302 DKIKEFF 308
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/204 (25%), Positives = 83/204 (40%), Gaps = 11/204 (5%)
Query: 110 APSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATT 167
A S G +LAG V+ P E VK+ LQ Q+ I P RY G + I
Sbjct: 17 ASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPRE 76
Query: 168 EGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFV----KNNILADDVPCHLVSALIAG 223
+G W+G N++R D K+ F+ K +L S AG
Sbjct: 77 QGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAG 136
Query: 224 FCATAMSSPVDVVKTRF---INSPPG--QYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRL 278
+ + P+D +TR I P Q+K + +C MK+ ++G ++G S +
Sbjct: 137 ATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGI 196
Query: 279 GSWNVIMFVCFEQLKRELSKSRQT 302
+ F ++ +K L K ++T
Sbjct: 197 IVYRASYFGAYDTVKGLLPKPKKT 220
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 89.0 bits (219), Expect = 5e-18
Identities = 68/285 (23%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L S +A ++ T PLD AKV +QV SS + +LG + ++V+ G L+
Sbjct: 96 LLSGAMAGAVSRTGTAPLDRAKVYMQVY-----SSKTNFTNLLGGLQSMVQEGGFRSLWR 150
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + +++ +++ + + G + +P ++LAG ++ + P EV
Sbjct: 151 GNGINVLKIAPEYAIKFSVFEQCKNYF-CGIQGSPPFQERLLAGSLAVAISQTLINPMEV 209
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K RL + +Y G + R I EG L++G PN++ + CT+L Y+
Sbjct: 210 LKTRLTLRR-----TGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYE 264
Query: 197 LMKEAFVKNNILADDVPCHLV---SALIAGFCATAMSSPVDVVKTRF--INSPPGQYKSV 251
+++ +VK+ D P LV S ++ C S P+ +V+TR ++ G ++
Sbjct: 265 MLQCFWVKSGRDMGD-PSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPTM 323
Query: 252 PNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKREL 296
++ +G ++G+ P+ L++ I +V +E +K+ L
Sbjct: 324 RGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKTL 368
Score = 64.3 bits (155), Expect = 1e-10
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 17/195 (8%)
Query: 11 PTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEG 70
P +L + +A ++ + P++ K RL ++ +YKG+L +++ EG
Sbjct: 184 PPFQERLLAGSLAVAISQTLINPMEVLKTRLTLR------RTGQYKGLLDCARQILQREG 237
Query: 71 RMKLYSGLPAGLQRQISSASLRIGLYDTVQEF-LTAGKETAPSLG----SKILAGLTTGG 125
LY G + I A + +Y+ +Q F + +G++ G S + T G
Sbjct: 238 TRALYRGYLPNMLGIIPYACTDLAVYEMLQCFWVKSGRDMGDPSGLVSLSSVTLSTTCGQ 297
Query: 126 VAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSV 185
+A + P +V+ R+QAQ + G P G RI+A +G GL++G TP L++ +
Sbjct: 298 MASY---PLTLVRTRMQAQDTVEGSNPTMRGVLQ--RILAQ-QGWLGLYRGMTPTLLKVL 351
Query: 186 IINCTELVTYDLMKE 200
V Y+ MK+
Sbjct: 352 PAGGISYVVYEAMKK 366
Score = 57.4 bits (137), Expect = 2e-08
Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 13/191 (6%)
Query: 117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKG 176
+L+G G V+ P + KV +Q S K +T + + G LW+G
Sbjct: 96 LLSGAMAGAVSRTGTAPLDRAKVYMQVYSS----KTNFTNLLGGLQSMVQEGGFRSLWRG 151
Query: 177 TTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMS----SP 232
N+++ + ++ K F + P L+AG A A+S +P
Sbjct: 152 NGINVLKIAPEYAIKFSVFEQCKNYFCG---IQGSPPFQ--ERLLAGSLAVAISQTLINP 206
Query: 233 VDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQL 292
++V+KTR GQYK + +CA ++ EG A ++G +P+ L + + +E L
Sbjct: 207 MEVLKTRLTLRRTGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYEML 266
Query: 293 KRELSKSRQTM 303
+ KS + M
Sbjct: 267 QCFWVKSGRDM 277
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 86.7 bits (213), Expect = 2e-17
Identities = 72/277 (25%), Positives = 119/277 (42%), Gaps = 12/277 (4%)
Query: 22 IAACLADVITFPLDTAKVRLQVQGECPTS-SVIRYKGVLGTITAVVKTEGRMKLYSGLPA 80
+A + +P+D K R+Q Q + + YK V++ EG LY GL
Sbjct: 337 VAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLP 396
Query: 81 GLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVR 140
L ++++ + D V++ + P L ++ILAG GG V P E+VK+R
Sbjct: 397 QLLGVAPEKAIKLTVNDFVRDKFMHKDGSVP-LAAEILAGGCAGGSQVIFTNPLEIVKIR 455
Query: 141 LQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKE 200
LQ + TG + + G G++KG +R + + Y +K
