Search of human proteins with 110611228

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110611228 utrophin [Homo sapiens]
         (3433 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110611228 utrophin [Homo sapiens]                                 6777   0.0  
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                 1744   0.0  
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                  1743   0.0  
gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                  1740   0.0  
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]                 1643   0.0  
gi|5032285 dystrophin Dp427l isoform [Homo sapiens]                  1643   0.0  
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]                 1561   0.0  
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]               1558   0.0  
gi|5032293 dystrophin Dp140 isoform [Homo sapiens]                   1483   0.0  
gi|5032309 dystrophin Dp140b isoform [Homo sapiens]                  1481   0.0  
gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]                 1459   0.0  
gi|5032295 dystrophin Dp116 isoform [Homo sapiens]                   1270   0.0  
gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]                 1170   0.0  
gi|5032307 dystrophin Dp140c isoform [Homo sapiens]                  1153   0.0  
gi|5032297 dystrophin Dp71 isoform [Homo sapiens]                     892   0.0  
gi|5032299 dystrophin Dp71b isoform [Homo sapiens]                    890   0.0  
gi|148539558 dystrophin related protein 2 [Homo sapiens]              884   0.0  
gi|5032301 dystrophin Dp71a isoform [Homo sapiens]                    869   0.0  
gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]                   867   0.0  
gi|5032305 dystrophin Dp40 isoform [Homo sapiens]                     579   e-164
gi|33188443 microfilament and actin filament cross-linker protei...   315   4e-85
gi|33188445 microfilament and actin filament cross-linker protei...   315   4e-85
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...   290   2e-77
gi|67782321 spectrin beta isoform a [Homo sapiens]                    281   8e-75
gi|67782319 spectrin beta isoform b [Homo sapiens]                    281   8e-75
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        281   8e-75
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        280   2e-74
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       280   2e-74
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        279   4e-74
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        279   4e-74

>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score = 6777 bits (17582), Expect = 0.0
 Identities = 3433/3433 (100%), Positives = 3433/3433 (100%)

Query: 1    MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDL 60
            MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDL
Sbjct: 1    MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDL 60

Query: 61   KDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNH 120
            KDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNH
Sbjct: 61   KDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNH 120

Query: 121  KLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT 180
            KLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT
Sbjct: 121  KLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT 180

Query: 181  DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDK 240
            DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDK
Sbjct: 181  DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDK 240

Query: 241  KSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAET 300
            KSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAET
Sbjct: 241  KSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAET 300

Query: 301  PSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT 360
            PSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT
Sbjct: 301  PSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT 360

Query: 361  AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM 420
            AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM
Sbjct: 361  AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM 420

Query: 421  ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL 480
            ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL
Sbjct: 421  ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL 480

Query: 481  THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540
            THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL
Sbjct: 481  THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540

Query: 541  LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600
            LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL
Sbjct: 541  LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660
            LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE
Sbjct: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660

Query: 661  QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK 720
            QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK
Sbjct: 661  QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK 720

Query: 721  MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEW 780
            MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEW
Sbjct: 721  MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEW 780

Query: 781  KNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDS 840
            KNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDS
Sbjct: 781  KNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDS 840

Query: 841  CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL 900
            CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL
Sbjct: 841  CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL 900

Query: 901  ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ 960
            ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ
Sbjct: 901  ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ 960

Query: 961  KPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRA 1020
            KPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRA
Sbjct: 961  KPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRA 1020

Query: 1021 FEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE 1080
            FEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE
Sbjct: 1021 FEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE 1080

Query: 1081 TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEW 1140
            TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEW
Sbjct: 1081 TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEW 1140

Query: 1141 MTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGG 1200
            MTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGG
Sbjct: 1141 MTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGG 1200

Query: 1201 QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE 1260
            QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE
Sbjct: 1201 QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE 1260

Query: 1261 VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYED 1320
            VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYED
Sbjct: 1261 VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYED 1320

Query: 1321 LSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKI 1380
            LSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKI
Sbjct: 1321 LSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKI 1380

Query: 1381 QAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF 1440
            QAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF
Sbjct: 1381 QAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF 1440

Query: 1441 EQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGR 1500
            EQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGR
Sbjct: 1441 EQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGR 1500

Query: 1501 HIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWL 1560
            HIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWL
Sbjct: 1501 HIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWL 1560

Query: 1561 SATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEP 1620
            SATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEP
Sbjct: 1561 SATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEP 1620

Query: 1621 ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK 1680
            ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK
Sbjct: 1621 ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK 1680

Query: 1681 KPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKV 1740
            KPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKV
Sbjct: 1681 KPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKV 1740

Query: 1741 SQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE 1800
            SQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE
Sbjct: 1741 SQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE 1800

Query: 1801 KMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLA 1860
            KMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLA
Sbjct: 1801 KMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLA 1860

Query: 1861 SGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKL 1920
            SGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKL
Sbjct: 1861 SGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKL 1920

Query: 1921 GEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ 1980
            GEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ
Sbjct: 1921 GEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ 1980

Query: 1981 FHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGD 2040
            FHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGD
Sbjct: 1981 FHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGD 2040

Query: 2041 GIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWL 2100
            GIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWL
Sbjct: 2041 GIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWL 2100

Query: 2101 TKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKI 2160
            TKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKI
Sbjct: 2101 TKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKI 2160

Query: 2161 SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSH 2220
            SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSH
Sbjct: 2161 SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSH 2220

Query: 2221 RTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRH 2280
            RTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRH
Sbjct: 2221 RTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRH 2280

Query: 2281 PQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQ 2340
            PQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQ
Sbjct: 2281 PQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQ 2340

Query: 2341 WDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQK 2400
            WDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQK
Sbjct: 2341 WDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQK 2400

Query: 2401 LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQ 2460
            LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQ
Sbjct: 2401 LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQ 2460

Query: 2461 EAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKAL 2520
            EAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKAL
Sbjct: 2461 EAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKAL 2520

Query: 2521 GNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE 2580
            GNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE
Sbjct: 2521 GNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE 2580

Query: 2581 ELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRR 2640
            ELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRR
Sbjct: 2581 ELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRR 2640

Query: 2641 NLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAM 2700
            NLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAM
Sbjct: 2641 NLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAM 2700

Query: 2701 DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLS 2760
            DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLS
Sbjct: 2701 DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLS 2760

Query: 2761 PLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQR 2820
            PLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQR
Sbjct: 2761 PLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQR 2820

Query: 2821 SISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDL 2880
            SISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDL
Sbjct: 2821 SISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDL 2880

Query: 2881 LELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLL 2940
            LELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLL
Sbjct: 2881 LELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLL 2940

Query: 2941 NVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQ 3000
            NVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQ
Sbjct: 2941 NVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQ 3000

Query: 3001 IPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAA 3060
            IPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAA
Sbjct: 3001 IPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAA 3060

Query: 3061 AETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPT 3120
            AETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPT
Sbjct: 3061 AETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPT 3120

Query: 3121 TSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPS 3180
            TSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPS
Sbjct: 3121 TSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPS 3180

Query: 3181 QSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGES 3240
            QSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGES
Sbjct: 3181 QSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGES 3240

Query: 3241 PVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGLPVGSPPE 3300
            PVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGLPVGSPPE
Sbjct: 3241 PVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGLPVGSPPE 3300

Query: 3301 SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS 3360
            SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS
Sbjct: 3301 SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS 3360

Query: 3361 RINGVSPWASPQHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFP 3420
            RINGVSPWASPQHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFP
Sbjct: 3361 RINGVSPWASPQHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFP 3420

Query: 3421 SCCPNVPSRPQAM 3433
            SCCPNVPSRPQAM
Sbjct: 3421 SCCPNVPSRPQAM 3433


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score = 1744 bits (4517), Expect = 0.0
 Identities = 1059/2922 (36%), Positives = 1661/2922 (56%), Gaps = 260/2922 (8%)

Query: 26   SDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGST 85
            SDE  DVQKKTFTKW+NA+FSK GK  I ++F+DL+DGR+LLDLLEGLTG  LPKE+GST
Sbjct: 6    SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65

Query: 86   RVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMS 145
            RVHALNNVN+ L+VL  NNV+LVNIG TDIVDGNHKLTLGL+W+IILHWQVK+VMK++M+
Sbjct: 66   RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125

Query: 146  DLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVV-K 204
             LQQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W+ VV +
Sbjct: 126  GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185

Query: 205  MSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIR 264
             S  +RLEHAF+ A+  LGIEKLLDPEDV    PDKKSI+MY+TSLF+VLPQQV+I+AI+
Sbjct: 186  QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQ 245

Query: 265  EVETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA--------------- 298
            EVE LPR  K   EE           + I +      E   SP+                
Sbjct: 246  EVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTT 305

Query: 299  -------------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS 339
                         E P      S++ E +++LD YQ ALEEVL+WLLSAEDT Q Q +IS
Sbjct: 306  SDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS 365

Query: 340  DDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNA 399
            +DVE VKDQF THE +MM+LTAHQ  VG++LQ G++LI  G LS++EE E+QEQM LLN+
Sbjct: 366  NDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS 425

Query: 400  RWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKL 459
            RWE LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME  PL  D++ L++ 
Sbjct: 426  RWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 485

Query: 460  LEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEE 519
            +++HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW  +CRWTE+
Sbjct: 486  VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 545

Query: 520  RWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKED 579
            RW  LQ+I + WQ L EEQCL  AWL+EKE+A+NK+ T+ FKDQ E+  S+++LA+LK D
Sbjct: 546  RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 605

Query: 580  MEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAV 639
            +E K+Q++ +L  + QD+   L N   ++K  +  +   + WD+LVQ+LE S+ Q++QAV
Sbjct: 606  LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 665

Query: 640  --AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
               +  ++Q    + + TV  REQ + K +++ELPPPPP KKRQI VD E +K+ D    
Sbjct: 666  TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725

Query: 698  ELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVE 757
            EL +WI + +  +Q+ E   + K  + S++K+K+ A+E+E+ E+  +  + +++ Q LVE
Sbjct: 726  ELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVE 785

Query: 758  QMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTK 817
            QM  EG+  + IK   E+++S W    Q L +    ++ Q +I A++ QL +LE++  T 
Sbjct: 786  QMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTA 845

Query: 818  EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR 877
            E W+K    + S   ++ S    C+ E+  L GL P+IE  +    AL  +   P F+  
Sbjct: 846  ENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDA 905

Query: 878  GFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVL 937
             F +F   ++ V   V+ R++ L+      P   Y ET+  ++  +  SE K  +    +
Sbjct: 906  DFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 965

Query: 938  NDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKW 997
             D   +E+ L E + L   L+ Q+  L+ L+   K + K    ++ + Y+ EF++++G+W
Sbjct: 966  TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1025

Query: 998  NKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLD 1057
             KL   + +    LEE    LR  +     ++KWM  V  FL ++  A GD   L++QL 
Sbjct: 1026 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1085

Query: 1058 QCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQK 1117
            QC   V++I+TI+ SL ++ E    +++       + ++T L +  TQ + + +++  +K
Sbjct: 1086 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARK 1145

Query: 1118 SRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQ 1177
              L    EK  +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRAKE+  Q
Sbjct: 1146 EALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQ 1205

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWI 1236
            KE +VK+L +++  + A+ P   QE L  EL  +  NYQ LC R+ GKC TLEEVW+CW 
Sbjct: 1206 KEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWH 1265

Query: 1237 ELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQT 1296
            ELL YL+    WLN +E ++K+TE +P   + ++E L+SLE+++RH  DN  QIR L QT
Sbjct: 1266 ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT 1325

Query: 1297 LIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGEL 1356
            L DGG++D++I+E+LE FNSR+ +L   A  +Q  LE+ +Q  +ET++ L ++QESL  +
Sbjct: 1326 LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385

Query: 1357 DKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQ 1416
            DKQL  Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ +       +    R  SQ
Sbjct: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAAQRVLSQ 1439

Query: 1417 MDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLD 1476
            +DV Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK  L  L+ K V+ +V+Q+ L+
Sbjct: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499

Query: 1477 KCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGK 1536
             C+ LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA+VTE K
Sbjct: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559

Query: 1537 QDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEK 1596
            Q LE+  +L+RKM+KE   L+EWL+AT+ EL ++S  EG+  +LD+E++W K   K++EK
Sbjct: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619

Query: 1597 RKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
            +K  L +ITE   AL+ ++   E ++E++L +LN+ W  V +  E+W N L+ +Q  +E 
Sbjct: 1620 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1679

Query: 1657 FDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMN 1716
            FD NV HI+ W+ QA+ LLDE EKK   ++E+++KRL +EL+D   +V++ RDQA  LM 
Sbjct: 1680 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739

Query: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLE 1776
             RG   R+LVEP+++ELN  F  +S  IK+ K                     +P  +LE
Sbjct: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASIPLKELE 1780

Query: 1777 KLENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQPMEDNKK 1829
            +  +DI+ +L+ +E       +L+  D ++ M+E++   ++E+LQRG+ +  +  ++ K+
Sbjct: 1781 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKR 1840

Query: 1830 EKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS 1889
            E+I+++  LL T++N +K +  Q+RK       +  S     Y  + + +L C+DD+E  
Sbjct: 1841 EEIKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCLDDIEKK 1895

Query: 1890 L-NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948
            L ++PE            E  +K I  +L K  E++  +  +   +  + +   A+ +  
Sbjct: 1896 LASLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA---AMAVEP 1943

Query: 1949 TLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FHCDLNDL 1988
            T  QL+ +W  I   ++  +      +   R+                    +  ++  +
Sbjct: 1944 TQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHV 2003

Query: 1989 TQWITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL 2046
            +Q + E E+LL   D CA     DL K     + ++  +         ++      +Q  
Sbjct: 2004 SQALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062

Query: 2047 SQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHA 2106
            +  +   L+E L+ L+ +W+ +    KDRQ R     ++  ++ + +     WLT+AE  
Sbjct: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122

Query: 2107 MQKRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISES 2163
            ++K    E  E+ +    L++L   +      ++ LN T  E++   S +  +   + E 
Sbjct: 2123 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DASILQEK 2180

Query: 2164 LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTS 2223
            L ++N+ W ++C+++    K   ++ + +S+ +     ++ + VL    +D        +
Sbjct: 2181 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--------N 2228

Query: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
              SIP +  K            +Q LK  +      E++   V  + + +  L+Q +   
Sbjct: 2229 IASIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILKQLNE-- 2268

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
                T    L +   S + +  +  KL++   QW      +  +Q ++E  I D  Q + 
Sbjct: 2269 ----TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEK 2324

Query: 2344 HREETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDN 2396
              E+ EE +            +L I  Q  ++     + + +I +Q   P    +++   
Sbjct: 2325 KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEEILSKGQ 2383

Query: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQASRRDLE 2453
             L K         T+ VK   E L + W  +N L Q +  +Q  L     T+ AS     
Sbjct: 2384 HLYK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTV 2438

Query: 2454 NFL-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ------ 2491
              + + +   ET ++              L D +     L D  S+L + +K Q      
Sbjct: 2439 TLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGD 2498

Query: 2492 MQDIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDDMNQRWN 2541
            ++DI   I       + ++  R          Q +     N E  T++  R++ +  +W+
Sbjct: 2499 LEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2558

Query: 2542 DLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELKKQMPIG 2589
            +       ++ HL+   ++ N +   L++  +WL  K+E            E  K+ P  
Sbjct: 2559 E-------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPY- 2607

Query: 2590 GDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELT 2649
              V A+Q +    K L ++L++ + +V  A D A   L D       +  R +   T   
Sbjct: 2608 -TVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVHMIT--- 2659

Query: 2650 PEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL-DADMK 2708
              E      +++ K+ SE +   E  + +   +   ++K L  L + +   + L DA  K
Sbjct: 2660 --ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717

Query: 2709 E-----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFKVKTVND 2754
            E     ++ V+   K   DL         +  +L ++ +KI+   E         + +++
Sbjct: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 2777

Query: 2755 LSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796
            ++ + S L    SL +   L+  + +WK L +S+ + L  LQ
Sbjct: 2778 MNFKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2818



 Score = 1643 bits (4254), Expect = 0.0
 Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)

Query: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356
            E  S +  V MDL + +  L+E+  WL   E+  +  E++ +  D+E++K Q   H+   
Sbjct: 436  EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 493

Query: 357  MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416
             +L   Q  V S+      ++   +  D     ++EQ+ +L  RW  +   + DR   L 
Sbjct: 494  EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 551

Query: 417  DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471
            D+L++ Q+   +Q   SAWL+  E+ + K+ T    D    + SLQKL      L++DLE
Sbjct: 552  DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 607

Query: 472  AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
             ++  +  L  +   ++     +S T   E  L      W  + +  E+   ++ +    
Sbjct: 608  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667

Query: 531  WQELL--------------EEQCLLK---------------------------------- 542
             Q  L               EQ L+K                                  
Sbjct: 668  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727

Query: 543  -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600
             +W+T  E  L   + + F+ +   S    ++  ++ +   K + L   S   Q  V Q+
Sbjct: 728  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656
            ++    +  I   SE+L  RW    Q L +  N +      +   +Q+ Q + + T    
Sbjct: 788  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 847

Query: 657  -------------------------------------RVREQAITKKSKQELPP------ 673
                                                 R++ Q+I  K K + P       
Sbjct: 848  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907

Query: 674  -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723
                   +Q+  D++A++K     FD +      E ++ I  W    +T      + + D
Sbjct: 908  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 967

Query: 724  TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777
               M+++L   +AL+   +E+      L+ T    V++M K+  P+E   + ++  E++ 
Sbjct: 968  YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 1022

Query: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
              WK +S  L  +E   +L+E +N    +L +++  I+T ++W+    +    ++  P+L
Sbjct: 1023 GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 1074

Query: 838  KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885
             DS         C+  ++++  + P +         + ++ + P+F  R          +
Sbjct: 1075 GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1133

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939
            +  + + V  R++ L+  L+        +T+   KD+    E   Q     L        
Sbjct: 1134 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1185

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
              +++KA++E K   E  + ++  +  L E   ++     P  ++  K+E + +   +  
Sbjct: 1186 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1245

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L   ++     LEE+        +      KW++ V+  L   +   G    +   LD  
Sbjct: 1246 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1305

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
                N +   E +   ++ +   L  G V  +   +   L  + ++  +L +E   ++  
Sbjct: 1306 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1360

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1361 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1415

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1416 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1468

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1469 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1523

Query: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1584 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639

Query: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1640 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699

Query: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1759

Query: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1760 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1818

Query: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1819 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1878

Query: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1879 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1929

Query: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1930 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1981

Query: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1982 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2039

Query: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 2040 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2099

Query: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 2100 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2153

Query: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 2154 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2213

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 2214 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2272

Query: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2273 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2332

Query: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2333 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2389

Query: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2390 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2449

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2450 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2506

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2507 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2566

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2567 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2626

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2627 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2686

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2687 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2746

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2747 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2806

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2807 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2866

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2867 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2923

Query: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2924 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2983

Query: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2984 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 3043

Query: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 3044 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 3103

Query: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 3104 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3163

Query: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 3164 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3223

Query: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 3224 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3283

Query: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3284 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3343

Query: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3344 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3403

Query: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3404 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3463

Query: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3464 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3523

Query: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3524 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3583

Query: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3584 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3643

Query: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3644 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3675



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 1909 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1968

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 1969 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 2025

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 2026 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2083

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 2084 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2141

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 2142 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2199

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 2200 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2257

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 2258 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 2315 QIKDLGQLEKKLEDL--------------------------------------------E 2330

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 2331 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2386

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 2387 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2439

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 2440 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2499

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 2500 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2559

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 2560 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2617

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 2618 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2677

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2736

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 2737 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2796

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 2797 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2855

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 2856 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2915

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 2916 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2964

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 2965 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 3001



 Score =  102 bits (255), Expect = 5e-21
 Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)

Query: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
            S  E  ++++ +  LN++W+ +     +++    R + + +  +  L +L  W+T+ EE 
Sbjct: 409  SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 466

Query: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
               ++    G  L+  K ++ Q + L+  +   Q    +L      + +       + L+
Sbjct: 467  TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 526

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113
            E+L  L  RW  I    +DR   L+    +  +   +      WL++ E A+ K  TT  
Sbjct: 527  EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 586

Query: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166
                E+  +LQ+L  L  ++E   +   KL  L +  L  L +KS++     K    L  
Sbjct: 587  KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 642

Query: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215
                W+ + +++  +  +  Q  +    S++QT +         ++ +LV  A +     
Sbjct: 643  FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 702

Query: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269
            P Q  R  T +  I   LD  ITEL  W+   + +L+S    +    G+  ++ + V+ +
Sbjct: 703  PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 762

Query: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318
            +  KA+  ++          L + + N+  ++D     +E+L             +  W 
Sbjct: 763  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 822

Query: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370
              Q+ +     + QQLE M   +  W   +  T       +++L I +      +   P 
Sbjct: 823  EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 882

Query: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426
             +++    I L+E G G    D   +AF N  +++     SD     KE           
Sbjct: 883  IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 928

Query: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486
              Q+I D    +  +  T+ A R        W+Q++ET +++       + ++ D  +  
Sbjct: 929  --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 972

Query: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546
            +   ++Q +Q+ +         +    ++M K    SE +   Q   +++  RW  L ++
Sbjct: 973  QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 1031

Query: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606
                   LE    K  ++   ++ L KW+   D  LK++ P  GD   L+ Q   C+ L 
Sbjct: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091

Query: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
             +++  + S LN+V++       Q I+   EP    + +TEL                  
Sbjct: 1092 SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1128

Query: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726
            E+  +W+ +       ++ +   LEK   LQ  + ++   M +AE      +       D
Sbjct: 1129 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1187

Query: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
             LQ  +E++   +EE      KVK    +VN + +Q  P+       + ++L+ L   ++
Sbjct: 1188 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1244

Query: 2783 LLQVSVDDRLKQLQE 2797
             L   ++ + K L+E
Sbjct: 1245 WLCTRLNGKCKTLEE 1259



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 2674 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2733

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 2734 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2792

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 2793 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2850

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 3021

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 3022 LLQVAVEDRVRQLHEAHRDFG 3042



 Score = 38.9 bits (89), Expect = 0.089
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
            S  + L  S    +R   +LEE++ WL   ++ L+ Q  I  DV  ++ Q+   +    +
Sbjct: 325  SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384

Query: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
            L   +  V N +      +    +   EE                       +++Q + +
Sbjct: 385  LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 423

Query: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723
              +WE L   +   Q  + + L     +KL++L   +   +   ++ E      +P+G  
Sbjct: 424  NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 478

Query: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779
            L D L+  +++    +E++     +   VN L+  +  +D     H +  +  QL  L  
Sbjct: 479  LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 534

Query: 2780 RWKLLQVSVDDRLKQLQE 2797
            RW  +    +DR   LQ+
Sbjct: 535  RWANICRWTEDRWVLLQD 552



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 2850 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2907

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 2908 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2967

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 2968 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 3024

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 3025 VAVEDRVRQLHE 3036


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score = 1743 bits (4513), Expect = 0.0
 Identities = 1058/2921 (36%), Positives = 1660/2921 (56%), Gaps = 260/2921 (8%)

Query: 27   DEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTR 86
            DE  DVQKKTFTKW+NA+FSK GK  I ++F+DL+DGR+LLDLLEGLTG  LPKE+GSTR
Sbjct: 3    DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 62

Query: 87   VHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSD 146
            VHALNNVN+ L+VL  NNV+LVNIG TDIVDGNHKLTLGL+W+IILHWQVK+VMK++M+ 
Sbjct: 63   VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 122

Query: 147  LQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVV-KM 205
            LQQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W+ VV + 
Sbjct: 123  LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 182

Query: 206  SPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIRE 265
            S  +RLEHAF+ A+  LGIEKLLDPEDV    PDKKSI+MY+TSLF+VLPQQV+I+AI+E
Sbjct: 183  SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQE 242

Query: 266  VETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA---------------- 298
            VE LPR  K   EE           + I +      E   SP+                 
Sbjct: 243  VEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTS 302

Query: 299  ------------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISD 340
                        E P      S++ E +++LD YQ ALEEVL+WLLSAEDT Q Q +IS+
Sbjct: 303  DPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISN 362

Query: 341  DVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNAR 400
            DVE VKDQF THE +MM+LTAHQ  VG++LQ G++LI  G LS++EE E+QEQM LLN+R
Sbjct: 363  DVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSR 422

Query: 401  WEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLL 460
            WE LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME  PL  D++ L++ +
Sbjct: 423  WECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQV 482

Query: 461  EEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEER 520
            ++HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW  +CRWTE+R
Sbjct: 483  QQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDR 542

Query: 521  WNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDM 580
            W  LQ+I + WQ L EEQCL  AWL+EKE+A+NK+ T+ FKDQ E+  S+++LA+LK D+
Sbjct: 543  WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL 602

Query: 581  EMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAV- 639
            E K+Q++ +L  + QD+   L N   ++K  +  +   + WD+LVQ+LE S+ Q++QAV 
Sbjct: 603  EKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVT 662

Query: 640  -AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAE 698
              +  ++Q    + + TV  REQ + K +++ELPPPPP KKRQI VD E +K+ D    E
Sbjct: 663  TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITE 722

Query: 699  LLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQ 758
            L +WI + +  +Q+ E   + K  + S++K+K+ A+E+E+ E+  +  + +++ Q LVEQ
Sbjct: 723  LHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQ 782

Query: 759  MGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKE 818
            M  EG+  + IK   E+++S W    Q L +    ++ Q +I A++ QL +LE++  T E
Sbjct: 783  MVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAE 842

Query: 819  EWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRG 878
             W+K    + S   ++ S    C+ E+  L GL P+IE  +    AL  +   P F+   
Sbjct: 843  NWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD 902

Query: 879  FDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN 938
            F +F   ++ V   V+ R++ L+      P   Y ET+  ++  +  SE K  +    + 
Sbjct: 903  FVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVT 962

Query: 939  DLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWN 998
            D   +E+ L E + L   L+ Q+  L+ L+   K + K    ++ + Y+ EF++++G+W 
Sbjct: 963  DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK 1022

Query: 999  KLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQ 1058
            KL   + +    LEE    LR  +     ++KWM  V  FL ++  A GD   L++QL Q
Sbjct: 1023 KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ 1082

Query: 1059 CSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKS 1118
            C   V++I+TI+ SL ++ E    +++       + ++T L +  TQ + + +++  +K 
Sbjct: 1083 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1142

Query: 1119 RLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQK 1178
             L    EK  +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRAKE+  QK
Sbjct: 1143 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1202

Query: 1179 EVRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIE 1237
            E +VK+L +++  + A+ P   QE L  EL  +  NYQ LC R+ GKC TLEEVW+CW E
Sbjct: 1203 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE 1262

Query: 1238 LLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTL 1297
            LL YL+    WLN +E ++K+TE +P   + ++E L+SLE+++RH  DN  QIR L QTL
Sbjct: 1263 LLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTL 1322

Query: 1298 IDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELD 1357
             DGG++D++I+E+LE FNSR+ +L   A  +Q  LE+ +Q  +ET++ L ++QESL  +D
Sbjct: 1323 TDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFID 1382

Query: 1358 KQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQM 1417
            KQL  Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ +       +    R  SQ+
Sbjct: 1383 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAAQRVLSQI 1436

Query: 1418 DVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDK 1477
            DV Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK  L  L+ K V+ +V+Q+ L+ 
Sbjct: 1437 DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH 1496

Query: 1478 CMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQ 1537
            C+ LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA+VTE KQ
Sbjct: 1497 CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 1556

Query: 1538 DLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKR 1597
             LE+  +L+RKM+KE   L+EWL+AT+ EL ++S  EG+  +LD+E++W K   K++EK+
Sbjct: 1557 QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 1616

Query: 1598 KADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIF 1657
            K  L +ITE   AL+ ++   E ++E++L +LN+ W  V +  E+W N L+ +Q  +E F
Sbjct: 1617 KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETF 1676

Query: 1658 DGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNA 1717
            D NV HI+ W+ QA+ LLDE EKK   ++E+++KRL +EL+D   +V++ RDQA  LM  
Sbjct: 1677 DQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN 1736

Query: 1718 RGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEK 1777
            RG   R+LVEP+++ELN  F  +S  IK+ K                     +P  +LE+
Sbjct: 1737 RGDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASIPLKELEQ 1777

Query: 1778 LENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQPMEDNKKE 1830
              +DI+ +L+ +E       +L+  D ++ M+E++   ++E+LQRG+ +  +  ++ K+E
Sbjct: 1778 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1837

Query: 1831 KIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL 1890
            +I+++  LL T++N +K +  Q+RK       +  S     Y  + + +L C+DD+E  L
Sbjct: 1838 EIKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCLDDIEKKL 1892

Query: 1891 -NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDT 1949
             ++PE            E  +K I  +L K  E++  +  +   +  + +   A+ +  T
Sbjct: 1893 ASLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA---AMAVEPT 1940

Query: 1950 LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FHCDLNDLT 1989
              QL+ +W  I   ++  +      +   R+                    +  ++  ++
Sbjct: 1941 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 2000

Query: 1990 QWITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLS 2047
            Q + E E+LL   D CA     DL K     + ++  +         ++      +Q  +
Sbjct: 2001 QALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSAT 2059

Query: 2048 QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAM 2107
              +   L+E L+ L+ +W+ +    KDRQ R     ++  ++ + +     WLT+AE  +
Sbjct: 2060 PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 2119

Query: 2108 QKRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESL 2164
            +K    E  E+ +    L++L   +      ++ LN T  E++   S +  +   + E L
Sbjct: 2120 RKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DASILQEKL 2177

Query: 2165 RTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSE 2224
             ++N+ W ++C+++    K   ++ + +S+ +     ++ + VL    +D        + 
Sbjct: 2178 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--------NI 2225

Query: 2225 ISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLD 2284
             SIP +  K            +Q LK  +      E++   V  + + +  L+Q +    
Sbjct: 2226 ASIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILKQLNE--- 2264

Query: 2285 YVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDH 2344
               T    L +   S + +  +  KL++   QW      +  +Q ++E  I D  Q +  
Sbjct: 2265 ---TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKK 2321

Query: 2345 REETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNV 2397
             E+ EE +            +L I  Q  ++     + + +I +Q   P    +++    
Sbjct: 2322 LEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEEILSKGQH 2380

Query: 2398 LQKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQASRRDLEN 2454
            L K         T+ VK   E L + W  +N L Q +  +Q  L     T+ AS      
Sbjct: 2381 LYK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2435

Query: 2455 FL-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ------M 2492
             + + +   ET ++              L D +     L D  S+L + +K Q      +
Sbjct: 2436 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2495

Query: 2493 QDIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDDMNQRWND 2542
            +DI   I       + ++  R          Q +     N E  T++  R++ +  +W++
Sbjct: 2496 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2555

Query: 2543 LKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELKKQMPIGG 2590
                   ++ HL+   ++ N +   L++  +WL  K+E            E  K+ P   
Sbjct: 2556 -------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPY-- 2603

Query: 2591 DVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTP 2650
             V A+Q +    K L ++L++ + +V  A D A   L D       +  R +   T    
Sbjct: 2604 TVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVHMIT---- 2655

Query: 2651 EERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL-DADMKE 2709
             E      +++ K+ SE +   E  + +   +   ++K L  L + +   + L DA  KE
Sbjct: 2656 -ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2714

Query: 2710 -----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFKVKTVNDL 2755
                 ++ V+   K   DL         +  +L ++ +KI+   E         + ++++
Sbjct: 2715 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2774

Query: 2756 SSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796
            + + S L    SL +   L+  + +WK L +S+ + L  LQ
Sbjct: 2775 NFKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2814



 Score = 1643 bits (4254), Expect = 0.0
 Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)

Query: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356
            E  S +  V MDL + +  L+E+  WL   E+  +  E++ +  D+E++K Q   H+   
Sbjct: 432  EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 489

Query: 357  MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416
             +L   Q  V S+      ++   +  D     ++EQ+ +L  RW  +   + DR   L 
Sbjct: 490  EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 547

Query: 417  DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471
            D+L++ Q+   +Q   SAWL+  E+ + K+ T    D    + SLQKL      L++DLE
Sbjct: 548  DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 603

Query: 472  AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
             ++  +  L  +   ++     +S T   E  L      W  + +  E+   ++ +    
Sbjct: 604  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 663

Query: 531  WQELL--------------EEQCLLK---------------------------------- 542
             Q  L               EQ L+K                                  
Sbjct: 664  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 723

Query: 543  -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600
             +W+T  E  L   + + F+ +   S    ++  ++ +   K + L   S   Q  V Q+
Sbjct: 724  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 783

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656
            ++    +  I   SE+L  RW    Q L +  N +      +   +Q+ Q + + T    
Sbjct: 784  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 843

Query: 657  -------------------------------------RVREQAITKKSKQELPP------ 673
                                                 R++ Q+I  K K + P       
Sbjct: 844  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 903

Query: 674  -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723
                   +Q+  D++A++K     FD +      E ++ I  W    +T      + + D
Sbjct: 904  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 963

Query: 724  TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777
               M+++L   +AL+   +E+      L+ T    V++M K+  P+E   + ++  E++ 
Sbjct: 964  YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 1018

Query: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
              WK +S  L  +E   +L+E +N    +L +++  I+T ++W+    +    ++  P+L
Sbjct: 1019 GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 1070

Query: 838  KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885
             DS         C+  ++++  + P +         + ++ + P+F  R          +
Sbjct: 1071 GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1129

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939
            +  + + V  R++ L+  L+        +T+   KD+    E   Q     L        
Sbjct: 1130 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1181

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
              +++KA++E K   E  + ++  +  L E   ++     P  ++  K+E + +   +  
Sbjct: 1182 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1241

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L   ++     LEE+        +      KW++ V+  L   +   G    +   LD  
Sbjct: 1242 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1301

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
                N +   E +   ++ +   L  G V  +   +   L  + ++  +L +E   ++  
Sbjct: 1302 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1356

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1357 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1411

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1412 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1464

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1465 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1519

Query: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1580 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1635

Query: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1636 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1695

Query: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1696 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1755

Query: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1756 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1814

Query: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1815 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1874

Query: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1875 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1925

Query: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1926 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1977

Query: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1978 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2035

Query: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 2036 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2095

Query: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 2096 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2149

Query: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 2150 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2209

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 2210 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2268

Query: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2269 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2328

Query: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2329 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2385

Query: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2386 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2445

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2446 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2502

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2503 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2562

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2563 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2622

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2623 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2682

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2683 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2742

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2743 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2802

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2803 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2862

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2863 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2919

Query: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2920 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2979

Query: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2980 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 3039

Query: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 3040 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 3099

Query: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 3100 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3159

Query: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 3160 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3219

Query: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 3220 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3279

Query: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3280 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3339

Query: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3340 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3399

Query: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3400 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3459

Query: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3460 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3519

Query: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3520 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3579

Query: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3580 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3639

Query: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3640 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3671



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 1905 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1964

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 1965 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 2021

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 2022 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2079

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 2080 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2137

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 2138 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2195

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 2196 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2253

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 2254 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2310

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 2311 QIKDLGQLEKKLEDL--------------------------------------------E 2326

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 2327 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2382

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 2383 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2435

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 2436 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2495

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 2496 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2555

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 2556 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2613

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 2614 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2673

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 2674 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2732

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 2733 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2792

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 2793 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2851

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 2852 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2911

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 2912 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2960

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 2961 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 2997



 Score =  102 bits (255), Expect = 5e-21
 Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)

Query: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
            S  E  ++++ +  LN++W+ +     +++    R + + +  +  L +L  W+T+ EE 
Sbjct: 405  SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 462

Query: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
               ++    G  L+  K ++ Q + L+  +   Q    +L      + +       + L+
Sbjct: 463  TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 522

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113
            E+L  L  RW  I    +DR   L+    +  +   +      WL++ E A+ K  TT  
Sbjct: 523  EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 582

Query: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166
                E+  +LQ+L  L  ++E   +   KL  L +  L  L +KS++     K    L  
Sbjct: 583  KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 638

Query: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215
                W+ + +++  +  +  Q  +    S++QT +         ++ +LV  A +     
Sbjct: 639  FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 698

Query: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269
            P Q  R  T +  I   LD  ITEL  W+   + +L+S    +    G+  ++ + V+ +
Sbjct: 699  PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 758

Query: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318
            +  KA+  ++          L + + N+  ++D     +E+L             +  W 
Sbjct: 759  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 818

Query: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370
              Q+ +     + QQLE M   +  W   +  T       +++L I +      +   P 
Sbjct: 819  EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 878

Query: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426
             +++    I L+E G G    D   +AF N  +++     SD     KE           
Sbjct: 879  IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 924

Query: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486
              Q+I D    +  +  T+ A R        W+Q++ET +++       + ++ D  +  
Sbjct: 925  --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 968

Query: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546
            +   ++Q +Q+ +         +    ++M K    SE +   Q   +++  RW  L ++
Sbjct: 969  QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 1027

Query: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606
                   LE    K  ++   ++ L KW+   D  LK++ P  GD   L+ Q   C+ L 
Sbjct: 1028 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1087

Query: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
             +++  + S LN+V++       Q I+   EP    + +TEL                  
Sbjct: 1088 SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1124

Query: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726
            E+  +W+ +       ++ +   LEK   LQ  + ++   M +AE      +       D
Sbjct: 1125 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1183

Query: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
             LQ  +E++   +EE      KVK    +VN + +Q  P+       + ++L+ L   ++
Sbjct: 1184 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1240

Query: 2783 LLQVSVDDRLKQLQE 2797
             L   ++ + K L+E
Sbjct: 1241 WLCTRLNGKCKTLEE 1255



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 2670 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2729

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 2730 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2788

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 2789 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2846

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 2847 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2906

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 2907 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2966

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 3017

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 3018 LLQVAVEDRVRQLHEAHRDFG 3038



 Score = 38.9 bits (89), Expect = 0.089
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
            S  + L  S    +R   +LEE++ WL   ++ L+ Q  I  DV  ++ Q+   +    +
Sbjct: 321  SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 380

Query: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
            L   +  V N +      +    +   EE                       +++Q + +
Sbjct: 381  LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 419

Query: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723
              +WE L   +   Q  + + L     +KL++L   +   +   ++ E      +P+G  
Sbjct: 420  NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 474

Query: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779
            L D L+  +++    +E++     +   VN L+  +  +D     H +  +  QL  L  
Sbjct: 475  LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 530

Query: 2780 RWKLLQVSVDDRLKQLQE 2797
            RW  +    +DR   LQ+
Sbjct: 531  RWANICRWTEDRWVLLQD 548



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 2846 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2903

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 2904 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2963

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 2964 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 3020

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 3021 VAVEDRVRQLHE 3032


>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
          Length = 3685

 Score = 1740 bits (4507), Expect = 0.0
 Identities = 1057/2920 (36%), Positives = 1659/2920 (56%), Gaps = 260/2920 (8%)

Query: 28   EHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRV 87
            E  DVQKKTFTKW+NA+FSK GK  I ++F+DL+DGR+LLDLLEGLTG  LPKE+GSTRV
Sbjct: 12   EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71

Query: 88   HALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDL 147
            HALNNVN+ L+VL  NNV+LVNIG TDIVDGNHKLTLGL+W+IILHWQVK+VMK++M+ L
Sbjct: 72   HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131

Query: 148  QQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVV-KMS 206
            QQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W+ VV + S
Sbjct: 132  QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191

Query: 207  PIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREV 266
              +RLEHAF+ A+  LGIEKLLDPEDV    PDKKSI+MY+TSLF+VLPQQV+I+AI+EV
Sbjct: 192  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 251

Query: 267  ETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA----------------- 298
            E LPR  K   EE           + I +      E   SP+                  
Sbjct: 252  EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 311

Query: 299  -----------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDD 341
                       E P      S++ E +++LD YQ ALEEVL+WLLSAEDT Q Q +IS+D
Sbjct: 312  PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 371

Query: 342  VEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARW 401
            VE VKDQF THE +MM+LTAHQ  VG++LQ G++LI  G LS++EE E+QEQM LLN+RW
Sbjct: 372  VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 431

Query: 402  EALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            E LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME  PL  D++ L++ ++
Sbjct: 432  ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 491

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
            +HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW  +CRWTE+RW
Sbjct: 492  QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 551

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
              LQ+I + WQ L EEQCL  AWL+EKE+A+NK+ T+ FKDQ E+  S+++LA+LK D+E
Sbjct: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAV-- 639
             K+Q++ +L  + QD+   L N   ++K  +  +   + WD+LVQ+LE S+ Q++QAV  
Sbjct: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671

Query: 640  AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAEL 699
             +  ++Q    + + TV  REQ + K +++ELPPPPP KKRQI VD E +K+ D    EL
Sbjct: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731

Query: 700  LNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQM 759
             +WI + +  +Q+ E   + K  + S++K+K+ A+E+E+ E+  +  + +++ Q LVEQM
Sbjct: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791

Query: 760  GKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEE 819
              EG+  + IK   E+++S W    Q L +    ++ Q +I A++ QL +LE++  T E 
Sbjct: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851

Query: 820  WVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGF 879
            W+K    + S   ++ S    C+ E+  L GL P+IE  +    AL  +   P F+   F
Sbjct: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911

Query: 880  DSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLND 939
             +F   ++ V   V+ R++ L+      P   Y ET+  ++  +  SE K  +    + D
Sbjct: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
               +E+ L E + L   L+ Q+  L+ L+   K + K    ++ + Y+ EF++++G+W K
Sbjct: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L   + +    LEE    LR  +     ++KWM  V  FL ++  A GD   L++QL QC
Sbjct: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
               V++I+TI+ SL ++ E    +++       + ++T L +  TQ + + +++  +K  
Sbjct: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKE 1179
            L    EK  +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRAKE+  QKE
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211

Query: 1180 VRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL 1238
             +VK+L +++  + A+ P   QE L  EL  +  NYQ LC R+ GKC TLEEVW+CW EL
Sbjct: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            L YL+    WLN +E ++K+TE +P   + ++E L+SLE+++RH  DN  QIR L QTL 
Sbjct: 1272 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1331

Query: 1299 DGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDK 1358
            DGG++D++I+E+LE FNSR+ +L   A  +Q  LE+ +Q  +ET++ L ++QESL  +DK
Sbjct: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391

Query: 1359 QLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMD 1418
            QL  Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ +       +    R  SQ+D
Sbjct: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAAQRVLSQID 1445

Query: 1419 VLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKC 1478
            V Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK  L  L+ K V+ +V+Q+ L+ C
Sbjct: 1446 VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHC 1505

Query: 1479 MKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQD 1538
            + LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA+VTE KQ 
Sbjct: 1506 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQ 1565

Query: 1539 LERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRK 1598
            LE+  +L+RKM+KE   L+EWL+AT+ EL ++S  EG+  +LD+E++W K   K++EK+K
Sbjct: 1566 LEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQK 1625

Query: 1599 ADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFD 1658
              L +ITE   AL+ ++   E ++E++L +LN+ W  V +  E+W N L+ +Q  +E FD
Sbjct: 1626 VHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685

Query: 1659 GNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNAR 1718
             NV HI+ W+ QA+ LLDE EKK   ++E+++KRL +EL+D   +V++ RDQA  LM  R
Sbjct: 1686 QNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANR 1745

Query: 1719 GSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKL 1778
            G   R+LVEP+++ELN  F  +S  IK+ K                     +P  +LE+ 
Sbjct: 1746 GDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASIPLKELEQF 1786

Query: 1779 ENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQPMEDNKKEK 1831
             +DI+ +L+ +E       +L+  D ++ M+E++   ++E+LQRG+ +  +  ++ K+E+
Sbjct: 1787 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1846

Query: 1832 IRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL- 1890
            I+++  LL T++N +K +  Q+RK       +  S     Y  + + +L C+DD+E  L 
Sbjct: 1847 IKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCLDDIEKKLA 1901

Query: 1891 NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTL 1950
            ++PE            E  +K I  +L K  E++  +  +   +  + +   A+ +  T 
Sbjct: 1902 SLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA---AMAVEPTQ 1949

Query: 1951 TQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FHCDLNDLTQ 1990
             QL+ +W  I   ++  +      +   R+                    +  ++  ++Q
Sbjct: 1950 IQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ 2009

Query: 1991 WITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048
             + E E+LL   D CA     DL K     + ++  +         ++      +Q  + 
Sbjct: 2010 ALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 2068

Query: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108
             +   L+E L+ L+ +W+ +    KDRQ R     ++  ++ + +     WLT+AE  ++
Sbjct: 2069 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 2128

Query: 2109 KRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLR 2165
            K    E  E+ +    L++L   +      ++ LN T  E++   S +  +   + E L 
Sbjct: 2129 KTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DASILQEKLG 2186

Query: 2166 TVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEI 2225
            ++N+ W ++C+++    K   ++ + +S+ +     ++ + VL    +D        +  
Sbjct: 2187 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--------NIA 2234

Query: 2226 SIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDY 2285
            SIP +  K            +Q LK  +      E++   V  + + +  L+Q +     
Sbjct: 2235 SIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILKQLNE---- 2272

Query: 2286 VFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHR 2345
              T    L +   S + +  +  KL++   QW      +  +Q ++E  I D  Q +   
Sbjct: 2273 --TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2330

Query: 2346 EETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVL 2398
            E+ EE +            +L I  Q  ++     + + +I +Q   P    +++    L
Sbjct: 2331 EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEEILSKGQHL 2389

Query: 2399 QKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQASRRDLENF 2455
             K         T+ VK   E L + W  +N L Q +  +Q  L     T+ AS       
Sbjct: 2390 YK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 2444

Query: 2456 L-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ------MQ 2493
            + + +   ET ++              L D +     L D  S+L + +K Q      ++
Sbjct: 2445 VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 2504

Query: 2494 DIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDDMNQRWNDL 2543
            DI   I       + ++  R          Q +     N E  T++  R++ +  +W++ 
Sbjct: 2505 DINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE- 2563

Query: 2544 KAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELKKQMPIGGD 2591
                  ++ HL+   ++ N +   L++  +WL  K+E            E  K+ P    
Sbjct: 2564 ------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPY--T 2612

Query: 2592 VPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPE 2651
            V A+Q +    K L ++L++ + +V  A D A   L D       +  R +   T     
Sbjct: 2613 VDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVHMIT----- 2663

Query: 2652 ERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL-DADMKE- 2709
            E      +++ K+ SE +   E  + +   +   ++K L  L + +   + L DA  KE 
Sbjct: 2664 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2723

Query: 2710 ----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLS 2756
                ++ V+   K   DL         +  +L ++ +KI+   E         + +++++
Sbjct: 2724 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2783

Query: 2757 SQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796
             + S L    SL +   L+  + +WK L +S+ + L  LQ
Sbjct: 2784 FKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2822



 Score = 1643 bits (4254), Expect = 0.0
 Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)

Query: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356
            E  S +  V MDL + +  L+E+  WL   E+  +  E++ +  D+E++K Q   H+   
Sbjct: 440  EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 497

Query: 357  MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416
             +L   Q  V S+      ++   +  D     ++EQ+ +L  RW  +   + DR   L 
Sbjct: 498  EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 555

Query: 417  DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471
            D+L++ Q+   +Q   SAWL+  E+ + K+ T    D    + SLQKL      L++DLE
Sbjct: 556  DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 611

Query: 472  AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
             ++  +  L  +   ++     +S T   E  L      W  + +  E+   ++ +    
Sbjct: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671

Query: 531  WQELL--------------EEQCLLK---------------------------------- 542
             Q  L               EQ L+K                                  
Sbjct: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731

Query: 543  -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600
             +W+T  E  L   + + F+ +   S    ++  ++ +   K + L   S   Q  V Q+
Sbjct: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656
            ++    +  I   SE+L  RW    Q L +  N +      +   +Q+ Q + + T    
Sbjct: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851

Query: 657  -------------------------------------RVREQAITKKSKQELPP------ 673
                                                 R++ Q+I  K K + P       
Sbjct: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911

Query: 674  -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723
                   +Q+  D++A++K     FD +      E ++ I  W    +T      + + D
Sbjct: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971

Query: 724  TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777
               M+++L   +AL+   +E+      L+ T    V++M K+  P+E   + ++  E++ 
Sbjct: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 1026

Query: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
              WK +S  L  +E   +L+E +N    +L +++  I+T ++W+    +    ++  P+L
Sbjct: 1027 GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 1078

Query: 838  KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885
             DS         C+  ++++  + P +         + ++ + P+F  R          +
Sbjct: 1079 GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1137

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939
            +  + + V  R++ L+  L+        +T+   KD+    E   Q     L        
Sbjct: 1138 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1189

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
              +++KA++E K   E  + ++  +  L E   ++     P  ++  K+E + +   +  
Sbjct: 1190 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1249

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L   ++     LEE+        +      KW++ V+  L   +   G    +   LD  
Sbjct: 1250 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1309

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
                N +   E +   ++ +   L  G V  +   +   L  + ++  +L +E   ++  
Sbjct: 1310 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1364

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1365 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1419

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1420 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1472

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1473 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1527

Query: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1588 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1643

Query: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1644 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703

Query: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1763

Query: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1764 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1822

Query: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1823 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1882

Query: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1883 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1933

Query: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1934 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1985

Query: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1986 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2043

Query: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 2044 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2103

Query: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 2104 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2157

Query: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 2158 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2217

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 2218 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2276

Query: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2277 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2336

Query: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2337 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2393

Query: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2394 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2453

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2454 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2510

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2511 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2570

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2571 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2630

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2631 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2690

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2691 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2750

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2751 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2810

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2811 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2870

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2871 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2927

Query: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2928 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2987

Query: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2988 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 3047

Query: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 3048 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 3107

Query: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 3108 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3167

Query: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 3168 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3227

Query: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 3228 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3287

Query: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3288 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3347

Query: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3348 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3407

Query: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3408 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3467

Query: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3468 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3527

Query: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3528 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3587

Query: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3588 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3647

Query: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3648 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3679



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 1913 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1972

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 1973 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 2029

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 2030 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2087

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 2088 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2145

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 2146 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2203

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 2204 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2261

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 2262 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 2319 QIKDLGQLEKKLEDL--------------------------------------------E 2334

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 2335 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2390

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 2391 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2443

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 2444 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2503

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 2504 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2563

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 2564 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2621

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 2622 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2681

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2740

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 2741 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2800

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 2801 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2859

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 2860 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2919

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 2920 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2968

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 2969 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 3005



 Score =  102 bits (255), Expect = 5e-21
 Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)

Query: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
            S  E  ++++ +  LN++W+ +     +++    R + + +  +  L +L  W+T+ EE 
Sbjct: 413  SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 470

Query: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
               ++    G  L+  K ++ Q + L+  +   Q    +L      + +       + L+
Sbjct: 471  TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 530

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113
            E+L  L  RW  I    +DR   L+    +  +   +      WL++ E A+ K  TT  
Sbjct: 531  EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 590

Query: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166
                E+  +LQ+L  L  ++E   +   KL  L +  L  L +KS++     K    L  
Sbjct: 591  KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 646

Query: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215
                W+ + +++  +  +  Q  +    S++QT +         ++ +LV  A +     
Sbjct: 647  FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 706

Query: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269
            P Q  R  T +  I   LD  ITEL  W+   + +L+S    +    G+  ++ + V+ +
Sbjct: 707  PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 766

Query: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318
            +  KA+  ++          L + + N+  ++D     +E+L             +  W 
Sbjct: 767  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 826

Query: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370
              Q+ +     + QQLE M   +  W   +  T       +++L I +      +   P 
Sbjct: 827  EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 886

Query: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426
             +++    I L+E G G    D   +AF N  +++     SD     KE           
Sbjct: 887  IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 932

Query: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486
              Q+I D    +  +  T+ A R        W+Q++ET +++       + ++ D  +  
Sbjct: 933  --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 976

Query: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546
            +   ++Q +Q+ +         +    ++M K    SE +   Q   +++  RW  L ++
Sbjct: 977  QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 1035

Query: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606
                   LE    K  ++   ++ L KW+   D  LK++ P  GD   L+ Q   C+ L 
Sbjct: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1095

Query: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
             +++  + S LN+V++       Q I+   EP    + +TEL                  
Sbjct: 1096 SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1132

Query: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726
            E+  +W+ +       ++ +   LEK   LQ  + ++   M +AE      +       D
Sbjct: 1133 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1191

Query: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
             LQ  +E++   +EE      KVK    +VN + +Q  P+       + ++L+ L   ++
Sbjct: 1192 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1248

Query: 2783 LLQVSVDDRLKQLQE 2797
             L   ++ + K L+E
Sbjct: 1249 WLCTRLNGKCKTLEE 1263



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 2678 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2737

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 2738 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2796

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 2797 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2854

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 3025

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 3026 LLQVAVEDRVRQLHEAHRDFG 3046



 Score = 38.9 bits (89), Expect = 0.089
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
            S  + L  S    +R   +LEE++ WL   ++ L+ Q  I  DV  ++ Q+   +    +
Sbjct: 329  SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388

Query: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
            L   +  V N +      +    +   EE                       +++Q + +
Sbjct: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 427

Query: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723
              +WE L   +   Q  + + L     +KL++L   +   +   ++ E      +P+G  
Sbjct: 428  NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 482

Query: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779
            L D L+  +++    +E++     +   VN L+  +  +D     H +  +  QL  L  
Sbjct: 483  LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 538

Query: 2780 RWKLLQVSVDDRLKQLQE 2797
            RW  +    +DR   LQ+
Sbjct: 539  RWANICRWTEDRWVLLQD 556



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 2854 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2911

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 2912 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2971

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 2972 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 3028

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 3029 VAVEDRVRQLHE 3040


>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
          Length = 3562

 Score = 1643 bits (4254), Expect = 0.0
 Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)

Query: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356
            E  S +  V MDL + +  L+E+  WL   E+  +  E++ +  D+E++K Q   H+   
Sbjct: 317  EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 374

Query: 357  MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416
             +L   Q  V S+      ++   +  D     ++EQ+ +L  RW  +   + DR   L 
Sbjct: 375  EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 432

Query: 417  DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471
            D+L++ Q+   +Q   SAWL+  E+ + K+ T    D    + SLQKL      L++DLE
Sbjct: 433  DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 488

Query: 472  AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
             ++  +  L  +   ++     +S T   E  L      W  + +  E+   ++ +    
Sbjct: 489  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 548

Query: 531  WQELL--------------EEQCLLK---------------------------------- 542
             Q  L               EQ L+K                                  
Sbjct: 549  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 608

Query: 543  -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600
             +W+T  E  L   + + F+ +   S    ++  ++ +   K + L   S   Q  V Q+
Sbjct: 609  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 668

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656
            ++    +  I   SE+L  RW    Q L +  N +      +   +Q+ Q + + T    
Sbjct: 669  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 728

Query: 657  -------------------------------------RVREQAITKKSKQELPP------ 673
                                                 R++ Q+I  K K + P       
Sbjct: 729  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 788

Query: 674  -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723
                   +Q+  D++A++K     FD +      E ++ I  W    +T      + + D
Sbjct: 789  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 848

Query: 724  TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777
               M+++L   +AL+   +E+      L+ T    V++M K+  P+E   + ++  E++ 
Sbjct: 849  YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 903

Query: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
              WK +S  L  +E   +L+E +N    +L +++  I+T ++W+    +    ++  P+L
Sbjct: 904  GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 955

Query: 838  KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885
             DS         C+  ++++  + P +         + ++ + P+F  R          +
Sbjct: 956  GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1014

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939
            +  + + V  R++ L+  L+        +T+   KD+    E   Q     L        
Sbjct: 1015 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1066

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
              +++KA++E K   E  + ++  +  L E   ++     P  ++  K+E + +   +  
Sbjct: 1067 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1126

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L   ++     LEE+        +      KW++ V+  L   +   G    +   LD  
Sbjct: 1127 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1186

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
                N +   E +   ++ +   L  G V  +   +   L  + ++  +L +E   ++  
Sbjct: 1187 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1241

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1242 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1296

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1297 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1349

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1350 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1404

Query: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1465 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1520

Query: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1521 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1580

Query: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1581 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1640

Query: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1641 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1699

Query: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1700 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1759

Query: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1760 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1810

Query: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1811 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1862

Query: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1863 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920

Query: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 1980

Query: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 1981 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2034

Query: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 2035 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2094

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 2095 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2153

Query: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2154 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2213

Query: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2214 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2270

Query: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2271 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2330

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2331 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2387

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2388 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2447

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2448 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2507

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2508 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2567

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2568 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2627

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2628 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2687

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2688 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2747

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2748 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2804

Query: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2805 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2864

Query: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2865 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 2924

Query: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 2925 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 2984

Query: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 2985 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3044

Query: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 3045 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3104

Query: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 3105 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3164

Query: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3165 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3224

Query: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3225 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3284

Query: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3285 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3344

Query: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3345 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3404

Query: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3405 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3464

Query: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3465 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3524

Query: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3525 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3556



 Score = 1560 bits (4040), Expect = 0.0
 Identities = 971/2808 (34%), Positives = 1559/2808 (55%), Gaps = 260/2808 (9%)

Query: 140  MKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSW 199
            MK++M+ LQQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W
Sbjct: 1    MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 60

Query: 200  DKVV-KMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQV 258
            + VV + S  +RLEHAF+ A+  LGIEKLLDPEDV    PDKKSI+MY+TSLF+VLPQQV
Sbjct: 61   NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 120

Query: 259  TIDAIREVETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA--------- 298
            +I+AI+EVE LPR  K   EE           + I +      E   SP+          
Sbjct: 121  SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 180

Query: 299  -------------------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ 333
                               E P      S++ E +++LD YQ ALEEVL+WLLSAEDT Q
Sbjct: 181  AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 240

Query: 334  EQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQ 393
             Q +IS+DVE VKDQF THE +MM+LTAHQ  VG++LQ G++LI  G LS++EE E+QEQ
Sbjct: 241  AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 300

Query: 394  MTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDV 453
            M LLN+RWE LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME  PL  D+
Sbjct: 301  MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 360

Query: 454  KSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAV 513
            + L++ +++HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW  +
Sbjct: 361  EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 420

Query: 514  CRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRL 573
            CRWTE+RW  LQ+I + WQ L EEQCL  AWL+EKE+A+NK+ T+ FKDQ E+  S+++L
Sbjct: 421  CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 480

Query: 574  AILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSN 633
            A+LK D+E K+Q++ +L  + QD+   L N   ++K  +  +   + WD+LVQ+LE S+ 
Sbjct: 481  AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 540

Query: 634  QVTQAV--AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKK 691
            Q++QAV   +  ++Q    + + TV  REQ + K +++ELPPPPP KKRQI VD E +K+
Sbjct: 541  QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600

Query: 692  FDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQT 751
             D    EL +WI + +  +Q+ E   + K  + S++K+K+ A+E+E+ E+  +  + +++
Sbjct: 601  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660

Query: 752  GQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELE 811
             Q LVEQM  EG+  + IK   E+++S W    Q L +    ++ Q +I A++ QL +LE
Sbjct: 661  AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720

Query: 812  KVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSA 871
            ++  T E W+K    + S   ++ S    C+ E+  L GL P+IE  +    AL  +   
Sbjct: 721  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780

Query: 872  PDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQ 931
            P F+   F +F   ++ V   V+ R++ L+      P   Y ET+  ++  +  SE K  
Sbjct: 781  PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 840

Query: 932  VSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFD 991
            +    + D   +E+ L E + L   L+ Q+  L+ L+   K + K    ++ + Y+ EF+
Sbjct: 841  IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 900

Query: 992  DVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAG 1051
            +++G+W KL   + +    LEE    LR  +     ++KWM  V  FL ++  A GD   
Sbjct: 901  EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 960

Query: 1052 LQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSK 1111
            L++QL QC   V++I+TI+ SL ++ E    +++       + ++T L +  TQ + + +
Sbjct: 961  LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020

Query: 1112 EIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA 1171
            ++  +K  L    EK  +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRA
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080

Query: 1172 KEDVLQKEVRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEE 1230
            KE+  QKE +VK+L +++  + A+ P   QE L  EL  +  NYQ LC R+ GKC TLEE
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1140

Query: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQI 1290
            VW+CW ELL YL+    WLN +E ++K+TE +P   + ++E L+SLE+++RH  DN  QI
Sbjct: 1141 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200

Query: 1291 RELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQ 1350
            R L QTL DGG++D++I+E+LE FNSR+ +L   A  +Q  LE+ +Q  +ET++ L ++Q
Sbjct: 1201 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1260

Query: 1351 ESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRT 1410
            ESL  +DKQL  Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ +       +   
Sbjct: 1261 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAA 1314

Query: 1411 ARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDV 1470
             R  SQ+DV Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK  L  L+ K V+ +V
Sbjct: 1315 QRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEV 1374

Query: 1471 IQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGA 1530
            +Q+ L+ C+ LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA
Sbjct: 1375 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGA 1434

Query: 1531 QVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNV 1590
            +VTE KQ LE+  +L+RKM+KE   L+EWL+AT+ EL ++S  EG+  +LD+E++W K  
Sbjct: 1435 KVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT 1494

Query: 1591 LKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH 1650
             K++EK+K  L +ITE   AL+ ++   E ++E++L +LN+ W  V +  E+W N L+ +
Sbjct: 1495 QKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEY 1554

Query: 1651 QNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQ 1710
            Q  +E FD NV HI+ W+ QA+ LLDE EKK   ++E+++KRL +EL+D   +V++ RDQ
Sbjct: 1555 QKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQ 1614

Query: 1711 ALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGV 1770
            A  LM  RG   R+LVEP+++ELN  F  +S  IK+ K                     +
Sbjct: 1615 AANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASI 1655

Query: 1771 PFSDLEKLENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQP 1823
            P  +LE+  +DI+ +L+ +E       +L+  D ++ M+E++   ++E+LQRG+ +  + 
Sbjct: 1656 PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRI 1715

Query: 1824 MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCM 1883
             ++ K+E+I+++  LL T++N +K +  Q+RK       +  S     Y  + + +L C+
Sbjct: 1716 TDERKREEIKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCL 1770

Query: 1884 DDVELSL-NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPE 1942
            DD+E  L ++PE            E  +K I  +L K  E++  +  +   +  + +   
Sbjct: 1771 DDIEKKLASLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--- 1818

Query: 1943 AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FH 1982
            A+ +  T  QL+ +W  I   ++  +      +   R+                    + 
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878

Query: 1983 CDLNDLTQWITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGD 2040
             ++  ++Q + E E+LL   D CA     DL K     + ++  +         ++    
Sbjct: 1879 TEITHVSQALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 1937

Query: 2041 GIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWL 2100
              +Q  +  +   L+E L+ L+ +W+ +    KDRQ R     ++  ++ + +     WL
Sbjct: 1938 AALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL 1997

Query: 2101 TKAEHAMQKRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPER 2157
            T+AE  ++K    E  E+ +    L++L   +      ++ LN T  E++   S +  + 
Sbjct: 1998 TEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DA 2055

Query: 2158 DKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPV 2217
              + E L ++N+ W ++C+++    K   ++ + +S+ +     ++ + VL    +D   
Sbjct: 2056 SILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--- 2108

Query: 2218 QSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLE 2277
                 +  SIP +  K            +Q LK  +      E++   V  + + +  L+
Sbjct: 2109 -----NIASIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILK 2145

Query: 2278 QRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIID 2337
            Q +       T    L +   S + +  +  KL++   QW      +  +Q ++E  I D
Sbjct: 2146 QLNE------TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKD 2199

Query: 2338 SLQWDDHREETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGI 2390
              Q +   E+ EE +            +L I  Q  ++     + + +I +Q   P    
Sbjct: 2200 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEE 2258

Query: 2391 VMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQA 2447
            +++    L K         T+ VK   E L + W  +N L Q +  +Q  L     T+ A
Sbjct: 2259 ILSKGQHLYK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2313

Query: 2448 SRRDLENFL-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ 2491
            S       + + +   ET ++              L D +     L D  S+L + +K Q
Sbjct: 2314 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2373

Query: 2492 ------MQDIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDD 2535
                  ++DI   I       + ++  R          Q +     N E  T++  R++ 
Sbjct: 2374 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2433

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELK 2583
            +  +W++       ++ HL+   ++ N +   L++  +WL  K+E            E  
Sbjct: 2434 IQNQWDE-------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESW 2483

Query: 2584 KQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQ 2643
            K+ P    V A+Q +    K L ++L++ + +V  A D A   L D       +  R + 
Sbjct: 2484 KEGPY--TVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVH 2537

Query: 2644 SKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL 2703
              T     E      +++ K+ SE +   E  + +   +   ++K L  L + +   + L
Sbjct: 2538 MIT-----ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVL 2592

Query: 2704 -DADMKE-----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFK 2748
             DA  KE     ++ V+   K   DL         +  +L ++ +KI+   E        
Sbjct: 2593 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLL 2652

Query: 2749 VKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796
             + +++++ + S L    SL +   L+  + +WK L +S+ + L  LQ
Sbjct: 2653 QRRLDNMNFKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2699



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 1790 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1849

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 1850 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 1906

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 1907 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 1964

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 1965 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2022

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 2023 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 2081 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2138

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 2139 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2195

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 2196 QIKDLGQLEKKLEDL--------------------------------------------E 2211

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 2212 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2267

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 2268 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2320

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 2321 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2380

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 2381 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2440

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 2441 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2498

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 2499 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2558

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 2559 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2617

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 2618 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2677

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 2678 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2736

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 2737 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2796

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 2797 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2845

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 2846 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 2882



 Score =  102 bits (255), Expect = 5e-21
 Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)

Query: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
            S  E  ++++ +  LN++W+ +     +++    R + + +  +  L +L  W+T+ EE 
Sbjct: 290  SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 347

Query: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
               ++    G  L+  K ++ Q + L+  +   Q    +L      + +       + L+
Sbjct: 348  TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 407

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113
            E+L  L  RW  I    +DR   L+    +  +   +      WL++ E A+ K  TT  
Sbjct: 408  EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 467

Query: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166
                E+  +LQ+L  L  ++E   +   KL  L +  L  L +KS++     K    L  
Sbjct: 468  KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 523

Query: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215
                W+ + +++  +  +  Q  +    S++QT +         ++ +LV  A +     
Sbjct: 524  FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 583

Query: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269
            P Q  R  T +  I   LD  ITEL  W+   + +L+S    +    G+  ++ + V+ +
Sbjct: 584  PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 643

Query: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318
            +  KA+  ++          L + + N+  ++D     +E+L             +  W 
Sbjct: 644  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 703

Query: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370
              Q+ +     + QQLE M   +  W   +  T       +++L I +      +   P 
Sbjct: 704  EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 763

Query: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426
             +++    I L+E G G    D   +AF N  +++     SD     KE           
Sbjct: 764  IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 809

Query: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486
              Q+I D    +  +  T+ A R        W+Q++ET +++       + ++ D  +  
Sbjct: 810  --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 853

Query: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546
            +   ++Q +Q+ +         +    ++M K    SE +   Q   +++  RW  L ++
Sbjct: 854  QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 912

Query: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606
                   LE    K  ++   ++ L KW+   D  LK++ P  GD   L+ Q   C+ L 
Sbjct: 913  LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 972

Query: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
             +++  + S LN+V++       Q I+   EP    + +TEL                  
Sbjct: 973  SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1009

Query: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726
            E+  +W+ +       ++ +   LEK   LQ  + ++   M +AE      +       D
Sbjct: 1010 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1068

Query: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
             LQ  +E++   +EE      KVK    +VN + +Q  P+       + ++L+ L   ++
Sbjct: 1069 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1125

Query: 2783 LLQVSVDDRLKQLQE 2797
             L   ++ + K L+E
Sbjct: 1126 WLCTRLNGKCKTLEE 1140



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 2555 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2614

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 2615 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2673

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 2674 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2731

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 2732 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2791

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 2792 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2851

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 2902

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 2903 LLQVAVEDRVRQLHEAHRDFG 2923



 Score = 38.9 bits (89), Expect = 0.089
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
            S  + L  S    +R   +LEE++ WL   ++ L+ Q  I  DV  ++ Q+   +    +
Sbjct: 206  SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 265

Query: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
            L   +  V N +      +    +   EE                       +++Q + +
Sbjct: 266  LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 304

Query: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723
              +WE L   +   Q  + + L     +KL++L   +   +   ++ E      +P+G  
Sbjct: 305  NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 359

Query: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779
            L D L+  +++    +E++     +   VN L+  +  +D     H +  +  QL  L  
Sbjct: 360  LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 415

Query: 2780 RWKLLQVSVDDRLKQLQE 2797
            RW  +    +DR   LQ+
Sbjct: 416  RWANICRWTEDRWVLLQD 433



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 2731 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2788

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 2789 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2848

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 2849 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 2905

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 2906 VAVEDRVRQLHE 2917


>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
          Length = 3562

 Score = 1643 bits (4254), Expect = 0.0
 Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)

Query: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356
            E  S +  V MDL + +  L+E+  WL   E+  +  E++ +  D+E++K Q   H+   
Sbjct: 317  EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 374

Query: 357  MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416
             +L   Q  V S+      ++   +  D     ++EQ+ +L  RW  +   + DR   L 
Sbjct: 375  EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 432

Query: 417  DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471
            D+L++ Q+   +Q   SAWL+  E+ + K+ T    D    + SLQKL      L++DLE
Sbjct: 433  DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 488

Query: 472  AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
             ++  +  L  +   ++     +S T   E  L      W  + +  E+   ++ +    
Sbjct: 489  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 548

Query: 531  WQELL--------------EEQCLLK---------------------------------- 542
             Q  L               EQ L+K                                  
Sbjct: 549  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 608

Query: 543  -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600
             +W+T  E  L   + + F+ +   S    ++  ++ +   K + L   S   Q  V Q+
Sbjct: 609  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 668

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656
            ++    +  I   SE+L  RW    Q L +  N +      +   +Q+ Q + + T    
Sbjct: 669  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 728

Query: 657  -------------------------------------RVREQAITKKSKQELPP------ 673
                                                 R++ Q+I  K K + P       
Sbjct: 729  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 788

Query: 674  -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723
                   +Q+  D++A++K     FD +      E ++ I  W    +T      + + D
Sbjct: 789  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 848

Query: 724  TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777
               M+++L   +AL+   +E+      L+ T    V++M K+  P+E   + ++  E++ 
Sbjct: 849  YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 903

Query: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
              WK +S  L  +E   +L+E +N    +L +++  I+T ++W+    +    ++  P+L
Sbjct: 904  GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 955

Query: 838  KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885
             DS         C+  ++++  + P +         + ++ + P+F  R          +
Sbjct: 956  GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1014

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939
            +  + + V  R++ L+  L+        +T+   KD+    E   Q     L        
Sbjct: 1015 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1066

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
              +++KA++E K   E  + ++  +  L E   ++     P  ++  K+E + +   +  
Sbjct: 1067 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1126

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L   ++     LEE+        +      KW++ V+  L   +   G    +   LD  
Sbjct: 1127 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1186

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
                N +   E +   ++ +   L  G V  +   +   L  + ++  +L +E   ++  
Sbjct: 1187 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1241

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1242 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1296

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1297 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1349

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1350 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1404

Query: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1465 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1520

Query: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1521 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1580

Query: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1581 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1640

Query: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1641 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1699

Query: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1700 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1759

Query: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1760 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1810

Query: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1811 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1862

Query: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1863 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920

Query: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 1980

Query: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 1981 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2034

Query: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 2035 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2094

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 2095 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2153

Query: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2154 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2213

Query: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2214 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2270

Query: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2271 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2330

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2331 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2387

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2388 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2447

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2448 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2507

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2508 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2567

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2568 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2627

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2628 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2687

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2688 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2747

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2748 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2804

Query: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2805 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2864

Query: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2865 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 2924

Query: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 2925 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 2984

Query: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 2985 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3044

Query: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 3045 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3104

Query: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 3105 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3164

Query: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3165 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3224

Query: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3225 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3284

Query: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3285 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3344

Query: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3345 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3404

Query: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3405 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3464

Query: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3465 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3524

Query: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3525 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3556



 Score = 1560 bits (4040), Expect = 0.0
 Identities = 971/2808 (34%), Positives = 1559/2808 (55%), Gaps = 260/2808 (9%)

Query: 140  MKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSW 199
            MK++M+ LQQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W
Sbjct: 1    MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 60

Query: 200  DKVV-KMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQV 258
            + VV + S  +RLEHAF+ A+  LGIEKLLDPEDV    PDKKSI+MY+TSLF+VLPQQV
Sbjct: 61   NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 120

Query: 259  TIDAIREVETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA--------- 298
            +I+AI+EVE LPR  K   EE           + I +      E   SP+          
Sbjct: 121  SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 180

Query: 299  -------------------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ 333
                               E P      S++ E +++LD YQ ALEEVL+WLLSAEDT Q
Sbjct: 181  AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 240

Query: 334  EQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQ 393
             Q +IS+DVE VKDQF THE +MM+LTAHQ  VG++LQ G++LI  G LS++EE E+QEQ
Sbjct: 241  AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 300

Query: 394  MTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDV 453
            M LLN+RWE LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME  PL  D+
Sbjct: 301  MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 360

Query: 454  KSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAV 513
            + L++ +++HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW  +
Sbjct: 361  EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 420

Query: 514  CRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRL 573
            CRWTE+RW  LQ+I + WQ L EEQCL  AWL+EKE+A+NK+ T+ FKDQ E+  S+++L
Sbjct: 421  CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 480

Query: 574  AILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSN 633
            A+LK D+E K+Q++ +L  + QD+   L N   ++K  +  +   + WD+LVQ+LE S+ 
Sbjct: 481  AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 540

Query: 634  QVTQAV--AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKK 691
            Q++QAV   +  ++Q    + + TV  REQ + K +++ELPPPPP KKRQI VD E +K+
Sbjct: 541  QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600

Query: 692  FDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQT 751
             D    EL +WI + +  +Q+ E   + K  + S++K+K+ A+E+E+ E+  +  + +++
Sbjct: 601  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660

Query: 752  GQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELE 811
             Q LVEQM  EG+  + IK   E+++S W    Q L +    ++ Q +I A++ QL +LE
Sbjct: 661  AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720

Query: 812  KVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSA 871
            ++  T E W+K    + S   ++ S    C+ E+  L GL P+IE  +    AL  +   
Sbjct: 721  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780

Query: 872  PDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQ 931
            P F+   F +F   ++ V   V+ R++ L+      P   Y ET+  ++  +  SE K  
Sbjct: 781  PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 840

Query: 932  VSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFD 991
            +    + D   +E+ L E + L   L+ Q+  L+ L+   K + K    ++ + Y+ EF+
Sbjct: 841  IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 900

Query: 992  DVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAG 1051
            +++G+W KL   + +    LEE    LR  +     ++KWM  V  FL ++  A GD   
Sbjct: 901  EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 960

Query: 1052 LQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSK 1111
            L++QL QC   V++I+TI+ SL ++ E    +++       + ++T L +  TQ + + +
Sbjct: 961  LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020

Query: 1112 EIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA 1171
            ++  +K  L    EK  +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRA
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080

Query: 1172 KEDVLQKEVRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEE 1230
            KE+  QKE +VK+L +++  + A+ P   QE L  EL  +  NYQ LC R+ GKC TLEE
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1140

Query: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQI 1290
            VW+CW ELL YL+    WLN +E ++K+TE +P   + ++E L+SLE+++RH  DN  QI
Sbjct: 1141 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200

Query: 1291 RELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQ 1350
            R L QTL DGG++D++I+E+LE FNSR+ +L   A  +Q  LE+ +Q  +ET++ L ++Q
Sbjct: 1201 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1260

Query: 1351 ESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRT 1410
            ESL  +DKQL  Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ +       +   
Sbjct: 1261 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAA 1314

Query: 1411 ARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDV 1470
             R  SQ+DV Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK  L  L+ K V+ +V
Sbjct: 1315 QRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEV 1374

Query: 1471 IQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGA 1530
            +Q+ L+ C+ LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA
Sbjct: 1375 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGA 1434

Query: 1531 QVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNV 1590
            +VTE KQ LE+  +L+RKM+KE   L+EWL+AT+ EL ++S  EG+  +LD+E++W K  
Sbjct: 1435 KVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT 1494

Query: 1591 LKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH 1650
             K++EK+K  L +ITE   AL+ ++   E ++E++L +LN+ W  V +  E+W N L+ +
Sbjct: 1495 QKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEY 1554

Query: 1651 QNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQ 1710
            Q  +E FD NV HI+ W+ QA+ LLDE EKK   ++E+++KRL +EL+D   +V++ RDQ
Sbjct: 1555 QKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQ 1614

Query: 1711 ALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGV 1770
            A  LM  RG   R+LVEP+++ELN  F  +S  IK+ K                     +
Sbjct: 1615 AANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASI 1655

Query: 1771 PFSDLEKLENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQP 1823
            P  +LE+  +DI+ +L+ +E       +L+  D ++ M+E++   ++E+LQRG+ +  + 
Sbjct: 1656 PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRI 1715

Query: 1824 MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCM 1883
             ++ K+E+I+++  LL T++N +K +  Q+RK       +  S     Y  + + +L C+
Sbjct: 1716 TDERKREEIKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCL 1770

Query: 1884 DDVELSL-NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPE 1942
            DD+E  L ++PE            E  +K I  +L K  E++  +  +   +  + +   
Sbjct: 1771 DDIEKKLASLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--- 1818

Query: 1943 AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FH 1982
            A+ +  T  QL+ +W  I   ++  +      +   R+                    + 
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878

Query: 1983 CDLNDLTQWITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGD 2040
             ++  ++Q + E E+LL   D CA     DL K     + ++  +         ++    
Sbjct: 1879 TEITHVSQALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 1937

Query: 2041 GIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWL 2100
              +Q  +  +   L+E L+ L+ +W+ +    KDRQ R     ++  ++ + +     WL
Sbjct: 1938 AALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL 1997

Query: 2101 TKAEHAMQKRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPER 2157
            T+AE  ++K    E  E+ +    L++L   +      ++ LN T  E++   S +  + 
Sbjct: 1998 TEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DA 2055

Query: 2158 DKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPV 2217
              + E L ++N+ W ++C+++    K   ++ + +S+ +     ++ + VL    +D   
Sbjct: 2056 SILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--- 2108

Query: 2218 QSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLE 2277
                 +  SIP +  K            +Q LK  +      E++   V  + + +  L+
Sbjct: 2109 -----NIASIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILK 2145

Query: 2278 QRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIID 2337
            Q +       T    L +   S + +  +  KL++   QW      +  +Q ++E  I D
Sbjct: 2146 QLNE------TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKD 2199

Query: 2338 SLQWDDHREETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGI 2390
              Q +   E+ EE +            +L I  Q  ++     + + +I +Q   P    
Sbjct: 2200 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEE 2258

Query: 2391 VMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQA 2447
            +++    L K         T+ VK   E L + W  +N L Q +  +Q  L     T+ A
Sbjct: 2259 ILSKGQHLYK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2313

Query: 2448 SRRDLENFL-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ 2491
            S       + + +   ET ++              L D +     L D  S+L + +K Q
Sbjct: 2314 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2373

Query: 2492 ------MQDIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDD 2535
                  ++DI   I       + ++  R          Q +     N E  T++  R++ 
Sbjct: 2374 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2433

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELK 2583
            +  +W++       ++ HL+   ++ N +   L++  +WL  K+E            E  
Sbjct: 2434 IQNQWDE-------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESW 2483

Query: 2584 KQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQ 2643
            K+ P    V A+Q +    K L ++L++ + +V  A D A   L D       +  R + 
Sbjct: 2484 KEGPY--TVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVH 2537

Query: 2644 SKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL 2703
              T     E      +++ K+ SE +   E  + +   +   ++K L  L + +   + L
Sbjct: 2538 MIT-----ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVL 2592

Query: 2704 -DADMKE-----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFK 2748
             DA  KE     ++ V+   K   DL         +  +L ++ +KI+   E        
Sbjct: 2593 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLL 2652

Query: 2749 VKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796
             + +++++ + S L    SL +   L+  + +WK L +S+ + L  LQ
Sbjct: 2653 QRRLDNMNFKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2699



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 1790 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1849

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 1850 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 1906

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 1907 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 1964

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 1965 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2022

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 2023 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 2081 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2138

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 2139 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2195

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 2196 QIKDLGQLEKKLEDL--------------------------------------------E 2211

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 2212 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2267

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 2268 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2320

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 2321 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2380

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 2381 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2440

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 2441 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2498

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 2499 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2558

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 2559 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2617

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 2618 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2677

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 2678 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2736

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 2737 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2796

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 2797 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2845

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 2846 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 2882



 Score =  102 bits (255), Expect = 5e-21
 Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)

Query: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
            S  E  ++++ +  LN++W+ +     +++    R + + +  +  L +L  W+T+ EE 
Sbjct: 290  SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 347

Query: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
               ++    G  L+  K ++ Q + L+  +   Q    +L      + +       + L+
Sbjct: 348  TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 407

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113
            E+L  L  RW  I    +DR   L+    +  +   +      WL++ E A+ K  TT  
Sbjct: 408  EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 467

Query: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166
                E+  +LQ+L  L  ++E   +   KL  L +  L  L +KS++     K    L  
Sbjct: 468  KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 523

Query: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215
                W+ + +++  +  +  Q  +    S++QT +         ++ +LV  A +     
Sbjct: 524  FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 583

Query: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269
            P Q  R  T +  I   LD  ITEL  W+   + +L+S    +    G+  ++ + V+ +
Sbjct: 584  PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 643

Query: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318
            +  KA+  ++          L + + N+  ++D     +E+L             +  W 
Sbjct: 644  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 703

