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Search of human proteins with 169171014
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169171014 PREDICTED: similar to homeodomain interacting
protein kinase 2 [Homo sapiens]
(460 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 931 0.0
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 736 0.0
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 736 0.0
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 508 e-144
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 508 e-144
gi|169171552 PREDICTED: similar to homeodomain interacting prote... 502 e-142
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 436 e-122
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 436 e-122
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 171 2e-42
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 138 1e-32
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 138 1e-32
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 138 1e-32
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 137 2e-32
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 137 2e-32
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 137 2e-32
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 137 2e-32
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 137 2e-32
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 136 3e-32
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 132 5e-31
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 132 5e-31
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 120 3e-27
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 120 3e-27
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 114 1e-25
gi|10190706 CDC-like kinase 4 [Homo sapiens] 112 5e-25
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 112 7e-25
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 112 7e-25
gi|47717134 CDC-like kinase 2 [Homo sapiens] 109 5e-24
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 108 1e-23
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 108 1e-23
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 80 4e-15
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 931 bits (2405), Expect = 0.0
Identities = 460/460 (100%), Positives = 460/460 (100%)
Query: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
Query: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
Query: 361 YLQSRYYRPRADRRVYCCPSTCSPLPRPDQAIHSVPRWPQSQWQGEVSPGQEPPRKTRSL 420
YLQSRYYRPRADRRVYCCPSTCSPLPRPDQAIHSVPRWPQSQWQGEVSPGQEPPRKTRSL
Sbjct: 361 YLQSRYYRPRADRRVYCCPSTCSPLPRPDQAIHSVPRWPQSQWQGEVSPGQEPPRKTRSL 420
Query: 421 SLSPEEKDGQWLSESGGLGARAEETGRKIGDPSSGSLRQQ 460
SLSPEEKDGQWLSESGGLGARAEETGRKIGDPSSGSLRQQ
Sbjct: 421 SLSPEEKDGQWLSESGGLGARAEETGRKIGDPSSGSLRQQ 460
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 736 bits (1901), Expect = 0.0
Identities = 368/368 (100%), Positives = 368/368 (100%)
Query: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
Query: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
Query: 361 YLQSRYYR 368
YLQSRYYR
Sbjct: 361 YLQSRYYR 368
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 736 bits (1901), Expect = 0.0
Identities = 368/368 (100%), Positives = 368/368 (100%)
Query: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
Query: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
Query: 361 YLQSRYYR 368
YLQSRYYR
Sbjct: 361 YLQSRYYR 368
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 508 bits (1309), Expect = e-144
Identities = 263/364 (72%), Positives = 300/364 (82%), Gaps = 8/364 (2%)
Query: 8 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
MAS +QVFSP ++ SSAFCS KKLKIEPS WD++G S+ K Y+ SK +P +Q
Sbjct: 1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
Query: 68 STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124
++S V N ++P Y+Q ++ P + HIVVT+A SS S L RS VSLL+
Sbjct: 57 NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
Query: 125 TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184
YQKCGLKRKSEE+++ SVQIIEEHPP++ N + A ATT+T T+K+S S+ EGDY
Sbjct: 117 PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
Query: 185 QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244
QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 176 QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
Query: 245 SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304
SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 236 SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
Query: 305 LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364
LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 296 LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
Query: 365 RYYR 368
RYYR
Sbjct: 356 RYYR 359
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 508 bits (1309), Expect = e-144
Identities = 263/364 (72%), Positives = 300/364 (82%), Gaps = 8/364 (2%)
Query: 8 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
MAS +QVFSP ++ SSAFCS KKLKIEPS WD++G S+ K Y+ SK +P +Q
Sbjct: 1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
Query: 68 STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124
++S V N ++P Y+Q ++ P + HIVVT+A SS S L RS VSLL+
Sbjct: 57 NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
Query: 125 TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184
YQKCGLKRKSEE+++ SVQIIEEHPP++ N + A ATT+T T+K+S S+ EGDY