Sbjct: 456 LQVAGEI------TTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 509
Query: 201 AFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQ--YKSVPNCAMK 257
+F + L++ IAG A ++ +P DV+KTR + + GQ Y V +C K
Sbjct: 510 SFANEDGQVSPGSL-LLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 568
Query: 258 VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+ EGP A +KG R + + +E L+R
Sbjct: 569 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605
Score = 74.3 bits (181), Expect = 1e-13
Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 10/190 (5%)
Query: 13 LGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRM 72
L ++ + G A + T PL+ K+RLQV GE T + + +VV+ G
Sbjct: 428 LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRV-------SALSVVRDLGFF 480
Query: 73 KLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQ 132
+Y G A R I +++ Y V+ A ++ S GS +LAG G A +
Sbjct: 481 GIYKGAKACFLRDIPFSAIYFPCYAHVKASF-ANEDGQVSPGSLLLAGAIAGMPAASLVT 539
Query: 133 PTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTEL 192
P +V+K RLQ + + Y+G + +R I EG LWKG + RS L
Sbjct: 540 PADVIKTRLQVAARAG--QTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTL 597
Query: 193 VTYDLMKEAF 202
+TY+L++ F
Sbjct: 598 LTYELLQRWF 607
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 86.7 bits (213), Expect = 2e-17
Identities = 72/277 (25%), Positives = 119/277 (42%), Gaps = 12/277 (4%)
Query: 22 IAACLADVITFPLDTAKVRLQVQGECPTS-SVIRYKGVLGTITAVVKTEGRMKLYSGLPA 80
+A + +P+D K R+Q Q + + YK V++ EG LY GL
Sbjct: 338 VAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLP 397
Query: 81 GLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVR 140
L ++++ + D V++ + P L ++ILAG GG V P E+VK+R
Sbjct: 398 QLLGVAPEKAIKLTVNDFVRDKFMHKDGSVP-LAAEILAGGCAGGSQVIFTNPLEIVKIR 456
Query: 141 LQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKE 200
LQ + TG + + G G++KG +R + + Y +K
Sbjct: 457 LQVAGEI------TTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 510
Query: 201 AFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQ--YKSVPNCAMK 257
+F + L++ IAG A ++ +P DV+KTR + + GQ Y V +C K
Sbjct: 511 SFANEDGQVSPGSL-LLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 569
Query: 258 VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
+ EGP A +KG R + + +E L+R
Sbjct: 570 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606
Score = 74.3 bits (181), Expect = 1e-13
Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 10/190 (5%)
Query: 13 LGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRM 72
L ++ + G A + T PL+ K+RLQV GE T + + +VV+ G
Sbjct: 429 LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRV-------SALSVVRDLGFF 481
Query: 73 KLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQ 132
+Y G A R I +++ Y V+ A ++ S GS +LAG G A +
Sbjct: 482 GIYKGAKACFLRDIPFSAIYFPCYAHVKASF-ANEDGQVSPGSLLLAGAIAGMPAASLVT 540
Query: 133 PTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTEL 192
P +V+K RLQ + + Y+G + +R I EG LWKG + RS L
Sbjct: 541 PADVIKTRLQVAARAG--QTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTL 598
Query: 193 VTYDLMKEAF 202
+TY+L++ F
Sbjct: 599 LTYELLQRWF 608
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 86.7 bits (213), Expect = 2e-17
Identities = 78/280 (27%), Positives = 123/280 (43%), Gaps = 11/280 (3%)
Query: 16 QLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLY 75
Q+ + G A + + PLD K R Q+Q C T YK ++ + + + EG Y
Sbjct: 16 QIVAGGSAGLVEICLMHPLDVVKTRFQIQ-RCATDPN-SYKSLVDSFRMIFQMEGLFGFY 73
Query: 76 SGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTE 135
G+ + + +++ ++ ++ L +P+L I AGL +G + P E
Sbjct: 74 KGILPPILAETPKRAVKFFTFEQYKKLL-GYVSLSPALTFAI-AGLGSGLTEAIVVNPFE 131
Query: 136 VVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTY 195
VVKV LQA + +P G Y I GL GL KG T L R + N Y
Sbjct: 132 VVKVGLQANRNTFAEQPSTVG-YARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFY 190
Query: 196 DLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSP---PGQ--YKS 250
+K N + L++G A+ ++ P DV K+R I P PG+ Y++
Sbjct: 191 YNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSR-IQGPQPVPGEIKYRT 249