Query: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370
              Q+ +     + QQLE M   +  W   +  T       +++L I +      +   P 
Sbjct: 704  EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 763

Query: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426
             +++    I L+E G G    D   +AF N  +++     SD     KE           
Sbjct: 764  IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 809

Query: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486
              Q+I D    +  +  T+ A R        W+Q++ET +++       + ++ D  +  
Sbjct: 810  --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 853

Query: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546
            +   ++Q +Q+ +         +    ++M K    SE +   Q   +++  RW  L ++
Sbjct: 854  QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 912

Query: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606
                   LE    K  ++   ++ L KW+   D  LK++ P  GD   L+ Q   C+ L 
Sbjct: 913  LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 972

Query: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
             +++  + S LN+V++       Q I+   EP    + +TEL                  
Sbjct: 973  SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1009

Query: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726
            E+  +W+ +       ++ +   LEK   LQ  + ++   M +AE      +       D
Sbjct: 1010 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1068

Query: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
             LQ  +E++   +EE      KVK    +VN + +Q  P+       + ++L+ L   ++
Sbjct: 1069 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1125

Query: 2783 LLQVSVDDRLKQLQE 2797
             L   ++ + K L+E
Sbjct: 1126 WLCTRLNGKCKTLEE 1140



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 2555 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2614

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 2615 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2673

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 2674 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2731

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 2732 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2791

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 2792 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2851

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 2902

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 2903 LLQVAVEDRVRQLHEAHRDFG 2923



 Score = 38.9 bits (89), Expect = 0.089
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
            S  + L  S    +R   +LEE++ WL   ++ L+ Q  I  DV  ++ Q+   +    +
Sbjct: 206  SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 265

Query: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
            L   +  V N +      +    +   EE                       +++Q + +
Sbjct: 266  LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 304

Query: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723
              +WE L   +   Q  + + L     +KL++L   +   +   ++ E      +P+G  
Sbjct: 305  NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 359

Query: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779
            L D L+  +++    +E++     +   VN L+  +  +D     H +  +  QL  L  
Sbjct: 360  LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 415

Query: 2780 RWKLLQVSVDDRLKQLQE 2797
            RW  +    +DR   LQ+
Sbjct: 416  RWANICRWTEDRWVLLQD 433



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 2731 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2788

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 2789 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2848

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 2849 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 2905

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 2906 VAVEDRVRQLHE 2917


>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
          Length = 2341

 Score = 1561 bits (4041), Expect = 0.0
 Identities = 935/2388 (39%), Positives = 1401/2388 (58%), Gaps = 119/2388 (4%)

Query: 1105 QLEKLSKEIATQKSRLSE-SQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELES 1163
            +L  LS + A ++ +L E S + A   +K L  +QE +T     ++++       +++++
Sbjct: 5    KLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDA 59

Query: 1164 AV--EEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRI 1221
            A   +E ++ + D+   E+ ++ +K + +   A      Q + S+++V  +  Q +  + 
Sbjct: 60   AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKF 114

Query: 1222 R--GKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESV 1279
            R   K    E+      E    LD     L  LE +    EV+  + +      +SL  V
Sbjct: 115  RLFQKPANFEQRLQ---ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 171

Query: 1280 LRHPADNRTQIRELGQTLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQ 1337
                      + + G+ ++     ++   + E++ A    Y +L      ++  LEK L+
Sbjct: 172  ----KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 227

Query: 1338 VLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
            + R+  + + VL E L   D +LT     R     +P       A   A +  +E+ + +
Sbjct: 228  LSRKMRKEMNVLTEWLAATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283

Query: 1398 MRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAE 1457
            ++S        +T  G  +  V  +     S    +  +   +   +L+ ++ ++     
Sbjct: 284  LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343

Query: 1458 LHVLDVKDVDPDVI---------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQT 1508
            +  +    +  D +         Q   D   +L   L++++ +V++      +++  +  
Sbjct: 344  VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403

Query: 1509 DNPKGMDEQLTSLKVLYNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSA 1562
               K ++ Q++ L   +  +  ++  GK     ++LE+  S + + ++   A + + ++ 
Sbjct: 404  HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNL 463

Query: 1563 TETELVQKSTSEGLLGDLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEP 1620
             E +   K  +E   G +   +    N+ + +  E+++ ++    +      N ++    
Sbjct: 464  KEEDF-NKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRS 522

Query: 1621 ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK 1680
               ++   ++  W + +   +D    L + + +L               + E  + EI++
Sbjct: 523  QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDR 573

Query: 1681 KPTSKQEEI--VKRLVSEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR- 1735
            +   K+EE+  V+R    L  D A + VE  + Q         S     +E K A+  R 
Sbjct: 574  ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRL 625

Query: 1736 NFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLES 1795
            NF ++    +   +++ ++   +      T+ T +       LE  +E +L   +   + 
Sbjct: 626  NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKD 683

Query: 1796 SDEDEKMDEESAQIEEVLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIK 1847
             ++  K +E    I++ LQ+     +++H             E+++LQ  L    +   K
Sbjct: 684  FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 743

Query: 1848 AIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQ 1906
               + + + G+    +         +   N+ L   +       +PE    A Y+ +   
Sbjct: 744  VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--- 800

Query: 1907 EDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSD 1966
               LK ++D + +    +  ++    ++I ++S  +A  +++ L  LN +W  + +  SD
Sbjct: 801  ---LKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 857

Query: 1967 RKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-I 2025
            RK   +       +F  DLN+   W+ EA+ +      PG    L K ++ Q +L V  +
Sbjct: 858  RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916

Query: 2026 SSHQPSFAALNRTGDGIVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE- 2082
               Q     LN TG  ++    +S  +   L+ KL   N +W  +   + ++Q  ++ + 
Sbjct: 917  PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 976

Query: 2083 ------SKQVMKYRHQLDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAE 2134
                   K++     QL+ ++ WL+   + ++   +   E   ++QE     Q  +   E
Sbjct: 977  KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036

Query: 2135 KLKWLNRTELEMLSDKSLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
            ++  L++ +  +  +K  + P + K+   S   + VN    ++  + P          +S
Sbjct: 1037 EI--LSKGQ-HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1093

Query: 2192 VSQT-RIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLK 2250
             +QT  +   P V K   +S    + + S    E+   AD ++  TEL DWL L+DQ++K
Sbjct: 1094 PTQTVTLVTQPVVTKETAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150

Query: 2251 SNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKL 2310
            S  V VGD+E+IN+ + + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++
Sbjct: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210

Query: 2311 ERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--D 2368
            ER++NQWD  Q  ++ R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D
Sbjct: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270

Query: 2369 PLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLK 2428
             + K+I++ + L ++L      V   +++  KLL +Y +DDTR V   TE +  SW ++ 
Sbjct: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330

Query: 2429 QSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAREL 2488
            + +++R+ ALE   R +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL
Sbjct: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390

Query: 2489 KQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSA 2548
             +Q QD+Q EI+AH D++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS 
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
            +IR+HLEAS+++W RL +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RE
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510

Query: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
            LK KE  +++ ++  R+FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEV 1567

Query: 2669 KEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSL 2728
              +WE LN  +++WQ+++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSL
Sbjct: 1568 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 1627

Query: 2729 QDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSV 2788
            QDH+EK+ A R EIAP+   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V
Sbjct: 1628 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAV 1687

Query: 2789 DDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTEL 2848
            +DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL
Sbjct: 1688 EDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTEL 1747

Query: 2849 FQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVI 2908
            +QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +I
Sbjct: 1748 YQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQII 1807

Query: 2909 NCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLL 2968
            NCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  L
Sbjct: 1808 NCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHL 1867

Query: 2969 EEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNN 3028
            E+KYRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  N
Sbjct: 1868 EDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFAN 1927

Query: 3029 NKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKH 3088
            NKPEI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKH
Sbjct: 1928 NKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKH 1987

Query: 3089 FNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPR 3148
            FNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR
Sbjct: 1988 FNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPR 2047

Query: 3149 LGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTN 3208
            +GYLPVQTVLEGDN+ETP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +N
Sbjct: 2048 MGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSN 2107

Query: 3209 GSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIA 3268
            GS+L DS S   S++DEH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+A
Sbjct: 2108 GSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILA 2167

Query: 3269 DLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGR 3327
            DLEEE RNLQ EY++LK QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGR
Sbjct: 2168 DLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGR 2227

Query: 3328 LEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDA 3384
            LEARMQILEDHNKQLESQLHRLRQLLEQP++++++NG    SP  S Q S  S  +    
Sbjct: 2228 LEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRV 2287

Query: 3385 SGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
             G Q   + G EDLL+PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 2288 VGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 2335



 Score =  137 bits (346), Expect = 1e-31
 Identities = 333/1726 (19%), Positives = 656/1726 (38%), Gaps = 264/1726 (15%)

Query: 887  QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA 946
            Q +Q  +   +  LE   K   G    + + +  DV         +   +    A  E+ 
Sbjct: 67   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQR 126

Query: 947  LQEKKTLDEILENQKPALHKLAEETKALEKN-------------VHPDVEKLYKQEFDDV 993
            LQE K + + ++   PAL   + E + ++               V  +VE + K     V
Sbjct: 127  LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 186

Query: 994  QGK------------------WNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGV 1035
            Q K                  +N+L   V++    LE+     R    +  V+ +W+   
Sbjct: 187  QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 246

Query: 1036 KDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIK-TW 1094
               L K+ A +G  + L  ++    A   EIE  +  LK++ E+   L++  V G K T 
Sbjct: 247  DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETL 304

Query: 1095 VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154
            V+ +L    +    ++       + L E Q+      +++  + +W+ QA+   L  + E
Sbjct: 305  VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT--LLDESE 362

Query: 1155 YKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELT----SELNVV 1210
             K P++ E  ++ +K    D+  K   V   +D    L A      ++L     SELN  
Sbjct: 363  KKKPQQKEDVLKRLKAELNDIRPK---VDSTRDQAANLMANRGDHCRKLVEPQISELN-- 417

Query: 1211 LENYQLLCNRIR-GKC----HTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEK 1265
               +  + +RI+ GK       LE+  S   +LL  L+ E      L+E   + ++  + 
Sbjct: 418  -HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDN 476

Query: 1266 TDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLA 1325
               V E L+  +++ +   D R +  E+            I  + L+  ++  +DL    
Sbjct: 477  EGTVKELLQRGDNLQQRITDERKR-EEI-----------KIKQQLLQTKHNALKDLRSQR 524

Query: 1326 ESKQISLEKQ-LQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384
              K + +  Q  Q  R+ D +L+ L     +++K+L +    R +     ++ ++I  E+
Sbjct: 525  RKKALEISHQWYQYKRQADDLLKCLD----DIEKKLASLPEPRDE-----RKIKEIDREL 575

Query: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF---- 1440
               +  L  +RR  +++ L+   +  A   +Q+  L ++ RE+ +KF  F++  NF    
Sbjct: 576  QKKKEELNAVRR--QAEGLSEDGAAMAVEPTQIQ-LSKRWREIESKFAQFRR-LNFAQIH 631

Query: 1441 -----------EQRMLDCKRVLDGVKAEL-HV----LDVKDV--DPDVIQTHLDKCMKLY 1482
                       E   L+   V      E+ HV    L+V+ +   PD+     +   K  
Sbjct: 632  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 691

Query: 1483 KTLSEVKLEVETVIKTGR-HIVQKQQTDNPKG--------MDEQLTSLKVLYNDLGAQVT 1533
            ++L  +K  ++    +GR  I+  ++T   +         + E L+ L   +  +     
Sbjct: 692  ESLKNIKDSLQQ--SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 749

Query: 1534 EGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKD 1593
            + +   +R+ +  R+   +    ++WL+  E  L +    E      + E +  K  LK+
Sbjct: 750  DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE------NWEHAKYKWYLKE 803

Query: 1594 LEKRKADLNTITES-SAALQNLIEGSE----PILEERLCVLNAGWSRVRTWTEDWCNTLM 1648
            L+       T+  + +A  + +I+ S      IL+E+L  LN  W  V     D    L 
Sbjct: 804  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863

Query: 1649 NHQNQLEIFDGNVAHISTWLYQAEAL----LDEIEKKPTSKQEEIVKRLVSELD--DANL 1702
              +N L  F  ++     WL +A+ +    L+  +++   ++ E VK LV EL      L
Sbjct: 864  EQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 923

Query: 1703 QVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVT 1762
            +  N     +++        ++ +E KL + N  + KVS+ +          P  Q  + 
Sbjct: 924  KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL----------PEKQGEIE 973

Query: 1763 TETFETGVPFSDLEKLENDIENMLKFV---------------EKHLESSDEDEKMDEESA 1807
             +  + G     LE LE  + ++L ++               E   +  + +  +  +  
Sbjct: 974  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1033

Query: 1808 QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR-KMGQLASGIRS- 1865
             +EE+L +G+   H   E    + ++ +L  L + +  +  +  + R K   LA G+ + 
Sbjct: 1034 DVEEILSKGQ---HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090

Query: 1866 SLLPTDYLVEINKILLCMDDVELSLNVPE---LNTAIYEDFSFQEDSLKN--------IK 1914
               PT  +  + + ++  +     L +P    L      DF+     L +        IK
Sbjct: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150

Query: 1915 DQLDKLGE----QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAK----------WDRI 1960
             Q   +G+       +I +K     LE   P+  ++      L  K           DRI
Sbjct: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210

Query: 1961 NRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWI---TEAEELLVDTCA--------PGGSL 2009
             R+ +      +      +Q +  L D TQW+    EAE++L    A        P    
Sbjct: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270

Query: 2010 DLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIV 2069
             ++K     ++L   +   Q +    N     +++  S  D   +      +N  W +I 
Sbjct: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330

Query: 2070 AEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAMQKRSTTELGENLQEL 2122
              V +R+  L+   + + ++   L++ + WLT+AE        A +K    E  + ++EL
Sbjct: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390

Query: 2123 ----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERDKISESLRTVNMTWNK 2173
                +DL  E+E H +    L+    ++L     SD ++ L  R      L  +N  W++
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR------LDNMNFKWSE 1444

Query: 2174 ICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDK 2233
            + ++                                     + ++SH  +       L  
Sbjct: 1445 LRKK------------------------------------SLNIRSHLEASSDQWKRLHL 1468

Query: 2234 TITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNL 2293
            ++ EL  WL L D  L       GD   + K     +  K +L+ + P +       +  
Sbjct: 1469 SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIF 1528

Query: 2294 KNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR 2353
              +     +     E  E      +  Q+   L ++Q E++   + +W+     + +  R
Sbjct: 1529 LTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---NTEWEKLNLHSADWQR 1583

Query: 2354 KYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFDNVLQKLLEEYG---- 2406
            K +  L  LQ  Q   D L  ++   +++     P GD ++ +  + L+K+    G    
Sbjct: 1584 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 1643

Query: 2407 -SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRD 2451
              ++  +V +    L T  I L          L   W+ +Q +  D
Sbjct: 1644 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 1689



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 569  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 629  QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 685

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 686  --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 743

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 744  VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 801

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 802  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 860  KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 917

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 918  LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 975  QIKDLGQLEKKLEDL--------------------------------------------E 990

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 991  EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 1046

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 1047 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 1099

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 1100 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 1159

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 1160 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 1219

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 1220 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 1277

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 1278 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 1337

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 1396

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 1397 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 1456

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 1457 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 1515

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 1516 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 1575

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 1576 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 1624

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 1625 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 1661



 Score =  117 bits (294), Expect = 2e-25
 Identities = 324/1652 (19%), Positives = 641/1652 (38%), Gaps = 300/1652 (18%)

Query: 311  LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
            L   ++ L+EV   L + E    EQ+ +   +    + + +       L+  +S V  V+
Sbjct: 127  LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS-------LSEVKSEVEMVI 179

Query: 371  QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQ 428
            + G Q++ +     E   E+ E++T L   +  L  +  +R+ +L   L   +K  K++ 
Sbjct: 180  KTGRQIVQKK--QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 237

Query: 429  QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVD 488
             L+ WL  T+  + K     ++    +L   +   K+ Q ++E ++V + S+T +   + 
Sbjct: 238  VLTEWLAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 295

Query: 489  ENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL-----------QEINILWQELLEE 537
               G+  T ++ED+L  L   W AV    EE  N L           Q ++ + + +++ 
Sbjct: 296  TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 354

Query: 538  QCLL----KAWLTEKEEALNKVQTS---------NFKDQK-----------------ELS 567
              LL    K    +KE+ L +++           + +DQ                  ++S
Sbjct: 355  DTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 414

Query: 568  VSVRRLAILKEDMEMKRQT--LDQLSEIGQDVGQLLDNSKA-------------SKKINS 612
                R A +   ++  + +  L +L +   D+ +LL+  +A             +K +N 
Sbjct: 415  ELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474

Query: 613  DSE----ELTQRWDSLVQRLEDSSNQVTQAVAK--LGMSQIPQKDLLETVRVREQAIT-- 664
            D+E    EL QR D+L QR+ D   +    + +  L       KDL    R +   I+  
Sbjct: 475  DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQ 534

Query: 665  ------------------KKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKW 706
                              +K    LP P   +K +  +D E +KK + ++A         
Sbjct: 535  WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK-EIDRELQKKKEELNAVR------- 586

Query: 707  KTAIQTTEIKEYMKMQDTS-EMKKKLKALEKE--QRERIPRAD---ELNQTGQILVEQMG 760
            + A   +E    M ++ T  ++ K+ + +E +  Q  R+  A       +T  ++ E M 
Sbjct: 587  RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM- 645

Query: 761  KEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEW 820
                   EI  V     +E  +VSQ L      +++++ +NA      + E + K +E  
Sbjct: 646  -----PLEISYVPSTYLTEITHVSQAL------LEVEQLLNAPDLCAKDFEDLFKQEE-- 692

Query: 821  VKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFD 880
                        SL ++KDS Q+    +  +H K   A  S +     P     +Q    
Sbjct: 693  ------------SLKNIKDSLQQSSGRIDIIHSKKTAALQSAT-----PVERVKLQEALS 735

Query: 881  SFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSE---NKAQVSLNVL 937
                +++ V +  +DRQ   +  ++      Y   +K     L ++E    K Q+  N  
Sbjct: 736  QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY--DIKIFNQWLTEAEQFLRKTQIPENW- 792

Query: 938  NDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKW 997
             + AK +  L+E +  D I + Q       A   + ++++   D   + +++   +  +W
Sbjct: 793  -EHAKYKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQEKLGSLNLRW 848

Query: 998  NKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLD 1057
             ++   +S     LEE    L  F+ D      W++   D +       G +  L+ +L+
Sbjct: 849  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLE 907

Query: 1058 QCSAFVNEIETIESSLKNMKEIETNLRSGPV---AGIKTWVQTRLGDYQTQLEKLSKEIA 1114
            Q    V E+   +  LK + E       GPV   A I    Q +L   + +L++ + +  
Sbjct: 908  QVKLLVEELPLRQGILKQLNE-----TGGPVLVSAPISPEEQDKL---ENKLKQTNLQWI 959

Query: 1115 TQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSP--EELESAVEEMKRAK 1172
                 L E Q +     KDL ++++ +   EE+ L     + SP   +LE   +  +   
Sbjct: 960  KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ-LNHLLLWLSPIRNQLEIYNQPNQEGP 1018

Query: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
             DV + E+ V+  + +++ + +K    GQ L  E        +     ++ K   L   W
Sbjct: 1019 FDVQETEIAVQAKQPDVEEILSK----GQHLYKE--------KPATQPVKRKLEDLSSEW 1066

Query: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRE 1292
                 LL             E R K  ++ P  T       +++  V +      T I  
Sbjct: 1067 KAVNRLLQ------------ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI-- 1112

Query: 1293 LGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQES 1352
                             KLE  +S   ++  LA+  +   E     L   DQ+++  +  
Sbjct: 1113 ----------------SKLEMPSSLMLEVPALADFNRAWTE-LTDWLSLLDQVIKSQRVM 1155

Query: 1353 LGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTAR 1412
            +G+L+      +  +     + Q   +++  I+A +  L+    N  ++ + +   R  R
Sbjct: 1156 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ-NLKNKTSNQEARTIIT--DRIER 1212

Query: 1413 GGSQMDVLQRKLREVSTKF-QLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI 1471
              +Q D +Q  L+    +  ++ +    + +   + ++VL   +A+L          D I
Sbjct: 1213 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1272

Query: 1472 QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQ 1531
            Q  + +  +L K L + +  V+        +++    D+ + +     ++   +  +  +
Sbjct: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332

Query: 1532 VTEGKQDLERASQLARKMKKEAASLSEWLSATET--ELVQKST-SEGLLGDLDTEISWAK 1588
            V+E +  LE   +L ++   +      WL+  ET   ++Q +T  E LL D       +K
Sbjct: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED-------SK 1385

Query: 1589 NVLKDLEKRKADL-----------NTITESSAALQNLIEGSEP--ILEERLCVLNAGWSR 1635
             V K+L K+  DL           + + E+S  +   +EGS+   +L+ RL  +N  WS 
Sbjct: 1386 GV-KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 1444

Query: 1636 VRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVS 1695
            +R  + +  + L    +Q +    ++  +  WL                K +E+ ++   
Sbjct: 1445 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL--------------QLKDDELSRQAPI 1490

Query: 1696 ELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEP 1755
              D   +Q +N                         +++R F++        +L   +  
Sbjct: 1491 GGDFPAVQKQN-------------------------DVHRAFKR--------ELKTKEPV 1517

Query: 1756 LYQCLVTTETFETGVPFSDLEKL---------ENDIENMLKFVEKHLES-SDEDEKMDEE 1805
            +   L T   F T  P   LEKL         E   +N+ + + K  E  + E EK++  
Sbjct: 1518 IMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLH 1577

Query: 1806 SA----QIEEVLQRGEEMLHQPMEDNKKEKIR 1833
            SA    +I+E L+R +E+  Q   D    K+R
Sbjct: 1578 SADWQRKIDETLERLQEL--QEATDELDLKLR 1607



 Score =  108 bits (270), Expect = 9e-23
 Identities = 296/1599 (18%), Positives = 627/1599 (39%), Gaps = 209/1599 (13%)

Query: 623  SLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAIT--KKSKQELPPPPPPKKR 680
            +L + L +  ++V + V K G  QI QK   E  +  ++ +T  K    EL      +K+
Sbjct: 163  NLYKSLSEVKSEV-EMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 220

Query: 681  QIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRE 740
            Q+   ++  +K       L  W+      +      E M     SE+    KA +KE  +
Sbjct: 221  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEK 279

Query: 741  RIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLED-LERKIQLQED 799
            +      + + G+ L   +GK+    E+  ++L   +S W  V+   E+ L   ++ Q+ 
Sbjct: 280  QKVHLKSITEVGEALKTVLGKKETLVEDKLSLL---NSNWIAVTSRAEEWLNLLLEYQKH 336

Query: 800  INAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMAR 859
            +  + + +D + K I   +     T + ES ++     +D  +R    L  + PK++  R
Sbjct: 337  METFDQNVDHITKWIIQAD-----TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTR 391

Query: 860  ASCSALMSQPS--APDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLK 917
               + LM+         V+        R+ A+   ++  +  +       P     +   
Sbjct: 392  DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-------PLKELEQFNS 444

Query: 918  TLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKN 977
             ++ +L   E + Q  +N+  +    +     + T+ E+L+       ++ +E K  E  
Sbjct: 445  DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 504

Query: 978  VHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKD 1037
            +        KQ+   +Q K N LK L S+      EI+     ++  +  + K +D ++ 
Sbjct: 505  I--------KQQL--LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 554

Query: 1038 FLMKQQAAQGD------DAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGI 1091
             L      + +      D  LQ++ ++ +A   + E +      M    T ++       
Sbjct: 555  KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS----- 609

Query: 1092 KTW--VQTRLGDYQ----TQLEKLSKE---IATQKSRLSESQEKAANLKKDLAEMQEWMT 1142
            K W  ++++   ++     Q+  + +E   + T+   L  S   +  L  ++  + + + 
Sbjct: 610  KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT-EITHVSQALL 668

Query: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDN-IKLLAAKVPSGG- 1200
            + E+     D   K  E+L    E +K  K+ + Q   R+ I+       L +  P    
Sbjct: 669  EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 728

Query: 1201 --QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY-LDLETTWLNTLEERMK 1257
              QE  S+L+   E    +    +G+     E W       HY + +   WL   E+ ++
Sbjct: 729  KLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW----RRFHYDIKIFNQWLTEAEQFLR 784

Query: 1258 STEVLPEKTDAVNEA--LESLESVLRHPADNRTQIREL---GQTLIDGGILDD--IISEK 1310
             T++ PE  +       L+ L+  +      +T +R L   G+ +I      D  I+ EK
Sbjct: 785  KTQI-PENWEHAKYKWYLKELQDGI---GQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840

Query: 1311 LEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDA 1370
            L + N R++++      ++  LE+Q  +L E  + L      L E D   +  L      
Sbjct: 841  LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE----- 895

Query: 1371 FQVPQEAQKIQAEISAHELTLEE--LRRNMRSQ--------PLTSPESRTARGGSQMDVL 1420
               P + Q+++ ++   +L +EE  LR+ +  Q         +++P S   +   +  + 
Sbjct: 896  ---PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 952

Query: 1421 QRKLREVSTKFQLFQKPANFEQRMLD---CKRVLDGVKAELHVL-----DVKDVDPDVIQ 1472
            Q  L+ +     L +K    E ++ D    ++ L+ ++ +L+ L      +++      Q
Sbjct: 953  QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1012

Query: 1473 THLDKCMKLYKTLSEVKL---EVETVIKTGRHIVQKQQTDNP------------KGMDEQ 1517
             + +    + +T   V+    +VE ++  G+H+ +++    P            K ++  
Sbjct: 1013 PNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRL 1072

Query: 1518 LTSLKVLYNDL-------GAQVTE--------------GKQDLERASQLARKMKKEA--- 1553
            L  L+    DL       GA  T+                  LE  S L  ++   A   
Sbjct: 1073 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 1132

Query: 1554 ---ASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAA 1610
                 L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  
Sbjct: 1133 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1192

Query: 1611 LQNLIEGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIF 1657
            L+N     E   I+ +R+  +   W  V+   ++     N ++    Q         ++ 
Sbjct: 1193 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1252

Query: 1658 DGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNA 1717
                A + +W  +    +D I+KK T       K+L  +L      V+   D AL L+  
Sbjct: 1253 GQARAKLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRD 1306

Query: 1718 RGSSSRELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDL 1775
              +     V      +N ++  + + +  + A L      L Q  +  E F   +  ++ 
Sbjct: 1307 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEA 1364

Query: 1776 EKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
            E   N +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+
Sbjct: 1365 ETTANVLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 1423

Query: 1836 ----LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMD 1884
                 +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + 
Sbjct: 1424 GSDDAVLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 1480

Query: 1885 DVELSLNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVIL 1936
            D ELS   P        +    ++  F   +  LK  +  +    E + +   +QP   L
Sbjct: 1481 DDELSRQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGL 1537

Query: 1937 EASGPEAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHC 1983
            E    E  +             +R    ++N +W+++N   +D +   D  +E  ++   
Sbjct: 1538 EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597

Query: 1984 DLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIV 2043
              ++L   + +A E++  +  P G L ++  + H ++++       P    ++   D + 
Sbjct: 1598 ATDELDLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LA 1655

Query: 2044 QKLSQAD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
            ++L+        +    L  LN RW  +   V+DR  +L
Sbjct: 1656 RQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 1694



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 1334 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1393

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 1394 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 1510

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 1681

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 1682 LLQVAVEDRVRQLHEAHRDFG 1702



 Score = 35.4 bits (80), Expect = 0.98
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 719  MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
            ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 2154 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 2213

Query: 776  VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
            + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 2214 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 2273

Query: 835  PSLKDSCQRELTNLLG 850
                DS Q  L  ++G
Sbjct: 2274 LQRSDSSQPMLLRVVG 2289



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 1510 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 1567

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 1568 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 1627

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 1628 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 1684

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 1685 VAVEDRVRQLHE 1696


>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
          Length = 2344

 Score = 1558 bits (4034), Expect = 0.0
 Identities = 930/2372 (39%), Positives = 1392/2372 (58%), Gaps = 118/2372 (4%)

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 24   LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 78

Query: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 79   HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 131

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 132  -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 186

Query: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 187  QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 246

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 247  AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 302

Query: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 303  KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362

Query: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 363  ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 422

Query: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 423  FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 481

Query: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 482  TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 541

Query: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 542  KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 592

Query: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 593  EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 644

Query: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 645  TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 702

Query: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 703  SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 762

Query: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 763  EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 816

Query: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 817  VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 876

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 877  RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 935

Query: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 936  VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 995

Query: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 996  LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 1052

Query: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 1053 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 1112

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 1113 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 1169

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 1170 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 1229

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 1230 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 1289

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 1290 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 1349

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 1350 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 1409

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 1410 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 1469

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 1470 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 1529

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 1530 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 1586

Query: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 1587 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 1646

Query: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 1647 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 1706

Query: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 1707 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 1766

Query: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 1767 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 1826

Query: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 1827 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 1886

Query: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 1887 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 1946

Query: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 1947 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 2006

Query: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 2007 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 2066

Query: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 2067 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 2126

Query: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 2127 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 2186

Query: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 2187 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 2246

Query: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 2247 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 2306

Query: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 2307 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 2338



 Score =  525 bits (1353), Expect = e-148
 Identities = 426/1574 (27%), Positives = 768/1574 (48%), Gaps = 211/1574 (13%)

Query: 1325 AESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384
            A  +Q  LE+ +Q  +ET++ L ++QESL  +DKQL  Y+ D++DA Q+PQEAQKIQ+++
Sbjct: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76

Query: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRM 1444
            ++HE++LEE++++ + +          R  SQ+DV Q+KL++VS KF+LFQKPANFEQR+
Sbjct: 77   TSHEISLEEMKKHNQGKEAAQ------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 130

Query: 1445 LDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQ 1504
             + K +LD VK  L  L+ K V+ +V+Q+ L+ C+ LYK+LSEVK EVE VIKTGR IVQ
Sbjct: 131  QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 190

Query: 1505 KQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564
            K+QT+NPK +DE++T+LK+ YN+LGA+VTE KQ LE+  +L+RKM+KE   L+EWL+AT+
Sbjct: 191  KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250

Query: 1565 TELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEE 1624
             EL ++S  EG+  +LD+E++W K   K++EK+K  L +ITE   AL+ ++   E ++E+
Sbjct: 251  MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVED 310

Query: 1625 RLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTS 1684
            +L +LN+ W  V +  E+W N L+ +Q  +E FD NV HI+ W+ QA+ LLDE EKK   
Sbjct: 311  KLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ 370

Query: 1685 KQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHI 1744
            ++E+++KRL +EL+D   +V++ RDQA  LM  RG   R+LVEP+++ELN  F  +S  I
Sbjct: 371  QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 430

Query: 1745 KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEK------HLESSDE 1798
            K+ K                     +P  +LE+  +DI+ +L+ +E       +L+  D 
Sbjct: 431  KTGK-------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF 471

Query: 1799 DEKMDEES-AQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857
            ++ M+E++   ++E+LQRG+ +  +  ++ K+E+I+++  LL T++N +K +  Q+RK  
Sbjct: 472  NKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK-- 529

Query: 1858 QLASGIRSSLLPTDYLVEINKILLCMDDVELSL-NVPELNTAIYEDFSFQEDSLKNIKDQ 1916
                 +  S     Y  + + +L C+DD+E  L ++PE            E  +K I  +
Sbjct: 530  ---KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR---------DERKIKEIDRE 577

Query: 1917 LDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAME 1976
            L K  E++  +  +   +  + +   A+ +  T  QL+ +W  I   ++  +      + 
Sbjct: 578  LQKKKEELNAVRRQAEGLSEDGA---AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634

Query: 1977 EWRQ--------------------FHCDLNDLTQWITEAEELL--VDTCAPGGSLDLEKA 2014
              R+                    +  ++  ++Q + E E+LL   D CA     DL K 
Sbjct: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE-DLFKQ 693

Query: 2015 RIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKD 2074
                + ++  +         ++      +Q  +  +   L+E L+ L+ +W+ +    KD
Sbjct: 694  EESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKD 753

Query: 2075 RQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQ---ELRDLTQEMEV 2131
            RQ R     ++  ++ + +     WLT+AE  ++K    E  E+ +    L++L   +  
Sbjct: 754  RQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQ 813

Query: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
                ++ LN T  E++   S +  +   + E L ++N+ W ++C+++    K   ++ + 
Sbjct: 814  RQTVVRTLNATGEEIIQQSSKT--DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI 871

Query: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251
            +S+ +     ++ + VL    +D        +  SIP +  K            +Q LK 
Sbjct: 872  LSEFQ----RDLNEFVLWLEEAD--------NIASIPLEPGK------------EQQLKE 907

Query: 2252 NIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLE 2311
             +      E++   V  + + +  L+Q +       T    L +   S + +  +  KL+
Sbjct: 908  KL------EQVKLLVEELPLRQGILKQLNE------TGGPVLVSAPISPEEQDKLENKLK 955

Query: 2312 RVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR-------KYEARLYILQQ 2364
            +   QW      +  +Q ++E  I D  Q +   E+ EE +            +L I  Q
Sbjct: 956  QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1015

Query: 2365 ARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW 2424
              ++     + + +I +Q   P    +++    L K         T+ VK   E L + W
Sbjct: 1016 PNQEG-PFDVQETEIAVQAKQPDVEEILSKGQHLYK-----EKPATQPVKRKLEDLSSEW 1069

Query: 2425 --IN-LKQSIADRQNALEAEWRTVQASRRDLENFL-KWIQEAETTVN------------- 2467
              +N L Q +  +Q  L     T+ AS       + + +   ET ++             
Sbjct: 1070 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 1129

Query: 2468 VLVDASHRENALQD--SILARELKQQ------MQDIQAEIDAHNDIFKSIDGNR------ 2513
             L D +     L D  S+L + +K Q      ++DI   I       + ++  R      
Sbjct: 1130 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 1189

Query: 2514 ----QKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLE 2569
                Q +     N E  T++  R++ +  +W++       ++ HL+   ++ N +   L+
Sbjct: 1190 ITAAQNLKNKTSNQEARTIITDRIERIQNQWDE-------VQEHLQNRRQQLNEM---LK 1239

Query: 2570 ELIKWLNMKDE------------ELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVL 2617
            +  +WL  K+E            E  K+ P    V A+Q +    K L ++L++ + +V 
Sbjct: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPY--TVDAIQKKITETKQLAKDLRQWQTNVD 1297

Query: 2618 NAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNA 2677
             A D A   L D       +  R +   T     E      +++ K+ SE +   E  + 
Sbjct: 1298 VANDLALKLLRDY----SADDTRKVHMIT-----ENINASWRSIHKRVSEREAALEETHR 1348

Query: 2678 VTSNWQKQVDKALEKLRDLQGAMDDL-DADMKE-----AESVRNGWKPVGDL-------- 2723
            +   +   ++K L  L + +   + L DA  KE     ++ V+   K   DL        
Sbjct: 1349 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1408

Query: 2724 -LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
             +  +L ++ +KI+   E         + +++++ + S L    SL +   L+  + +WK
Sbjct: 1409 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL-RKKSLNIRSHLEASSDQWK 1467

Query: 2783 LLQVSVDDRLKQLQ 2796
             L +S+ + L  LQ
Sbjct: 1468 RLHLSLQELLVWLQ 1481



 Score =  137 bits (346), Expect = 1e-31
 Identities = 333/1726 (19%), Positives = 656/1726 (38%), Gaps = 264/1726 (15%)

Query: 887  QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA 946
            Q +Q  +   +  LE   K   G    + + +  DV         +   +    A  E+ 
Sbjct: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQR 129

Query: 947  LQEKKTLDEILENQKPALHKLAEETKALEKN-------------VHPDVEKLYKQEFDDV 993
            LQE K + + ++   PAL   + E + ++               V  +VE + K     V
Sbjct: 130  LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 189

Query: 994  QGK------------------WNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGV 1035
            Q K                  +N+L   V++    LE+     R    +  V+ +W+   
Sbjct: 190  QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 249

Query: 1036 KDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIK-TW 1094
               L K+ A +G  + L  ++    A   EIE  +  LK++ E+   L++  V G K T 
Sbjct: 250  DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETL 307

Query: 1095 VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154
            V+ +L    +    ++       + L E Q+      +++  + +W+ QA+   L  + E
Sbjct: 308  VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT--LLDESE 365

Query: 1155 YKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELT----SELNVV 1210
             K P++ E  ++ +K    D+  K   V   +D    L A      ++L     SELN  
Sbjct: 366  KKKPQQKEDVLKRLKAELNDIRPK---VDSTRDQAANLMANRGDHCRKLVEPQISELN-- 420

Query: 1211 LENYQLLCNRIR-GKC----HTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEK 1265
               +  + +RI+ GK       LE+  S   +LL  L+ E      L+E   + ++  + 
Sbjct: 421  -HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDN 479

Query: 1266 TDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLA 1325
               V E L+  +++ +   D R +  E+            I  + L+  ++  +DL    
Sbjct: 480  EGTVKELLQRGDNLQQRITDERKR-EEI-----------KIKQQLLQTKHNALKDLRSQR 527

Query: 1326 ESKQISLEKQ-LQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384
              K + +  Q  Q  R+ D +L+ L     +++K+L +    R +     ++ ++I  E+
Sbjct: 528  RKKALEISHQWYQYKRQADDLLKCLD----DIEKKLASLPEPRDE-----RKIKEIDREL 578

Query: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF---- 1440
               +  L  +RR  +++ L+   +  A   +Q+  L ++ RE+ +KF  F++  NF    
Sbjct: 579  QKKKEELNAVRR--QAEGLSEDGAAMAVEPTQIQ-LSKRWREIESKFAQFRR-LNFAQIH 634

Query: 1441 -----------EQRMLDCKRVLDGVKAEL-HV----LDVKDV--DPDVIQTHLDKCMKLY 1482
                       E   L+   V      E+ HV    L+V+ +   PD+     +   K  
Sbjct: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 694

Query: 1483 KTLSEVKLEVETVIKTGR-HIVQKQQTDNPKG--------MDEQLTSLKVLYNDLGAQVT 1533
            ++L  +K  ++    +GR  I+  ++T   +         + E L+ L   +  +     
Sbjct: 695  ESLKNIKDSLQQ--SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 752

Query: 1534 EGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKD 1593
            + +   +R+ +  R+   +    ++WL+  E  L +    E      + E +  K  LK+
Sbjct: 753  DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE------NWEHAKYKWYLKE 806

Query: 1594 LEKRKADLNTITES-SAALQNLIEGSE----PILEERLCVLNAGWSRVRTWTEDWCNTLM 1648
            L+       T+  + +A  + +I+ S      IL+E+L  LN  W  V     D    L 
Sbjct: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 866

Query: 1649 NHQNQLEIFDGNVAHISTWLYQAEAL----LDEIEKKPTSKQEEIVKRLVSELD--DANL 1702
              +N L  F  ++     WL +A+ +    L+  +++   ++ E VK LV EL      L
Sbjct: 867  EQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 926

Query: 1703 QVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVT 1762
            +  N     +++        ++ +E KL + N  + KVS+ +          P  Q  + 
Sbjct: 927  KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL----------PEKQGEIE 976

Query: 1763 TETFETGVPFSDLEKLENDIENMLKFV---------------EKHLESSDEDEKMDEESA 1807
             +  + G     LE LE  + ++L ++               E   +  + +  +  +  
Sbjct: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036

Query: 1808 QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR-KMGQLASGIRS- 1865
             +EE+L +G+   H   E    + ++ +L  L + +  +  +  + R K   LA G+ + 
Sbjct: 1037 DVEEILSKGQ---HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093

Query: 1866 SLLPTDYLVEINKILLCMDDVELSLNVPE---LNTAIYEDFSFQEDSLKN--------IK 1914
               PT  +  + + ++  +     L +P    L      DF+     L +        IK
Sbjct: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1153

Query: 1915 DQLDKLGE----QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAK----------WDRI 1960
             Q   +G+       +I +K     LE   P+  ++      L  K           DRI
Sbjct: 1154 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1213

Query: 1961 NRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWI---TEAEELLVDTCA--------PGGSL 2009
             R+ +      +      +Q +  L D TQW+    EAE++L    A        P    
Sbjct: 1214 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1273

Query: 2010 DLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIV 2069
             ++K     ++L   +   Q +    N     +++  S  D   +      +N  W +I 
Sbjct: 1274 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333

Query: 2070 AEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAMQKRSTTELGENLQEL 2122
              V +R+  L+   + + ++   L++ + WLT+AE        A +K    E  + ++EL
Sbjct: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393

Query: 2123 ----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERDKISESLRTVNMTWNK 2173
                +DL  E+E H +    L+    ++L     SD ++ L  R      L  +N  W++
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR------LDNMNFKWSE 1447

Query: 2174 ICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDK 2233
            + ++                                     + ++SH  +       L  
Sbjct: 1448 LRKK------------------------------------SLNIRSHLEASSDQWKRLHL 1471

Query: 2234 TITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNL 2293
            ++ EL  WL L D  L       GD   + K     +  K +L+ + P +       +  
Sbjct: 1472 SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIF 1531

Query: 2294 KNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR 2353
              +     +     E  E      +  Q+   L ++Q E++   + +W+     + +  R
Sbjct: 1532 LTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---NTEWEKLNLHSADWQR 1586

Query: 2354 KYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFDNVLQKLLEEYG---- 2406
            K +  L  LQ  Q   D L  ++   +++     P GD ++ +  + L+K+    G    
Sbjct: 1587 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 1646

Query: 2407 -SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRD 2451
              ++  +V +    L T  I L          L   W+ +Q +  D
Sbjct: 1647 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 1692



 Score =  133 bits (334), Expect = 3e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631

Query: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 632  QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 688

Query: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 689  --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 746

Query: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 747  VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 804

Query: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862

Query: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 863  KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 920

Query: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 921  LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977

Query: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
             +  LG  +   +DL                                             
Sbjct: 978  QIKDLGQLEKKLEDL--------------------------------------------E 993

Query: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 994  EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 1049

Query: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 1050 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 1102

Query: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 1103 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162

Query: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 1222

Query: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 1223 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 1280

Query: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 1281 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 1340

Query: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 1399

Query: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 1400 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 1459

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 1460 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 1518

Query: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 1519 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 1578

Query: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 1579 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 1627

Query: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 1628 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 1664



 Score =  117 bits (294), Expect = 2e-25
 Identities = 324/1652 (19%), Positives = 641/1652 (38%), Gaps = 300/1652 (18%)

Query: 311  LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
            L   ++ L+EV   L + E    EQ+ +   +    + + +       L+  +S V  V+
Sbjct: 130  LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS-------LSEVKSEVEMVI 182

Query: 371  QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQ 428
            + G Q++ +     E   E+ E++T L   +  L  +  +R+ +L   L   +K  K++ 
Sbjct: 183  KTGRQIVQKK--QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 240

Query: 429  QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVD 488
             L+ WL  T+  + K     ++    +L   +   K+ Q ++E ++V + S+T +   + 
Sbjct: 241  VLTEWLAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 298

Query: 489  ENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL-----------QEINILWQELLEE 537
               G+  T ++ED+L  L   W AV    EE  N L           Q ++ + + +++ 
Sbjct: 299  TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 357

Query: 538  QCLL----KAWLTEKEEALNKVQTS---------NFKDQK-----------------ELS 567
              LL    K    +KE+ L +++           + +DQ                  ++S
Sbjct: 358  DTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 417

Query: 568  VSVRRLAILKEDMEMKRQT--LDQLSEIGQDVGQLLDNSKA-------------SKKINS 612
                R A +   ++  + +  L +L +   D+ +LL+  +A             +K +N 
Sbjct: 418  ELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477

Query: 613  DSE----ELTQRWDSLVQRLEDSSNQVTQAVAK--LGMSQIPQKDLLETVRVREQAIT-- 664
            D+E    EL QR D+L QR+ D   +    + +  L       KDL    R +   I+  
Sbjct: 478  DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQ 537

Query: 665  ------------------KKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKW 706
                              +K    LP P   +K +  +D E +KK + ++A         
Sbjct: 538  WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK-EIDRELQKKKEELNAVR------- 589

Query: 707  KTAIQTTEIKEYMKMQDTS-EMKKKLKALEKE--QRERIPRAD---ELNQTGQILVEQMG 760
            + A   +E    M ++ T  ++ K+ + +E +  Q  R+  A       +T  ++ E M 
Sbjct: 590  RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM- 648

Query: 761  KEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEW 820
                   EI  V     +E  +VSQ L      +++++ +NA      + E + K +E  
Sbjct: 649  -----PLEISYVPSTYLTEITHVSQAL------LEVEQLLNAPDLCAKDFEDLFKQEE-- 695

Query: 821  VKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFD 880
                        SL ++KDS Q+    +  +H K   A  S +     P     +Q    
Sbjct: 696  ------------SLKNIKDSLQQSSGRIDIIHSKKTAALQSAT-----PVERVKLQEALS 738

Query: 881  SFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSE---NKAQVSLNVL 937
                +++ V +  +DRQ   +  ++      Y   +K     L ++E    K Q+  N  
Sbjct: 739  QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY--DIKIFNQWLTEAEQFLRKTQIPENW- 795

Query: 938  NDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKW 997
             + AK +  L+E +  D I + Q       A   + ++++   D   + +++   +  +W
Sbjct: 796  -EHAKYKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQEKLGSLNLRW 851

Query: 998  NKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLD 1057
             ++   +S     LEE    L  F+ D      W++   D +       G +  L+ +L+
Sbjct: 852  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLE 910

Query: 1058 QCSAFVNEIETIESSLKNMKEIETNLRSGPV---AGIKTWVQTRLGDYQTQLEKLSKEIA 1114
            Q    V E+   +  LK + E       GPV   A I    Q +L   + +L++ + +  
Sbjct: 911  QVKLLVEELPLRQGILKQLNE-----TGGPVLVSAPISPEEQDKL---ENKLKQTNLQWI 962

Query: 1115 TQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSP--EELESAVEEMKRAK 1172
                 L E Q +     KDL ++++ +   EE+ L     + SP   +LE   +  +   
Sbjct: 963  KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ-LNHLLLWLSPIRNQLEIYNQPNQEGP 1021

Query: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
             DV + E+ V+  + +++ + +K    GQ L  E        +     ++ K   L   W
Sbjct: 1022 FDVQETEIAVQAKQPDVEEILSK----GQHLYKE--------KPATQPVKRKLEDLSSEW 1069

Query: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRE 1292
                 LL             E R K  ++ P  T       +++  V +      T I  
Sbjct: 1070 KAVNRLLQ------------ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI-- 1115

Query: 1293 LGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQES 1352
                             KLE  +S   ++  LA+  +   E     L   DQ+++  +  
Sbjct: 1116 ----------------SKLEMPSSLMLEVPALADFNRAWTE-LTDWLSLLDQVIKSQRVM 1158

Query: 1353 LGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTAR 1412
            +G+L+      +  +     + Q   +++  I+A +  L+    N  ++ + +   R  R
Sbjct: 1159 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ-NLKNKTSNQEARTIIT--DRIER 1215

Query: 1413 GGSQMDVLQRKLREVSTKF-QLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI 1471
              +Q D +Q  L+    +  ++ +    + +   + ++VL   +A+L          D I
Sbjct: 1216 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275

Query: 1472 QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQ 1531
            Q  + +  +L K L + +  V+        +++    D+ + +     ++   +  +  +
Sbjct: 1276 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1335

Query: 1532 VTEGKQDLERASQLARKMKKEAASLSEWLSATET--ELVQKST-SEGLLGDLDTEISWAK 1588
            V+E +  LE   +L ++   +      WL+  ET   ++Q +T  E LL D       +K
Sbjct: 1336 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED-------SK 1388

Query: 1589 NVLKDLEKRKADL-----------NTITESSAALQNLIEGSEP--ILEERLCVLNAGWSR 1635
             V K+L K+  DL           + + E+S  +   +EGS+   +L+ RL  +N  WS 
Sbjct: 1389 GV-KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 1447

Query: 1636 VRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVS 1695
            +R  + +  + L    +Q +    ++  +  WL                K +E+ ++   
Sbjct: 1448 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL--------------QLKDDELSRQAPI 1493

Query: 1696 ELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEP 1755
              D   +Q +N                         +++R F++        +L   +  
Sbjct: 1494 GGDFPAVQKQN-------------------------DVHRAFKR--------ELKTKEPV 1520

Query: 1756 LYQCLVTTETFETGVPFSDLEKL---------ENDIENMLKFVEKHLES-SDEDEKMDEE 1805
            +   L T   F T  P   LEKL         E   +N+ + + K  E  + E EK++  
Sbjct: 1521 IMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLH 1580

Query: 1806 SA----QIEEVLQRGEEMLHQPMEDNKKEKIR 1833
            SA    +I+E L+R +E+  Q   D    K+R
Sbjct: 1581 SADWQRKIDETLERLQEL--QEATDELDLKLR 1610



 Score =  108 bits (270), Expect = 9e-23
 Identities = 296/1599 (18%), Positives = 627/1599 (39%), Gaps = 209/1599 (13%)

Query: 623  SLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAIT--KKSKQELPPPPPPKKR 680
            +L + L +  ++V + V K G  QI QK   E  +  ++ +T  K    EL      +K+
Sbjct: 166  NLYKSLSEVKSEV-EMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223

Query: 681  QIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRE 740
            Q+   ++  +K       L  W+      +      E M     SE+    KA +KE  +
Sbjct: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEK 282

Query: 741  RIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLED-LERKIQLQED 799
            +      + + G+ L   +GK+    E+  ++L   +S W  V+   E+ L   ++ Q+ 
Sbjct: 283  QKVHLKSITEVGEALKTVLGKKETLVEDKLSLL---NSNWIAVTSRAEEWLNLLLEYQKH 339

Query: 800  INAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMAR 859
            +  + + +D + K I   +     T + ES ++     +D  +R    L  + PK++  R
Sbjct: 340  METFDQNVDHITKWIIQAD-----TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTR 394

Query: 860  ASCSALMSQPS--APDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLK 917
               + LM+         V+        R+ A+   ++  +  +       P     +   
Sbjct: 395  DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-------PLKELEQFNS 447

Query: 918  TLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKN 977
             ++ +L   E + Q  +N+  +    +     + T+ E+L+       ++ +E K  E  
Sbjct: 448  DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 507

Query: 978  VHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKD 1037
            +        KQ+   +Q K N LK L S+      EI+     ++  +  + K +D ++ 
Sbjct: 508  I--------KQQL--LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 557

Query: 1038 FLMKQQAAQGD------DAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGI 1091
             L      + +      D  LQ++ ++ +A   + E +      M    T ++       
Sbjct: 558  KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS----- 612

Query: 1092 KTW--VQTRLGDYQ----TQLEKLSKE---IATQKSRLSESQEKAANLKKDLAEMQEWMT 1142
            K W  ++++   ++     Q+  + +E   + T+   L  S   +  L  ++  + + + 
Sbjct: 613  KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT-EITHVSQALL 671

Query: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDN-IKLLAAKVPSGG- 1200
            + E+     D   K  E+L    E +K  K+ + Q   R+ I+       L +  P    
Sbjct: 672  EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 731

Query: 1201 --QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY-LDLETTWLNTLEERMK 1257
              QE  S+L+   E    +    +G+     E W       HY + +   WL   E+ ++
Sbjct: 732  KLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW----RRFHYDIKIFNQWLTEAEQFLR 787

Query: 1258 STEVLPEKTDAVNEA--LESLESVLRHPADNRTQIREL---GQTLIDGGILDD--IISEK 1310
             T++ PE  +       L+ L+  +      +T +R L   G+ +I      D  I+ EK
Sbjct: 788  KTQI-PENWEHAKYKWYLKELQDGI---GQRQTVVRTLNATGEEIIQQSSKTDASILQEK 843

Query: 1311 LEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDA 1370
            L + N R++++      ++  LE+Q  +L E  + L      L E D   +  L      
Sbjct: 844  LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE----- 898

Query: 1371 FQVPQEAQKIQAEISAHELTLEE--LRRNMRSQ--------PLTSPESRTARGGSQMDVL 1420
               P + Q+++ ++   +L +EE  LR+ +  Q         +++P S   +   +  + 
Sbjct: 899  ---PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 955

Query: 1421 QRKLREVSTKFQLFQKPANFEQRMLD---CKRVLDGVKAELHVL-----DVKDVDPDVIQ 1472
            Q  L+ +     L +K    E ++ D    ++ L+ ++ +L+ L      +++      Q
Sbjct: 956  QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1015

Query: 1473 THLDKCMKLYKTLSEVKL---EVETVIKTGRHIVQKQQTDNP------------KGMDEQ 1517
             + +    + +T   V+    +VE ++  G+H+ +++    P            K ++  
Sbjct: 1016 PNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRL 1075

Query: 1518 LTSLKVLYNDL-------GAQVTE--------------GKQDLERASQLARKMKKEA--- 1553
            L  L+    DL       GA  T+                  LE  S L  ++   A   
Sbjct: 1076 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 1135

Query: 1554 ---ASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAA 1610
                 L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  
Sbjct: 1136 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1195

Query: 1611 LQNLIEGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIF 1657
            L+N     E   I+ +R+  +   W  V+   ++     N ++    Q         ++ 
Sbjct: 1196 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1255

Query: 1658 DGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNA 1717
                A + +W  +    +D I+KK T       K+L  +L      V+   D AL L+  
Sbjct: 1256 GQARAKLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRD 1309

Query: 1718 RGSSSRELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDL 1775
              +     V      +N ++  + + +  + A L      L Q  +  E F   +  ++ 
Sbjct: 1310 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEA 1367

Query: 1776 EKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
            E   N +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+
Sbjct: 1368 ETTANVLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 1426

Query: 1836 ----LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMD 1884
                 +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + 
Sbjct: 1427 GSDDAVLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 1483

Query: 1885 DVELSLNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVIL 1936
            D ELS   P        +    ++  F   +  LK  +  +    E + +   +QP   L
Sbjct: 1484 DDELSRQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGL 1540

Query: 1937 EASGPEAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHC 1983
            E    E  +             +R    ++N +W+++N   +D +   D  +E  ++   
Sbjct: 1541 EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1600

Query: 1984 DLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIV 2043
              ++L   + +A E++  +  P G L ++  + H ++++       P    ++   D + 
Sbjct: 1601 ATDELDLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LA 1658

Query: 2044 QKLSQAD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
            ++L+        +    L  LN RW  +   V+DR  +L
Sbjct: 1659 RQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 1697



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396

Query: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 1397 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455

Query: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 1513

Query: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573

Query: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1633

Query: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 1634 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 1684

Query: 623  SLVQRLEDSSNQVTQAVAKLG 643
             L   +ED   Q+ +A    G
Sbjct: 1685 LLQVAVEDRVRQLHEAHRDFG 1705



 Score = 42.4 bits (98), Expect = 0.008
 Identities = 82/467 (17%), Positives = 183/467 (39%), Gaps = 55/467 (11%)

Query: 2360 YILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSD--DTRNVKETT 2417
            Y L   RR  L +Q   +    QE      ++      + K L  Y +D  D   + +  
Sbjct: 13   YFLNAVRRQKLLEQSIQSA---QETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA 69

Query: 2418 EYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHREN 2477
            + +++   + + S+ + +   + +    Q     ++   K +Q+      +    ++ E 
Sbjct: 70   QKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 128

Query: 2478 ALQDSIL----------ARELKQQMQDI-QAEIDAHNDIFKSIDGNRQK--MVKALGN-- 2522
             LQ+S +          A E K   Q++ Q++++   +++KS+   + +  MV   G   
Sbjct: 129  RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 188

Query: 2523 -----SEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNM 2577
                 +E    L  R+  +   +N+L AK    +  LE   +   ++   +  L +WL  
Sbjct: 189  VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 248

Query: 2578 KDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEY---SVLNAVDQARVFLADQPIEA 2634
             D EL K+  + G    L  +    KA ++E+++++    S+    +  +  L  +  E 
Sbjct: 249  TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK--ET 306

Query: 2635 PEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALE--- 2691
              E + +L +   +    RA++    + +    ++   ++++ +T  W  Q D  L+   
Sbjct: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT-KWIIQADTLLDESE 365

Query: 2692 --KLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEK-----IMAFREEIAP 2744
              K +  +  +  L A++ +     +  +     L+ +  DH  K     I       A 
Sbjct: 366  KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAA 425

Query: 2745 INFKVKT-------------VNDLSSQLSPLDLHPSLKMSRQLDDLN 2778
            I+ ++KT              +D+   L PL+      ++ + +D N
Sbjct: 426  ISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472



 Score = 35.4 bits (80), Expect = 0.98
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 719  MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
            ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 2157 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 2216

Query: 776  VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
            + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 2217 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 2276

Query: 835  PSLKDSCQRELTNLLG 850
                DS Q  L  ++G
Sbjct: 2277 LQRSDSSQPMLLRVVG 2292



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 1513 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 1570

Query: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 1571 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 1630

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 1631 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 1687

Query: 406  VESMDRQSRLHD 417
            V   DR  +LH+
Sbjct: 1688 VAVEDRVRQLHE 1699


>gi|5032293 dystrophin Dp140 isoform [Homo sapiens]
          Length = 1225

 Score = 1483 bits (3839), Expect = 0.0
 Identities = 733/1215 (60%), Positives = 933/1215 (76%), Gaps = 11/1215 (0%)

Query: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
            E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ + + K T  DLEQR PQL
Sbjct: 8    EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 67

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
            + + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ R+QQL +M+ DS QW +
Sbjct: 68   EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 127

Query: 2344 HREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             +EE E+++ +  A+L   ++     D + K+I++ + L ++L      V   +++  KL
Sbjct: 128  AKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 187

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
            L +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R +Q    DLE FL W+ E
Sbjct: 188  LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 2462 AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALG 2521
            AETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D++ ++D N QK++++L 
Sbjct: 248  AETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 307

Query: 2522 NSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEE 2581
             S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL +SL+EL+ WL +KD+E
Sbjct: 308  GSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 367

Query: 2582 LKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRN 2641
            L +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R+FL +QP+E  E   + 
Sbjct: 368  LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE---KL 424

Query: 2642 LQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD 2701
             Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+++D+ LE+L++LQ A D
Sbjct: 425  YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 484

Query: 2702 DLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
            +LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP+   V  VNDL+ QL+ 
Sbjct: 485  ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 544

Query: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821
            L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 604

Query: 2822 ISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLL 2881
            IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL
Sbjct: 605  ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 664

Query: 2882 ELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLN 2941
             LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLN
Sbjct: 665  SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 724

Query: 2942 VYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQI 3001
            VYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQI
Sbjct: 725  VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 784

Query: 3002 PRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAA 3061
            PRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAA
Sbjct: 785  PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 844

Query: 3062 ETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTT 3121
            ETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTT
Sbjct: 845  ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 904

Query: 3122 SGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQ 3181
            SGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ETP+TLI+ WP    P+ 
Sbjct: 905  SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPAS 964

Query: 3182 SPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESP 3241
            SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP
Sbjct: 965  SPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSP 1024

Query: 3242 VSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPE 3300
            +SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE
Sbjct: 1025 LSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPE 1084

Query: 3301 SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS 3360
             + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++
Sbjct: 1085 MMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEA 1144

Query: 3361 RINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIH 3416
            ++NG    SP  S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++
Sbjct: 1145 KVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLN 1204

Query: 3417 STFPSC-CPNVPSRP 3430
            ++FPS    N P +P
Sbjct: 1205 NSFPSSRGRNTPGKP 1219



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 117/589 (19%), Positives = 260/589 (44%), Gaps = 68/589 (11%)

Query: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP 743
            +++ A   F+    EL +W+      I++  +     ++D +EM  K KA  ++  +R P
Sbjct: 7    LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 65

Query: 744  RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINA 802
            + +EL    Q L  +   +   T  I + +E++ ++W  V +HL++  +++ ++ +D   
Sbjct: 66   QLEELITAAQNLKNKTSNQEARTI-ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 124

Query: 803  YFKQLDELEKVIKTK----EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858
            + +  +E E+V+       E W +     ++ ++ +   K   +    +L      +++A
Sbjct: 125  WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK----DLRQWQTNVDVA 180

Query: 859  RASCSALMSQPSAPDF--VQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETL 916
                  L+   SA D   V    ++    ++++ + V +R+  LE            ET 
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE------------ETH 228

Query: 917  KTLKDVLNDSEN------KAQVSLNVLNDLAKVEKALQEKKTLDEIL----------ENQ 960
            + L+    D E       +A+ + NVL D  + E+ L++ K + E++          E  
Sbjct: 229  RLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAH 288

Query: 961  KPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLR 1019
                H L E ++ + +++   D   L ++  D++  KW++L+    K L++   +  +  
Sbjct: 289  TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR---KKSLNIRSHLEASSD 345

Query: 1020 AFEADSTVIEK---WMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES-SLKN 1075
             ++     +++   W+    D L +Q    GD   +Q+Q D   AF  E++T E   +  
Sbjct: 346  QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 405

Query: 1076 MKEIETNLRSGPVAGI-KTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEK----AANL 1130
            ++ +   L   P+ G+ K + + R    + + + +++ +  Q   ++   EK    +A+ 
Sbjct: 406  LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 465

Query: 1131 KKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV-RVKILKDNI 1189
            ++ + E  E + + +E   E D + +  E ++ + + +     D LQ  + +VK L+  I
Sbjct: 466  QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEI 525

Query: 1190 KLL---AAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
              L    + V    ++LT+ L + L  Y L          TLE++ + W
Sbjct: 526  APLKENVSHVNDLARQLTT-LGIQLSPYNL---------STLEDLNTRW 564



 Score = 86.3 bits (212), Expect = 5e-16
 Identities = 116/614 (18%), Positives = 250/614 (40%), Gaps = 71/614 (11%)

Query: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
           L  +  A  E+  WL   +   + Q  +  D+E++ +     +A M +L   +  +  ++
Sbjct: 12  LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430
            A   L  + T + E    I +++  +  +W+ ++    +R+ +L+++L +  +      
Sbjct: 72  TAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ------ 124

Query: 431 SAWLTLTEERIQ-------KMETCPLDD-DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH 482
             WL   EE  Q       K+E+       V ++QK + E K L  DL   Q  V+    
Sbjct: 125 --WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 182

Query: 483 MVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLK 542
           + + +  +     T  +    + +   W ++ +   ER   L+E + L Q+   +     
Sbjct: 183 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 242

Query: 543 AWLTEKEEALNKVQTSNFK-----DQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV 597
           AWLTE E   N +Q +  K     D K +   +++   L+ ++E        L E  Q +
Sbjct: 243 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 598 GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
            + L+ S  +  +    + +  +W  L ++  +  + +  +  +     +  ++LL  ++
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 658 VREQAITKKSKQELPPPPPPKKRQIH--VDIEAKKKFDAISAELLNWILKWKTAIQTTEI 715
           +++  +++++      P   K+  +H     E K K   I + L                
Sbjct: 363 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL---------------- 406

Query: 716 KEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEK 775
            E +++  T +  + L+ L +E RE  P     N                T  ++   E+
Sbjct: 407 -ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQN---------------VTRLLRKQAEE 450

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLP 835
           V++EW+ ++ H  D +RK      I+   ++L EL++     +  ++   + + S Q + 
Sbjct: 451 VNTEWEKLNLHSADWQRK------IDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 504

Query: 836 SLK-DSCQRELTNLLGLHPKIEMARASCSAL--MSQPSAPDFVQRG------FDSFLGRY 886
            L  DS Q  L  +  L  +I   + + S +  +++      +Q         +    R+
Sbjct: 505 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 564

Query: 887 QAVQEAVEDRQQHL 900
           + +Q AVEDR + L
Sbjct: 565 KLLQVAVEDRVRQL 578



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
           +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 218 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 277

Query: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
            +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 278 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 336

Query: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
           +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 337 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 394

Query: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
           L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 395 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 454

Query: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
           W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 455 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 514

Query: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
            E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 515 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 565

Query: 623 SLVQRLEDSSNQVTQAVAKLG 643
            L   +ED   Q+ +A    G
Sbjct: 566 LLQVAVEDRVRQLHEAHRDFG 586



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 114/635 (17%), Positives = 254/635 (40%), Gaps = 79/635 (12%)

Query: 1721 SSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
            SS  L  P LA+ NR + +++  +     +I  +               V   DLE    
Sbjct: 3    SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR--------------VMVGDLE---- 44

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
            DI  M+      ++     + +++   Q+EE++   + + ++      +  I  ++  + 
Sbjct: 45   DINEMI------IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 98

Query: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKIL-LCMDDVELSLNVPELNTAI 1899
             ++++++   +Q R+  QL   ++ S    +   E  ++L      +E     P    AI
Sbjct: 99   NQWDEVQE-HLQNRRQ-QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 156

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDR 1959
             +  +      K +   L +    + V ++    ++ + S  +  ++      +NA W  
Sbjct: 157  QKKIT----ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRS 212

Query: 1960 INRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSLD----LE 2012
            I++  S+R+   +      +QF  DL     W+TEAE    +L D       L+    ++
Sbjct: 213  IHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVK 272

Query: 2013 KARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS-FLKEKLAGLNQRWDAIVAE 2071
            +     Q+L+  I +H   +  L+     I++ L  +D +  L+ +L  +N +W  +  +
Sbjct: 273  ELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332

Query: 2072 VKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEV 2131
              + +  L+  S Q  +    L E++ WL   +  + +++   +G +   ++   ++ +V
Sbjct: 333  SLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA--PIGGDFPAVQ---KQNDV 387

Query: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
            H    + L   E  ++S              +L TV +    +  +    L++  QEP  
Sbjct: 388  HRAFKRELKTKEPVIMS--------------TLETVRIF---LTEQPLEGLEKLYQEPRE 430

Query: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISI--PADLDKTITELADWLVLIDQM- 2248
            +     A   NV + +L   A ++  +  + +  S      +D+T+  L +     D++ 
Sbjct: 431  LPPEERA--QNVTR-LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELD 487

Query: 2249 --------LKSNIVTVGD--VEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                    +K +   VGD  ++ +   + ++K  + ++      + +V  LA+ L     
Sbjct: 488  LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGI 547

Query: 2299 SSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333
                    T  LE +  +W   Q  VE R +QL +
Sbjct: 548  QLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 100/541 (18%), Positives = 198/541 (36%), Gaps = 92/541 (17%)

Query: 1946 IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWIT---EAEELLVDT 2002
            I D + ++  +WD +     +R+          +Q +  L D TQW+    EAE++L   
Sbjct: 90   ITDRIERIQNQWDEVQEHLQNRR----------QQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 2003 CAPGGSLD--------LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             A   S          ++K     ++L   +   Q +    N     +++  S  D   +
Sbjct: 140  RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV 199

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAM 2107
                  +N  W +I   V +R+  L+   + + ++   L++ + WLT+AE        A 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 259

Query: 2108 QKRSTTELGENLQEL----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERD 2158
            +K    E  + ++EL    +DL  E+E H +    L+    ++L     SD ++ L  R 
Sbjct: 260  RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR- 318

Query: 2159 KISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQ 2218
                 L  +N  W+++ ++                                     + ++
Sbjct: 319  -----LDNMNFKWSELRKK------------------------------------SLNIR 337

Query: 2219 SHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQ 2278
            SH  +       L  ++ EL  WL L D  L       GD   + K     +  K +L+ 
Sbjct: 338  SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 397

Query: 2279 RHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS 2338
            + P +       +    +     +     E  E      +  Q+   L ++Q E++   +
Sbjct: 398  KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---N 452

Query: 2339 LQWDDHREETEELMRKYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFD 2395
             +W+     + +  RK +  L  LQ  Q   D L  ++   +++     P GD ++ +  
Sbjct: 453  TEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQ 512

Query: 2396 NVLQKLLEEYG-----SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRR 2450
            + L+K+    G      ++  +V +    L T  I L          L   W+ +Q +  
Sbjct: 513  DHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVE 572

Query: 2451 D 2451
            D
Sbjct: 573  D 573



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 95/519 (18%), Positives = 212/519 (40%), Gaps = 71/519 (13%)

Query: 1637 RTWTE--DWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV 1694
            R WTE  DW + L        +  G++  I+  + + +A + ++E++    +E I     
Sbjct: 17   RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA--- 73

Query: 1695 SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQE 1754
                      +N++++           +R ++  ++  +   +++V +H+++ +     +
Sbjct: 74   ---------AQNLKNKT------SNQEARTIITDRIERIQNQWDEVQEHLQNRR-----Q 113

Query: 1755 PLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVL 1813
             L + L  +  +        LE  E + E +L      LES  E    +D    +I E  
Sbjct: 114  QLNEMLKDSTQW--------LEAKE-EAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 164

Query: 1814 QRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSL 1867
            Q  +++       +    + L+LL  ++  +  K   I +      R + +  S   ++L
Sbjct: 165  QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 224

Query: 1868 LPTDYLVE-----INKILLCMDDVELSLNVPELNTA---IYEDFSFQEDSLKNIKDQLDK 1919
              T  L++     + K L  + + E + NV +  T    + ED    ++ +K  +D   +
Sbjct: 225  EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 284

Query: 1920 LGEQIAVIH---EKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAM 1975
            +     V H   E    ++    G + A+ ++  L  +N KW  + +   + +   + + 
Sbjct: 285  IEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASS 344

Query: 1976 EEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAAL 2035
            ++W++ H  L +L  W+   ++ L      GG          Q++ +V       +F   
Sbjct: 345  DQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRE 394

Query: 2036 NRTGDGIVQKLSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLD 2094
             +T + ++    +    FL E+ L GL    + +  E ++  P  + ++   +  R Q +
Sbjct: 395  LKTKEPVIMSTLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAE 449

Query: 2095 EIIC-WLTKAEHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
            E+   W     H+   +R   E  E LQEL++ T E+++
Sbjct: 450  EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 488



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 106/574 (18%), Positives = 231/574 (40%), Gaps = 67/574 (11%)

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  L+N  
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1616 EGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIFDGNVA 1662
               E   I+ +R+  +   W  V+   ++     N ++    Q         ++     A
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1663 HISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSS 1722
             + +W  +    +D I+KK T       K+L  +L      V+   D AL L+    +  
Sbjct: 142  KLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRDYSADD 195

Query: 1723 RELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
               V      +N ++  + + +  + A L      L Q  +  E F   +  ++ E   N
Sbjct: 196  TRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTAN 253

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ----L 1836
             +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+     
Sbjct: 254  VLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1837 LLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMDDVELS 1889
            +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + D ELS
Sbjct: 313  VLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1890 LNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGP 1941
               P        +    ++  F   +  LK  +  +    E + +   +QP   LE    
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 426

Query: 1942 EAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDL 1988
            E  +             +R    ++N +W+++N   +D +   D  +E  ++     ++L
Sbjct: 427  EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 486

Query: 1989 TQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048
               + +A E++  +  P G L ++  + H ++++       P    ++   D + ++L+ 
Sbjct: 487  DLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LARQLTT 544

Query: 2049 AD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
                   +    L  LN RW  +   V+DR  +L
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 578



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 108/599 (18%), Positives = 232/599 (38%), Gaps = 104/599 (17%)

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL- 1293
            W EL       T WL+ L++ +KS  V+    + +NE +   ++ ++     R Q+ EL 
Sbjct: 19   WTEL-------TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 1294 --GQTLIDGGILDD---IISEKLEAFNSRYEDLSHLAESKQISLEKQL----QVLRETDQ 1344
               Q L +     +   II++++E   ++++++    ++++  L + L    Q L   ++
Sbjct: 72   TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 131

Query: 1345 MLQVLQESLGELDK-QLTTYLTDRI-----DAFQVPQEAQKIQAEIS-AHELTLEELRR- 1396
              QVL ++  +L+  +   Y  D I     +  Q+ ++ ++ Q  +  A++L L+ LR  
Sbjct: 132  AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 1397 --------NMRSQPLT----SPESRTARGGSQMDVLQRKLREVSTKFQLF-------QKP 1437
                    +M ++ +     S   R +   + ++   R L++     + F       +  
Sbjct: 192  SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 251

Query: 1438 ANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIK 1497
            AN  Q     +R+L+  K    ++         I+ H D    +Y  L E   ++     
Sbjct: 252  ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD----VYHNLDENSQKI----- 302

Query: 1498 TGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLS 1557
                +   + +D+   +  +L ++   +++L  +    +  LE +S   +++      L 
Sbjct: 303  ----LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL 358

Query: 1558 EWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLI 1615
             WL   + EL +++   G    +  +    +   ++L+ ++  + +  E+      +  +
Sbjct: 359  VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 418

Query: 1616 EGSEPILEE--------------RLC-----VLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
            EG E + +E              RL       +N  W ++   + DW   +     +L+ 
Sbjct: 419  EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQE 478

Query: 1657 FDGNVAHISTWLYQAE---------------ALLDEIEK--------KPTSKQEEIVKRL 1693
                   +   L QAE               +L D +EK         P  +    V  L
Sbjct: 479  LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDL 538

Query: 1694 VSELDDANLQVENVRDQALILMNARGSSSRELVEPK---LAELNRNFEKVSQHIKSAKL 1749
              +L    +Q+       L  +N R    +  VE +   L E +R+F   SQH  S  +
Sbjct: 539  ARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSV 597



 Score = 35.4 bits (80), Expect = 0.98
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 719  MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
            ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 1038 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 1097

Query: 776  VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
            + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 1098 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 1157

Query: 835  PSLKDSCQRELTNLLG 850
                DS Q  L  ++G
Sbjct: 1158 LQRSDSSQPMLLRVVG 1173


>gi|5032309 dystrophin Dp140b isoform [Homo sapiens]
          Length = 1243

 Score = 1481 bits (3835), Expect = 0.0
 Identities = 730/1205 (60%), Positives = 929/1205 (77%), Gaps = 10/1205 (0%)

Query: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
            E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ + + K T  DLEQR PQL
Sbjct: 8    EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 67

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
            + + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ R+QQL +M+ DS QW +
Sbjct: 68   EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 127

Query: 2344 HREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             +EE E+++ +  A+L   ++     D + K+I++ + L ++L      V   +++  KL
Sbjct: 128  AKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 187

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
            L +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R +Q    DLE FL W+ E
Sbjct: 188  LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 2462 AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALG 2521
            AETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D++ ++D N QK++++L 
Sbjct: 248  AETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 307

Query: 2522 NSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEE 2581
             S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL +SL+EL+ WL +KD+E
Sbjct: 308  GSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 367

Query: 2582 LKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRN 2641
            L +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R+FL +QP+E  E   + 
Sbjct: 368  LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE---KL 424

Query: 2642 LQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD 2701
             Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+++D+ LE+L++LQ A D
Sbjct: 425  YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 484

Query: 2702 DLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
            +LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP+   V  VNDL+ QL+ 
Sbjct: 485  ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 544

Query: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821
            L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 604

Query: 2822 ISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLL 2881
            IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL
Sbjct: 605  ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 664

Query: 2882 ELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLN 2941
             LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLN
Sbjct: 665  SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 724

Query: 2942 VYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQI 3001
            VYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQI
Sbjct: 725  VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 784

Query: 3002 PRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAA 3061
            PRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAA
Sbjct: 785  PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 844

Query: 3062 ETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTT 3121
            ETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTT
Sbjct: 845  ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 904

Query: 3122 SGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQ 3181
            SGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ETP+TLI+ WP    P+ 
Sbjct: 905  SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPAS 964

Query: 3182 SPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESP 3241
            SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP
Sbjct: 965  SPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSP 1024

Query: 3242 VSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPE 3300
            +SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE
Sbjct: 1025 LSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPE 1084

Query: 3301 SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS 3360
             + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++
Sbjct: 1085 MMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEA 1144

Query: 3361 RINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIH 3416
            ++NG    SP  S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++
Sbjct: 1145 KVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLN 1204

Query: 3417 STFPS 3421
            ++FPS
Sbjct: 1205 NSFPS 1209



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 117/589 (19%), Positives = 260/589 (44%), Gaps = 68/589 (11%)

Query: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP 743
            +++ A   F+    EL +W+      I++  +     ++D +EM  K KA  ++  +R P
Sbjct: 7    LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 65

Query: 744  RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINA 802
            + +EL    Q L  +   +   T  I + +E++ ++W  V +HL++  +++ ++ +D   
Sbjct: 66   QLEELITAAQNLKNKTSNQEARTI-ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 124

Query: 803  YFKQLDELEKVIKTK----EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858
            + +  +E E+V+       E W +     ++ ++ +   K   +    +L      +++A
Sbjct: 125  WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK----DLRQWQTNVDVA 180

Query: 859  RASCSALMSQPSAPDF--VQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETL 916
                  L+   SA D   V    ++    ++++ + V +R+  LE            ET 
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE------------ETH 228

Query: 917  KTLKDVLNDSEN------KAQVSLNVLNDLAKVEKALQEKKTLDEIL----------ENQ 960
            + L+    D E       +A+ + NVL D  + E+ L++ K + E++          E  
Sbjct: 229  RLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAH 288

Query: 961  KPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLR 1019
                H L E ++ + +++   D   L ++  D++  KW++L+    K L++   +  +  
Sbjct: 289  TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR---KKSLNIRSHLEASSD 345

Query: 1020 AFEADSTVIEK---WMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES-SLKN 1075
             ++     +++   W+    D L +Q    GD   +Q+Q D   AF  E++T E   +  
Sbjct: 346  QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 405

Query: 1076 MKEIETNLRSGPVAGI-KTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEK----AANL 1130
            ++ +   L   P+ G+ K + + R    + + + +++ +  Q   ++   EK    +A+ 
Sbjct: 406  LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 465

Query: 1131 KKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV-RVKILKDNI 1189
            ++ + E  E + + +E   E D + +  E ++ + + +     D LQ  + +VK L+  I
Sbjct: 466  QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEI 525

Query: 1190 KLL---AAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
              L    + V    ++LT+ L + L  Y L          TLE++ + W
Sbjct: 526  APLKENVSHVNDLARQLTT-LGIQLSPYNL---------STLEDLNTRW 564



 Score = 86.3 bits (212), Expect = 5e-16
 Identities = 116/614 (18%), Positives = 250/614 (40%), Gaps = 71/614 (11%)

Query: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
           L  +  A  E+  WL   +   + Q  +  D+E++ +     +A M +L   +  +  ++
Sbjct: 12  LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430
            A   L  + T + E    I +++  +  +W+ ++    +R+ +L+++L +  +      
Sbjct: 72  TAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ------ 124

Query: 431 SAWLTLTEERIQ-------KMETCPLDD-DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH 482
             WL   EE  Q       K+E+       V ++QK + E K L  DL   Q  V+    
Sbjct: 125 --WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 182

Query: 483 MVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLK 542
           + + +  +     T  +    + +   W ++ +   ER   L+E + L Q+   +     
Sbjct: 183 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 242

Query: 543 AWLTEKEEALNKVQTSNFK-----DQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV 597
           AWLTE E   N +Q +  K     D K +   +++   L+ ++E        L E  Q +
Sbjct: 243 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 598 GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
            + L+ S  +  +    + +  +W  L ++  +  + +  +  +     +  ++LL  ++
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 658 VREQAITKKSKQELPPPPPPKKRQIH--VDIEAKKKFDAISAELLNWILKWKTAIQTTEI 715
           +++  +++++      P   K+  +H     E K K   I + L                
Sbjct: 363 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL---------------- 406

Query: 716 KEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEK 775
            E +++  T +  + L+ L +E RE  P     N                T  ++   E+
Sbjct: 407 -ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQN---------------VTRLLRKQAEE 450

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLP 835
           V++EW+ ++ H  D +RK      I+   ++L EL++     +  ++   + + S Q + 
Sbjct: 451 VNTEWEKLNLHSADWQRK------IDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 504

Query: 836 SLK-DSCQRELTNLLGLHPKIEMARASCSAL--MSQPSAPDFVQRG------FDSFLGRY 886
            L  DS Q  L  +  L  +I   + + S +  +++      +Q         +    R+
Sbjct: 505 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 564

Query: 887 QAVQEAVEDRQQHL 900
           + +Q AVEDR + L
Sbjct: 565 KLLQVAVEDRVRQL 578



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
           +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 218 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 277

Query: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
            +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 278 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 336

Query: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
           +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 337 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 394

Query: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
           L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 395 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 454

Query: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
           W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 455 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 514

Query: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
            E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 515 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 565

Query: 623 SLVQRLEDSSNQVTQAVAKLG 643
            L   +ED   Q+ +A    G
Sbjct: 566 LLQVAVEDRVRQLHEAHRDFG 586



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 114/635 (17%), Positives = 254/635 (40%), Gaps = 79/635 (12%)

Query: 1721 SSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
            SS  L  P LA+ NR + +++  +     +I  +               V   DLE    
Sbjct: 3    SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR--------------VMVGDLE---- 44

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
            DI  M+      ++     + +++   Q+EE++   + + ++      +  I  ++  + 
Sbjct: 45   DINEMI------IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 98

Query: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKIL-LCMDDVELSLNVPELNTAI 1899
             ++++++   +Q R+  QL   ++ S    +   E  ++L      +E     P    AI
Sbjct: 99   NQWDEVQE-HLQNRRQ-QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 156

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDR 1959
             +  +      K +   L +    + V ++    ++ + S  +  ++      +NA W  
Sbjct: 157  QKKIT----ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRS 212

Query: 1960 INRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSLD----LE 2012
            I++  S+R+   +      +QF  DL     W+TEAE    +L D       L+    ++
Sbjct: 213  IHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVK 272