Sbjct: 117 PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
Query: 185 QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244
QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 176 QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
Query: 245 SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304
SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 236 SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
Query: 305 LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364
LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 296 LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
Query: 365 RYYR 368
RYYR
Sbjct: 356 RYYR 359
>gi|169171552 PREDICTED: similar to homeodomain interacting protein
kinase 3 [Homo sapiens]
Length = 264
Score = 502 bits (1293), Expect = e-142
Identities = 252/252 (100%), Positives = 252/252 (100%)
Query: 8 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV
Sbjct: 1 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 60
Query: 68 STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ 127
STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ
Sbjct: 61 STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ 120
Query: 128 KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV 187
KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
Sbjct: 121 KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV 180
Query: 188 QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL 247
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL
Sbjct: 181 QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL 240
Query: 248 ARLSTESADDYN 259
ARLSTESADDYN
Sbjct: 241 ARLSTESADDYN 252
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 436 bits (1122), Expect = e-122
Identities = 246/375 (65%), Positives = 277/375 (73%), Gaps = 23/375 (6%)
Query: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
Query: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
Query: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
Query: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
Query: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
Query: 354 SKAVCSTYLQSRYYR 368
SK VCSTYLQSRYYR
Sbjct: 352 SKTVCSTYLQSRYYR 366
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 436 bits (1122), Expect = e-122
Identities = 246/375 (65%), Positives = 277/375 (73%), Gaps = 23/375 (6%)
Query: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
Query: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
Query: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
Query: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
Query: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
Query: 354 SKAVCSTYLQSRYYR 368
SK VCSTYLQSRYYR
Sbjct: 352 SKTVCSTYLQSRYYR 366
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 171 bits (432), Expect = 2e-42
Identities = 92/177 (51%), Positives = 122/177 (68%), Gaps = 2/177 (1%)
Query: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253
S T+ Y+++E LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
Query: 254 SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALM 313
++ + +R E F LVFE+LEQNL++F K+N F+PLP ++IR V QV TAL
Sbjct: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
Query: 314 KLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYR 368
+LK L +IHADLKPENIMLVD +R P+RVKVIDFGSAS S+ V Y+QSR+YR
Sbjct: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYR 182
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 138 bits (347), Expect = 1e-32
Identities = 73/173 (42%), Positives = 107/173 (61%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 231 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 280
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 138 bits (347), Expect = 1e-32
Identities = 73/173 (42%), Positives = 107/173 (61%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 231 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 280
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 138 bits (347), Expect = 1e-32
Identities = 73/173 (42%), Positives = 107/173 (61%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 231 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 280
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 137 bits (345), Expect = 2e-32
Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 279 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 328
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 137 bits (345), Expect = 2e-32
Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 279 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 328
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 137 bits (345), Expect = 2e-32
Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 279 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 328
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 137 bits (345), Expect = 2e-32
Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 270 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 319
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 137 bits (345), Expect = 2e-32
Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 279 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 328
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 136 bits (343), Expect = 3e-32
Identities = 80/197 (40%), Positives = 111/197 (56%), Gaps = 7/197 (3%)