Query: 251 VPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFE 290
V+ EG A +KGL+P +RLG +M + +E
Sbjct: 250 CFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Score = 48.9 bits (115), Expect = 6e-06
Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 4/85 (4%)
Query: 216 LVSALIAGFCATAMSSPVDVVKTRF----INSPPGQYKSVPNCAMKVFTNEGPTAFFKGL 271
+V+ AG + P+DVVKTRF + P YKS+ + +F EG F+KG+
Sbjct: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
Query: 272 VPSFLRLGSWNVIMFVCFEQLKREL 296
+P L + F FEQ K+ L
Sbjct: 77 LPPILAETPKRAVKFFTFEQYKKLL 101
Score = 41.6 bits (96), Expect = 9e-04
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 22 IAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAG 81
++ +A VI P D AK R +QG P I+Y+ T+ V + EG + LY GL
Sbjct: 216 LSGTIASVINIPFDVAKSR--IQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPK 273
Query: 82 LQRQISSASLRIGLYDTVQEFL 103
+ R ++ + +Y+ +L
Sbjct: 274 IMRLGPGGAVMLLVYEYTYSWL 295
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 86.7 bits (213), Expect = 2e-17
Identities = 72/296 (24%), Positives = 131/296 (44%), Gaps = 25/296 (8%)
Query: 16 QLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLY 75
QL + GIA ++ T PLD K+ +QV G S + G +VK G L+
Sbjct: 197 QLLAGGIAGAVSRTSTAPLDRLKIMMQVHG-----SKSDKMNIFGGFRQMVKEGGIRSLW 251
Query: 76 SGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGS--KILAGLTTGGVAVFIGQP 133
G + + +++ Y+ ++ LT E +G+ + ++G G A P
Sbjct: 252 RGNGTNVIKIAPETAVKFWAYEQYKKLLT---EEGQKIGTFERFISGSMAGATAQTFIYP 308
Query: 134 TEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELV 193
EV+K RL G +Y+G Y+ + I EGL +KG PNL+ + +L
Sbjct: 309 MEVMKTRLAV-----GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLA 363
Query: 194 TYDLMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKS 250
Y+L+K ++ N + + V L ++ C S P+ +V+TR +
Sbjct: 364 VYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRM--QAQAMLEG 421
Query: 251 VPNCAM-----KVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQ 301
P M ++ + EG ++G+ P+F+++ I +V +E +K+ L +++
Sbjct: 422 SPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 477
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/206 (25%), Positives = 92/206 (44%), Gaps = 5/206 (2%)
Query: 88 SASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHL 147
S + IG T+ + T ++ + ++LAG G V+ P + +K+ +Q +
Sbjct: 169 STGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQ----V 224
Query: 148 HGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNI 207
HG K + +R + G+ LW+G N+++ + Y+ K+ +
Sbjct: 225 HGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQ 284
Query: 208 LADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAF 267
+S +AG A P++V+KTR GQY + +CA K+ +EG AF
Sbjct: 285 KIGTFE-RFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAF 343
Query: 268 FKGLVPSFLRLGSWNVIMFVCFEQLK 293
+KG VP+ L + + I +E LK
Sbjct: 344 YKGYVPNLLGIIPYAGIDLAVYELLK 369
Score = 32.0 bits (71), Expect = 0.71
Identities = 18/95 (18%), Positives = 43/95 (45%), Gaps = 3/95 (3%)
Query: 9 VHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKT 68
V+P + V L +++ + ++PL + R+Q Q S + ++G ++
Sbjct: 381 VNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQL---NMVGLFRRIISK 437
Query: 69 EGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFL 103
EG LY G+ + + + + +Y+ +++ L
Sbjct: 438 EGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 472
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 86.7 bits (213), Expect = 2e-17
Identities = 72/296 (24%), Positives = 131/296 (44%), Gaps = 25/296 (8%)
Query: 16 QLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLY 75
QL + GIA ++ T PLD K+ +QV G S + G +VK G L+
Sbjct: 178 QLLAGGIAGAVSRTSTAPLDRLKIMMQVHG-----SKSDKMNIFGGFRQMVKEGGIRSLW 232
Query: 76 SGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGS--KILAGLTTGGVAVFIGQP 133
G + + +++ Y+ ++ LT E +G+ + ++G G A P
Sbjct: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLT---EEGQKIGTFERFISGSMAGATAQTFIYP 289
Query: 134 TEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELV 193