Query: 2013 KARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS-FLKEKLAGLNQRWDAIVAE 2071
            +     Q+L+  I +H   +  L+     I++ L  +D +  L+ +L  +N +W  +  +
Sbjct: 273  ELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332

Query: 2072 VKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEV 2131
              + +  L+  S Q  +    L E++ WL   +  + +++   +G +   ++   ++ +V
Sbjct: 333  SLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA--PIGGDFPAVQ---KQNDV 387

Query: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
            H    + L   E  ++S              +L TV +    +  +    L++  QEP  
Sbjct: 388  HRAFKRELKTKEPVIMS--------------TLETVRIF---LTEQPLEGLEKLYQEPRE 430

Query: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISI--PADLDKTITELADWLVLIDQM- 2248
            +     A   NV + +L   A ++  +  + +  S      +D+T+  L +     D++ 
Sbjct: 431  LPPEERA--QNVTR-LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELD 487

Query: 2249 --------LKSNIVTVGD--VEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                    +K +   VGD  ++ +   + ++K  + ++      + +V  LA+ L     
Sbjct: 488  LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGI 547

Query: 2299 SSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333
                    T  LE +  +W   Q  VE R +QL +
Sbjct: 548  QLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 100/541 (18%), Positives = 198/541 (36%), Gaps = 92/541 (17%)

Query: 1946 IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWIT---EAEELLVDT 2002
            I D + ++  +WD +     +R+          +Q +  L D TQW+    EAE++L   
Sbjct: 90   ITDRIERIQNQWDEVQEHLQNRR----------QQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 2003 CAPGGSLD--------LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             A   S          ++K     ++L   +   Q +    N     +++  S  D   +
Sbjct: 140  RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV 199

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAM 2107
                  +N  W +I   V +R+  L+   + + ++   L++ + WLT+AE        A 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 259

Query: 2108 QKRSTTELGENLQEL----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERD 2158
            +K    E  + ++EL    +DL  E+E H +    L+    ++L     SD ++ L  R 
Sbjct: 260  RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR- 318

Query: 2159 KISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQ 2218
                 L  +N  W+++ ++                                     + ++
Sbjct: 319  -----LDNMNFKWSELRKK------------------------------------SLNIR 337

Query: 2219 SHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQ 2278
            SH  +       L  ++ EL  WL L D  L       GD   + K     +  K +L+ 
Sbjct: 338  SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 397

Query: 2279 RHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS 2338
            + P +       +    +     +     E  E      +  Q+   L ++Q E++   +
Sbjct: 398  KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---N 452

Query: 2339 LQWDDHREETEELMRKYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFD 2395
             +W+     + +  RK +  L  LQ  Q   D L  ++   +++     P GD ++ +  
Sbjct: 453  TEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQ 512

Query: 2396 NVLQKLLEEYG-----SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRR 2450
            + L+K+    G      ++  +V +    L T  I L          L   W+ +Q +  
Sbjct: 513  DHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVE 572

Query: 2451 D 2451
            D
Sbjct: 573  D 573



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 95/519 (18%), Positives = 212/519 (40%), Gaps = 71/519 (13%)

Query: 1637 RTWTE--DWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV 1694
            R WTE  DW + L        +  G++  I+  + + +A + ++E++    +E I     
Sbjct: 17   RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA--- 73

Query: 1695 SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQE 1754
                      +N++++           +R ++  ++  +   +++V +H+++ +     +
Sbjct: 74   ---------AQNLKNKT------SNQEARTIITDRIERIQNQWDEVQEHLQNRR-----Q 113

Query: 1755 PLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVL 1813
             L + L  +  +        LE  E + E +L      LES  E    +D    +I E  
Sbjct: 114  QLNEMLKDSTQW--------LEAKE-EAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 164

Query: 1814 QRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSL 1867
            Q  +++       +    + L+LL  ++  +  K   I +      R + +  S   ++L
Sbjct: 165  QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 224

Query: 1868 LPTDYLVE-----INKILLCMDDVELSLNVPELNTA---IYEDFSFQEDSLKNIKDQLDK 1919
              T  L++     + K L  + + E + NV +  T    + ED    ++ +K  +D   +
Sbjct: 225  EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 284

Query: 1920 LGEQIAVIH---EKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAM 1975
            +     V H   E    ++    G + A+ ++  L  +N KW  + +   + +   + + 
Sbjct: 285  IEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASS 344

Query: 1976 EEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAAL 2035
            ++W++ H  L +L  W+   ++ L      GG          Q++ +V       +F   
Sbjct: 345  DQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRE 394

Query: 2036 NRTGDGIVQKLSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLD 2094
             +T + ++    +    FL E+ L GL    + +  E ++  P  + ++   +  R Q +
Sbjct: 395  LKTKEPVIMSTLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAE 449

Query: 2095 EIIC-WLTKAEHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
            E+   W     H+   +R   E  E LQEL++ T E+++
Sbjct: 450  EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 488



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 106/574 (18%), Positives = 231/574 (40%), Gaps = 67/574 (11%)

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  L+N  
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1616 EGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIFDGNVA 1662
               E   I+ +R+  +   W  V+   ++     N ++    Q         ++     A
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1663 HISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSS 1722
             + +W  +    +D I+KK T       K+L  +L      V+   D AL L+    +  
Sbjct: 142  KLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRDYSADD 195

Query: 1723 RELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
               V      +N ++  + + +  + A L      L Q  +  E F   +  ++ E   N
Sbjct: 196  TRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTAN 253

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ----L 1836
             +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+     
Sbjct: 254  VLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1837 LLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMDDVELS 1889
            +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + D ELS
Sbjct: 313  VLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1890 LNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGP 1941
               P        +    ++  F   +  LK  +  +    E + +   +QP   LE    
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 426

Query: 1942 EAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDL 1988
            E  +             +R    ++N +W+++N   +D +   D  +E  ++     ++L
Sbjct: 427  EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 486

Query: 1989 TQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048
               + +A E++  +  P G L ++  + H ++++       P    ++   D + ++L+ 
Sbjct: 487  DLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LARQLTT 544

Query: 2049 AD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
                   +    L  LN RW  +   V+DR  +L
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 578



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 108/599 (18%), Positives = 232/599 (38%), Gaps = 104/599 (17%)

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL- 1293
            W EL       T WL+ L++ +KS  V+    + +NE +   ++ ++     R Q+ EL 
Sbjct: 19   WTEL-------TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 1294 --GQTLIDGGILDD---IISEKLEAFNSRYEDLSHLAESKQISLEKQL----QVLRETDQ 1344
               Q L +     +   II++++E   ++++++    ++++  L + L    Q L   ++
Sbjct: 72   TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 131

Query: 1345 MLQVLQESLGELDK-QLTTYLTDRI-----DAFQVPQEAQKIQAEIS-AHELTLEELRR- 1396
              QVL ++  +L+  +   Y  D I     +  Q+ ++ ++ Q  +  A++L L+ LR  
Sbjct: 132  AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 1397 --------NMRSQPLT----SPESRTARGGSQMDVLQRKLREVSTKFQLF-------QKP 1437
                    +M ++ +     S   R +   + ++   R L++     + F       +  
Sbjct: 192  SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 251

Query: 1438 ANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIK 1497
            AN  Q     +R+L+  K    ++         I+ H D    +Y  L E   ++     
Sbjct: 252  ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD----VYHNLDENSQKI----- 302

Query: 1498 TGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLS 1557
                +   + +D+   +  +L ++   +++L  +    +  LE +S   +++      L 
Sbjct: 303  ----LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL 358

Query: 1558 EWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLI 1615
             WL   + EL +++   G    +  +    +   ++L+ ++  + +  E+      +  +
Sbjct: 359  VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 418

Query: 1616 EGSEPILEE--------------RLC-----VLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
            EG E + +E              RL       +N  W ++   + DW   +     +L+ 
Sbjct: 419  EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQE 478

Query: 1657 FDGNVAHISTWLYQAE---------------ALLDEIEK--------KPTSKQEEIVKRL 1693
                   +   L QAE               +L D +EK         P  +    V  L
Sbjct: 479  LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDL 538

Query: 1694 VSELDDANLQVENVRDQALILMNARGSSSRELVEPK---LAELNRNFEKVSQHIKSAKL 1749
              +L    +Q+       L  +N R    +  VE +   L E +R+F   SQH  S  +
Sbjct: 539  ARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSV 597



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 42/196 (21%), Positives = 74/196 (37%), Gaps = 24/196 (12%)

Query: 719  MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
            ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 1038 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 1097

Query: 776  VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
            + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 1098 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 1157

Query: 835  PSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVE 894
                DS Q  L  ++G      M                    G +  L   Q     +E
Sbjct: 1158 LQRSDSSQPMLLRVVGSQTSDSM--------------------GEEDLLSPPQDTSTGLE 1197

Query: 895  DRQQHLENELKGQPGH 910
            +  + L N      GH
Sbjct: 1198 EVMEQLNNSFPSSRGH 1213


>gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]
          Length = 1230

 Score = 1459 bits (3776), Expect = 0.0
 Identities = 724/1205 (60%), Positives = 921/1205 (76%), Gaps = 23/1205 (1%)

Query: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
            E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ + + K T  DLEQR PQL
Sbjct: 8    EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 67

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
            + + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ R+QQL +M+ DS QW +
Sbjct: 68   EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 127

Query: 2344 HREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             +EE E+++ +  A+L   ++     D + K+I++ + L ++L      V   +++  KL
Sbjct: 128  AKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 187

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
            L +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R +Q    DLE FL W+ E
Sbjct: 188  LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 2462 AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALG 2521
            AETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D++ ++D N QK++++L 
Sbjct: 248  AETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 307

Query: 2522 NSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEE 2581
             S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL +SL+EL+ WL +KD+E
Sbjct: 308  GSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 367

Query: 2582 LKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRN 2641
            L +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R+FL +QP+E  E   + 
Sbjct: 368  LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE---KL 424

Query: 2642 LQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD 2701
             Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+++D+ LE+L++LQ A D
Sbjct: 425  YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 484

Query: 2702 DLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
            +LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP+   V  VNDL+ QL+ 
Sbjct: 485  ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 544

Query: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821
            L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 604

Query: 2822 ISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLL 2881
            IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL
Sbjct: 605  ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 664

Query: 2882 ELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLN 2941
             LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLN
Sbjct: 665  SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 724

Query: 2942 VYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQI 3001
            VYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQI
Sbjct: 725  VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 784

Query: 3002 PRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAA 3061
            PRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAA
Sbjct: 785  PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 844

Query: 3062 ETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTT 3121
            ETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTT
Sbjct: 845  ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 904

Query: 3122 SGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQ 3181
            SGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ET             P+ 
Sbjct: 905  SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PAS 951

Query: 3182 SPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESP 3241
            SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP
Sbjct: 952  SPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSP 1011

Query: 3242 VSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPE 3300
            +SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE
Sbjct: 1012 LSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPE 1071

Query: 3301 SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS 3360
             + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++
Sbjct: 1072 MMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEA 1131

Query: 3361 RINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIH 3416
            ++NG    SP  S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++
Sbjct: 1132 KVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLN 1191

Query: 3417 STFPS 3421
            ++FPS
Sbjct: 1192 NSFPS 1196



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 117/589 (19%), Positives = 260/589 (44%), Gaps = 68/589 (11%)

Query: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP 743
            +++ A   F+    EL +W+      I++  +     ++D +EM  K KA  ++  +R P
Sbjct: 7    LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 65

Query: 744  RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINA 802
            + +EL    Q L  +   +   T  I + +E++ ++W  V +HL++  +++ ++ +D   
Sbjct: 66   QLEELITAAQNLKNKTSNQEARTI-ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 124

Query: 803  YFKQLDELEKVIKTK----EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858
            + +  +E E+V+       E W +     ++ ++ +   K   +    +L      +++A
Sbjct: 125  WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK----DLRQWQTNVDVA 180

Query: 859  RASCSALMSQPSAPDF--VQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETL 916
                  L+   SA D   V    ++    ++++ + V +R+  LE            ET 
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE------------ETH 228

Query: 917  KTLKDVLNDSEN------KAQVSLNVLNDLAKVEKALQEKKTLDEIL----------ENQ 960
            + L+    D E       +A+ + NVL D  + E+ L++ K + E++          E  
Sbjct: 229  RLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAH 288

Query: 961  KPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLR 1019
                H L E ++ + +++   D   L ++  D++  KW++L+    K L++   +  +  
Sbjct: 289  TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR---KKSLNIRSHLEASSD 345

Query: 1020 AFEADSTVIEK---WMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES-SLKN 1075
             ++     +++   W+    D L +Q    GD   +Q+Q D   AF  E++T E   +  
Sbjct: 346  QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 405

Query: 1076 MKEIETNLRSGPVAGI-KTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEK----AANL 1130
            ++ +   L   P+ G+ K + + R    + + + +++ +  Q   ++   EK    +A+ 
Sbjct: 406  LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 465

Query: 1131 KKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV-RVKILKDNI 1189
            ++ + E  E + + +E   E D + +  E ++ + + +     D LQ  + +VK L+  I
Sbjct: 466  QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEI 525

Query: 1190 KLL---AAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
              L    + V    ++LT+ L + L  Y L          TLE++ + W
Sbjct: 526  APLKENVSHVNDLARQLTT-LGIQLSPYNL---------STLEDLNTRW 564



 Score = 86.3 bits (212), Expect = 5e-16
 Identities = 116/614 (18%), Positives = 250/614 (40%), Gaps = 71/614 (11%)

Query: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
           L  +  A  E+  WL   +   + Q  +  D+E++ +     +A M +L   +  +  ++
Sbjct: 12  LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430
            A   L  + T + E    I +++  +  +W+ ++    +R+ +L+++L +  +      
Sbjct: 72  TAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ------ 124

Query: 431 SAWLTLTEERIQ-------KMETCPLDD-DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH 482
             WL   EE  Q       K+E+       V ++QK + E K L  DL   Q  V+    
Sbjct: 125 --WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 182

Query: 483 MVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLK 542
           + + +  +     T  +    + +   W ++ +   ER   L+E + L Q+   +     
Sbjct: 183 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 242

Query: 543 AWLTEKEEALNKVQTSNFK-----DQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV 597
           AWLTE E   N +Q +  K     D K +   +++   L+ ++E        L E  Q +
Sbjct: 243 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 598 GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
            + L+ S  +  +    + +  +W  L ++  +  + +  +  +     +  ++LL  ++
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 658 VREQAITKKSKQELPPPPPPKKRQIH--VDIEAKKKFDAISAELLNWILKWKTAIQTTEI 715
           +++  +++++      P   K+  +H     E K K   I + L                
Sbjct: 363 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL---------------- 406

Query: 716 KEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEK 775
            E +++  T +  + L+ L +E RE  P     N                T  ++   E+
Sbjct: 407 -ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQN---------------VTRLLRKQAEE 450

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLP 835
           V++EW+ ++ H  D +RK      I+   ++L EL++     +  ++   + + S Q + 
Sbjct: 451 VNTEWEKLNLHSADWQRK------IDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 504

Query: 836 SLK-DSCQRELTNLLGLHPKIEMARASCSAL--MSQPSAPDFVQRG------FDSFLGRY 886
            L  DS Q  L  +  L  +I   + + S +  +++      +Q         +    R+
Sbjct: 505 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 564

Query: 887 QAVQEAVEDRQQHL 900
           + +Q AVEDR + L
Sbjct: 565 KLLQVAVEDRVRQL 578



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
           +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 218 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 277

Query: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
            +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 278 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 336

Query: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
           +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 337 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 394

Query: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
           L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 395 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 454

Query: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
           W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 455 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 514

Query: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
            E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 515 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 565

Query: 623 SLVQRLEDSSNQVTQAVAKLG 643
            L   +ED   Q+ +A    G
Sbjct: 566 LLQVAVEDRVRQLHEAHRDFG 586



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 114/635 (17%), Positives = 254/635 (40%), Gaps = 79/635 (12%)

Query: 1721 SSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
            SS  L  P LA+ NR + +++  +     +I  +               V   DLE    
Sbjct: 3    SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR--------------VMVGDLE---- 44

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
            DI  M+      ++     + +++   Q+EE++   + + ++      +  I  ++  + 
Sbjct: 45   DINEMI------IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 98

Query: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKIL-LCMDDVELSLNVPELNTAI 1899
             ++++++   +Q R+  QL   ++ S    +   E  ++L      +E     P    AI
Sbjct: 99   NQWDEVQE-HLQNRRQ-QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 156

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDR 1959
             +  +      K +   L +    + V ++    ++ + S  +  ++      +NA W  
Sbjct: 157  QKKIT----ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRS 212

Query: 1960 INRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSLD----LE 2012
            I++  S+R+   +      +QF  DL     W+TEAE    +L D       L+    ++
Sbjct: 213  IHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVK 272

Query: 2013 KARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS-FLKEKLAGLNQRWDAIVAE 2071
            +     Q+L+  I +H   +  L+     I++ L  +D +  L+ +L  +N +W  +  +
Sbjct: 273  ELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332

Query: 2072 VKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEV 2131
              + +  L+  S Q  +    L E++ WL   +  + +++   +G +   ++   ++ +V
Sbjct: 333  SLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA--PIGGDFPAVQ---KQNDV 387

Query: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
            H    + L   E  ++S              +L TV +    +  +    L++  QEP  
Sbjct: 388  HRAFKRELKTKEPVIMS--------------TLETVRIF---LTEQPLEGLEKLYQEPRE 430

Query: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISI--PADLDKTITELADWLVLIDQM- 2248
            +     A   NV + +L   A ++  +  + +  S      +D+T+  L +     D++ 
Sbjct: 431  LPPEERA--QNVTR-LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELD 487

Query: 2249 --------LKSNIVTVGD--VEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                    +K +   VGD  ++ +   + ++K  + ++      + +V  LA+ L     
Sbjct: 488  LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGI 547

Query: 2299 SSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333
                    T  LE +  +W   Q  VE R +QL +
Sbjct: 548  QLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 100/541 (18%), Positives = 198/541 (36%), Gaps = 92/541 (17%)

Query: 1946 IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWIT---EAEELLVDT 2002
            I D + ++  +WD +     +R+          +Q +  L D TQW+    EAE++L   
Sbjct: 90   ITDRIERIQNQWDEVQEHLQNRR----------QQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 2003 CAPGGSLD--------LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             A   S          ++K     ++L   +   Q +    N     +++  S  D   +
Sbjct: 140  RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV 199

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAM 2107
                  +N  W +I   V +R+  L+   + + ++   L++ + WLT+AE        A 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 259

Query: 2108 QKRSTTELGENLQEL----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERD 2158
            +K    E  + ++EL    +DL  E+E H +    L+    ++L     SD ++ L  R 
Sbjct: 260  RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR- 318

Query: 2159 KISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQ 2218
                 L  +N  W+++ ++                                     + ++
Sbjct: 319  -----LDNMNFKWSELRKK------------------------------------SLNIR 337

Query: 2219 SHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQ 2278
            SH  +       L  ++ EL  WL L D  L       GD   + K     +  K +L+ 
Sbjct: 338  SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 397

Query: 2279 RHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS 2338
            + P +       +    +     +     E  E      +  Q+   L ++Q E++   +
Sbjct: 398  KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---N 452

Query: 2339 LQWDDHREETEELMRKYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFD 2395
             +W+     + +  RK +  L  LQ  Q   D L  ++   +++     P GD ++ +  
Sbjct: 453  TEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQ 512

Query: 2396 NVLQKLLEEYG-----SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRR 2450
            + L+K+    G      ++  +V +    L T  I L          L   W+ +Q +  
Sbjct: 513  DHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVE 572

Query: 2451 D 2451
            D
Sbjct: 573  D 573



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 95/519 (18%), Positives = 212/519 (40%), Gaps = 71/519 (13%)

Query: 1637 RTWTE--DWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV 1694
            R WTE  DW + L        +  G++  I+  + + +A + ++E++    +E I     
Sbjct: 17   RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA--- 73

Query: 1695 SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQE 1754
                      +N++++           +R ++  ++  +   +++V +H+++ +     +
Sbjct: 74   ---------AQNLKNKT------SNQEARTIITDRIERIQNQWDEVQEHLQNRR-----Q 113

Query: 1755 PLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVL 1813
             L + L  +  +        LE  E + E +L      LES  E    +D    +I E  
Sbjct: 114  QLNEMLKDSTQW--------LEAKE-EAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 164

Query: 1814 QRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSL 1867
            Q  +++       +    + L+LL  ++  +  K   I +      R + +  S   ++L
Sbjct: 165  QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 224

Query: 1868 LPTDYLVE-----INKILLCMDDVELSLNVPELNTA---IYEDFSFQEDSLKNIKDQLDK 1919
              T  L++     + K L  + + E + NV +  T    + ED    ++ +K  +D   +
Sbjct: 225  EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 284

Query: 1920 LGEQIAVIH---EKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAM 1975
            +     V H   E    ++    G + A+ ++  L  +N KW  + +   + +   + + 
Sbjct: 285  IEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASS 344

Query: 1976 EEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAAL 2035
            ++W++ H  L +L  W+   ++ L      GG          Q++ +V       +F   
Sbjct: 345  DQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRE 394

Query: 2036 NRTGDGIVQKLSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLD 2094
             +T + ++    +    FL E+ L GL    + +  E ++  P  + ++   +  R Q +
Sbjct: 395  LKTKEPVIMSTLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAE 449

Query: 2095 EIIC-WLTKAEHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
            E+   W     H+   +R   E  E LQEL++ T E+++
Sbjct: 450  EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 488



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 106/574 (18%), Positives = 231/574 (40%), Gaps = 67/574 (11%)

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  L+N  
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1616 EGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIFDGNVA 1662
               E   I+ +R+  +   W  V+   ++     N ++    Q         ++     A
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1663 HISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSS 1722
             + +W  +    +D I+KK T       K+L  +L      V+   D AL L+    +  
Sbjct: 142  KLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRDYSADD 195

Query: 1723 RELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
               V      +N ++  + + +  + A L      L Q  +  E F   +  ++ E   N
Sbjct: 196  TRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTAN 253

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ----L 1836
             +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+     
Sbjct: 254  VLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1837 LLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMDDVELS 1889
            +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + D ELS
Sbjct: 313  VLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1890 LNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGP 1941
               P        +    ++  F   +  LK  +  +    E + +   +QP   LE    
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 426

Query: 1942 EAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDL 1988
            E  +             +R    ++N +W+++N   +D +   D  +E  ++     ++L
Sbjct: 427  EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 486

Query: 1989 TQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048
               + +A E++  +  P G L ++  + H ++++       P    ++   D + ++L+ 
Sbjct: 487  DLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LARQLTT 544

Query: 2049 AD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
                   +    L  LN RW  +   V+DR  +L
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 578



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 108/599 (18%), Positives = 232/599 (38%), Gaps = 104/599 (17%)

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL- 1293
            W EL       T WL+ L++ +KS  V+    + +NE +   ++ ++     R Q+ EL 
Sbjct: 19   WTEL-------TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 1294 --GQTLIDGGILDD---IISEKLEAFNSRYEDLSHLAESKQISLEKQL----QVLRETDQ 1344
               Q L +     +   II++++E   ++++++    ++++  L + L    Q L   ++
Sbjct: 72   TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 131

Query: 1345 MLQVLQESLGELDK-QLTTYLTDRI-----DAFQVPQEAQKIQAEIS-AHELTLEELRR- 1396
              QVL ++  +L+  +   Y  D I     +  Q+ ++ ++ Q  +  A++L L+ LR  
Sbjct: 132  AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 1397 --------NMRSQPLT----SPESRTARGGSQMDVLQRKLREVSTKFQLF-------QKP 1437
                    +M ++ +     S   R +   + ++   R L++     + F       +  
Sbjct: 192  SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 251

Query: 1438 ANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIK 1497
            AN  Q     +R+L+  K    ++         I+ H D    +Y  L E   ++     
Sbjct: 252  ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD----VYHNLDENSQKI----- 302

Query: 1498 TGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLS 1557
                +   + +D+   +  +L ++   +++L  +    +  LE +S   +++      L 
Sbjct: 303  ----LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL 358

Query: 1558 EWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLI 1615
             WL   + EL +++   G    +  +    +   ++L+ ++  + +  E+      +  +
Sbjct: 359  VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 418

Query: 1616 EGSEPILEE--------------RLC-----VLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
            EG E + +E              RL       +N  W ++   + DW   +     +L+ 
Sbjct: 419  EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQE 478

Query: 1657 FDGNVAHISTWLYQAE---------------ALLDEIEK--------KPTSKQEEIVKRL 1693
                   +   L QAE               +L D +EK         P  +    V  L
Sbjct: 479  LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDL 538

Query: 1694 VSELDDANLQVENVRDQALILMNARGSSSRELVEPK---LAELNRNFEKVSQHIKSAKL 1749
              +L    +Q+       L  +N R    +  VE +   L E +R+F   SQH  S  +
Sbjct: 539  ARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSV 597



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 42/196 (21%), Positives = 74/196 (37%), Gaps = 24/196 (12%)

Query: 719  MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
            ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 1025 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 1084

Query: 776  VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
            + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 1085 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 1144

Query: 835  PSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVE 894
                DS Q  L  ++G      M                    G +  L   Q     +E
Sbjct: 1145 LQRSDSSQPMLLRVVGSQTSDSM--------------------GEEDLLSPPQDTSTGLE 1184

Query: 895  DRQQHLENELKGQPGH 910
            +  + L N      GH
Sbjct: 1185 EVMEQLNNSFPSSRGH 1200


>gi|5032295 dystrophin Dp116 isoform [Homo sapiens]
          Length = 956

 Score = 1270 bits (3286), Expect = 0.0
 Identities = 619/945 (65%), Positives = 760/945 (80%), Gaps = 9/945 (0%)

Query: 2492 MQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIR 2551
            ++D+Q EI+AH D++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR
Sbjct: 9    VKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 68

Query: 2552 AHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE 2611
            +HLEAS+++W RL +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK 
Sbjct: 69   SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 128

Query: 2612 KEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEK 2671
            KE  +++ ++  R+FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +
Sbjct: 129  KEPVIMSTLETVRIFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 185

Query: 2672 WESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDH 2731
            WE LN  +++WQ+++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH
Sbjct: 186  WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 245

Query: 2732 IEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDR 2791
            +EK+ A R EIAP+   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR
Sbjct: 246  LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 305

Query: 2792 LKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQS 2851
            ++QL EAHRDFGP+SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QS
Sbjct: 306  VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 365

Query: 2852 LADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCL 2911
            LADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCL
Sbjct: 366  LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 425

Query: 2912 TTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEK 2971
            TT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+K
Sbjct: 426  TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 485

Query: 2972 YRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKP 3031
            YRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKP
Sbjct: 486  YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 545

Query: 3032 EISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNY 3091
            EI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNY
Sbjct: 546  EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 605

Query: 3092 DVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGY 3151
            D+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GY
Sbjct: 606  DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 665

Query: 3152 LPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSF 3211
            LPVQTVLEGDN+ETP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+
Sbjct: 666  LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 725

Query: 3212 LTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLE 3271
            L DS S   S++DEH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLE
Sbjct: 726  LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 785

Query: 3272 EEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEA 3330
            EE RNLQ EY++LK QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEA
Sbjct: 786  EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 845

Query: 3331 RMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGP 3387
            RMQILEDHNKQLESQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G 
Sbjct: 846  RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 905

Query: 3388 QFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
            Q   + G EDLL+PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 906  QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 950



 Score = 62.4 bits (150), Expect = 7e-09
 Identities = 59/233 (25%), Positives = 95/233 (40%), Gaps = 26/233 (11%)

Query: 316 IALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQ 375
           ++L+E+L WL   +D    Q  I  D   V+ Q   H AF  EL   +  + S L+    
Sbjct: 83  LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 142

Query: 376 LITQGTLSDEEEFE------------------IQEQMTLLNARWEALRVESMDRQSRLHD 417
            +T+  L   E+                    +++Q   +N  WE L + S D Q ++ +
Sbjct: 143 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 202

Query: 418 VLMELQKKQLQQLSAWLTLTEERIQKMETCPLDD-DVKSLQKLLEEHKSLQSD---LEAE 473
            L  LQ+ Q       L L +  + K    P+ D  + SLQ  LE+ K+L+ +   L+  
Sbjct: 203 TLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKEN 262

Query: 474 QVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQE 526
              VN L   +  +         + LED    L  RW  +    E+R  +L E
Sbjct: 263 VSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVRQLHE 311



 Score = 55.5 bits (132), Expect = 9e-07
 Identities = 65/315 (20%), Positives = 129/315 (40%), Gaps = 41/315 (13%)

Query: 358 ELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHD 417
           E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ +S L  
Sbjct: 15  EIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 73

Query: 418 VLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQV 475
              + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +L+ ++ 
Sbjct: 74  SSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRELKTKEP 131

Query: 476 KVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGERWTAVCR 515
            + S    V I                      E   ++ T +L  Q +++   W  +  
Sbjct: 132 VIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNL 191

Query: 516 WTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQKELSVS 569
            + +   ++ E     QEL E    L   L + E      + +  +   + +D  E   +
Sbjct: 192 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 251

Query: 570 VR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRL 628
           +R  +A LKE++        QL+ +G  +         S    S  E+L  RW  L   +
Sbjct: 252 LRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWKLLQVAV 302

Query: 629 EDSSNQVTQAVAKLG 643
           ED   Q+ +A    G
Sbjct: 303 EDRVRQLHEAHRDFG 317



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 62/299 (20%), Positives = 134/299 (44%), Gaps = 27/299 (9%)

Query: 951  KTLDEILENQKPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLH 1009
            K L   +E      H L E ++ + +++   D   L ++  D++  KW++L+    K L+
Sbjct: 10   KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR---KKSLN 66

Query: 1010 LLEEIALTLRAFEADSTVIEK---WMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEI 1066
            +   +  +   ++     +++   W+    D L +Q    GD   +Q+Q D   AF  E+
Sbjct: 67   IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 126

Query: 1067 ETIES-SLKNMKEIETNLRSGPVAGI-KTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQ 1124
            +T E   +  ++ +   L   P+ G+ K + + R    + + + +++ +  Q   ++   
Sbjct: 127  KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 186

Query: 1125 EK----AANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV 1180
            EK    +A+ ++ + E  E + + +E   E D + +  E ++ + + +     D LQ  +
Sbjct: 187  EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHL 246

Query: 1181 -RVKILKDNIKLL---AAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
             +VK L+  I  L    + V    ++LT+ L + L  Y L          TLE++ + W
Sbjct: 247  EKVKALRGEIAPLKENVSHVNDLARQLTT-LGIQLSPYNL---------STLEDLNTRW 295



 Score = 42.0 bits (97), Expect = 0.010
 Identities = 56/250 (22%), Positives = 109/250 (43%), Gaps = 25/250 (10%)

Query: 2395 DNVLQKLLEEY-GSDDTRNVKETTEYLKTSWINLKQSIADRQNALEA---EWRTVQASRR 2450
            D   QK+L    GSDD   ++   + +   W  L++   + ++ LEA   +W+ +  S  
Sbjct: 27   DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLS-- 84

Query: 2451 DLENFLKWIQ------EAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
             L+  L W+Q        +  +     A  ++N +  +   RELK +   I + ++    
Sbjct: 85   -LQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA-FKRELKTKEPVIMSTLETVR- 141

Query: 2505 IF---KSIDGNRQ--KMVKALGNSEEA----TMLQHRLDDMNQRWNDLKAKSASIRAHLE 2555
            IF   + ++G  +  +  + L   E A     +L+ + +++N  W  L   SA  +  ++
Sbjct: 142  IFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKID 201

Query: 2556 ASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGG-DVPALQLQYDHCKALRRELKEKEY 2614
             + E+   L  + +EL   L   +       P+G   + +LQ   +  KALR E+   + 
Sbjct: 202  ETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKE 261

Query: 2615 SVLNAVDQAR 2624
            +V +  D AR
Sbjct: 262  NVSHVNDLAR 271



 Score = 40.8 bits (94), Expect = 0.023
 Identities = 45/227 (19%), Positives = 97/227 (42%), Gaps = 22/227 (9%)

Query: 1912 NIKDQLDKLGEQIAVIH---EKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDR 1967
            ++KD   ++     V H   E    ++    G + A+ ++  L  +N KW  + +   + 
Sbjct: 8    HVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 67

Query: 1968 KGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISS 2027
            +   + + ++W++ H  L +L  W+   ++ L      GG          Q++ +V    
Sbjct: 68   RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV---- 118

Query: 2028 HQPSFAALNRTGDGIVQKLSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQV 2086
               +F    +T + ++    +    FL E+ L GL    + +  E ++  P  + ++   
Sbjct: 119  -HRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTR 173

Query: 2087 MKYRHQLDEIIC-WLTKAEHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
            +  R Q +E+   W     H+   +R   E  E LQEL++ T E+++
Sbjct: 174  L-LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 219



 Score = 37.4 bits (85), Expect = 0.26
 Identities = 45/235 (19%), Positives = 95/235 (40%), Gaps = 29/235 (12%)

Query: 453 VKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTA 512
           VK LQ  +E H  +  +L+    K         I+    G     +L+ +L  +  +W+ 
Sbjct: 9   VKDLQGEIEAHTDVYHNLDENSQK---------ILRSLEGSDDAVLLQRRLDNMNFKWSE 59

Query: 513 VCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNK----------VQTSN--- 559
           + + +    + L+  +  W+ L      L  WL  K++ L++          VQ  N   
Sbjct: 60  LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 119

Query: 560 --FKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKA---SKKINSDS 614
             FK + +    V    +    + +  Q L+ L ++ Q+  +L    +A   ++ +   +
Sbjct: 120 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 179

Query: 615 EELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQ 669
           EE+   W+ L     D   ++ + + +L   Q    +L   +++R+  + K S Q
Sbjct: 180 EEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL--DLKLRQAEVIKGSWQ 232



 Score = 35.4 bits (80), Expect = 0.98
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 719 MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
           ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 769 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 828

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
           + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 829 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 888

Query: 835 PSLKDSCQRELTNLLG 850
               DS Q  L  ++G
Sbjct: 889 LQRSDSSQPMLLRVVG 904



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 58/334 (17%), Positives = 137/334 (41%), Gaps = 45/334 (13%)

Query: 576 LKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQV 635
           L+ ++E        L E  Q + + L+ S  +  +    + +  +W  L ++  +  + +
Sbjct: 12  LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 71

Query: 636 TQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAI 695
             +  +     +  ++LL  +++++  +++++      P   K+  +H   + +      
Sbjct: 72  EASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE------ 125

Query: 696 SAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQIL 755
                   LK K  +  + + E +++  T +  + L+ L +E RE  P     N T    
Sbjct: 126 --------LKTKEPVIMSTL-ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT---- 172

Query: 756 VEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIK 815
                        ++   E+V++EW+ ++ H  D +RK      I+   ++L EL++   
Sbjct: 173 -----------RLLRKQAEEVNTEWEKLNLHSADWQRK------IDETLERLQELQEATD 215

Query: 816 TKEEWVKHTSISESSRQSLPSLK-DSCQRELTNLLGLHPKIEMARASCSAL--MSQPSAP 872
             +  ++   + + S Q +  L  DS Q  L  +  L  +I   + + S +  +++    
Sbjct: 216 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 275

Query: 873 DFVQRG------FDSFLGRYQAVQEAVEDRQQHL 900
             +Q         +    R++ +Q AVEDR + L
Sbjct: 276 LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 309



 Score = 34.3 bits (77), Expect = 2.2
 Identities = 46/243 (18%), Positives = 90/243 (37%), Gaps = 13/243 (5%)

Query: 2217 VQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADL 2276
            ++SH  +       L  ++ EL  WL L D  L       GD   + K     +  K +L
Sbjct: 67   IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 126

Query: 2277 EQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMII 2336
            + + P +       +    +     +     E  E      +  Q+   L ++Q E++  
Sbjct: 127  KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV-- 182

Query: 2337 DSLQWDDHREETEELMRKYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMA 2393
             + +W+     + +  RK +  L  LQ  Q   D L  ++   +++     P GD ++ +
Sbjct: 183  -NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 241

Query: 2394 FDNVLQKLLEEYG-----SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQAS 2448
              + L+K+    G      ++  +V +    L T  I L          L   W+ +Q +
Sbjct: 242  LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA 301

Query: 2449 RRD 2451
              D
Sbjct: 302  VED 304


>gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]
          Length = 1133

 Score = 1170 bits (3027), Expect = 0.0
 Identities = 565/944 (59%), Positives = 728/944 (77%), Gaps = 5/944 (0%)

Query: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
            E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ + + K T  DLEQR PQL
Sbjct: 8    EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 67

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
            + + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ R+QQL +M+ DS QW +
Sbjct: 68   EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 127

Query: 2344 HREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             +EE E+++ +  A+L   ++     D + K+I++ + L ++L      V   +++  KL
Sbjct: 128  AKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 187

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
            L +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R +Q    DLE FL W+ E
Sbjct: 188  LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 2462 AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALG 2521
            AETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D++ ++D N QK++++L 
Sbjct: 248  AETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 307

Query: 2522 NSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEE 2581
             S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL +SL+EL+ WL +KD+E
Sbjct: 308  GSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 367

Query: 2582 LKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRN 2641
            L +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R+FL +QP+E  E   + 
Sbjct: 368  LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE---KL 424

Query: 2642 LQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD 2701
             Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+++D+ LE+L++LQ A D
Sbjct: 425  YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 484

Query: 2702 DLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
            +LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP+   V  VNDL+ QL+ 
Sbjct: 485  ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 544

Query: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821
            L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 604

Query: 2822 ISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLL 2881
            IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL
Sbjct: 605  ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 664

Query: 2882 ELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLN 2941
             LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLN
Sbjct: 665  SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 724

Query: 2942 VYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQI 3001
            VYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQI
Sbjct: 725  VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 784

Query: 3002 PRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAA 3061
            PRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAA
Sbjct: 785  PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 844

Query: 3062 ETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTT 3121
            ETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTT
Sbjct: 845  ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 904

Query: 3122 SGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLET 3165
            SGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ET
Sbjct: 905  SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 948



 Score =  166 bits (419), Expect = 5e-40
 Identities = 104/211 (49%), Positives = 137/211 (64%), Gaps = 19/211 (9%)

Query: 3226 HALIQQYCQ-TLGGESPVSQPQSPAQILKSVEREER--------GELE-RIIADLEEEQR 3275
            H  + +YC  T  GE      +  A++LK+  R +R        G L  + + + +  + 
Sbjct: 893  HYPMVEYCTPTTSGEDV----RDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 948

Query: 3276 NLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQI 3334
            NLQ EY++LK QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQI
Sbjct: 949  NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 1008

Query: 3335 LEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQ 3391
            LEDHNKQLESQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   
Sbjct: 1009 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 1068

Query: 3392 AAG-EDLLAPPHDTSTDLTEVMEQIHSTFPS 3421
            + G EDLL+PP DTST L EVMEQ++++FPS
Sbjct: 1069 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS 1099



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 117/589 (19%), Positives = 260/589 (44%), Gaps = 68/589 (11%)

Query: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP 743
            +++ A   F+    EL +W+      I++  +     ++D +EM  K KA  ++  +R P
Sbjct: 7    LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 65

Query: 744  RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINA 802
            + +EL    Q L  +   +   T  I + +E++ ++W  V +HL++  +++ ++ +D   
Sbjct: 66   QLEELITAAQNLKNKTSNQEARTI-ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 124

Query: 803  YFKQLDELEKVIKTK----EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858
            + +  +E E+V+       E W +     ++ ++ +   K   +    +L      +++A
Sbjct: 125  WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK----DLRQWQTNVDVA 180

Query: 859  RASCSALMSQPSAPDF--VQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETL 916
                  L+   SA D   V    ++    ++++ + V +R+  LE            ET 
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE------------ETH 228

Query: 917  KTLKDVLNDSEN------KAQVSLNVLNDLAKVEKALQEKKTLDEIL----------ENQ 960
            + L+    D E       +A+ + NVL D  + E+ L++ K + E++          E  
Sbjct: 229  RLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAH 288

Query: 961  KPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLR 1019
                H L E ++ + +++   D   L ++  D++  KW++L+    K L++   +  +  
Sbjct: 289  TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR---KKSLNIRSHLEASSD 345

Query: 1020 AFEADSTVIEK---WMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES-SLKN 1075
             ++     +++   W+    D L +Q    GD   +Q+Q D   AF  E++T E   +  
Sbjct: 346  QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 405

Query: 1076 MKEIETNLRSGPVAGI-KTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEK----AANL 1130
            ++ +   L   P+ G+ K + + R    + + + +++ +  Q   ++   EK    +A+ 
Sbjct: 406  LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 465

Query: 1131 KKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV-RVKILKDNI 1189
            ++ + E  E + + +E   E D + +  E ++ + + +     D LQ  + +VK L+  I
Sbjct: 466  QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEI 525

Query: 1190 KLL---AAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
              L    + V    ++LT+ L + L  Y L          TLE++ + W
Sbjct: 526  APLKENVSHVNDLARQLTT-LGIQLSPYNL---------STLEDLNTRW 564



 Score = 86.3 bits (212), Expect = 5e-16
 Identities = 116/614 (18%), Positives = 250/614 (40%), Gaps = 71/614 (11%)

Query: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
           L  +  A  E+  WL   +   + Q  +  D+E++ +     +A M +L   +  +  ++
Sbjct: 12  LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430
            A   L  + T + E    I +++  +  +W+ ++    +R+ +L+++L +  +      
Sbjct: 72  TAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ------ 124

Query: 431 SAWLTLTEERIQ-------KMETCPLDD-DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH 482
             WL   EE  Q       K+E+       V ++QK + E K L  DL   Q  V+    
Sbjct: 125 --WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 182

Query: 483 MVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLK 542
           + + +  +     T  +    + +   W ++ +   ER   L+E + L Q+   +     
Sbjct: 183 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 242

Query: 543 AWLTEKEEALNKVQTSNFK-----DQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV 597
           AWLTE E   N +Q +  K     D K +   +++   L+ ++E        L E  Q +
Sbjct: 243 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 598 GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
            + L+ S  +  +    + +  +W  L ++  +  + +  +  +     +  ++LL  ++
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 658 VREQAITKKSKQELPPPPPPKKRQIH--VDIEAKKKFDAISAELLNWILKWKTAIQTTEI 715
           +++  +++++      P   K+  +H     E K K   I + L                
Sbjct: 363 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL---------------- 406

Query: 716 KEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEK 775
            E +++  T +  + L+ L +E RE  P     N                T  ++   E+
Sbjct: 407 -ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQN---------------VTRLLRKQAEE 450

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLP 835
           V++EW+ ++ H  D +RK      I+   ++L EL++     +  ++   + + S Q + 
Sbjct: 451 VNTEWEKLNLHSADWQRK------IDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 504

Query: 836 SLK-DSCQRELTNLLGLHPKIEMARASCSAL--MSQPSAPDFVQRG------FDSFLGRY 886
            L  DS Q  L  +  L  +I   + + S +  +++      +Q         +    R+
Sbjct: 505 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 564

Query: 887 QAVQEAVEDRQQHL 900
           + +Q AVEDR + L
Sbjct: 565 KLLQVAVEDRVRQL 578



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
           +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 218 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 277

Query: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
            +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 278 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 336

Query: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
           +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 337 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 394

Query: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
           L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 395 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 454

Query: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
           W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 455 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 514

Query: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
            E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 515 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 565

Query: 623 SLVQRLEDSSNQVTQAVAKLG 643
            L   +ED   Q+ +A    G
Sbjct: 566 LLQVAVEDRVRQLHEAHRDFG 586



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 114/635 (17%), Positives = 254/635 (40%), Gaps = 79/635 (12%)

Query: 1721 SSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
            SS  L  P LA+ NR + +++  +     +I  +               V   DLE    
Sbjct: 3    SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR--------------VMVGDLE---- 44

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
            DI  M+      ++     + +++   Q+EE++   + + ++      +  I  ++  + 
Sbjct: 45   DINEMI------IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 98

Query: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKIL-LCMDDVELSLNVPELNTAI 1899
             ++++++   +Q R+  QL   ++ S    +   E  ++L      +E     P    AI
Sbjct: 99   NQWDEVQE-HLQNRRQ-QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 156

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDR 1959
             +  +      K +   L +    + V ++    ++ + S  +  ++      +NA W  
Sbjct: 157  QKKIT----ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRS 212

Query: 1960 INRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSLD----LE 2012
            I++  S+R+   +      +QF  DL     W+TEAE    +L D       L+    ++
Sbjct: 213  IHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVK 272

Query: 2013 KARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS-FLKEKLAGLNQRWDAIVAE 2071
            +     Q+L+  I +H   +  L+     I++ L  +D +  L+ +L  +N +W  +  +
Sbjct: 273  ELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332

Query: 2072 VKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEV 2131
              + +  L+  S Q  +    L E++ WL   +  + +++   +G +   ++   ++ +V
Sbjct: 333  SLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA--PIGGDFPAVQ---KQNDV 387

Query: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
            H    + L   E  ++S              +L TV +    +  +    L++  QEP  
Sbjct: 388  HRAFKRELKTKEPVIMS--------------TLETVRIF---LTEQPLEGLEKLYQEPRE 430

Query: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISI--PADLDKTITELADWLVLIDQM- 2248
            +     A   NV + +L   A ++  +  + +  S      +D+T+  L +     D++ 
Sbjct: 431  LPPEERA--QNVTR-LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELD 487

Query: 2249 --------LKSNIVTVGD--VEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                    +K +   VGD  ++ +   + ++K  + ++      + +V  LA+ L     
Sbjct: 488  LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGI 547

Query: 2299 SSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333
                    T  LE +  +W   Q  VE R +QL +
Sbjct: 548  QLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 100/541 (18%), Positives = 198/541 (36%), Gaps = 92/541 (17%)

Query: 1946 IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWIT---EAEELLVDT 2002
            I D + ++  +WD +     +R+          +Q +  L D TQW+    EAE++L   
Sbjct: 90   ITDRIERIQNQWDEVQEHLQNRR----------QQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 2003 CAPGGSLD--------LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             A   S          ++K     ++L   +   Q +    N     +++  S  D   +
Sbjct: 140  RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV 199

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAM 2107
                  +N  W +I   V +R+  L+   + + ++   L++ + WLT+AE        A 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 259

Query: 2108 QKRSTTELGENLQEL----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERD 2158
            +K    E  + ++EL    +DL  E+E H +    L+    ++L     SD ++ L  R 
Sbjct: 260  RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR- 318

Query: 2159 KISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQ 2218
                 L  +N  W+++ ++                                     + ++
Sbjct: 319  -----LDNMNFKWSELRKK------------------------------------SLNIR 337

Query: 2219 SHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQ 2278
            SH  +       L  ++ EL  WL L D  L       GD   + K     +  K +L+ 
Sbjct: 338  SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 397

Query: 2279 RHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS 2338
            + P +       +    +     +     E  E      +  Q+   L ++Q E++   +
Sbjct: 398  KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---N 452

Query: 2339 LQWDDHREETEELMRKYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFD 2395
             +W+     + +  RK +  L  LQ  Q   D L  ++   +++     P GD ++ +  
Sbjct: 453  TEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQ 512

Query: 2396 NVLQKLLEEYG-----SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRR 2450
            + L+K+    G      ++  +V +    L T  I L          L   W+ +Q +  
Sbjct: 513  DHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVE 572

Query: 2451 D 2451
            D
Sbjct: 573  D 573



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 95/519 (18%), Positives = 212/519 (40%), Gaps = 71/519 (13%)

Query: 1637 RTWTE--DWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV 1694
            R WTE  DW + L        +  G++  I+  + + +A + ++E++    +E I     
Sbjct: 17   RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA--- 73

Query: 1695 SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQE 1754
                      +N++++           +R ++  ++  +   +++V +H+++ +     +
Sbjct: 74   ---------AQNLKNKT------SNQEARTIITDRIERIQNQWDEVQEHLQNRR-----Q 113

Query: 1755 PLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVL 1813
             L + L  +  +        LE  E + E +L      LES  E    +D    +I E  
Sbjct: 114  QLNEMLKDSTQW--------LEAKE-EAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 164

Query: 1814 QRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSL 1867
            Q  +++       +    + L+LL  ++  +  K   I +      R + +  S   ++L
Sbjct: 165  QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 224

Query: 1868 LPTDYLVE-----INKILLCMDDVELSLNVPELNTA---IYEDFSFQEDSLKNIKDQLDK 1919
              T  L++     + K L  + + E + NV +  T    + ED    ++ +K  +D   +
Sbjct: 225  EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 284

Query: 1920 LGEQIAVIH---EKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAM 1975
            +     V H   E    ++    G + A+ ++  L  +N KW  + +   + +   + + 
Sbjct: 285  IEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASS 344

Query: 1976 EEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAAL 2035
            ++W++ H  L +L  W+   ++ L      GG          Q++ +V       +F   
Sbjct: 345  DQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRE 394

Query: 2036 NRTGDGIVQKLSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLD 2094
             +T + ++    +    FL E+ L GL    + +  E ++  P  + ++   +  R Q +
Sbjct: 395  LKTKEPVIMSTLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAE 449

Query: 2095 EIIC-WLTKAEHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
            E+   W     H+   +R   E  E LQEL++ T E+++
Sbjct: 450  EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 488



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 106/574 (18%), Positives = 231/574 (40%), Gaps = 67/574 (11%)

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  L+N  
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1616 EGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIFDGNVA 1662
               E   I+ +R+  +   W  V+   ++     N ++    Q         ++     A
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1663 HISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSS 1722
             + +W  +    +D I+KK T       K+L  +L      V+   D AL L+    +  
Sbjct: 142  KLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRDYSADD 195

Query: 1723 RELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
               V      +N ++  + + +  + A L      L Q  +  E F   +  ++ E   N
Sbjct: 196  TRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTAN 253

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ----L 1836
             +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+     
Sbjct: 254  VLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1837 LLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMDDVELS 1889
            +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + D ELS
Sbjct: 313  VLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1890 LNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGP 1941
               P        +    ++  F   +  LK  +  +    E + +   +QP   LE    
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 426

Query: 1942 EAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDL 1988
            E  +             +R    ++N +W+++N   +D +   D  +E  ++     ++L
Sbjct: 427  EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 486

Query: 1989 TQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048
               + +A E++  +  P G L ++  + H ++++       P    ++   D + ++L+ 
Sbjct: 487  DLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LARQLTT 544

Query: 2049 AD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
                   +    L  LN RW  +   V+DR  +L
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 578



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 108/599 (18%), Positives = 232/599 (38%), Gaps = 104/599 (17%)

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL- 1293
            W EL       T WL+ L++ +KS  V+    + +NE +   ++ ++     R Q+ EL 
Sbjct: 19   WTEL-------TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 1294 --GQTLIDGGILDD---IISEKLEAFNSRYEDLSHLAESKQISLEKQL----QVLRETDQ 1344
               Q L +     +   II++++E   ++++++    ++++  L + L    Q L   ++
Sbjct: 72   TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 131

Query: 1345 MLQVLQESLGELDK-QLTTYLTDRI-----DAFQVPQEAQKIQAEIS-AHELTLEELRR- 1396
              QVL ++  +L+  +   Y  D I     +  Q+ ++ ++ Q  +  A++L L+ LR  
Sbjct: 132  AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 1397 --------NMRSQPLT----SPESRTARGGSQMDVLQRKLREVSTKFQLF-------QKP 1437
                    +M ++ +     S   R +   + ++   R L++     + F       +  
Sbjct: 192  SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 251

Query: 1438 ANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIK 1497
            AN  Q     +R+L+  K    ++         I+ H D    +Y  L E   ++     
Sbjct: 252  ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD----VYHNLDENSQKI----- 302

Query: 1498 TGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLS 1557
                +   + +D+   +  +L ++   +++L  +    +  LE +S   +++      L 
Sbjct: 303  ----LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL 358

Query: 1558 EWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLI 1615
             WL   + EL +++   G    +  +    +   ++L+ ++  + +  E+      +  +
Sbjct: 359  VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 418

Query: 1616 EGSEPILEE--------------RLC-----VLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
            EG E + +E              RL       +N  W ++   + DW   +     +L+ 
Sbjct: 419  EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQE 478

Query: 1657 FDGNVAHISTWLYQAE---------------ALLDEIEK--------KPTSKQEEIVKRL 1693
                   +   L QAE               +L D +EK         P  +    V  L
Sbjct: 479  LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDL 538

Query: 1694 VSELDDANLQVENVRDQALILMNARGSSSRELVEPK---LAELNRNFEKVSQHIKSAKL 1749
              +L    +Q+       L  +N R    +  VE +   L E +R+F   SQH  S  +
Sbjct: 539  ARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSV 597


>gi|5032307 dystrophin Dp140c isoform [Homo sapiens]
          Length = 1105

 Score = 1153 bits (2982), Expect = 0.0
 Identities = 562/962 (58%), Positives = 726/962 (75%), Gaps = 11/962 (1%)

Query: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
            E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ + + K T  DLEQR PQL
Sbjct: 8    EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 67

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
            + + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ R+QQL +M+ DS QW +
Sbjct: 68   EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 127

Query: 2344 HREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             +EE E+++ +  A+L   ++     D + K+I++ + L ++L      V   +++  KL
Sbjct: 128  AKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 187

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
            L +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R +Q    DLE FL W+ E
Sbjct: 188  LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 2462 AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALG 2521
            AETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D++ ++D N QK++++L 
Sbjct: 248  AETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLE 307

Query: 2522 NSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEE 2581
             S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL +SL+EL+ WL +KD+E
Sbjct: 308  GSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 367

Query: 2582 LKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRN 2641
            L +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R+FL +QP+E  E   + 
Sbjct: 368  LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE---KL 424

Query: 2642 LQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD 2701
             Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+++D+ LE+L++LQ A D
Sbjct: 425  YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 484

Query: 2702 DLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
            +LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP+   V  VNDL+ QL+ 
Sbjct: 485  ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 544

Query: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821
            L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 604

Query: 2822 ISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLL 2881
            IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL
Sbjct: 605  ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 664

Query: 2882 ELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLN 2941
             LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLN
Sbjct: 665  SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 724

Query: 2942 VYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQI 3001
            VYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQI
Sbjct: 725  VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 784

Query: 3002 PRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAA 3061
            PRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAA
Sbjct: 785  PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 844

Query: 3062 ETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTT 3121
            ETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTT
Sbjct: 845  ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 904

Query: 3122 SGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQ 3181
            SGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQ      NL+     +    EH   S 
Sbjct: 905  SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ------NLQAEYDRLKQQHEHKGLSP 958

Query: 3182 SP 3183
             P
Sbjct: 959  LP 960



 Score =  167 bits (422), Expect = 2e-40
 Identities = 94/162 (58%), Positives = 117/162 (72%), Gaps = 6/162 (3%)

Query: 3275 RNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQ 3333
            +NLQ EY++LK QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQ
Sbjct: 938  QNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 997

Query: 3334 ILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFH 3390
            ILEDHNKQLESQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q  
Sbjct: 998  ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 1057

Query: 3391 QAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
             + G EDLL+PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 1058 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 1099



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 117/589 (19%), Positives = 260/589 (44%), Gaps = 68/589 (11%)

Query: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP 743
            +++ A   F+    EL +W+      I++  +     ++D +EM  K KA  ++  +R P
Sbjct: 7    LEVPALADFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRP 65

Query: 744  RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINA 802
            + +EL    Q L  +   +   T  I + +E++ ++W  V +HL++  +++ ++ +D   
Sbjct: 66   QLEELITAAQNLKNKTSNQEARTI-ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 124

Query: 803  YFKQLDELEKVIKTK----EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858
            + +  +E E+V+       E W +     ++ ++ +   K   +    +L      +++A
Sbjct: 125  WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK----DLRQWQTNVDVA 180

Query: 859  RASCSALMSQPSAPDF--VQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETL 916
                  L+   SA D   V    ++    ++++ + V +R+  LE            ET 
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE------------ETH 228

Query: 917  KTLKDVLNDSEN------KAQVSLNVLNDLAKVEKALQEKKTLDEIL----------ENQ 960
            + L+    D E       +A+ + NVL D  + E+ L++ K + E++          E  
Sbjct: 229  RLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAH 288

Query: 961  KPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLR 1019
                H L E ++ + +++   D   L ++  D++  KW++L+    K L++   +  +  
Sbjct: 289  TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR---KKSLNIRSHLEASSD 345

Query: 1020 AFEADSTVIEK---WMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES-SLKN 1075
             ++     +++   W+    D L +Q    GD   +Q+Q D   AF  E++T E   +  
Sbjct: 346  QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 405

Query: 1076 MKEIETNLRSGPVAGI-KTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEK----AANL 1130
            ++ +   L   P+ G+ K + + R    + + + +++ +  Q   ++   EK    +A+ 
Sbjct: 406  LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 465

Query: 1131 KKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV-RVKILKDNI 1189
            ++ + E  E + + +E   E D + +  E ++ + + +     D LQ  + +VK L+  I
Sbjct: 466  QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEI 525

Query: 1190 KLL---AAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
              L    + V    ++LT+ L + L  Y L          TLE++ + W
Sbjct: 526  APLKENVSHVNDLARQLTT-LGIQLSPYNL---------STLEDLNTRW 564



 Score = 86.3 bits (212), Expect = 5e-16
 Identities = 116/614 (18%), Positives = 250/614 (40%), Gaps = 71/614 (11%)

Query: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
           L  +  A  E+  WL   +   + Q  +  D+E++ +     +A M +L   +  +  ++
Sbjct: 12  LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430
            A   L  + T + E    I +++  +  +W+ ++    +R+ +L+++L +  +      
Sbjct: 72  TAAQNLKNK-TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ------ 124

Query: 431 SAWLTLTEERIQ-------KMETCPLDD-DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH 482
             WL   EE  Q       K+E+       V ++QK + E K L  DL   Q  V+    
Sbjct: 125 --WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 182

Query: 483 MVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLK 542
           + + +  +     T  +    + +   W ++ +   ER   L+E + L Q+   +     
Sbjct: 183 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 242

Query: 543 AWLTEKEEALNKVQTSNFK-----DQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV 597
           AWLTE E   N +Q +  K     D K +   +++   L+ ++E        L E  Q +
Sbjct: 243 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 598 GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
            + L+ S  +  +    + +  +W  L ++  +  + +  +  +     +  ++LL  ++
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 658 VREQAITKKSKQELPPPPPPKKRQIH--VDIEAKKKFDAISAELLNWILKWKTAIQTTEI 715
           +++  +++++      P   K+  +H     E K K   I + L                
Sbjct: 363 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL---------------- 406

Query: 716 KEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEK 775
            E +++  T +  + L+ L +E RE  P     N                T  ++   E+
Sbjct: 407 -ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQN---------------VTRLLRKQAEE 450

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLP 835
           V++EW+ ++ H  D +RK      I+   ++L EL++     +  ++   + + S Q + 
Sbjct: 451 VNTEWEKLNLHSADWQRK------IDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 504

Query: 836 SLK-DSCQRELTNLLGLHPKIEMARASCSAL--MSQPSAPDFVQRG------FDSFLGRY 886
            L  DS Q  L  +  L  +I   + + S +  +++      +Q         +    R+
Sbjct: 505 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 564

Query: 887 QAVQEAVEDRQQHL 900
           + +Q AVEDR + L
Sbjct: 565 KLLQVAVEDRVRQL 578



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
           +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 218 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 277

Query: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
            +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 278 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 336

Query: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
           +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 337 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 394

Query: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
           L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 395 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 454

Query: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
           W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 455 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 514

Query: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
            E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 515 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 565

Query: 623 SLVQRLEDSSNQVTQAVAKLG 643
            L   +ED   Q+ +A    G
Sbjct: 566 LLQVAVEDRVRQLHEAHRDFG 586



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 114/635 (17%), Positives = 254/635 (40%), Gaps = 79/635 (12%)

Query: 1721 SSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
            SS  L  P LA+ NR + +++  +     +I  +               V   DLE    
Sbjct: 3    SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR--------------VMVGDLE---- 44

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
            DI  M+      ++     + +++   Q+EE++   + + ++      +  I  ++  + 
Sbjct: 45   DINEMI------IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 98

Query: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKIL-LCMDDVELSLNVPELNTAI 1899
             ++++++   +Q R+  QL   ++ S    +   E  ++L      +E     P    AI
Sbjct: 99   NQWDEVQE-HLQNRRQ-QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 156

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDR 1959
             +  +      K +   L +    + V ++    ++ + S  +  ++      +NA W  
Sbjct: 157  QKKIT----ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRS 212

Query: 1960 INRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSLD----LE 2012
            I++  S+R+   +      +QF  DL     W+TEAE    +L D       L+    ++
Sbjct: 213  IHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVK 272

Query: 2013 KARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS-FLKEKLAGLNQRWDAIVAE 2071
            +     Q+L+  I +H   +  L+     I++ L  +D +  L+ +L  +N +W  +  +
Sbjct: 273  ELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332

Query: 2072 VKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEV 2131
              + +  L+  S Q  +    L E++ WL   +  + +++   +G +   ++   ++ +V
Sbjct: 333  SLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA--PIGGDFPAVQ---KQNDV 387

Query: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
            H    + L   E  ++S              +L TV +    +  +    L++  QEP  
Sbjct: 388  HRAFKRELKTKEPVIMS--------------TLETVRIF---LTEQPLEGLEKLYQEPRE 430

Query: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISI--PADLDKTITELADWLVLIDQM- 2248
            +     A   NV + +L   A ++  +  + +  S      +D+T+  L +     D++ 
Sbjct: 431  LPPEERA--QNVTR-LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELD 487

Query: 2249 --------LKSNIVTVGD--VEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                    +K +   VGD  ++ +   + ++K  + ++      + +V  LA+ L     
Sbjct: 488  LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGI 547

Query: 2299 SSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333
                    T  LE +  +W   Q  VE R +QL +
Sbjct: 548  QLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 100/541 (18%), Positives = 198/541 (36%), Gaps = 92/541 (17%)

Query: 1946 IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWIT---EAEELLVDT 2002
            I D + ++  +WD +     +R+          +Q +  L D TQW+    EAE++L   
Sbjct: 90   ITDRIERIQNQWDEVQEHLQNRR----------QQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 2003 CAPGGSLD--------LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             A   S          ++K     ++L   +   Q +    N     +++  S  D   +
Sbjct: 140  RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV 199

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAM 2107
                  +N  W +I   V +R+  L+   + + ++   L++ + WLT+AE        A 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 259

Query: 2108 QKRSTTELGENLQEL----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERD 2158
            +K    E  + ++EL    +DL  E+E H +    L+    ++L     SD ++ L  R 
Sbjct: 260  RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR- 318

Query: 2159 KISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQ 2218
                 L  +N  W+++ ++                                     + ++
Sbjct: 319  -----LDNMNFKWSELRKK------------------------------------SLNIR 337

Query: 2219 SHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQ 2278
            SH  +       L  ++ EL  WL L D  L       GD   + K     +  K +L+ 
Sbjct: 338  SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 397

Query: 2279 RHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS 2338
            + P +       +    +     +     E  E      +  Q+   L ++Q E++   +
Sbjct: 398  KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---N 452

Query: 2339 LQWDDHREETEELMRKYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFD 2395
             +W+     + +  RK +  L  LQ  Q   D L  ++   +++     P GD ++ +  
Sbjct: 453  TEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQ 512

Query: 2396 NVLQKLLEEYG-----SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRR 2450
            + L+K+    G      ++  +V +    L T  I L          L   W+ +Q +  
Sbjct: 513  DHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVE 572

Query: 2451 D 2451
            D
Sbjct: 573  D 573



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 95/519 (18%), Positives = 212/519 (40%), Gaps = 71/519 (13%)

Query: 1637 RTWTE--DWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV 1694
            R WTE  DW + L        +  G++  I+  + + +A + ++E++    +E I     
Sbjct: 17   RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA--- 73

Query: 1695 SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQE 1754
                      +N++++           +R ++  ++  +   +++V +H+++ +     +
Sbjct: 74   ---------AQNLKNKT------SNQEARTIITDRIERIQNQWDEVQEHLQNRR-----Q 113

Query: 1755 PLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVL 1813
             L + L  +  +        LE  E + E +L      LES  E    +D    +I E  
Sbjct: 114  QLNEMLKDSTQW--------LEAKE-EAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 164

Query: 1814 QRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSL 1867
            Q  +++       +    + L+LL  ++  +  K   I +      R + +  S   ++L
Sbjct: 165  QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 224

Query: 1868 LPTDYLVE-----INKILLCMDDVELSLNVPELNTA---IYEDFSFQEDSLKNIKDQLDK 1919
              T  L++     + K L  + + E + NV +  T    + ED    ++ +K  +D   +
Sbjct: 225  EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 284

Query: 1920 LGEQIAVIH---EKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAM 1975
            +     V H   E    ++    G + A+ ++  L  +N KW  + +   + +   + + 
Sbjct: 285  IEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASS 344

Query: 1976 EEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAAL 2035
            ++W++ H  L +L  W+   ++ L      GG          Q++ +V       +F   
Sbjct: 345  DQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRE 394

Query: 2036 NRTGDGIVQKLSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLD 2094
             +T + ++    +    FL E+ L GL    + +  E ++  P  + ++   +  R Q +
Sbjct: 395  LKTKEPVIMSTLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAE 449

Query: 2095 EIIC-WLTKAEHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
            E+   W     H+   +R   E  E LQEL++ T E+++
Sbjct: 450  EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 488



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 106/574 (18%), Positives = 231/574 (40%), Gaps = 67/574 (11%)

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L++WLS  +  +  +    G L D++  I   K  ++DLE+R+  L  +  ++  L+N  
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1616 EGSE--PILEERLCVLNAGWSRVRTWTED---WCNTLMNHQNQL--------EIFDGNVA 1662
               E   I+ +R+  +   W  V+   ++     N ++    Q         ++     A
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1663 HISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSS 1722
             + +W  +    +D I+KK T       K+L  +L      V+   D AL L+    +  
Sbjct: 142  KLESW-KEGPYTVDAIQKKITE-----TKQLAKDLRQWQTNVDVANDLALKLLRDYSADD 195

Query: 1723 RELVEPKLAELNRNFEKVSQHI--KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
               V      +N ++  + + +  + A L      L Q  +  E F   +  ++ E   N
Sbjct: 196  TRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTAN 253

Query: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ----L 1836
             +++  +  E+ LE S   +++ ++   ++  ++   ++ H   E+++K    L+     
Sbjct: 254  VLQDATR-KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1837 LLLHTRYNKIKAIPIQQRKMGQLASGIRSSL-LPTDYLVEINKIL------LCMDDVELS 1889
            +LL  R + +     +  ++ + +  IRS L   +D    ++  L      L + D ELS
Sbjct: 313  VLLQRRLDNMN---FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1890 LNVP--------ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGP 1941
               P        +    ++  F   +  LK  +  +    E + +   +QP   LE    
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAF---KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 426

Query: 1942 EAIQ-------------IRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDL 1988
            E  +             +R    ++N +W+++N   +D +   D  +E  ++     ++L
Sbjct: 427  EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 486

Query: 1989 TQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048
               + +A E++  +  P G L ++  + H ++++       P    ++   D + ++L+ 
Sbjct: 487  DLKLRQA-EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVND-LARQLTT 544

Query: 2049 AD---GSFLKEKLAGLNQRWDAIVAEVKDRQPRL 2079
                   +    L  LN RW  +   V+DR  +L
Sbjct: 545  LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 578



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 108/599 (18%), Positives = 232/599 (38%), Gaps = 104/599 (17%)

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL- 1293
            W EL       T WL+ L++ +KS  V+    + +NE +   ++ ++     R Q+ EL 
Sbjct: 19   WTEL-------TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 71

Query: 1294 --GQTLIDGGILDD---IISEKLEAFNSRYEDLSHLAESKQISLEKQL----QVLRETDQ 1344
               Q L +     +   II++++E   ++++++    ++++  L + L    Q L   ++
Sbjct: 72   TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 131

Query: 1345 MLQVLQESLGELDK-QLTTYLTDRI-----DAFQVPQEAQKIQAEIS-AHELTLEELRR- 1396
              QVL ++  +L+  +   Y  D I     +  Q+ ++ ++ Q  +  A++L L+ LR  
Sbjct: 132  AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 1397 --------NMRSQPLT----SPESRTARGGSQMDVLQRKLREVSTKFQLF-------QKP 1437
                    +M ++ +     S   R +   + ++   R L++     + F       +  
Sbjct: 192  SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 251

Query: 1438 ANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIK 1497
            AN  Q     +R+L+  K    ++         I+ H D    +Y  L E   ++     
Sbjct: 252  ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD----VYHNLDENSQKI----- 302

Query: 1498 TGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLS 1557
                +   + +D+   +  +L ++   +++L  +    +  LE +S   +++      L 
Sbjct: 303  ----LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL 358

Query: 1558 EWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLI 1615
             WL   + EL +++   G    +  +    +   ++L+ ++  + +  E+      +  +
Sbjct: 359  VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 418

Query: 1616 EGSEPILEE--------------RLC-----VLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
            EG E + +E              RL       +N  W ++   + DW   +     +L+ 
Sbjct: 419  EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQE 478

Query: 1657 FDGNVAHISTWLYQAE---------------ALLDEIEK--------KPTSKQEEIVKRL 1693
                   +   L QAE               +L D +EK         P  +    V  L
Sbjct: 479  LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDL 538

Query: 1694 VSELDDANLQVENVRDQALILMNARGSSSRELVEPK---LAELNRNFEKVSQHIKSAKL 1749
              +L    +Q+       L  +N R    +  VE +   L E +R+F   SQH  S  +
Sbjct: 539  ARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSV 597


>gi|5032297 dystrophin Dp71 isoform [Homo sapiens]
          Length = 617

 Score =  892 bits (2304), Expect = 0.0
 Identities = 439/604 (72%), Positives = 501/604 (82%), Gaps = 6/604 (0%)

Query: 2833 HQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQ 2892
            H+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   Q
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 2893 HKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIR 2952
            H L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 2953 VQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFG 3012
            V S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3013 GSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3072
            GSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3073 CKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKV 3132
            CKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3133 LKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHS 3192
            LKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ETP+TLI+ WP    P+ SPQL HDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367

Query: 3193 RIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQIL 3252
            RIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP+SQP+SPAQIL
Sbjct: 368  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427

Query: 3253 KSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSED 3311
             S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE + +   +  D
Sbjct: 428  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPW 3368
            +ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++++NG    SP 
Sbjct: 488  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547

Query: 3369 ASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPSC-CPNV 3426
             S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++++FPS    N 
Sbjct: 548  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 607

Query: 3427 PSRP 3430
            P +P
Sbjct: 608  PGKP 611



 Score = 35.4 bits (80), Expect = 0.98
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 719 MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
           ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 430 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 489

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
           + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 490 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 549

Query: 835 PSLKDSCQRELTNLLG 850
               DS Q  L  ++G
Sbjct: 550 LQRSDSSQPMLLRVVG 565


>gi|5032299 dystrophin Dp71b isoform [Homo sapiens]
          Length = 635

 Score =  890 bits (2300), Expect = 0.0
 Identities = 436/594 (73%), Positives = 497/594 (83%), Gaps = 5/594 (0%)

Query: 2833 HQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQ 2892
            H+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   Q
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 2893 HKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIR 2952
            H L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 2953 VQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFG 3012
            V S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3013 GSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3072
            GSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3073 CKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKV 3132
            CKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3133 LKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHS 3192
            LKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ETP+TLI+ WP    P+ SPQL HDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367

Query: 3193 RIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQIL 3252
            RIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP+SQP+SPAQIL
Sbjct: 368  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427

Query: 3253 KSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSED 3311
             S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE + +   +  D
Sbjct: 428  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPW 3368
            +ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++++NG    SP 
Sbjct: 488  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547

Query: 3369 ASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPS 3421
             S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++++FPS
Sbjct: 548  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS 601



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 42/196 (21%), Positives = 74/196 (37%), Gaps = 24/196 (12%)

Query: 719 MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
           ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 430 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 489

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
           + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 490 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 549

Query: 835 PSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVE 894
               DS Q  L  ++G      M                    G +  L   Q     +E
Sbjct: 550 LQRSDSSQPMLLRVVGSQTSDSM--------------------GEEDLLSPPQDTSTGLE 589

Query: 895 DRQQHLENELKGQPGH 910
           +  + L N      GH
Sbjct: 590 EVMEQLNNSFPSSRGH 605


>gi|148539558 dystrophin related protein 2 [Homo sapiens]
          Length = 957

 Score =  884 bits (2284), Expect = 0.0
 Identities = 458/890 (51%), Positives = 618/890 (69%), Gaps = 29/890 (3%)

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPAL 2595
            MN  WN++K KS ++RA LEA ++   +L + L+E+I WL+ KDEEL  Q+P+ GDV  +
Sbjct: 79   MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALV 138

Query: 2596 QLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQ 2655
            Q + +   A   E+K +   + + ++ A+ FL+  P E  EEP    +SK + +P++R Q
Sbjct: 139  QQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHS--ESK-DTSPKQRIQ 195

Query: 2656 KIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRN 2715
             +++ + KQ++   E WE L A   +  + +++ LE+L ++QGAM++L   + +AE VR 
Sbjct: 196  NLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRA 255

Query: 2716 GWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLD 2775
             W+P+GDL IDSL +HI+ I  F+EE +P+   VK VNDL+ QL+  D+H S++ S+ L+
Sbjct: 256  TWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALE 315

Query: 2776 DLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYINHQT 2835
             +N+RWK LQ SV +RLKQLQ+AHRDFGP SQHFLS+SVQ+PW+R+IS NKVPYYINHQ 
Sbjct: 316  QINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQA 375

Query: 2836 QTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKL 2895
            QTTCWDHPKMTEL+Q+LADLNN++FSAYRTA+K+RR+QKAL LDL+ L+T  EIF +H L
Sbjct: 376  QTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDL 435

Query: 2896 NQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIRVQS 2955
              ++ ++ V +VI+CLT  Y+ LE+    LVNVPLCVDM LNWLLNV+D+GR+GK+R  S
Sbjct: 436  QASEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALS 495

Query: 2956 LKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSN 3015
             K G+  L    ++EK +YLF +VA     CDQR LG+LLH+AIQ+PRQLGEVAAFGGSN
Sbjct: 496  FKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSN 555

Query: 3016 IEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNICKE 3075
            +EPSVRSCF+ +  KP I   +F++W++LEPQSMVWL VLHRV  AE  KHQ KC+IC++
Sbjct: 556  VEPSVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQ 615

Query: 3076 CPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKVLKN 3135
            CPI GFRYRSLK FN D+CQ+CF +GR +KG+KLHYP++EY  PTTS E++RDF   LKN
Sbjct: 616  CPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKN 675

Query: 3136 KFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHSRIE 3195
            KFRSK YF+KHP+ GYLPVQ+VLE D  ETP +   MWP            H DTHSRIE
Sbjct: 676  KFRSKHYFSKHPQRGYLPVQSVLEADYSETPAS-SPMWP------------HADTHSRIE 722

Query: 3196 QYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSV 3255
             +A+RLA+ME  N SF  DS S   S++++  L+ ++   +    P    Q+P     SV
Sbjct: 723  HFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLL-RHSSPITDREPAFGQQAPC----SV 777

Query: 3256 EREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRG-LPVGSPPESIISPHHTSEDSEL 3314
              E +GEL++I+A LE+E R LQ E  +LK QH      P  +   +  +  H +E  EL
Sbjct: 778  ATESKGELQKILAHLEDENRILQGELRRLKWQHEEAAEAPSLADGSTEAATDHRNE--EL 835

Query: 3315 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP--ESD-SRINGVSPWASP 3371
            +AEA++LRQHK RLE RMQILEDHNKQLESQL RLR+LL QP  ESD S   G S  +SP
Sbjct: 836  LAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSP 895

Query: 3372 QHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFPS 3421
            Q S  S+  +   + P     A +D+ +   D S  L ++ME++   FPS
Sbjct: 896  QQSEGSHPREKGQTTPD--TEAADDVGSKSQDVSLCLEDIMEKLRHAFPS 943



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 55/239 (23%), Positives = 106/239 (44%), Gaps = 36/239 (15%)

Query: 315 QIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGN 374
           Q+ L+E++ WL   ++    Q  +  DV  V+ +  TH AFM E+ +    + SVL++  
Sbjct: 108 QLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQ 167

Query: 375 QLITQGTLSDEEEFE------------------IQEQMTLLNARWEALRVESMDRQSRLH 416
             ++Q    + EE                    + +Q T+ +  WE L    +D+   + 
Sbjct: 168 AFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIE 227

Query: 417 DVLMELQKKQ--LQQLSAWLTLTE------ERIQKMETCPLDDDVKSLQKLLEEHKSLQS 468
             L +L + Q  +++LS  L+  E      E I  +    L + +++++   EE   ++ 
Sbjct: 228 RTLEQLLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKD 287

Query: 469 DLEAEQVKVNSLTHMVVIVDEN-SGESATAILEDQLQKLGERWTAVCRWTEERWNRLQE 526
            ++     VN L H + I D + S E++ A     L+++  RW  +     ER  +LQ+
Sbjct: 288 GVKL----VNDLAHQLAISDVHLSMENSQA-----LEQINVRWKQLQASVSERLKQLQD 337


>gi|5032301 dystrophin Dp71a isoform [Homo sapiens]
          Length = 604

 Score =  869 bits (2245), Expect = 0.0
 Identities = 433/604 (71%), Positives = 493/604 (81%), Gaps = 19/604 (3%)

Query: 2833 HQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQ 2892
            H+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   Q
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 2893 HKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIR 2952
            H L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 2953 VQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFG 3012
            V S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3013 GSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3072
            GSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3073 CKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKV 3132
            CKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3133 LKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHS 3192
            LKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ET             P+ SPQL HDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354

Query: 3193 RIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQIL 3252
            RIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP+SQP+SPAQIL
Sbjct: 355  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414

Query: 3253 KSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSED 3311
             S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE + +   +  D
Sbjct: 415  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPW 3368
            +ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++++NG    SP 
Sbjct: 475  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534

Query: 3369 ASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPSC-CPNV 3426
             S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++++FPS    N 
Sbjct: 535  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 594

Query: 3427 PSRP 3430
            P +P
Sbjct: 595  PGKP 598



 Score = 35.4 bits (80), Expect = 0.98
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 719 MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
           ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 417 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 476

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
           + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 477 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 536

Query: 835 PSLKDSCQRELTNLLG 850
               DS Q  L  ++G
Sbjct: 537 LQRSDSSQPMLLRVVG 552


>gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]
          Length = 622

 Score =  867 bits (2241), Expect = 0.0
 Identities = 430/594 (72%), Positives = 489/594 (82%), Gaps = 18/594 (3%)

Query: 2833 HQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQ 2892
            H+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   Q
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 2893 HKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIR 2952
            H L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 2953 VQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFG 3012
            V S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3013 GSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3072
            GSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3073 CKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKV 3132
            CKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3133 LKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHS 3192
            LKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ET             P+ SPQL HDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354

Query: 3193 RIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQIL 3252
            RIE YA+RLA+ME +NGS+L DS S   S++DEH LIQ YCQ+L  +SP+SQP+SPAQIL
Sbjct: 355  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414

Query: 3253 KSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSED 3311
             S+E EERGELERI+ADLEEE RNLQ EY++LK QH  +GL P+ SPPE + +   +  D
Sbjct: 415  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPW 3368
            +ELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP++++++NG    SP 
Sbjct: 475  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534

Query: 3369 ASPQHSALSYSLDPDASGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPS 3421
             S Q S  S  +     G Q   + G EDLL+PP DTST L EVMEQ++++FPS
Sbjct: 535  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS 588



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 42/196 (21%), Positives = 74/196 (37%), Gaps = 24/196 (12%)

Query: 719 MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
           ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 417 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 476

Query: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
           + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 477 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 536

Query: 835 PSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVE 894
               DS Q  L  ++G      M                    G +  L   Q     +E
Sbjct: 537 LQRSDSSQPMLLRVVGSQTSDSM--------------------GEEDLLSPPQDTSTGLE 576

Query: 895 DRQQHLENELKGQPGH 910
           +  + L N      GH
Sbjct: 577 EVMEQLNNSFPSSRGH 592


>gi|5032305 dystrophin Dp40 isoform [Homo sapiens]
          Length = 340

 Score =  579 bits (1492), Expect = e-164
 Identities = 271/333 (81%), Positives = 296/333 (88%)

Query: 2833 HQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQ 2892
            H+TQTTCWDHPKMTEL+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS   +   Q
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 2893 HKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIR 2952
            H L QNDQ + +  +INCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 2953 VQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFG 3012
            V S K G++SL K  LE+KYRYLFK+VA  T  CDQR+LGLLLHD+IQIPRQLGEVA+FG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3013 GSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3072
            GSNIEPSVRSCFQ  NNKPEI    F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3073 CKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKV 3132
            CKECPI+GFRYRSLKHFNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3133 LKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLET 3165
            LKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+ET
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 340


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  315 bits (808), Expect = 4e-85
 Identities = 536/2784 (19%), Positives = 1118/2784 (40%), Gaps = 354/2784 (12%)

Query: 207  PIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSL---FEVLPQQVTIDAI 263
            P + + H F + Q     E  L+ ED    L   + ++  L+S     ++   Q  +  +
Sbjct: 2685 PDQDITHFFQQIQ-----ELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL 2739

Query: 264  REVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDSYQIAL 318
            R+  T  +K  KE E++A + Q    E        +    ET  ++   +  + + +  L
Sbjct: 2740 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE--L 2797