Query: 173 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 232
SK S + G Y V H+ + YEVLE +G+G+FGQV KC NE+VA+KI++N
Sbjct: 81 SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
Query: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQN 291
+ +Q +E+ IL L + D+ YN V + F +NH C+ FE+L NLY+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
Query: 292 KFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS 351
F L +R V L L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSC 255
Query: 352 HVSKAVCSTYLQSRYYR 368
+ + V TY+QSR+YR
Sbjct: 256 YEHQKV-YTYIQSRFYR 271
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 132 bits (333), Expect = 5e-31
Identities = 76/201 (37%), Positives = 112/201 (55%), Gaps = 8/201 (3%)
Query: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
T N G + +G Y V H+ + YEVL+ +G+G+FGQVVK + ++ VA+K
Sbjct: 195 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 251
Query: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
+++N + RQ E+ IL L + D+ N + E F +NH C+ FE+L NLY+
Sbjct: 252 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 311
Query: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
+K+NKF L +R + L L +IH DLKPENI+L R +KVIDF
Sbjct: 312 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRS--GIKVIDF 369
Query: 348 GSASHVSKAVCSTYLQSRYYR 368
GS+ + + V TY+QSR+YR
Sbjct: 370 GSSCYEHQRV-YTYIQSRFYR 389
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 132 bits (333), Expect = 5e-31
Identities = 76/201 (37%), Positives = 112/201 (55%), Gaps = 8/201 (3%)
Query: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
T N G + +G Y V H+ + YEVL+ +G+G+FGQVVK + ++ VA+K
Sbjct: 122 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 178
Query: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
+++N + RQ E+ IL L + D+ N + E F +NH C+ FE+L NLY+
Sbjct: 179 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 238
Query: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
+K+NKF L +R + L L +IH DLKPENI+L R +KVIDF
Sbjct: 239 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 296
Query: 348 GSASHVSKAVCSTYLQSRYYR 368
GS+ + + V TY+QSR+YR
Sbjct: 297 GSSCYEHQRV-YTYIQSRFYR 316
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 120 bits (301), Expect = 3e-27
Identities = 68/195 (34%), Positives = 106/195 (54%), Gaps = 5/195 (2%)
Query: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
N+G + D + H + YEVL+ +G+G+FGQV + + + VA+K+++N
Sbjct: 166 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 224
Query: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
+ RQ E+ IL L + N + E F +NH C+ FE+L +LY+ +K+NKF
Sbjct: 225 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 284
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
++ +R Q + +L L +IH DLKPENI+L R KVIDFGS+
Sbjct: 285 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS--STKVIDFGSSCFE 342
Query: 354 SKAVCSTYLQSRYYR 368
+ + TY+QSR+YR
Sbjct: 343 YQKL-YTYIQSRFYR 356
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 120 bits (301), Expect = 3e-27
Identities = 68/195 (34%), Positives = 106/195 (54%), Gaps = 5/195 (2%)
Query: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
N+G + D + H + YEVL+ +G+G+FGQV + + + VA+K+++N
Sbjct: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244
Query: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
+ RQ E+ IL L + N + E F +NH C+ FE+L +LY+ +K+NKF
Sbjct: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
++ +R Q + +L L +IH DLKPENI+L R KVIDFGS+
Sbjct: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS--STKVIDFGSSCFE 362
Query: 354 SKAVCSTYLQSRYYR 368
+ + TY+QSR+YR
Sbjct: 363 YQKL-YTYIQSRFYR 376
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 114 bits (286), Expect = 1e-25
Identities = 75/198 (37%), Positives = 115/198 (58%), Gaps = 9/198 (4%)
Query: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 232
+++ +++EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
Query: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ- 290
+ + G E+ L +L+ DD ++ +R + F HK H CLVFE L NL + LK+
Sbjct: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
Query: 291 NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA 350
K L +K +R QQ+ AL LK ++HAD+KP+NI LV+ S+ +K+ DFGSA
Sbjct: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKT--ILKLCDFGSA 838
Query: 351 SHVSKAVCSTYLQSRYYR 368
SHV+ + YL SR+YR
Sbjct: 839 SHVADNDITPYLVSRFYR 856
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 112 bits (281), Expect = 5e-25
Identities = 66/187 (35%), Positives = 104/187 (55%), Gaps = 18/187 (9%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-STESAD 256
YE+++ LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST+
Sbjct: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
Query: 257 DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
+ V+ E F H H C+VFE+L + YDF+K+N F P + +IR + Q+ ++ L
Sbjct: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
Query: 317 SLGLIHADLKPENIMLV---------------DPSRQPYRVKVIDFGSASHVSKAVCSTY 361
L H DLKPENI+ V + + + +KV+DFGSA++ + ST
Sbjct: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337
Query: 362 LQSRYYR 368
+ +R+YR
Sbjct: 338 VSTRHYR 344
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 112 bits (280), Expect = 7e-25
Identities = 67/187 (35%), Positives = 103/187 (55%), Gaps = 18/187 (9%)
Query: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
YE+++ LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T +