EV+K RL G +Y+G Y+ + I EGL +KG PNL+ + +L
Sbjct: 290 MEVMKTRLAV-----GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLA 344
Query: 194 TYDLMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKS 250
Y+L+K ++ N + + V L ++ C S P+ +V+TR +
Sbjct: 345 VYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRM--QAQAMLEG 402
Query: 251 VPNCAM-----KVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQ 301
P M ++ + EG ++G+ P+F+++ I +V +E +K+ L +++
Sbjct: 403 SPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/206 (25%), Positives = 92/206 (44%), Gaps = 5/206 (2%)
Query: 88 SASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHL 147
S + IG T+ + T ++ + ++LAG G V+ P + +K+ +Q +
Sbjct: 150 STGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQ----V 205
Query: 148 HGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNI 207
HG K + +R + G+ LW+G N+++ + Y+ K+ +
Sbjct: 206 HGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQ 265
Query: 208 LADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAF 267
+S +AG A P++V+KTR GQY + +CA K+ +EG AF
Sbjct: 266 KIGTFE-RFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAF 324
Query: 268 FKGLVPSFLRLGSWNVIMFVCFEQLK 293
+KG VP+ L + + I +E LK
Sbjct: 325 YKGYVPNLLGIIPYAGIDLAVYELLK 350
Score = 32.0 bits (71), Expect = 0.71
Identities = 18/95 (18%), Positives = 43/95 (45%), Gaps = 3/95 (3%)
Query: 9 VHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKT 68
V+P + V L +++ + ++PL + R+Q Q S + ++G ++
Sbjct: 362 VNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQL---NMVGLFRRIISK 418
Query: 69 EGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFL 103
EG LY G+ + + + + +Y+ +++ L
Sbjct: 419 EGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 86.3 bits (212), Expect = 3e-17
Identities = 73/290 (25%), Positives = 128/290 (44%), Gaps = 15/290 (5%)
Query: 9 VHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKT 68
+HP + L + C + ++ PLD K RLQ P+ R G+L + VV+T
Sbjct: 24 LHPVIKAFLCGSISGTC-STLLFQPLDLLKTRLQTLQ--PSDHGSRRVGMLAVLLKVVRT 80
Query: 69 EGRMKLYSGLPAGLQRQISSASLRIG-LYDTVQEFLTAGKETAPSLGSKILAGLTTGGVA 127
E + L+ G+ + R + + G LY Q FL TA ++ G+ + VA
Sbjct: 81 ESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALE---SVMLGVGSRSVA 137
Query: 128 VFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVII 187
P V+K R ++ + Y Y A R I +EG GL+ G T L+R
Sbjct: 138 GVCMSPITVIKTRYESGKY------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPF 191
Query: 188 NCTELVTYDLMKEAFVKNNILADDVP-CHLVSALIAGFCATAMSSPVDVVKTRFINSPPG 246
+ L+ Y+ K + + A +P + + AG A+ ++ P DV+KT + P
Sbjct: 192 SGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTH-MQLYPL 250
Query: 247 QYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKREL 296
+++ + +F + G FF+G +P LR + + +E++ ++
Sbjct: 251 KFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKM 300
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 85.1 bits (209), Expect = 7e-17
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G A ++ T PLD KV +QV +S G++G T +++ G L+
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVH-----ASRSNNMGIVGGFTQMIREGGARSLWR 244
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + ++++ Y+ ++ + + +ET + +++AG G +A P EV
Sbjct: 245 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETL-RIHERLVAGSLAGAIAQSSIYPMEV 303
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K R+ + +Y+G + R I EG+ +KG PN++ + +L Y+
Sbjct: 304 LKTRMALRK-----TGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYE 358
Query: 197 LMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPN 253
+K A++++ N V L ++ C S P+ +V+TR + P
Sbjct: 359 TLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRM--QAQASIEGAPE 416
Query: 254 CAMK-----VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
M + EG ++GL P+F+++ I +V +E LK
Sbjct: 417 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 67.8 bits (164), Expect = 1e-11
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 5/196 (2%)
Query: 98 TVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGT 157
TV + T + ++AG G V+ P + +KV +Q +H + G