Query: 319  EEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTA--HQSSVGSVLQAGNQL 376
            E+ +  L S  D +  +  +   VEE+  +  + E  +ME+TA   Q   GS+L +    
Sbjct: 2798 EKQIEHLKSLLDDWASKGTL---VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSS 2854

Query: 377  I--TQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQLQQLSA 432
            +    G  + ++  EIQ  M+ +N ++E L     +RQ  L  +L  ME   K+   +  
Sbjct: 2855 VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQ 2914

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV---VIVDE 489
            WL   EE ++ M+        ++++   E +K+  ++LE    K+  +   +   ++   
Sbjct: 2915 WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2974

Query: 490  NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEE-----------Q 538
            NS E+             E W  +      RW R  E+ +  Q  LEE           +
Sbjct: 2975 NSQEA-------------ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 3021

Query: 539  CLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV- 597
              L+ WL EKE  +  +   +  D   L+   +++  + ++ E +RQ  +QL+E  Q + 
Sbjct: 3022 SQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080

Query: 598  ---GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654
               G   D S ++ ++  + + + Q+W  L  +L   S+Q+ QA+ K    Q   +DL E
Sbjct: 3081 TGPG---DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSE 3137

Query: 655  TVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTE 714
             VR   Q ++ +S   +   P   K+Q+    E +   + +  E    + + +T      
Sbjct: 3138 KVRAVGQRLSVQS--AISTQPEAVKQQLEETSEIRSDLEQLDHE----VKEAQTLCDELS 3191

Query: 715  I---KEYMKMQDTSEMKKKLK--ALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEI 769
            +   ++Y+K     E+KK+L+  AL  +  E +  AD +N+    L      + +  E  
Sbjct: 3192 VLIGEQYLK----DELKKRLETVALPLQGLEDL-AADRINRLQAALASTQQFQQMFDELR 3246

Query: 770  KNVLEKVSSEWKN--VSQHLEDLERKIQ----LQEDINAYFKQLDEL------------- 810
              + +K S + KN  +S  LE L+ ++Q     Q+ +N +    + +             
Sbjct: 3247 TWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306

Query: 811  --------EKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASC 862
                     ++++ K  W + +  +   +  L       Q+   ++  L P IE  +A  
Sbjct: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM 3366

Query: 863  SALM-----------------------SQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQH 899
            S L                         + S  + +    D  +   +A ++ + D +  
Sbjct: 3367 SELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAG 3426

Query: 900  LE-------NELKGQPG---------HAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKV 943
            +         EL+ + G           + E+ K ++  +  ++++ ++  + L   A  
Sbjct: 3427 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQACS 3485

Query: 944  EKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPD---------VEKLYKQEFDDVQ 994
             K L++ +   E+L+  +P +  L   T+ L ++  PD           ++ +QEF +V+
Sbjct: 3486 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA-PDGSDASQLLHQAEVAQQEFLEVK 3544

Query: 995  GKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQR 1054
             + N   V++   L  + +    +R   +    ++  +DG+        A   D   LQ 
Sbjct: 3545 QRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM-------GAIGRDTDSLQS 3597

Query: 1055 QLDQCSAFVN-------EIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLE 1107
            Q++    F+N       +IE  E+  ++M E E  L    + G+K      L     Q  
Sbjct: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL---DLLGLK----RELEALNKQCG 3650

Query: 1108 KLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEE 1167
            KL++    ++ +L  +  +  +  + L  + +  T AEE       ++    E+E   ++
Sbjct: 3651 KLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEE---AEALQWVVGTEVEIINQQ 3707

Query: 1168 MKRAKEDVLQKE----VRVKILKDNIKLLAAKVPSGG-----QELTSELNVVLENYQLLC 1218
            +   K  + QKE    +++K+ + N  L    + S G     Q L  ++  +   +  L 
Sbjct: 3708 LADFK--MFQKEQVDPLQMKLQQVN-GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764

Query: 1219 NRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLES 1278
             ++  +   L+E      +    L+   +WL   EE + + +    +   V   ++  + 
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824

Query: 1279 VLRHPADNRTQI----RELGQTLIDGGILD-DIISEKLEAFNSRYEDLSHLAESKQISLE 1333
            + R   D +  +     E G+      + D + I+ +LE+  SR+ +L   A ++Q  LE
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884

Query: 1334 KQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEE 1393
              L + ++  +  + + + L   +K+L        ++  V  +  KIQ +I  H+   E+
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLA-------NSEPVGTQTAKIQQQIIRHKALEED 3937

Query: 1394 LRRNMR--------SQPLTSPESRTARG--GSQMDVLQRKLREVSTKF--------QLFQ 1435
            +  +           Q L+S  S   +G    ++D LQ +  E+  +         Q   
Sbjct: 3938 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3997

Query: 1436 KPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETV 1495
                F +  ++    L  V+ +L  + VKD   DV+       + L + +   K  V+  
Sbjct: 3998 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 4057

Query: 1496 IKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAAS 1555
            IK G+ ++++   +    + E+L  +K  Y D+    ++  + LE+A QLA K +     
Sbjct: 4058 IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 4117

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L+ WL   E EL            +       K + K++ + +  L+T+ E S AL  L+
Sbjct: 4118 LTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 4177

Query: 1616 -----EGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQ 1670
                 EG + ++ +           +    ++    +   Q   +  D  +A ++    +
Sbjct: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRK 4237

Query: 1671 AEALLD-EIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPK 1729
              AL    +E+  T+ Q ++ K    ++      ++ +      +    G   + +++ K
Sbjct: 4238 LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 4297

Query: 1730 LAELNRNFEKVS-------QHIKSAKLLIAQ-----EPLYQCLVTTETF--ETGVPFSDL 1775
               L + +E +S         ++ A++L+ Q     E L   +  T     +   P  D 
Sbjct: 4298 TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDH 4357

Query: 1776 EKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
            E+L    E M +  E   E     +K+ +   Q++E+     EM+ +  +  K E +   
Sbjct: 4358 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ--KAENM--- 4412

Query: 1836 LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPEL 1895
                   Y +IK   ++QR +  L   +  S   T++  +I  +L  ++++   L +P L
Sbjct: 4413 -------YAQIKE-EVRQRALA-LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 4463

Query: 1896 NTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPE----AIQIRDTLT 1951
              A  +         K+   +L+KL      +  +  ++I  + G +    A +I+D L 
Sbjct: 4464 IPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLD 4523

Query: 1952 QLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDL 2011
            Q+   W+ I     +R+  F   +E   +F  D+  L   I + ++++ D  +PG    +
Sbjct: 4524 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4583

Query: 2012 EKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVA 2070
             K ++   E ++            +   G  ++    + +   +++ +  +N  W+ +  
Sbjct: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK 4643

Query: 2071 EVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEM- 2129
              K+R  +L+   +  ++Y+  L  +  WL      ++  +   +G +L  ++D   EM 
Sbjct: 4644 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTDLNTVKDQLNEMK 4701

Query: 2130 ----EVHAEKLKW--LNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLK 2183
                EV+ ++++   LN  + E++  K+    +RD I E L  +   W  +  ++     
Sbjct: 4702 EFKVEVYQQQIEMEKLNH-QGELMLKKATDETDRDIIREPLTELKHLWENLGEKI----- 4755

Query: 2184 ECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLV 2243
                           AH                 Q      +         + EL  WL 
Sbjct: 4756 ---------------AHR----------------QHKLEGALLALGQFQHALEELMSWLT 4784

Query: 2244 LIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMR 2303
              +++L +     GD + I   +++  + K D+      ++ V   A N   ++S+ D  
Sbjct: 4785 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV-NKAGNELLESSAGDDA 4843

Query: 2304 TAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQ 2363
            +++  +LE +   W+      E R+QQL+  +  +  +    E+    + + E++L   +
Sbjct: 4844 SSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK 4903

Query: 2364 QARRDPLT--KQISDNQILLQELGPGDGIVMAFDNVLQK----LLEEYGSDDTRNVKETT 2417
                 P T  +Q+  +  L  +L   +     ++ +L K    LL    S      +++ 
Sbjct: 4904 PTGGLPETAREQLDTHMELYSQLKAKE---ETYNQLLDKGRLMLLSRDDSGSGSKTEQSV 4960

Query: 2418 EYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHREN 2477
              L+  W  +   + +R++ LE         +  L+ F+ W+  AE ++N+    S   N
Sbjct: 4961 ALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN 5020

Query: 2478 ALQDSILARELKQQMQDIQAEIDAHNDIFKSID--GNRQKMVKALGNSEEATMLQHRLDD 2535
             +   I      ++ +    E++AH D    +D  GN+   +K L   ++  ++++ L  
Sbjct: 5021 TVLSQI------EEHKVFANEVNAHRDQIIELDQTGNQ---LKFLSQKQDVVLIKNLLVS 5071

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPAL 2595
            +  RW  +  +S      L+ + ++  +   + ++LI WL   +  L  ++ I  D   +
Sbjct: 5072 VQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 5131

Query: 2596 QLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPI-EAPEEPRRNLQSKTELTPEERA 2654
            +LQ    K  ++ L  K                 QP+ +      R L+ KT L PE+ +
Sbjct: 5132 KLQLSKHKEFQKTLGGK-----------------QPVYDTTIRTGRALKEKT-LLPED-S 5172

Query: 2655 QKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVR 2714
            QK+   +     EV++KW+++   +   Q ++++AL        A+  L   + + E   
Sbjct: 5173 QKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 5228

Query: 2715 NGWKPV-GDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQ 2773
               +PV GDL  D + + ++    F++E+      V+ +     +L       +  +  Q
Sbjct: 5229 AEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQ 5286

Query: 2774 LDDLNMRWKL---LQVSVDDRLKQ 2794
            L +L+ RW     L VS   RL+Q
Sbjct: 5287 LQELSTRWDTVCKLSVSKQSRLEQ 5310



 Score =  259 bits (661), Expect = 4e-68
 Identities = 495/2577 (19%), Positives = 1012/2577 (39%), Gaps = 263/2577 (10%)

Query: 230  PEDVAVQLPDKKSIIMYLTSL-FEVLPQQVTIDAIREV---ETLPRKYKKECEEEAINIQ 285
            PE V  QL +   I   L  L  EV   Q   D +  +   + L  + KK  E  A+ +Q
Sbjct: 3156 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQ 3215

Query: 286  STAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEV 345
                       R +     T+       +Q   +E+ TWL   +    +   IS  +E +
Sbjct: 3216 GLEDLAADRINRLQAALASTQ------QFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            + Q   +E F   L  H  S   ++  G  L+       EE+  +Q Q+  L   WE L 
Sbjct: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-VPPGEEKRTLQNQLVELKNHWEELS 3328

Query: 406  VESMDRQSRLHDVLMELQKKQ--LQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEH 463
             ++ DRQSRL D + + QK Q  ++ L  W+   E+   KM    +  D   L+  L   
Sbjct: 3329 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWI---EDCKAKMSELRVTLDPVQLESSLLRS 3385

Query: 464  KSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNR 523
            K++ +++E  +  +  L     I+  NS E+    + D+   + +   AV    + +   
Sbjct: 3386 KAMLNEVEKRRSLLEILNSAADILI-NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS 3444

Query: 524  LQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMK 583
            L+E+    Q L E Q   K    + E A         K Q E+  ++   A   +++E  
Sbjct: 3445 LEEMT---QRLREFQESFKNIEKKVEGA---------KHQLEIFDALGSQACSNKNLEKL 3492

Query: 584  RQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLG 643
            R   + L  +   V  L                 TQ    LV+   D S+    A   L 
Sbjct: 3493 RAQQEVLQALEPQVDYL--------------RNFTQ---GLVEDAPDGSD----ASQLLH 3531

Query: 644  MSQIPQKDLLETV-RVREQAITKKSKQELPPPPPPKKRQIHVDI-EAKKKFDAISAELLN 701
             +++ Q++ LE   RV    +  ++K E       + R++   + +   + D + A    
Sbjct: 3532 QAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA---- 3587

Query: 702  WILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTG-QILVEQMG 760
             I +   ++Q+      + +     +K  ++A E E R  +     L+  G +  +E + 
Sbjct: 3588 -IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3646

Query: 761  KE-GLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEE 819
            K+ G  TE  K   E++      V    ED  RK++   D     ++ + L+ V+ T+ E
Sbjct: 3647 KQCGKLTERGKARQEQLELTLGRV----EDFYRKLKGLNDATTAAEEAEALQWVVGTEVE 3702

Query: 820  WVKHTSISESSRQSLPSLKDSCQRELTNLLGL-HPKIEMARASCSALMSQPSAPDFVQRG 878
             +          Q      D  Q +L  + GL    I+ A   C            ++  
Sbjct: 3703 IINQQLADFKMFQK--EQVDPLQMKLQQVNGLGQGLIQSAGKDCDV--------QGLEHD 3752

Query: 879  FDSFLGRYQAVQEAVEDRQQHLENELKGQPGHA--YLETLKTLKDVLNDSENKAQVSLNV 936
             +    R+  + + V  R   L+  L     H   + + L+ L   L D+E         
Sbjct: 3753 MEEINARWNTLNKKVAQRIAQLQEALL----HCGKFQDALEPLLSWLADTEELIANQKPP 3808

Query: 937  LNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQG 995
              +   V+  +QE+K L  +L+++K  +  L  E   + ++    D EK+  Q  + ++ 
Sbjct: 3809 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ-LESLES 3867

Query: 996  KWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQ 1055
            +W +L    +     LE+I +  + F   +  I  ++   +  L   +      A +Q+Q
Sbjct: 3868 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3927

Query: 1056 LDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIAT 1115
            + +  A   +IE   + +    +I  +L S      +  +  ++   Q +  ++      
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987

Query: 1116 QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDV 1175
            + + L ++   A    +D  E+  W+ + E++      +    + L     +     E++
Sbjct: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047

Query: 1176 LQKEVRV-KILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSC 1234
            + ++  V + +K+   LL          +  +L+ +   Y  +         TLE+    
Sbjct: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRT---QIR 1291
              +     +  T WL  +EE + ++       + + +  +  + + +   ++R     + 
Sbjct: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 4167

Query: 1292 ELGQTLID------GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQM 1345
            E+ + L++         LD ++S+     N +Y+ +S     +   ++  +Q  ++ +Q 
Sbjct: 4168 EVSRALLELVPWRAREGLDKLVSDA----NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223

Query: 1346 LQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQA---EISAHELTLEELRRNMRSQP 1402
                   + E  ++L      R++  Q   + Q  +A   +I  H+ +++EL  +     
Sbjct: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS--- 4280

Query: 1403 LTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVL----------- 1451
                E     G  Q  VLQ K   +  +++      +     L+  +VL           
Sbjct: 4281 ----EIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336

Query: 1452 ----DGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQ 1507
                +  +A +  L    +D + ++   ++  +L ++++E K  ++ ++K G  + ++  
Sbjct: 4337 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL-KELN 4395

Query: 1508 TDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETEL 1567
             +  + ++E+    + +Y  +  +V +    L+ A   + ++ +    +   L   E   
Sbjct: 4396 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 4455

Query: 1568 VQKSTSEGLLGDLDTE---ISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPIL-- 1622
             +      +  ++D     IS  K+   +LEK +     +      L    +G++  L  
Sbjct: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA 4515

Query: 1623 ---EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIE 1679
               +++L  +   W  ++   E+     ++     E F  ++A + T +   + ++ ++E
Sbjct: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLE 4575

Query: 1680 KKPTS-----KQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELN 1734
                      +Q E  + +  E D  + ++E +R     L+ A G + +  V   + E+N
Sbjct: 4576 SPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMN 4635

Query: 1735 RNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETF-----ETGVPFSDLEKLENDIENMLK 1787
              +E +++  K    KL  A +   Q   T +        T +    +  +  D+  +  
Sbjct: 4636 NAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD 4695

Query: 1788 FVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLL-LLHTRYNKI 1846
             + +  E   E   + ++  ++E++  +GE ML +  ++  ++ IR  L  L H   N  
Sbjct: 4696 QLNEMKEFKVE---VYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4752

Query: 1847 KAIPIQQRKM-------GQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAI 1899
            + I  +Q K+       GQ    +   +    +L    ++L     +     V E+  A 
Sbjct: 4753 EKIAHRQHKLEGALLALGQFQHALEELM---SWLTHTEELLDAQRPISGDPKVIEVELA- 4808

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAV--IHEKQPDVILEASGPEAIQIRDTLTQLNAKW 1957
                  +   LKN     D L  Q  V  +++   +++  ++G +A  +R  L  +N  W
Sbjct: 4809 ------KHHVLKN-----DVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4857

Query: 1958 DRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIH 2017
            + + +   +R+      +++ + FH ++ D    +T  E  L  +   GG  +  + ++ 
Sbjct: 4858 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4917

Query: 2018 -QQELEVGISSHQPSFAALNRTGDGIVQKLSQAD---GSFLKEKLAGLNQRWDAIVAEVK 2073
               EL   + + + ++  L     G +  LS+ D   GS  ++ +A L Q+W  + ++++
Sbjct: 4918 THMELYSQLKAKEETYNQL--LDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975

Query: 2074 DRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGEN-----LQELRDLTQE 2128
            +R+ +L+       ++++ L E I WLT AE ++   S   L  N     ++E +    E
Sbjct: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANE 5035

Query: 2129 MEVHAEKLKWLNRT--ELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECI 2186
            +  H +++  L++T  +L+ LS K     +   I   L +V   W K+       ++  I
Sbjct: 5036 VNAHRDQIIELDQTGNQLKFLSQKQ----DVVLIKNLLVSVQSRWEKV-------VQRSI 5084

Query: 2187 QEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLID 2246
            +   S+   R  A                  Q H   +            +L DWL   +
Sbjct: 5085 ERGRSLDDARKRAK-----------------QFHEAWK------------KLIDWLEDAE 5115

Query: 2247 QMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAI 2306
              L S +    D ++I   +S+ K  +  L  + P  D      + LK K    +    +
Sbjct: 5116 SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKL 5175

Query: 2307 TEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQAR 2366
               L  V+++WD        RQ +LE+ ++ S Q+ D  +   + + K E +L   Q   
Sbjct: 5176 DNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVH 5235

Query: 2367 RD-PLTKQISD-NQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW 2424
             D  L   + D +++  +ELG   G V       ++L+E    DDT  VK   + L T W
Sbjct: 5236 GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRW 5294

Query: 2425 INLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSIL 2484
              + +    +Q+ LE   +  +  R  +   L+W+ EAE T+           AL D   
Sbjct: 5295 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRF-------RGALPDDTE 5347

Query: 2485 ARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEA---------TMLQHRLDD 2535
            A         +Q+ ID H +  K ++  R  +  A+   E           T ++H +  
Sbjct: 5348 A---------LQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITI 5398

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEEL--KKQMPIGGDVP 2593
            +  R+ ++   +   +  LE +  +       LEEL+ W+   +  L  + Q PI  ++ 
Sbjct: 5399 IRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNID 5458

Query: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPE-EPRRNLQSKTELTPEE 2652
             ++      +    E+  K+  V + V +       +P  AP  E  R+   K+   P  
Sbjct: 5459 RVKALIAEHQTFMEEMTRKQPDV-DRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTP 5517

Query: 2653 RAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE 2709
                I        S+ + K   +N +++ WQ+    ALE+ R L  A+D L+ ++KE
Sbjct: 5518 PPMPIL-------SQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-ELKE 5566



 Score =  239 bits (609), Expect = 4e-62
 Identities = 461/2591 (17%), Positives = 1053/2591 (40%), Gaps = 307/2591 (11%)

Query: 321  VLTWLLSAEDTFQEQDDISDDV--EEVKDQFATHEAFMMELTAHQSSVGSVLQA-GNQLI 377
            VL WL S E+  +  D +S     E VK Q  +++AF+ EL  +   +  V +A    L+
Sbjct: 2912 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLV 2971

Query: 378  TQGTLSDEEEFE-IQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQL--QQLSAWL 434
            T     + E ++ IQE+   LN+RWE     ++ RQ +L +    L   Q    QL  WL
Sbjct: 2972 TYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 3028

Query: 435  TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV--VIVDENSG 492
               E  +  +    +D ++ + QK  ++ + +  + EA + +   L      ++      
Sbjct: 3029 MEKELMMGVLGPLSIDPNMLNAQK--QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086

Query: 493  ESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL---WQELLEE----------QC 539
              +T+ ++ +LQ + ++W  +      R +++ +  +    +QELL++          + 
Sbjct: 3087 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 3146

Query: 540  LLKAWLTEKEEALNKV--QTSNFKDQ--------KELSVSVRRLAILKEDMEMKRQTLDQ 589
             +++ ++ + EA+ +   +TS  +          KE       L++L  +  +K +   +
Sbjct: 3147 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 3206

Query: 590  LSEIGQDVGQLLDNSKASKKIN------SDSEELTQRWDSLVQRLEDSSNQ--------- 634
            L  +   +  L D   A+ +IN      + +++  Q +D L   L+D  +Q         
Sbjct: 3207 LETVALPLQGLED--LAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 3264

Query: 635  -VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVD-IEAKKKF 692
             + +  ++L  ++  QK L +     E  + +     L  PP  +KR +    +E K  +
Sbjct: 3265 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHW 3324

Query: 693  DAISAELLNWILKWKTAIQTTE-------------------IKEYMKMQDTSEMKKKL-- 731
            + +S +  +   + K  +Q  +                   + E     D  +++  L  
Sbjct: 3325 EELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLR 3384

Query: 732  -KALEKEQRERIPRADELNQTGQILVE--QMGKEGLPTEE--IKNVLEKVSSEWKNVSQH 786
             KA+  E  +R    + LN    IL+   +  ++G+  E+  I   ++ V+ E +  +  
Sbjct: 3385 SKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS 3444

Query: 787  LEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELT 846
            LE++ ++++   +    FK +++  +  K + E          S ++L  L+   Q+E+ 
Sbjct: 3445 LEEMTQRLR---EFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR--AQQEV- 3498

Query: 847  NLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAV---QEAVEDRQQ----- 898
             L  L P+++  R     L+    APD    G D+    +QA    QE +E +Q+     
Sbjct: 3499 -LQALEPQVDYLRNFTQGLVED--APD----GSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551

Query: 899  -HLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA---LQEKKT 952
              +EN+L+G  Q      E    L D+ ++ +    +  +  +  +++E     L +   
Sbjct: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611

Query: 953  LDEILENQKPALHKLAEETKALEK-NVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHL- 1010
            L   +E  +     + EE   L+   +  ++E L KQ      GK  +      + L L 
Sbjct: 3612 LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ-----CGKLTERGKARQEQLELT 3666

Query: 1011 ---LEEIALTLRAFEADSTVIEK-----WMDGVKDFLMKQQAAQGDDAGLQR-QLDQCSA 1061
               +E+    L+     +T  E+     W+ G +  ++ QQ A  D    Q+ Q+D    
Sbjct: 3667 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA--DFKMFQKEQVDPLQM 3724

Query: 1062 FVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS 1121
             + ++  +   L     I++  +   V G++  ++    +   +   L+K++A + ++L 
Sbjct: 3725 KLQQVNGLGQGL-----IQSAGKDCDVQGLEHDME----EINARWNTLNKKVAQRIAQLQ 3775

Query: 1122 ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVR 1181
            E+       +  L  +  W+   EE    +       + +++ ++E K  +  +  ++  
Sbjct: 3776 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3835

Query: 1182 VKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLH 1240
            V +L+     +A       +E +T +L  +   +  L ++   +   LE++     +   
Sbjct: 3836 VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3895

Query: 1241 YLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL---ESLESVLRHPADNRTQIRELGQTL 1297
              +  + +L+  E+++ ++E +  +T  + + +   ++LE  + + A +  Q  ++GQ+L
Sbjct: 3896 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955

Query: 1298 --IDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGE 1355
              +       ++SEK+++  +RY ++      K   L++ L   R             GE
Sbjct: 3956 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR-----------LFGE 4004

Query: 1356 LDKQLTTYLT---DRIDAFQVPQEAQKIQAEISAHELTLEEL---RRNMRSQPLTSPESR 1409
             + ++  +L    D++ +  V    Q +     A  L L E    R+    Q + + ++ 
Sbjct: 4005 DEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL 4064

Query: 1410 TARG-GSQMDVLQRKLREVSTKF---------------QLFQKPANFEQRMLDCKRVLDG 1453
              +  G ++ ++Q KL  + T++               Q  Q    F+    +    L  
Sbjct: 4065 LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLRE 4124

Query: 1454 VKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKG 1513
            V+ EL     +    + I     +  +L K + E +L ++TV +  R +++       +G
Sbjct: 4125 VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREG 4184

Query: 1514 MDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTS 1573
            +D+ ++     Y  +   + +   +++ A Q +++ ++ A +   W++ T+ +L+     
Sbjct: 4185 LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI 4244

Query: 1574 EGLLGDLDTEISWAKNVLKDLEKRKADLNTI-TESSAALQNLIEGSEPILEERLCVLNAG 1632
                     ++   K    D+ + K  ++ + +  S       E  + +L+E+   L   
Sbjct: 4245 RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQ 4304

Query: 1633 WSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDE-----IEKKPTSKQE 1687
            +  +     +    L   Q  +  F      +S W+ +  AL+ +     I+ +   +Q+
Sbjct: 4305 YEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQ 4364

Query: 1688 EIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSA 1747
            E +++L   + +    ++ +      L         E+VE K  +    + ++ + ++  
Sbjct: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG-EMVEEKYQKAENMYAQIKEEVRQR 4423

Query: 1748 KLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN-------------DIENMLKFVEKHLE 1794
             L +  E + Q    TE  +   P   LE LEN             +++ + + +  +  
Sbjct: 4424 ALAL-DEAVSQSTQITEFHDKIEPM--LETLENLSSRLRMPPLIPAEVDKIRECISDNKS 4480

Query: 1795 SSDEDEKMDEESAQIEEVLQRGEEMLHQPM---EDNKKEKIRLQLLLLHTRYNKIKAIPI 1851
            ++ E EK+       E + +RGEE++ +     +D   ++I+ +L  +   +  IKA   
Sbjct: 4481 ATVELEKLQPS---FEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA-RA 4536

Query: 1852 QQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLK 1911
            ++R++  L     +     D    +  I    D V   L  P ++ +I +    Q ++ +
Sbjct: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH-DLESPGIDPSIIKQ---QVEAAE 4592

Query: 1912 NIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCF 1971
             IK++ D L E++  I     D+I      E  ++R ++ ++N  W+ +N+ + +R    
Sbjct: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652

Query: 1972 DRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQ-QELEVGISSHQP 2030
            + AM+   Q+   L  +  W+      L      G  L+  K ++++ +E +V +   Q 
Sbjct: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4712

Query: 2031 SFAALNRTGDGIVQKLS-QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKY 2089
                LN  G+ +++K + + D   ++E L  L   W+ +  ++  RQ +L+G    + ++
Sbjct: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772

Query: 2090 RHQLDEIICWLTKAEHAMQKRSTTE-----LGENLQELRDLTQEMEVHAEKLKWLNRTEL 2144
            +H L+E++ WLT  E  +  +         +   L +   L  ++  H   ++ +N+   
Sbjct: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832

Query: 2145 EMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQ 2204
            E+L  +S +  +   +   L  +N  W  + ++     +E  Q+  S  Q     H  ++
Sbjct: 4833 ELL--ESSAGDDASSLRSRLEAMNQCWESVLQKT----EEREQQLQSTLQQAQGFHSEIE 4886

Query: 2205 KVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINK 2264
              +L  +  +  + + + +       L +T  E  D  + +   LK+        E  N+
Sbjct: 4887 DFLLELTRMESQLSASKPT-----GGLPETAREQLDTHMELYSQLKAK------EETYNQ 4935

Query: 2265 TVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGV 2324
             + + ++                 L+++     S ++   A+ E+      +W      +
Sbjct: 4936 LLDKGRL---------------MLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKM 4974

Query: 2325 ELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQ 2382
            E R+ +LE+ +  + ++ +  +E    +   E  L I        + +  QI ++++   
Sbjct: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034

Query: 2383 ELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEW 2442
            E+      ++  D    +L       D   +K     +++ W  + Q   +R  +L+   
Sbjct: 5035 EVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 5094

Query: 2443 RTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAH 2502
            +  +      +  + W+++AE         SH ++ L       E+      I+ ++  H
Sbjct: 5095 KRAKQFHEAWKKLIDWLEDAE---------SHLDSEL-------EISNDPDKIKLQLSKH 5138

Query: 2503 NDIFKSIDGNRQ------KMVKALGNS----EEATMLQHRLDDMNQRWNDLKAKSASIRA 2552
             +  K++ G +       +  +AL       E++  L + L ++  +W+ +  KS   + 
Sbjct: 5139 KEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQH 5198

Query: 2553 HLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEK 2612
             LE +     + + +L+ L+ WL   + +L +  P+ GD+  +    D  K  ++EL ++
Sbjct: 5199 KLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKR 5258

Query: 2613 EYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKW 2672
              +V       R  +                        E ++     ++ Q  E+  +W
Sbjct: 5259 TGTVQVLKRSGRELI------------------------ENSRDDTTWVKGQLQELSTRW 5294

Query: 2673 ESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVR--NGWKPVGDLLIDSLQD 2730
            +++  ++ + Q ++++AL++    +  +  L   + EAE      G  P     + SL D
Sbjct: 5295 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 5354

Query: 2731 HIEKIMAFREE 2741
              ++ M   EE
Sbjct: 5355 THKEFMKKVEE 5365



 Score =  231 bits (590), Expect = 7e-60
 Identities = 478/2686 (17%), Positives = 1048/2686 (39%), Gaps = 312/2686 (11%)

Query: 314  YQIALEEVLTWLLSAEDTFQE--QDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQ 371
            +Q + + +  W+ + E   ++   D ++ D   +++Q AT +    EL  HQ  V  + +
Sbjct: 2439 FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQK 2498

Query: 372  AGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQ--LQQ 429
                ++        +   +QE    + + +++L     +R S L   + + Q  Q  L+ 
Sbjct: 2499 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2558

Query: 430  LSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE 489
            L   +   E+ ++  +   L   V  +Q+ L  +  L+ D+  ++  + +   MV    E
Sbjct: 2559 LLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFME 2616

Query: 490  NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
             +  +  A+L+ +L ++ +R+  +C   +E+ + L+++ +   E+ E    L   L +  
Sbjct: 2617 TADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL-LPQAEMFEH---LSGKLQQFM 2672

Query: 550  EALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV---GQLLDNSKA 606
            E  +++  S  +  ++++   +++  L  +ME +++ LD L  +  ++   G  LD  + 
Sbjct: 2673 ENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQH 2732

Query: 607  SKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKK 666
              ++ +  ++ T+   ++ +R +D+S+   Q      + +  QK L ET        T  
Sbjct: 2733 QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792

Query: 667  SKQELPPPPPPKKRQIHVDIEAK----KKFDAISAELLNWILK----------------- 705
            S +EL       K  +  D  +K    ++ +     L N I++                 
Sbjct: 2793 SAKELEKQIEHLKSLLD-DWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2851

Query: 706  ---------WKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP----RADELNQTG 752
                     + T    TEI+    M D +   +KL  +  E++E +     R +E+++  
Sbjct: 2852 GSSVGSVNGYHTCKDLTEIQ--CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909

Query: 753  QILVEQMGKEGLPTEEIKNVLEKVSSEWKNVS------------QHLEDLERKIQLQEDI 800
              +++ +  +    EE+   ++ +SS  K  +              LE    KIQ  ++ 
Sbjct: 2910 NSVLQWLESK----EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA 2965

Query: 801  NA----YFKQLDELEKVIKTKEE----WVKHTSISESSRQSLPSLKD--SC-QRELTNLL 849
             A     +    E E   K +EE    W + T ++ + ++ L       +C Q   + L 
Sbjct: 2966 LAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR 3025

Query: 850  GLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPG 909
                + E+       L   P+  +  ++     L  ++A ++  E   +  +  L G PG
Sbjct: 3026 PWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG-PG 3084

Query: 910  HAYLETLKTLKDV---------LNDSENKAQVSLN-----------VLNDLAKVEKALQE 949
               L T +  K++         L D  N     ++           +L DL++  +A+ +
Sbjct: 3085 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144

Query: 950  KKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDL- 1008
            + ++   +  Q  A+ +  EET      +  D+E+L   E  + Q   ++L VL+ +   
Sbjct: 3145 RLSVQSAISTQPEAVKQQLEETS----EIRSDLEQL-DHEVKEAQTLCDELSVLIGEQYL 3199

Query: 1009 -----HLLEEIALTLRAFE--------------ADSTVIEKWMDGVKDFLMKQQAAQGDD 1049
                   LE +AL L+  E              A +   ++  D ++ +L  +Q+ Q  +
Sbjct: 3200 KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKN 3259

Query: 1050 AGLQRQLDQCSAFVNEIETIESSLKN--------MKEIETNLRSGPVAGIKTWVQTRLGD 1101
              +  +L++  + + E E  + SL          + E E+ L S P    K  +Q +L +
Sbjct: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319

Query: 1102 YQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEEL 1161
             +   E+LSK+ A ++SRL +  +KA   +  + ++  W+   + +  E       P +L
Sbjct: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-DPVQL 3378

Query: 1162 ESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRI 1221
            ES++   K    +V ++   ++IL     +L     +    +  E   + +N   +   +
Sbjct: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 3438

Query: 1222 RGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVN---------EA 1272
            + K  +LEE+           + + ++ N +E++++  +   E  DA+          E 
Sbjct: 3439 QAKTGSLEEMTQ------RLREFQESFKN-IEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491

Query: 1273 LESLESVLRHPADNRTQIRELGQTLI----DGGILDDIISEKLEAFNSRYEDLSHLAESK 1328
            L + + VL+        +R   Q L+    DG     ++ +  E     + ++     S 
Sbjct: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA-EVAQQEFLEVKQRVNSG 3550

Query: 1329 QISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHE 1388
             + +E +L+ + +    ++ +   L +LD +L     D + A  + ++   +Q++I    
Sbjct: 3551 CVMMENKLEGIGQFHCRVREMFSQLADLDDEL-----DGMGA--IGRDTDSLQSQIEDVR 3603

Query: 1389 LTLEE---LRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRML 1445
            L L +   L+ ++ +            G   +  L+R+L  ++ +     +     Q  L
Sbjct: 3604 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3663

Query: 1446 --------DCKRVLDGVK------AELHVLD-VKDVDPDVIQTHL-DKCMKLYKTLSEVK 1489
                    D  R L G+        E   L  V   + ++I   L D  M   + +  ++
Sbjct: 3664 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQ 3723

Query: 1490 LEVETVIKTGRHIVQKQQTD-NPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK 1548
            ++++ V   G+ ++Q    D + +G++  +  +   +N L  +V +    L+ A     K
Sbjct: 3724 MKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGK 3783

Query: 1549 MKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESS 1608
             +     L  WL+ TE  +  +         +  +I   K + + L+ RKA ++ +    
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843

Query: 1609 AALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI-------FDGNV 1661
              +    E     L +R  +     S    WTE   +     Q QLE        F    
Sbjct: 3844 GRIAQSAE-----LADREKITGQLESLESRWTE-LLSKAAARQKQLEDILVLAKQFHETA 3897

Query: 1662 AHISTWLYQAEALLDEIEKKPTSK---QEEIV--KRLVSELDDANLQVENVRDQALILMN 1716
              IS +L   E  L   E   T     Q++I+  K L  ++++    V         L +
Sbjct: 3898 EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSS 3957

Query: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLE 1776
                + + ++  K+  L   + ++         L+ Q      L   +  E     +++E
Sbjct: 3958 LTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017

Query: 1777 -KLENDIENMLKFVEKHLESSDE---DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKI 1832
             KL +      K    H + +D    +E++      +++ ++ G+ +L Q   +      
Sbjct: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE------ 4071

Query: 1833 RLQLLLLHTRYNKIKA----IPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVEL 1888
              ++LL+  + + IK     I +   K  +     R   L T +     ++   + +VE 
Sbjct: 4072 --EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ--LATKFQSTYEELTGWLREVEE 4127

Query: 1889 SLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948
             L      +   E     +   K +K ++ +    +  ++E     +LE     A +  D
Sbjct: 4128 ELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR-ALLELVPWRAREGLD 4186

Query: 1949 TL-TQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGG 2007
             L +  N ++  ++     R    D A++  +Q+    +    W+ E +  L+       
Sbjct: 4187 KLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRL 4246

Query: 2008 SLDLEKARIH-QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWD 2066
              D   A++  Q+   + I  H+ S   L      I     +   + L+EK   L Q+++
Sbjct: 4247 EQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306

Query: 2067 AIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-----ELGENLQE 2121
            AI     +R  RL+     V ++    +E+  W+ +    + +  +      +L +  +E
Sbjct: 4307 AISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366

Query: 2122 LRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREV--- 2178
            +R L + +  H   +  L +   ++   K L+  E + + E  +     + +I  EV   
Sbjct: 4367 MRQLRESIAEHKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQR 4423

Query: 2179 PTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITEL 2238
               L E + + + +++      P ++ +  +SS   +P          IPA++DK     
Sbjct: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL--------IPAEVDK----- 4470

Query: 2239 ADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                                   I + +S  K    +LE+  P  + +    + L  ++ 
Sbjct: 4471 -----------------------IRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507

Query: 2299 SSDMRTA---ITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355
             +D   A   I +KL+++   W+  +   E R+ +  D++  + ++          ++  
Sbjct: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567

Query: 2356 EARLYILQQARRDP-LTKQISDNQILLQELGPGDGIVMAFDNVL-QKLLEEYGSDDTRNV 2413
            +  ++ L+    DP + KQ  +    ++E   G    + F  +L   L+   G  +   V
Sbjct: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4627

Query: 2414 KETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDAS 2473
            +++ + +  +W NL ++  +R   LE   +     +  L+    W+      +  +    
Sbjct: 4628 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG 4687

Query: 2474 HRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRL 2533
               N ++D +       +M++ + E+       + ++   + M+K   +  +  +++  L
Sbjct: 4688 TDLNTVKDQL------NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPL 4741

Query: 2534 DDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVP 2593
             ++   W +L  K A  +  LE +     +   +LEEL+ WL   +E L  Q PI GD  
Sbjct: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801

Query: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEER 2653
             ++++      L+ ++   + +V          L                       E  
Sbjct: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELL-----------------------ESS 4838

Query: 2654 AQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESV 2713
            A   A ++R +   + + WES+   T   ++Q+   L++ +     ++D   ++   ES 
Sbjct: 4839 AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQ 4898

Query: 2714 RNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-----LSPLDLHPSL 2768
             +  KP G L     +   E++    E  + +  K +T N L  +     LS  D     
Sbjct: 4899 LSASKPTGGL----PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4954

Query: 2769 KMSRQLDDLNMRWKLLQVSVDDRLKQLQEA---HRDFGPSSQHFLS 2811
            K  + +  L  +W ++   +++R  +L+EA     +F  S Q F++
Sbjct: 4955 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 5000



 Score =  191 bits (484), Expect = 1e-47
 Identities = 475/2630 (18%), Positives = 1038/2630 (39%), Gaps = 322/2630 (12%)

Query: 333  QEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQE 392
            Q+ +D+   + E K Q     AF ++    + +     Q   Q++    L +E +   Q+
Sbjct: 1964 QQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNRQMLR---LLNELQRSFQD 2019

Query: 393  QMTLLNARWEALR--VESMDRQSRLHDVLMELQKKQ------LQQLSAWLTLTEERIQKM 444
             +    A+ +AL+  ++ M++++    ++  LQK+Q      L+ L +W+   E  +   
Sbjct: 2020 ILEQTAAQVDALQGHLQQMEQEA----LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGH 2075

Query: 445  ETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQ 504
            +      D+ +LQK   + K LQ D++      N  T    +V +  G      +E+   
Sbjct: 2076 QGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSFATVVKDIEG-----FMEENQT 2124

Query: 505  KLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQK 564
            KL  R     R       +L +    ++ L EE  + +  L E   +  + +T   K  K
Sbjct: 2125 KLSPRELTALR------EKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAK 2178

Query: 565  ELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKK--------------- 609
            EL+ + +++  L          LD ++ +G   GQLL N    ++               
Sbjct: 2179 ELAENKKKIDAL----------LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTD 2228

Query: 610  ----INSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITK 665
                +N   E+L ++ + +  R ++  +Q    +     +Q         +   EQ + +
Sbjct: 2229 GYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ 2288

Query: 666  KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS 725
            +   EL         Q   +++  +       + L    ++++ ++ +E KE   M    
Sbjct: 2289 QKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE-KELENMHKGG 2347

Query: 726  EMKKKLKALEKEQ----RERIPRADEL---NQTGQ--ILVEQMGKEGLPTEEIKNVLEKV 776
               + L +L K Q     + I    +L     +GQ  + +E   KEG    EI N+   V
Sbjct: 2348 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL---V 2404

Query: 777  SSEWKNVSQHLEDLERK-IQLQEDINAYFKQLDELEKVIKTKEEWVK--HTSISESSRQS 833
              + K+ ++    L  K  +L   +N    Q  + +    + + W++    ++ +    +
Sbjct: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDT 2464

Query: 834  LPSLKDSCQRELTNLLGLH----------PKIEMARASCSALMSQPSAPD--FVQRGFDS 881
            + S     Q +L     L            K++        +  +P APD   VQ   DS
Sbjct: 2465 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP-APDHRHVQETTDS 2523

Query: 882  FLGRYQAVQEAVEDRQQHLENEL-KGQPGHAYLET-LKTLKDVLNDSENKAQVSLNVLND 939
             L  +Q++  ++ +R   L+  + + Q     LE+ L+++ +V  + E K   SL+    
Sbjct: 2524 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLS---- 2579

Query: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
               +++AL     L + +  QK +L    E      +        + + +  +V  ++ +
Sbjct: 2580 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2639

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L +   +    L+++      FE  S  ++++M+     L        D     +Q+ + 
Sbjct: 2640 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2699

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
            +    E+E  + +L  ++ + T L S   A      Q R+ + +    +L K +  ++  
Sbjct: 2700 NL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD 2756

Query: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKED----- 1174
             S  QE+    +K +   Q+W+ + E      +    S +ELE  +E +K   +D     
Sbjct: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIEHLKSLLDDWASKG 2815

Query: 1175 VLQKEVRVK--ILKDNIKLLAAK---------VPSGGQELTS-----------ELNVVLE 1212
             L +E+  K   L++ I  + A          +PS G  + S           E+   + 
Sbjct: 2816 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS 2875

Query: 1213 NYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETT----WLNTLEERMKSTEVL--PEKT 1266
            +  L   ++ G  H  +E     +  +  +  E      WL + EE +KS + +  P KT
Sbjct: 2876 DVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT 2935

Query: 1267 DAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEK--------LEAFNSRY 1318
            + V    ES ++ L     N  +I+++ + L   G+L    + +         E  NSR+
Sbjct: 2936 ETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAENWKKIQEELNSRW 2993

Query: 1319 EDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQ 1378
            E  + +  ++Q  LE+    L         L+  L E +  +       ID   +  + Q
Sbjct: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053

Query: 1379 KIQAEISAHELTLEELRR-NMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKF------ 1431
            ++Q  +   E   ++  + N  +Q + +     +   SQ   +Q++L+ ++ K+      
Sbjct: 3054 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ---VQKELQSINQKWVELTDK 3110

Query: 1432 ---------QLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLY 1482
                     Q   K   +++ + D    +  V   L V       P+ ++  L++  ++ 
Sbjct: 3111 LNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR 3170

Query: 1483 KTLSEVKLEV---ETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDL 1539
              L ++  EV   +T+      ++ +Q   +   + ++L ++ +    L     +    L
Sbjct: 3171 SDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE--LKKRLETVALPLQGLEDLAADRINRL 3228

Query: 1540 ERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKA 1599
            + A    ++ ++    L  WL   +++  +       L  L +++   +   K L +   
Sbjct: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSG 3288

Query: 1600 DLNTI-TESSAALQNLIEGSEP-ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIF 1657
                I  E  + L ++  G E   L+ +L  L   W  +   T D  + L +   + + +
Sbjct: 3289 SYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 3348

Query: 1658 DGNVAHISTWLYQAEALLDE--IEKKPTSKQEEIV--KRLVSELDDANLQVENVRDQALI 1713
              +V  +  W+   +A + E  +   P   +  ++  K +++E++     +E +   A I
Sbjct: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 3408

Query: 1714 LMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFS 1773
            L+N+   +  + +  + A +N+N + V++ ++ AK    +E      +T    E    F 
Sbjct: 3409 LINS-SEADEDGIRDEKAGINQNMDAVTEELQ-AKTGSLEE------MTQRLREFQESFK 3460

Query: 1774 DLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLH------QPMEDN 1827
            ++EK     ++ L+  +     +  ++ +++  AQ +EVLQ  E  +       Q + ++
Sbjct: 3461 NIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQ-QEVLQALEPQVDYLRNFTQGLVED 3519

Query: 1828 KKEKIRLQLLLLHTRYNKIKAIPIQQR------KMGQLASGIRSSLLPTDYLVEINKILL 1881
              +      LL      + + + ++QR       M     GI        +   + ++  
Sbjct: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI------GQFHCRVREMFS 3573

Query: 1882 CMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV--ILEAS 1939
             + D++  L   +   AI  D    +  +++++  L+K+      I   + +   +LE  
Sbjct: 3574 QLADLDDEL---DGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEE 3630

Query: 1940 GP-EAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
            G  + + ++  L  LN +  ++      R+   +  +     F+  L  L    T AEE 
Sbjct: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3690

Query: 1999 LVDTCAPGGSLDLEKARIHQQEL--EVGISSHQPSFAALNRTGDGIVQKLSQ-ADGSFLK 2055
                   G  +++   ++   ++  +  +   Q     +N  G G++Q   +  D   L+
Sbjct: 3691 EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3750

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEH--AMQKRSTT 2113
              +  +N RW+ +  +V  R  +L+       K++  L+ ++ WL   E   A QK  + 
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810

Query: 2114 E---LGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMT 2170
            E   +   +QE + L + ++     +  L      +   +S  L +R+KI+  L ++   
Sbjct: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIA--QSAELADREKITGQLESLESR 3868

Query: 2171 WNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPAD 2230
            W ++                    ++ AA     + +LV     +  Q H T+E      
Sbjct: 3869 WTELL-------------------SKAAARQKQLEDILV-----LAKQFHETAE------ 3898

Query: 2231 LDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLA 2290
                   ++D+L + ++ L ++        +I + + R K  + D+E     +     + 
Sbjct: 3899 ------PISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIG 3952

Query: 2291 QNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEE 2350
            Q+L +  S ++ +  ++EK++ ++ ++   Q     +   L+  + ++  + +   E   
Sbjct: 3953 QSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN 4011

Query: 2351 LMRKYEARL--YILQQARRDPLTKQISDNQILLQEL-GPGDGIVMAFDNVLQKLLEEYGS 2407
             + + E +L    ++  ++D L +Q +D+  L +E+      +  A  N  Q LL++   
Sbjct: 4012 WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNG-QALLKQTTG 4070

Query: 2408 DDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVN 2467
            ++   ++E  + +KT + ++  + +     LE   +     +   E    W++E E  + 
Sbjct: 4071 EEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130

Query: 2468 VLVDASHR-ENALQDSILARELKQQMQDIQAEIDAHNDIFKSI-----DGNRQKMVKALG 2521
                 S   E   Q     +ELK+++ + +  +D  N++ +++        R+ + K + 
Sbjct: 4131 TSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190

Query: 2522 NSEEATMLQHRL--DDMNQRWNDLKAKSASIRAHLEAS------AEKWNRLLMSLEELIK 2573
            ++ E    Q++L  D + QR +++ A     + + +A+        +  R LM+L  +  
Sbjct: 4191 DANE----QYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRL 4246

Query: 2574 WLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE------------LKEK--------- 2612
              +    +L+ Q     D+   +   D   + R E            L+EK         
Sbjct: 4247 EQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306

Query: 2613 EYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKA-----MRKQSSE 2667
              S+LN+   AR+  A   +    E    L    E T    AQ  + A     +R+Q  E
Sbjct: 4307 AISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366

Query: 2668 VKEKWESLNAVTSNWQK--QVDKALEKLRDLQGAM--------DDLDADMKEAESVRNGW 2717
            +++  ES+     +  K  ++   L++L   +G M        +++ A +KE    R   
Sbjct: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQR--- 4423

Query: 2718 KPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPS 2767
                 L +D       +I  F ++I P+   ++T+ +LSS+L    L P+
Sbjct: 4424 ----ALALDEAVSQSTQITEFHDKIEPM---LETLENLSSRLRMPPLIPA 4466



 Score =  171 bits (432), Expect = 1e-41
 Identities = 413/2310 (17%), Positives = 891/2310 (38%), Gaps = 285/2310 (12%)

Query: 428  QQLSAWLTLTEE-RIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVI 486
            ++L ++L+L     ++  +  PL+ ++  LQ LL + K L+ +L+     V+     V  
Sbjct: 1808 EKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQ 1867

Query: 487  VDENSGESATAILEDQLQKLGERWTAVCRWTEERWN----------RLQEINILWQELLE 536
            +  +  +   A L   L+K  +          + WN           +++  +L Q    
Sbjct: 1868 IIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQL 1927

Query: 537  EQCL--LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIG 594
            E  L  L+AW+  K   LN   +++  D   L++ +++   LK+ M  ++  LD L+   
Sbjct: 1928 EGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA--- 1984

Query: 595  QDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL--GMSQIPQKDL 652
             D+ Q   +  A       + ++ +  + L +  +D   Q    V  L   + Q+ Q+ L
Sbjct: 1985 FDI-QFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEAL 2043

Query: 653  LETVRVREQAITKKSK-------QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK 705
            ++T++ ++    ++ +       Q        + R    D+ A +K  +   +L + I  
Sbjct: 2044 VKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 2103

Query: 706  WKTAIQTT--EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEG 763
              T+  T   +I+ +M+   T    ++L AL    RE++ +A                  
Sbjct: 2104 RATSFATVVKDIEGFMEENQTKLSPRELTAL----REKLHQA------------------ 2141

Query: 764  LPTEEIKNVLEKVSSEWKNVSQHLED-LERKIQLQEDINAYFKQLDELEKVIKTKEEWVK 822
                  K   E +  E +   + LE+ +   +Q + + +   K+L E +K I    +WV 
Sbjct: 2142 ------KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWV- 2194

Query: 823  HTSISESSRQSLPSLKDSCQRELTNL-----------LG-------LHPKIEMARASCSA 864
             TS+  S  Q L +L    Q    +L           +G       L  + EM +A    
Sbjct: 2195 -TSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 2253

Query: 865  LMSQPSAPDFVQRGFDSFLGR--YQAVQEAVEDRQQHLENELKGQ------PGHAYLETL 916
            L+SQ        +   +FL +  +    E  +  QQ L  ELK Q         A L+ +
Sbjct: 2254 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKL-GELKEQYSTSLAQSEAELKQV 2312

Query: 917  KTLKD----VLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ-----KPALHK- 966
            +TL+D     L D +           +L  + K     +TL  +L+ Q         HK 
Sbjct: 2313 QTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKG 2372

Query: 967  ------------LAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEI 1014
                        L  E    E     ++  L K +  D   ++  L    ++    L  +
Sbjct: 2373 DLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNML 2432

Query: 1015 ALTLRAFEADSTVIEKWMDGVKDFLMK--QQAAQGDDAGLQRQLDQCSAFVNEIETIESS 1072
                  F+  +  ++ WM   +  + K        D   LQ QL        E+   +  
Sbjct: 2433 LGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVP 2492

Query: 1073 LKNMKEIETNLR--SGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANL 1130
            ++ ++++  ++    G  A     VQ       +  + LS  +A + S L ++  ++ ++
Sbjct: 2493 VEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSV 2552

Query: 1131 KKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNI- 1189
            ++ L  + + + + E+    +     S   ++ A+    + K+D+ +++  ++  ++ + 
Sbjct: 2553 QESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT 2612

Query: 1190 KLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWL 1249
            + +     +    L  +L  V + ++ LC + + K  +L+++     E+  +L  +    
Sbjct: 2613 RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQF 2671

Query: 1250 NTLEERMKSTEVLPEKTDAVN--EALESLESVLRHPADNRTQIRELGQTLIDGGILDDII 1307
               + RM ++   P++ D  +  + ++ L   +    +N   +  L   L   G   D+ 
Sbjct: 2672 MENKSRMLASGNQPDQ-DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2730

Query: 1308 SEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDR 1367
              +    N R +D + L ++           ++E ++     QE L E  K + T+    
Sbjct: 2731 QHQDRVQNLR-KDFTELQKT-----------VKEREKDASSCQEQLDEFRKLVRTF---- 2774

Query: 1368 IDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREV 1427
                                    + L+    S P T           Q++ L+  L + 
Sbjct: 2775 -----------------------QKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2811

Query: 1428 STKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSE 1487
            ++K  L ++        ++CK    G   E  ++++         T  D   K    L  
Sbjct: 2812 ASKGTLVEE--------INCK----GTSLENLIMEI---------TAPDSQGKTGSILPS 2850

Query: 1488 VKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR 1547
            V   V +V   G H   K  T+    +   ++ + + Y  LG  + E ++ L+       
Sbjct: 2851 VGSSVGSV--NGYHTC-KDLTE----IQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2903

Query: 1548 KMKKEAASLSEWLSATETEL--VQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTIT 1605
            ++ KEA S+ +WL + E  L  +   +S      +  +    K  L +LE+    +  + 
Sbjct: 2904 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2963

Query: 1606 ESSAAL------QNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDG 1659
            E+ A L          E  + I EE    LN+ W R    T      L    + L  F  
Sbjct: 2964 EALAGLLVTYPNSQEAENWKKIQEE----LNSRWERATEVTVARQRQLEESASHLACFQA 3019

Query: 1660 NVAHISTWLYQAEALLD-----EIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALIL 1714
              + +  WL + E ++       I+    + Q++ V+ ++ E +    Q E + + A  +
Sbjct: 3020 AESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI 3079

Query: 1715 MNARG--SSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQ----EPLYQCL---VTTET 1765
            +   G  S S   V+ +L  +N+ + +++  + S    I Q       YQ L   ++ + 
Sbjct: 3080 LTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKV 3139

Query: 1766 FETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEML-HQPM 1824
               G   S    +    E + + +E+  E   + E++D E  + + +      ++  Q +
Sbjct: 3140 RAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL 3199

Query: 1825 EDNKKEKIRLQLL-------LLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEIN 1877
            +D  K+++    L       L   R N+++A     ++  Q+   +R+ L         +
Sbjct: 3200 KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL--------DD 3251

Query: 1878 KILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILE 1937
            K      +  +S  +  L + + E+  FQ       K      G    ++ E +  ++  
Sbjct: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQ-------KSLNQHSGSYEVIVAEGESLLLSV 3304

Query: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997
              G E   +++ L +L   W+ +++  +DR+      M++ +++   + DL  WI + + 
Sbjct: 3305 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 3364

Query: 1998 LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEK 2057
             + +       + LE + +  + +   +   +     LN   D ++   S+AD   ++++
Sbjct: 3365 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINS-SEADEDGIRDE 3423

Query: 2058 LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ----KRSTT 2113
             AG+NQ  DA+  E++ +   L+  ++++ +++     I   +  A+H ++      S  
Sbjct: 3424 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQA 3483

Query: 2114 ELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNK 2173
               +NL++LR   + ++    ++ +L      ++ D     P+    S+ L    +   +
Sbjct: 3484 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED----APDGSDASQLLHQAEVAQQE 3539

Query: 2174 ICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDK 2233
                       C+   + +       H  V+++                   S  ADLD 
Sbjct: 3540 FLEVKQRVNSGCVMMENKLEGIG-QFHCRVREM------------------FSQLADLDD 3580

Query: 2234 TITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNL 2293
             +    D +  I +   S       +E++   ++++ + K D+E    +  ++      L
Sbjct: 3581 EL----DGMGAIGRDTDS---LQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL 3633

Query: 2294 KNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR 2353
                   ++  A+ ++  ++  +    Q  +EL   ++ED        +D     EE   
Sbjct: 3634 DLLGLKRELE-ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA-- 3690

Query: 2354 KYEARLYILQQARRDPLTKQISDNQILLQE-LGPGDGIVMAFDNVLQKLLEEYGSD-DTR 2411
              EA  +++     + + +Q++D ++  +E + P    +   + + Q L++  G D D +
Sbjct: 3691 --EALQWVV-GTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ 3747

Query: 2412 NVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVD 2471
             ++   E +   W  L + +A R   L+         +  LE  L W+ + E  +     
Sbjct: 3748 GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKP 3807

Query: 2472 ASHRENALQDSILARELKQQ-MQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQ 2530
             S     ++  I  ++L Q+ + D +A +D         +G R      L + E+ T   
Sbjct: 3808 PSAEYKVVKAQIQEQKLLQRLLDDRKATVD-----MLQAEGGRIAQSAELADREKIT--- 3859

Query: 2531 HRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGG 2590
             +L+ +  RW +L +K+A+ +  LE       +   + E +  +L++ +++L    P+G 
Sbjct: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919

Query: 2591 DVPALQLQYDHCKALRRELKEKEYSVLNAV 2620
                +Q Q    KAL  +++     V  AV
Sbjct: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAV 3949



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 202/1115 (18%), Positives = 449/1115 (40%), Gaps = 144/1115 (12%)

Query: 1778 LENDIENMLKFVEKHLESSDED--EKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
            LE +++++   V + LE  ++    +  E  AQ+ + L++  + L + +           
Sbjct: 1847 LERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDT---WN 1903

Query: 1836 LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPEL 1895
              LLH +     A+ I++ K+    + +   L      V    ++L        ++V  L
Sbjct: 1904 SRLLHFQ----NAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSL 1959

Query: 1896 NTAI--YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQI------- 1946
            N  +  YED    +  +   K QLD L   I     +    +      + +++       
Sbjct: 1960 NLCLQQYEDL---KQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRS 2016

Query: 1947 -RDTLTQLNAKWDRI--NRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTC 2003
             +D L Q  A+ D +  +    +++       ++    H  L DL  W+ +AE  L    
Sbjct: 2017 FQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ 2076

Query: 2004 APGGSLDLEKARIHQ---QELEVGISSHQPSFAALNRTGDGIVQ----KLSQADGSFLKE 2056
                  DL   + +Q   ++L+  I +   SFA + +  +G ++    KLS  + + L+E
Sbjct: 2077 GRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALRE 2136

Query: 2057 KLAGLNQRWDAIVAEVKDRQPRLKGE--------------SKQVMKYRHQLDEIICWLTK 2102
            KL    ++++A+  E +  Q  L+                +K++ + + ++D ++ W+T 
Sbjct: 2137 KLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTS 2196

Query: 2103 AEHA----------MQKRSTTELGENLQELRDLTQEMEVHAEKL----KWLNRTELEMLS 2148
               +          M++ S   L +   +  D    +    EKL    + +     E+LS
Sbjct: 2197 VGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS 2256

Query: 2149 DKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIA-AHPNVQKVV 2207
             +   +         L   +   + +  E    L++ + E      T +A +   +++V 
Sbjct: 2257 QQQNFILATQSAQAFL---DQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQ 2313

Query: 2208 LVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVS 2267
             +       +Q H+               E   WL   ++ L++        E +   + 
Sbjct: 2314 TLQDELQKFLQDHK---------------EFESWLERSEKELENMHKGGSSPETLPSLLK 2358

Query: 2268 RMKITKADLEQRHPQLDYVFTLAQNLKNKASS-------SDMRTAITEKLERVKNQWDGT 2320
            R      D+      L +V    Q + +  +S       S++   + +KL+    ++   
Sbjct: 2359 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 2418

Query: 2321 QHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYIL--QQARRDP--LTKQISD 2376
                      L  ++    Q+ +  +  +  M+  EA +  L       DP  L +Q++ 
Sbjct: 2419 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 2478

Query: 2377 NQILLQELGPGDGIVMAFDNVLQKLLEEYG--SDDTRNVKETTEYLKTSWINLKQSIADR 2434
             + L +EL      V     V + ++E  G  + D R+V+ETT+ + + + +L  S+A+R
Sbjct: 2479 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2538

Query: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
             + L+      Q+ +  LE+ L+ I E E  +     +S     +Q++ LA  +K + QD
Sbjct: 2539 SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEA-LATNMKLK-QD 2596

Query: 2495 IQAEIDAHNDIFKSIDGNRQKMVKAL--GNSEEATMLQHRLDDMNQRWNDL----KAKSA 2548
            I  +         S++  R+ + + +   +S  A +LQ +L +++QR+  L    + K +
Sbjct: 2597 IARQ-------KSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKES 2649

Query: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQ--YDHCKALR 2606
            S++  L   AE +  L   L++ +        E K +M   G+ P   +   +   + L 
Sbjct: 2650 SLK-KLLPQAEMFEHLSGKLQQFM--------ENKSRMLASGNQPDQDITHFFQQIQELN 2700

Query: 2607 RELKEKEYSVLNAVDQARVFLAD--QPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQ 2664
             E+++++ + L+ ++     L+     ++  +   R    + + T     QK  K   K 
Sbjct: 2701 LEMEDQQEN-LDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT---ELQKTVKEREKD 2756

Query: 2665 SSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD--DLDADMKEAESVRNGWKPVGD 2722
            +S  +E+ +    +   +QK + +    +   + +M   +L+  ++  +S+ + W   G 
Sbjct: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816

Query: 2723 LL--IDSLQDHIEKIMAFREEIAPINFKVKT---VNDLSSQLSPLDLHPSLK----MSRQ 2773
            L+  I+     +E ++    EI   + + KT   +  + S +  ++ + + K    +   
Sbjct: 2817 LVEEINCKGTSLENLIM---EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD 2873

Query: 2774 LDDLNMRWKLL-------QVSVDDRLKQLQEAHRD 2801
            + D+N++++ L       Q S+   L +++E H++
Sbjct: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  315 bits (808), Expect = 4e-85
 Identities = 536/2784 (19%), Positives = 1118/2784 (40%), Gaps = 354/2784 (12%)

Query: 207  PIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSL---FEVLPQQVTIDAI 263
            P + + H F + Q     E  L+ ED    L   + ++  L+S     ++   Q  +  +
Sbjct: 2183 PDQDITHFFQQIQ-----ELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL 2237

Query: 264  REVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDSYQIAL 318
            R+  T  +K  KE E++A + Q    E        +    ET  ++   +  + + +  L
Sbjct: 2238 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE--L 2295

Query: 319  EEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTA--HQSSVGSVLQAGNQL 376
            E+ +  L S  D +  +  +   VEE+  +  + E  +ME+TA   Q   GS+L +    
Sbjct: 2296 EKQIEHLKSLLDDWASKGTL---VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSS 2352

Query: 377  I--TQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQLQQLSA 432
            +    G  + ++  EIQ  M+ +N ++E L     +RQ  L  +L  ME   K+   +  
Sbjct: 2353 VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQ 2412

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV---VIVDE 489
            WL   EE ++ M+        ++++   E +K+  ++LE    K+  +   +   ++   
Sbjct: 2413 WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2472

Query: 490  NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEE-----------Q 538
            NS E+             E W  +      RW R  E+ +  Q  LEE           +
Sbjct: 2473 NSQEA-------------ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 2519

Query: 539  CLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV- 597
              L+ WL EKE  +  +   +  D   L+   +++  + ++ E +RQ  +QL+E  Q + 
Sbjct: 2520 SQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 2578

Query: 598  ---GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654
               G   D S ++ ++  + + + Q+W  L  +L   S+Q+ QA+ K    Q   +DL E
Sbjct: 2579 TGPG---DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSE 2635

Query: 655  TVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTE 714
             VR   Q ++ +S   +   P   K+Q+    E +   + +  E    + + +T      
Sbjct: 2636 KVRAVGQRLSVQS--AISTQPEAVKQQLEETSEIRSDLEQLDHE----VKEAQTLCDELS 2689

Query: 715  I---KEYMKMQDTSEMKKKLK--ALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEI 769
            +   ++Y+K     E+KK+L+  AL  +  E +  AD +N+    L      + +  E  
Sbjct: 2690 VLIGEQYLK----DELKKRLETVALPLQGLEDL-AADRINRLQAALASTQQFQQMFDELR 2744

Query: 770  KNVLEKVSSEWKN--VSQHLEDLERKIQ----LQEDINAYFKQLDEL------------- 810
              + +K S + KN  +S  LE L+ ++Q     Q+ +N +    + +             
Sbjct: 2745 TWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 2804

Query: 811  --------EKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASC 862
                     ++++ K  W + +  +   +  L       Q+   ++  L P IE  +A  
Sbjct: 2805 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM 2864

Query: 863  SALM-----------------------SQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQH 899
            S L                         + S  + +    D  +   +A ++ + D +  
Sbjct: 2865 SELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAG 2924

Query: 900  LE-------NELKGQPG---------HAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKV 943
            +         EL+ + G           + E+ K ++  +  ++++ ++  + L   A  
Sbjct: 2925 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQACS 2983

Query: 944  EKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPD---------VEKLYKQEFDDVQ 994
             K L++ +   E+L+  +P +  L   T+ L ++  PD           ++ +QEF +V+
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA-PDGSDASQLLHQAEVAQQEFLEVK 3042

Query: 995  GKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQR 1054
             + N   V++   L  + +    +R   +    ++  +DG+        A   D   LQ 
Sbjct: 3043 QRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM-------GAIGRDTDSLQS 3095

Query: 1055 QLDQCSAFVN-------EIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLE 1107
            Q++    F+N       +IE  E+  ++M E E  L    + G+K      L     Q  
Sbjct: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL---DLLGLK----RELEALNKQCG 3148

Query: 1108 KLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEE 1167
            KL++    ++ +L  +  +  +  + L  + +  T AEE       ++    E+E   ++
Sbjct: 3149 KLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEE---AEALQWVVGTEVEIINQQ 3205

Query: 1168 MKRAKEDVLQKE----VRVKILKDNIKLLAAKVPSGG-----QELTSELNVVLENYQLLC 1218
            +   K  + QKE    +++K+ + N  L    + S G     Q L  ++  +   +  L 
Sbjct: 3206 LADFK--MFQKEQVDPLQMKLQQVN-GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3262

Query: 1219 NRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLES 1278
             ++  +   L+E      +    L+   +WL   EE + + +    +   V   ++  + 
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322

Query: 1279 VLRHPADNRTQI----RELGQTLIDGGILD-DIISEKLEAFNSRYEDLSHLAESKQISLE 1333
            + R   D +  +     E G+      + D + I+ +LE+  SR+ +L   A ++Q  LE
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382

Query: 1334 KQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEE 1393
              L + ++  +  + + + L   +K+L        ++  V  +  KIQ +I  H+   E+
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLA-------NSEPVGTQTAKIQQQIIRHKALEED 3435

Query: 1394 LRRNMR--------SQPLTSPESRTARG--GSQMDVLQRKLREVSTKF--------QLFQ 1435
            +  +           Q L+S  S   +G    ++D LQ +  E+  +         Q   
Sbjct: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495

Query: 1436 KPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETV 1495
                F +  ++    L  V+ +L  + VKD   DV+       + L + +   K  V+  
Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555

Query: 1496 IKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAAS 1555
            IK G+ ++++   +    + E+L  +K  Y D+    ++  + LE+A QLA K +     
Sbjct: 3556 IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 3615

Query: 1556 LSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
            L+ WL   E EL            +       K + K++ + +  L+T+ E S AL  L+
Sbjct: 3616 LTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 3675

Query: 1616 -----EGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQ 1670
                 EG + ++ +           +    ++    +   Q   +  D  +A ++    +
Sbjct: 3676 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRK 3735

Query: 1671 AEALLD-EIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPK 1729
              AL    +E+  T+ Q ++ K    ++      ++ +      +    G   + +++ K
Sbjct: 3736 LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 3795

Query: 1730 LAELNRNFEKVS-------QHIKSAKLLIAQ-----EPLYQCLVTTETF--ETGVPFSDL 1775
               L + +E +S         ++ A++L+ Q     E L   +  T     +   P  D 
Sbjct: 3796 TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDH 3855

Query: 1776 EKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
            E+L    E M +  E   E     +K+ +   Q++E+     EM+ +  +  K E +   
Sbjct: 3856 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ--KAENM--- 3910

Query: 1836 LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPEL 1895
                   Y +IK   ++QR +  L   +  S   T++  +I  +L  ++++   L +P L
Sbjct: 3911 -------YAQIKE-EVRQRALA-LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 3961

Query: 1896 NTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPE----AIQIRDTLT 1951
              A  +         K+   +L+KL      +  +  ++I  + G +    A +I+D L 
Sbjct: 3962 IPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLD 4021

Query: 1952 QLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDL 2011
            Q+   W+ I     +R+  F   +E   +F  D+  L   I + ++++ D  +PG    +
Sbjct: 4022 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4081

Query: 2012 EKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVA 2070
             K ++   E ++            +   G  ++    + +   +++ +  +N  W+ +  
Sbjct: 4082 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK 4141

Query: 2071 EVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEM- 2129
              K+R  +L+   +  ++Y+  L  +  WL      ++  +   +G +L  ++D   EM 
Sbjct: 4142 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTDLNTVKDQLNEMK 4199

Query: 2130 ----EVHAEKLKW--LNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLK 2183
                EV+ ++++   LN  + E++  K+    +RD I E L  +   W  +  ++     
Sbjct: 4200 EFKVEVYQQQIEMEKLNH-QGELMLKKATDETDRDIIREPLTELKHLWENLGEKI----- 4253

Query: 2184 ECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLV 2243
                           AH                 Q      +         + EL  WL 
Sbjct: 4254 ---------------AHR----------------QHKLEGALLALGQFQHALEELMSWLT 4282

Query: 2244 LIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMR 2303
              +++L +     GD + I   +++  + K D+      ++ V   A N   ++S+ D  
Sbjct: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV-NKAGNELLESSAGDDA 4341

Query: 2304 TAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQ 2363
            +++  +LE +   W+      E R+QQL+  +  +  +    E+    + + E++L   +
Sbjct: 4342 SSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK 4401

Query: 2364 QARRDPLT--KQISDNQILLQELGPGDGIVMAFDNVLQK----LLEEYGSDDTRNVKETT 2417
                 P T  +Q+  +  L  +L   +     ++ +L K    LL    S      +++ 
Sbjct: 4402 PTGGLPETAREQLDTHMELYSQLKAKE---ETYNQLLDKGRLMLLSRDDSGSGSKTEQSV 4458

Query: 2418 EYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHREN 2477
              L+  W  +   + +R++ LE         +  L+ F+ W+  AE ++N+    S   N
Sbjct: 4459 ALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN 4518

Query: 2478 ALQDSILARELKQQMQDIQAEIDAHNDIFKSID--GNRQKMVKALGNSEEATMLQHRLDD 2535
             +   I      ++ +    E++AH D    +D  GN+   +K L   ++  ++++ L  
Sbjct: 4519 TVLSQI------EEHKVFANEVNAHRDQIIELDQTGNQ---LKFLSQKQDVVLIKNLLVS 4569

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPAL 2595
            +  RW  +  +S      L+ + ++  +   + ++LI WL   +  L  ++ I  D   +
Sbjct: 4570 VQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 4629

Query: 2596 QLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPI-EAPEEPRRNLQSKTELTPEERA 2654
            +LQ    K  ++ L  K                 QP+ +      R L+ KT L PE+ +
Sbjct: 4630 KLQLSKHKEFQKTLGGK-----------------QPVYDTTIRTGRALKEKT-LLPED-S 4670

Query: 2655 QKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVR 2714
            QK+   +     EV++KW+++   +   Q ++++AL        A+  L   + + E   
Sbjct: 4671 QKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 4726

Query: 2715 NGWKPV-GDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQ 2773
               +PV GDL  D + + ++    F++E+      V+ +     +L       +  +  Q
Sbjct: 4727 AEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQ 4784

Query: 2774 LDDLNMRWKL---LQVSVDDRLKQ 2794
            L +L+ RW     L VS   RL+Q
Sbjct: 4785 LQELSTRWDTVCKLSVSKQSRLEQ 4808



 Score =  301 bits (771), Expect = 7e-81
 Identities = 618/3039 (20%), Positives = 1169/3039 (38%), Gaps = 458/3039 (15%)

Query: 26   SDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGST 85
            +DE + VQKKTFTKW+N    K  K  IND++ DL+DG  L+ LLE L+G  LP+E+G  
Sbjct: 73   ADERDRVQKKTFTKWVNKHLMKVRKH-INDLYEDLRDGHNLISLLEVLSGIKLPREKGRM 131

Query: 86   RVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMS 145
            R H L NV   L  L Q  V+LVNI   DI DGN KLTLGL+W+IILH+Q+ D+   +  
Sbjct: 132  RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIY--ISG 189

Query: 146  DLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKM 205
            +    ++++ LL W ++ T  Y+ +   NF++ W+DG  FNA++HR++PDL   ++V   
Sbjct: 190  ESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQ 249

Query: 206  SPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIRE 265
            S  E LE AF  A+  LG+ +LLD EDV V  PD+KS+I Y++S+++  P          
Sbjct: 250  SNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFP---------- 298

Query: 266  VETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTW- 324
                                        + P      + TEVD     YQ  ++ ++ W 
Sbjct: 299  ----------------------------KVPEGGEGISATEVDSRWQEYQSRVDSLIPWI 330

Query: 325  ----LLSAEDTFQEQDDISDDVEEVKDQFATHEAFM-MELTAHQSSVGSV---------- 369
                +L ++ TF +      +  E+K  +  +  F   E+ A +   G +          
Sbjct: 331  KQHTILMSDKTFPQ------NPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVW 384

Query: 370  LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQL 427
            ++ G   + QG   ++ E E           W  L +E ++R+  L   +  +EL  +  
Sbjct: 385  IEFGRIKLPQGYHPNDVEEE-----------WGKLIIEMLEREKSLRPAVERLELLLQIA 433

Query: 428  QQLSAWLTLTEERIQKMETCPLDD--DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVV 485
             ++       EE++   +     D   ++S Q +  E   +    E E +       + +
Sbjct: 434  NKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQI 493

Query: 486  IVDEN---SGESATAI--LEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540
            + DEN     E A  +  L+D+L  L    T + R        L   + L    L+ + L
Sbjct: 494  LRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPL 553

Query: 541  LKA-------WLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEI 593
             KA       W  +       V  S+ +D+  L   V  L    E+M+MK +     +E 
Sbjct: 554  TKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRF-VYELLSWVEEMQMKLER----AEW 608

Query: 594  GQDVGQLLDNSKASKKINSDSEEL-TQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDL 652
            G D+  +    +  + I++  EEL +   ++ +   + S N  T     LG  +     L
Sbjct: 609  GNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKL 668

Query: 653  LETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQT 712
             ET   R +                        +++  KF + +   L W+         
Sbjct: 669  KETSSFRMR-----------------------HLQSLHKFVSRATAELIWL--------- 696

Query: 713  TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNV 772
             E +E     D S+    + A      E     +E     + L +      L     K  
Sbjct: 697  NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756

Query: 773  LEKVSS------EWKN-----VSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWV 821
            +E  S+      +W       V QH+++     Q   D       L  L+  IK K    
Sbjct: 757  VEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCD 816

Query: 822  KHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDS 881
             +TS+S         L+DS   +   +        +   S + +  +P +PD V +   S
Sbjct: 817  HNTSLSRLE----DLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTIS 872

Query: 882  FLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLA 941
                     +AV D +Q      K         + +T   V++ + N+A V         
Sbjct: 873  V--------KAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPP 924

Query: 942  KVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWN--K 999
              + A++    +++  +      H+L   TK+L       +   Y ++  D+   WN  K
Sbjct: 925  PNKDAIEMASRVEQSYQKVMALWHQLHVNTKSL-------ISWNYLRKDLDLVQTWNLEK 977

Query: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            L+     + H   +I   L+A        E ++   +D ++   A   D   L+ +++ C
Sbjct: 978  LRSSAPGECH---QIMKNLQAH------YEDFLQDSRDSVLFSVA---DRLRLEEEVEAC 1025

Query: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
             A     + +  S++N  + ET +    ++ +K  ++ RL +Y+ ++ K  + +A+ ++ 
Sbjct: 1026 KA---RFQHLMKSMENEDKEET-VAKMYISELKN-IRLRLEEYEQRVVKRIQSLASSRTD 1080

Query: 1120 LSESQEKA---ANLKKDLAEMQEWMTQAEEEYLERD-FEYKSPEELESAVEEMKRAKEDV 1175
                Q+ A   A  +    ++Q+  +  +   ++ D F ++SP    S+V  ++     +
Sbjct: 1081 RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS--SSSVPTLRSELNLL 1138

Query: 1176 LQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW 1235
            ++K   V  L   + L   K          +  ++++ Y++  ++       L  + + W
Sbjct: 1139 VEKMDHVYGL-STVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHW 1197

Query: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
              L H       WL+ ++++     VL E+        E +  +      +  + +E G 
Sbjct: 1198 STLRH-------WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGS 1250

Query: 1296 TLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGE 1355
             L +       +  +LE   S  E +  +    +      ++ + ET    ++++    E
Sbjct: 1251 QLQERW---HRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAE 1307

Query: 1356 LDKQLTTYLTDRIDAF-----------QVPQEAQKIQAEISAHELTLEELRRNMRSQPLT 1404
              + L+  L+ +   F           Q  + +Q+    +  +EL L   +  + SQ  +
Sbjct: 1308 DSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKS 1367

Query: 1405 SPESRTARGGSQ------MDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAEL 1458
              + R     S       MD+  R    V+   Q  +  ++  +R+ + ++V++  K E 
Sbjct: 1368 PGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQE- 1426

Query: 1459 HVLDVKDV-----------------DPDVIQTHLDKCMKLYKTLSE----VKLEVETVIK 1497
            HV  VK++                       T ++K +   + LSE     K +V   IK
Sbjct: 1427 HVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK 1486

Query: 1498 TGRHIVQKQ----QTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMK--- 1550
            T +  + K          K + EQL +L   Y+DL        Q L+  SQLA + +   
Sbjct: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ--SQLAHQTEQKT 1544

Query: 1551 ---------KEAASLSEWLSATETELV--QKSTSEGLLGDLDTEISWAKNVLKDLEKRKA 1599
                     ++   L  W+   E  L   Q  T++  L  L    S  K++  D++ R  
Sbjct: 1545 LQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRAT 1604

Query: 1600 DLNTITESSAALQNLIEGSEPILEER-LCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFD 1658
               T+ +    ++  +E ++  L  R L  L     + +   E         Q +LE   
Sbjct: 1605 SFATVVKD---IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE--- 1658

Query: 1659 GNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNAR 1718
                          AL  E EK   +K+    K+ +  L D    V +   Q L  +   
Sbjct: 1659 ---------EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGM 1709

Query: 1719 GSSSRELVEPKLAE-------LNRNFEKVSQHIKSAK-----LLIAQEPLYQCLVTTETF 1766
               S   +E    +       +N+  EK+ +  +  K     LL  Q+       + + F
Sbjct: 1710 EQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF 1769

Query: 1767 -----------ETGVPFSDLEKLENDIENMLKFVEKHLES----SDEDEKMDEESAQIEE 1811
                       E  +    L +L+      L   E  L+      DE +K  ++  + E 
Sbjct: 1770 LDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFES 1829

Query: 1812 VLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNK--------IKAIPIQQRKMGQLASGI 1863
             L+R E+ L    +     +    LL     +++        ++ + I  +K+  + +  
Sbjct: 1830 WLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSF 1889

Query: 1864 RSSLLPT-------DYLVEINKILLCMDDVELSLNVPELNTAI--YEDFSFQEDSLK--- 1911
            +    P+       D L +  +    +      L    LN  +  Y  F    DSL+   
Sbjct: 1890 KEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG-SHLNMLLGQYHQFQNSADSLQAWM 1948

Query: 1912 -----NIKDQLDK--------LGEQIAVIHEKQPDV----------------ILEASG-- 1940
                 N++  L          L EQ+A   + Q ++                I+E  G  
Sbjct: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008

Query: 1941 -PEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELL 1999
             P+   +++T   + + +  ++   ++R     +A+ + +     L  L Q I E E+ L
Sbjct: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNL 2068

Query: 2000 ----VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
                V + + G    +++A     +L+  I+  + S  A        ++       + L+
Sbjct: 2069 EGKQVSSLSSG---VIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQ 2125

Query: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEH--AMQKRSTT 2113
             KLA ++QR++ +  + ++++  LK    Q   + H   ++  ++       A   +   
Sbjct: 2126 GKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQ 2185

Query: 2114 ELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLS-DKSLSLPERDKISESLRTVNMTWN 2172
            ++    Q++++L  EME   E L  L     E+ S   +L L +     ++LR       
Sbjct: 2186 DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR------- 2238

Query: 2173 KICREVPTTLKECIQEPSSVSQTRIAAHPNVQ--KVVLVSSASDIPVQSHRTSEISIPAD 2230
            K   E+  T+KE  ++ SS  +        V+  +  L  +   IP      S   +   
Sbjct: 2239 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2298

Query: 2231 LDKTITELADWL---VLIDQM------LKSNIVTVGDVEEINKTVSRMKITKADLEQRHP 2281
            ++   + L DW     L++++      L++ I+ +   +   KT S +    + +     
Sbjct: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV----G 2354

Query: 2282 QLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQW 2341
             ++   T     + +   SD+     EKL  V ++   +   +  R +++       LQW
Sbjct: 2355 SVNGYHTCKDLTEIQCDMSDVNLKY-EKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2413