Sbjct: 203 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 262
Query: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
+ V+ E F+H H C+VFE+L + YDF+K+N F P L +IR + Q+ ++ L
Sbjct: 263 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 322
Query: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
S L H DLKPENI+ V + Y +KV+DFGSA++ + ST
Sbjct: 323 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 381
Query: 362 LQSRYYR 368
+ +R+YR
Sbjct: 382 VSTRHYR 388
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 112 bits (280), Expect = 7e-25
Identities = 67/187 (35%), Positives = 103/187 (55%), Gaps = 18/187 (9%)
Query: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
YE+++ LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T +
Sbjct: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
Query: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
+ V+ E F+H H C+VFE+L + YDF+K+N F P L +IR + Q+ ++ L
Sbjct: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
Query: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
S L H DLKPENI+ V + Y +KV+DFGSA++ + ST
Sbjct: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
Query: 362 LQSRYYR 368
+ +R+YR
Sbjct: 340 VSTRHYR 346
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 109 bits (273), Expect = 5e-24
Identities = 72/222 (32%), Positives = 122/222 (54%), Gaps = 23/222 (10%)
Query: 165 TATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC--WKRGTN 222
+++ S+ +K+ ++EG L+ H V + YE++ LG GTFG+VV+C +RG
Sbjct: 131 SSSHSSRRAKSVEDDAEG--HLIYH-VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGA 187
Query: 223 EIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNF-VRAYECFQHKNHTCLVFEMLE 281
VA+KI+KN Y ++E+++L +++ + D+ N V+ ++ F + H C+ FE+L
Sbjct: 188 R-VALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG 246
Query: 282 QNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-------- 333
+ +DFLK N + P P+ +R + Q+ A+ L L H DLKPENI+ V
Sbjct: 247 LSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTY 306
Query: 334 -------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
+ S + V+V+DFGSA+ ST + +R+YR
Sbjct: 307 NLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTIVSTRHYR 347
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 108 bits (269), Expect = 1e-23
Identities = 71/228 (31%), Positives = 121/228 (53%), Gaps = 27/228 (11%)
Query: 164 ATATTSTATSKNSGSNSEGDYQLVQHEVLCS----MTNTYEVLEFLGRGTFGQVVKCWK- 218
+ ++ S +SK S + E D + ++C + YE++ LG GTFG+VV+C
Sbjct: 268 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 324
Query: 219 -RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLV 276
RG ++ VA+KI++N Y ++E+++L ++ + ++ + V + F H C+
Sbjct: 325 ARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIA 383
Query: 277 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV--- 333
FE+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V
Sbjct: 384 FELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSE 443
Query: 334 ------------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRP 369
+ S + ++V DFGSA+ +T + +R+YRP
Sbjct: 444 FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRP 490
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 108 bits (269), Expect = 1e-23
Identities = 71/228 (31%), Positives = 121/228 (53%), Gaps = 27/228 (11%)
Query: 164 ATATTSTATSKNSGSNSEGDYQLVQHEVLCS----MTNTYEVLEFLGRGTFGQVVKCWK- 218
+ ++ S +SK S + E D + ++C + YE++ LG GTFG+VV+C
Sbjct: 120 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 176
Query: 219 -RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLV 276
RG ++ VA+KI++N Y ++E+++L ++ + ++ + V + F H C+
Sbjct: 177 ARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIA 235
Query: 277 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV--- 333
FE+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V
Sbjct: 236 FELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSE 295
Query: 334 ------------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRP 369
+ S + ++V DFGSA+ +T + +R+YRP
Sbjct: 296 FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRP 342
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 80.1 bits (196), Expect = 4e-15
Identities = 59/174 (33%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP--SYARQGQIEVSILARLSTESAD 256
YE L +G G++G V+KC + T +IVAIKI P S + E+ L + E
Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE--- 60
Query: 257 DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
N V E F+ K LVFE ++ + D L Q+ L K +R L Q+ A+ L
Sbjct: 61 --NLVNLIEVFRQKKKIHLVFEFIDHTVLDEL-QHYCHGLESKRLRKYLFQILRAIDYLH 117
Query: 317 SLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYR 368
S +IH D+KPENI++ Q K+ DFG A ++ + + Y+ +R+YR
Sbjct: 118 SNNIIHRDIKPENILV----SQSGITKLCDFGFARTLAAPGDIYTDYVATRWYR 167
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,603,738
Number of Sequences: 37866
Number of extensions: 895330
Number of successful extensions: 3903
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 326
Number of HSP's successfully gapped in prelim test: 382
Number of HSP's that attempted gapping in prelim test: 2934
Number of HSP's gapped (non-prelim): 866
length of query: 460
length of database: 18,247,518
effective HSP length: 106
effective length of query: 354
effective length of database: 14,233,722
effective search space: 5038737588
effective search space used: 5038737588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.