Sbjct: 171 TVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ----VHASRSNNMGI 226
Query: 158 YNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLV 217
+ + G LW+G N+++ + + + Y+ +K V ++ + LV
Sbjct: 227 VGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKR-LVGSDQETLRIHERLV 285
Query: 218 SALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLR 277
+ +AG A + P++V+KTR GQY + +CA ++ EG AF+KG VP+ L
Sbjct: 286 AGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLG 345
Query: 278 LGSWNVIMFVCFEQLK 293
+ + I +E LK
Sbjct: 346 IIPYAGIDLAVYETLK 361
Score = 30.0 bits (66), Expect = 2.7
Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVP 273
HLV+ AG + ++P+D +K +++ + ++ G + ++G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 274 SFLRLGSWNVIMFVCFEQLKRELSKSRQTM 303
+ L++ + I F+ +EQ+KR + ++T+
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLVGSDQETL 278
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 85.1 bits (209), Expect = 7e-17
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G A ++ T PLD KV +QV +S G++G T +++ G L+
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVH-----ASRSNNMGIVGGFTQMIREGGARSLWR 278
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + ++++ Y+ ++ + + +ET + +++AG G +A P EV
Sbjct: 279 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETL-RIHERLVAGSLAGAIAQSSIYPMEV 337
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K R+ + +Y+G + R I EG+ +KG PN++ + +L Y+
Sbjct: 338 LKTRMALRK-----TGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYE 392
Query: 197 LMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPN 253
+K A++++ N V L ++ C S P+ +V+TR + P
Sbjct: 393 TLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRM--QAQASIEGAPE 450
Query: 254 CAMK-----VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
M + EG ++GL P+F+++ I +V +E LK
Sbjct: 451 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 67.8 bits (164), Expect = 1e-11
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 5/196 (2%)
Query: 98 TVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGT 157
TV + T + ++AG G V+ P + +KV +Q +H + G
Sbjct: 205 TVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ----VHASRSNNMGI 260
Query: 158 YNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLV 217
+ + G LW+G N+++ + + + Y+ +K V ++ + LV
Sbjct: 261 VGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKR-LVGSDQETLRIHERLV 319
Query: 218 SALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLR 277
+ +AG A + P++V+KTR GQY + +CA ++ EG AF+KG VP+ L
Sbjct: 320 AGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLG 379
Query: 278 LGSWNVIMFVCFEQLK 293
+ + I +E LK
Sbjct: 380 IIPYAGIDLAVYETLK 395
Score = 30.0 bits (66), Expect = 2.7
Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVP 273
HLV+ AG + ++P+D +K +++ + ++ G + ++G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 274 SFLRLGSWNVIMFVCFEQLKRELSKSRQTM 303
+ L++ + I F+ +EQ+KR + ++T+
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLVGSDQETL 312
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 85.1 bits (209), Expect = 7e-17
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G A ++ T PLD KV +QV +S G++G T +++ G L+
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVH-----ASRSNNMGIVGGFTQMIREGGARSLWR 264
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + ++++ Y+ ++ + + +ET + +++AG G +A P EV
Sbjct: 265 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETL-RIHERLVAGSLAGAIAQSSIYPMEV 323
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K R+ + +Y+G + R I EG+ +KG PN++ + +L Y+
Sbjct: 324 LKTRMALRK-----TGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYE 378
Query: 197 LMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPN 253
+K A++++ N V L ++ C S P+ +V+TR + P
Sbjct: 379 TLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRM--QAQASIEGAPE 436
Query: 254 CAMK-----VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
M + EG ++GL P+F+++ I +V +E LK
Sbjct: 437 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 481
Score = 67.8 bits (164), Expect = 1e-11