Query: 2342 DDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
                E  EE+++  +A   +    + + +  Q   N+  L EL      +      L  L
Sbjct: 2414 ---LESKEEVLKSMDA---MSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2467

Query: 2402 LEEY-GSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQ 2460
            L  Y  S +  N K+  E L + W    +    RQ  LE     +   +        W+ 
Sbjct: 2468 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527

Query: 2461 EAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKAL 2520
            E E  + VL   S   N L         KQQ+Q +  E +A     + ++   Q ++   
Sbjct: 2528 EKELMMGVLGPLSIDPNMLNAQ------KQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581

Query: 2521 GN-SEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKD 2579
            G+ S   + +Q  L  +NQ+W +L  K  S  + ++ +  K  +    L++L + +    
Sbjct: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641

Query: 2580 EELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNA---VDQARVFLADQPIEAPE 2636
            + L  Q  I     A++ Q +    +R +L++ ++ V  A    D+  V + +Q ++  +
Sbjct: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK--D 2699

Query: 2637 EPRRNLQS-------------------KTELTPEERAQKIAKAMR-----KQSSEVKEKW 2672
            E ++ L++                   +  L   ++ Q++   +R     KQS + K   
Sbjct: 2700 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC- 2758

Query: 2673 ESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAES-------------------- 2712
              ++A     Q Q+ +  E  + L       +  + E ES                    
Sbjct: 2759 -PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 2817

Query: 2713 VRNGWKPVGDLLID---SLQDHIEKIMAFR---EEIAP-INFKVKTVNDLSSQLSPLDLH 2765
            ++N W+ +     D    L+D ++K   ++   E++ P I      +++L   L P+ L 
Sbjct: 2818 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLE 2877

Query: 2766 PSLKMSR-QLDDLNMRWKLLQV--SVDDRLKQLQEAHRD 2801
             SL  S+  L+++  R  LL++  S  D L    EA  D
Sbjct: 2878 SSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916



 Score =  259 bits (661), Expect = 4e-68
 Identities = 495/2577 (19%), Positives = 1012/2577 (39%), Gaps = 263/2577 (10%)

Query: 230  PEDVAVQLPDKKSIIMYLTSL-FEVLPQQVTIDAIREV---ETLPRKYKKECEEEAINIQ 285
            PE V  QL +   I   L  L  EV   Q   D +  +   + L  + KK  E  A+ +Q
Sbjct: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQ 2713

Query: 286  STAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEV 345
                       R +     T+       +Q   +E+ TWL   +    +   IS  +E +
Sbjct: 2714 GLEDLAADRINRLQAALASTQ------QFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 2767

Query: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
            + Q   +E F   L  H  S   ++  G  L+       EE+  +Q Q+  L   WE L 
Sbjct: 2768 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-VPPGEEKRTLQNQLVELKNHWEELS 2826

Query: 406  VESMDRQSRLHDVLMELQKKQ--LQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEH 463
             ++ DRQSRL D + + QK Q  ++ L  W+   E+   KM    +  D   L+  L   
Sbjct: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWI---EDCKAKMSELRVTLDPVQLESSLLRS 2883

Query: 464  KSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNR 523
            K++ +++E  +  +  L     I+  NS E+    + D+   + +   AV    + +   
Sbjct: 2884 KAMLNEVEKRRSLLEILNSAADILI-NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS 2942

Query: 524  LQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMK 583
            L+E+    Q L E Q   K    + E A         K Q E+  ++   A   +++E  
Sbjct: 2943 LEEMT---QRLREFQESFKNIEKKVEGA---------KHQLEIFDALGSQACSNKNLEKL 2990

Query: 584  RQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLG 643
            R   + L  +   V  L                 TQ    LV+   D S+    A   L 
Sbjct: 2991 RAQQEVLQALEPQVDYL--------------RNFTQ---GLVEDAPDGSD----ASQLLH 3029

Query: 644  MSQIPQKDLLETV-RVREQAITKKSKQELPPPPPPKKRQIHVDI-EAKKKFDAISAELLN 701
             +++ Q++ LE   RV    +  ++K E       + R++   + +   + D + A    
Sbjct: 3030 QAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA---- 3085

Query: 702  WILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTG-QILVEQMG 760
             I +   ++Q+      + +     +K  ++A E E R  +     L+  G +  +E + 
Sbjct: 3086 -IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3144

Query: 761  KE-GLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEE 819
            K+ G  TE  K   E++      V    ED  RK++   D     ++ + L+ V+ T+ E
Sbjct: 3145 KQCGKLTERGKARQEQLELTLGRV----EDFYRKLKGLNDATTAAEEAEALQWVVGTEVE 3200

Query: 820  WVKHTSISESSRQSLPSLKDSCQRELTNLLGL-HPKIEMARASCSALMSQPSAPDFVQRG 878
             +          Q      D  Q +L  + GL    I+ A   C            ++  
Sbjct: 3201 IINQQLADFKMFQK--EQVDPLQMKLQQVNGLGQGLIQSAGKDCDV--------QGLEHD 3250

Query: 879  FDSFLGRYQAVQEAVEDRQQHLENELKGQPGHA--YLETLKTLKDVLNDSENKAQVSLNV 936
             +    R+  + + V  R   L+  L     H   + + L+ L   L D+E         
Sbjct: 3251 MEEINARWNTLNKKVAQRIAQLQEALL----HCGKFQDALEPLLSWLADTEELIANQKPP 3306

Query: 937  LNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQG 995
              +   V+  +QE+K L  +L+++K  +  L  E   + ++    D EK+  Q  + ++ 
Sbjct: 3307 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ-LESLES 3365

Query: 996  KWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQ 1055
            +W +L    +     LE+I +  + F   +  I  ++   +  L   +      A +Q+Q
Sbjct: 3366 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3425

Query: 1056 LDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIAT 1115
            + +  A   +IE   + +    +I  +L S      +  +  ++   Q +  ++      
Sbjct: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485

Query: 1116 QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDV 1175
            + + L ++   A    +D  E+  W+ + E++      +    + L     +     E++
Sbjct: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545

Query: 1176 LQKEVRV-KILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSC 1234
            + ++  V + +K+   LL          +  +L+ +   Y  +         TLE+    
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 3605

Query: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRT---QIR 1291
              +     +  T WL  +EE + ++       + + +  +  + + +   ++R     + 
Sbjct: 3606 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 3665

Query: 1292 ELGQTLID------GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQM 1345
            E+ + L++         LD ++S+     N +Y+ +S     +   ++  +Q  ++ +Q 
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDA----NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 3721

Query: 1346 LQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQA---EISAHELTLEELRRNMRSQP 1402
                   + E  ++L      R++  Q   + Q  +A   +I  H+ +++EL  +     
Sbjct: 3722 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS--- 3778

Query: 1403 LTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVL----------- 1451
                E     G  Q  VLQ K   +  +++      +     L+  +VL           
Sbjct: 3779 ----EIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 3834

Query: 1452 ----DGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQ 1507
                +  +A +  L    +D + ++   ++  +L ++++E K  ++ ++K G  + ++  
Sbjct: 3835 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL-KELN 3893

Query: 1508 TDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETEL 1567
             +  + ++E+    + +Y  +  +V +    L+ A   + ++ +    +   L   E   
Sbjct: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 3953

Query: 1568 VQKSTSEGLLGDLDTE---ISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPIL-- 1622
             +      +  ++D     IS  K+   +LEK +     +      L    +G++  L  
Sbjct: 3954 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA 4013

Query: 1623 ---EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIE 1679
               +++L  +   W  ++   E+     ++     E F  ++A + T +   + ++ ++E
Sbjct: 4014 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLE 4073

Query: 1680 KKPTS-----KQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELN 1734
                      +Q E  + +  E D  + ++E +R     L+ A G + +  V   + E+N
Sbjct: 4074 SPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMN 4133

Query: 1735 RNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETF-----ETGVPFSDLEKLENDIENMLK 1787
              +E +++  K    KL  A +   Q   T +        T +    +  +  D+  +  
Sbjct: 4134 NAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD 4193

Query: 1788 FVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLL-LLHTRYNKI 1846
             + +  E   E   + ++  ++E++  +GE ML +  ++  ++ IR  L  L H   N  
Sbjct: 4194 QLNEMKEFKVE---VYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4250

Query: 1847 KAIPIQQRKM-------GQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAI 1899
            + I  +Q K+       GQ    +   +    +L    ++L     +     V E+  A 
Sbjct: 4251 EKIAHRQHKLEGALLALGQFQHALEELM---SWLTHTEELLDAQRPISGDPKVIEVELA- 4306

Query: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAV--IHEKQPDVILEASGPEAIQIRDTLTQLNAKW 1957
                  +   LKN     D L  Q  V  +++   +++  ++G +A  +R  L  +N  W
Sbjct: 4307 ------KHHVLKN-----DVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4355

Query: 1958 DRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIH 2017
            + + +   +R+      +++ + FH ++ D    +T  E  L  +   GG  +  + ++ 
Sbjct: 4356 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4415

Query: 2018 -QQELEVGISSHQPSFAALNRTGDGIVQKLSQAD---GSFLKEKLAGLNQRWDAIVAEVK 2073
               EL   + + + ++  L     G +  LS+ D   GS  ++ +A L Q+W  + ++++
Sbjct: 4416 THMELYSQLKAKEETYNQL--LDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473

Query: 2074 DRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGEN-----LQELRDLTQE 2128
            +R+ +L+       ++++ L E I WLT AE ++   S   L  N     ++E +    E
Sbjct: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANE 4533

Query: 2129 MEVHAEKLKWLNRT--ELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECI 2186
            +  H +++  L++T  +L+ LS K     +   I   L +V   W K+       ++  I
Sbjct: 4534 VNAHRDQIIELDQTGNQLKFLSQKQ----DVVLIKNLLVSVQSRWEKV-------VQRSI 4582

Query: 2187 QEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLID 2246
            +   S+   R  A                  Q H   +            +L DWL   +
Sbjct: 4583 ERGRSLDDARKRAK-----------------QFHEAWK------------KLIDWLEDAE 4613

Query: 2247 QMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAI 2306
              L S +    D ++I   +S+ K  +  L  + P  D      + LK K    +    +
Sbjct: 4614 SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKL 4673

Query: 2307 TEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQAR 2366
               L  V+++WD        RQ +LE+ ++ S Q+ D  +   + + K E +L   Q   
Sbjct: 4674 DNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVH 4733

Query: 2367 RD-PLTKQISD-NQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW 2424
             D  L   + D +++  +ELG   G V       ++L+E    DDT  VK   + L T W
Sbjct: 4734 GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRW 4792

Query: 2425 INLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSIL 2484
              + +    +Q+ LE   +  +  R  +   L+W+ EAE T+           AL D   
Sbjct: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRF-------RGALPDDTE 4845

Query: 2485 ARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEA---------TMLQHRLDD 2535
            A         +Q+ ID H +  K ++  R  +  A+   E           T ++H +  
Sbjct: 4846 A---------LQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITI 4896

Query: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEEL--KKQMPIGGDVP 2593
            +  R+ ++   +   +  LE +  +       LEEL+ W+   +  L  + Q PI  ++ 
Sbjct: 4897 IRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNID 4956

Query: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPE-EPRRNLQSKTELTPEE 2652
             ++      +    E+  K+  V + V +       +P  AP  E  R+   K+   P  
Sbjct: 4957 RVKALIAEHQTFMEEMTRKQPDV-DRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTP 5015

Query: 2653 RAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE 2709
                I        S+ + K   +N +++ WQ+    ALE+ R L  A+D L+ ++KE
Sbjct: 5016 PPMPIL-------SQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-ELKE 5064



 Score =  239 bits (609), Expect = 4e-62
 Identities = 461/2591 (17%), Positives = 1053/2591 (40%), Gaps = 307/2591 (11%)

Query: 321  VLTWLLSAEDTFQEQDDISDDV--EEVKDQFATHEAFMMELTAHQSSVGSVLQA-GNQLI 377
            VL WL S E+  +  D +S     E VK Q  +++AF+ EL  +   +  V +A    L+
Sbjct: 2410 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLV 2469

Query: 378  TQGTLSDEEEFE-IQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQL--QQLSAWL 434
            T     + E ++ IQE+   LN+RWE     ++ RQ +L +    L   Q    QL  WL
Sbjct: 2470 TYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 2526

Query: 435  TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV--VIVDENSG 492
               E  +  +    +D ++ + QK  ++ + +  + EA + +   L      ++      
Sbjct: 2527 MEKELMMGVLGPLSIDPNMLNAQK--QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 2584

Query: 493  ESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL---WQELLEE----------QC 539
              +T+ ++ +LQ + ++W  +      R +++ +  +    +QELL++          + 
Sbjct: 2585 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 2644

Query: 540  LLKAWLTEKEEALNKV--QTSNFKDQ--------KELSVSVRRLAILKEDMEMKRQTLDQ 589
             +++ ++ + EA+ +   +TS  +          KE       L++L  +  +K +   +
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704

Query: 590  LSEIGQDVGQLLDNSKASKKIN------SDSEELTQRWDSLVQRLEDSSNQ--------- 634
            L  +   +  L D   A+ +IN      + +++  Q +D L   L+D  +Q         
Sbjct: 2705 LETVALPLQGLED--LAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 2762

Query: 635  -VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVD-IEAKKKF 692
             + +  ++L  ++  QK L +     E  + +     L  PP  +KR +    +E K  +
Sbjct: 2763 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHW 2822

Query: 693  DAISAELLNWILKWKTAIQTTE-------------------IKEYMKMQDTSEMKKKL-- 731
            + +S +  +   + K  +Q  +                   + E     D  +++  L  
Sbjct: 2823 EELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLR 2882

Query: 732  -KALEKEQRERIPRADELNQTGQILVE--QMGKEGLPTEE--IKNVLEKVSSEWKNVSQH 786
             KA+  E  +R    + LN    IL+   +  ++G+  E+  I   ++ V+ E +  +  
Sbjct: 2883 SKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS 2942

Query: 787  LEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELT 846
            LE++ ++++   +    FK +++  +  K + E          S ++L  L+   Q+E+ 
Sbjct: 2943 LEEMTQRLR---EFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR--AQQEV- 2996

Query: 847  NLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAV---QEAVEDRQQ----- 898
             L  L P+++  R     L+    APD    G D+    +QA    QE +E +Q+     
Sbjct: 2997 -LQALEPQVDYLRNFTQGLVED--APD----GSDASQLLHQAEVAQQEFLEVKQRVNSGC 3049

Query: 899  -HLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA---LQEKKT 952
              +EN+L+G  Q      E    L D+ ++ +    +  +  +  +++E     L +   
Sbjct: 3050 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3109

Query: 953  LDEILENQKPALHKLAEETKALEK-NVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHL- 1010
            L   +E  +     + EE   L+   +  ++E L KQ      GK  +      + L L 
Sbjct: 3110 LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ-----CGKLTERGKARQEQLELT 3164

Query: 1011 ---LEEIALTLRAFEADSTVIEK-----WMDGVKDFLMKQQAAQGDDAGLQR-QLDQCSA 1061
               +E+    L+     +T  E+     W+ G +  ++ QQ A  D    Q+ Q+D    
Sbjct: 3165 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA--DFKMFQKEQVDPLQM 3222

Query: 1062 FVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS 1121
             + ++  +   L     I++  +   V G++  ++    +   +   L+K++A + ++L 
Sbjct: 3223 KLQQVNGLGQGL-----IQSAGKDCDVQGLEHDME----EINARWNTLNKKVAQRIAQLQ 3273

Query: 1122 ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVR 1181
            E+       +  L  +  W+   EE    +       + +++ ++E K  +  +  ++  
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333

Query: 1182 VKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLH 1240
            V +L+     +A       +E +T +L  +   +  L ++   +   LE++     +   
Sbjct: 3334 VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393

Query: 1241 YLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL---ESLESVLRHPADNRTQIRELGQTL 1297
              +  + +L+  E+++ ++E +  +T  + + +   ++LE  + + A +  Q  ++GQ+L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453

Query: 1298 --IDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGE 1355
              +       ++SEK+++  +RY ++      K   L++ L   R             GE
Sbjct: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR-----------LFGE 3502

Query: 1356 LDKQLTTYLT---DRIDAFQVPQEAQKIQAEISAHELTLEEL---RRNMRSQPLTSPESR 1409
             + ++  +L    D++ +  V    Q +     A  L L E    R+    Q + + ++ 
Sbjct: 3503 DEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL 3562

Query: 1410 TARG-GSQMDVLQRKLREVSTKF---------------QLFQKPANFEQRMLDCKRVLDG 1453
              +  G ++ ++Q KL  + T++               Q  Q    F+    +    L  
Sbjct: 3563 LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLRE 3622

Query: 1454 VKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKG 1513
            V+ EL     +    + I     +  +L K + E +L ++TV +  R +++       +G
Sbjct: 3623 VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREG 3682

Query: 1514 MDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTS 1573
            +D+ ++     Y  +   + +   +++ A Q +++ ++ A +   W++ T+ +L+     
Sbjct: 3683 LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI 3742

Query: 1574 EGLLGDLDTEISWAKNVLKDLEKRKADLNTI-TESSAALQNLIEGSEPILEERLCVLNAG 1632
                     ++   K    D+ + K  ++ + +  S       E  + +L+E+   L   
Sbjct: 3743 RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQ 3802

Query: 1633 WSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDE-----IEKKPTSKQE 1687
            +  +     +    L   Q  +  F      +S W+ +  AL+ +     I+ +   +Q+
Sbjct: 3803 YEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQ 3862

Query: 1688 EIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSA 1747
            E +++L   + +    ++ +      L         E+VE K  +    + ++ + ++  
Sbjct: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG-EMVEEKYQKAENMYAQIKEEVRQR 3921

Query: 1748 KLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN-------------DIENMLKFVEKHLE 1794
             L +  E + Q    TE  +   P   LE LEN             +++ + + +  +  
Sbjct: 3922 ALAL-DEAVSQSTQITEFHDKIEPM--LETLENLSSRLRMPPLIPAEVDKIRECISDNKS 3978

Query: 1795 SSDEDEKMDEESAQIEEVLQRGEEMLHQPM---EDNKKEKIRLQLLLLHTRYNKIKAIPI 1851
            ++ E EK+       E + +RGEE++ +     +D   ++I+ +L  +   +  IKA   
Sbjct: 3979 ATVELEKLQPS---FEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA-RA 4034

Query: 1852 QQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLK 1911
            ++R++  L     +     D    +  I    D V   L  P ++ +I +    Q ++ +
Sbjct: 4035 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH-DLESPGIDPSIIKQ---QVEAAE 4090

Query: 1912 NIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCF 1971
             IK++ D L E++  I     D+I      E  ++R ++ ++N  W+ +N+ + +R    
Sbjct: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150

Query: 1972 DRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQ-QELEVGISSHQP 2030
            + AM+   Q+   L  +  W+      L      G  L+  K ++++ +E +V +   Q 
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210

Query: 2031 SFAALNRTGDGIVQKLS-QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKY 2089
                LN  G+ +++K + + D   ++E L  L   W+ +  ++  RQ +L+G    + ++
Sbjct: 4211 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270

Query: 2090 RHQLDEIICWLTKAEHAMQKRSTTE-----LGENLQELRDLTQEMEVHAEKLKWLNRTEL 2144
            +H L+E++ WLT  E  +  +         +   L +   L  ++  H   ++ +N+   
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330

Query: 2145 EMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQ 2204
            E+L  +S +  +   +   L  +N  W  + ++     +E  Q+  S  Q     H  ++
Sbjct: 4331 ELL--ESSAGDDASSLRSRLEAMNQCWESVLQKT----EEREQQLQSTLQQAQGFHSEIE 4384

Query: 2205 KVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINK 2264
              +L  +  +  + + + +       L +T  E  D  + +   LK+        E  N+
Sbjct: 4385 DFLLELTRMESQLSASKPT-----GGLPETAREQLDTHMELYSQLKAK------EETYNQ 4433

Query: 2265 TVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGV 2324
             + + ++                 L+++     S ++   A+ E+      +W      +
Sbjct: 4434 LLDKGRL---------------MLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKM 4472

Query: 2325 ELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQ 2382
            E R+ +LE+ +  + ++ +  +E    +   E  L I        + +  QI ++++   
Sbjct: 4473 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 4532

Query: 2383 ELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEW 2442
            E+      ++  D    +L       D   +K     +++ W  + Q   +R  +L+   
Sbjct: 4533 EVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 4592

Query: 2443 RTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAH 2502
            +  +      +  + W+++AE         SH ++ L       E+      I+ ++  H
Sbjct: 4593 KRAKQFHEAWKKLIDWLEDAE---------SHLDSEL-------EISNDPDKIKLQLSKH 4636

Query: 2503 NDIFKSIDGNRQ------KMVKALGNS----EEATMLQHRLDDMNQRWNDLKAKSASIRA 2552
             +  K++ G +       +  +AL       E++  L + L ++  +W+ +  KS   + 
Sbjct: 4637 KEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQH 4696

Query: 2553 HLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEK 2612
             LE +     + + +L+ L+ WL   + +L +  P+ GD+  +    D  K  ++EL ++
Sbjct: 4697 KLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKR 4756

Query: 2613 EYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKW 2672
              +V       R  +                        E ++     ++ Q  E+  +W
Sbjct: 4757 TGTVQVLKRSGRELI------------------------ENSRDDTTWVKGQLQELSTRW 4792

Query: 2673 ESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVR--NGWKPVGDLLIDSLQD 2730
            +++  ++ + Q ++++AL++    +  +  L   + EAE      G  P     + SL D
Sbjct: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 4852

Query: 2731 HIEKIMAFREE 2741
              ++ M   EE
Sbjct: 4853 THKEFMKKVEE 4863



 Score =  231 bits (590), Expect = 7e-60
 Identities = 478/2686 (17%), Positives = 1048/2686 (39%), Gaps = 312/2686 (11%)

Query: 314  YQIALEEVLTWLLSAEDTFQE--QDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQ 371
            +Q + + +  W+ + E   ++   D ++ D   +++Q AT +    EL  HQ  V  + +
Sbjct: 1937 FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQK 1996

Query: 372  AGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQ--LQQ 429
                ++        +   +QE    + + +++L     +R S L   + + Q  Q  L+ 
Sbjct: 1997 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2056

Query: 430  LSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE 489
            L   +   E+ ++  +   L   V  +Q+ L  +  L+ D+  ++  + +   MV    E
Sbjct: 2057 LLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFME 2114

Query: 490  NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
             +  +  A+L+ +L ++ +R+  +C   +E+ + L+++ +   E+ E    L   L +  
Sbjct: 2115 TADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL-LPQAEMFEH---LSGKLQQFM 2170

Query: 550  EALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV---GQLLDNSKA 606
            E  +++  S  +  ++++   +++  L  +ME +++ LD L  +  ++   G  LD  + 
Sbjct: 2171 ENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQH 2230

Query: 607  SKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKK 666
              ++ +  ++ T+   ++ +R +D+S+   Q      + +  QK L ET        T  
Sbjct: 2231 QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2290

Query: 667  SKQELPPPPPPKKRQIHVDIEAK----KKFDAISAELLNWILK----------------- 705
            S +EL       K  +  D  +K    ++ +     L N I++                 
Sbjct: 2291 SAKELEKQIEHLKSLLD-DWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2349

Query: 706  ---------WKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP----RADELNQTG 752
                     + T    TEI+    M D +   +KL  +  E++E +     R +E+++  
Sbjct: 2350 GSSVGSVNGYHTCKDLTEIQ--CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407

Query: 753  QILVEQMGKEGLPTEEIKNVLEKVSSEWKNVS------------QHLEDLERKIQLQEDI 800
              +++ +  +    EE+   ++ +SS  K  +              LE    KIQ  ++ 
Sbjct: 2408 NSVLQWLESK----EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA 2463

Query: 801  NA----YFKQLDELEKVIKTKEE----WVKHTSISESSRQSLPSLKD--SC-QRELTNLL 849
             A     +    E E   K +EE    W + T ++ + ++ L       +C Q   + L 
Sbjct: 2464 LAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR 2523

Query: 850  GLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPG 909
                + E+       L   P+  +  ++     L  ++A ++  E   +  +  L G PG
Sbjct: 2524 PWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG-PG 2582

Query: 910  HAYLETLKTLKDV---------LNDSENKAQVSLN-----------VLNDLAKVEKALQE 949
               L T +  K++         L D  N     ++           +L DL++  +A+ +
Sbjct: 2583 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 2642

Query: 950  KKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDL- 1008
            + ++   +  Q  A+ +  EET      +  D+E+L   E  + Q   ++L VL+ +   
Sbjct: 2643 RLSVQSAISTQPEAVKQQLEETS----EIRSDLEQL-DHEVKEAQTLCDELSVLIGEQYL 2697

Query: 1009 -----HLLEEIALTLRAFE--------------ADSTVIEKWMDGVKDFLMKQQAAQGDD 1049
                   LE +AL L+  E              A +   ++  D ++ +L  +Q+ Q  +
Sbjct: 2698 KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKN 2757

Query: 1050 AGLQRQLDQCSAFVNEIETIESSLKN--------MKEIETNLRSGPVAGIKTWVQTRLGD 1101
              +  +L++  + + E E  + SL          + E E+ L S P    K  +Q +L +
Sbjct: 2758 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 2817

Query: 1102 YQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEEL 1161
             +   E+LSK+ A ++SRL +  +KA   +  + ++  W+   + +  E       P +L
Sbjct: 2818 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-DPVQL 2876

Query: 1162 ESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRI 1221
            ES++   K    +V ++   ++IL     +L     +    +  E   + +N   +   +
Sbjct: 2877 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 2936

Query: 1222 RGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVN---------EA 1272
            + K  +LEE+           + + ++ N +E++++  +   E  DA+          E 
Sbjct: 2937 QAKTGSLEEMTQ------RLREFQESFKN-IEKKVEGAKHQLEIFDALGSQACSNKNLEK 2989

Query: 1273 LESLESVLRHPADNRTQIRELGQTLI----DGGILDDIISEKLEAFNSRYEDLSHLAESK 1328
            L + + VL+        +R   Q L+    DG     ++ +  E     + ++     S 
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA-EVAQQEFLEVKQRVNSG 3048

Query: 1329 QISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHE 1388
             + +E +L+ + +    ++ +   L +LD +L     D + A  + ++   +Q++I    
Sbjct: 3049 CVMMENKLEGIGQFHCRVREMFSQLADLDDEL-----DGMGA--IGRDTDSLQSQIEDVR 3101

Query: 1389 LTLEE---LRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRML 1445
            L L +   L+ ++ +            G   +  L+R+L  ++ +     +     Q  L
Sbjct: 3102 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3161

Query: 1446 --------DCKRVLDGVK------AELHVLD-VKDVDPDVIQTHL-DKCMKLYKTLSEVK 1489
                    D  R L G+        E   L  V   + ++I   L D  M   + +  ++
Sbjct: 3162 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQ 3221

Query: 1490 LEVETVIKTGRHIVQKQQTD-NPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK 1548
            ++++ V   G+ ++Q    D + +G++  +  +   +N L  +V +    L+ A     K
Sbjct: 3222 MKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGK 3281

Query: 1549 MKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESS 1608
             +     L  WL+ TE  +  +         +  +I   K + + L+ RKA ++ +    
Sbjct: 3282 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3341

Query: 1609 AALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI-------FDGNV 1661
              +    E     L +R  +     S    WTE   +     Q QLE        F    
Sbjct: 3342 GRIAQSAE-----LADREKITGQLESLESRWTE-LLSKAAARQKQLEDILVLAKQFHETA 3395

Query: 1662 AHISTWLYQAEALLDEIEKKPTSK---QEEIV--KRLVSELDDANLQVENVRDQALILMN 1716
              IS +L   E  L   E   T     Q++I+  K L  ++++    V         L +
Sbjct: 3396 EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSS 3455

Query: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLE 1776
                + + ++  K+  L   + ++         L+ Q      L   +  E     +++E
Sbjct: 3456 LTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 3515

Query: 1777 -KLENDIENMLKFVEKHLESSDE---DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKI 1832
             KL +      K    H + +D    +E++      +++ ++ G+ +L Q   +      
Sbjct: 3516 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE------ 3569

Query: 1833 RLQLLLLHTRYNKIKA----IPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVEL 1888
              ++LL+  + + IK     I +   K  +     R   L T +     ++   + +VE 
Sbjct: 3570 --EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ--LATKFQSTYEELTGWLREVEE 3625

Query: 1889 SLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948
             L      +   E     +   K +K ++ +    +  ++E     +LE     A +  D
Sbjct: 3626 ELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR-ALLELVPWRAREGLD 3684

Query: 1949 TL-TQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGG 2007
             L +  N ++  ++     R    D A++  +Q+    +    W+ E +  L+       
Sbjct: 3685 KLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRL 3744

Query: 2008 SLDLEKARIH-QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWD 2066
              D   A++  Q+   + I  H+ S   L      I     +   + L+EK   L Q+++
Sbjct: 3745 EQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 3804

Query: 2067 AIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-----ELGENLQE 2121
            AI     +R  RL+     V ++    +E+  W+ +    + +  +      +L +  +E
Sbjct: 3805 AISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864

Query: 2122 LRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREV--- 2178
            +R L + +  H   +  L +   ++   K L+  E + + E  +     + +I  EV   
Sbjct: 3865 MRQLRESIAEHKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQR 3921

Query: 2179 PTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITEL 2238
               L E + + + +++      P ++ +  +SS   +P          IPA++DK     
Sbjct: 3922 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL--------IPAEVDK----- 3968

Query: 2239 ADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
                                   I + +S  K    +LE+  P  + +    + L  ++ 
Sbjct: 3969 -----------------------IRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005

Query: 2299 SSDMRTA---ITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355
             +D   A   I +KL+++   W+  +   E R+ +  D++  + ++          ++  
Sbjct: 4006 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4065

Query: 2356 EARLYILQQARRDP-LTKQISDNQILLQELGPGDGIVMAFDNVL-QKLLEEYGSDDTRNV 2413
            +  ++ L+    DP + KQ  +    ++E   G    + F  +L   L+   G  +   V
Sbjct: 4066 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4125

Query: 2414 KETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDAS 2473
            +++ + +  +W NL ++  +R   LE   +     +  L+    W+      +  +    
Sbjct: 4126 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG 4185

Query: 2474 HRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRL 2533
               N ++D +       +M++ + E+       + ++   + M+K   +  +  +++  L
Sbjct: 4186 TDLNTVKDQL------NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPL 4239

Query: 2534 DDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVP 2593
             ++   W +L  K A  +  LE +     +   +LEEL+ WL   +E L  Q PI GD  
Sbjct: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299

Query: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEER 2653
             ++++      L+ ++   + +V          L                       E  
Sbjct: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELL-----------------------ESS 4336

Query: 2654 AQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESV 2713
            A   A ++R +   + + WES+   T   ++Q+   L++ +     ++D   ++   ES 
Sbjct: 4337 AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQ 4396

Query: 2714 RNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-----LSPLDLHPSL 2768
             +  KP G L     +   E++    E  + +  K +T N L  +     LS  D     
Sbjct: 4397 LSASKPTGGL----PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4452

Query: 2769 KMSRQLDDLNMRWKLLQVSVDDRLKQLQEA---HRDFGPSSQHFLS 2811
            K  + +  L  +W ++   +++R  +L+EA     +F  S Q F++
Sbjct: 4453 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 4498



 Score =  204 bits (519), Expect = 1e-51
 Identities = 481/2653 (18%), Positives = 1044/2653 (39%), Gaps = 322/2653 (12%)

Query: 318  LEEVLTWLLSAEDTFQEQDDISDDVE--EVKDQFATHEAFMMELTAHQSSVGSVLQAGNQ 375
            ++E+L W+ +     Q +   S+  E  +++      +    ELT  +  V   ++    
Sbjct: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490

Query: 376  LITQG--TLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLME------LQKKQ- 426
             + +    LS++E+ +I EQ+  LN  +  L   S ++  +L   L        LQK+Q 
Sbjct: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550

Query: 427  -----LQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLT 481
                 L+ L +W+   E  +   +      D+ +LQK   + K LQ D++      N  T
Sbjct: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604

Query: 482  HMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLL 541
                +V +  G      +E+   KL  R     R       +L +    ++ L EE  + 
Sbjct: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653

Query: 542  KAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLL 601
            +  L E   +  + +T   K  KEL+ + +++  L          LD ++ +G   GQLL
Sbjct: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDAL----------LDWVTSVGSSGGQLL 1703

Query: 602  DNSKASKK-------------------INSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL 642
             N    ++                   +N   E+L ++ + +  R ++  +Q    +   
Sbjct: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763

Query: 643  GMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNW 702
              +Q         +   EQ + ++   EL         Q   +++  +       + L  
Sbjct: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQD 1823

Query: 703  ILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQ----RERIPRADEL---NQTGQ-- 753
              ++++ ++ +E KE   M       + L +L K Q     + I    +L     +GQ  
Sbjct: 1824 HKEFESWLERSE-KELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV 1882

Query: 754  ILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERK-IQLQEDINAYFKQLDELEK 812
            + +E   KEG    EI N+   V  + K+ ++    L  K  +L   +N    Q  + + 
Sbjct: 1883 LDMENSFKEGKEPSEIGNL---VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939

Query: 813  VIKTKEEWVK--HTSISESSRQSLPSLKDSCQRELTNLLGLH----------PKIEMARA 860
               + + W++    ++ +    ++ S     Q +L     L            K++    
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999

Query: 861  SCSALMSQPSAPD--FVQRGFDSFLGRYQAVQEAVEDRQQHLENEL-KGQPGHAYLET-L 916
                +  +P APD   VQ   DS L  +Q++  ++ +R   L+  + + Q     LE+ L
Sbjct: 2000 DIMEIEGEP-APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058

Query: 917  KTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEK 976
            +++ +V  + E K   SL+       +++AL     L + +  QK +L    E      +
Sbjct: 2059 QSIGEVEQNLEGKQVSSLS----SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFME 2114

Query: 977  NVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVK 1036
                    + + +  +V  ++ +L +   +    L+++      FE  S  ++++M+   
Sbjct: 2115 TADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKS 2174

Query: 1037 DFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQ 1096
              L        D     +Q+ + +    E+E  + +L  ++ + T L S   A      Q
Sbjct: 2175 RMLASGNQPDQDITHFFQQIQELNL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQ 2231

Query: 1097 TRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYK 1156
             R+ + +    +L K +  ++   S  QE+    +K +   Q+W+ + E      +    
Sbjct: 2232 DRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-M 2290

Query: 1157 SPEELESAVEEMKRAKED-----VLQKEVRVK--ILKDNIKLLAAK---------VPSGG 1200
            S +ELE  +E +K   +D      L +E+  K   L++ I  + A          +PS G
Sbjct: 2291 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2350

Query: 1201 QELTS-----------ELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETT-- 1247
              + S           E+   + +  L   ++ G  H  +E     +  +  +  E    
Sbjct: 2351 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2410

Query: 1248 --WLNTLEERMKSTEVL--PEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGIL 1303
              WL + EE +KS + +  P KT+ V    ES ++ L     N  +I+++ + L   G+L
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLL 2468

Query: 1304 DDIISEK--------LEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGE 1355
                + +         E  NSR+E  + +  ++Q  LE+    L         L+  L E
Sbjct: 2469 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 2528

Query: 1356 LDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRR-NMRSQPLTSPESRTARGG 1414
             +  +       ID   +  + Q++Q  +   E   ++  + N  +Q + +     +   
Sbjct: 2529 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 2588

Query: 1415 SQMDVLQRKLREVSTKF---------------QLFQKPANFEQRMLDCKRVLDGVKAELH 1459
            SQ   +Q++L+ ++ K+               Q   K   +++ + D    +  V   L 
Sbjct: 2589 SQ---VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLS 2645

Query: 1460 VLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV---ETVIKTGRHIVQKQQTDNPKGMDE 1516
            V       P+ ++  L++  ++   L ++  EV   +T+      ++ +Q   +   + +
Sbjct: 2646 VQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE--LKK 2703

Query: 1517 QLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGL 1576
            +L ++ +    L     +    L+ A    ++ ++    L  WL   +++  +       
Sbjct: 2704 RLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAK 2763

Query: 1577 LGDLDTEISWAKNVLKDLEKRKADLNTI-TESSAALQNLIEGSEP-ILEERLCVLNAGWS 1634
            L  L +++   +   K L +       I  E  + L ++  G E   L+ +L  L   W 
Sbjct: 2764 LERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWE 2823

Query: 1635 RVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDE--IEKKPTSKQEEIV-- 1690
             +   T D  + L +   + + +  +V  +  W+   +A + E  +   P   +  ++  
Sbjct: 2824 ELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS 2883

Query: 1691 KRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLL 1750
            K +++E++     +E +   A IL+N+   +  + +  + A +N+N + V++ ++ AK  
Sbjct: 2884 KAMLNEVEKRRSLLEILNSAADILINS-SEADEDGIRDEKAGINQNMDAVTEELQ-AKTG 2941

Query: 1751 IAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIE 1810
              +E      +T    E    F ++EK     ++ L+  +     +  ++ +++  AQ +
Sbjct: 2942 SLEE------MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQ-Q 2994

Query: 1811 EVLQRGEEMLH------QPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR------KMGQ 1858
            EVLQ  E  +       Q + ++  +      LL      + + + ++QR       M  
Sbjct: 2995 EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMEN 3054

Query: 1859 LASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLD 1918
               GI        +   + ++   + D++  L   +   AI  D    +  +++++  L+
Sbjct: 3055 KLEGI------GQFHCRVREMFSQLADLDDEL---DGMGAIGRDTDSLQSQIEDVRLFLN 3105

Query: 1919 KLGEQIAVIHEKQPDV--ILEASGP-EAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAM 1975
            K+      I   + +   +LE  G  + + ++  L  LN +  ++      R+   +  +
Sbjct: 3106 KIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL 3165

Query: 1976 EEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQEL--EVGISSHQPSFA 2033
                 F+  L  L    T AEE        G  +++   ++   ++  +  +   Q    
Sbjct: 3166 GRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQ 3225

Query: 2034 ALNRTGDGIVQKLSQ-ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQ 2092
             +N  G G++Q   +  D   L+  +  +N RW+ +  +V  R  +L+       K++  
Sbjct: 3226 QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDA 3285

Query: 2093 LDEIICWLTKAEH--AMQKRSTTE---LGENLQELRDLTQEMEVHAEKLKWLNRTELEML 2147
            L+ ++ WL   E   A QK  + E   +   +QE + L + ++     +  L      + 
Sbjct: 3286 LEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIA 3345

Query: 2148 SDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVV 2207
              +S  L +R+KI+  L ++   W ++                    ++ AA     + +
Sbjct: 3346 --QSAELADREKITGQLESLESRWTELL-------------------SKAAARQKQLEDI 3384

Query: 2208 LVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVS 2267
            LV     +  Q H T+E             ++D+L + ++ L ++        +I + + 
Sbjct: 3385 LV-----LAKQFHETAE------------PISDFLSVTEKKLANSEPVGTQTAKIQQQII 3427

Query: 2268 RMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELR 2327
            R K  + D+E     +     + Q+L +  S ++ +  ++EK++ ++ ++   Q     +
Sbjct: 3428 RHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRK 3486

Query: 2328 QQQLEDMIIDSLQWDDHREETEELMRKYEARL--YILQQARRDPLTKQISDNQILLQEL- 2384
               L+  + ++  + +   E    + + E +L    ++  ++D L +Q +D+  L +E+ 
Sbjct: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIV 3546

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                 +  A  N  Q LL++   ++   ++E  + +KT + ++  + +     LE   + 
Sbjct: 3547 NRKKNVDQAIKNG-QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 3605

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHR-ENALQDSILARELKQQMQDIQAEIDAHN 2503
                +   E    W++E E  +      S   E   Q     +ELK+++ + +  +D  N
Sbjct: 3606 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 3665

Query: 2504 DIFKSI-----DGNRQKMVKALGNSEEATMLQHRL--DDMNQRWNDLKAKSASIRAHLEA 2556
            ++ +++        R+ + K + ++ E    Q++L  D + QR +++ A     + + +A
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANE----QYKLVSDTIGQRVDEIDAAIQRSQQYEQA 3721

Query: 2557 S------AEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE-- 2608
            +        +  R LM+L  +    +    +L+ Q     D+   +   D   + R E  
Sbjct: 3722 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 3781

Query: 2609 ----------LKEK---------EYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELT 2649
                      L+EK           S+LN+   AR+  A   +    E    L    E T
Sbjct: 3782 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEET 3841

Query: 2650 PEERAQKIAKA-----MRKQSSEVKEKWESLNAVTSNWQK--QVDKALEKLRDLQGAM-- 2700
                AQ  + A     +R+Q  E+++  ES+     +  K  ++   L++L   +G M  
Sbjct: 3842 RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVE 3901

Query: 2701 ------DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVND 2754
                  +++ A +KE    R        L +D       +I  F ++I P+   ++T+ +
Sbjct: 3902 EKYQKAENMYAQIKEEVRQR-------ALALDEAVSQSTQITEFHDKIEPM---LETLEN 3951

Query: 2755 LSSQLSPLDLHPS 2767
            LSS+L    L P+
Sbjct: 3952 LSSRLRMPPLIPA 3964


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score =  290 bits (742), Expect = 2e-77
 Identities = 597/3145 (18%), Positives = 1243/3145 (39%), Gaps = 530/3145 (16%)

Query: 17   EFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPP--INDMFTDLKDGRKLLDLLEGLT 74
            + +++++   DE   VQK+TFTKWIN+  +K  KPP  ++D+F D+KDG KLL LLE L+
Sbjct: 13   DIANVMQRLQDEQEIVQKRTFTKWINSHLAKR-KPPMVVDDLFEDMKDGVKLLALLEVLS 71

Query: 75   GTSLPKERGST--RVHALNNVNRVLQVL------HQNN-VELVNIGGTDIVDGNHKLTLG 125
            G  LP E+G    R+HA+ N+   L+ L      H+ + ++LVNI  TDI DG   + LG
Sbjct: 72   GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLG 131

Query: 126  LLWSIILHWQVKDVMKDV-----------------------------MSDLQQTNSEKIL 156
            L+W+IIL++Q++++  ++                             ++   Q N++K L
Sbjct: 132  LMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKAL 191

Query: 157  LSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFS 216
            L WV+ T    + + V +F  SW  G+AF++V+H  +P+L   + V   S  E LE AF+
Sbjct: 192  LKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFT 251

Query: 217  KAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKE 276
             A+T LGI +LLDPEDV V  PD+KSI+ Y+    +  P                     
Sbjct: 252  IAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPD-------------------- 291

Query: 277  CEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQD 336
                 I+  ST  +E+ E      PS    V       ++  +E+  W+   E       
Sbjct: 292  -----IHNASTDGQEDDEI-LPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ 345

Query: 337  DISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTL 396
             +  +++   D++ + + F ++    +  +  ++Q    L   G LS +           
Sbjct: 346  MVESNLQ---DKYQSFKHFRVQYEMKRKQIEHLIQ---PLHRDGKLSLD----------- 388

Query: 397  LNARWEALRVESMDR-QSRLHDVLMELQKK---QLQQLSAWLTLTEERIQKMETCPL--D 450
                 +AL  +S DR  SRL D  ++L K     L  + AWL   E  +++  T     +
Sbjct: 389  -----QALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHE 443

Query: 451  DDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERW 510
            +   ++Q+ LE+HK L  + +A +   +        +      +   +  DQL+ + ER+
Sbjct: 444  ETANTIQRKLEQHKDLLQNTDAHKRAFHE-------IYRTRSVNGIPVPPDQLEDMAERF 496

Query: 511  TAVCRWTEERWNRLQEINI---LWQELLEEQCLLKAWLTE--KEEALNK--------VQT 557
              V   +E    +++ + +   L   L+  +  LK+W+ +  + E++ +        ++ 
Sbjct: 497  HFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIEN 556

Query: 558  SNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE-------IGQDVGQLLDNSKASKKI 610
            S F +Q E++       ILK+  EM  +    + E       + +   Q  + S   + +
Sbjct: 557  SKFFEQYEVTYQ-----ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSV 611

Query: 611  NSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLET--------------- 655
             S  EE+   WD     +      +  A   L  S+  +KD                   
Sbjct: 612  RSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAG 671

Query: 656  ---VRVREQAITKKSKQELPPPPPPKKRQIHVDIE---AKKKFDAISAELLNWILKWKTA 709
               +   ++ +++  KQ+L      + R++ ++++      + D +  E  + ++   +A
Sbjct: 672  NFLIETCDEMVSRDLKQQL-LLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT-LSA 729

Query: 710  IQTTEIKEYMKMQDTSEMKKKLKALEKEQ-RERIPRADE----LNQTGQILV----EQMG 760
              T   K+  +  + S M  KL   + E   +R+P  D     + +T  ++     ++ G
Sbjct: 730  FATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEG 789

Query: 761  KEGLPT-EEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINAYFKQLDELEKVIKTKE 818
            KE   T  ++K  L KV   +  +    + L   + +L++ + +++  L ++ ++I   E
Sbjct: 790  KEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLE 849

Query: 819  EWVKHTSISESSRQSLPSLKDSCQRELT-----------------------------NLL 849
               + +++ +   Q L + +++C++ LT                              + 
Sbjct: 850  REAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIA 909

Query: 850  GLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAV----QEAVEDR-------QQ 898
             +H   +                  + + F+      + V    QE +E++       ++
Sbjct: 910  DIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRR 969

Query: 899  HLE--NELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTL--- 953
            H E  ++L  +  +A+L+    L D+L + E   Q     +  L K  K LQ +      
Sbjct: 970  HTEFFSQLDQRVLNAFLKACDELTDILPEQEQ--QGLQEAVRKLHKQWKDLQGEAPYHLL 1027

Query: 954  --------DEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS 1005
                    +  L + +    +L  ETK + +     + K ++  F D +G  +    L  
Sbjct: 1028 HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD-KGPHH----LCE 1082

Query: 1006 KDLHLLEEIALTL------RAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
            K L L+EE+ + L      R       V  K +    D   ++     D    +    + 
Sbjct: 1083 KRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK--WKDYTSRF 1140

Query: 1060 SAFVNEIETIESSLKNMK--EIET-----------NLRSGPVAGIKT--WVQTRL----- 1099
            S F + I T E+ LK +K   I+T            +R+G     +T  W+++RL     
Sbjct: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200

Query: 1100 ----GDYQTQ---LEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERD 1152
                 + Q Q   L KLS       + LSE ++  +N   D  + +E +  + EE +   
Sbjct: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF-GDCVQYKEIVKNSLEELISGS 1259

Query: 1153 FEYKSPEELESAVEEMKRAKEDVL---QKEVRVKILKDNIKLLAAK-------VPSGGQE 1202
             E +   E     E +  A++ +L   QK  R+   K +++   A+       +P  G E
Sbjct: 1260 KEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHE 1319

Query: 1203 LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW-------IELL------HYLDLETTWL 1249
               +L   L+  +    R   +       W  +       +  L      H   L  + L
Sbjct: 1320 ELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL 1379

Query: 1250 NTLEERMKSTEVLPEKTDAVNEALESL-------------ESVLRHPADN-RTQIRELGQ 1295
             +L   ++ T+   ++T+++    E+L             + +L+  A + + Q+++L  
Sbjct: 1380 ESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439

Query: 1296 TLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRET----DQMLQVLQE 1351
            TL +     +++  K + F S +E LS     K    EK+L  L  +    D  +  ++ 
Sbjct: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEK----EKELNALETSSSAMDMQISQIKV 1495

Query: 1352 SLGELDKQLTTYLTDRIDA-----FQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSP 1406
            ++ E++ +L++ +    +A     F    E+ +I+A+++      EELR + +       
Sbjct: 1496 TIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL----- 1550

Query: 1407 ESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDV 1466
            E       SQ    +  LR++       Q  + FE          D +   + +      
Sbjct: 1551 EGTILGHLSQQQKFEENLRKIQ------QSVSEFE----------DKLAVPIKICSSATE 1594

Query: 1467 DPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYN 1526
               V+Q H+D C    + L  +   +     + R +V      N     ++  +L+  Y 
Sbjct: 1595 TYKVLQEHMDLC----QALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYE 1644

Query: 1527 DLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISW 1586
            D+  +  E +  LE      ++++KE +S   WL   E     K++S     ++D     
Sbjct: 1645 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEA----KASSP----EMDISADR 1696

Query: 1587 AKNVLKDLEKRKADLNTITESSAALQNLIEGSEPI-----------LEERLCVLNAGWSR 1635
             K V  +L+  +A  N +   ++    L++  E +           ++  L  L+  W  
Sbjct: 1697 VK-VEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755

Query: 1636 VRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV- 1694
            +        N L +   + + FD  +   S W+   +  L E++   T+ +  I+   V 
Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLFLSELQ---TTSEISIMDHQVA 1809

Query: 1695 --------SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKS 1746
                    +E++    ++++++     L +   +    L++ K  +  + FE+ SQ ++ 
Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1869

Query: 1747 AKLLIA------QEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE 1800
             +L ++      Q       +  +  +T    + + K E+D+      +EK L  + ++ 
Sbjct: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNA 1923

Query: 1801 KMDEESA-QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIK-AIPIQQRKMGQ 1858
            K  E +A  ++ +L + +  L +     ++   R     L     +I+  +  +Q +   
Sbjct: 1924 KALESAAVSLDGILSKAQYHL-KIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADA 1982

Query: 1859 LASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLD 1918
            LA      +L   +  +  ++L  ++D+E   +   L     +    +      ++D+L+
Sbjct: 1983 LA------VLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELN 2036

Query: 1919 KLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEW 1978
                ++  + +K    I +     A ++   + +L   WD   R+  + +G     ++  
Sbjct: 2037 SHEHELCWLKDKAKQ-IAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM 2095

Query: 1979 RQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRT 2038
            R++    + +++ +  A  ++V         DL+ A    +  +  ++  Q         
Sbjct: 2096 REYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSK 2155

Query: 2039 GDGI---VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDE 2095
            G  +   ++K+  +D S +K  +     +W  +  ++++   RL+             DE
Sbjct: 2156 GKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2215

Query: 2096 IICWLT-----------------KAEHAMQKRST---------TELGENLQELRDLTQEM 2129
            I  W                   +AE  +++  +          EL   + +L++LT+ +
Sbjct: 2216 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2275

Query: 2130 EV----------------HAEKLKWLNRTELEMLSDKSLSLPE--------RDKISESLR 2165
            E                 HA+++  + +  L+  + +S  + +          K+ ESL 
Sbjct: 2276 ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL- 2334

Query: 2166 TVNMTWNKIC---REVPTTLKECIQEPSSVSQTRIAAHPNVQK----------------V 2206
             +N   N+ C   ++V    KE   + S++S T+   +   +K                +
Sbjct: 2335 -MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLI 2393

Query: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
                + S +  ++  + + S+     +++ E  +W +      K +    GD + +   +
Sbjct: 2394 KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2453

Query: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
              ++     +     +LD V    Q L     S  + ++I E++ +   ++         
Sbjct: 2454 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHL-SKQIVSSIQEQITKANEEFQAFLKQCLK 2512

Query: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYI--LQQARRDPLTKQISDNQILLQEL 2384
             +Q L+D   +   ++D   +    + + E R     L ++++    K+   N++   E+
Sbjct: 2513 DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK---NEVHKVEM 2569

Query: 2385 GPGDGIVM--AFDNVLQK--LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEA 2440
              G+ +    + D + Q+  LL E G    +  +  ++ L TS  NL +   ++  + + 
Sbjct: 2570 FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLL-TSHQNLLRMTKEKLRSCQV 2628

Query: 2441 EWRTVQASRRDLENFLKWIQE-------AETTVNVLVDASHRENALQDSILARELKQQMQ 2493
              +  +A    L++   W++        AE+T+        R + +QD +L +       
Sbjct: 2629 ALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKG------ 2682

Query: 2494 DIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAH 2553
              + E+  +  I K     R        N E   ++Q +L+ + + W D+ + S   ++ 
Sbjct: 2683 --EGEVKLNMAIGKGEQALRS------SNKEGQRVIQTQLETLKEVWADIMSSSVHAQST 2734

Query: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKE 2613
            LE+   +WN  +    +L +W+   D++++  +     +    +  DH +++  E ++  
Sbjct: 2735 LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHT 2794

Query: 2614 YSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWE 2673
             ++   + ++R        E+ ++  +  + KT+        K  + MRK    VK+   
Sbjct: 2795 RALHRLIAKSRELYEKTEDESFKDTAQE-ELKTQFNDIMTVAK--EKMRKVEEIVKDHLM 2851

Query: 2674 SLNAV--TSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDH 2731
             L+AV   ++W     + L +  D+ G   D  A  K+   ++         LIDS +  
Sbjct: 2852 YLDAVHEFTDWLHSAKEELHRWSDMSG---DSSATQKKLSKIKE--------LIDSREIG 2900

Query: 2732 IEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDR 2791
              ++    E +AP   +VK     ++  S  +L     M  ++  L   WK  + SV   
Sbjct: 2901 ASRLSRV-ESLAP---EVKQ----NTTASGCEL-----MHTEMQALRADWKQWEDSVFQT 2947

Query: 2792 LKQLQEAHRDFGPSSQHFLSTSVQL 2816
               L+        S Q F     QL
Sbjct: 2948 QSCLENLVSQMALSEQEFSGQVAQL 2972



 Score =  154 bits (388), Expect = 2e-36
 Identities = 505/2769 (18%), Positives = 1069/2769 (38%), Gaps = 385/2769 (13%)

Query: 303  TVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATH---------E 353
            T+ EV  D+ S  +  +  L  ++S  + + E+ +  +   E  DQ   H         E
Sbjct: 2716 TLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775

Query: 354  AFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQS 413
             F+  L  H  S+ S  +   + + +      E +E  E  +  +   E L+ +  D  +
Sbjct: 2776 KFV--LLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMT 2833

Query: 414  RLHDVLM---ELQKKQLQQLSA------WLTLTEERIQKMETCPLDDDVKSLQKLLEEHK 464
               + +    E+ K  L  L A      WL   +E + +     +  D  + QK L + K
Sbjct: 2834 VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD--MSGDSSATQKKLSKIK 2891

Query: 465  SLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL 524
             L    E    +++ +  +   V +N+  S   ++  ++Q L   W    +W +  +   
Sbjct: 2892 ELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWK---QWEDSVFQTQ 2948

Query: 525  QEI-NILWQELLEEQ-----------------CLLKAWL----------TEKE------- 549
              + N++ Q  L EQ                  LLK W           T++E       
Sbjct: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008

Query: 550  -----EALNKVQ--TSNFKDQ--------KELSVSVRRLA-ILKE----------DMEMK 583
                 +AL K +  T + K Q        ++LS    +++ ++KE            + K
Sbjct: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNK 3068

Query: 584  RQTLDQ-LSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL 642
             Q L Q   +  +D  Q L N+K +     D  +      + +Q++++  ++      KL
Sbjct: 3069 EQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKL 3128

Query: 643  GMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAK-----------KK 691
             M  + + +LL T+  +E+A   K  Q          +  H ++  K           K 
Sbjct: 3129 NM-MLSKGELLSTLLTKEKA---KGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKD 3184

Query: 692  FDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQT 751
            F+  +  + +W+ K +  +  +  + Y       E ++KL+++ +E     P+ + L + 
Sbjct: 3185 FEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE-QQKLQSVLEEIHCYEPQLNRLKEK 3243

Query: 752  GQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELE 811
             Q L E        ++  ++ + ++SS++  +S   ++   K+   + I A   Q     
Sbjct: 3244 AQQLWEGQAA----SKSFRHRVSQLSSQYLALSNLTKE---KVSRLDRIVAEHNQFS--- 3293

Query: 812  KVIKTKEEWVK---HTSISESSRQSLPSLKDSCQRELTNLLG------LHPKIEMARASC 862
              IK  ++W+    H   S     S  S+ DS   +L  LL       +  K+ + R   
Sbjct: 3294 LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGES 3353

Query: 863  SALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDV 922
                + P     +Q+   S    + ++  A    +  LE  L      +Y + ++     
Sbjct: 3354 VLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWT--SYQDGVRQFSGW 3411

Query: 923  LNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDV 982
            ++  E     S     +L      L + K L+E + +    L  +  E K      H   
Sbjct: 3412 MDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI--EVKGAGMTEH--- 3466

Query: 983  EKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQ 1042
              + + E  D+Q ++  ++    + +   E++    + ++ D    E W+          
Sbjct: 3467 -YVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL---------- 3515

Query: 1043 QAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTR---- 1098
                G +   Q +LDQ S    +  T E++L++++E++ +   G  A + + + TR    
Sbjct: 3516 ----GQE---QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQ-ALLNSVLHTREDVI 3567

Query: 1099 -LGDYQTQ---LEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154
              G  Q +   LE L ++    + RLSE++ +  N+   L  M++   Q +E +L+   E
Sbjct: 3568 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDE-WLKTAEE 3626

Query: 1155 YKSPEELESAVEEMK----RAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVV 1210
             K  EE+ +  +E++    RA+E + +  V             +++     +LTS     
Sbjct: 3627 KKWHEEVTAYRDEVEEVGARAQEILDESHVN------------SRMGCQATQLTSR---- 3670

Query: 1211 LENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAV- 1269
               YQ L  ++  +   LEE      E    L   + W  +  +  K+     +K D V 
Sbjct: 3671 ---YQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVM 3727

Query: 1270 -NEALESLESVLRHPADNRTQI---RELGQTLIDGGILDDIISEKL-EAFNSRYEDLSHL 1324
              + L++LE +L+      + +   RE G+  +    L++  +E+L +  +   E L  L
Sbjct: 3728 MGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVK--YLEEGEAERLRKEIHDHMEQLKEL 3785

Query: 1325 AES---KQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQK-- 1379
              +   + ++LEK L + +E     + L + + E  + L      +++ ++   +  K  
Sbjct: 3786 TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYK 3845

Query: 1380 -IQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREV-STKFQLFQKP 1437
             +Q  + +HE +++ +R    +  L   +  T +   ++D LQ   +++ S    + ++ 
Sbjct: 3846 SLQQTVLSHEPSVKSVREKGEAL-LELVQDVTLK--DKIDQLQSDYQDLCSIGKAMMEEI 3902

Query: 1438 ANFEQRMLDCK--------RVLDGVKAEL------HVLDVKDVDPDV------------- 1470
            A FE R+ + +        +  D ++A+L      H+   KD    +             
Sbjct: 3903 AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 3962

Query: 1471 -IQTHL---DKCMKLYKTLSEVKLEVET----------VIKTGRHIVQKQQTDNP----- 1511
             +Q H+   D   +    LS V+ ++E            IK  +H    Q+         
Sbjct: 3963 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLL 4022

Query: 1512 -KGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR---KMKKEAASLSEWLSATETEL 1567
                D    S+K    D+       +Q L +A  L +   ++K   + L  +L   + +L
Sbjct: 4023 CSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQL 4082

Query: 1568 --VQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEER 1625
              +++  SE  L      +S  K+ +K L+ ++A +NTI E    L    E  E    + 
Sbjct: 4083 QNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE---HKE 4139

Query: 1626 LCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK---KP 1682
            +  LN  W  +   + + C        +   +   +  +  +L +     D + +   + 
Sbjct: 4140 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4199

Query: 1683 TSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQ 1742
            T+   E +K+L   L +    +E+++DQ   ++       +ELV+ + + L + + ++  
Sbjct: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4259

Query: 1743 HIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKM 1802
             IK  K+ ++   L +  V    F+  + +++ E+  N  E +     K     D  + +
Sbjct: 4260 LIKR-KIQVSVTNLEELNVVQSRFQELMEWAE-EQQPNIAEAL-----KQSPPPDMAQNL 4312

Query: 1803 DEESAQIEEVLQRGEEMLHQPMED----------NKKEKIRLQLLLLHTRYNKIKAIPIQ 1852
              +   I   L+  + +L   ++D          N+++ I+  L    +  N +  +  Q
Sbjct: 4313 LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQ 4372

Query: 1853 QRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKN 1912
            +RK    A   +     T +L+ + +    +   E  +   E    + +D S Q  + K+
Sbjct: 4373 RRKYLNKALSEK-----TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKS 4427

Query: 1913 IKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFD 1972
             +  L     ++  +  +  +++ E +  E  ++   L +L + +D + +  S R    +
Sbjct: 4428 AQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELE 4487

Query: 1973 RAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEV-GISSHQPS 2031
            + +   + F  D +    W+ +A+ +      P  +L  E + +H Q  +   I    P 
Sbjct: 4488 KNLVSRKHFKEDFDKACHWLKQADIVTF----PEINLMNESSELHTQLAKYQNILEQSPE 4543

Query: 2032 FA----ALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVM 2087
            +      L RTG  I+  L++ D S+L EKL  L ++++ IVA  KD+  +++       
Sbjct: 4544 YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARK 4603

Query: 2088 KYRHQLDEIICWLTKAEHAMQKRS--TTELGEN------------LQELRDLTQEMEVHA 2133
            +Y   ++     L++ E    + S   T+L               L E+  L + ++   
Sbjct: 4604 EYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4663

Query: 2134 EKLKWLNRTELEMLSDKSLSL-----------PERDKISESLRTVNMTWNKICREVPTTL 2182
            +K +    T      DK L L            +R  + E   +      K+C+++   L
Sbjct: 4664 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4723

Query: 2183 KECIQEPSSVSQTRIAAHPNVQKV-VLVSSASD-------IPVQSHRTSEISIPADLDKT 2234
            K   +E S V++  + A   ++    L  S  D       + +     +    P   +K 
Sbjct: 4724 KSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKA 4783

Query: 2235 ITELADWLVLIDQMLKSNIVTVGDVE-----------EINKTVSRMKITKADLEQRHPQL 2283
              ++  W   +  +  +   TV + E           E+++++  ++  KA+L       
Sbjct: 4784 RHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP---- 4839

Query: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKN-----QWDGTQHGVELRQQQLEDMIIDS 2338
             Y+    Q+++ +     +     +   R+ N     + +      EL    LE  + + 
Sbjct: 4840 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4899

Query: 2339 LQWDDHREETEELMRKYEARL-YILQQARR-----DPLTKQISDNQILLQELGPGDGIVM 2392
             + D    + +E +R  +A L  I  Q +R           + D Q LLQ  G G  +  
Sbjct: 4900 SELDG---DIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVES 4956

Query: 2393 AFDNVLQKLLEEYGSDDT--RNVKETTEYLKTSWINLKQSIAD--RQNALEAEWRTVQAS 2448
            A +N L+  +E + ++D    N++E    + T    +K +  +   Q     E R+ + S
Sbjct: 4957 AEEN-LKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015

Query: 2449 R----------RDLENFLKWIQEAETTVNVLVDASHR--ENALQDSILARELKQQMQDIQ 2496
            R          R    +  + +  E  + ++ D   +  E +L  +  + E ++++ + +
Sbjct: 5016 RDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHK 5075

Query: 2497 AEIDAHNDIFKSIDGNRQK--MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHL 2554
            A +   N   + I    +K   ++  GN      L   +  + QRW  L+A +      L
Sbjct: 5076 ALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5135

Query: 2555 EASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEY 2614
            E + ++W      +++  + ++   ++L            L    ++      EL++++ 
Sbjct: 5136 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQS 5195

Query: 2615 SVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES 2674
            ++     Q    L D     P E    +Q  T +  ++R   + + ++     VK++ + 
Sbjct: 5196 ALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAM--QDRCLNMQEKVKTNGKLVKQELKD 5253

Query: 2675 LNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEK 2734
               V +          E    L     ++DA ++E +           +L+    +H + 
Sbjct: 5254 REMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQ-----------ILLTEATNHRQN 5302

Query: 2735 IMAFREEIAPINFKVKTV--NDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRL 2792
            I    EE       + T+  ++LS QL+ + L   LK+  Q+ D     +  + +  +  
Sbjct: 5303 IEKMAEEQKEKYLGLYTILPSELSLQLAEVAL--DLKIRDQIQDKIKEVEQSKATSQELS 5360

Query: 2793 KQLQEAHRD 2801
            +Q+Q+  +D
Sbjct: 5361 RQIQKLAKD 5369



 Score =  149 bits (377), Expect = 4e-35
 Identities = 495/2706 (18%), Positives = 1037/2706 (38%), Gaps = 390/2706 (14%)

Query: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357
            +E   T+ E       YQ +L+ + T + + E    E  +     E    Q A H+A M 
Sbjct: 5881 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMD 5937

Query: 358  ELTAHQSSVGSVLQA-GNQLITQGTLSDE-EEFEIQEQMTLLNARWEALRVESMDR---- 411
            E+   Q  +  +  +   +L+++   +D  E+  +Q  +T+L  R   +R+++  +    
Sbjct: 5938 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 5997

Query: 412  QSRLHDVLMELQKKQLQQ--------LSAWLTLTEERIQKMETCPLDD--------DVKS 455
            + +L+D L E +++Q  Q        L +WL  T+  +    + P +         D ++
Sbjct: 5998 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6057

Query: 456  LQKLLEEHKSLQSDLEA--EQVKVNSLTHMVVIVDENSG----------ESATAILEDQL 503
            +   +E+     S+L    E + +    H     ++ +G          E   A+ + QL
Sbjct: 6058 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6117

Query: 504  QKLG--------------------ERWTAVCR--WTEERWNRLQEINILWQELLEEQCLL 541
               G                    + W A  R  WT++R + LQ+   L QEL E++ LL
Sbjct: 6118 NMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLL 6177

Query: 542  KAWLTEKEEAL---NKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVG 598
            ++  +  EE L   +  +TS    +K          +L +++ M+ +      ++     
Sbjct: 6178 RSVASRGEEILIQHSAAETSGDAGEKP--------DVLSQELGMEGEKSSAEDQMRMKWE 6229

Query: 599  QLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRV 658
             L       +K+  +  E  Q      Q L    N++   V  L    +P +D      +
Sbjct: 6230 SLHQEFSTKQKLLQNVLEQEQE-----QVLYSRPNRLLSGVP-LYKGDVPTQDKSAVTSL 6283

Query: 659  RE---QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI--LKWKTAIQTT 713
             +   QA  + S Q        K++ IH++   +K +D +SA    W+  ++ +  + T 
Sbjct: 6284 LDGLNQAFEEVSSQS----GGAKRQSIHLE---QKLYDGVSATS-TWLDDVEERLFVATA 6335

Query: 714  EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADE-LNQTGQILVEQMGKEGLPTEEIKNV 772
             + E     +T       + L K+ +E     D+  N   Q   E      +  + +  +
Sbjct: 6336 LLPE-----ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL 6390

Query: 773  LEKVSSEWKNVSQHLEDLERKIQ----LQEDINAYFKQLDELEKVIKTKEEWVKHTSISE 828
            L ++S     V+Q    ++ ++Q     Q D+   F  L + + +I  K   V    ++E
Sbjct: 6391 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAE 6450

Query: 829  SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQA 888
               +++   +D  +     +      IE+ R      + QPS  +            Y  
Sbjct: 6451 QI-EAIQQAEDGLKEFDAGI------IELKRRGDKLQVEQPSMQEL-----SKLQDMYDE 6498

Query: 889  VQEAVEDRQQHLENEL--KGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA 946
            +   +  R+  L   L  K Q    Y   L+ L D+L   + K      ++         
Sbjct: 6499 LMMIIGSRRSGLNQNLTLKSQ----YERALQDLADLLETGQEKMAGDQKII--------- 6545

Query: 947  LQEKKTLDEILENQKPALHKLAEE---TKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVL 1003
            +  K+ + ++L+  K     L      T+ L + +     +   Q   ++  + + +   
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 6605

Query: 1004 VSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFV 1063
              K    LE I  T    + D   + + ++ V+  +      + ++    R +D+ + + 
Sbjct: 6606 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENE---DRLIDRITLY- 6661

Query: 1064 NEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSES 1123
               + ++SSL    E +  L      G +  +     D ++QL +L +   +  +++S+ 
Sbjct: 6662 ---QHLKSSLN---EYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKE 6715

Query: 1124 QEKAANLKK-------DLAEMQEWMTQAEE--EYLERDFEYKSPEELESAVEEMKR---- 1170
              +   + K       + A++  W+  A++  E+  +      P+ELE   + +      
Sbjct: 6716 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEF 6774

Query: 1171 AKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEE 1230
            +KE   Q  ++  +L    +LL  K       L SEL+ +   +  L   I      L +
Sbjct: 6775 SKEVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQ 6833

Query: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQI 1290
            +    +   H +    +W++ +E  ++  E   + +       E L+       D     
Sbjct: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID--INC 6891

Query: 1291 RELGQTLIDGGILD----DIIS---------EKLEAFNSRYEDLSHLAESKQISLEKQLQ 1337
            ++L    ++  +L     D+ S         E+L A N  ++ L  L   K   LE  L+
Sbjct: 6892 KQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951

Query: 1338 VLRETDQMLQVLQESLGELDKQLTTY--LTDRIDAFQVPQEAQKIQAEISAHELTLEELR 1395
               E +  +Q L+      +K+L     + D+       ++ Q ++  I A E  +E++ 
Sbjct: 6952 SWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIE 7011

Query: 1396 RN------MRSQPLTSPESRTARG------------GSQMDVLQRKLREVSTKFQLFQKP 1437
            +N       + + ++S    T R             G    +L+  L + S+    F K 
Sbjct: 7012 QNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7071

Query: 1438 ANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIK 1497
             ++   +++ +  L   +     L+   V  D +Q   D   K  ++L +       ++K
Sbjct: 7072 NSY---LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7128

Query: 1498 TGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMK---KEAA 1554
                 V +  T+        L  + + +N+L  ++ E  Q  +   QL ++ K   K+ A
Sbjct: 7129 ECHPPVTETLTNT-------LKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7181

Query: 1555 SLSEWLSATETELVQKSTSEGLLGD-LDTEISWAKNVLKDLEKRKADLNTITESSAALQN 1613
            S  +       EL++ +T++ +  D + T I    ++LK L   K  L  + E    L+ 
Sbjct: 7182 STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 7241

Query: 1614 LIEGS--------EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHIS 1665
             ++ S        +  L + LC L     + +T       +L       E F  ++  + 
Sbjct: 7242 QVDASAASAIQSDQLSLSQHLCALEQALCKQQT-------SLQAGVLDYETFAKSLEALE 7294

Query: 1666 TWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGS----S 1721
             W+ +AE +L   +   +S    I +R+  EL    L+  ++    L  +N  G     +
Sbjct: 7295 AWIVEAEEILQGQDPSHSSDLSTIQERM-EELKGQMLKFSSMAPD-LDRLNELGYRLPLN 7352

Query: 1722 SRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPF--SDLEKLE 1779
             +E+   ++  LNR++  +S    + +    Q  L Q     E  ET + F     +KL 
Sbjct: 7353 DKEI--KRMQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLA 7409

Query: 1780 NDIE-NMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLL 1838
             +I  N    +E+         +M      +  ++  G+ +L Q   D++ E   L+L L
Sbjct: 7410 VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTL 7468

Query: 1839 LHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS----LNVP- 1893
            L  ++  +  I   Q++ G + S IR      +   ++ K L+ +  + +S    + +P 
Sbjct: 7469 LSNQWQGV--IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPL 7526

Query: 1894 ELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQL 1953
            +    ++++  F+E      K  L + G  I  +   +  ++   SG EA  ++  L ++
Sbjct: 7527 QQARTLFDEVQFKE------KVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAELAEI 7579

Query: 1954 NAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEK 2013
              KW   +    ++K      +++W +    + D  + +   ++ L  +  P    +L  
Sbjct: 7580 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSL-PDHHEELHA 7638

Query: 2014 ARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVK 2073
             ++  +ELE  + S       L+   D +   +S  D S L E++  L ++W+ +  ++ 
Sbjct: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698

Query: 2074 DRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVH 2132
             R+ ++     +   +  +  E+  WLT+ E  + +     + E +++L +D  +E+ + 
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758

Query: 2133 AEKLKWLNRTELEMLSDKSLSLPERDKISE---SLRTVNMTWNKICREVPTTLKECIQEP 2189
             E     N+ +L+ + ++        K SE    L  VN  W  +   +   +K+     
Sbjct: 7759 QE-----NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK----- 7808

Query: 2190 SSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQML 2249
              + +T +A                                LDK ++ L  WL  I+  L
Sbjct: 7809 --LKETLVAVQ-----------------------------QLDKNMSSLRTWLAHIESEL 7837

Query: 2250 KSNIVTVG-DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN--KASSSDMR-TA 2305
               IV    + EEI + ++  +  + D+E+    +  V  L + L +   A ++D    +
Sbjct: 7838 AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS 7897

Query: 2306 ITEKLERVKNQWDGTQHGVELRQQQLED-------MIIDSLQWDDHREETEELMRKYEAR 2358
            I +    +  +W         R+ ++E+        + D  +++D  + +E     + + 
Sbjct: 7898 IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER-TAAFPSS 7956

Query: 2359 LYILQQARRDPLTK----QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVK 2414
              ++    ++ L K    Q   ++ L Q        +   +   ++L  E  +D   ++K
Sbjct: 7957 SGVIYTVAKEELKKFEAFQRQVHECLTQ--------LELINKQYRRLARENRTDSACSLK 8008

Query: 2415 ETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASH 2474
            +        W NL++ +      L+      +      ++ L W+ E +  +  +   S 
Sbjct: 8009 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS- 8067

Query: 2475 RENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLD 2534
             E  +Q  I  ++LK   Q+I      HN I + I    Q + K+     +A +++  LD
Sbjct: 8068 -ECDVQAKI--KQLKAFQQEISLN---HNKIEQIIAQGEQLIEKS--EPLDAAIIEEELD 8119

Query: 2535 DMNQRWNDL-----KAKSASIRAHLEASAEKWNRLLMSLEEL-----IKWLNMKDEELKK 2584
            ++ +   ++     +     IR  L       +   + LE+      + W +   + L  
Sbjct: 8120 ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 8179

Query: 2585 QMP----------------IGGDVPA----LQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
              P                 G D PA    + L++DH   L R+L+       +A+ +A 
Sbjct: 8180 PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE-------SAMSRA- 8231

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
                             L S+ E   +++   +  A+      + E  E+   +T N  K
Sbjct: 8232 -----------------LPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIK 8274

Query: 2685 QVD---KALE-KLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFRE 2740
                   ALE ++R L  A+DD    +++ E++     P G  L  S + +++ +     
Sbjct: 8275 NTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8334

Query: 2741 EIAPI-NFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQ---VSVDDRLKQLQ 2796
             I  +   + K   +  S    ++LH +   +  + D   RW+LLQ   +S + R+KQ  
Sbjct: 8335 SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID---RWELLQAQALSKELRMKQNL 8391

Query: 2797 EAHRDF 2802
            +  + F
Sbjct: 8392 QKWQQF 8397



 Score =  141 bits (355), Expect = 1e-32
 Identities = 508/2716 (18%), Positives = 1033/2716 (38%), Gaps = 477/2716 (17%)

Query: 272  KYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDL---DSYQIALEEVLTWLLSA 328
            K  +E +E+ + + +  P        +E    + EV +DL   D  Q  ++EV     ++
Sbjct: 5305 KMAEEQKEKYLGLYTILP--------SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATS 5356

Query: 329  EDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEF 388
            ++  ++   ++ D+  +  +       +++    Q  +G  L   N  + +   + ++  
Sbjct: 5357 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFL 5416

Query: 389  EIQEQM---------TLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWL--- 434
            E   Q+          L     + +R ++ +R S+L+     L++  + L+ +  W+   
Sbjct: 5417 EQNGQLGKPLAKKIGKLTELHQQTIR-QAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5475

Query: 435  -TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGE 493
              L    I       L +     Q LLEE K + S+LEA   K+  LT +          
Sbjct: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--------- 5526

Query: 494  SATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALN 553
              T  +  Q+ +LG     + +  + R   LQ+     ++   E   L+A L + +  L 
Sbjct: 5527 -CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585

Query: 554  KVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSD 613
              +      +++LS    R  +L E   +K +   Q  ++ Q   ++ ++  AS  +   
Sbjct: 5586 SPEVGRLSLKEQLS---HRQHLLSEMESLKPKV--QAVQLCQSALRIPEDVVASLPLCHA 5640

Query: 614  SEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETV-----RVREQAITKKSK 668
            +  L +    L        N +  AV +    +   K L + +      + ++ +   + 
Sbjct: 5641 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI 5700

Query: 669  QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMK 728
            QEL       + QI    E  +K      ++ +  L  K  + T + K    +   +E++
Sbjct: 5701 QEL-------QAQISRHEELAQKIKGYQEQIAS--LNSKCKMLTMKAKHATMLLTVTEVE 5751

Query: 729  KKLKALEKEQRERIP-----------RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVS 777
               +  E    E +P            A   +     + E+ G+EG  +E       +  
Sbjct: 5752 GLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSP 5811

Query: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
            S   N             + +DI AY++ L    + ++T    + H S S S     P L
Sbjct: 5812 SPVANTD---------ASVNQDI-AYYQALS--AERLQTDAAKI-HPSTSASQEFYEPGL 5858

Query: 838  KDSCQRELTNLLGLHPKI-----EMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQ-E 891
            + S   +L +L      +     E  R    AL  Q    D +Q    S   + +A++ +
Sbjct: 5859 EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ----SISTKMEAIELK 5914

Query: 892  AVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKK 951
              E  +     E +     A ++ +  L+D +N+ ++     L   +  A   + L  + 
Sbjct: 5915 LSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 5974

Query: 952  TLDEILENQKPALHKLAEETKALEKNVHPDVE--------KLYKQEFDDVQGKWNKLKVL 1003
            TL  + E       K + + + LE+ ++  +E        + Y+ E D++       K  
Sbjct: 5975 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034

Query: 1004 VSKDLHLLEE-IALTLRAFEADSTVIEKWMDGV---------KDFLMKQQAAQGDDA-GL 1052
            +   L   +E + +  +  +  + ++E     V         ++ L++ +A   D+A  L
Sbjct: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094

Query: 1053 QRQLDQCSAFVNEIE--------TIESSLKNMKEIETNLRSGPVAGIK--------TWVQ 1096
              +L +    + E++         ++ + +  +E + +L +    G++        TW Q
Sbjct: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154

Query: 1097 TRLGDYQTQLEKLSKEIATQKSRLSE---------SQEKAANLKKDLAE-----MQEWMT 1142
             R    Q Q E L +E+A QKS L            Q  AA    D  E      QE   
Sbjct: 6155 QRQSSLQQQKE-LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGM 6213

Query: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKE------VRVKILKDNIKLLAAKV 1196
            + E+   E     K  E L       ++  ++VL++E       R   L   + L    V
Sbjct: 6214 EGEKSSAEDQMRMKW-ESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV 6272

Query: 1197 P----SGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTL 1252
            P    S    L   LN   E         + +   LE+      +L   +   +TWL+ +
Sbjct: 6273 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQ------KLYDGVSATSTWLDDV 6326

Query: 1253 EERM-KSTEVLPEKTDA-----------VNEALESLE-------SVLRHPADNRTQIRE- 1292
            EER+  +T +LPE+T+            + E  E ++              DNR  I + 
Sbjct: 6327 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDT 6386

Query: 1293 LGQTLIDGGILDDIISEKLEAFNSRYEDL-----------SHLAESKQISLEKQLQV--- 1338
            LG  L    +LD +++++      R + +           + LA++K I L+K   V   
Sbjct: 6387 LGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQ 6446

Query: 1339 -LRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEEL--- 1394
             + E  + +Q  ++ L E D  +   L  R D  QV Q + +   E+S  +   +EL   
Sbjct: 6447 PVAEQIEAIQQAEDGLKEFDAGIIE-LKRRGDKLQVEQPSMQ---ELSKLQDMYDELMMI 6502

Query: 1395 ---RRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLD-CKRV 1450
               RR+  +Q LT             D+L+    +++   ++        Q++LD  K  
Sbjct: 6503 IGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 6562

Query: 1451 LDGVKAELHVLDVKDVDPDVI--------QTHLD---KCMKLYKTLSEVKLEVETVIKTG 1499
              G+  E H++  + +   +I        Q H +   +   + K   +  +E+E +++T 
Sbjct: 6563 FQGL--ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW 6620

Query: 1500 RHIVQKQQ-------------------TDNPKGMDEQLTSLKVLYNDLGAQ-------VT 1533
             H+ + QQ                    +N   + +++T  + L + L          + 
Sbjct: 6621 SHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLD 6680

Query: 1534 EGKQ--------DLE-RASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEI 1584
            +GK+        DLE + +QL          +S+ L   ET L   +  +    DL   +
Sbjct: 6681 DGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6740

Query: 1585 SWAKN-----------VLKDLEKRKADLNTITE--------SSAALQNLIEGSEPILEER 1625
              AK+           V ++LE  +  LN   E        SS     L  G++ +  ++
Sbjct: 6741 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK 6800

Query: 1626 L--CVLNAGWSRVRTWTEDWCNTLMN--------HQNQLEIFDGN--VAHISTWLYQAEA 1673
            +    L +  SR+      W + L N        HQ Q++       ++ + +W+   E 
Sbjct: 6801 VDTATLRSELSRI---DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 6857

Query: 1674 LLDEIEK--------KPTSKQEEIVKRLVSELDDANLQVENVRDQALIL----MNARGSS 1721
            ++ + E         K   +  +  K    +++   L V+ V    L +    + ++ S 
Sbjct: 6858 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 6917

Query: 1722 SRELVEPKLAELNRNFEKVSQHIKSAKLLIAQ---------EPLYQCLVT-TETFETGVP 1771
              +  E +L  +N++++ + Q + + K+ + +         E   QCL T  ET E  + 
Sbjct: 6918 KTDFAE-QLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK 6975

Query: 1772 FSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEK 1831
                   +  ++N LK      +  D ++ +  +  ++E++ Q G  ++      NKKE 
Sbjct: 6976 QQHRIGDQASVQNALK------DCQDLEDLIKAKEKEVEKIEQNGLALI-----QNKKED 7024

Query: 1832 IRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLP-TDYLVEINKILLCMDDVELSL 1890
            +    +++ T     +        +GQL   ++S L   + + V  +KI   + +   SL
Sbjct: 7025 V--SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 7082

Query: 1891 NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTL 1950
            +   L T   E    Q D+L+N++D L+K    +         ++ E   P    + +TL
Sbjct: 7083 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 7142

Query: 1951 TQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLD 2010
             ++N +W+ +    +++       ++ W+++          + + E+   +      + D
Sbjct: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202

Query: 2011 LEKARIHQ-----QELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRW 2065
            +    +        +L  G+ + + S   L+  G+ + Q++  +  S ++     L+Q  
Sbjct: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262

Query: 2066 DAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDL 2125
             A+   +  +Q  L+        +   L+ +  W+ +AE  +Q +  +    +L  +++ 
Sbjct: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH-SSDLSTIQER 7321

Query: 2126 TQEMEVHAEKLKWLNRT-ELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKE 2184
             +E++   + LK+ +   +L+ L++    LP  DK  + ++ +N  W+ I          
Sbjct: 7322 MEELK--GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI---------- 7369

Query: 2185 CIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVL 2244
                 SS +  R +    +Q  +L           H+T        L+K  T + ++LV 
Sbjct: 7370 -----SSQTTERFS---KLQSFLL----------QHQTF-------LEKCETWM-EFLVQ 7403

Query: 2245 IDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRT 2304
             +Q L   I   G+ + + +     ++ +A++  R   L  +    Q L  +    D R 
Sbjct: 7404 TEQKLAVEI--SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDD-RD 7460

Query: 2305 AITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS--LQWDDHREETEELMRKYEARLYI- 2361
                KL  + NQW G      +R+ Q    IIDS   QW  +RE  E+L +      Y+ 
Sbjct: 7461 EFNLKLTLLSNQWQGV-----IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515

Query: 2362 ----------LQQARRDPLTKQISDNQILLQE--------------LGPGDGIVMAFDNV 2397
                      LQQAR      Q  +   L Q+              L    G   A    
Sbjct: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE 7575

Query: 2398 LQKLLEEYGSDDTR--NVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENF 2455
            L ++ E++ S   R    K+   +L   W   ++ IAD              S   L  F
Sbjct: 7576 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD--------------SLEKLRTF 7621

Query: 2456 LKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQK 2515
             K + ++      L D  H E    + +  +EL+  +     ++   + +        + 
Sbjct: 7622 KKKLSQS------LPD--HHEELHAEQMRCKELENAVGSWTDDLTQLSLL--------KD 7665

Query: 2516 MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWL 2575
             + A  ++++ ++L  R++ + ++W +L  + +  R  +     +W       +EL +WL
Sbjct: 7666 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWL 7725

Query: 2576 NMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAP 2635
               + ++ +     GD+    L  +  + L+++ +E+                   I   
Sbjct: 7726 TQMESKVSQ----NGDI----LIEEMIEKLKKDYQEE-------------------IAIA 7758

Query: 2636 EEPRRNLQSKTELTPEERAQKIAKAMRK-QSSEVKEKWESLNAVTSNWQKQVD---KALE 2691
            +E +  LQ        +  +++AKA  + ++SE++ K   L  V   WQ  +D     ++
Sbjct: 7759 QENKIQLQ--------QMGERLAKASHESKASEIEYK---LGKVNDRWQHLLDLIAARVK 7807

Query: 2692 KLRDLQGAMDDLDADM 2707
            KL++   A+  LD +M
Sbjct: 7808 KLKETLVAVQQLDKNM 7823



 Score =  132 bits (332), Expect = 6e-30
 Identities = 481/2679 (17%), Positives = 1045/2679 (39%), Gaps = 420/2679 (15%)

Query: 296  PRAETPSTVTEVDMDLDSYQIALEE-------VLTWLLSAEDTFQEQDDISDDVEEVKDQ 348
            P+AE  + +  +  D  +YQ  L E       V+  L   E  FQ+ D+     EE K  
Sbjct: 3572 PQAEDRA-LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKK-- 3628

Query: 349  FATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVES 408
               HE    E+TA++  V  V     +++ +  ++      +  Q T L +R++AL ++ 
Sbjct: 3629 --WHE----EVTAYRDEVEEVGARAQEILDESHVNSR----MGCQATQLTSRYQALLLQV 3678

Query: 409  MDRQSRLHDVLMELQKKQ--LQQLSAWLTLTEE-------RIQKMETCPLDDDVKSLQKL 459
            +++   L + +  L++ +  L   S W   T +       +I K++T  +   +K+L+ L
Sbjct: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVL 3738

Query: 460  LEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEE 519
            L++ +   S L++ + K       V  ++E   E     + D +++L E  + V     +
Sbjct: 3739 LKDMEKGHSLLKSAREKGE---RAVKYLEEGEAERLRKEIHDHMEQLKELTSTV----RK 3791

Query: 520  RWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKED 579
                L++   L +E  ++   L  W+ E +E L+  +     +  E    + +   L++ 
Sbjct: 3792 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKM-ELYEKKAQLSKYKSLQQT 3850

Query: 580  MEMKRQTLDQLSEIGQDVGQLLDNSKASKKIN---SDSEELTQRWDSLVQRLEDSSNQVT 636
            +     ++  + E G+ + +L+ +     KI+   SD ++L     ++++ +    +++ 
Sbjct: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910

Query: 637  QAVAK----LGM-SQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKK 691
                K    +G  +   Q  L + V    Q  TK S   +        ++++  +E + +
Sbjct: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQG-TKDSYSAICSTA----QRMYQSLEHELQ 3965

Query: 692  FDAISAELLNWILKWKTAIQTT---EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADEL 748
                  + L     W +A+Q       +  +   +  +  K  +AL+++ R  +     +
Sbjct: 3966 KHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSM 4025

Query: 749  NQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLD 808
                   V+   K+   TE+    +E+   + +N++Q  E+++    L+ ++  Y +  D
Sbjct: 4026 CDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKH---LKSELWIYLQDAD 4079

Query: 809  ELEKVIKTKEEWVKHTSISESSRQSLPS-LKDSCQRELTNLLGLHPKIEMARASCSALMS 867
            +  + +K +     H+ +  +  Q++ S +KD  ++  +    ++  IE      + L  
Sbjct: 4080 QQLQNMKRR-----HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKV----NKLTK 4130

Query: 868  QPSAPDFVQRGF--DSFLGRYQAVQEAVEDRQQHLENELKGQPG----HAYLETLKTLKD 921
            +  +P+  +     D +L   +        R++ L+              +LE   T  D
Sbjct: 4131 KEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWD 4190

Query: 922  VLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPD 981
             L  S+  A+ +   L  L K+  ALQE+K   E L++QK          + + ++++ D
Sbjct: 4191 NLARSD--AESTAVHLEALKKLALALQERKYAIEDLKDQK----------QKMIEHLNLD 4238

Query: 982  VEKLYKQEFDDVQGKWNKLKVLVSKDLHL----LEEIALTLRAFEADSTVIEKWMDGVKD 1037
             ++L K++   ++ +W +L+ L+ + + +    LEE+ +    F+      E+    + +
Sbjct: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298

Query: 1038 FLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQT 1097
             L  +Q+   D A  Q  L    A  +E+E  +  LK++ +    + +      +  +Q 
Sbjct: 4299 AL--KQSPPPDMA--QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4354

Query: 1098 RLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKS 1157
             L D Q+ +  LS  +  ++  L+++  +       + +    + Q E + + R+     
Sbjct: 4355 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414

Query: 1158 PEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLL 1217
            P+++   V+  K A       +  +K  ++ +  L A+    G+EL  E   V E  +  
Sbjct: 4415 PDDVSKQVKTCKSA-------QASLKTYQNEVTGLWAQ----GRELMKE---VTEQEK-- 4458

Query: 1218 CNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLE 1277
             + + GK   L+ V+   ++   +       L  LE+ + S +   E  D     L+  +
Sbjct: 4459 -SEVLGKLQELQSVYDSVLQKCSHR------LQELEKNLVSRKHFKEDFDKACHWLKQAD 4511

Query: 1278 SVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQ 1337
             V     +   +  EL   L            K +    +  +  +L  + Q + +  L 
Sbjct: 4512 IVTFPEINLMNESSELHTQLA-----------KYQNILEQSPEYENLLLTLQRTGQTILP 4560

Query: 1338 VLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
             L E D     L E L  L +Q    +    D F   QEA   + E +            
Sbjct: 4561 SLNEVDH--SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYA------------ 4606

Query: 1398 MRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAE 1457
                             S +++  + L E+  +F    K                 V  +
Sbjct: 4607 -----------------SLIELTTQSLSELEAQFLRMSK-----------------VPTD 4632

Query: 1458 LHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQ 1517
            L V +   +  D  +  LD+   L + + E+  + E    TG    Q  Q D       +
Sbjct: 4633 LAVEEALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRSTG----QPWQPD-------K 4680

Query: 1518 LTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLL 1577
            +  L  LY+ L  Q  +    LE  +   ++ +K    L   L + + E  Q   +E  L
Sbjct: 4681 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE--QSKVNEETL 4738

Query: 1578 GDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWS-RV 1636
               + ++    ++   L+     L  +T     L++L    +P+  E+       W   +
Sbjct: 4739 -PAEEKLKMYHSLAGSLQDSGIVLKRVT---IHLEDLAPHLDPLAYEKARHQIQSWQGEL 4794

Query: 1637 RTWTEDWCNTLMNHQNQLEI---FDGNVAHISTWLYQAEALLDE---IEKKPTSKQEEIV 1690
            +  T     T+   ++++     F   ++    WL + +A L     ++      QEEI 
Sbjct: 4795 KLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIR 4854

Query: 1691 K-RLVSELDDANLQVENVRDQALILMNARGSSSRELV----EPKLAELNRNFEKVSQHIK 1745
            K ++  E   ++L++ N           + + ++EL+    E  LAEL+     + + ++
Sbjct: 4855 KIQIHQEEVQSSLRIMNALSHK---EKEKFTKAKELISADLEHSLAELSELDGDIQEALR 4911

Query: 1746 SAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHL--ESSDEDEKMD 1803
            + +  +  E   QC    + F+    + +      D + +L+     L  ES++E+ K  
Sbjct: 4912 TRQATLT-EIYSQCQRYYQVFQAANDWLE------DAQELLQLAGNGLDVESAEENLKSH 4964

Query: 1804 EESAQIEEVLQRGEEMLHQPM-------EDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKM 1856
             E    E+      E LH  +       +   KE +            K+ ++ ++ ++M
Sbjct: 4965 MEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLE----------QKVASLELRSQRM 5014

Query: 1857 GQLASGIRSSLLPT------DYLVEINKILLCMDDVELSLN-VPELNTAIYEDFSFQEDS 1909
             +  SG +  LL        DY     +++  M+D E  L+    L T+   +   +   
Sbjct: 5015 SR-DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE 5073

Query: 1910 LKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQ--IRDTLTQLNAKWDRINRMYSDR 1967
             K +   ++   E+I  + EK     LE +G +A +  +  ++T +  +W R+  +  D+
Sbjct: 5074 HKALVSVVNSFHEKIVALEEKASQ--LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5131

Query: 1968 KGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSL----------DLEKARIH 2017
            +   + A++EW  F+  +   T+ I + ++ L  + A   S           D     + 
Sbjct: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5191

Query: 2018 QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQP 2077
            QQ+  +G+   Q     L+   DG     +  +   L +++  +  R   +  +VK    
Sbjct: 5192 QQQSALGMLRQQ----TLSMLQDGAAP--TPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245

Query: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLK 2137
             +K E K       Q++ + CW+ + +  +    T E+   L+EL+ L  E   H + ++
Sbjct: 5246 LVKQELKDREMVETQINSVKCWVQETKEYL-GNPTIEIDAQLEELQILLTEATNHRQNIE 5304

Query: 2138 WLNRTELE---------------MLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTL 2182
             +   + E                L++ +L L  RD+I + ++ V  +     +E+   +
Sbjct: 5305 KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQS-KATSQELSRQI 5363

Query: 2183 KECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWL 2242
            ++  ++ +++             +  + + +D  VQ+ +T +  +  +LD   ++L +  
Sbjct: 5364 QKLAKDLTTI-------------LTKLKAKTDNVVQA-KTDQKVLGEELDGCNSKLMELD 5409

Query: 2243 VLIDQMLKSN-------IVTVGDVEEINK--------TVSRMKITKADLEQRHPQLDYVF 2287
              + + L+ N          +G + E+++         +S++    + LE+ +  L+ + 
Sbjct: 5410 AAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELIL 5469

Query: 2288 TLAQNLKNKA-------SSSDMR--------------------TAITEKLERVKNQW--- 2317
               +  K  A       S+S +R                     A+TEKL+ + + +   
Sbjct: 5470 KWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTE 5529

Query: 2318 DGTQHGVEL--RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQA---RRDPLTK 2372
              +Q   EL    ++L  MI   LQ   + ++  + M+K+EA L  LQ A    +  LT 
Sbjct: 5530 KMSQQVAELGRETEELRQMIKIRLQ---NLQDAAKDMKKFEAELKKLQAALEQAQATLTS 5586

Query: 2373 QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKE---TTEYLKTSWINLKQ 2429
                   L ++L     ++   +++  K+           + E    +  L  + + L++
Sbjct: 5587 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE 5646

Query: 2430 SIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELK 2489
              +  Q+    +   +QA+    E +    ++    +  L++ +HRE  ++D  +A    
Sbjct: 5647 EASRLQHTAIQQCNIMQAAVVQYEQY----EQEMKHLQQLIEGAHRE--IEDKPVA---T 5697

Query: 2490 QQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSAS 2549
              +Q++QA+I  H ++ + I G ++++       +  TM               KAK A+
Sbjct: 5698 SNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTM---------------KAKHAT 5742

Query: 2550 IRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPA-LQLQYDHCKALRRE 2608
            +              +  +E L +     D EL   +P     P+ + +    C  L   
Sbjct: 5743 MLL-----------TVTEVEGLAEGTEDLDGEL---LPTPSAHPSVVMMTAGRCHTLLSP 5788

Query: 2609 LKEKE------------------YSVLN---AVDQARVFLADQPIEAPEEPRRNLQSKTE 2647
            + E+                     V N   +V+Q   +      E  +     +   T 
Sbjct: 5789 VTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5848

Query: 2648 LTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDA-- 2705
             + E     +  +   +  +++  WE+L  V S  Q+ + +ALE+ +  Q ++  +    
Sbjct: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908

Query: 2706 ---DMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPL 2762
               ++K +ES   G  P   +     Q  +++I+  ++EI  +   +    +L S+    
Sbjct: 5909 EAIELKLSESPEPGRSPESQMA--EHQALMDEILMLQDEINELQSSL--AEELVSESCEA 5964

Query: 2763 DLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRD 2801
            D    L +   L  L  R   +++    + + L+E   D
Sbjct: 5965 DPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003



 Score =  124 bits (311), Expect = 2e-27
 Identities = 465/2705 (17%), Positives = 980/2705 (36%), Gaps = 438/2705 (16%)

Query: 318  LEEVLTWLLSAEDTFQEQD-DISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQL 376
            L   LTWL   E      + DIS D  +V+ +    +A   E+ +  S    +LQ    L
Sbjct: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730

Query: 377  ITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWL 434
             +  +  D +  ++  +   L+ RW  L      R + L  V+ E Q+  + L   S W+
Sbjct: 1731 FSVASKDDVKMMKLHLEQ--LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI 1788

Query: 435  TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLT-HMVVIVD----- 488
             L    +Q      + D     Q  L  HK   +++E+++ ++ SL  H+  +       
Sbjct: 1789 KLFLSELQTTSEISIMDH----QVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAE 1844

Query: 489  -----ENSGESATAILEDQLQKLGERWTAVC-------------------RWTEERWNRL 524
                 +   E    + E+  Q +  R  A+                    R T E  N +
Sbjct: 1845 DLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSM 1904

Query: 525  Q--EINILWQEL---LEEQCLLKAWLTEKEEALNKVQ-----------TSNFKDQKELSV 568
               E +++ ++L   L+    L++     +  L+K Q           TS      +L  
Sbjct: 1905 NKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG 1964

Query: 569  SVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQR- 627
             V R+  L    + +   L  L +  QD  + L  S    +  +D E L +     +Q+ 
Sbjct: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024

Query: 628  ------LEDSSNQVTQAVAKLG--MSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKK 679
                  LED  N     +  L     QI QKD+     V  +         L       K
Sbjct: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREI------NRLEVTWDDTK 2078

Query: 680  RQIHVD-------IEAKKKFDAISAELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKL 731
            R IH +       I+  +++  + + +   +    + I T T IK+    +D      K 
Sbjct: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKD---QEDLKWAFSKH 2135

Query: 732  KALEKEQRERIPRADELNQTGQILVEQMGK-EGLPTEEIKNVLEKVSSEWKNVSQHLEDL 790
            +  + +   +    D     G+ L+ ++ K        +K  +E    +W +VS+ LE+ 
Sbjct: 2136 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEEN 2195

Query: 791  ERKIQLQEDI-NAYFKQLDELE----KVIKTKEEWVKHTSISESSRQSLPSLKDSCQREL 845
              ++++   I +      DE+E      +    E + +      + + L   +   + + 
Sbjct: 2196 MDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKA 2255

Query: 846  TNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELK 905
              L  LH K+   +     L + P                 Q ++  +  + +H +   +
Sbjct: 2256 LRLEELHSKVNDLKELTKNLETPPDL---------------QFIEADLMQKLEHAKEITE 2300

Query: 906  GQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEK------------ALQEKKTL 953
               G        TLKD    S    +   ++     KVE+            AL++ K +
Sbjct: 2301 VAKG--------TLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDI 2352

Query: 954  DEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEE 1013
             + L++Q+  +    E   +L +  H    +   +    +  K   +  L SK    L+E
Sbjct: 2353 QKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQE 2412

Query: 1014 IALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSL 1073
                 + F       ++W  G K    +     GD   L+ +L      ++ +   +S L
Sbjct: 2413 SLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470

Query: 1074 KNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKD 1133
              + +    L +     I + +Q ++     + +   K+    K  L +   +  + +  
Sbjct: 2471 DAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQ 2530

Query: 1134 LAEMQEWMTQAEEEYLERDFEYKSPE--ELESAVEEMKRAKEDVLQKEVRVKILKDNIKL 1191
              ++  W+ + EE +   +         E ++ V +++    ++L     +  L    +L
Sbjct: 2531 HRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL 2590

Query: 1192 LAAKVPSGGQE--LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETT-- 1247
            L+ +    GQE  L S+L   L ++Q L         T E++ SC + L  +  LE    
Sbjct: 2591 LSEEGHGAGQEGRLCSQL---LTSHQNLLRM------TKEKLRSCQVALQEHEALEEALQ 2641

Query: 1248 ----WLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL---GQTLIDG 1300
                W+  +++R+   E      D + + L  ++ +L    +   ++      G+  +  
Sbjct: 2642 SMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRS 2701

Query: 1301 GILDD--IISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDK 1358
               +   +I  +LE     + D+   +   Q +LE  +    +  +    L++ +  +D+
Sbjct: 2702 SNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQ 2761

Query: 1359 QLTTYLTDR---IDAFQVPQEAQKIQAEISAHELTLEELRRNMR---------SQPLTSP 1406
            ++   L  +    + F +    Q I +E   H   L  L    R         S   T+ 
Sbjct: 2762 KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ 2821

Query: 1407 ESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDV 1466
            E    +    M V + K+R+V    ++ +    +   + +    L   K ELH       
Sbjct: 2822 EELKTQFNDIMTVAKEKMRKVE---EIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG 2878

Query: 1467 DPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYN 1526
            D    Q  L K  +L  +       +  V      + Q       + M  ++ +L+  + 
Sbjct: 2879 DSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWK 2938

Query: 1527 DLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISW 1586
                 V + +  LE    L  +M       S  ++  E  L Q S    LL       +W
Sbjct: 2939 QWEDSVFQTQSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFS---ALLK------TW 2986

Query: 1587 AKNVLKDLEKRKADLNTIT--ESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWC 1644
            A+  L  LE +  D   +        + + ++ +EP  E+                +   
Sbjct: 2987 AQQ-LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED---------------LKSQL 3030

Query: 1645 NTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQV 1704
            N L      L  + G V+ +   + +   L  +  K   +K++ + +R            
Sbjct: 3031 NELCRFSRDLSTYSGKVSGL---IKEYNCLCLQASKGCQNKEQILQQRFRKAF------- 3080

Query: 1705 ENVRDQALILMNARGSSSRELVEPK-LAELNRNFEKVSQHIKSAK-------LLIAQEPL 1756
               RD    L+NA+ ++++    P+ ++E++ + +K+ + +  ++       +++++  L
Sbjct: 3081 ---RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGEL 3137

Query: 1757 YQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRG 1816
               L+T E  + G+  + +   + D +N       H     ++  ++    Q+++     
Sbjct: 3138 LSTLLTKEKAK-GIQ-AKVTAAKEDWKNF------HSNLHQKESALENLKIQMKDF---- 3185

Query: 1817 EEMLHQPMED--NKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLV 1874
             E+  +P++D  +K EK      ++H   N++  +P ++R+  +L S             
Sbjct: 3186 -EVSAEPIQDWLSKTEK------MVHESSNRLYDLPAKRREQQKLQS------------- 3225

Query: 1875 EINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV 1934
                                    + E+    E  L  +K++  +L E  A         
Sbjct: 3226 ------------------------VLEEIHCYEPQLNRLKEKAQQLWEGQAA-------- 3253

Query: 1935 ILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITE 1994
                    +   R  ++QL++++  ++ +  ++    DR + E  QF   + +L  W+T+
Sbjct: 3254 --------SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTD 3305

Query: 1995 AEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQP-SFAALNRTGDGIVQKLSQADGSF 2053
            A  +L   C P     +  +R  + E  + +   +      +   G+ ++Q  S      
Sbjct: 3306 AIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3365

Query: 2054 LKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT 2113
            ++++L  +   W ++++     + +L+G   +   Y+  + +   W+   E      +  
Sbjct: 3366 IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSME-----ANLN 3420

Query: 2114 ELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNK 2173
            E      ELRD T  +     K K LN    E+LS  SL           L T+ +    
Sbjct: 3421 ESERQHAELRDKTTML----GKAKLLNE---EVLSYSSL-----------LETIEVKGAG 3462

Query: 2174 ICREVPTTLK-ECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLD 2232
            +     T L+ + +QE     Q R               A +   +S +   + +  +  
Sbjct: 3463 MTEHYVTQLELQDLQERYRAIQER---------------AKEAVTKSEKL--VRLHQEYQ 3505

Query: 2233 KTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQN 2292
            + +     WL    + L    V  GD      T+  ++  +    +    L+ V     +
Sbjct: 3506 RDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVL----H 3561

Query: 2293 LKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELM 2352
             +     S +  A    LE ++  W   QH +   + Q  +++      +   ++ +E +
Sbjct: 3562 TREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWL 3621

Query: 2353 RKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRN 2412
            +  E + +           ++++  +  ++E+G             Q++L+E   +    
Sbjct: 3622 KTAEEKKW----------HEEVTAYRDEVEEVGAR----------AQEILDESHVNSRMG 3661

Query: 2413 VKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDA 2472
             + T   L + +  L   + ++   LE E ++++ S   L ++  W     T  N    A
Sbjct: 3662 CQAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWY--GSTHKNFKNVA 3717

Query: 2473 SHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHR 2532
            +  +    D+++  +  + ++ +  +++  + + KS     ++ VK L   E   + +  
Sbjct: 3718 TKIDKV--DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEI 3775

Query: 2533 LDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDV 2592
             D M Q    LK  ++++R           +  M+LE        K   L K+       
Sbjct: 3776 HDHMEQ----LKELTSTVR-----------KEHMTLE--------KGLHLAKEFS----- 3807

Query: 2593 PALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNL-QSKTELTPE 2651
                   D CKAL + + E +                + +  PEEP+  L + K +L+  
Sbjct: 3808 -------DKCKALTQWIAEYQ----------------EILHVPEEPKMELYEKKAQLSKY 3844

Query: 2652 ERAQKIAKAMRKQSSEVKEKWESLNAVTSN--WQKQVDKALEKLRDLQGAMDDLDADMKE 2709
            +  Q+   +       V+EK E+L  +  +   + ++D+     +DL      +  ++  
Sbjct: 3845 KSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAG 3904

Query: 2710 AESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLK 2769
             E   N  +  GD LI    DH++  +        ++  ++   D  S +          
Sbjct: 3905 FEDRLNNLQMKGDTLIGQCADHLQAKLK-----QNVHAHLQGTKDSYSAICSTAQRMYQS 3959

Query: 2770 MSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPY 2829
            +  +L           VS  D L+Q Q     +  + Q  L  S Q P  R+ +  +V +
Sbjct: 3960 LEHELQK--------HVSRQDTLQQCQA----WLSAVQPDLEPSPQPPLSRAEAIKQVKH 4007

Query: 2830 YINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEI 2889
            +   Q Q   +      +L  S+ DL+N   S   TA  I++ ++ +   L++     + 
Sbjct: 4008 FRALQEQARTY-----LDLLCSMCDLSNA--SVKTTAKDIQQTEQTIEQKLVQAQNLTQG 4060

Query: 2890 FKQHK 2894
            +++ K
Sbjct: 4061 WEEIK 4065



 Score =  122 bits (306), Expect = 6e-27
 Identities = 496/2780 (17%), Positives = 1038/2780 (37%), Gaps = 397/2780 (14%)

Query: 310  DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVE---EVKDQFATHEAFMMELTAHQSSV 366
            D   Y+  ++  L  L+S     QEQ +   D E   E +     H+     ++A +  V
Sbjct: 1240 DCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDV 1299

Query: 367  GSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM------ 420
               +    Q   +G L D    E+++  + L+         S +RQ R   V +      
Sbjct: 1300 QQQIAQAQQ--GEGGLPDRGHEELRKLESTLDGL-----ERSRERQERRIQVTLRKWERF 1352

Query: 421  ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL 480
            E  K+ + +       + ER     +      ++SL   LE+ K      E+  V+  +L
Sbjct: 1353 ETNKETVVRYLFQTGSSHERFLSFSS------LESLSSELEQTKEFSKRTESIAVQAENL 1406

Query: 481  THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540
                  +    G     +L+ Q + + E+   +    EE    ++ +   W         
Sbjct: 1407 VKEASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1464

Query: 541  LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600
            L  W+TEKE+ LN ++TS+      + + + ++ +  +++E K  ++  L E  Q   Q 
Sbjct: 1465 LSVWITEKEKELNALETSS----SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQF 1520

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660
            +   ++++       +LTQ     ++R  +   +  Q +    +  + Q+   E    + 
Sbjct: 1521 VTTGESARI----KAKLTQ-----IRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1571

Query: 661  QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEI-KEYM 719
            Q    + + +L  P                            I    +A +T ++ +E+M
Sbjct: 1572 QQSVSEFEDKLAVP----------------------------IKICSSATETYKVLQEHM 1603

Query: 720  KM-QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSS 778
             + Q    +   + A     R+ + R D   Q    L +Q        +E +  LE + +
Sbjct: 1604 DLCQALESLSSAITAFSASARKVVNR-DSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662

Query: 779  EWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS-ESSRQSLPSL 837
             W+             +L+++++++   L+  E    + E  +    +  E   Q + +L
Sbjct: 1663 HWQ-------------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQAL 1709

Query: 838  KDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQ 897
                Q E+ +    + K+   + S  ++ S+      ++   +    R++ + + +  R 
Sbjct: 1710 ----QNEVVSQASFYSKLLQLKESLFSVASKDDVK-MMKLHLEQLDERWRDLPQIINKRI 1764

Query: 898  QHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI- 956
              L++ +     H   + L                   +L+    ++  L E +T  EI 
Sbjct: 1765 NFLQSVVAE---HQQFDEL-------------------LLSFSVWIKLFLSELQTTSEIS 1802

Query: 957  LENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV-SKDLHLLEEIA 1015
            + + + AL +  +    +E           K E   +QG   KL  L  ++DLHLL+  A
Sbjct: 1803 IMDHQVALTRHKDHAAEVESK---------KGELQSLQGHLAKLGSLGRAEDLHLLQGKA 1853

Query: 1016 LT-LRAFEADSTVIEKW---MDGVKDFLMKQQAAQGDDAGLQRQLDQCSAF-VNEIETIE 1070
                + FE  S V+E+    +  + +FL    +  G    L++ ++  ++   NE + IE
Sbjct: 1854 EDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIE 1913

Query: 1071 SSLKNMKEIETNLRSGPVA--GI--KTWVQTRLGDYQTQL------EKLSKEIATQKSRL 1120
              L +  +    L S  V+  GI  K     ++G  + +       ++L  E+   ++ L
Sbjct: 1914 KDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL 1973

Query: 1121 SESQEKA---ANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA----KE 1173
               Q +A   A LKK   + +E + ++ E+  ER  + +  E    A+++  R     ++
Sbjct: 1974 GTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLED 2033

Query: 1174 DVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELN---VVLENYQLLCNRIRGKCHTLEE 1230
            ++   E  +  LKD  K +A K  +   E+  E+N   V  ++ + L +  +G+C  L +
Sbjct: 2034 ELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLID 2093

Query: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL-------ESLESVLRHP 1283
            +      +  Y +L++     LE    S+ ++   T    E L       E+ ++ + + 
Sbjct: 2094 L------MREYQNLKSAVSKVLENA--SSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2145

Query: 1284 ADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETD 1343
              +       G+ L+           +L+  +S   D S +    + +++K L V  + +
Sbjct: 2146 QKDLDNFTSKGKHLLS----------ELKKIHS--SDFSLVKTDMESTVDKWLDVSEKLE 2193

Query: 1344 QMLQVLQESLGELDKQLTTYLTDRIDAFQ---VPQEAQKIQAEISAHELTLEELRRNMRS 1400
            + +  L+ SL   D  L+T   D I+ +    VPQ A+ I + +  H L  EEL +   S
Sbjct: 2194 ENMDRLRVSLSIWDDVLST--RDEIEGWSNNCVPQMAENI-SNLDNH-LRAEELLKEFES 2249

Query: 1401 QPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHV 1460
            + + +   R     S+++ L+   + + T   L    A+  Q++   K + +  K  L  
Sbjct: 2250 E-VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKD 2308

Query: 1461 LDVKDVDPDV----IQTHLDKCMK-LYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMD 1515
               +    +     I T   K  + L         E    +K  +  +Q QQ+ N     
Sbjct: 2309 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQS-NISSTQ 2367

Query: 1516 EQLTSLKVLYND-----LGAQVTEGKQDLERASQLARKMK------------KEAASLSE 1558
            E L SL   Y+      LG  +T   +  E  SQL  K +            +      E
Sbjct: 2368 ENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQE 2427

Query: 1559 WLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQ-NLIEG 1617
            W    +    + S   G    L+ ++   +N+L  +   ++ L+ +T+    L  +L + 
Sbjct: 2428 WFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQ 2487

Query: 1618 SEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEAL--- 1674
                ++E++   N  +             L +  ++L  F+     ++ W+++ E     
Sbjct: 2488 IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT 2547

Query: 1675 --LDEIEKKPTSKQEEI--VKRLVSELDDANLQVENVRDQALILMN-ARGSSSRELVEPK 1729
              L E ++    K+ E+  V+  + EL  A   ++ +  +  +L     G+     +  +
Sbjct: 2548 ENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQ 2607

Query: 1730 LAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENM---L 1786
            L   ++N            L + +E L  C V  +  E          LE  +++M   +
Sbjct: 2608 LLTSHQNL-----------LRMTKEKLRSCQVALQEHEA---------LEEALQSMWFWV 2647

Query: 1787 KFVEKHLESSDED----EKMDEESAQIEEVLQ---RGEEMLH-------QPMEDNKKEKI 1832
            K ++  L  ++      + +++  +QI+++L     GE  L+       Q +  + KE  
Sbjct: 2648 KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2707

Query: 1833 RLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLP--TDYLVEINKILLCMDDVELSL 1890
            R+    + T+   +K +          A     S++    DY+   N++   M+ V+  +
Sbjct: 2708 RV----IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763

Query: 1891 NVP-ELNTAIYEDFSFQEDSLKNIKDQ-------LDKLGEQIAVIHEKQPDVILEASGPE 1942
              P +    + E F    D L++I  +       L +L  +   ++EK  D   + +  E
Sbjct: 2764 EHPLQPQPGLKEKFVLL-DHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE 2822

Query: 1943 AI--QIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLV 2000
             +  Q  D +T    K  ++  +  D     D   E     H    +L +W     ++  
Sbjct: 2823 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW----SDMSG 2878

Query: 2001 DTCAPGGSLDLEKARIHQQELEVGISSHQPSFAA---LNRTGDGIV-----QKLSQADGS 2052
            D+ A    L   K  I  +E+     S   S A     N T  G        +  +AD  
Sbjct: 2879 DSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWK 2938

Query: 2053 FLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEII-CW---LTKAEHAMQ 2108
              ++ +       + +V+++   +    G+  Q+ +   Q   ++  W   LT  E    
Sbjct: 2939 QWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNT 2998

Query: 2109 KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERD-KISESLRTV 2167
                 E     QE+ D  Q+ E   E LK    ++L  L   S  L     K+S  ++  
Sbjct: 2999 DEEIVECWHKGQEILDALQKAEPRTEDLK----SQLNELCRFSRDLSTYSGKVSGLIKE- 3053

Query: 2168 NMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISI 2227
               +N +C +     K C  +   + Q    A  + Q+ ++ +  +              
Sbjct: 3054 ---YNCLCLQAS---KGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKC---------- 3097

Query: 2228 PADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVF 2287
              D+ + I+E++  L  I + L  +        E  +    M ++K +L         + 
Sbjct: 3098 -FDIPQNISEVSTSLQKIQEFLSES--------ENGQHKLNMMLSKGEL---------LS 3139

Query: 2288 TLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREE 2347
            TL    K K   + + TA  E  +   +     +  +E  + Q++D  + +    D   +
Sbjct: 3140 TLLTKEKAKGIQAKV-TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3198

Query: 2348 TEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGS 2407
            TE+++ +   RLY L   RR+         Q +L+E+   +  +       Q+L E  G 
Sbjct: 3199 TEKMVHESSNRLYDLPAKRREQ-----QKLQSVLEEIHCYEPQLNRLKEKAQQLWE--GQ 3251

Query: 2408 DDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVN 2467
              +++ +     L + ++ L     ++ + L+     + A        +K +Q+  T   
Sbjct: 3252 AASKSFRHRVSQLSSQYLALSNLTKEKVSRLDR----IVAEHNQFSLGIKELQDWMTDAI 3307

Query: 2468 VLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEAT 2527
             ++D+     + +  + +R LK +       +    +I   +   R + V    + E   
Sbjct: 3308 HMLDSYCHPTSDKSVLDSRTLKLEAL---LSVKQEKEIQMKMIVTRGESVLQNTSPEGIP 3364

Query: 2528 MLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMP 2587
             +Q +L  +   W  L +     ++ LE +  KW      + +   W++  +  L +   
Sbjct: 3365 TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESER 3424

Query: 2588 IGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTE 2647
               ++          K L  E+     S+L  ++     + +  +   E   ++LQ +  
Sbjct: 3425 QHAELRDKTTMLGKAKLLNEEVLSYS-SLLETIEVKGAGMTEHYVTQLE--LQDLQERYR 3481

Query: 2648 LTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADM 2707
               E   + + K+  ++   + ++++        W  Q  + L++   L+G     +  +
Sbjct: 3482 AIQERAKEAVTKS--EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTL 3539

Query: 2708 KEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPS 2767
            ++ + ++      G  L++S       ++  RE++ P                     P 
Sbjct: 3540 RDLQELQVHCAE-GQALLNS-------VLHTREDVIPSGI------------------PQ 3573

Query: 2768 LKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKV 2827
             +  R L+ L   W+  Q  + +   Q            Q F        W ++    K 
Sbjct: 3574 AE-DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVD---EWLKTAEEKKW 3629

Query: 2828 PYYINHQTQTTCWDH-PKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTT 2886
                 H+  T   D   ++    Q + D ++V       A ++    +AL L +LE    
Sbjct: 3630 -----HEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKF 3684

Query: 2887 NEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTG 2946
             E          +++ S+ +  + L++  D     HK+  NV   +D          DT 
Sbjct: 3685 LE----------EEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK--------VDTV 3726

Query: 2947 RTGKIRVQSLKIGLMSLSKG 2966
              GK ++++L++ L  + KG
Sbjct: 3727 MMGK-KLKTLEVLLKDMEKG 3745



 Score =  114 bits (286), Expect = 1e-24
 Identities = 483/2746 (17%), Positives = 1047/2746 (38%), Gaps = 487/2746 (17%)

Query: 271  RKYKKECEEEAINIQSTAPEEEH---ESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLS 327
            ++ ++E  E+   ++S A   E    +   AET     E   D+ S ++ +E   +   S
Sbjct: 6164 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-DVLSQELGMEGEKS---S 6219

Query: 328  AEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLIT-----QGTL 382
            AED  + +       E +  +F+T +  +  +   Q     +    N+L++     +G +
Sbjct: 6220 AEDQMRMK------WESLHQEFSTKQKLLQNVL-EQEQEQVLYSRPNRLLSGVPLYKGDV 6272

Query: 383  SDEEEFEIQEQMTLLNARWEALRVES--MDRQSRLHDVLMELQKKQLQQLSA---WLTLT 437
              +++  +   +  LN  +E +  +S    RQS      + L++K    +SA   WL   
Sbjct: 6273 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS------IHLEQKLYDGVSATSTWLDDV 6326

Query: 438  EERI--------QKMETCPLDD-----DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV 484
            EER+        ++ ETC  +      D+K + + ++++K+L S    E    N     V
Sbjct: 6327 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE----NGDNRDV 6382

Query: 485  VIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL----QEINILWQELLEEQCL 540
            +       E     L  +L  L       C   +ER  ++     ++ +L+  L + + +
Sbjct: 6383 I-------EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI 6435

Query: 541  LKAWLT--------EKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE 592
            +   L         E+ EA+ + +       KE    +  L    + +++++ ++ +LS+
Sbjct: 6436 ILQKLANVFEQPVAEQIEAIQQAEDG----LKEFDAGIIELKRRGDKLQVEQPSMQELSK 6491

Query: 593  IGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDL 652
            +     +L+    + +   + +  L  +++  +Q L D      + +A      +  K+ 
Sbjct: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551

Query: 653  LETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK--WKTAI 710
            ++ +  + +   +  +  +       ++ I   ++ + +F        + +LK   K  +
Sbjct: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611

Query: 711  QTTEIKEYMKM--QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG-----KEG 763
            +   I E      +D  E+ ++L+ +E      IP    + +    L++++      K  
Sbjct: 6612 ELEYILETWSHLDEDQQELSRQLEVVESS----IPSVGLVEENEDRLIDRITLYQHLKSS 6667

Query: 764  LPTEEIKNVLEKVSSEWKN--VSQHLEDLERKI-QLQE----DINAYFKQLDELEKVIKT 816
            L   E +  L +V  + K   +S    DLE ++ QL E    + N   K+L  LE ++K 
Sbjct: 6668 L--NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK- 6724

Query: 817  KEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQ 876
               W ++ S S      L S KD  +      + +  ++EM R   +A +      D   
Sbjct: 6725 --HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQS 6782

Query: 877  RGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV 936
                S L     +    +     L +EL  +    + + L  +  V    E   Q+ ++ 
Sbjct: 6783 SLKSSVLSTGNQLLRLKKVDTATLRSELS-RIDSQWTDLLTNIPAV---QEKLHQLQMDK 6838

Query: 937  LNDLAKVEKALQEKKTLDEILENQKP---------ALHKLAEETKALEKNVH-------- 979
            L     + + +     ++ +++  +          A+H+  ++ K  + +++        
Sbjct: 6839 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 6898

Query: 980  ----------PDVE--KLYKQEFDDVQGKWNK----LKVLVSKDLHLLEEIALTLRAFEA 1023
                       DVE  +  K +F +  G  NK    L+ LV++ + LLE +  +   +E 
Sbjct: 6899 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 6958

Query: 1024 DSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNL 1083
            +   ++ W +  ++  +KQQ   GD A +Q  L  C    + I+  E  ++ +++    L
Sbjct: 6959 NVQCLKTWFE-TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7017

Query: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143
                   + + V + L +       L   +   K  L    ++ ++ K    ++  ++ +
Sbjct: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077

Query: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203
            A            S E ++  V+ ++  ++D L+K+ R                      
Sbjct: 7078 ARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD-LEKQERS--------------------- 7115

Query: 1204 TSELNVVLENYQLLCNRIRGKCH---------TLEEVWSCWIELLHYLDLETTWLNTLEE 1254
                   L+ +  + N++  +CH         TL+EV   W  LL            + E
Sbjct: 7116 -------LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLE----------EIAE 7158

Query: 1255 RMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAF 1314
            +++S++ L +      +  +   S ++   D   +  EL +   +  I DD ++  ++  
Sbjct: 7159 QLQSSKALLQLWQRYKDYSKQCASTVQQQED---RTNELLKAATNKDIADDEVATWIQDC 7215

Query: 1315 NSRYEDLSHLAESKQISLEKQLQVLRET-DQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373
            N   + L         +++  L  L E  +Q+ Q +  S     +     L+  + A + 
Sbjct: 7216 NDLLKGLG--------TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE- 7266

Query: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433
             Q   K Q  + A  L  E   +++ +      E+         ++LQ +    S+    
Sbjct: 7267 -QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE--------EILQGQDPSHSSDLST 7317

Query: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVE 1493
             Q      +RM + K           +L    + PD     LD+  +L   L     E++
Sbjct: 7318 IQ------ERMEELKG---------QMLKFSSMAPD-----LDRLNELGYRLPLNDKEIK 7357

Query: 1494 TVIKTGRH--IVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKK 1551
             +    RH  ++  Q T+               ++ L + + + +  LE+       + +
Sbjct: 7358 RMQNLNRHWSLISSQTTER--------------FSKLQSFLLQHQTFLEKCETWMEFLVQ 7403

Query: 1552 EAASLSEWLSATETELVQKSTSEGLL-GDLDTEISWAKNVLKD----LEKRKAD-LNTIT 1605
                L+  +S     L+++  +  L   ++ +      +++ D    LE+ + D  +   
Sbjct: 7404 TEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN 7463

Query: 1606 ESSAALQNLIEGSEPILEERLCVLNAG---WSRVRTWTEDWCNTLMNHQNQLEIFDGNVA 1662
                 L N  +G     ++R  ++++    W R R   E     L+   + L +    + 
Sbjct: 7464 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE-VSYLPM--SGLG 7520

Query: 1663 HISTWLYQAEALLDEIE--KKPTSKQE-------EIVKRLVSELD---DANLQVENVRDQ 1710
             +   L QA  L DE++  +K   +Q+       E  K+L+   D   +A LQ E     
Sbjct: 7521 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE----L 7576

Query: 1711 ALILMNARGSSSR-ELVEPKLAELNRNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETFE 1767
            A I    + +S R E  + KLA L +++EK  + I  +  KL   ++ L Q L      E
Sbjct: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE-E 7635

Query: 1768 TGVPFSDLEKLENDIEN---------MLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEE 1818
                    ++LEN + +         +LK       S+D+   ++E   ++E + ++ EE
Sbjct: 7636 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE---RVELLQRQWEE 7692

Query: 1819 MLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINK 1878
            + HQ         + L+   +  R N+      + +++              ++L ++  
Sbjct: 7693 LCHQ---------LSLRRQQIGERLNEWAVFSEKNKEL-------------CEWLTQMES 7730

Query: 1879 ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA-VIHEKQPDVILE 1937
             +    D+ +   + +L     E+ +  +++    K QL ++GE++A   HE +      
Sbjct: 7731 KVSQNGDILIEEMIEKLKKDYQEEIAIAQEN----KIQLQQMGERLAKASHESK------ 7780

Query: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997
                 A +I   L ++N +W  +  + + R       +   +Q   +++ L  W+   E 
Sbjct: 7781 -----ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7835

Query: 1998 -----LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL----SQ 2048
                 ++ D+C    S ++++    QQEL+  I  H    A++    + ++       + 
Sbjct: 7836 ELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892

Query: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108
            A+   +++    L++RW  I A   +R+ +++   +   K+         WL  +E    
Sbjct: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952

Query: 2109 KRST-----TELGENLQELRDLTQEMEVHAEKLKWLN----RTELEMLSDKSLSLPERDK 2159
              S+     T   E L++     +++     +L+ +N    R   E  +D + SL     
Sbjct: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL----- 8007

Query: 2160 ISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219
              + +   N  W+ + + V + L+                H   Q+    ++   I V  
Sbjct: 8008 -KQMVHEGNQRWDNLQKRVTSILRRL-------------KHFIGQREEFETARDSILV-- 8051

Query: 2220 HRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQR 2279
                                 WL  +D  L +NI    + + +   + ++K  + ++   
Sbjct: 8052 ---------------------WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLN 8088

Query: 2280 HPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSL 2339
            H +++ +    + L  K+   D    I E+L+ ++         VE   ++L  + +   
Sbjct: 8089 HNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD- 8146

Query: 2340 QWDDHREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVMAFDN 2396
              D+H     EL  +  A L  L    R     L+ Q S N  L               +
Sbjct: 8147 --DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL---------------S 8189

Query: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFL 2456
            + Q L  E    DT     + + +   W +      D ++A+     +     +D ++F 
Sbjct: 8190 LAQPLRSERSGRDT---PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246

Query: 2457 K---------WIQEA-----ETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAH 2502
                       I E+     + T N + + S   +AL+  I  R+L + + D + +I   
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI--RQLGKALDDSRFQIQQT 8304

Query: 2503 NDIFKS-------IDGNRQKMVKALGNS----EEATMLQHRLDDMNQ------------- 2538
             +I +S       +D + +  +K LG      +    L+H+L +  +             
Sbjct: 8305 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8364

Query: 2539 -------RWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK--KQMPIG 2589
                   RW  L+A++ S    ++ + +KW +    L  +  WL   +EEL+  +++ + 
Sbjct: 8365 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 8424

Query: 2590 GDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELT 2649
             D+  ++LQ    K L++           AVD  +  +    + +PE  + +        
Sbjct: 8425 TDIQTIELQIKKLKELQK-----------AVDHRKAIILSINLCSPEFTQAD-------- 8465

Query: 2650 PEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE 2709
                  K ++ ++ + S++  +W+ + ++   W+  +  AL + +        L   ++ 
Sbjct: 8466 -----SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 8520

Query: 2710 AESVRNGWKPV-GDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-LSPLDLHPS 2767
             +  +N   P+  +L  + LQDH +++M  + E+     +V ++ D+S Q L   +    
Sbjct: 8521 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 8580

Query: 2768 LKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTS 2813
            L+   ++  +  R KLL   V   +K+L++   D   S Q   S S
Sbjct: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 8625



 Score = 93.6 bits (231), Expect = 3e-18
 Identities = 374/2096 (17%), Positives = 791/2096 (37%), Gaps = 283/2096 (13%)

Query: 272  KYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDS-------YQIALEEVLTW 324
            KY +E E E +  +      +H     E  STV +  M L+        +    + +  W
Sbjct: 3761 KYLEEGEAERLRKEI----HDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQW 3816

Query: 325  LLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGN---QLITQGT 381
            +   ++     ++   ++ E K Q + +++    + +H+ SV SV + G    +L+   T
Sbjct: 3817 IAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT 3876

Query: 382  LSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLME-----------LQKKQLQQL 430
            L D+ + ++Q     L +  +A+  E    + RL+++ M+           LQ K  Q +
Sbjct: 3877 LKDKID-QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNV 3935

Query: 431  SAWLTLTEERIQKMETCPLDDDV-KSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE 489
             A L  T++    +  C     + +SL+  L++H S Q  L+  Q  ++++   +    +
Sbjct: 3936 HAHLQGTKDSYSAI--CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 3993

Query: 490  NSGESATAI--------LEDQLQKLGERWTAVC------------------RWTEERWNR 523
                 A AI        L++Q +   +   ++C                  +  E++  +
Sbjct: 3994 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQ 4053

Query: 524  LQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMK 583
             Q +   W+E+   +  L  +L + ++ L  ++  +   + EL+++   ++ +K+ ++  
Sbjct: 4054 AQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH--SELELNIAQNMVSQVKDFVKKL 4111

Query: 584  RQTLDQLSEIGQDVGQLL--DNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAK 641
            +     ++ I + V +L   + S   K+IN     L  +W  L ++   S+N   Q    
Sbjct: 4112 QSKQASVNTIIEKVNKLTKKEESPEHKEIN----HLNDQWLDLCRQ---SNNLCLQREED 4164

Query: 642  LGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLN 701
            L  ++    D +  V V      +K   E             V +EA KK      E   
Sbjct: 4165 LQRTR-DYHDCMNVVEV----FLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKY 4219

Query: 702  WILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGK 761
             I   K   Q  ++ E++ + D   +K++   LE+         D + +  Q+ V  + +
Sbjct: 4220 AIEDLKD--QKQKMIEHLNLDDKELVKEQTSHLEQRW---FQLEDLIKRKIQVSVTNLEE 4274

Query: 762  EGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWV 821
              +     + ++E    +  N+++ L+        Q  +  +     EL           
Sbjct: 4275 LNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSEL----------- 4323

Query: 822  KHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDS 881
                  E+ +  L SL     R + + LGL+ +                    +Q+    
Sbjct: 4324 ------EAKQMLLKSLIKDADRVMAD-LGLNER------------------QVIQKALSD 4358

Query: 882  FLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLA 941
                   + + V  R+++L   L  +    +L  +      +   E K     ++     
Sbjct: 4359 AQSHVNCLSDLVGQRRKYLNKALSEKT--QFLMAVFQATSQIQQHERKIMFREHICLLPD 4416

Query: 942  KVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLK 1001
             V K ++  K+    L+  +  +  L  + + L K V    +     +  ++Q  ++ + 
Sbjct: 4417 DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL 4476

Query: 1002 VLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
               S  L  LE+  ++ + F+ D      W+         +     + + L  QL +   
Sbjct: 4477 QKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQN 4536

Query: 1062 FVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS 1121
             + +    E+ L  ++     +         +++  +L     Q   +   +A  K +  
Sbjct: 4537 ILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVI---VALAKDKFY 4593

Query: 1122 ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKED---VLQK 1178
            + QE A   +K+ A + E  TQ+  E LE  F   S    + AVEE    ++    +L +
Sbjct: 4594 KVQE-AILARKEYASLIELTTQSLSE-LEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4651

Query: 1179 EVRVKILKDNIKLLAAKVPSGGQELTSELNVVLEN-YQLLCNRIRGKCHTLEEVWSCWIE 1237
               +    D +        S GQ    +  + L   Y  L  +   +   LE+  S + E
Sbjct: 4652 VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQE 4711

Query: 1238 LLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQI-RELGQT 1296
                          LE ++KS +   E+   VNE  E+L      PA+ + ++   L  +
Sbjct: 4712 -------HEKMCQQLERQLKSVK---EEQSKVNE--ETL------PAEEKLKMYHSLAGS 4753

Query: 1297 LIDGGILDDIISEKLEAFNSRYEDLS-HLAESKQISLEKQLQVLRETDQMLQVLQESLGE 1355
            L D GI+       L+      EDL+ HL     ++ EK    ++     L++L  ++GE
Sbjct: 4754 LQDSGIV-------LKRVTIHLEDLAPHL---DPLAYEKARHQIQSWQGELKLLTSAIGE 4803

Query: 1356 LDKQLTTYLTDRIDAFQVPQE-----AQKIQAEISAH---ELTLEELRRNMRSQPLTSPE 1407
               +  + +   ID FQ          ++++AE+S     +L L++++  +R   +   E
Sbjct: 4804 TVTECESRMVQSID-FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE 4862

Query: 1408 SRTARGGSQMDVLQRKLREVSTKFQ------------------------LFQKPANFEQR 1443
             +++     M+ L  K +E  TK +                        L  + A   + 
Sbjct: 4863 VQSSL--RIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920

Query: 1444 MLDCKRVLDGVKA---------ELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVET 1494
               C+R     +A         EL  L    +D +  + +L   M+ + T  +    +E 
Sbjct: 4921 YSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEE 4980

Query: 1495 VIKTGRHIVQKQQTDNPKGMDEQLTSLKV----LYNDLGAQVTEGKQDLERASQLARKMK 1550
            +      +    +    + +++++ SL++    +  D GAQV      L+R +      +
Sbjct: 4981 LHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV----DLLQRCTAQWHDYQ 5036

Query: 1551 KEAASLSEWLSATETELVQKS-TSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSA 1609
            K    + E ++ TE +L + S        + + ++S  K ++  +      +  + E ++
Sbjct: 5037 KAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKAS 5096

Query: 1610 ALQNL-IEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWL 1668
             L+    + S+  L   +  +   W+R+R   +D    L +  ++   F+  V   +  +
Sbjct: 5097 QLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMI 5156

Query: 1669 YQAEALLDEIEKKPTSKQE-----EIVKRLVSELDDANLQVENVRDQALILMNARGSSSR 1723
             Q +  L     +  SK E     E     V EL+     +  +R Q L ++    + + 
Sbjct: 5157 DQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTP 5216

Query: 1724 ELVEPKLAELNRNFEK---VSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
                P + E+    ++   + + +K+   L+ QE                   D E +E 
Sbjct: 5217 GEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE-----------------LKDREMVET 5259

Query: 1781 DIENMLKFVEKHLE-----SSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
             I ++  +V++  E     + + D +++E    + E      + + +  E+ K++ + L 
Sbjct: 5260 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH-RQNIEKMAEEQKEKYLGLY 5318

Query: 1836 LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPEL 1895
             +L      ++  + +  +   Q+   I+         VE +K        ELS  + +L
Sbjct: 5319 TILPSELSLQLAEVALDLKIRDQIQDKIKE--------VEQSK----ATSQELSRQIQKL 5366

Query: 1896 N---TAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV------ILEASGPEAIQI 1946
                T I      + D++   K     LGE++   + K  ++       LE +G     +
Sbjct: 5367 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5426

Query: 1947 RDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPG 2006
               + +L     +  R   +R    ++A     +++  L  + +WI +A+ L   T A  
Sbjct: 5427 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN 5486

Query: 2007 GSLDL-EKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKL----AGL 2061
             +  L E+  +HQ  LE            ++   + + +KL      +  EK+    A L
Sbjct: 5487 SASQLREQYILHQTLLE--------ESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538

Query: 2062 NQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELG--ENL 2119
             +  + +   +K R   L+  +K + K+  +L ++   L +A+  +       L   E L
Sbjct: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598

Query: 2120 QELRDLTQEMEVHAEKLK--WLNRTELEMLSDKSLSLP---ERDKISESLRTVNMTWNKI 2174
               + L  EME    K++   L ++ L +  D   SLP      ++ E    +  T  + 
Sbjct: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ 5658

Query: 2175 CREVPTTL---KECIQEPSSVSQTRIAAHPNVQ-KVVLVSSASDIPVQSHRTSEIS 2226
            C  +   +   ++  QE   + Q    AH  ++ K V  S+  ++  Q  R  E++
Sbjct: 5659 CNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELA 5714



 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 59/289 (20%), Positives = 133/289 (46%), Gaps = 32/289 (11%)

Query: 259  TIDAIREVETLPRKYKKECEEEA----INIQSTAPE-----EEHESPRAETPSTVTEVDM 309
            +ID+++ +E     +K + EEE+    +N+ ST  +     +  E  +A+  S    +  
Sbjct: 8335 SIDSVKRLE-----HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQ 8389

Query: 310  DLDSYQ---IALEEVLTWLLSAEDTFQEQD--DISDDVEEVKDQFATHEAFMMELTAHQS 364
            +L  +Q     L  +  WL   E+  ++    ++S D++ ++ Q    +     +   ++
Sbjct: 8390 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKA 8449

Query: 365  SVGSVLQAGNQLITQGTLSDEEEF-EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQ 423
             + S+    N    + T +D +E  ++Q++++ +N RW+ +     + +  L D LM+ Q
Sbjct: 8450 IILSI----NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8505

Query: 424  KKQLQQLSAWLTLTEERI--QKMETCPLDDDVKSLQKLLEEHKSL---QSDLEAEQVKVN 478
                 ++S  L L  E I  +K E  P+D ++ + + L + HK L   + +L   Q++V 
Sbjct: 8506 --GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA-EILQDHHKQLMQIKHELLESQLRVA 8562

Query: 479  SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527
            SL  M   +  N+  +     ++++  +G R   + +        L+++
Sbjct: 8563 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 8611



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 79/396 (19%), Positives = 153/396 (38%), Gaps = 74/396 (18%)

Query: 1051 GLQRQLDQCSAFVNEIETIESSLKNMKEIE---TNLRSGPVAGIKTWVQTRLGDYQTQLE 1107
            G  + L +CS+ ++ ++ +E  LK  +E      NL S          +T+      + E
Sbjct: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS---------TETQTAGVIDRWE 8374

Query: 1108 KLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEE 1167
             L  +  +++ R+ ++ +K      DL  +  W+   EEE LE+    +   ++++   +
Sbjct: 8375 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQ 8433

Query: 1168 MKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGK--- 1224
            +K+ KE  LQK V      D+ K +   +     E T   +    + Q   +++ G+   
Sbjct: 8434 IKKLKE--LQKAV------DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485

Query: 1225 -CHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHP 1283
             C  LEE                 W   L++ +   +   E +  +   LE+++      
Sbjct: 8486 VCSLLEE-----------------WRGLLQDALMQCQGFHEMSHGLLLMLENIDR----- 8523

Query: 1284 ADNRTQIRELGQTLIDGGILDD----IISEKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339
               + +I  +   L D  IL D    ++  K E   S+    S    S Q+ +  +    
Sbjct: 8524 --RKNEIVPIDSNL-DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 8580

Query: 1340 RETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHEL--------TL 1391
             E  + + V+   L  L K+++ ++ +      V    Q + +  SA EL        T 
Sbjct: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTS 8640

Query: 1392 EELRRNMRSQP------------LTSPESRTARGGS 1415
                 N +  P            ++SP SR+ +GGS
Sbjct: 8641 GRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS 8676



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 123/633 (19%), Positives = 234/633 (36%), Gaps = 79/633 (12%)

Query: 199  WDKVVKMSPIERL--EHAFSKAQTYLG----IEKLLDPEDVAVQLPDKKSIIMYLTS--- 249
            W  +  MS   RL  E  +   Q +L      E  L   +     P    +I  +     
Sbjct: 7909 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 7968

Query: 250  -LFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRA--ETPSTVTE 306
              FE   +QV  + + ++E + ++Y++   E   +   +  +  HE  +        VT 
Sbjct: 7969 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8027

Query: 307  VDMDL-------DSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMEL 359
            +   L       + ++ A + +L WL   +      +  S+   +V+ +    +AF  E+
Sbjct: 8028 ILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQAKIKQLKAFQQEI 8085

Query: 360  TAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL 419
            + + + +  ++  G QLI +    D     I+E++  L    +    E   R  R H  L
Sbjct: 8086 SLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQ----EVFGRVERYHKKL 8139

Query: 420  MELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVN- 478
            + L     +       L++  ++  ++  L D        L  H      L + Q   N 
Sbjct: 8140 IRLPLPDDEH-----DLSDRELELEDSAALSD--------LHWHDRSADSLLSPQPSSNL 8186

Query: 479  SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNR-LQEINILWQE---- 533
            SL+    +  E SG    A + D +    +    + R  E   +R L   +   Q+    
Sbjct: 8187 SLSLAQPLRSERSGRDTPASV-DSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDF 8245

Query: 534  -LLEEQCLLKAWLTEKEEALNKVQTSNFK----DQKELSVSVRRLAILKEDMEMKRQTLD 588
             L     L    + E  EA  K+  +  K    D   L   +R+L    +D   + Q  +
Sbjct: 8246 YLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTE 8305

Query: 589  QLSEIGQDVGQLLDNS-KASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQI 647
             +       G  LD S K   K+  +          L  +L++    +   V  L  ++ 
Sbjct: 8306 NIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV-NLHSTET 8364

Query: 648  PQKDLLETVR-VREQAITK--KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI- 703
                +++    ++ QA++K  + KQ L      K +Q + D+ +   +   + E L  + 
Sbjct: 8365 QTAGVIDRWELLQAQALSKELRMKQNL-----QKWQQFNSDLNSIWAWLGDTEEELEQLQ 8419

Query: 704  -LKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKE 762
             L+  T IQT E++            KKLK L+K    R      +N       +   KE
Sbjct: 8420 RLELSTDIQTIELQ-----------IKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 8468

Query: 763  GLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQ 795
               + ++++ L +++  W  V   LE+    +Q
Sbjct: 8469 ---SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8498


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  281 bits (719), Expect = 8e-75
 Identities = 430/2047 (21%), Positives = 821/2047 (40%), Gaps = 333/2047 (16%)

Query: 22   IKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKE 81
            IK+ +DE   VQKKTFTKW+N+  ++     I D++ DL+DGR L+ LLE L+G  LPK 
Sbjct: 45   IKALADEREVVQKKTFTKWVNSHLARVSCR-ITDLYKDLRDGRMLIKLLEVLSGEMLPKP 103

Query: 82   -RGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVM 140
             +G  R+H L NV++ LQ L +  V L N+G  DIVDGNH+L LGL+W+IIL +Q++D++
Sbjct: 104  TKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIV 163

Query: 141  KDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWD 200
                   +  +++  LL W +  T  Y  VNV NFT+SW DGLAFNA++H+H+PDL  +D
Sbjct: 164  VQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFD 223

Query: 201  KVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQ--- 257
            K+   +    LEHAF+ A+  LGI  LLDPEDV  + PD+KSII Y+ + +    +    
Sbjct: 224  KLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVL 283

Query: 258  --------VTIDAIREVETLPRKYKKECEE---------EAINIQSTAPEEEHESPRAET 300
                      ID   E E +  KY     +           +N +  A        + + 
Sbjct: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343

Query: 301  PSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQ-----------DDISDDVEEVKDQF 349
             ST   V+      +    EVL + + +      Q            DI+   E +++  
Sbjct: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403

Query: 350  ATHEAFMMELTAHQSSVGSVLQAGNQ--LITQGTLSDEEEFEIQEQ-------MTLLNAR 400
               E  +      Q  +  + +  ++   + +  LS+ +    Q+        +     +
Sbjct: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKK 463

Query: 401  WEALRVESM---DRQSRLHDVLMELQKKQLQQ-----------LSAWLTLTE---ERIQK 443
             EA+  ++    +R   L D+  EL+K+               L  W  L E    R Q+
Sbjct: 464  HEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQR 523

Query: 444  METC------------PLD--DDVKS-------------LQKLLEEHKSLQSDLEAEQVK 476
            +ET              +D  D++K+             ++ LL++HK +++D+  +  K
Sbjct: 524  LETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDK 583

Query: 477  VNSLTHMVVIVDENSGESA--TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQEL 534
            V ++T   +   E  G       +++D++  L + +  +      R  +L++   LW + 
Sbjct: 584  VKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLW-KF 642

Query: 535  LEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQ----- 589
              E    ++W+ EKE+  + +     KD   + +  R+    ++++      L+Q     
Sbjct: 643  FWEMDEAESWIKEKEQIYSSLDYG--KDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700

Query: 590  -----------------LSEIGQDVGQLLDNSKASKKINSDSEELTQ---RWDSLVQRLE 629
                             + E+     QL D +   KK   D+E   Q     D L   L+
Sbjct: 701  HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQ 760

Query: 630  D-----SSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKK----- 679
            D     S   V Q            KD LE +    + + +  +Q+    P   +     
Sbjct: 761  DAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-ESRGVMEHLEQQAQGFPEEFRDSPDV 819

Query: 680  -------RQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTE-----IKEYMKMQDTSEM 727
                   R+++  + A+     +  + L   L   T    T+     + E  K     EM
Sbjct: 820  THRLQALRELYQQVVAQAD---LRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEM 876

Query: 728  KKKLKALEKEQRERIPRADELNQTGQILVEQMG----------KEGLP-TEEIKNVLEKV 776
               L+ LE  Q     R D L+Q  + L+ Q+           + G P + E+K   + +
Sbjct: 877  PDTLEDLEVVQH----RFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHL 932

Query: 777  SSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPS 836
            ++ W+     + +    +     ++ Y    +E  K I  K      T + ES++     
Sbjct: 933  NTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDK------TKVVESTK----- 981

Query: 837  LKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDR 896
                  R+L  ++ +  K+       +A+ ++    D ++R     +  +   +E +  R
Sbjct: 982  ---DLGRDLAGIIAIQRKLSGLERDVAAIQAR---VDALERESQQLMDSHPEQKEDIGQR 1035

Query: 897  QQHLE-------NELKGQPG--------HAYLETLKTLKDVLNDSENKAQVSLNVLNDLA 941
            Q+HLE         L+GQ           A+L+ L   +  L+ ++ KA  S ++   L 
Sbjct: 1036 QKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMPESLP 1094

Query: 942  KVEKALQEKKTLDEILENQKPALHKLAEE-TKALEKNVHPDVEKLYKQEFDDVQGKWNKL 1000
            + E+ LQ+   + + ++  + +  ++ E   K ++    P+   L  Q  + +   WN L
Sbjct: 1095 EAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEY-LLLGQRLEGLDTGWNAL 1153

Query: 1001 KVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCS 1060
              +     H L +  L  + F+ D+   E  +   +  L   +            L+   
Sbjct: 1154 GRMWESRSHTLAQ-CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPD--------SLEAAE 1204

Query: 1061 AFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
            A + + E    S++N ++    + S   +G K   +  L  Y  ++++  + I  +  + 
Sbjct: 1205 AGIRKFEDFLGSMENNRD---KVLSPVDSGNKLVAEGNL--YSDKIKEKVQLIEDRHRKN 1259

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYL--------ERDFEYKSPEELESAVEEMKRAK 1172
            +E  ++A+ L +D  E+Q ++   +E  L         +D  Y     L +   + +   
Sbjct: 1260 NEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV 1319

Query: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
             ++   E  ++ +    K L  + P     ++ +L  +   +  L    + K   L    
Sbjct: 1320 AELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAAR 1379

Query: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIR- 1291
            S  + L  + DL   W++ +E++++S +   + T +VN  L  L+ V     +++  +R 
Sbjct: 1380 SSDLRLQTHADL-NKWISAMEDQLRSDDPGKDLT-SVNRMLAKLKRV-----EDQVNVRK 1432

Query: 1292 -ELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEK---QLQVLRETDQMLQ 1347
             ELG+       + +   +   +   R+ DL      ++  LE    +LQ+ R+ +    
Sbjct: 1433 EELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETL 1492

Query: 1348 VLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPE 1407
             ++E L     Q   Y T+        ++ Q +Q EI  H   +E++ +  R Q L    
Sbjct: 1493 WVEERLPL--AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ--RGQQLVEAA 1548

Query: 1408 SRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVD 1467
                +       L+ +L  + + +   ++ A         +R+ D  +A+ + LD  + +
Sbjct: 1549 EIDCQD------LEERLGHLQSSWDRLREAAAGR-----LQRLRDANEAQQYYLDADEAE 1597

Query: 1468 PDVIQTHLDKCMKLYKTLSEV-KLEVETVIKTGRHIVQ-----------KQQTDNPKGM- 1514
              + +       +LY    E+ K E   ++   RH+ Q           KQ     +G+ 
Sbjct: 1598 AWIGE------QELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLL 1651

Query: 1515 ------DEQLTSLK----VLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564
                   EQ+  L+      Y  L     E K+ LE    L  ++K+E   L +W+S  E
Sbjct: 1652 SAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF-QLKRETDDLEQWIS--E 1708

Query: 1565 TELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEE 1624
             ELV  S   G   D D  ++  ++  +D  +         E+ A  Q  ++     +E 
Sbjct: 1709 KELVASSPEMG--QDFD-HVTLLRDKFRDFAR---------ETGAIGQERVDNVNAFIER 1756

Query: 1625 RLCVLNAGWSRVRT---W----TEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDE 1677
               +++AG S   T   W     E W + L     ++++   +   +  + Y    +L  
Sbjct: 1757 ---LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY-DLHRYFYTGAEILGL 1812

Query: 1678 IEKKPTSKQEE-------------IVKRLVSELDDANLQVENVRDQALILMNARGSSSRE 1724
            I++K     E+             +      EL    +QV+  +D A  L  A      E
Sbjct: 1813 IDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872

Query: 1725 LVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIEN 1784
             ++ K  E++  ++ +       +         Q + T + F     FS    L + +E+
Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRT--------QLVDTADKFRF---FSMARDLLSWMES 1921

Query: 1785 MLKFVEKHLESSDE-------------DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEK 1831
            +++ +E      D              + +++  S      L+ GE +L +  + +++ +
Sbjct: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981

Query: 1832 IRLQLLL 1838
             +LQ ++
Sbjct: 1982 EKLQQVM 1988



 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 288/1573 (18%), Positives = 602/1573 (38%), Gaps = 223/1573 (14%)

Query: 1299 DGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQL-------QVLRETDQMLQVLQE 1351
            DG ++ DI        N  +E L      ++++L  +L       Q+ R  D+   + + 
Sbjct: 385  DGKLVSDI--------NRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRET 436

Query: 1352 SLGELDKQLTT----YLTDRIDAFQVPQEAQKIQAEISAHE---LTLEELRRNMRSQPLT 1404
             L E  + +      Y    ++A +   EA  I+ + +A+E     LE+L + +  +   
Sbjct: 437  WLSENQRLVAQDNFGYDLAAVEAAKKKHEA--IETDTAAYEERVRALEDLAQELEKENYH 494

Query: 1405 SPESRTARGGSQMDV---LQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAEL--- 1458
              +  TAR  + + +   LQ  L+    + +         Q ML     +D +KA L   
Sbjct: 495  DQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSA 554

Query: 1459 ----HVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGM 1514
                H+L+V+D+    +Q H  K M+    +   K++  T         +  Q  +P+ +
Sbjct: 555  EFGKHLLEVEDL----LQKH--KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVI 608

Query: 1515 DEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSE 1574
             ++++ L+  + +L       K  LE++ +L  K   E      W+   E E +  S   
Sbjct: 609  QDRISHLEQCFEELSNMAAGRKAQLEQSKRLW-KFFWEMDEAESWIK--EKEQIYSSLDY 665

Query: 1575 GLLGDLDTEISWA---KNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNA 1631
            G   DL + +      K    +L    A L  I + +  +    +   P +E R+  ++A
Sbjct: 666  GK--DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSA 723

Query: 1632 GWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALL-------DEIEKKPTS 1684
             W +++         L + +N  + F G+   +  WL  A  LL       DE   +   
Sbjct: 724  QWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALG 782

Query: 1685 KQEEIVKRLVSELDDANLQVENVRDQALIL---------MNARGSSSRELVEPKLAELNR 1735
            K+    K  + EL+++   +E++  QA            +  R  + REL +  +A+ + 
Sbjct: 783  KKH---KDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADL 839

Query: 1736 NFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLES 1795
              +++ + +           LY     T+  E  +   +    E ++ + L+ +E     
Sbjct: 840  RQQRLQEALD----------LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHR 889

Query: 1796 SDE-DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR 1854
             D  D++M     QI+ V      ++       +  +++     L+TR+   + +  ++R
Sbjct: 890  FDILDQEMKTLMTQIDGVNLAANSLVESGHP--RSREVKQYQDHLNTRWQAFQTLVSERR 947

Query: 1855 KMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIK 1914
            +       + S+L   +Y V+  +    + D      V E    +  D +     +  I+
Sbjct: 948  E------AVDSALRVHNYCVDCEETSKWITD---KTKVVESTKDLGRDLA----GIIAIQ 994

Query: 1915 DQLDKLGEQIAVIH------EKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRK 1968
             +L  L   +A I       E++   ++++   +   I      L   W  + +    ++
Sbjct: 995  RKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQE 1054

Query: 1969 GCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSH 2028
                  + + + F  DL+D   W++  ++ +     P    + E+       ++  I  H
Sbjct: 1055 DLLGE-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGH 1113

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMK 2088
            Q S+  +  +G+ ++Q  +  +   L ++L GL+  W+A+    + R   L  +     +
Sbjct: 1114 QDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL-AQCLGFQE 1172

Query: 2089 YRHQLDEIICWLTKAEHA---MQKRSTTELGE-NLQELRDLTQEMEVHAEKLKWLNRTEL 2144
            ++    +    L+  E+    ++   + E  E  +++  D    ME + +K+     +  
Sbjct: 1173 FQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGN 1232

Query: 2145 EMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQ 2204
            +++++ +L     DKI E ++ +     K          E  QE S + +  +     +Q
Sbjct: 1233 KLVAEGNL---YSDKIKEKVQLIEDRHRK--------NNEKAQEASVLLRDNLELQNFLQ 1281

Query: 2205 KVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINK 2264
                                            EL  W  + D++L S  V+  +   ++ 
Sbjct: 1282 -----------------------------NCQELTLW--INDKLLTSQDVSYDEARNLHN 1310

Query: 2265 TVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGV 2324
               + +   A+L      L+ +    + L ++         +++KLE +   WD  Q   
Sbjct: 1311 KWLKHQAFVAELASHEGWLENIDAEGKQLMDE--KPQFTALVSQKLEALHRLWDELQATT 1368

Query: 2325 ELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQEL 2384
            + + Q L      + +  D R +T   + K+ + +    Q R D   K ++    +L +L
Sbjct: 1369 KEKTQHL-----SAARSSDLRLQTHADLNKWISAME--DQLRSDDPGKDLTSVNRMLAKL 1421

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
               +  V      L +L  +  S       +    ++  +++L + +  R+  LE+    
Sbjct: 1422 KRVEDQVNVRKEELGELFAQVPSMGEEG-GDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q S RDLE+   W++E       L  ++     LQ   L     ++ Q +Q EI  H  
Sbjct: 1481 LQIS-RDLEDETLWVEERLP----LAQSADYGTNLQTVQL---FMKKNQTLQNEILGHTP 1532

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
              + +    Q++V+A     +   L+ RL  +   W+ L+ ++A+ R      A +  + 
Sbjct: 1533 RVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRLR-EAAAGRLQRLRDANEAQQY 1589

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +  +E   W+   ++EL     I  ++P                K++E     A+   +
Sbjct: 1590 YLDADEAEAWIG--EQEL---YVISDEIP----------------KDEE----GAIVMLK 1624

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKA-------MRKQSSEVKEKWESLNA 2677
              L  Q   A E+  RN++         RAQ +  A       + +   +V + +  L  
Sbjct: 1625 RHLRQQ--RAVEDYGRNIKQLA-----SRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKD 1677

Query: 2678 VTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGD-----LLIDSLQDHI 2732
            V    +++++  +  L  L+   DDL+  + E E V +  +   D     LL D  +D  
Sbjct: 1678 VAEERKRKLEN-MYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFA 1736

Query: 2733 EKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRL 2792
             +  A  +E      +V  VN    +L       +  ++   D LN  W  L   +D R+
Sbjct: 1737 RETGAIGQE------RVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRM 1790

Query: 2793 KQL---QEAHRDF 2802
            + L    + HR F
Sbjct: 1791 QLLAASYDLHRYF 1803



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 253/1334 (18%), Positives = 499/1334 (37%), Gaps = 173/1334 (12%)

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLND---SENKAQVSL-NVLNDLA 941
            +++++EA   R+  L NEL  Q     L      K  + +   SEN+  V+  N   DLA
Sbjct: 396  WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455

Query: 942  KVEKALQEKKTLDE---ILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWN 998
             VE A ++ + ++      E +  AL  LA+E   LEK  + D +++  ++ D++   W+
Sbjct: 456  AVEAAKKKHEAIETDTAAYEERVRALEDLAQE---LEKENYHDQKRITARK-DNILRLWS 511

Query: 999  KLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQR 1054
             L+ L+      LE   L L+    D      WMD +K  L+  +  +     +D   + 
Sbjct: 512  YLQELLQSRRQRLET-TLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570

Query: 1055 QLDQCSAFV--NEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKE 1112
            +L +    +  ++++ I ++     E +      P       +Q R+   +   E+LS  
Sbjct: 571  KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQV-----IQDRISHLEQCFEELSNM 625

Query: 1113 IATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAK 1172
             A +K++L +S+ +      ++ E + W+ + E+ Y   D+       L   ++   +A 
Sbjct: 626  AAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL--ILQRKHKAF 682

Query: 1173 EDVLQK-EVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEV 1231
            ED L+  +  ++ +      + A+   G  ++ + +  V   +  L +        L++ 
Sbjct: 683  EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742

Query: 1232 WSCWIELLHYLDLETTWLNTLEERMK---------STEVLPEKTDAVNEALESLESVLRH 1282
             + + +     D    WL      +          +T  L +K     E LE    V+ H
Sbjct: 743  EN-FFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEH 801

Query: 1283 PADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQ---VL 1339
                     E  +   D       ++ +L+A    Y+ +   A+ +Q  L++ L    V 
Sbjct: 802  LEQQAQGFPEEFRDSPD-------VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVF 854

Query: 1340 RETDQMLQVLQESLGELDKQLTTY-LTDRIDAFQV--------PQEAQKIQAEISAHELT 1390
             ETD      +  +GE +K L    + D ++  +V         QE + +  +I    L 
Sbjct: 855  GETD----ACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLA 910

Query: 1391 LEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLRE----VSTKFQLFQKPANFEQRMLD 1446
               L  +        P SR  +     D L  + +     VS + +            +D
Sbjct: 911  ANSLVESGH------PRSREVK--QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD 962

Query: 1447 CKRVLDGVKAELHVLD-VKDVDPDV--IQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIV 1503
            C+     +  +  V++  KD+  D+  I     K   L + ++ ++  V+ + +  + ++
Sbjct: 963  CEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLM 1022

Query: 1504 QKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSAT 1563
                 +  + + ++   L+ L+  L  Q  +G++DL       +   ++      WLS T
Sbjct: 1023 DSHP-EQKEDIGQRQKHLEELWQGL-QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080

Query: 1564 ETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSA-ALQNLIEGSEPIL 1622
            +  +  +   E L  + +  +     +  +++  +     + ES    +Q   +    +L
Sbjct: 1081 QKAVASEDMPESL-PEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLL 1139

Query: 1623 EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKP 1682
             +RL  L+ GW+ +    E   +TL       E F  +       L   E  L  +E   
Sbjct: 1140 GQRLEGLDTGWNALGRMWESRSHTLAQCLGFQE-FQKDAKQAEAILSNQEYTLAHLEPPD 1198

Query: 1683 TSKQEEIVKRLVSELDDANLQVENVRDQALILMN------ARGSSSRELVEPKLAELNRN 1736
            + +  E   R   + +D    +EN RD+ L  ++      A G+   + ++ K+  +   
Sbjct: 1199 SLEAAEAGIR---KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDR 1255

Query: 1737 FEKVSQHIKSAKLLIA-----QEPLYQCLVTTETFET------GVPFSDLEKLENDIENM 1785
              K ++  + A +L+      Q  L  C   T            V + +   L N     
Sbjct: 1256 HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKH 1315

Query: 1786 LKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNK 1845
              FV +        E +D E  Q+ +   +   ++ Q +E             LH  +++
Sbjct: 1316 QAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLE------------ALHRLWDE 1363

Query: 1846 IKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSF 1905
            ++A     ++  Q  S  RSS L      ++NK +  M+D   S +  +  T++    + 
Sbjct: 1364 LQATT---KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLA- 1419

Query: 1906 QEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYS 1965
                LK ++DQ++   E++  +  + P +  E    +    +  L  L     R  ++ S
Sbjct: 1420 ---KLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLES 1476

Query: 1966 DRKGCFDRAMEEWRQFHCDLNDLTQWITEA---------------------------EEL 1998
             R            Q   DL D T W+ E                             E+
Sbjct: 1477 SRAKL---------QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527

Query: 1999 L-----VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSF 2053
            L     V+     G   +E A I  Q+LE  +   Q S+  L     G +Q+L  A+   
Sbjct: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDAN--- 1584

Query: 2054 LKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT 2113
                        DA  AE    +  L   S ++ K     DE    +    H  Q+R+  
Sbjct: 1585 -----EAQQYYLDADEAEAWIGEQELYVISDEIPK-----DEEGAIVMLKRHLRQQRAVE 1634

Query: 2114 ELGENLQELRDLTQ 2127
            + G N+++L    Q
Sbjct: 1635 DYGRNIKQLASRAQ 1648



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 280/1450 (19%), Positives = 567/1450 (39%), Gaps = 180/1450 (12%)

Query: 728  KKKLKALEKEQ---RERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVS 784
            KKK +A+E +     ER+   ++L Q  ++  E    +   T    N+L   S   + + 
Sbjct: 461  KKKHEAIETDTAAYEERVRALEDLAQ--ELEKENYHDQKRITARKDNILRLWSYLQELLQ 518