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 5/196 (2%)
Query: 98 TVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGT 157
TV + T + ++AG G V+ P + +KV +Q +H + G
Sbjct: 191 TVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ----VHASRSNNMGI 246
Query: 158 YNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLV 217
+ + G LW+G N+++ + + + Y+ +K V ++ + LV
Sbjct: 247 VGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKR-LVGSDQETLRIHERLV 305
Query: 218 SALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLR 277
+ +AG A + P++V+KTR GQY + +CA ++ EG AF+KG VP+ L
Sbjct: 306 AGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLG 365
Query: 278 LGSWNVIMFVCFEQLK 293
+ + I +E LK
Sbjct: 366 IIPYAGIDLAVYETLK 381
Score = 30.0 bits (66), Expect = 2.7
Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVP 273
HLV+ AG + ++P+D +K +++ + ++ G + ++G
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 268
Query: 274 SFLRLGSWNVIMFVCFEQLKRELSKSRQTM 303
+ L++ + I F+ +EQ+KR + ++T+
Sbjct: 269 NVLKIAPESAIKFMAYEQIKRLVGSDQETL 298
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 85.1 bits (209), Expect = 7e-17
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G A ++ T PLD KV +QV +S G++G T +++ G L+
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVH-----ASRSNNMGIVGGFTQMIREGGARSLWR 244
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + ++++ Y+ ++ + + +ET + +++AG G +A P EV
Sbjct: 245 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETL-RIHERLVAGSLAGAIAQSSIYPMEV 303
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K R+ + +Y+G + R I EG+ +KG PN++ + +L Y+
Sbjct: 304 LKTRMALRK-----TGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYE 358
Query: 197 LMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPN 253
+K A++++ N V L ++ C S P+ +V+TR + P
Sbjct: 359 TLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRM--QAQASIEGAPE 416
Query: 254 CAMK-----VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
M + EG ++GL P+F+++ I +V +E LK
Sbjct: 417 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 67.8 bits (164), Expect = 1e-11
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 5/196 (2%)
Query: 98 TVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGT 157
TV + T + ++AG G V+ P + +KV +Q +H + G
Sbjct: 171 TVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ----VHASRSNNMGI 226
Query: 158 YNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLV 217
+ + G LW+G N+++ + + + Y+ +K V ++ + LV
Sbjct: 227 VGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKR-LVGSDQETLRIHERLV 285
Query: 218 SALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLR 277
+ +AG A + P++V+KTR GQY + +CA ++ EG AF+KG VP+ L
Sbjct: 286 AGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLG 345
Query: 278 LGSWNVIMFVCFEQLK 293
+ + I +E LK
Sbjct: 346 IIPYAGIDLAVYETLK 361
Score = 30.0 bits (66), Expect = 2.7
Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVP 273
HLV+ AG + ++P+D +K +++ + ++ G + ++G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 274 SFLRLGSWNVIMFVCFEQLKRELSKSRQTM 303
+ L++ + I F+ +EQ+KR + ++T+
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLVGSDQETL 278
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 85.1 bits (209), Expect = 7e-17
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G A ++ T PLD KV +QV +S G++G T +++ G L+
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVH-----ASRSNNMGIVGGFTQMIREGGARSLWR 141
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + ++++ Y+ ++ + + +ET + +++AG G +A P EV
Sbjct: 142 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETL-RIHERLVAGSLAGAIAQSSIYPMEV 200
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K R+ + +Y+G + R I EG+ +KG PN++ + +L Y+
Sbjct: 201 LKTRMALRK-----TGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYE 255
Query: 197 LMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPN 253
+K A++++ N V L ++ C S P+ +V+TR + P
Sbjct: 256 TLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRM--QAQASIEGAPE 313
Query: 254 CAMK-----VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