Query: 785  QHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRE 844
               + LE  + LQ+        +D ++++         H   +E  +  L         E
Sbjct: 519  SRRQRLETTLALQKLFQDMLHSIDWMDEI-------KAHLLSAEFGKHLL---------E 562

Query: 845  LTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLEN-- 902
            + +LL  H  +E   A  +    +  A       F    G      + ++DR  HLE   
Sbjct: 563  VEDLLQKHKLME---ADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCF 619

Query: 903  -ELKGQPG--HAYLETLKTLKDV---LNDSEN----KAQV--SLNVLNDLAKVEKALQEK 950
             EL        A LE  K L      ++++E+    K Q+  SL+   DL  V    ++ 
Sbjct: 620  EELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH 679

Query: 951  KTLDEILENQKPALHKLAEETKAL---EKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKD 1007
            K  ++ L      L ++ +E   +   ++  HP +E   K+    V  +W++LK L +  
Sbjct: 680  KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE----VSAQWDQLKDLAAFC 735

Query: 1008 LHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIE 1067
               L++ A     F+ D+  ++ W+      L  +    G D G  R L +     + +E
Sbjct: 736  KKNLQD-AENFFQFQGDADDLKAWLQDAHRLLSGEDV--GQDEGATRALGK--KHKDFLE 790

Query: 1068 TIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQ-LEKLSKEIATQKSRLSESQEK 1126
             +E S   M+ +E   +  P    + +  +    ++ Q L +L +++  Q     +  ++
Sbjct: 791  ELEESRGVMEHLEQQAQGFP----EEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846

Query: 1127 AANLKKDLAEMQE---WMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVK 1183
            A +L     E      WM + E+   E +     P+ LE    E+ + + D+L +E++  
Sbjct: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEM----PDTLEDL--EVVQHRFDILDQEMKTL 900

Query: 1184 ILK-DNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY- 1241
            + + D + L A  +   G   + E+    ++        +       E     + + +Y 
Sbjct: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960

Query: 1242 LDLETT--WLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLID 1299
            +D E T  W+    + ++ST+ L      +      L  + R  A  + ++  L +   +
Sbjct: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALER---E 1017

Query: 1300 GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQ 1359
               L D   E+ E    R + L  L +  Q SL+ Q  +L E  Q+   LQ+     D Q
Sbjct: 1018 SQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLD---DFQ 1074

Query: 1360 LTTYLTDRI-----------DAFQVPQEAQKIQAEISAHELTLEELRRNMRS--QPLTSP 1406
                +T +            +A Q+ Q+   I+ EI  H+ + + ++ +     Q  T P
Sbjct: 1075 AWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134

Query: 1407 E-----SRTARGGSQMDVLQRKLREVSTK------FQLFQKPANFEQRMLDCKRVLDGVK 1455
            E      R     +  + L R     S        FQ FQK A         + +L   +
Sbjct: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK------QAEAILSNQE 1188

Query: 1456 AELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMD 1515
              L  L+  D   +  +  + K      ++   + +V + + +G  +V +    + K + 
Sbjct: 1189 YTLAHLEPPD-SLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-IK 1246

Query: 1516 EQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEG 1575
            E++  ++  +     +  E    L    +L +   +    L+ W++            + 
Sbjct: 1247 EKVQLIEDRHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLWIN------------DK 1293

Query: 1576 LLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEER---------- 1625
            LL   D     A+N+     K +A +  +      L+N+    + +++E+          
Sbjct: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353

Query: 1626 LCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSK 1685
            L  L+  W  ++  T++    L   ++  ++     A ++ W+    A+ D++      K
Sbjct: 1354 LEALHRLWDELQATTKEKTQHLSAARSS-DLRLQTHADLNKWI---SAMEDQLRSDDPGK 1409

Query: 1686 QEEIVKRLVSELDDANLQVENVRDQAL-------ILMNARGSSSRELVEPKLAELNRNFE 1738
                V R++++L     QV NVR + L         M   G  +   +E +  +L     
Sbjct: 1410 DLTSVNRMLAKLKRVEDQV-NVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLG 1468

Query: 1739 KVSQHIKS--AKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESS 1796
            +  + ++S  AKL I+++   + L   E     +P +       +++ +  F++K+    
Sbjct: 1469 RRKKQLESSRAKLQISRDLEDETLWVEER----LPLAQSADYGTNLQTVQLFMKKNQTLQ 1524

Query: 1797 DEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKM 1856
            +E   +   + ++E+VLQRG++++     D +  + RL  L   + +++++         
Sbjct: 1525 NE---ILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHL--QSSWDRLR--------- 1570

Query: 1857 GQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQ 1916
             + A+G    L   +   E  +  L  D+ E  +   EL     E    +E ++  +K  
Sbjct: 1571 -EAAAGRLQRLRDAN---EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRH 1626

Query: 1917 L------DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGC 1970
            L      +  G  I  +  +    +L A  PE  QI     Q++  +  +  +  +RK  
Sbjct: 1627 LRQQRAVEDYGRNIKQLASRAQG-LLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRK 1685

Query: 1971 FDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLD---LEKARIHQQELEVGISS 2027
             +  M    Q   + +DL QWI+E +EL+  +   G   D   L + +      E G + 
Sbjct: 1686 LEN-MYHLFQLKRETDDLEQWISE-KELVASSPEMGQDFDHVTLLRDKFRDFARETG-AI 1742

Query: 2028 HQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVM 2087
             Q     +N   + ++     ++ + + E   GLN+ W A + E+ D + +L   S  + 
Sbjct: 1743 GQERVDNVNAFIERLID-AGHSEAATIAEWKDGLNEMW-ADLLELIDTRMQLLAASYDLH 1800

Query: 2088 KYRHQLDEII 2097
            +Y +   EI+
Sbjct: 1801 RYFYTGAEIL 1810



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 235/1324 (17%), Positives = 507/1324 (38%), Gaps = 187/1324 (14%)

Query: 1540 ERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKA 1599
            E+  QLAR+  ++AA    WLS  +  + Q +    L       +  AK   K  E  + 
Sbjct: 418  EKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA-----VEAAK---KKHEAIET 469

Query: 1600 DLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV-RTWTEDWCNTLMNHQNQ----- 1653
            D     E   AL++L +  E         + A    + R W+  +   L+  + Q     
Sbjct: 470  DTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWS--YLQELLQSRRQRLETT 527

Query: 1654 --LEIFDGNVAHISTWLYQAEALLDEIE-KKPTSKQEEIVKRLVSELDDANLQVENVRDQ 1710
              L+    ++ H   W+ + +A L   E  K   + E+++++   +L +A++ ++  + +
Sbjct: 528  LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK--HKLMEADIAIQGDKVK 585

Query: 1711 ALILMNARGSSSR-------ELVEPKLAELNRNFEKVSQHIKSAKLLIAQEP-LYQCLVT 1762
            A+     + +  +       ++++ +++ L + FE++S      K  + Q   L++    
Sbjct: 586  AITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWE 645

Query: 1763 TETFETGVP-----FSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGE 1817
             +  E+ +      +S L+    D+ ++L    KH    DE   +D   A +E++ Q   
Sbjct: 646  MDEAESWIKEKEQIYSSLD-YGKDLTSVLILQRKHKAFEDELRGLD---AHLEQIFQEAH 701

Query: 1818 EMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYL---V 1874
             M+ +    + + + R++ +    +++++K +    +K  Q A          D L   +
Sbjct: 702  GMVARKQFGHPQIEARIKEV--SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWL 759

Query: 1875 EINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV 1934
            +    LL  +DV             ++DF  + +  + + + L++  +         PDV
Sbjct: 760  QDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDV 819

Query: 1935 ILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITE 1994
                       +R+   Q+ A+ D        R+     A++ +  F  + +    W+ E
Sbjct: 820  THRLQA-----LRELYQQVVAQADL-------RQQRLQEALDLYTVFG-ETDACELWMGE 866

Query: 1995 AEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             E+ L +   P    DLE  +     L+  + +       +N   + +V+         +
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVES-GHPRSREV 925

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTE 2114
            K+    LN RW A    V +R+  +   + +V  Y    +E   W+T     ++  ST +
Sbjct: 926  KQYQDHLNTRWQAFQTLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVE--STKD 982

Query: 2115 LGENL-------QELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPE-RDKISESLRT 2166
            LG +L       ++L  L +++     ++  L R   +++     S PE ++ I +  + 
Sbjct: 983  LGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD----SHPEQKEDIGQRQKH 1038

Query: 2167 VNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEIS 2226
            +   W  + + +    ++ + E S +                +    D       T +  
Sbjct: 1039 LEELWQGLQQSLQGQ-EDLLGEVSQLQ-------------AFLQDLDDFQAWLSITQKAV 1084

Query: 2227 IPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYV 2286
               D+ +++ E        +Q+L+ +     +++    +  R+K +   + Q     +Y+
Sbjct: 1085 ASEDMPESLPEA-------EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYL 1137

Query: 2287 FTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQ-----QLEDMIIDSLQW 2341
              L Q L+   +  +    + E       Q  G Q   +  +Q       ++  +  L+ 
Sbjct: 1138 L-LGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196

Query: 2342 DDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             D  E  E  +RK+E  L  ++  R   L+   S N+++ +                   
Sbjct: 1197 PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE------------------- 1237

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
                G+  +  +KE         + L +    + N    E   +     +L+NFL+  QE
Sbjct: 1238 ----GNLYSDKIKEK--------VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285

Query: 2462 AETTVNVLV----DASHRENALQDSILARELKQQM---QDIQAEIDAHNDIFKSIDGNRQ 2514
                +N  +    D S+ E        AR L  +    Q   AE+ +H    ++ID   +
Sbjct: 1286 LTLWINDKLLTSQDVSYDE--------ARNLHNKWLKHQAFVAELASHEGWLENIDAEGK 1337

Query: 2515 KMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKW 2574
            +++      +   ++  +L+ +++ W++L+A +     HL A A   +  L +  +L KW
Sbjct: 1338 QLMDE--KPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA-ARSSDLRLQTHADLNKW 1394

Query: 2575 LNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEA 2634
            ++  +++L+   P G D+ ++         +  +LK  E  V    ++     A  P   
Sbjct: 1395 ISAMEDQLRSDDP-GKDLTSV-------NRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446

Query: 2635 PEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLR 2694
             E          +L+ E+R   + + + ++    K++ ES  A            L+  R
Sbjct: 1447 EE------GGDADLSIEKRFLDLLEPLGRR----KKQLESSRA-----------KLQISR 1485

Query: 2695 DLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVND 2754
            DL+     ++  +  A+S   G        + ++Q  ++K    + EI     +V+ V  
Sbjct: 1486 DLEDETLWVEERLPLAQSADYGTN------LQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539

Query: 2755 LSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSV 2814
               QL          +  +L  L   W  L+ +   RL++L    RD   + Q++L    
Sbjct: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL----RDANEAQQYYLDADE 1595

Query: 2815 QLPW 2818
               W
Sbjct: 1596 AEAW 1599



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 168/863 (19%), Positives = 339/863 (39%), Gaps = 127/863 (14%)

Query: 340  DDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNA 399
            D +E  +      E F+  +  ++  V S + +GN+L+ +G L  ++   I+E++ L+  
Sbjct: 1198 DSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK---IKEKVQLIED 1254

Query: 400  RWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWLT---LTEERIQKMETCPLDDDVK 454
            R      ++ +    L D L ELQ   +  Q+L+ W+    LT + +         D+ +
Sbjct: 1255 RHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQDVSY-------DEAR 1306

Query: 455  SLQKLLEEHKSLQSDLEAEQVKVNSL-THMVVIVDENSGESATAILEDQLQKLGERWTAV 513
            +L     +H++  ++L + +  + ++      ++DE      TA++  +L+ L   W  +
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP--QFTALVSQKLEALHRLWDEL 1364

Query: 514  CRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRL 573
               T+E+   L          L+    L  W++  E+ L           K+L+   R L
Sbjct: 1365 QATTKEKTQHLSAARSS-DLRLQTHADLNKWISAMEDQLRSDDPG-----KDLTSVNRML 1418

Query: 574  AILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSE-ELTQRWDSLVQRLEDSS 632
            A LK       +  DQ++   +++G+L     +  +   D++  + +R+  L++ L    
Sbjct: 1419 AKLK-------RVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRK 1471

Query: 633  NQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKF 692
             Q+  + AKL +S+  +    ET+ V E+             P  +      +++  + F
Sbjct: 1472 KQLESSRAKLQISRDLED---ETLWVEERL------------PLAQSADYGTNLQTVQLF 1516

Query: 693  DAISAELLNWILKWKTAI--------QTTEIKEYMKMQDTSEMKKKLKALEKEQRE---- 740
               +  L N IL     +        Q  E  E +  QD  E    L++     RE    
Sbjct: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAE-IDCQDLEERLGHLQSSWDRLREAAAG 1575

Query: 741  RIPRADELNQTGQILVEQMGKEG-LPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQED 799
            R+ R  + N+  Q  ++    E  +  +E+  + +++  + +     L+   R+ +  ED
Sbjct: 1576 RLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVED 1635

Query: 800  INAYFKQL------------DELEKVIKTKEEWVKHTS----ISESSRQSLPSLKDSCQ- 842
                 KQL             E E++I+ + +  KH +    ++E  ++ L ++    Q 
Sbjct: 1636 YGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQL 1695

Query: 843  -RELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAV-QEAVEDRQQHL 900
             RE  +L     + E+  AS   +         ++  F  F     A+ QE V++    +
Sbjct: 1696 KRETDDLEQWISEKELV-ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754

Query: 901  ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ 960
            E  +    GH+   T+   KD LN+      +  ++L  +    + L     L       
Sbjct: 1755 ERLIDA--GHSEAATIAEWKDGLNE------MWADLLELIDTRMQLLAASYDLHRYFYTG 1806

Query: 961  KPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRA 1020
               L  + E+ + L ++V  D               ++++     ++LHLL    + ++ 
Sbjct: 1807 AEILGLIDEKHRELPEDVGLDAS---------TAESFHRVHTAFERELHLL---GVQVQQ 1854

Query: 1021 FEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA-------------FVNEIE 1067
            F+  +T ++    G K   + Q   Q   A  Q  LD C+              F +   
Sbjct: 1855 FQDVATRLQTAYAGEKAEAI-QNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913

Query: 1068 TIESSLKNM-KEIETNLRSGPVA----------GIKTWVQTRLGDYQTQLEKLSKEIATQ 1116
             + S ++++ ++IET  R   V+          GI   ++TR  ++   LE     +  Q
Sbjct: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973

Query: 1117 KSRLSESQEKAANLKKDLAEMQE 1139
                 E +EK   +     EM E
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNE 1996



 Score = 45.8 bits (107), Expect = 7e-04
 Identities = 115/626 (18%), Positives = 245/626 (39%), Gaps = 127/626 (20%)

Query: 290  EEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF 349
            +++ ES RA+      ++  DL+   + +EE L    SA        D   +++ V+   
Sbjct: 1471 KKQLESSRAKL-----QISRDLEDETLWVEERLPLAQSA--------DYGTNLQTVQLFM 1517

Query: 350  ATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESM 409
              ++    E+  H   V  VLQ G QL+    +  ++   ++E++  L + W+ LR  + 
Sbjct: 1518 KKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD---LEERLGHLQSSWDRLREAAA 1574

Query: 410  DRQSRLHDVLMELQKKQLQ--QLSAW-----LTLTEERIQKMETC--------------- 447
             R  RL D   E Q+  L   +  AW     L +  + I K E                 
Sbjct: 1575 GRLQRLRDA-NEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAV 1633

Query: 448  ----------------------PLDDDVKSLQKLLEEHKSLQSDLEAEQV-KVNSLTHMV 484
                                  P  + +  LQ  +++H +   D+  E+  K+ ++ H+ 
Sbjct: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693

Query: 485  VIVDENSG--------ESATAILE-----DQLQKLGERWTAVCRWTEE-RWNRLQEINIL 530
             +  E           E   +  E     D +  L +++    R T      R+  +N  
Sbjct: 1694 QLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAF 1753

Query: 531  WQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQL 590
             + L++      A + E ++ LN++    + D  EL  +  +L     D+     T  ++
Sbjct: 1754 IERLIDAGHSEAATIAEWKDGLNEM----WADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809

Query: 591  --------SEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL 642
                     E+ +DVG     +++  ++++  E         VQ+ +D + ++  A A  
Sbjct: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAG- 1868

Query: 643  GMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNW 702
                    +  E ++ +EQ ++  + Q L      ++ Q+ VD   K +F +++ +LL+W
Sbjct: 1869 --------EKAEAIQNKEQEVSA-AWQALLDACAGRRTQL-VDTADKFRFFSMARDLLSW 1918

Query: 703  ILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKE 762
            +      I+T E     + +D S ++  +K  +    E   R+   +   ++    + ++
Sbjct: 1919 MESIIRQIETQE-----RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973

Query: 763  GLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQ---------------- 806
               +EEI+  L++V S  K +++  E    ++++  ++  + +                 
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLA 2033

Query: 807  -------LDELEKVIKTKEEWVKHTS 825
                   +D +EK+IK  E + K T+
Sbjct: 2034 SGDFGHTVDSVEKLIKRHEAFEKSTA 2059


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  281 bits (719), Expect = 8e-75
 Identities = 430/2047 (21%), Positives = 821/2047 (40%), Gaps = 333/2047 (16%)

Query: 22   IKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKE 81
            IK+ +DE   VQKKTFTKW+N+  ++     I D++ DL+DGR L+ LLE L+G  LPK 
Sbjct: 45   IKALADEREVVQKKTFTKWVNSHLARVSCR-ITDLYKDLRDGRMLIKLLEVLSGEMLPKP 103

Query: 82   -RGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVM 140
             +G  R+H L NV++ LQ L +  V L N+G  DIVDGNH+L LGL+W+IIL +Q++D++
Sbjct: 104  TKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIV 163

Query: 141  KDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWD 200
                   +  +++  LL W +  T  Y  VNV NFT+SW DGLAFNA++H+H+PDL  +D
Sbjct: 164  VQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFD 223

Query: 201  KVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQ--- 257
            K+   +    LEHAF+ A+  LGI  LLDPEDV  + PD+KSII Y+ + +    +    
Sbjct: 224  KLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVL 283

Query: 258  --------VTIDAIREVETLPRKYKKECEE---------EAINIQSTAPEEEHESPRAET 300
                      ID   E E +  KY     +           +N +  A        + + 
Sbjct: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343

Query: 301  PSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQ-----------DDISDDVEEVKDQF 349
             ST   V+      +    EVL + + +      Q            DI+   E +++  
Sbjct: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403

Query: 350  ATHEAFMMELTAHQSSVGSVLQAGNQ--LITQGTLSDEEEFEIQEQ-------MTLLNAR 400
               E  +      Q  +  + +  ++   + +  LS+ +    Q+        +     +
Sbjct: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKK 463

Query: 401  WEALRVESM---DRQSRLHDVLMELQKKQLQQ-----------LSAWLTLTE---ERIQK 443
             EA+  ++    +R   L D+  EL+K+               L  W  L E    R Q+
Sbjct: 464  HEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQR 523

Query: 444  METC------------PLD--DDVKS-------------LQKLLEEHKSLQSDLEAEQVK 476
            +ET              +D  D++K+             ++ LL++HK +++D+  +  K
Sbjct: 524  LETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDK 583

Query: 477  VNSLTHMVVIVDENSGESA--TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQEL 534
            V ++T   +   E  G       +++D++  L + +  +      R  +L++   LW + 
Sbjct: 584  VKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLW-KF 642

Query: 535  LEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQ----- 589
              E    ++W+ EKE+  + +     KD   + +  R+    ++++      L+Q     
Sbjct: 643  FWEMDEAESWIKEKEQIYSSLDYG--KDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700

Query: 590  -----------------LSEIGQDVGQLLDNSKASKKINSDSEELTQ---RWDSLVQRLE 629
                             + E+     QL D +   KK   D+E   Q     D L   L+
Sbjct: 701  HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQ 760

Query: 630  D-----SSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKK----- 679
            D     S   V Q            KD LE +    + + +  +Q+    P   +     
Sbjct: 761  DAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-ESRGVMEHLEQQAQGFPEEFRDSPDV 819

Query: 680  -------RQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTE-----IKEYMKMQDTSEM 727
                   R+++  + A+     +  + L   L   T    T+     + E  K     EM
Sbjct: 820  THRLQALRELYQQVVAQAD---LRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEM 876

Query: 728  KKKLKALEKEQRERIPRADELNQTGQILVEQMG----------KEGLP-TEEIKNVLEKV 776
               L+ LE  Q     R D L+Q  + L+ Q+           + G P + E+K   + +
Sbjct: 877  PDTLEDLEVVQH----RFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHL 932

Query: 777  SSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPS 836
            ++ W+     + +    +     ++ Y    +E  K I  K      T + ES++     
Sbjct: 933  NTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDK------TKVVESTK----- 981

Query: 837  LKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDR 896
                  R+L  ++ +  K+       +A+ ++    D ++R     +  +   +E +  R
Sbjct: 982  ---DLGRDLAGIIAIQRKLSGLERDVAAIQAR---VDALERESQQLMDSHPEQKEDIGQR 1035

Query: 897  QQHLE-------NELKGQPG--------HAYLETLKTLKDVLNDSENKAQVSLNVLNDLA 941
            Q+HLE         L+GQ           A+L+ L   +  L+ ++ KA  S ++   L 
Sbjct: 1036 QKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMPESLP 1094

Query: 942  KVEKALQEKKTLDEILENQKPALHKLAEE-TKALEKNVHPDVEKLYKQEFDDVQGKWNKL 1000
            + E+ LQ+   + + ++  + +  ++ E   K ++    P+   L  Q  + +   WN L
Sbjct: 1095 EAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEY-LLLGQRLEGLDTGWNAL 1153

Query: 1001 KVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCS 1060
              +     H L +  L  + F+ D+   E  +   +  L   +            L+   
Sbjct: 1154 GRMWESRSHTLAQ-CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPD--------SLEAAE 1204

Query: 1061 AFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
            A + + E    S++N ++    + S   +G K   +  L  Y  ++++  + I  +  + 
Sbjct: 1205 AGIRKFEDFLGSMENNRD---KVLSPVDSGNKLVAEGNL--YSDKIKEKVQLIEDRHRKN 1259

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYL--------ERDFEYKSPEELESAVEEMKRAK 1172
            +E  ++A+ L +D  E+Q ++   +E  L         +D  Y     L +   + +   
Sbjct: 1260 NEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV 1319

Query: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
             ++   E  ++ +    K L  + P     ++ +L  +   +  L    + K   L    
Sbjct: 1320 AELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAAR 1379

Query: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIR- 1291
            S  + L  + DL   W++ +E++++S +   + T +VN  L  L+ V     +++  +R 
Sbjct: 1380 SSDLRLQTHADL-NKWISAMEDQLRSDDPGKDLT-SVNRMLAKLKRV-----EDQVNVRK 1432

Query: 1292 -ELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEK---QLQVLRETDQMLQ 1347
             ELG+       + +   +   +   R+ DL      ++  LE    +LQ+ R+ +    
Sbjct: 1433 EELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETL 1492

Query: 1348 VLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPE 1407
             ++E L     Q   Y T+        ++ Q +Q EI  H   +E++ +  R Q L    
Sbjct: 1493 WVEERLPL--AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ--RGQQLVEAA 1548

Query: 1408 SRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVD 1467
                +       L+ +L  + + +   ++ A         +R+ D  +A+ + LD  + +
Sbjct: 1549 EIDCQD------LEERLGHLQSSWDRLREAAAGR-----LQRLRDANEAQQYYLDADEAE 1597

Query: 1468 PDVIQTHLDKCMKLYKTLSEV-KLEVETVIKTGRHIVQ-----------KQQTDNPKGM- 1514
              + +       +LY    E+ K E   ++   RH+ Q           KQ     +G+ 
Sbjct: 1598 AWIGE------QELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLL 1651

Query: 1515 ------DEQLTSLK----VLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564
                   EQ+  L+      Y  L     E K+ LE    L  ++K+E   L +W+S  E
Sbjct: 1652 SAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF-QLKRETDDLEQWIS--E 1708

Query: 1565 TELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEE 1624
             ELV  S   G   D D  ++  ++  +D  +         E+ A  Q  ++     +E 
Sbjct: 1709 KELVASSPEMG--QDFD-HVTLLRDKFRDFAR---------ETGAIGQERVDNVNAFIER 1756

Query: 1625 RLCVLNAGWSRVRT---W----TEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDE 1677
               +++AG S   T   W     E W + L     ++++   +   +  + Y    +L  
Sbjct: 1757 ---LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY-DLHRYFYTGAEILGL 1812

Query: 1678 IEKKPTSKQEE-------------IVKRLVSELDDANLQVENVRDQALILMNARGSSSRE 1724
            I++K     E+             +      EL    +QV+  +D A  L  A      E
Sbjct: 1813 IDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872

Query: 1725 LVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIEN 1784
             ++ K  E++  ++ +       +         Q + T + F     FS    L + +E+
Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRT--------QLVDTADKFRF---FSMARDLLSWMES 1921

Query: 1785 MLKFVEKHLESSDE-------------DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEK 1831
            +++ +E      D              + +++  S      L+ GE +L +  + +++ +
Sbjct: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981

Query: 1832 IRLQLLL 1838
             +LQ ++
Sbjct: 1982 EKLQQVM 1988



 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 288/1573 (18%), Positives = 602/1573 (38%), Gaps = 223/1573 (14%)

Query: 1299 DGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQL-------QVLRETDQMLQVLQE 1351
            DG ++ DI        N  +E L      ++++L  +L       Q+ R  D+   + + 
Sbjct: 385  DGKLVSDI--------NRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRET 436

Query: 1352 SLGELDKQLTT----YLTDRIDAFQVPQEAQKIQAEISAHE---LTLEELRRNMRSQPLT 1404
             L E  + +      Y    ++A +   EA  I+ + +A+E     LE+L + +  +   
Sbjct: 437  WLSENQRLVAQDNFGYDLAAVEAAKKKHEA--IETDTAAYEERVRALEDLAQELEKENYH 494

Query: 1405 SPESRTARGGSQMDV---LQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAEL--- 1458
              +  TAR  + + +   LQ  L+    + +         Q ML     +D +KA L   
Sbjct: 495  DQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSA 554

Query: 1459 ----HVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGM 1514
                H+L+V+D+    +Q H  K M+    +   K++  T         +  Q  +P+ +
Sbjct: 555  EFGKHLLEVEDL----LQKH--KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVI 608

Query: 1515 DEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSE 1574
             ++++ L+  + +L       K  LE++ +L  K   E      W+   E E +  S   
Sbjct: 609  QDRISHLEQCFEELSNMAAGRKAQLEQSKRLW-KFFWEMDEAESWIK--EKEQIYSSLDY 665

Query: 1575 GLLGDLDTEISWA---KNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNA 1631
            G   DL + +      K    +L    A L  I + +  +    +   P +E R+  ++A
Sbjct: 666  GK--DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSA 723

Query: 1632 GWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALL-------DEIEKKPTS 1684
             W +++         L + +N  + F G+   +  WL  A  LL       DE   +   
Sbjct: 724  QWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALG 782

Query: 1685 KQEEIVKRLVSELDDANLQVENVRDQALIL---------MNARGSSSRELVEPKLAELNR 1735
            K+    K  + EL+++   +E++  QA            +  R  + REL +  +A+ + 
Sbjct: 783  KKH---KDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADL 839

Query: 1736 NFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLES 1795
              +++ + +           LY     T+  E  +   +    E ++ + L+ +E     
Sbjct: 840  RQQRLQEALD----------LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHR 889

Query: 1796 SDE-DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR 1854
             D  D++M     QI+ V      ++       +  +++     L+TR+   + +  ++R
Sbjct: 890  FDILDQEMKTLMTQIDGVNLAANSLVESGHP--RSREVKQYQDHLNTRWQAFQTLVSERR 947

Query: 1855 KMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIK 1914
            +       + S+L   +Y V+  +    + D      V E    +  D +     +  I+
Sbjct: 948  E------AVDSALRVHNYCVDCEETSKWITD---KTKVVESTKDLGRDLA----GIIAIQ 994

Query: 1915 DQLDKLGEQIAVIH------EKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRK 1968
             +L  L   +A I       E++   ++++   +   I      L   W  + +    ++
Sbjct: 995  RKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQE 1054

Query: 1969 GCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSH 2028
                  + + + F  DL+D   W++  ++ +     P    + E+       ++  I  H
Sbjct: 1055 DLLGE-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGH 1113

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMK 2088
            Q S+  +  +G+ ++Q  +  +   L ++L GL+  W+A+    + R   L  +     +
Sbjct: 1114 QDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL-AQCLGFQE 1172

Query: 2089 YRHQLDEIICWLTKAEHA---MQKRSTTELGE-NLQELRDLTQEMEVHAEKLKWLNRTEL 2144
            ++    +    L+  E+    ++   + E  E  +++  D    ME + +K+     +  
Sbjct: 1173 FQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGN 1232

Query: 2145 EMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQ 2204
            +++++ +L     DKI E ++ +     K          E  QE S + +  +     +Q
Sbjct: 1233 KLVAEGNL---YSDKIKEKVQLIEDRHRK--------NNEKAQEASVLLRDNLELQNFLQ 1281

Query: 2205 KVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINK 2264
                                            EL  W  + D++L S  V+  +   ++ 
Sbjct: 1282 -----------------------------NCQELTLW--INDKLLTSQDVSYDEARNLHN 1310

Query: 2265 TVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGV 2324
               + +   A+L      L+ +    + L ++         +++KLE +   WD  Q   
Sbjct: 1311 KWLKHQAFVAELASHEGWLENIDAEGKQLMDE--KPQFTALVSQKLEALHRLWDELQATT 1368

Query: 2325 ELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQEL 2384
            + + Q L      + +  D R +T   + K+ + +    Q R D   K ++    +L +L
Sbjct: 1369 KEKTQHL-----SAARSSDLRLQTHADLNKWISAME--DQLRSDDPGKDLTSVNRMLAKL 1421

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
               +  V      L +L  +  S       +    ++  +++L + +  R+  LE+    
Sbjct: 1422 KRVEDQVNVRKEELGELFAQVPSMGEEG-GDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480

Query: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
            +Q S RDLE+   W++E       L  ++     LQ   L     ++ Q +Q EI  H  
Sbjct: 1481 LQIS-RDLEDETLWVEERLP----LAQSADYGTNLQTVQL---FMKKNQTLQNEILGHTP 1532

Query: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
              + +    Q++V+A     +   L+ RL  +   W+ L+ ++A+ R      A +  + 
Sbjct: 1533 RVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRLR-EAAAGRLQRLRDANEAQQY 1589

Query: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
             +  +E   W+   ++EL     I  ++P                K++E     A+   +
Sbjct: 1590 YLDADEAEAWIG--EQEL---YVISDEIP----------------KDEE----GAIVMLK 1624

Query: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKA-------MRKQSSEVKEKWESLNA 2677
              L  Q   A E+  RN++         RAQ +  A       + +   +V + +  L  
Sbjct: 1625 RHLRQQ--RAVEDYGRNIKQLA-----SRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKD 1677

Query: 2678 VTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGD-----LLIDSLQDHI 2732
            V    +++++  +  L  L+   DDL+  + E E V +  +   D     LL D  +D  
Sbjct: 1678 VAEERKRKLEN-MYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFA 1736

Query: 2733 EKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRL 2792
             +  A  +E      +V  VN    +L       +  ++   D LN  W  L   +D R+
Sbjct: 1737 RETGAIGQE------RVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRM 1790

Query: 2793 KQL---QEAHRDF 2802
            + L    + HR F
Sbjct: 1791 QLLAASYDLHRYF 1803



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 253/1334 (18%), Positives = 499/1334 (37%), Gaps = 173/1334 (12%)

Query: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLND---SENKAQVSL-NVLNDLA 941
            +++++EA   R+  L NEL  Q     L      K  + +   SEN+  V+  N   DLA
Sbjct: 396  WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455

Query: 942  KVEKALQEKKTLDE---ILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWN 998
             VE A ++ + ++      E +  AL  LA+E   LEK  + D +++  ++ D++   W+
Sbjct: 456  AVEAAKKKHEAIETDTAAYEERVRALEDLAQE---LEKENYHDQKRITARK-DNILRLWS 511

Query: 999  KLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQR 1054
             L+ L+      LE   L L+    D      WMD +K  L+  +  +     +D   + 
Sbjct: 512  YLQELLQSRRQRLET-TLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570

Query: 1055 QLDQCSAFV--NEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKE 1112
            +L +    +  ++++ I ++     E +      P       +Q R+   +   E+LS  
Sbjct: 571  KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQV-----IQDRISHLEQCFEELSNM 625

Query: 1113 IATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAK 1172
             A +K++L +S+ +      ++ E + W+ + E+ Y   D+       L   ++   +A 
Sbjct: 626  AAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL--ILQRKHKAF 682

Query: 1173 EDVLQK-EVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEV 1231
            ED L+  +  ++ +      + A+   G  ++ + +  V   +  L +        L++ 
Sbjct: 683  EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742

Query: 1232 WSCWIELLHYLDLETTWLNTLEERMK---------STEVLPEKTDAVNEALESLESVLRH 1282
             + + +     D    WL      +          +T  L +K     E LE    V+ H
Sbjct: 743  EN-FFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEH 801

Query: 1283 PADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQ---VL 1339
                     E  +   D       ++ +L+A    Y+ +   A+ +Q  L++ L    V 
Sbjct: 802  LEQQAQGFPEEFRDSPD-------VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVF 854

Query: 1340 RETDQMLQVLQESLGELDKQLTTY-LTDRIDAFQV--------PQEAQKIQAEISAHELT 1390
             ETD      +  +GE +K L    + D ++  +V         QE + +  +I    L 
Sbjct: 855  GETD----ACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLA 910

Query: 1391 LEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLRE----VSTKFQLFQKPANFEQRMLD 1446
               L  +        P SR  +     D L  + +     VS + +            +D
Sbjct: 911  ANSLVESGH------PRSREVK--QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD 962

Query: 1447 CKRVLDGVKAELHVLD-VKDVDPDV--IQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIV 1503
            C+     +  +  V++  KD+  D+  I     K   L + ++ ++  V+ + +  + ++
Sbjct: 963  CEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLM 1022

Query: 1504 QKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSAT 1563
                 +  + + ++   L+ L+  L  Q  +G++DL       +   ++      WLS T
Sbjct: 1023 DSHP-EQKEDIGQRQKHLEELWQGL-QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080

Query: 1564 ETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSA-ALQNLIEGSEPIL 1622
            +  +  +   E L  + +  +     +  +++  +     + ES    +Q   +    +L
Sbjct: 1081 QKAVASEDMPESL-PEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLL 1139

Query: 1623 EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKP 1682
             +RL  L+ GW+ +    E   +TL       E F  +       L   E  L  +E   
Sbjct: 1140 GQRLEGLDTGWNALGRMWESRSHTLAQCLGFQE-FQKDAKQAEAILSNQEYTLAHLEPPD 1198

Query: 1683 TSKQEEIVKRLVSELDDANLQVENVRDQALILMN------ARGSSSRELVEPKLAELNRN 1736
            + +  E   R   + +D    +EN RD+ L  ++      A G+   + ++ K+  +   
Sbjct: 1199 SLEAAEAGIR---KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDR 1255

Query: 1737 FEKVSQHIKSAKLLIA-----QEPLYQCLVTTETFET------GVPFSDLEKLENDIENM 1785
              K ++  + A +L+      Q  L  C   T            V + +   L N     
Sbjct: 1256 HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKH 1315

Query: 1786 LKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNK 1845
              FV +        E +D E  Q+ +   +   ++ Q +E             LH  +++
Sbjct: 1316 QAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLE------------ALHRLWDE 1363

Query: 1846 IKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSF 1905
            ++A     ++  Q  S  RSS L      ++NK +  M+D   S +  +  T++    + 
Sbjct: 1364 LQATT---KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLA- 1419

Query: 1906 QEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYS 1965
                LK ++DQ++   E++  +  + P +  E    +    +  L  L     R  ++ S
Sbjct: 1420 ---KLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLES 1476

Query: 1966 DRKGCFDRAMEEWRQFHCDLNDLTQWITEA---------------------------EEL 1998
             R            Q   DL D T W+ E                             E+
Sbjct: 1477 SRAKL---------QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527

Query: 1999 L-----VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSF 2053
            L     V+     G   +E A I  Q+LE  +   Q S+  L     G +Q+L  A+   
Sbjct: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDAN--- 1584

Query: 2054 LKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT 2113
                        DA  AE    +  L   S ++ K     DE    +    H  Q+R+  
Sbjct: 1585 -----EAQQYYLDADEAEAWIGEQELYVISDEIPK-----DEEGAIVMLKRHLRQQRAVE 1634

Query: 2114 ELGENLQELRDLTQ 2127
            + G N+++L    Q
Sbjct: 1635 DYGRNIKQLASRAQ 1648



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 280/1450 (19%), Positives = 567/1450 (39%), Gaps = 180/1450 (12%)

Query: 728  KKKLKALEKEQ---RERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVS 784
            KKK +A+E +     ER+   ++L Q  ++  E    +   T    N+L   S   + + 
Sbjct: 461  KKKHEAIETDTAAYEERVRALEDLAQ--ELEKENYHDQKRITARKDNILRLWSYLQELLQ 518

Query: 785  QHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRE 844
               + LE  + LQ+        +D ++++         H   +E  +  L         E
Sbjct: 519  SRRQRLETTLALQKLFQDMLHSIDWMDEI-------KAHLLSAEFGKHLL---------E 562

Query: 845  LTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLEN-- 902
            + +LL  H  +E   A  +    +  A       F    G      + ++DR  HLE   
Sbjct: 563  VEDLLQKHKLME---ADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCF 619

Query: 903  -ELKGQPG--HAYLETLKTLKDV---LNDSEN----KAQV--SLNVLNDLAKVEKALQEK 950
             EL        A LE  K L      ++++E+    K Q+  SL+   DL  V    ++ 
Sbjct: 620  EELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH 679

Query: 951  KTLDEILENQKPALHKLAEETKAL---EKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKD 1007
            K  ++ L      L ++ +E   +   ++  HP +E   K+    V  +W++LK L +  
Sbjct: 680  KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE----VSAQWDQLKDLAAFC 735

Query: 1008 LHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIE 1067
               L++ A     F+ D+  ++ W+      L  +    G D G  R L +     + +E
Sbjct: 736  KKNLQD-AENFFQFQGDADDLKAWLQDAHRLLSGEDV--GQDEGATRALGK--KHKDFLE 790

Query: 1068 TIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQ-LEKLSKEIATQKSRLSESQEK 1126
             +E S   M+ +E   +  P    + +  +    ++ Q L +L +++  Q     +  ++
Sbjct: 791  ELEESRGVMEHLEQQAQGFP----EEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846

Query: 1127 AANLKKDLAEMQE---WMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVK 1183
            A +L     E      WM + E+   E +     P+ LE    E+ + + D+L +E++  
Sbjct: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEM----PDTLEDL--EVVQHRFDILDQEMKTL 900

Query: 1184 ILK-DNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY- 1241
            + + D + L A  +   G   + E+    ++        +       E     + + +Y 
Sbjct: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960

Query: 1242 LDLETT--WLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLID 1299
            +D E T  W+    + ++ST+ L      +      L  + R  A  + ++  L +   +
Sbjct: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALER---E 1017

Query: 1300 GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQ 1359
               L D   E+ E    R + L  L +  Q SL+ Q  +L E  Q+   LQ+     D Q
Sbjct: 1018 SQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLD---DFQ 1074

Query: 1360 LTTYLTDRI-----------DAFQVPQEAQKIQAEISAHELTLEELRRNMRS--QPLTSP 1406
                +T +            +A Q+ Q+   I+ EI  H+ + + ++ +     Q  T P
Sbjct: 1075 AWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134

Query: 1407 E-----SRTARGGSQMDVLQRKLREVSTK------FQLFQKPANFEQRMLDCKRVLDGVK 1455
            E      R     +  + L R     S        FQ FQK A         + +L   +
Sbjct: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK------QAEAILSNQE 1188

Query: 1456 AELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMD 1515
              L  L+  D   +  +  + K      ++   + +V + + +G  +V +    + K + 
Sbjct: 1189 YTLAHLEPPD-SLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-IK 1246

Query: 1516 EQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEG 1575
            E++  ++  +     +  E    L    +L +   +    L+ W++            + 
Sbjct: 1247 EKVQLIEDRHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLWIN------------DK 1293

Query: 1576 LLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEER---------- 1625
            LL   D     A+N+     K +A +  +      L+N+    + +++E+          
Sbjct: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353

Query: 1626 LCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSK 1685
            L  L+  W  ++  T++    L   ++  ++     A ++ W+    A+ D++      K
Sbjct: 1354 LEALHRLWDELQATTKEKTQHLSAARSS-DLRLQTHADLNKWI---SAMEDQLRSDDPGK 1409

Query: 1686 QEEIVKRLVSELDDANLQVENVRDQAL-------ILMNARGSSSRELVEPKLAELNRNFE 1738
                V R++++L     QV NVR + L         M   G  +   +E +  +L     
Sbjct: 1410 DLTSVNRMLAKLKRVEDQV-NVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLG 1468

Query: 1739 KVSQHIKS--AKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESS 1796
            +  + ++S  AKL I+++   + L   E     +P +       +++ +  F++K+    
Sbjct: 1469 RRKKQLESSRAKLQISRDLEDETLWVEER----LPLAQSADYGTNLQTVQLFMKKNQTLQ 1524

Query: 1797 DEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKM 1856
            +E   +   + ++E+VLQRG++++     D +  + RL  L   + +++++         
Sbjct: 1525 NE---ILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHL--QSSWDRLR--------- 1570

Query: 1857 GQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQ 1916
             + A+G    L   +   E  +  L  D+ E  +   EL     E    +E ++  +K  
Sbjct: 1571 -EAAAGRLQRLRDAN---EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRH 1626

Query: 1917 L------DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGC 1970
            L      +  G  I  +  +    +L A  PE  QI     Q++  +  +  +  +RK  
Sbjct: 1627 LRQQRAVEDYGRNIKQLASRAQG-LLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRK 1685

Query: 1971 FDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLD---LEKARIHQQELEVGISS 2027
             +  M    Q   + +DL QWI+E +EL+  +   G   D   L + +      E G + 
Sbjct: 1686 LEN-MYHLFQLKRETDDLEQWISE-KELVASSPEMGQDFDHVTLLRDKFRDFARETG-AI 1742

Query: 2028 HQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVM 2087
             Q     +N   + ++     ++ + + E   GLN+ W A + E+ D + +L   S  + 
Sbjct: 1743 GQERVDNVNAFIERLID-AGHSEAATIAEWKDGLNEMW-ADLLELIDTRMQLLAASYDLH 1800

Query: 2088 KYRHQLDEII 2097
            +Y +   EI+
Sbjct: 1801 RYFYTGAEIL 1810



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 235/1324 (17%), Positives = 507/1324 (38%), Gaps = 187/1324 (14%)

Query: 1540 ERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKA 1599
            E+  QLAR+  ++AA    WLS  +  + Q +    L       +  AK   K  E  + 
Sbjct: 418  EKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA-----VEAAK---KKHEAIET 469

Query: 1600 DLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV-RTWTEDWCNTLMNHQNQ----- 1653
            D     E   AL++L +  E         + A    + R W+  +   L+  + Q     
Sbjct: 470  DTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWS--YLQELLQSRRQRLETT 527

Query: 1654 --LEIFDGNVAHISTWLYQAEALLDEIE-KKPTSKQEEIVKRLVSELDDANLQVENVRDQ 1710
              L+    ++ H   W+ + +A L   E  K   + E+++++   +L +A++ ++  + +
Sbjct: 528  LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK--HKLMEADIAIQGDKVK 585

Query: 1711 ALILMNARGSSSR-------ELVEPKLAELNRNFEKVSQHIKSAKLLIAQEP-LYQCLVT 1762
            A+     + +  +       ++++ +++ L + FE++S      K  + Q   L++    
Sbjct: 586  AITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWE 645

Query: 1763 TETFETGVP-----FSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGE 1817
             +  E+ +      +S L+    D+ ++L    KH    DE   +D   A +E++ Q   
Sbjct: 646  MDEAESWIKEKEQIYSSLD-YGKDLTSVLILQRKHKAFEDELRGLD---AHLEQIFQEAH 701

Query: 1818 EMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYL---V 1874
             M+ +    + + + R++ +    +++++K +    +K  Q A          D L   +
Sbjct: 702  GMVARKQFGHPQIEARIKEV--SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWL 759

Query: 1875 EINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV 1934
            +    LL  +DV             ++DF  + +  + + + L++  +         PDV
Sbjct: 760  QDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDV 819

Query: 1935 ILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITE 1994
                       +R+   Q+ A+ D        R+     A++ +  F  + +    W+ E
Sbjct: 820  THRLQA-----LRELYQQVVAQADL-------RQQRLQEALDLYTVFG-ETDACELWMGE 866

Query: 1995 AEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFL 2054
             E+ L +   P    DLE  +     L+  + +       +N   + +V+         +
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVES-GHPRSREV 925

Query: 2055 KEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTE 2114
            K+    LN RW A    V +R+  +   + +V  Y    +E   W+T     ++  ST +
Sbjct: 926  KQYQDHLNTRWQAFQTLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVE--STKD 982

Query: 2115 LGENL-------QELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPE-RDKISESLRT 2166
            LG +L       ++L  L +++     ++  L R   +++     S PE ++ I +  + 
Sbjct: 983  LGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD----SHPEQKEDIGQRQKH 1038

Query: 2167 VNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEIS 2226
            +   W  + + +    ++ + E S +                +    D       T +  
Sbjct: 1039 LEELWQGLQQSLQGQ-EDLLGEVSQLQ-------------AFLQDLDDFQAWLSITQKAV 1084

Query: 2227 IPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYV 2286
               D+ +++ E        +Q+L+ +     +++    +  R+K +   + Q     +Y+
Sbjct: 1085 ASEDMPESLPEA-------EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYL 1137

Query: 2287 FTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQ-----QLEDMIIDSLQW 2341
              L Q L+   +  +    + E       Q  G Q   +  +Q       ++  +  L+ 
Sbjct: 1138 L-LGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196

Query: 2342 DDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKL 2401
             D  E  E  +RK+E  L  ++  R   L+   S N+++ +                   
Sbjct: 1197 PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE------------------- 1237

Query: 2402 LEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQE 2461
                G+  +  +KE         + L +    + N    E   +     +L+NFL+  QE
Sbjct: 1238 ----GNLYSDKIKEK--------VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285

Query: 2462 AETTVNVLV----DASHRENALQDSILARELKQQM---QDIQAEIDAHNDIFKSIDGNRQ 2514
                +N  +    D S+ E        AR L  +    Q   AE+ +H    ++ID   +
Sbjct: 1286 LTLWINDKLLTSQDVSYDE--------ARNLHNKWLKHQAFVAELASHEGWLENIDAEGK 1337

Query: 2515 KMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKW 2574
            +++      +   ++  +L+ +++ W++L+A +     HL A A   +  L +  +L KW
Sbjct: 1338 QLMDE--KPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA-ARSSDLRLQTHADLNKW 1394

Query: 2575 LNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEA 2634
            ++  +++L+   P G D+ ++         +  +LK  E  V    ++     A  P   
Sbjct: 1395 ISAMEDQLRSDDP-GKDLTSV-------NRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446

Query: 2635 PEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLR 2694
             E          +L+ E+R   + + + ++    K++ ES  A            L+  R
Sbjct: 1447 EE------GGDADLSIEKRFLDLLEPLGRR----KKQLESSRA-----------KLQISR 1485

Query: 2695 DLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVND 2754
            DL+     ++  +  A+S   G        + ++Q  ++K    + EI     +V+ V  
Sbjct: 1486 DLEDETLWVEERLPLAQSADYGTN------LQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539

Query: 2755 LSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSV 2814
               QL          +  +L  L   W  L+ +   RL++L    RD   + Q++L    
Sbjct: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL----RDANEAQQYYLDADE 1595

Query: 2815 QLPW 2818
               W
Sbjct: 1596 AEAW 1599



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 168/863 (19%), Positives = 339/863 (39%), Gaps = 127/863 (14%)

Query: 340  DDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNA 399
            D +E  +      E F+  +  ++  V S + +GN+L+ +G L  ++   I+E++ L+  
Sbjct: 1198 DSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK---IKEKVQLIED 1254

Query: 400  RWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWLT---LTEERIQKMETCPLDDDVK 454
            R      ++ +    L D L ELQ   +  Q+L+ W+    LT + +         D+ +
Sbjct: 1255 RHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQDVSY-------DEAR 1306

Query: 455  SLQKLLEEHKSLQSDLEAEQVKVNSL-THMVVIVDENSGESATAILEDQLQKLGERWTAV 513
            +L     +H++  ++L + +  + ++      ++DE      TA++  +L+ L   W  +
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP--QFTALVSQKLEALHRLWDEL 1364

Query: 514  CRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRL 573
               T+E+   L          L+    L  W++  E+ L           K+L+   R L
Sbjct: 1365 QATTKEKTQHLSAARSS-DLRLQTHADLNKWISAMEDQLRSDDPG-----KDLTSVNRML 1418

Query: 574  AILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSE-ELTQRWDSLVQRLEDSS 632
            A LK       +  DQ++   +++G+L     +  +   D++  + +R+  L++ L    
Sbjct: 1419 AKLK-------RVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRK 1471

Query: 633  NQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKF 692
             Q+  + AKL +S+  +    ET+ V E+             P  +      +++  + F
Sbjct: 1472 KQLESSRAKLQISRDLED---ETLWVEERL------------PLAQSADYGTNLQTVQLF 1516

Query: 693  DAISAELLNWILKWKTAI--------QTTEIKEYMKMQDTSEMKKKLKALEKEQRE---- 740
               +  L N IL     +        Q  E  E +  QD  E    L++     RE    
Sbjct: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAE-IDCQDLEERLGHLQSSWDRLREAAAG 1575

Query: 741  RIPRADELNQTGQILVEQMGKEG-LPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQED 799
            R+ R  + N+  Q  ++    E  +  +E+  + +++  + +     L+   R+ +  ED
Sbjct: 1576 RLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVED 1635

Query: 800  INAYFKQL------------DELEKVIKTKEEWVKHTS----ISESSRQSLPSLKDSCQ- 842
                 KQL             E E++I+ + +  KH +    ++E  ++ L ++    Q 
Sbjct: 1636 YGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQL 1695

Query: 843  -RELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAV-QEAVEDRQQHL 900
             RE  +L     + E+  AS   +         ++  F  F     A+ QE V++    +
Sbjct: 1696 KRETDDLEQWISEKELV-ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754

Query: 901  ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ 960
            E  +    GH+   T+   KD LN+      +  ++L  +    + L     L       
Sbjct: 1755 ERLIDA--GHSEAATIAEWKDGLNE------MWADLLELIDTRMQLLAASYDLHRYFYTG 1806

Query: 961  KPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRA 1020
               L  + E+ + L ++V  D               ++++     ++LHLL    + ++ 
Sbjct: 1807 AEILGLIDEKHRELPEDVGLDAS---------TAESFHRVHTAFERELHLL---GVQVQQ 1854

Query: 1021 FEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA-------------FVNEIE 1067
            F+  +T ++    G K   + Q   Q   A  Q  LD C+              F +   
Sbjct: 1855 FQDVATRLQTAYAGEKAEAI-QNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913

Query: 1068 TIESSLKNM-KEIETNLRSGPVA----------GIKTWVQTRLGDYQTQLEKLSKEIATQ 1116
             + S ++++ ++IET  R   V+          GI   ++TR  ++   LE     +  Q
Sbjct: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973

Query: 1117 KSRLSESQEKAANLKKDLAEMQE 1139
                 E +EK   +     EM E
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNE 1996



 Score = 45.8 bits (107), Expect = 7e-04
 Identities = 115/626 (18%), Positives = 245/626 (39%), Gaps = 127/626 (20%)

Query: 290  EEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF 349
            +++ ES RA+      ++  DL+   + +EE L    SA        D   +++ V+   
Sbjct: 1471 KKQLESSRAKL-----QISRDLEDETLWVEERLPLAQSA--------DYGTNLQTVQLFM 1517

Query: 350  ATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESM 409
              ++    E+  H   V  VLQ G QL+    +  ++   ++E++  L + W+ LR  + 
Sbjct: 1518 KKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD---LEERLGHLQSSWDRLREAAA 1574

Query: 410  DRQSRLHDVLMELQKKQLQ--QLSAW-----LTLTEERIQKMETC--------------- 447
             R  RL D   E Q+  L   +  AW     L +  + I K E                 
Sbjct: 1575 GRLQRLRDA-NEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAV 1633

Query: 448  ----------------------PLDDDVKSLQKLLEEHKSLQSDLEAEQV-KVNSLTHMV 484
                                  P  + +  LQ  +++H +   D+  E+  K+ ++ H+ 
Sbjct: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693

Query: 485  VIVDENSG--------ESATAILE-----DQLQKLGERWTAVCRWTEE-RWNRLQEINIL 530
             +  E           E   +  E     D +  L +++    R T      R+  +N  
Sbjct: 1694 QLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAF 1753

Query: 531  WQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQL 590
             + L++      A + E ++ LN++    + D  EL  +  +L     D+     T  ++
Sbjct: 1754 IERLIDAGHSEAATIAEWKDGLNEM----WADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809

Query: 591  --------SEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL 642
                     E+ +DVG     +++  ++++  E         VQ+ +D + ++  A A  
Sbjct: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAG- 1868

Query: 643  GMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNW 702
                    +  E ++ +EQ ++  + Q L      ++ Q+ VD   K +F +++ +LL+W
Sbjct: 1869 --------EKAEAIQNKEQEVSA-AWQALLDACAGRRTQL-VDTADKFRFFSMARDLLSW 1918

Query: 703  ILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKE 762
            +      I+T E     + +D S ++  +K  +    E   R+   +   ++    + ++
Sbjct: 1919 MESIIRQIETQE-----RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973

Query: 763  GLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQ---------------- 806
               +EEI+  L++V S  K +++  E    ++++  ++  + +                 
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLA 2033

Query: 807  -------LDELEKVIKTKEEWVKHTS 825
                   +D +EK+IK  E + K T+
Sbjct: 2034 SGDFGHTVDSVEKLIKRHEAFEKSTA 2059


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  281 bits (719), Expect = 8e-75
 Identities = 587/2791 (21%), Positives = 1083/2791 (38%), Gaps = 418/2791 (14%)

Query: 15   QNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLT 74
            QNE S +     DE + VQKKTFTKW+N    K+ +  I+D++ DL+DG  L+ LLE L+
Sbjct: 8    QNEISSL----KDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISLLEVLS 62

Query: 75   GTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHW 134
            G SLP+E+G  R H L NV   L  L    V+LVNI   DI DGN KLTLGL+W+IILH+
Sbjct: 63   GDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHF 122

Query: 135  QVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKP 194
            Q+ D+     S+   T  EK+LL W ++    Y  +   NFT+SW DG  FNA++HRHKP
Sbjct: 123  QISDIQVSGQSE-DMTAKEKLLL-WSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180

Query: 195  DLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVL 254
             L   +KV + + +E L+ AFS A+  LG+ +LLDPEDV V  PD+KSII Y++SL++ +
Sbjct: 181  LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240

Query: 255  PQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSY 314
            P+                                       P  +      E+ +    Y
Sbjct: 241  PR--------------------------------------VPDVQDGVRANELQLRWQEY 262

Query: 315  QIALEEVLTWLLSAEDTFQEQDDIS--DDVEEVKDQFATHEAFMMELTAHQS-------- 364
            +  +  +L W+      F+E+   S  +++E +  QF   +   MEL A ++        
Sbjct: 263  RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE--MELPAKEADKNRSKGI 320

Query: 365  --SVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--M 420
              S+   +QAG   +  G    + E E           W  L V  ++R+ +L      +
Sbjct: 321  YQSLEGAVQAGQLKVPPGYHPLDVEKE-----------WGKLHVAILEREKQLRSEFERL 369

Query: 421  ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQ--KLLEEHKSLQSDLEAEQVKVN 478
            E  ++ + +L     L EE++ + +   L  DV+ L   K+ +    ++ DL+     + 
Sbjct: 370  ECLQRIVTKLQMEAGLCEEQLNQADAL-LQSDVRLLAAGKVPQRAGEVERDLDKADSMIR 428

Query: 479  SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQ 538
             L + V  + +        +   ++ +L ER  A+                      E  
Sbjct: 429  LLFNDVQTLKDGRHPQGEQMYR-RVYRLHERLVAI--------------------RTEYN 467

Query: 539  CLLKAWLTEKEEALNKVQTSNFKDQKELSVS-VRRLAILKEDMEMKRQTLDQLSEIGQDV 597
              LKA +      + +V   + + + EL  S +R L  L   +E  +  +D  +E G D+
Sbjct: 468  LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG-AEWGVDL 526

Query: 598  GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
              +     + + ++   EE   +    ++R      Q++ A      ++   +D L  + 
Sbjct: 527  PSVEAQLGSHRGLHQSIEEFRAK----IERARSDEGQLSPA------TRGAYRDCLGRLD 576

Query: 658  VREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKE 717
            ++   +   SK  L              +E+   F A + + L W+       +  E+  
Sbjct: 577  LQYAKLLNSSKARLR------------SLESLHSFVAAATKELMWL----NEKEEEEVGF 620

Query: 718  YMKMQDTSEMKKK--LKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEK 775
                ++T+   KK    AL +E   +  +  EL   G  L+ +      PT E      +
Sbjct: 621  DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE-DHPARPTVESFQAALQ 679

Query: 776  VSSEWK-----NVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS--E 828
                W       +  HL++     Q   D+     QL +L++ ++ K    +  +++  E
Sbjct: 680  TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLE 739

Query: 829  SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLG--RY 886
               Q     K+       +L GL      A+ + + +  +P  P    RG    L    Y
Sbjct: 740  DLLQDAQDEKEQLNEYKGHLSGL------AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY 793

Query: 887  QAVQEAVEDRQQHLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVE 944
            + V+  V       E +L G  QP H           VL+ S ++A V     +    V 
Sbjct: 794  KQVEVTVHKGD---ECQLVGPAQPSH---------WKVLSSSGSEAAVP----SVCFLVP 837

Query: 945  KALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV 1004
               QE +     LE Q  AL  L  +       +H D++ L           W  L+   
Sbjct: 838  PPNQEAQEAVTRLEAQHQALVTLWHQ-------LHVDMKSLL---------AWQSLR--- 878

Query: 1005 SKDLHLLEEIAL-TLRAF--EADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQRQLD 1057
             +D+ L+   +L T R    E     +       + FL   Q A G    D    +R+  
Sbjct: 879  -RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG 937

Query: 1058 QCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQK 1117
             CS   +  + +  SL+   + E+  +            + L D + QLE         +
Sbjct: 938  SCS---HHYQQLLQSLEQGAQEESRCQR---------CISELKDIRLQLEACETR-TVHR 984

Query: 1118 SRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQ 1177
             RL   +E A    + +AE Q+   QAE E L      K    L +  E           
Sbjct: 985  LRLPLDKEPARECAQRIAEQQK--AQAEVEGLG-----KGVARLSAEAE----------- 1026

Query: 1178 KEVRVKILKDNIKLLAAKVPS-GGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWI 1236
                        K+LA   PS     L SEL + L           GK   +  + + ++
Sbjct: 1027 ------------KVLALPEPSPAAPTLRSELELTL-----------GKLEQVRSLSAIYL 1063

Query: 1237 ELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQT 1296
            E L  + L        EE +++ E   ++  AV   L  LE+        R Q  E  Q 
Sbjct: 1064 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ-AEAQQP 1122

Query: 1297 LIDGGILDDI-----ISEKL-EAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQ 1350
              D  + D++     + E+L +    R  ++    E     LE+   VL +TD    V Q
Sbjct: 1123 TFD-ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD----VRQ 1177

Query: 1351 ESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELT-LEELRRNMRSQPLTSPESR 1409
              L +L +QL  Y           Q+A++ Q +I A  L   + +R  +R +     E  
Sbjct: 1178 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-- 1235

Query: 1410 TARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPD 1469
              R G +++  QR  +      Q      ++E +++  K  L+ V +      V+     
Sbjct: 1236 IERHGEKVEECQRFAK------QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1289

Query: 1470 VIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLG 1529
            VIQ ++D      +  +     ++ + +T R + ++++       ++Q    +    ++ 
Sbjct: 1290 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-----AEQQRAEERERLAEVE 1344

Query: 1530 AQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKN 1589
            A + + +Q  E  +Q   + ++EA  L + +   + E+V++  +      +D +    ++
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA-----VDAQ-QQKRS 1395

Query: 1590 VLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMN 1649
            + ++L++ +       ++ A      E S   +EE + V+                 L  
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL--------------QLEA 1441

Query: 1650 HQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRD 1709
             + Q    +G +  +     +AEA     +K+   ++ E ++R V +      Q E V  
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEA-----QKRQAQEEAERLRRQVQDESQRKRQAE-VEL 1495

Query: 1710 QALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETG 1769
             + +   A  +  ++     L EL    E+  + ++ A++  A++          + E  
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555

Query: 1770 VPFSDLEKLENDIENMLKFVEKHL---ESSDEDEKMDEESAQIEEVLQRGEEMLHQ-PME 1825
            +        E   +      E+H+   +  +E E+  ++ A+ E   +  E  L +  ++
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615

Query: 1826 DNKKEKIRLQ---------LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEI 1876
             N+  ++RLQ         L        K +A    +R+       +R   L    L + 
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675

Query: 1877 NKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEK------ 1930
             +  L     +  L   +    +  +    E   + ++++L +L  + A   +K      
Sbjct: 1676 RQ--LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733

Query: 1931 -------QPDVILEASGPEAIQIRDT----LTQLNAKWDRINRMYSDRKGCFDRAMEEWR 1979
                   + +V+L +      + R T      +L A+  R   +  +       A E  R
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793

Query: 1980 QFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTG 2039
            Q      D  +   EAE +L +  A  G    E  R+ + E E+ +   +     L R  
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIG----EATRL-KTEAEIALKEKEAENERLRRLA 1848

Query: 2040 DGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICW 2099
            +    +  + +    + K A + +R   +         R KG  +  ++ R Q++E I  
Sbjct: 1849 EDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907

Query: 2100 LTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDK 2159
            L KA          EL   L  +R   +      + L+   + ELE    + L+  E  +
Sbjct: 1908 L-KASFEKAAAGKAELELELGRIRSNAE------DTLRSKEQAELEAARQRQLAAEEERR 1960

Query: 2160 ISESLRTVNMTW---NKICREVPTTLKECIQEPSSVSQTR----IAAHPNVQKVVLVSSA 2212
              E+   V  +     +  R+    L+E  +  + V + R     A   + +++ L   A
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020

Query: 2213 SDIPVQSHRTSEISIPADLDKTITE-LADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKI 2271
            +   +Q+   +        ++ + + L     ++DQ+        G+ E   +     + 
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR-------GEAEAARRAAEEAEE 2073

Query: 2272 TKADLE----QRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVE-- 2325
             +   E    Q   Q++    L Q+ + +A +     A  EKL +   Q    +   E  
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133

Query: 2326 -LRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQEL 2384
             LRQ+Q  D      + + H++  E+ +R+   +  + Q+     L  + +D+Q  L   
Sbjct: 2134 ALRQKQAAD-----AEMEKHKKFAEQTLRQ---KAQVEQELTTLRLQLEETDHQKNL--- 2182

Query: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
                      D  LQ+L  E  ++  R   +  E L +  + +++ ++  +  +EAE R 
Sbjct: 2183 ---------LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAENRA 2231

Query: 2445 VQASRRDLENFLKWIQ-EAETTVNVLVDASHRENALQDSILARELKQQ---MQDIQAEID 2500
            +    RD +N  +++Q EAE    V  +A+    A Q++   R+L ++    Q   AE  
Sbjct: 2232 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-- 2287

Query: 2501 AHNDIFKSIDGNRQKMVKALGNSEEATMLQHR-----------LDDMNQRWNDLKAKSAS 2549
                  K +    Q + +A     EA +LQ +            +D  Q    L  ++  
Sbjct: 2288 ------KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341

Query: 2550 IRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKK-QMPIGGDVPALQLQYDHC--KALR 2606
             +  LE  AE+  +L MS E   + L ++  E+ + Q     D    + Q +    K  R
Sbjct: 2342 FQRTLE--AERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2397

Query: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
             EL  +E   L    + +   +D   E   E    L+ + E   +E      K+   Q+ 
Sbjct: 2398 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2457

Query: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQ 2697
            + ++  +   A+  ++  + D  L++ R ++
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 258/1460 (17%), Positives = 555/1460 (38%), Gaps = 213/1460 (14%)

Query: 259  TIDAIREVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDS 313
            T+  + E E L  + + E  E    +++   +     E H   +A+      E+   +  
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1377

Query: 314  YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF-ATHEAFMMELTAHQSSVGSVLQA 372
              +  EE      +A D  Q++  I +++++++    A  +A   +  A + S   + + 
Sbjct: 1378 EVVRREE------AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431

Query: 373  GNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSA 432
               +  Q   ++ +    + ++  L AR E    +    Q     +  ++Q +  ++  A
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLE--------EHKSLQSDLE-AEQVKVNSLTHM 483
             + L      K E     +  ++LQ L E        E +  Q+++E A QV+V   T  
Sbjct: 1492 EVELASR--VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549

Query: 484  VVIVDENSGESA-----TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQ 538
                 E   + A     TA LE  LQ   E   AV +  EE   R Q+     +   E +
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAE 1606

Query: 539  CLLKAWLTEKEEALN-KVQTSNFKDQKELSVS-----------------------VRRLA 574
              L+ W  +  EAL  ++Q      QK L+ +                       VR+  
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666

Query: 575  ILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQ 634
            + ++++E +RQ  +  ++      Q L   +   ++ +++E+  Q+   L + L     +
Sbjct: 1667 LAEQELEKQRQLAEGTAQ------QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720

Query: 635  VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDA 694
               A  K    Q  + +L +     E  +  K++ E       +K +  ++ EA +    
Sbjct: 1721 AAAATQK---RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR---- 1773

Query: 695  ISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQI 754
               EL     + +   +  + +  +  +D +  + + + +  E+   I  A  L    +I
Sbjct: 1774 -FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832

Query: 755  LVEQMGKEGLPTEEIKNVLEKVSSEWKNV----SQHLEDLERKI-QLQEDINAYFKQLDE 809
             +++   E    E ++ + E  + + + +    +QH  D+E ++ QL++  ++      E
Sbjct: 1833 ALKEKEAEN---ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------E 1883

Query: 810  LEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQP 869
            LE+     E+ ++     E   + + +LK S ++       L  ++   R++        
Sbjct: 1884 LERQKGLVEDTLRQRRQVE---EEILALKASFEKAAAGKAELELELGRIRSNAE------ 1934

Query: 870  SAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929
                      D+   + QA  EA   RQ   E E + +      E  + ++  L   E  
Sbjct: 1935 ----------DTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEA 1978

Query: 930  AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989
            A+     L ++ +++  ++E + L E  E +     +LA+E  A +K +  +     K  
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE--AAQKRLQAEE----KAH 2032

Query: 990  FDDVQGKWNKLKVLVSKDLHLLEEI-----ALTLRAFEADSTVIEKWMDGVKDFLMKQQA 1044
               VQ K  +L+  + ++  +L+++     A    A EA+   ++   +  +     ++A
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092

Query: 1045 AQ----GDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLG 1100
             +     ++    R   Q +A     E  + + +  +  +  LR    A  +     +  
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152

Query: 1101 DYQT-QLEKLSKEIATQKSRLSESQ-------EKAANLKKDLAEMQEWMTQAEEEYLERD 1152
            +    Q  ++ +E+ T + +L E+        E+   LK +  E     +Q EEE     
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 1153 FEYKSPEELESAVEEMKRA----KEDVLQKEVRVKILK-DNIKLLAAKVPSGGQELTSEL 1207
             + +   +L++ +E   RA     +D  Q+ ++ +  K   +   AA++    QE     
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272

Query: 1208 NVVLENYQ----LLCNRIRGKCHTLEEVWSCWIE---LLHYLDLETTWLNTLEE-RMKST 1259
             +  E+      L    ++ K   ++E      E   L    +L       L+E + +  
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332

Query: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE 1319
            + L E+T      LE+     +   +   +   L   + +         E  + F  + E
Sbjct: 2333 QQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389

Query: 1320 DL------SHLAESKQISLEKQLQVLRE-TDQMLQVLQESLGELDKQLTTYLTDRIDAFQ 1372
            ++      + LA  ++++L + L++ R+ +D   + L+E++ EL++              
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER-------------- 2435

Query: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432
               E +K+Q E    +L  EE++   + Q L   ++      S+ D L ++ R +     
Sbjct: 2436 ---EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2488

Query: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV 1492
              Q+ A  EQ   D     +  KA+     +++      Q    +  +L  ++ E +   
Sbjct: 2489 --QEKAKLEQLFQD-----EVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEARRR- 2536

Query: 1493 ETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKE 1552
                       Q +  +  +   E+L  L+         + E  Q L    QL  +  + 
Sbjct: 2537 -----------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585

Query: 1553 AASLSEWLSATETELVQ-----KSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE- 1606
            A + SE ++A++    +     +   +G   + + E S+      D  +RK     + E 
Sbjct: 2586 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF------DGLRRKVSAQRLQEA 2639

Query: 1607 ---SSAALQNLIEGSEPILE 1623
               S+  LQ L +G   + E
Sbjct: 2640 GILSAEELQRLAQGHTTVDE 2659



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 157/946 (16%), Positives = 366/946 (38%), Gaps = 144/946 (15%)

Query: 1800 EKMDEESAQIEEVLQRGEEMLHQPMEDNK--KEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857
            E  D   A +++  +R E++   P+ D++  +E++R +  LL       + +   QR   
Sbjct: 1192 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1251

Query: 1858 QLASGIRS-SLLPTDYLVEINKIL--------------LCMDDVELSLNVPELNTAIYED 1902
            Q  + I+   L    Y  ++  +               +  + V+L  +  EL T   + 
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311

Query: 1903 FSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINR 1962
              F  ++L+ ++++ ++L EQ     E++    +EA+  +  Q+ +   Q  A+ +R   
Sbjct: 1312 IKFISETLRRMEEE-ERLAEQQRA-EERERLAEVEAALEKQRQLAEAHAQAKAQAER--- 1366

Query: 1963 MYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQ-EL 2021
               + K    R  EE              +   EE  VD      S+  E  ++ Q  E 
Sbjct: 1367 ---EAKELQQRMQEE--------------VVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1409

Query: 2022 EVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081
            E+   + Q   A  +R       ++ +      + +  G      A+ A  ++ + + + 
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469

Query: 2082 ESKQVMKYRHQLDEIICWLTKAEHAMQKR--STTELGENLQELRDLTQEMEVHAEKL-KW 2138
              ++  + R Q+ +      +AE  +  R  +  E     Q      +E+ + AE+  + 
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529

Query: 2139 LNRTELEMLSDKSLSLPERDKISES-LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
            L + E+E      ++L    + +E+ L++   ++ +   ++  +L+E   E  +V+Q R 
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE---EHVAVAQLRE 1586

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257
             A    Q+            ++ R  E        +   EL  W +  ++ L+  +    
Sbjct: 1587 EAERRAQQ----------QAEAERARE--------EAERELERWQLKANEALRLRL---- 1624

Query: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQW 2317
               +  +   +  + +A+ E++  + +      +  K +  +   R    ++LE+ +   
Sbjct: 1625 ---QAEEVAQQKSLAQAEAEKQKEEAER--EARRRGKAEEQAVRQRELAEQELEKQRQLA 1679

Query: 2318 DGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRD---PLTKQI 2374
            +GT       +Q+L  +  ++ Q +  R+  EE + + +       Q R++    L K  
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1739

Query: 2375 SDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADR 2434
            ++ ++LL                     +    +++R+  E +                 
Sbjct: 1740 AEMEVLLAS-------------------KARAEEESRSTSEKS----------------- 1763

Query: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
            +  LEAE    +    +        +EA+    +  + + R+ A  + +LA +L    + 
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823

Query: 2495 IQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM-NQRWNDLKAKSASIRAH 2553
             + + +A   + K  +   +++ +    +E+    + RL++   Q   D++ + A +R  
Sbjct: 1824 TRLKTEAEIAL-KEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879

Query: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRREL---- 2609
             ++  E+   L+             ++ L+++  +  ++ AL+  ++   A + EL    
Sbjct: 1880 SDSELERQKGLV-------------EDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1926

Query: 2610 ---KEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS----KTELTPEERAQKIAKAMR 2662
               +      L + +QA +  A Q   A EE RR  ++    +  L  EE A +  KA  
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986

Query: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMK 2708
            ++   +K K E    +    +++  + L+  +  + A   L A+ K
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQAEEK 2030



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 146/749 (19%), Positives = 296/749 (39%), Gaps = 97/749 (12%)

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAE---VKDRQPRLKGESKQ 2085
            +   A L R      QK  +     L+ +LA +    + ++A     ++       +SKQ
Sbjct: 1711 EEELARLQREAAAATQKRQE-----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765

Query: 2086 VM-----KYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLN 2140
             +     ++R   +E       AE A ++R   E        R   +   V AEKL  + 
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE----DAARQRAEAERVLAEKLAAIG 1821

Query: 2141 RTELEMLSDKSLSLPERDKISESLRTV---NMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
                 + ++  ++L E++  +E LR +        +   E     K  I+E   ++Q R 
Sbjct: 1822 EAT-RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE--RLAQLRK 1878

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSE--ISIPADLDKTITELADWLVLIDQMLKSNIVT 2255
            A+   +++        D   Q  +  E  +++ A  +K     A+  + + ++  +   T
Sbjct: 1879 ASDSELERQK--GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936

Query: 2256 VGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKN 2315
            +   E+     +R +   A+ E+R  + +    + ++L  +  ++  R A  E++ER+K 
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKA 1994

Query: 2316 QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQIS 2375
            + +  +   E  +Q+    +  + +    R + EE     +A  + +QQ  ++ L + + 
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAHAFAVQQKEQE-LQQTLQ 2048

Query: 2376 DNQILLQEL-GPGDGIVMAFDNVLQKLLE-EYGSDDTRNVKETTEYLKTSWINLKQSIAD 2433
              Q +L +L G  +    A +   +  ++ E  +  +R   E  E LK S     Q+ A 
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108

Query: 2434 RQNALE------------------AEWRTVQASRRDLENFLKW----------IQEAETT 2465
             Q A E                  A  R  QA+  ++E   K+          +++  TT
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168

Query: 2466 VNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSE- 2524
            + + ++ +  +  L D  L R   +  +  +       ++F S+    +++ K     E 
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKLKARIEA 2227

Query: 2525 EATMLQHRLDDMNQRWNDLKAKS----ASIRAHLEASAEKWNRLLMSLEELI-------- 2572
            E   L  R  D  QR+   +A+     A   A L  +A++  RL    EE +        
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287

Query: 2573 KWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE-KEYSVLNAVDQARVFLADQP 2631
            K L  K + +++   +  +   LQ Q +  +   R L+E KE       ++ + F   + 
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF--QRT 2345

Query: 2632 IEAPEEPRRNLQSKTELTP---------EERAQKIAKAMRKQSSEVKEKWESLNAVTSNW 2682
            +EA  + +  + ++ E            + RA++ A+  RKQ+ E+ EK       T   
Sbjct: 2346 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--- 2402

Query: 2683 QKQVDKALEKLRDLQGAMDDLDAD-MKEA 2710
              Q    L +  ++Q    D DA+ ++EA
Sbjct: 2403 --QEKVTLVQTLEIQRQQSDHDAERLREA 2429



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 50/227 (22%), Positives = 88/227 (38%), Gaps = 9/227 (3%)

Query: 3195 EQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKS 3254
            E+   R+A+M R       D+       E+    + +    L  +  V+  Q+  +I + 
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR--TELATQEKVTLVQT-LEIQRQ 2417

Query: 3255 VEREERGELERIIADLEEEQRNLQVEYE--QLKDQHLRRGLPVGSPPES-IISPHHTSED 3311
                +   L   IA+LE E+  LQ E +  QLK + ++         E+  +     SE 
Sbjct: 2418 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2477

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASP 3371
              L+   + + Q K +LE   Q      +QL  +  R +Q +EQ E    +  +      
Sbjct: 2478 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ-ERQRLVASMEEARRR 2536

Query: 3372 QHSALSYSLDPDASGPQFHQ--AAGEDLLAPPHDTSTDLTEVMEQIH 3416
            QH A            Q  Q     E+LLA  +    +  +++E+ H
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  280 bits (716), Expect = 2e-74
 Identities = 583/2788 (20%), Positives = 1082/2788 (38%), Gaps = 414/2788 (14%)

Query: 18   FSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTS 77
            + ++ +   DE + VQKKTFTKW+N    K+ +  I+D++ DL+DG  L+ LLE L+G S
Sbjct: 15   YEEVREKYKDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISLLEVLSGDS 73

Query: 78   LPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVK 137
            LP+E+G  R H L NV   L  L    V+LVNI   DI DGN KLTLGL+W+IILH+Q+ 
Sbjct: 74   LPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 133

Query: 138  DVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLF 197
            D+     S+   T  EK+LL W ++    Y  +   NFT+SW DG  FNA++HRHKP L 
Sbjct: 134  DIQVSGQSE-DMTAKEKLLL-WSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 191

Query: 198  SWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQ 257
              +KV + + +E L+ AFS A+  LG+ +LLDPEDV V  PD+KSII Y++SL++ +P+ 
Sbjct: 192  DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR- 250

Query: 258  VTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIA 317
                                                  P  +      E+ +    Y+  
Sbjct: 251  -------------------------------------VPDVQDGVRANELQLRWQEYREL 273

Query: 318  LEEVLTWLLSAEDTFQEQDDIS--DDVEEVKDQFATHEAFMMELTAHQS----------S 365
            +  +L W+      F+E+   S  +++E +  QF   +   MEL A ++          S
Sbjct: 274  VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE--MELPAKEADKNRSKGIYQS 331

Query: 366  VGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQ 423
            +   +QAG   +  G    + E E           W  L V  ++R+ +L      +E  
Sbjct: 332  LEGAVQAGQLKVPPGYHPLDVEKE-----------WGKLHVAILEREKQLRSEFERLECL 380

Query: 424  KKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQ--KLLEEHKSLQSDLEAEQVKVNSLT 481
            ++ + +L     L EE++ + +   L  DV+ L   K+ +    ++ DL+     +  L 
Sbjct: 381  QRIVTKLQMEAGLCEEQLNQADAL-LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 439

Query: 482  HMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLL 541
            + V  + +        +   ++ +L ER  A+                      E    L
Sbjct: 440  NDVQTLKDGRHPQGEQMYR-RVYRLHERLVAI--------------------RTEYNLRL 478

Query: 542  KAWLTEKEEALNKVQTSNFKDQKELSVS-VRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600
            KA +      + +V   + + + EL  S +R L  L   +E  +  +D  +E G D+  +
Sbjct: 479  KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG-AEWGVDLPSV 537

Query: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660
                 + + ++   EE   +    ++R      Q++ A      ++   +D L  + ++ 
Sbjct: 538  EAQLGSHRGLHQSIEEFRAK----IERARSDEGQLSPA------TRGAYRDCLGRLDLQY 587

Query: 661  QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK 720
              +   SK  L              +E+   F A + + L W+       +  E+     
Sbjct: 588  AKLLNSSKARLR------------SLESLHSFVAAATKELMWL----NEKEEEEVGFDWS 631

Query: 721  MQDTSEMKKK--LKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSS 778
             ++T+   KK    AL +E   +  +  EL   G  L+ +      PT E      +   
Sbjct: 632  DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE-DHPARPTVESFQAALQTQW 690

Query: 779  EWK-----NVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS--ESSR 831
             W       +  HL++     Q   D+     QL +L++ ++ K    +  +++  E   
Sbjct: 691  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 750

Query: 832  QSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLG--RYQAV 889
            Q     K+       +L GL      A+ + + +  +P  P    RG    L    Y+ V
Sbjct: 751  QDAQDEKEQLNEYKGHLSGL------AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV 804

Query: 890  QEAVEDRQQHLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKAL 947
            +  V       E +L G  QP H           VL+ S ++A V     +    V    
Sbjct: 805  EVTVHKGD---ECQLVGPAQPSH---------WKVLSSSGSEAAVP----SVCFLVPPPN 848

Query: 948  QEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKD 1007
            QE +     LE Q  AL  L  +       +H D++ L           W  L+    +D
Sbjct: 849  QEAQEAVTRLEAQHQALVTLWHQ-------LHVDMKSLL---------AWQSLR----RD 888

Query: 1008 LHLLEEIAL-TLRAF--EADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQRQLDQCS 1060
            + L+   +L T R    E     +       + FL   Q A G    D    +R+   CS
Sbjct: 889  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 948

Query: 1061 AFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
               +  + +  SL+   + E+  +            + L D + QLE         + RL
Sbjct: 949  ---HHYQQLLQSLEQGAQEESRCQR---------CISELKDIRLQLEACETR-TVHRLRL 995

Query: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV 1180
               +E A    + +AE Q+   QAE E L      K    L +  E              
Sbjct: 996  PLDKEPARECAQRIAEQQK--AQAEVEGLG-----KGVARLSAEAE-------------- 1034