M + EG ++GL P+F+++ I +V +E LK
Sbjct: 314 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 358
Score = 67.8 bits (164), Expect = 1e-11
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 5/196 (2%)
Query: 98 TVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGT 157
TV + T + ++AG G V+ P + +KV +Q +H + G
Sbjct: 68 TVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ----VHASRSNNMGI 123
Query: 158 YNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLV 217
+ + G LW+G N+++ + + + Y+ +K V ++ + LV
Sbjct: 124 VGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKR-LVGSDQETLRIHERLV 182
Query: 218 SALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLR 277
+ +AG A + P++V+KTR GQY + +CA ++ EG AF+KG VP+ L
Sbjct: 183 AGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLG 242
Query: 278 LGSWNVIMFVCFEQLK 293
+ + I +E LK
Sbjct: 243 IIPYAGIDLAVYETLK 258
Score = 30.0 bits (66), Expect = 2.7
Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVP 273
HLV+ AG + ++P+D +K +++ + ++ G + ++G
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 145
Query: 274 SFLRLGSWNVIMFVCFEQLKRELSKSRQTM 303
+ L++ + I F+ +EQ+KR + ++T+
Sbjct: 146 NVLKIAPESAIKFMAYEQIKRLVGSDQETL 175
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 85.1 bits (209), Expect = 7e-17
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 17 LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76
L + G A ++ T PLD KV +QV +S G++G T +++ G L+
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVH-----ASRSNNMGIVGGFTQMIREGGARSLWR 278
Query: 77 GLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEV 136
G + + ++++ Y+ ++ + + +ET + +++AG G +A P EV
Sbjct: 279 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETL-RIHERLVAGSLAGAIAQSSIYPMEV 337
Query: 137 VKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
+K R+ + +Y+G + R I EG+ +KG PN++ + +L Y+
Sbjct: 338 LKTRMALRK-----TGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYE 392
Query: 197 LMKEAFVKN---NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPN 253
+K A++++ N V L ++ C S P+ +V+TR + P
Sbjct: 393 TLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRM--QAQASIEGAPE 450
Query: 254 CAMK-----VFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
M + EG ++GL P+F+++ I +V +E LK
Sbjct: 451 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 67.8 bits (164), Expect = 1e-11
Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 5/196 (2%)
Query: 98 TVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGT 157
TV + T + ++AG G V+ P + +KV +Q +H + G
Sbjct: 205 TVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ----VHASRSNNMGI 260
Query: 158 YNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLV 217
+ + G LW+G N+++ + + + Y+ +K V ++ + LV
Sbjct: 261 VGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKR-LVGSDQETLRIHERLV 319
Query: 218 SALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLR 277
+ +AG A + P++V+KTR GQY + +CA ++ EG AF+KG VP+ L
Sbjct: 320 AGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLG 379
Query: 278 LGSWNVIMFVCFEQLK 293
+ + I +E LK
Sbjct: 380 IIPYAGIDLAVYETLK 395
Score = 30.0 bits (66), Expect = 2.7
Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 215 HLVSALIAGFCATAMSSPVDVVKTRF-INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVP 273
HLV+ AG + ++P+D +K +++ + ++ G + ++G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 274 SFLRLGSWNVIMFVCFEQLKRELSKSRQTM 303
+ L++ + I F+ +EQ+KR + ++T+
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLVGSDQETL 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,789,475
Number of Sequences: 37866
Number of extensions: 448825
Number of successful extensions: 1350
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 752
Number of HSP's gapped (non-prelim): 220
length of query: 307
length of database: 18,247,518
effective HSP length: 102
effective length of query: 205
effective length of database: 14,385,186
effective search space: 2948963130
effective search space used: 2948963130
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.