Query: 1181 RVKILKDNIKLLAAKVPS-GGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELL 1239
                     K+LA   PS     L SEL + L           GK   +  + + ++E L
Sbjct: 1035 ---------KVLALPEPSPAAPTLRSELELTL-----------GKLEQVRSLSAIYLEKL 1074

Query: 1240 HYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLID 1299
              + L        EE +++ E   ++  AV   L  LE+        R Q  E  Q   D
Sbjct: 1075 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ-AEAQQPTFD 1133

Query: 1300 GGILDDI-----ISEKL-EAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
              + D++     + E+L +    R  ++    E     LE+   VL +TD    V Q  L
Sbjct: 1134 -ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD----VRQREL 1188

Query: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELT-LEELRRNMRSQPLTSPESRTAR 1412
             +L +QL  Y           Q+A++ Q +I A  L   + +R  +R +     E    R
Sbjct: 1189 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE--IER 1246

Query: 1413 GGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQ 1472
             G +++  QR  +      Q      ++E +++  K  L+ V +      V+     VIQ
Sbjct: 1247 HGEKVEECQRFAK------QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1300

Query: 1473 THLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV 1532
             ++D      +  +     ++ + +T R + ++++       ++Q    +    ++ A +
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-----AEQQRAEERERLAEVEAAL 1355

Query: 1533 TEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLK 1592
             + +Q  E  +Q   + ++EA  L + +   + E+V++  +      +D +    +++ +
Sbjct: 1356 EKQRQLAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA-----VDAQ-QQKRSIQE 1406

Query: 1593 DLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQN 1652
            +L++ +       ++ A      E S   +EE + V+                 L   + 
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL--------------QLEATER 1452

Query: 1653 QLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQAL 1712
            Q    +G +  +     +AEA     +K+   ++ E ++R V +      Q E V   + 
Sbjct: 1453 QRGGAEGELQALRARAEEAEA-----QKRQAQEEAERLRRQVQDESQRKRQAE-VELASR 1506

Query: 1713 ILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPF 1772
            +   A  +  ++     L EL    E+  + ++ A++  A++          + E  +  
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566

Query: 1773 SDLEKLENDIENMLKFVEKHL---ESSDEDEKMDEESAQIEEVLQRGEEMLHQ-PMEDNK 1828
                  E   +      E+H+   +  +E E+  ++ A+ E   +  E  L +  ++ N+
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626

Query: 1829 KEKIRLQ---------LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKI 1879
              ++RLQ         L        K +A    +R+       +R   L    L +  + 
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1685

Query: 1880 LLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEK--------- 1930
             L     +  L   +    +  +    E   + ++++L +L  + A   +K         
Sbjct: 1686 -LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 1931 ----QPDVILEASGPEAIQIRDT----LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
                + +V+L +      + R T      +L A+  R   +  +       A E  RQ  
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804

Query: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGI 2042
                D  +   EAE +L +  A  G    E  R+ + E E+ +   +     L R  +  
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIG----EATRL-KTEAEIALKEKEAENERLRRLAEDE 1859

Query: 2043 VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTK 2102
              +  + +    + K A + +R   +         R KG  +  ++ R Q++E I  L K
Sbjct: 1860 AFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL-K 1917

Query: 2103 AEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISE 2162
            A          EL   L  +R   +      + L+   + ELE    + L+  E  +  E
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAE------DTLRSKEQAELEAARQRQLAAEEERRRRE 1971

Query: 2163 SLRTVNMTW---NKICREVPTTLKECIQEPSSVSQTR----IAAHPNVQKVVLVSSASDI 2215
            +   V  +     +  R+    L+E  +  + V + R     A   + +++ L   A+  
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2031

Query: 2216 PVQSHRTSEISIPADLDKTITE-LADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKA 2274
             +Q+   +        ++ + + L     ++DQ+        G+ E   +     +  + 
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR-------GEAEAARRAAEEAEEARV 2084

Query: 2275 DLE----QRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVE---LR 2327
              E    Q   Q++    L Q+ + +A +     A  EKL +   Q    +   E   LR
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144

Query: 2328 QQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPG 2387
            Q+Q  D      + + H++  E+ +R+   +  + Q+     L  + +D+Q  L      
Sbjct: 2145 QKQAAD-----AEMEKHKKFAEQTLRQ---KAQVEQELTTLRLQLEETDHQKNL------ 2190

Query: 2388 DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQA 2447
                   D  LQ+L  E  ++  R   +  E L +  + +++ ++  +  +EAE R +  
Sbjct: 2191 ------LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAENRAL-- 2240

Query: 2448 SRRDLENFLKWIQ-EAETTVNVLVDASHRENALQDSILARELKQQ---MQDIQAEIDAHN 2503
              RD +N  +++Q EAE    V  +A+    A Q++   R+L ++    Q   AE     
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE----- 2295

Query: 2504 DIFKSIDGNRQKMVKALGNSEEATMLQHR-----------LDDMNQRWNDLKAKSASIRA 2552
               K +    Q + +A     EA +LQ +            +D  Q    L  ++   + 
Sbjct: 2296 ---KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2352

Query: 2553 HLEASAEKWNRLLMSLEELIKWLNMKDEELKK-QMPIGGDVPALQLQYDHC--KALRREL 2609
             LE  AE+  +L MS E   + L ++  E+ + Q     D    + Q +    K  R EL
Sbjct: 2353 TLE--AERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2408

Query: 2610 KEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVK 2669
              +E   L    + +   +D   E   E    L+ + E   +E      K+   Q+ + +
Sbjct: 2409 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2468

Query: 2670 EKWESLNAVTSNWQKQVDKALEKLRDLQ 2697
            +  +   A+  ++  + D  L++ R ++
Sbjct: 2469 QLLQETQALQQSFLSEKDSLLQRERFIE 2496



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 258/1460 (17%), Positives = 555/1460 (38%), Gaps = 213/1460 (14%)

Query: 259  TIDAIREVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDS 313
            T+  + E E L  + + E  E    +++   +     E H   +A+      E+   +  
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1385

Query: 314  YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF-ATHEAFMMELTAHQSSVGSVLQA 372
              +  EE      +A D  Q++  I +++++++    A  +A   +  A + S   + + 
Sbjct: 1386 EVVRREE------AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439

Query: 373  GNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSA 432
               +  Q   ++ +    + ++  L AR E    +    Q     +  ++Q +  ++  A
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLE--------EHKSLQSDLE-AEQVKVNSLTHM 483
             + L      K E     +  ++LQ L E        E +  Q+++E A QV+V   T  
Sbjct: 1500 EVELASR--VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557

Query: 484  VVIVDENSGESA-----TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQ 538
                 E   + A     TA LE  LQ   E   AV +  EE   R Q+     +   E +
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAE 1614

Query: 539  CLLKAWLTEKEEALN-KVQTSNFKDQKELSVS-----------------------VRRLA 574
              L+ W  +  EAL  ++Q      QK L+ +                       VR+  
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1674

Query: 575  ILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQ 634
            + ++++E +RQ  +  ++      Q L   +   ++ +++E+  Q+   L + L     +
Sbjct: 1675 LAEQELEKQRQLAEGTAQ------QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728

Query: 635  VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDA 694
               A  K    Q  + +L +     E  +  K++ E       +K +  ++ EA +    
Sbjct: 1729 AAAATQK---RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR---- 1781

Query: 695  ISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQI 754
               EL     + +   +  + +  +  +D +  + + + +  E+   I  A  L    +I
Sbjct: 1782 -FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1840

Query: 755  LVEQMGKEGLPTEEIKNVLEKVSSEWKNV----SQHLEDLERKI-QLQEDINAYFKQLDE 809
             +++   E    E ++ + E  + + + +    +QH  D+E ++ QL++  ++      E
Sbjct: 1841 ALKEKEAEN---ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------E 1891

Query: 810  LEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQP 869
            LE+     E+ ++     E   + + +LK S ++       L  ++   R++        
Sbjct: 1892 LERQKGLVEDTLRQRRQVE---EEILALKASFEKAAAGKAELELELGRIRSNAE------ 1942

Query: 870  SAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929
                      D+   + QA  EA   RQ   E E + +      E  + ++  L   E  
Sbjct: 1943 ----------DTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEA 1986

Query: 930  AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989
            A+     L ++ +++  ++E + L E  E +     +LA+E  A +K +  +     K  
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE--AAQKRLQAEE----KAH 2040

Query: 990  FDDVQGKWNKLKVLVSKDLHLLEEI-----ALTLRAFEADSTVIEKWMDGVKDFLMKQQA 1044
               VQ K  +L+  + ++  +L+++     A    A EA+   ++   +  +     ++A
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100

Query: 1045 AQ----GDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLG 1100
             +     ++    R   Q +A     E  + + +  +  +  LR    A  +     +  
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160

Query: 1101 DYQT-QLEKLSKEIATQKSRLSESQ-------EKAANLKKDLAEMQEWMTQAEEEYLERD 1152
            +    Q  ++ +E+ T + +L E+        E+   LK +  E     +Q EEE     
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 1153 FEYKSPEELESAVEEMKRA----KEDVLQKEVRVKILK-DNIKLLAAKVPSGGQELTSEL 1207
             + +   +L++ +E   RA     +D  Q+ ++ +  K   +   AA++    QE     
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280

Query: 1208 NVVLENYQ----LLCNRIRGKCHTLEEVWSCWIE---LLHYLDLETTWLNTLEE-RMKST 1259
             +  E+      L    ++ K   ++E      E   L    +L       L+E + +  
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340

Query: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE 1319
            + L E+T      LE+     +   +   +   L   + +         E  + F  + E
Sbjct: 2341 QQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397

Query: 1320 DL------SHLAESKQISLEKQLQVLRE-TDQMLQVLQESLGELDKQLTTYLTDRIDAFQ 1372
            ++      + LA  ++++L + L++ R+ +D   + L+E++ EL++              
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER-------------- 2443

Query: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432
               E +K+Q E    +L  EE++   + Q L   ++      S+ D L ++ R +     
Sbjct: 2444 ---EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2496

Query: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV 1492
              Q+ A  EQ   D     +  KA+     +++      Q    +  +L  ++ E +   
Sbjct: 2497 --QEKAKLEQLFQD-----EVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEARRR- 2544

Query: 1493 ETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKE 1552
                       Q +  +  +   E+L  L+         + E  Q L    QL  +  + 
Sbjct: 2545 -----------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593

Query: 1553 AASLSEWLSATETELVQ-----KSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE- 1606
            A + SE ++A++    +     +   +G   + + E S+      D  +RK     + E 
Sbjct: 2594 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF------DGLRRKVSAQRLQEA 2647

Query: 1607 ---SSAALQNLIEGSEPILE 1623
               S+  LQ L +G   + E
Sbjct: 2648 GILSAEELQRLAQGHTTVDE 2667



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 157/946 (16%), Positives = 366/946 (38%), Gaps = 144/946 (15%)

Query: 1800 EKMDEESAQIEEVLQRGEEMLHQPMEDNK--KEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857
            E  D   A +++  +R E++   P+ D++  +E++R +  LL       + +   QR   
Sbjct: 1200 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1259

Query: 1858 QLASGIRS-SLLPTDYLVEINKIL--------------LCMDDVELSLNVPELNTAIYED 1902
            Q  + I+   L    Y  ++  +               +  + V+L  +  EL T   + 
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319

Query: 1903 FSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINR 1962
              F  ++L+ ++++ ++L EQ     E++    +EA+  +  Q+ +   Q  A+ +R   
Sbjct: 1320 IKFISETLRRMEEE-ERLAEQQRA-EERERLAEVEAALEKQRQLAEAHAQAKAQAER--- 1374

Query: 1963 MYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQ-EL 2021
               + K    R  EE              +   EE  VD      S+  E  ++ Q  E 
Sbjct: 1375 ---EAKELQQRMQEE--------------VVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1417

Query: 2022 EVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081
            E+   + Q   A  +R       ++ +      + +  G      A+ A  ++ + + + 
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477

Query: 2082 ESKQVMKYRHQLDEIICWLTKAEHAMQKR--STTELGENLQELRDLTQEMEVHAEKL-KW 2138
              ++  + R Q+ +      +AE  +  R  +  E     Q      +E+ + AE+  + 
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537

Query: 2139 LNRTELEMLSDKSLSLPERDKISES-LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
            L + E+E      ++L    + +E+ L++   ++ +   ++  +L+E   E  +V+Q R 
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE---EHVAVAQLRE 1594

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257
             A    Q+            ++ R  E        +   EL  W +  ++ L+  +    
Sbjct: 1595 EAERRAQQ----------QAEAERARE--------EAERELERWQLKANEALRLRL---- 1632

Query: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQW 2317
               +  +   +  + +A+ E++  + +      +  K +  +   R    ++LE+ +   
Sbjct: 1633 ---QAEEVAQQKSLAQAEAEKQKEEAER--EARRRGKAEEQAVRQRELAEQELEKQRQLA 1687

Query: 2318 DGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRD---PLTKQI 2374
            +GT       +Q+L  +  ++ Q +  R+  EE + + +       Q R++    L K  
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1747

Query: 2375 SDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADR 2434
            ++ ++LL                     +    +++R+  E +                 
Sbjct: 1748 AEMEVLLAS-------------------KARAEEESRSTSEKS----------------- 1771

Query: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
            +  LEAE    +    +        +EA+    +  + + R+ A  + +LA +L    + 
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831

Query: 2495 IQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM-NQRWNDLKAKSASIRAH 2553
             + + +A   + K  +   +++ +    +E+    + RL++   Q   D++ + A +R  
Sbjct: 1832 TRLKTEAEIAL-KEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887

Query: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRREL---- 2609
             ++  E+   L+             ++ L+++  +  ++ AL+  ++   A + EL    
Sbjct: 1888 SDSELERQKGLV-------------EDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1934

Query: 2610 ---KEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS----KTELTPEERAQKIAKAMR 2662
               +      L + +QA +  A Q   A EE RR  ++    +  L  EE A +  KA  
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMK 2708
            ++   +K K E    +    +++  + L+  +  + A   L A+ K
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQAEEK 2038



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 146/749 (19%), Positives = 296/749 (39%), Gaps = 97/749 (12%)

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAE---VKDRQPRLKGESKQ 2085
            +   A L R      QK  +     L+ +LA +    + ++A     ++       +SKQ
Sbjct: 1719 EEELARLQREAAAATQKRQE-----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773

Query: 2086 VM-----KYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLN 2140
             +     ++R   +E       AE A ++R   E        R   +   V AEKL  + 
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE----DAARQRAEAERVLAEKLAAIG 1829

Query: 2141 RTELEMLSDKSLSLPERDKISESLRTV---NMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
                 + ++  ++L E++  +E LR +        +   E     K  I+E   ++Q R 
Sbjct: 1830 EAT-RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE--RLAQLRK 1886

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSE--ISIPADLDKTITELADWLVLIDQMLKSNIVT 2255
            A+   +++        D   Q  +  E  +++ A  +K     A+  + + ++  +   T
Sbjct: 1887 ASDSELERQK--GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944

Query: 2256 VGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKN 2315
            +   E+     +R +   A+ E+R  + +    + ++L  +  ++  R A  E++ER+K 
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 2316 QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQIS 2375
            + +  +   E  +Q+    +  + +    R + EE     +A  + +QQ  ++ L + + 
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAHAFAVQQKEQE-LQQTLQ 2056

Query: 2376 DNQILLQEL-GPGDGIVMAFDNVLQKLLE-EYGSDDTRNVKETTEYLKTSWINLKQSIAD 2433
              Q +L +L G  +    A +   +  ++ E  +  +R   E  E LK S     Q+ A 
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116

Query: 2434 RQNALE------------------AEWRTVQASRRDLENFLKW----------IQEAETT 2465
             Q A E                  A  R  QA+  ++E   K+          +++  TT
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2176

Query: 2466 VNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSE- 2524
            + + ++ +  +  L D  L R   +  +  +       ++F S+    +++ K     E 
Sbjct: 2177 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKLKARIEA 2235

Query: 2525 EATMLQHRLDDMNQRWNDLKAKS----ASIRAHLEASAEKWNRLLMSLEELI-------- 2572
            E   L  R  D  QR+   +A+     A   A L  +A++  RL    EE +        
Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295

Query: 2573 KWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE-KEYSVLNAVDQARVFLADQP 2631
            K L  K + +++   +  +   LQ Q +  +   R L+E KE       ++ + F   + 
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF--QRT 2353

Query: 2632 IEAPEEPRRNLQSKTELTP---------EERAQKIAKAMRKQSSEVKEKWESLNAVTSNW 2682
            +EA  + +  + ++ E            + RA++ A+  RKQ+ E+ EK       T   
Sbjct: 2354 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--- 2410

Query: 2683 QKQVDKALEKLRDLQGAMDDLDAD-MKEA 2710
              Q    L +  ++Q    D DA+ ++EA
Sbjct: 2411 --QEKVTLVQTLEIQRQQSDHDAERLREA 2437



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 50/227 (22%), Positives = 88/227 (38%), Gaps = 9/227 (3%)

Query: 3195 EQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKS 3254
            E+   R+A+M R       D+       E+    + +    L  +  V+  Q+  +I + 
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR--TELATQEKVTLVQT-LEIQRQ 2425

Query: 3255 VEREERGELERIIADLEEEQRNLQVEYE--QLKDQHLRRGLPVGSPPES-IISPHHTSED 3311
                +   L   IA+LE E+  LQ E +  QLK + ++         E+  +     SE 
Sbjct: 2426 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2485

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASP 3371
              L+   + + Q K +LE   Q      +QL  +  R +Q +EQ E    +  +      
Sbjct: 2486 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ-ERQRLVASMEEARRR 2544

Query: 3372 QHSALSYSLDPDASGPQFHQ--AAGEDLLAPPHDTSTDLTEVMEQIH 3416
            QH A            Q  Q     E+LLA  +    +  +++E+ H
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  280 bits (715), Expect = 2e-74
 Identities = 583/2783 (20%), Positives = 1080/2783 (38%), Gaps = 414/2783 (14%)

Query: 23   KSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKER 82
            + + DE + VQKKTFTKW+N    K+ +  I+D++ DL+DG  L+ LLE L+G SLP+E+
Sbjct: 34   EGKKDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISLLEVLSGDSLPREK 92

Query: 83   GSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKD 142
            G  R H L NV   L  L    V+LVNI   DI DGN KLTLGL+W+IILH+Q+ D+   
Sbjct: 93   GRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVS 152

Query: 143  VMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKV 202
              S+   T  EK+LL W ++    Y  +   NFT+SW DG  FNA++HRHKP L   +KV
Sbjct: 153  GQSE-DMTAKEKLLL-WSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKV 210

Query: 203  VKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDA 262
             + + +E L+ AFS A+  LG+ +LLDPEDV V  PD+KSII Y++SL++ +P+      
Sbjct: 211  YRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR------ 264

Query: 263  IREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVL 322
                                             P  +      E+ +    Y+  +  +L
Sbjct: 265  --------------------------------VPDVQDGVRANELQLRWQEYRELVLLLL 292

Query: 323  TWLLSAEDTFQEQDDIS--DDVEEVKDQFATHEAFMMELTAHQS----------SVGSVL 370
             W+      F+E+   S  +++E +  QF   +   MEL A ++          S+   +
Sbjct: 293  QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE--MELPAKEADKNRSKGIYQSLEGAV 350

Query: 371  QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQLQ 428
            QAG   +  G    + E E           W  L V  ++R+ +L      +E  ++ + 
Sbjct: 351  QAGQLKVPPGYHPLDVEKE-----------WGKLHVAILEREKQLRSEFERLECLQRIVT 399

Query: 429  QLSAWLTLTEERIQKMETCPLDDDVKSLQ--KLLEEHKSLQSDLEAEQVKVNSLTHMVVI 486
            +L     L EE++ + +   L  DV+ L   K+ +    ++ DL+     +  L + V  
Sbjct: 400  KLQMEAGLCEEQLNQADAL-LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458

Query: 487  VDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLT 546
            + +        +   ++ +L ER  A+                      E    LKA + 
Sbjct: 459  LKDGRHPQGEQMYR-RVYRLHERLVAI--------------------RTEYNLRLKAGVA 497

Query: 547  EKEEALNKVQTSNFKDQKELSVS-VRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSK 605
                 + +V   + + + EL  S +R L  L   +E  +  +D  +E G D+  +     
Sbjct: 498  APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG-AEWGVDLPSVEAQLG 556

Query: 606  ASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITK 665
            + + ++   EE   +    ++R      Q++ A      ++   +D L  + ++   +  
Sbjct: 557  SHRGLHQSIEEFRAK----IERARSDEGQLSPA------TRGAYRDCLGRLDLQYAKLLN 606

Query: 666  KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS 725
             SK  L              +E+   F A + + L W+       +  E+      ++T+
Sbjct: 607  SSKARLR------------SLESLHSFVAAATKELMWL----NEKEEEEVGFDWSDRNTN 650

Query: 726  EMKKK--LKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWK-- 781
               KK    AL +E   +  +  EL   G  L+ +      PT E      +    W   
Sbjct: 651  MTAKKESYSALMRELELKEKKIKELQNAGDRLLRE-DHPARPTVESFQAALQTQWSWMLQ 709

Query: 782  ---NVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS--ESSRQSLPS 836
                +  HL++     Q   D+     QL +L++ ++ K    +  +++  E   Q    
Sbjct: 710  LCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQD 769

Query: 837  LKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLG--RYQAVQEAVE 894
             K+       +L GL      A+ + + +  +P  P    RG    L    Y+ V+  V 
Sbjct: 770  EKEQLNEYKGHLSGL------AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 823

Query: 895  DRQQHLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKT 952
                  E +L G  QP H           VL+ S ++A V     +    V    QE + 
Sbjct: 824  KGD---ECQLVGPAQPSH---------WKVLSSSGSEAAVP----SVCFLVPPPNQEAQE 867

Query: 953  LDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE 1012
                LE Q  AL  L  +       +H D++ L           W  L+    +D+ L+ 
Sbjct: 868  AVTRLEAQHQALVTLWHQ-------LHVDMKSLL---------AWQSLR----RDVQLIR 907

Query: 1013 EIAL-TLRAF--EADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQRQLDQCSAFVNE 1065
              +L T R    E     +       + FL   Q A G    D    +R+   CS   + 
Sbjct: 908  SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS---HH 964

Query: 1066 IETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQE 1125
             + +  SL+   + E+  +            + L D + QLE         + RL   +E
Sbjct: 965  YQQLLQSLEQGAQEESRCQR---------CISELKDIRLQLEACETR-TVHRLRLPLDKE 1014

Query: 1126 KAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKIL 1185
             A    + +AE Q+   QAE E L      K    L +  E                   
Sbjct: 1015 PARECAQRIAEQQK--AQAEVEGLG-----KGVARLSAEAE------------------- 1048

Query: 1186 KDNIKLLAAKVPS-GGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDL 1244
                K+LA   PS     L SEL + L           GK   +  + + ++E L  + L
Sbjct: 1049 ----KVLALPEPSPAAPTLRSELELTL-----------GKLEQVRSLSAIYLEKLKTISL 1093

Query: 1245 ETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILD 1304
                    EE +++ E   ++  AV   L  LE+        R Q  E  Q   D  + D
Sbjct: 1094 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ-AEAQQPTFD-ALRD 1151

Query: 1305 DI-----ISEKL-EAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDK 1358
            ++     + E+L +    R  ++    E     LE+   VL +TD    V Q  L +L +
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD----VRQRELEQLGR 1207

Query: 1359 QLTTYLTDRIDAFQVPQEAQKIQAEISAHELT-LEELRRNMRSQPLTSPESRTARGGSQM 1417
            QL  Y           Q+A++ Q +I A  L   + +R  +R +     E    R G ++
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKV 1265

Query: 1418 DVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDK 1477
            +  QR  +      Q      ++E +++  K  L+ V +      V+     VIQ ++D 
Sbjct: 1266 EECQRFAK------QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1319

Query: 1478 CMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQ 1537
                 +  +     ++ + +T R + ++++       ++Q    +    ++ A + + +Q
Sbjct: 1320 RTHYSELTTLTSQYIKFISETLRRMEEEERL-----AEQQRAEERERLAEVEAALEKQRQ 1374

Query: 1538 DLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKR 1597
              E  +Q   + ++EA  L + +   + E+V++  +      +D +    +++ ++L++ 
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA-----VDAQ-QQKRSIQEELQQL 1425

Query: 1598 KADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIF 1657
            +       ++ A      E S   +EE + V+                 L   + Q    
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL--------------QLEATERQRGGA 1471

Query: 1658 DGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNA 1717
            +G +  +     +AEA     +K+   ++ E ++R V +      Q E V   + +   A
Sbjct: 1472 EGELQALRARAEEAEA-----QKRQAQEEAERLRRQVQDESQRKRQAE-VELASRVKAEA 1525

Query: 1718 RGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEK 1777
              +  ++     L EL    E+  + ++ A++  A++          + E  +       
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585

Query: 1778 LENDIENMLKFVEKHL---ESSDEDEKMDEESAQIEEVLQRGEEMLHQ-PMEDNKKEKIR 1833
             E   +      E+H+   +  +E E+  ++ A+ E   +  E  L +  ++ N+  ++R
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645

Query: 1834 LQ---------LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMD 1884
            LQ         L        K +A    +R+       +R   L    L +  +  L   
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ--LAEG 1703

Query: 1885 DVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEK-------------Q 1931
              +  L   +    +  +    E   + ++++L +L  + A   +K             +
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763

Query: 1932 PDVILEASGPEAIQIRDT----LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLND 1987
             +V+L +      + R T      +L A+  R   +  +       A E  RQ      D
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823

Query: 1988 LTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLS 2047
              +   EAE +L +  A  G    E  R+ + E E+ +   +     L R  +    +  
Sbjct: 1824 AARQRAEAERVLAEKLAAIG----EATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRR 1878

Query: 2048 QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAM 2107
            + +    + K A + +R   +         R KG  +  ++ R Q++E I  L KA    
Sbjct: 1879 RLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL-KASFEK 1936

Query: 2108 QKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTV 2167
                  EL   L  +R   +      + L+   + ELE    + L+  E  +  E+   V
Sbjct: 1937 AAAGKAELELELGRIRSNAE------DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990

Query: 2168 NMTW---NKICREVPTTLKECIQEPSSVSQTR----IAAHPNVQKVVLVSSASDIPVQSH 2220
              +     +  R+    L+E  +  + V + R     A   + +++ L   A+   +Q+ 
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 2221 RTSEISIPADLDKTITE-LADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLE-- 2277
              +        ++ + + L     ++DQ+        G+ E   +     +  +   E  
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLR-------GEAEAARRAAEEAEEARVQAERE 2103

Query: 2278 --QRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVE---LRQQQLE 2332
              Q   Q++    L Q+ + +A +     A  EKL +   Q    +   E   LRQ+Q  
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163

Query: 2333 DMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVM 2392
            D      + + H++  E+ +R+   +  + Q+     L  + +D+Q  L           
Sbjct: 2164 D-----AEMEKHKKFAEQTLRQ---KAQVEQELTTLRLQLEETDHQKNL----------- 2204

Query: 2393 AFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDL 2452
              D  LQ+L  E  ++  R   +  E L +  + +++ ++  +  +EAE R +    RD 
Sbjct: 2205 -LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAENRAL--ILRDK 2259

Query: 2453 ENFLKWIQ-EAETTVNVLVDASHRENALQDSILARELKQQ---MQDIQAEIDAHNDIFKS 2508
            +N  +++Q EAE    V  +A+    A Q++   R+L ++    Q   AE        K 
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE--------KM 2311

Query: 2509 IDGNRQKMVKALGNSEEATMLQHR-----------LDDMNQRWNDLKAKSASIRAHLEAS 2557
            +    Q + +A     EA +LQ +            +D  Q    L  ++   +  LE  
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-- 2369

Query: 2558 AEKWNRLLMSLEELIKWLNMKDEELKK-QMPIGGDVPALQLQYDHC--KALRRELKEKEY 2614
            AE+  +L MS E   + L ++  E+ + Q     D    + Q +    K  R EL  +E 
Sbjct: 2370 AERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 2615 SVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES 2674
              L    + +   +D   E   E    L+ + E   +E      K+   Q+ + ++  + 
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 2675 LNAVTSNWQKQVDKALEKLRDLQ 2697
              A+  ++  + D  L++ R ++
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIE 2510



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 258/1460 (17%), Positives = 555/1460 (38%), Gaps = 213/1460 (14%)

Query: 259  TIDAIREVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDS 313
            T+  + E E L  + + E  E    +++   +     E H   +A+      E+   +  
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399

Query: 314  YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF-ATHEAFMMELTAHQSSVGSVLQA 372
              +  EE      +A D  Q++  I +++++++    A  +A   +  A + S   + + 
Sbjct: 1400 EVVRREE------AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 373  GNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSA 432
               +  Q   ++ +    + ++  L AR E    +    Q     +  ++Q +  ++  A
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLE--------EHKSLQSDLE-AEQVKVNSLTHM 483
             + L      K E     +  ++LQ L E        E +  Q+++E A QV+V   T  
Sbjct: 1514 EVELASR--VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571

Query: 484  VVIVDENSGESA-----TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQ 538
                 E   + A     TA LE  LQ   E   AV +  EE   R Q+     +   E +
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 539  CLLKAWLTEKEEALN-KVQTSNFKDQKELSVS-----------------------VRRLA 574
              L+ W  +  EAL  ++Q      QK L+ +                       VR+  
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 575  ILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQ 634
            + ++++E +RQ  +  ++      Q L   +   ++ +++E+  Q+   L + L     +
Sbjct: 1689 LAEQELEKQRQLAEGTAQ------QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742

Query: 635  VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDA 694
               A  K    Q  + +L +     E  +  K++ E       +K +  ++ EA +    
Sbjct: 1743 AAAATQK---RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR---- 1795

Query: 695  ISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQI 754
               EL     + +   +  + +  +  +D +  + + + +  E+   I  A  L    +I
Sbjct: 1796 -FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854

Query: 755  LVEQMGKEGLPTEEIKNVLEKVSSEWKNV----SQHLEDLERKI-QLQEDINAYFKQLDE 809
             +++   E    E ++ + E  + + + +    +QH  D+E ++ QL++  ++      E
Sbjct: 1855 ALKEKEAEN---ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------E 1905

Query: 810  LEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQP 869
            LE+     E+ ++     E   + + +LK S ++       L  ++   R++        
Sbjct: 1906 LERQKGLVEDTLRQRRQVE---EEILALKASFEKAAAGKAELELELGRIRSNAE------ 1956

Query: 870  SAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929
                      D+   + QA  EA   RQ   E E + +      E  + ++  L   E  
Sbjct: 1957 ----------DTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEA 2000

Query: 930  AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989
            A+     L ++ +++  ++E + L E  E +     +LA+E  A +K +  +     K  
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE--AAQKRLQAEE----KAH 2054

Query: 990  FDDVQGKWNKLKVLVSKDLHLLEEI-----ALTLRAFEADSTVIEKWMDGVKDFLMKQQA 1044
               VQ K  +L+  + ++  +L+++     A    A EA+   ++   +  +     ++A
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 1045 AQ----GDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLG 1100
             +     ++    R   Q +A     E  + + +  +  +  LR    A  +     +  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 1101 DYQT-QLEKLSKEIATQKSRLSESQ-------EKAANLKKDLAEMQEWMTQAEEEYLERD 1152
            +    Q  ++ +E+ T + +L E+        E+   LK +  E     +Q EEE     
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 1153 FEYKSPEELESAVEEMKRA----KEDVLQKEVRVKILK-DNIKLLAAKVPSGGQELTSEL 1207
             + +   +L++ +E   RA     +D  Q+ ++ +  K   +   AA++    QE     
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294

Query: 1208 NVVLENYQ----LLCNRIRGKCHTLEEVWSCWIE---LLHYLDLETTWLNTLEE-RMKST 1259
             +  E+      L    ++ K   ++E      E   L    +L       L+E + +  
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354

Query: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE 1319
            + L E+T      LE+     +   +   +   L   + +         E  + F  + E
Sbjct: 2355 QQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 1320 DL------SHLAESKQISLEKQLQVLRE-TDQMLQVLQESLGELDKQLTTYLTDRIDAFQ 1372
            ++      + LA  ++++L + L++ R+ +D   + L+E++ EL++              
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER-------------- 2457

Query: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432
               E +K+Q E    +L  EE++   + Q L   ++      S+ D L ++ R +     
Sbjct: 2458 ---EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2510

Query: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV 1492
              Q+ A  EQ   D     +  KA+     +++      Q    +  +L  ++ E +   
Sbjct: 2511 --QEKAKLEQLFQD-----EVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEARRR- 2558

Query: 1493 ETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKE 1552
                       Q +  +  +   E+L  L+         + E  Q L    QL  +  + 
Sbjct: 2559 -----------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607

Query: 1553 AASLSEWLSATETELVQ-----KSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE- 1606
            A + SE ++A++    +     +   +G   + + E S+      D  +RK     + E 
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF------DGLRRKVSAQRLQEA 2661

Query: 1607 ---SSAALQNLIEGSEPILE 1623
               S+  LQ L +G   + E
Sbjct: 2662 GILSAEELQRLAQGHTTVDE 2681



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 157/946 (16%), Positives = 366/946 (38%), Gaps = 144/946 (15%)

Query: 1800 EKMDEESAQIEEVLQRGEEMLHQPMEDNK--KEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857
            E  D   A +++  +R E++   P+ D++  +E++R +  LL       + +   QR   
Sbjct: 1214 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273

Query: 1858 QLASGIRS-SLLPTDYLVEINKIL--------------LCMDDVELSLNVPELNTAIYED 1902
            Q  + I+   L    Y  ++  +               +  + V+L  +  EL T   + 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 1903 FSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINR 1962
              F  ++L+ ++++ ++L EQ     E++    +EA+  +  Q+ +   Q  A+ +R   
Sbjct: 1334 IKFISETLRRMEEE-ERLAEQQRA-EERERLAEVEAALEKQRQLAEAHAQAKAQAER--- 1388

Query: 1963 MYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQ-EL 2021
               + K    R  EE              +   EE  VD      S+  E  ++ Q  E 
Sbjct: 1389 ---EAKELQQRMQEE--------------VVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431

Query: 2022 EVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081
            E+   + Q   A  +R       ++ +      + +  G      A+ A  ++ + + + 
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 2082 ESKQVMKYRHQLDEIICWLTKAEHAMQKR--STTELGENLQELRDLTQEMEVHAEKL-KW 2138
              ++  + R Q+ +      +AE  +  R  +  E     Q      +E+ + AE+  + 
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 2139 LNRTELEMLSDKSLSLPERDKISES-LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
            L + E+E      ++L    + +E+ L++   ++ +   ++  +L+E   E  +V+Q R 
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE---EHVAVAQLRE 1608

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257
             A    Q+            ++ R  E        +   EL  W +  ++ L+  +    
Sbjct: 1609 EAERRAQQ----------QAEAERARE--------EAERELERWQLKANEALRLRL---- 1646

Query: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQW 2317
               +  +   +  + +A+ E++  + +      +  K +  +   R    ++LE+ +   
Sbjct: 1647 ---QAEEVAQQKSLAQAEAEKQKEEAER--EARRRGKAEEQAVRQRELAEQELEKQRQLA 1701

Query: 2318 DGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRD---PLTKQI 2374
            +GT       +Q+L  +  ++ Q +  R+  EE + + +       Q R++    L K  
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761

Query: 2375 SDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADR 2434
            ++ ++LL                     +    +++R+  E +                 
Sbjct: 1762 AEMEVLLAS-------------------KARAEEESRSTSEKS----------------- 1785

Query: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
            +  LEAE    +    +        +EA+    +  + + R+ A  + +LA +L    + 
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845

Query: 2495 IQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM-NQRWNDLKAKSASIRAH 2553
             + + +A   + K  +   +++ +    +E+    + RL++   Q   D++ + A +R  
Sbjct: 1846 TRLKTEAEIAL-KEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901

Query: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRREL---- 2609
             ++  E+   L+             ++ L+++  +  ++ AL+  ++   A + EL    
Sbjct: 1902 SDSELERQKGLV-------------EDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948

Query: 2610 ---KEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS----KTELTPEERAQKIAKAMR 2662
               +      L + +QA +  A Q   A EE RR  ++    +  L  EE A +  KA  
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMK 2708
            ++   +K K E    +    +++  + L+  +  + A   L A+ K
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQAEEK 2052



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 146/749 (19%), Positives = 296/749 (39%), Gaps = 97/749 (12%)

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAE---VKDRQPRLKGESKQ 2085
            +   A L R      QK  +     L+ +LA +    + ++A     ++       +SKQ
Sbjct: 1733 EEELARLQREAAAATQKRQE-----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787

Query: 2086 VM-----KYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLN 2140
             +     ++R   +E       AE A ++R   E        R   +   V AEKL  + 
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE----DAARQRAEAERVLAEKLAAIG 1843

Query: 2141 RTELEMLSDKSLSLPERDKISESLRTV---NMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
                 + ++  ++L E++  +E LR +        +   E     K  I+E   ++Q R 
Sbjct: 1844 EAT-RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE--RLAQLRK 1900

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSE--ISIPADLDKTITELADWLVLIDQMLKSNIVT 2255
            A+   +++        D   Q  +  E  +++ A  +K     A+  + + ++  +   T
Sbjct: 1901 ASDSELERQK--GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958

Query: 2256 VGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKN 2315
            +   E+     +R +   A+ E+R  + +    + ++L  +  ++  R A  E++ER+K 
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 2316 QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQIS 2375
            + +  +   E  +Q+    +  + +    R + EE     +A  + +QQ  ++ L + + 
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAHAFAVQQKEQE-LQQTLQ 2070

Query: 2376 DNQILLQEL-GPGDGIVMAFDNVLQKLLE-EYGSDDTRNVKETTEYLKTSWINLKQSIAD 2433
              Q +L +L G  +    A +   +  ++ E  +  +R   E  E LK S     Q+ A 
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130

Query: 2434 RQNALE------------------AEWRTVQASRRDLENFLKW----------IQEAETT 2465
             Q A E                  A  R  QA+  ++E   K+          +++  TT
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190

Query: 2466 VNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSE- 2524
            + + ++ +  +  L D  L R   +  +  +       ++F S+    +++ K     E 
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKLKARIEA 2249

Query: 2525 EATMLQHRLDDMNQRWNDLKAKS----ASIRAHLEASAEKWNRLLMSLEELI-------- 2572
            E   L  R  D  QR+   +A+     A   A L  +A++  RL    EE +        
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 2573 KWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE-KEYSVLNAVDQARVFLADQP 2631
            K L  K + +++   +  +   LQ Q +  +   R L+E KE       ++ + F   + 
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF--QRT 2367

Query: 2632 IEAPEEPRRNLQSKTELTP---------EERAQKIAKAMRKQSSEVKEKWESLNAVTSNW 2682
            +EA  + +  + ++ E            + RA++ A+  RKQ+ E+ EK       T   
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--- 2424

Query: 2683 QKQVDKALEKLRDLQGAMDDLDAD-MKEA 2710
              Q    L +  ++Q    D DA+ ++EA
Sbjct: 2425 --QEKVTLVQTLEIQRQQSDHDAERLREA 2451



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 50/227 (22%), Positives = 88/227 (38%), Gaps = 9/227 (3%)

Query: 3195 EQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKS 3254
            E+   R+A+M R       D+       E+    + +    L  +  V+  Q+  +I + 
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR--TELATQEKVTLVQT-LEIQRQ 2439

Query: 3255 VEREERGELERIIADLEEEQRNLQVEYE--QLKDQHLRRGLPVGSPPES-IISPHHTSED 3311
                +   L   IA+LE E+  LQ E +  QLK + ++         E+  +     SE 
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASP 3371
              L+   + + Q K +LE   Q      +QL  +  R +Q +EQ E    +  +      
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ-ERQRLVASMEEARRR 2558

Query: 3372 QHSALSYSLDPDASGPQFHQ--AAGEDLLAPPHDTSTDLTEVMEQIH 3416
            QH A            Q  Q     E+LLA  +    +  +++E+ H
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  279 bits (713), Expect = 4e-74
 Identities = 583/2783 (20%), Positives = 1079/2783 (38%), Gaps = 414/2783 (14%)

Query: 23   KSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKER 82
            +   DE + VQKKTFTKW+N    K+ +  I+D++ DL+DG  L+ LLE L+G SLP+E+
Sbjct: 34   QDEQDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISLLEVLSGDSLPREK 92

Query: 83   GSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKD 142
            G  R H L NV   L  L    V+LVNI   DI DGN KLTLGL+W+IILH+Q+ D+   
Sbjct: 93   GRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVS 152

Query: 143  VMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKV 202
              S+   T  EK+LL W ++    Y  +   NFT+SW DG  FNA++HRHKP L   +KV
Sbjct: 153  GQSE-DMTAKEKLLL-WSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKV 210

Query: 203  VKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDA 262
             + + +E L+ AFS A+  LG+ +LLDPEDV V  PD+KSII Y++SL++ +P+      
Sbjct: 211  YRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR------ 264

Query: 263  IREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVL 322
                                             P  +      E+ +    Y+  +  +L
Sbjct: 265  --------------------------------VPDVQDGVRANELQLRWQEYRELVLLLL 292

Query: 323  TWLLSAEDTFQEQDDIS--DDVEEVKDQFATHEAFMMELTAHQS----------SVGSVL 370
             W+      F+E+   S  +++E +  QF   +   MEL A ++          S+   +
Sbjct: 293  QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE--MELPAKEADKNRSKGIYQSLEGAV 350

Query: 371  QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQLQ 428
            QAG   +  G    + E E           W  L V  ++R+ +L      +E  ++ + 
Sbjct: 351  QAGQLKVPPGYHPLDVEKE-----------WGKLHVAILEREKQLRSEFERLECLQRIVT 399

Query: 429  QLSAWLTLTEERIQKMETCPLDDDVKSLQ--KLLEEHKSLQSDLEAEQVKVNSLTHMVVI 486
            +L     L EE++ + +   L  DV+ L   K+ +    ++ DL+     +  L + V  
Sbjct: 400  KLQMEAGLCEEQLNQADAL-LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458

Query: 487  VDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLT 546
            + +        +   ++ +L ER  A+                      E    LKA + 
Sbjct: 459  LKDGRHPQGEQMYR-RVYRLHERLVAI--------------------RTEYNLRLKAGVA 497

Query: 547  EKEEALNKVQTSNFKDQKELSVS-VRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSK 605
                 + +V   + + + EL  S +R L  L   +E  +  +D  +E G D+  +     
Sbjct: 498  APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG-AEWGVDLPSVEAQLG 556

Query: 606  ASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITK 665
            + + ++   EE   +    ++R      Q++ A      ++   +D L  + ++   +  
Sbjct: 557  SHRGLHQSIEEFRAK----IERARSDEGQLSPA------TRGAYRDCLGRLDLQYAKLLN 606

Query: 666  KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS 725
             SK  L              +E+   F A + + L W+       +  E+      ++T+
Sbjct: 607  SSKARLR------------SLESLHSFVAAATKELMWL----NEKEEEEVGFDWSDRNTN 650

Query: 726  EMKKK--LKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWK-- 781
               KK    AL +E   +  +  EL   G  L+ +      PT E      +    W   
Sbjct: 651  MTAKKESYSALMRELELKEKKIKELQNAGDRLLRE-DHPARPTVESFQAALQTQWSWMLQ 709

Query: 782  ---NVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS--ESSRQSLPS 836
                +  HL++     Q   D+     QL +L++ ++ K    +  +++  E   Q    
Sbjct: 710  LCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQD 769

Query: 837  LKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLG--RYQAVQEAVE 894
             K+       +L GL      A+ + + +  +P  P    RG    L    Y+ V+  V 
Sbjct: 770  EKEQLNEYKGHLSGL------AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 823

Query: 895  DRQQHLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKT 952
                  E +L G  QP H           VL+ S ++A V     +    V    QE + 
Sbjct: 824  KGD---ECQLVGPAQPSH---------WKVLSSSGSEAAVP----SVCFLVPPPNQEAQE 867

Query: 953  LDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE 1012
                LE Q  AL  L  +       +H D++ L           W  L+    +D+ L+ 
Sbjct: 868  AVTRLEAQHQALVTLWHQ-------LHVDMKSLL---------AWQSLR----RDVQLIR 907

Query: 1013 EIAL-TLRAF--EADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQRQLDQCSAFVNE 1065
              +L T R    E     +       + FL   Q A G    D    +R+   CS   + 
Sbjct: 908  SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS---HH 964

Query: 1066 IETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQE 1125
             + +  SL+   + E+  +            + L D + QLE         + RL   +E
Sbjct: 965  YQQLLQSLEQGAQEESRCQR---------CISELKDIRLQLEACETR-TVHRLRLPLDKE 1014

Query: 1126 KAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKIL 1185
             A    + +AE Q+   QAE E L      K    L +  E                   
Sbjct: 1015 PARECAQRIAEQQK--AQAEVEGLG-----KGVARLSAEAE------------------- 1048

Query: 1186 KDNIKLLAAKVPS-GGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDL 1244
                K+LA   PS     L SEL + L           GK   +  + + ++E L  + L
Sbjct: 1049 ----KVLALPEPSPAAPTLRSELELTL-----------GKLEQVRSLSAIYLEKLKTISL 1093

Query: 1245 ETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILD 1304
                    EE +++ E   ++  AV   L  LE+        R Q  E  Q   D  + D
Sbjct: 1094 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ-AEAQQPTFD-ALRD 1151

Query: 1305 DI-----ISEKL-EAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDK 1358
            ++     + E+L +    R  ++    E     LE+   VL +TD    V Q  L +L +
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD----VRQRELEQLGR 1207

Query: 1359 QLTTYLTDRIDAFQVPQEAQKIQAEISAHELT-LEELRRNMRSQPLTSPESRTARGGSQM 1417
            QL  Y           Q+A++ Q +I A  L   + +R  +R +     E    R G ++
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKV 1265

Query: 1418 DVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDK 1477
            +  QR  +      Q      ++E +++  K  L+ V +      V+     VIQ ++D 
Sbjct: 1266 EECQRFAK------QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1319

Query: 1478 CMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQ 1537
                 +  +     ++ + +T R + ++++       ++Q    +    ++ A + + +Q
Sbjct: 1320 RTHYSELTTLTSQYIKFISETLRRMEEEERL-----AEQQRAEERERLAEVEAALEKQRQ 1374

Query: 1538 DLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKR 1597
              E  +Q   + ++EA  L + +   + E+V++  +      +D +    +++ ++L++ 
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRM---QEEVVRREEAA-----VDAQ-QQKRSIQEELQQL 1425

Query: 1598 KADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIF 1657
            +       ++ A      E S   +EE + V+                 L   + Q    
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL--------------QLEATERQRGGA 1471

Query: 1658 DGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNA 1717
            +G +  +     +AEA     +K+   ++ E ++R V +      Q E V   + +   A
Sbjct: 1472 EGELQALRARAEEAEA-----QKRQAQEEAERLRRQVQDESQRKRQAE-VELASRVKAEA 1525

Query: 1718 RGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEK 1777
              +  ++     L EL    E+  + ++ A++  A++          + E  +       
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585

Query: 1778 LENDIENMLKFVEKHL---ESSDEDEKMDEESAQIEEVLQRGEEMLHQ-PMEDNKKEKIR 1833
             E   +      E+H+   +  +E E+  ++ A+ E   +  E  L +  ++ N+  ++R
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645

Query: 1834 LQ---------LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMD 1884
            LQ         L        K +A    +R+       +R   L    L +  +  L   
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ--LAEG 1703

Query: 1885 DVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEK-------------Q 1931
              +  L   +    +  +    E   + ++++L +L  + A   +K             +
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763

Query: 1932 PDVILEASGPEAIQIRDT----LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLND 1987
             +V+L +      + R T      +L A+  R   +  +       A E  RQ      D
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823

Query: 1988 LTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLS 2047
              +   EAE +L +  A  G    E  R+ + E E+ +   +     L R  +    +  
Sbjct: 1824 AARQRAEAERVLAEKLAAIG----EATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRR 1878

Query: 2048 QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAM 2107
            + +    + K A + +R   +         R KG  +  ++ R Q++E I  L KA    
Sbjct: 1879 RLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL-KASFEK 1936

Query: 2108 QKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTV 2167
                  EL   L  +R   +      + L+   + ELE    + L+  E  +  E+   V
Sbjct: 1937 AAAGKAELELELGRIRSNAE------DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990

Query: 2168 NMTW---NKICREVPTTLKECIQEPSSVSQTR----IAAHPNVQKVVLVSSASDIPVQSH 2220
              +     +  R+    L+E  +  + V + R     A   + +++ L   A+   +Q+ 
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 2221 RTSEISIPADLDKTITE-LADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLE-- 2277
              +        ++ + + L     ++DQ+        G+ E   +     +  +   E  
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLR-------GEAEAARRAAEEAEEARVQAERE 2103

Query: 2278 --QRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVE---LRQQQLE 2332
              Q   Q++    L Q+ + +A +     A  EKL +   Q    +   E   LRQ+Q  
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163

Query: 2333 DMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVM 2392
            D      + + H++  E+ +R+   +  + Q+     L  + +D+Q  L           
Sbjct: 2164 D-----AEMEKHKKFAEQTLRQ---KAQVEQELTTLRLQLEETDHQKNL----------- 2204

Query: 2393 AFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDL 2452
              D  LQ+L  E  ++  R   +  E L +  + +++ ++  +  +EAE R +    RD 
Sbjct: 2205 -LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAENRAL--ILRDK 2259

Query: 2453 ENFLKWIQ-EAETTVNVLVDASHRENALQDSILARELKQQ---MQDIQAEIDAHNDIFKS 2508
            +N  +++Q EAE    V  +A+    A Q++   R+L ++    Q   AE        K 
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE--------KM 2311

Query: 2509 IDGNRQKMVKALGNSEEATMLQHR-----------LDDMNQRWNDLKAKSASIRAHLEAS 2557
            +    Q + +A     EA +LQ +            +D  Q    L  ++   +  LE  
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-- 2369

Query: 2558 AEKWNRLLMSLEELIKWLNMKDEELKK-QMPIGGDVPALQLQYDHC--KALRRELKEKEY 2614
            AE+  +L MS E   + L ++  E+ + Q     D    + Q +    K  R EL  +E 
Sbjct: 2370 AERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 2615 SVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES 2674
              L    + +   +D   E   E    L+ + E   +E      K+   Q+ + ++  + 
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 2675 LNAVTSNWQKQVDKALEKLRDLQ 2697
              A+  ++  + D  L++ R ++
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIE 2510



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 258/1460 (17%), Positives = 555/1460 (38%), Gaps = 213/1460 (14%)

Query: 259  TIDAIREVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDS 313
            T+  + E E L  + + E  E    +++   +     E H   +A+      E+   +  
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399

Query: 314  YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF-ATHEAFMMELTAHQSSVGSVLQA 372
              +  EE      +A D  Q++  I +++++++    A  +A   +  A + S   + + 
Sbjct: 1400 EVVRREE------AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 373  GNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSA 432
               +  Q   ++ +    + ++  L AR E    +    Q     +  ++Q +  ++  A
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLE--------EHKSLQSDLE-AEQVKVNSLTHM 483
             + L      K E     +  ++LQ L E        E +  Q+++E A QV+V   T  
Sbjct: 1514 EVELASR--VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571

Query: 484  VVIVDENSGESA-----TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQ 538
                 E   + A     TA LE  LQ   E   AV +  EE   R Q+     +   E +
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 539  CLLKAWLTEKEEALN-KVQTSNFKDQKELSVS-----------------------VRRLA 574
              L+ W  +  EAL  ++Q      QK L+ +                       VR+  
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 575  ILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQ 634
            + ++++E +RQ  +  ++      Q L   +   ++ +++E+  Q+   L + L     +
Sbjct: 1689 LAEQELEKQRQLAEGTAQ------QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742

Query: 635  VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDA 694
               A  K    Q  + +L +     E  +  K++ E       +K +  ++ EA +    
Sbjct: 1743 AAAATQK---RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR---- 1795

Query: 695  ISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQI 754
               EL     + +   +  + +  +  +D +  + + + +  E+   I  A  L    +I
Sbjct: 1796 -FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854

Query: 755  LVEQMGKEGLPTEEIKNVLEKVSSEWKNV----SQHLEDLERKI-QLQEDINAYFKQLDE 809
             +++   E    E ++ + E  + + + +    +QH  D+E ++ QL++  ++      E
Sbjct: 1855 ALKEKEAEN---ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------E 1905

Query: 810  LEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQP 869
            LE+     E+ ++     E   + + +LK S ++       L  ++   R++        
Sbjct: 1906 LERQKGLVEDTLRQRRQVE---EEILALKASFEKAAAGKAELELELGRIRSNAE------ 1956

Query: 870  SAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929
                      D+   + QA  EA   RQ   E E + +      E  + ++  L   E  
Sbjct: 1957 ----------DTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEA 2000

Query: 930  AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989
            A+     L ++ +++  ++E + L E  E +     +LA+E  A +K +  +     K  
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE--AAQKRLQAEE----KAH 2054

Query: 990  FDDVQGKWNKLKVLVSKDLHLLEEI-----ALTLRAFEADSTVIEKWMDGVKDFLMKQQA 1044
               VQ K  +L+  + ++  +L+++     A    A EA+   ++   +  +     ++A
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 1045 AQ----GDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLG 1100
             +     ++    R   Q +A     E  + + +  +  +  LR    A  +     +  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 1101 DYQT-QLEKLSKEIATQKSRLSESQ-------EKAANLKKDLAEMQEWMTQAEEEYLERD 1152
            +    Q  ++ +E+ T + +L E+        E+   LK +  E     +Q EEE     
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 1153 FEYKSPEELESAVEEMKRA----KEDVLQKEVRVKILK-DNIKLLAAKVPSGGQELTSEL 1207
             + +   +L++ +E   RA     +D  Q+ ++ +  K   +   AA++    QE     
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294

Query: 1208 NVVLENYQ----LLCNRIRGKCHTLEEVWSCWIE---LLHYLDLETTWLNTLEE-RMKST 1259
             +  E+      L    ++ K   ++E      E   L    +L       L+E + +  
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354

Query: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE 1319
            + L E+T      LE+     +   +   +   L   + +         E  + F  + E
Sbjct: 2355 QQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 1320 DL------SHLAESKQISLEKQLQVLRE-TDQMLQVLQESLGELDKQLTTYLTDRIDAFQ 1372
            ++      + LA  ++++L + L++ R+ +D   + L+E++ EL++              
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER-------------- 2457

Query: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432
               E +K+Q E    +L  EE++   + Q L   ++      S+ D L ++ R +     
Sbjct: 2458 ---EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2510

Query: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV 1492
              Q+ A  EQ   D     +  KA+     +++      Q    +  +L  ++ E +   
Sbjct: 2511 --QEKAKLEQLFQD-----EVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEARRR- 2558

Query: 1493 ETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKE 1552
                       Q +  +  +   E+L  L+         + E  Q L    QL  +  + 
Sbjct: 2559 -----------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607

Query: 1553 AASLSEWLSATETELVQ-----KSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE- 1606
            A + SE ++A++    +     +   +G   + + E S+      D  +RK     + E 
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF------DGLRRKVSAQRLQEA 2661

Query: 1607 ---SSAALQNLIEGSEPILE 1623
               S+  LQ L +G   + E
Sbjct: 2662 GILSAEELQRLAQGHTTVDE 2681



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 157/946 (16%), Positives = 366/946 (38%), Gaps = 144/946 (15%)

Query: 1800 EKMDEESAQIEEVLQRGEEMLHQPMEDNK--KEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857
            E  D   A +++  +R E++   P+ D++  +E++R +  LL       + +   QR   
Sbjct: 1214 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273

Query: 1858 QLASGIRS-SLLPTDYLVEINKIL--------------LCMDDVELSLNVPELNTAIYED 1902
            Q  + I+   L    Y  ++  +               +  + V+L  +  EL T   + 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 1903 FSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINR 1962
              F  ++L+ ++++ ++L EQ     E++    +EA+  +  Q+ +   Q  A+ +R   
Sbjct: 1334 IKFISETLRRMEEE-ERLAEQQRA-EERERLAEVEAALEKQRQLAEAHAQAKAQAER--- 1388

Query: 1963 MYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQ-EL 2021
               + K    R  EE              +   EE  VD      S+  E  ++ Q  E 
Sbjct: 1389 ---EAKELQQRMQEE--------------VVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431

Query: 2022 EVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081
            E+   + Q   A  +R       ++ +      + +  G      A+ A  ++ + + + 
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 2082 ESKQVMKYRHQLDEIICWLTKAEHAMQKR--STTELGENLQELRDLTQEMEVHAEKL-KW 2138
              ++  + R Q+ +      +AE  +  R  +  E     Q      +E+ + AE+  + 
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 2139 LNRTELEMLSDKSLSLPERDKISES-LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
            L + E+E      ++L    + +E+ L++   ++ +   ++  +L+E   E  +V+Q R 
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE---EHVAVAQLRE 1608

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257
             A    Q+            ++ R  E        +   EL  W +  ++ L+  +    
Sbjct: 1609 EAERRAQQ----------QAEAERARE--------EAERELERWQLKANEALRLRL---- 1646

Query: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQW 2317
               +  +   +  + +A+ E++  + +      +  K +  +   R    ++LE+ +   
Sbjct: 1647 ---QAEEVAQQKSLAQAEAEKQKEEAER--EARRRGKAEEQAVRQRELAEQELEKQRQLA 1701

Query: 2318 DGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRD---PLTKQI 2374
            +GT       +Q+L  +  ++ Q +  R+  EE + + +       Q R++    L K  
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761

Query: 2375 SDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADR 2434
            ++ ++LL                     +    +++R+  E +                 
Sbjct: 1762 AEMEVLLAS-------------------KARAEEESRSTSEKS----------------- 1785

Query: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
            +  LEAE    +    +        +EA+    +  + + R+ A  + +LA +L    + 
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845

Query: 2495 IQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM-NQRWNDLKAKSASIRAH 2553
             + + +A   + K  +   +++ +    +E+    + RL++   Q   D++ + A +R  
Sbjct: 1846 TRLKTEAEIAL-KEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901

Query: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRREL---- 2609
             ++  E+   L+             ++ L+++  +  ++ AL+  ++   A + EL    
Sbjct: 1902 SDSELERQKGLV-------------EDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948

Query: 2610 ---KEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS----KTELTPEERAQKIAKAMR 2662
               +      L + +QA +  A Q   A EE RR  ++    +  L  EE A +  KA  
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMK 2708
            ++   +K K E    +    +++  + L+  +  + A   L A+ K
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQAEEK 2052



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 146/749 (19%), Positives = 296/749 (39%), Gaps = 97/749 (12%)

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAE---VKDRQPRLKGESKQ 2085
            +   A L R      QK  +     L+ +LA +    + ++A     ++       +SKQ
Sbjct: 1733 EEELARLQREAAAATQKRQE-----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787

Query: 2086 VM-----KYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLN 2140
             +     ++R   +E       AE A ++R   E        R   +   V AEKL  + 
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE----DAARQRAEAERVLAEKLAAIG 1843

Query: 2141 RTELEMLSDKSLSLPERDKISESLRTV---NMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
                 + ++  ++L E++  +E LR +        +   E     K  I+E   ++Q R 
Sbjct: 1844 EAT-RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE--RLAQLRK 1900

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSE--ISIPADLDKTITELADWLVLIDQMLKSNIVT 2255
            A+   +++        D   Q  +  E  +++ A  +K     A+  + + ++  +   T
Sbjct: 1901 ASDSELERQK--GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958

Query: 2256 VGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKN 2315
            +   E+     +R +   A+ E+R  + +    + ++L  +  ++  R A  E++ER+K 
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 2316 QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQIS 2375
            + +  +   E  +Q+    +  + +    R + EE     +A  + +QQ  ++ L + + 
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAHAFAVQQKEQE-LQQTLQ 2070

Query: 2376 DNQILLQEL-GPGDGIVMAFDNVLQKLLE-EYGSDDTRNVKETTEYLKTSWINLKQSIAD 2433
              Q +L +L G  +    A +   +  ++ E  +  +R   E  E LK S     Q+ A 
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130

Query: 2434 RQNALE------------------AEWRTVQASRRDLENFLKW----------IQEAETT 2465
             Q A E                  A  R  QA+  ++E   K+          +++  TT
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190

Query: 2466 VNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSE- 2524
            + + ++ +  +  L D  L R   +  +  +       ++F S+    +++ K     E 
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKLKARIEA 2249

Query: 2525 EATMLQHRLDDMNQRWNDLKAKS----ASIRAHLEASAEKWNRLLMSLEELI-------- 2572
            E   L  R  D  QR+   +A+     A   A L  +A++  RL    EE +        
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 2573 KWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE-KEYSVLNAVDQARVFLADQP 2631
            K L  K + +++   +  +   LQ Q +  +   R L+E KE       ++ + F   + 
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF--QRT 2367

Query: 2632 IEAPEEPRRNLQSKTELTP---------EERAQKIAKAMRKQSSEVKEKWESLNAVTSNW 2682
            +EA  + +  + ++ E            + RA++ A+  RKQ+ E+ EK       T   
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--- 2424

Query: 2683 QKQVDKALEKLRDLQGAMDDLDAD-MKEA 2710
              Q    L +  ++Q    D DA+ ++EA
Sbjct: 2425 --QEKVTLVQTLEIQRQQSDHDAERLREA 2451



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 50/227 (22%), Positives = 88/227 (38%), Gaps = 9/227 (3%)

Query: 3195 EQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKS 3254
            E+   R+A+M R       D+       E+    + +    L  +  V+  Q+  +I + 
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR--TELATQEKVTLVQT-LEIQRQ 2439

Query: 3255 VEREERGELERIIADLEEEQRNLQVEYE--QLKDQHLRRGLPVGSPPES-IISPHHTSED 3311
                +   L   IA+LE E+  LQ E +  QLK + ++         E+  +     SE 
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASP 3371
              L+   + + Q K +LE   Q      +QL  +  R +Q +EQ E    +  +      
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ-ERQRLVASMEEARRR 2558

Query: 3372 QHSALSYSLDPDASGPQFHQ--AAGEDLLAPPHDTSTDLTEVMEQIH 3416
            QH A            Q  Q     E+LLA  +    +  +++E+ H
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  279 bits (713), Expect = 4e-74
 Identities = 583/2780 (20%), Positives = 1079/2780 (38%), Gaps = 414/2780 (14%)

Query: 26   SDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGST 85
            +DE + VQKKTFTKW+N    K+ +  I+D++ DL+DG  L+ LLE L+G SLP+E+G  
Sbjct: 174  TDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 232

Query: 86   RVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMS 145
            R H L NV   L  L    V+LVNI   DI DGN KLTLGL+W+IILH+Q+ D+     S
Sbjct: 233  RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 292

Query: 146  DLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKM 205
            +   T  EK+LL W ++    Y  +   NFT+SW DG  FNA++HRHKP L   +KV + 
Sbjct: 293  E-DMTAKEKLLL-WSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 350

Query: 206  SPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIRE 265
            + +E L+ AFS A+  LG+ +LLDPEDV V  PD+KSII Y++SL++ +P+         
Sbjct: 351  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR--------- 401

Query: 266  VETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWL 325
                                          P  +      E+ +    Y+  +  +L W+
Sbjct: 402  -----------------------------VPDVQDGVRANELQLRWQEYRELVLLLLQWM 432

Query: 326  LSAEDTFQEQDDIS--DDVEEVKDQFATHEAFMMELTAHQS----------SVGSVLQAG 373
                  F+E+   S  +++E +  QF   +   MEL A ++          S+   +QAG
Sbjct: 433  RHHTAAFEERRFPSSFEEIEILWSQFLKFKE--MELPAKEADKNRSKGIYQSLEGAVQAG 490

Query: 374  NQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQLQQLS 431
               +  G    + E E           W  L V  ++R+ +L      +E  ++ + +L 
Sbjct: 491  QLKVPPGYHPLDVEKE-----------WGKLHVAILEREKQLRSEFERLECLQRIVTKLQ 539

Query: 432  AWLTLTEERIQKMETCPLDDDVKSLQ--KLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE 489
                L EE++ + +   L  DV+ L   K+ +    ++ DL+     +  L + V  + +
Sbjct: 540  MEAGLCEEQLNQADAL-LQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD 598

Query: 490  NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
                    +   ++ +L ER  A+                      E    LKA +    
Sbjct: 599  GRHPQGEQMYR-RVYRLHERLVAI--------------------RTEYNLRLKAGVAAPA 637

Query: 550  EALNKVQTSNFKDQKELSVS-VRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASK 608
              + +V   + + + EL  S +R L  L   +E  +  +D  +E G D+  +     + +
Sbjct: 638  TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG-AEWGVDLPSVEAQLGSHR 696

Query: 609  KINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSK 668
             ++   EE   +    ++R      Q++ A      ++   +D L  + ++   +   SK
Sbjct: 697  GLHQSIEEFRAK----IERARSDEGQLSPA------TRGAYRDCLGRLDLQYAKLLNSSK 746

Query: 669  QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMK 728
              L              +E+   F A + + L W+       +  E+      ++T+   
Sbjct: 747  ARLR------------SLESLHSFVAAATKELMWL----NEKEEEEVGFDWSDRNTNMTA 790

Query: 729  KK--LKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWK----- 781
            KK    AL +E   +  +  EL   G  L+ +      PT E      +    W      
Sbjct: 791  KKESYSALMRELELKEKKIKELQNAGDRLLRE-DHPARPTVESFQAALQTQWSWMLQLCC 849

Query: 782  NVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS--ESSRQSLPSLKD 839
             +  HL++     Q   D+     QL +L++ ++ K    +  +++  E   Q     K+
Sbjct: 850  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKE 909

Query: 840  SCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLG--RYQAVQEAVEDRQ 897
                   +L GL      A+ + + +  +P  P    RG    L    Y+ V+  V    
Sbjct: 910  QLNEYKGHLSGL------AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD 963

Query: 898  QHLENELKG--QPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDE 955
               E +L G  QP H           VL+ S ++A V     +    V    QE +    
Sbjct: 964  ---ECQLVGPAQPSH---------WKVLSSSGSEAAVP----SVCFLVPPPNQEAQEAVT 1007

Query: 956  ILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIA 1015
             LE Q  AL  L  +       +H D++ L           W  L+    +D+ L+   +
Sbjct: 1008 RLEAQHQALVTLWHQ-------LHVDMKSLL---------AWQSLR----RDVQLIRSWS 1047

Query: 1016 L-TLRAF--EADSTVIEKWMDGVKDFLMKQQAAQG----DDAGLQRQLDQCSAFVNEIET 1068
            L T R    E     +       + FL   Q A G    D    +R+   CS   +  + 
Sbjct: 1048 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS---HHYQQ 1104

Query: 1069 IESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAA 1128
            +  SL+   + E+  +            + L D + QLE         + RL   +E A 
Sbjct: 1105 LLQSLEQGAQEESRCQR---------CISELKDIRLQLEACETR-TVHRLRLPLDKEPAR 1154

Query: 1129 NLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDN 1188
               + +AE Q+   QAE E L      K    L +  E                      
Sbjct: 1155 ECAQRIAEQQK--AQAEVEGLG-----KGVARLSAEAE---------------------- 1185

Query: 1189 IKLLAAKVPS-GGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETT 1247
             K+LA   PS     L SEL + L           GK   +  + + ++E L  + L   
Sbjct: 1186 -KVLALPEPSPAAPTLRSELELTL-----------GKLEQVRSLSAIYLEKLKTISLVIR 1233

Query: 1248 WLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDI- 1306
                 EE +++ E   ++  AV   L  LE+        R Q  E  Q   D  + D++ 
Sbjct: 1234 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ-AEAQQPTFD-ALRDELR 1291

Query: 1307 ----ISEKL-EAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLT 1361
                + E+L +    R  ++    E     LE+   VL +TD    V Q  L +L +QL 
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD----VRQRELEQLGRQLR 1347

Query: 1362 TYLTDRIDAFQVPQEAQKIQAEISAHELT-LEELRRNMRSQPLTSPESRTARGGSQMDVL 1420
             Y           Q+A++ Q +I A  L   + +R  +R +     E    R G +++  
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEEC 1405

Query: 1421 QRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMK 1480
            QR  +      Q      ++E +++  K  L+ V +      V+     VIQ ++D    
Sbjct: 1406 QRFAK------QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459

Query: 1481 LYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLE 1540
              +  +     ++ + +T R + ++++       ++Q    +    ++ A + + +Q  E
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEEEERL-----AEQQRAEERERLAEVEAALEKQRQLAE 1514

Query: 1541 RASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKAD 1600
              +Q   + ++EA  L + +   + E+V++  +      +D +    +++ ++L++ +  
Sbjct: 1515 AHAQAKAQAEREAKELQQRM---QEEVVRREEAA-----VDAQ-QQKRSIQEELQQLRQS 1565

Query: 1601 LNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGN 1660
                 ++ A      E S   +EE + V+                 L   + Q    +G 
Sbjct: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVVRL--------------QLEATERQRGGAEGE 1611

Query: 1661 VAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGS 1720
            +  +     +AEA     +K+   ++ E ++R V +      Q E V   + +   A  +
Sbjct: 1612 LQALRARAEEAEA-----QKRQAQEEAERLRRQVQDESQRKRQAE-VELASRVKAEAEAA 1665

Query: 1721 SSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN 1780
              ++     L EL    E+  + ++ A++  A++          + E  +        E 
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 1781 DIENMLKFVEKHL---ESSDEDEKMDEESAQIEEVLQRGEEMLHQ-PMEDNKKEKIRLQ- 1835
              +      E+H+   +  +E E+  ++ A+ E   +  E  L +  ++ N+  ++RLQ 
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785

Query: 1836 --------LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVE 1887
                    L        K +A    +R+       +R   L    L +  +  L     +
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ--LAEGTAQ 1843

Query: 1888 LSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEK-------------QPDV 1934
              L   +    +  +    E   + ++++L +L  + A   +K             + +V
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903

Query: 1935 ILEASGPEAIQIRDT----LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQ 1990
            +L +      + R T      +L A+  R   +  +       A E  RQ      D  +
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1963

Query: 1991 WITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQAD 2050
               EAE +L +  A  G    E  R+ + E E+ +   +     L R  +    +  + +
Sbjct: 1964 QRAEAERVLAEKLAAIG----EATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 2018

Query: 2051 GSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKR 2110
                + K A + +R   +         R KG  +  ++ R Q++E I  L KA       
Sbjct: 2019 EQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL-KASFEKAAA 2076

Query: 2111 STTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMT 2170
               EL   L  +R   +      + L+   + ELE    + L+  E  +  E+   V  +
Sbjct: 2077 GKAELELELGRIRSNAE------DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130

Query: 2171 W---NKICREVPTTLKECIQEPSSVSQTR----IAAHPNVQKVVLVSSASDIPVQSHRTS 2223
                 +  R+    L+E  +  + V + R     A   + +++ L   A+   +Q+   +
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190

Query: 2224 EISIPADLDKTITE-LADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLE----Q 2278
                    ++ + + L     ++DQ+        G+ E   +     +  +   E    Q
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLR-------GEAEAARRAAEEAEEARVQAEREAAQ 2243

Query: 2279 RHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVE---LRQQQLEDMI 2335
               Q++    L Q+ + +A +     A  EKL +   Q    +   E   LRQ+Q  D  
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD-- 2301

Query: 2336 IDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFD 2395
                + + H++  E+ +R+   +  + Q+     L  + +D+Q  L             D
Sbjct: 2302 ---AEMEKHKKFAEQTLRQ---KAQVEQELTTLRLQLEETDHQKNL------------LD 2343

Query: 2396 NVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENF 2455
              LQ+L  E  ++  R   +  E L +  + +++ ++  +  +EAE R +    RD +N 
Sbjct: 2344 EELQRLKAE-ATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAENRAL--ILRDKDNT 2399

Query: 2456 LKWIQ-EAETTVNVLVDASHRENALQDSILARELKQQ---MQDIQAEIDAHNDIFKSIDG 2511
             +++Q EAE    V  +A+    A Q++   R+L ++    Q   AE        K +  
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE--------KMLKE 2451

Query: 2512 NRQKMVKALGNSEEATMLQHR-----------LDDMNQRWNDLKAKSASIRAHLEASAEK 2560
              Q + +A     EA +LQ +            +D  Q    L  ++   +  LE  AE+
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AER 2509

Query: 2561 WNRLLMSLEELIKWLNMKDEELKK-QMPIGGDVPALQLQYDHC--KALRRELKEKEYSVL 2617
              +L MS E   + L ++  E+ + Q     D    + Q +    K  R EL  +E   L
Sbjct: 2510 QRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567

Query: 2618 NAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNA 2677
                + +   +D   E   E    L+ + E   +E      K+   Q+ + ++  +   A
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627

Query: 2678 VTSNWQKQVDKALEKLRDLQ 2697
            +  ++  + D  L++ R ++
Sbjct: 2628 LQQSFLSEKDSLLQRERFIE 2647



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 258/1460 (17%), Positives = 555/1460 (38%), Gaps = 213/1460 (14%)

Query: 259  TIDAIREVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDS 313
            T+  + E E L  + + E  E    +++   +     E H   +A+      E+   +  
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1536

Query: 314  YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQF-ATHEAFMMELTAHQSSVGSVLQA 372
              +  EE      +A D  Q++  I +++++++    A  +A   +  A + S   + + 
Sbjct: 1537 EVVRREE------AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590

Query: 373  GNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSA 432
               +  Q   ++ +    + ++  L AR E    +    Q     +  ++Q +  ++  A
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650

Query: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLE--------EHKSLQSDLE-AEQVKVNSLTHM 483
             + L      K E     +  ++LQ L E        E +  Q+++E A QV+V   T  
Sbjct: 1651 EVELASR--VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708

Query: 484  VVIVDENSGESA-----TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQ 538
                 E   + A     TA LE  LQ   E   AV +  EE   R Q+     +   E +
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAE 1765

Query: 539  CLLKAWLTEKEEALN-KVQTSNFKDQKELSVS-----------------------VRRLA 574
              L+ W  +  EAL  ++Q      QK L+ +                       VR+  
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825

Query: 575  ILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQ 634
            + ++++E +RQ  +  ++      Q L   +   ++ +++E+  Q+   L + L     +
Sbjct: 1826 LAEQELEKQRQLAEGTAQ------QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879

Query: 635  VTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDA 694
               A  K    Q  + +L +     E  +  K++ E       +K +  ++ EA +    
Sbjct: 1880 AAAATQK---RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR---- 1932

Query: 695  ISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQI 754
               EL     + +   +  + +  +  +D +  + + + +  E+   I  A  L    +I
Sbjct: 1933 -FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991

Query: 755  LVEQMGKEGLPTEEIKNVLEKVSSEWKNV----SQHLEDLERKI-QLQEDINAYFKQLDE 809
             +++   E    E ++ + E  + + + +    +QH  D+E ++ QL++  ++      E
Sbjct: 1992 ALKEKEAEN---ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------E 2042

Query: 810  LEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQP 869
            LE+     E+ ++     E   + + +LK S ++       L  ++   R++        
Sbjct: 2043 LERQKGLVEDTLRQRRQVE---EEILALKASFEKAAAGKAELELELGRIRSNAE------ 2093

Query: 870  SAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929
                      D+   + QA  EA   RQ   E E + +      E  + ++  L   E  
Sbjct: 2094 ----------DTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEA 2137

Query: 930  AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989
            A+     L ++ +++  ++E + L E  E +     +LA+E  A +K +  +     K  
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE--AAQKRLQAEE----KAH 2191

Query: 990  FDDVQGKWNKLKVLVSKDLHLLEEI-----ALTLRAFEADSTVIEKWMDGVKDFLMKQQA 1044
               VQ K  +L+  + ++  +L+++     A    A EA+   ++   +  +     ++A
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251

Query: 1045 AQ----GDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLG 1100
             +     ++    R   Q +A     E  + + +  +  +  LR    A  +     +  
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311

Query: 1101 DYQT-QLEKLSKEIATQKSRLSESQ-------EKAANLKKDLAEMQEWMTQAEEEYLERD 1152
            +    Q  ++ +E+ T + +L E+        E+   LK +  E     +Q EEE     
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 1153 FEYKSPEELESAVEEMKRA----KEDVLQKEVRVKILK-DNIKLLAAKVPSGGQELTSEL 1207
             + +   +L++ +E   RA     +D  Q+ ++ +  K   +   AA++    QE     
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431

Query: 1208 NVVLENYQ----LLCNRIRGKCHTLEEVWSCWIE---LLHYLDLETTWLNTLEE-RMKST 1259
             +  E+      L    ++ K   ++E      E   L    +L       L+E + +  
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491

Query: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE 1319
            + L E+T      LE+     +   +   +   L   + +         E  + F  + E
Sbjct: 2492 QQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548

Query: 1320 DL------SHLAESKQISLEKQLQVLRE-TDQMLQVLQESLGELDKQLTTYLTDRIDAFQ 1372
            ++      + LA  ++++L + L++ R+ +D   + L+E++ EL++              
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER-------------- 2594

Query: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432
               E +K+Q E    +L  EE++   + Q L   ++      S+ D L ++ R +     
Sbjct: 2595 ---EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2647

Query: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV 1492
              Q+ A  EQ   D     +  KA+     +++      Q    +  +L  ++ E +   
Sbjct: 2648 --QEKAKLEQLFQD-----EVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEARRR- 2695

Query: 1493 ETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKE 1552
                       Q +  +  +   E+L  L+         + E  Q L    QL  +  + 
Sbjct: 2696 -----------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744

Query: 1553 AASLSEWLSATETELVQ-----KSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE- 1606
            A + SE ++A++    +     +   +G   + + E S+      D  +RK     + E 
Sbjct: 2745 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF------DGLRRKVSAQRLQEA 2798

Query: 1607 ---SSAALQNLIEGSEPILE 1623
               S+  LQ L +G   + E
Sbjct: 2799 GILSAEELQRLAQGHTTVDE 2818



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 157/946 (16%), Positives = 366/946 (38%), Gaps = 144/946 (15%)

Query: 1800 EKMDEESAQIEEVLQRGEEMLHQPMEDNK--KEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857
            E  D   A +++  +R E++   P+ D++  +E++R +  LL       + +   QR   
Sbjct: 1351 ESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1410

Query: 1858 QLASGIRS-SLLPTDYLVEINKIL--------------LCMDDVELSLNVPELNTAIYED 1902
            Q  + I+   L    Y  ++  +               +  + V+L  +  EL T   + 
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470

Query: 1903 FSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINR 1962
              F  ++L+ ++++ ++L EQ     E++    +EA+  +  Q+ +   Q  A+ +R   
Sbjct: 1471 IKFISETLRRMEEE-ERLAEQQRA-EERERLAEVEAALEKQRQLAEAHAQAKAQAER--- 1525

Query: 1963 MYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQ-EL 2021
               + K    R  EE              +   EE  VD      S+  E  ++ Q  E 
Sbjct: 1526 ---EAKELQQRMQEE--------------VVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1568

Query: 2022 EVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081
            E+   + Q   A  +R       ++ +      + +  G      A+ A  ++ + + + 
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628

Query: 2082 ESKQVMKYRHQLDEIICWLTKAEHAMQKR--STTELGENLQELRDLTQEMEVHAEKL-KW 2138
              ++  + R Q+ +      +AE  +  R  +  E     Q      +E+ + AE+  + 
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688

Query: 2139 LNRTELEMLSDKSLSLPERDKISES-LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
            L + E+E      ++L    + +E+ L++   ++ +   ++  +L+E   E  +V+Q R 
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE---EHVAVAQLRE 1745

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257
             A    Q+            ++ R  E        +   EL  W +  ++ L+  +    
Sbjct: 1746 EAERRAQQ----------QAEAERARE--------EAERELERWQLKANEALRLRL---- 1783

Query: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQW 2317
               +  +   +  + +A+ E++  + +      +  K +  +   R    ++LE+ +   
Sbjct: 1784 ---QAEEVAQQKSLAQAEAEKQKEEAER--EARRRGKAEEQAVRQRELAEQELEKQRQLA 1838

Query: 2318 DGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRD---PLTKQI 2374
            +GT       +Q+L  +  ++ Q +  R+  EE + + +       Q R++    L K  
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1898

Query: 2375 SDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADR 2434
            ++ ++LL                     +    +++R+  E +                 
Sbjct: 1899 AEMEVLLAS-------------------KARAEEESRSTSEKS----------------- 1922

Query: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
            +  LEAE    +    +        +EA+    +  + + R+ A  + +LA +L    + 
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982

Query: 2495 IQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM-NQRWNDLKAKSASIRAH 2553
             + + +A   + K  +   +++ +    +E+    + RL++   Q   D++ + A +R  
Sbjct: 1983 TRLKTEAEIAL-KEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038

Query: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRREL---- 2609
             ++  E+   L+             ++ L+++  +  ++ AL+  ++   A + EL    
Sbjct: 2039 SDSELERQKGLV-------------EDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 2085

Query: 2610 ---KEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS----KTELTPEERAQKIAKAMR 2662
               +      L + +QA +  A Q   A EE RR  ++    +  L  EE A +  KA  
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMK 2708
            ++   +K K E    +    +++  + L+  +  + A   L A+ K
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQAEEK 2189



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 146/749 (19%), Positives = 296/749 (39%), Gaps = 97/749 (12%)

Query: 2029 QPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAE---VKDRQPRLKGESKQ 2085
            +   A L R      QK  +     L+ +LA +    + ++A     ++       +SKQ
Sbjct: 1870 EEELARLQREAAAATQKRQE-----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924

Query: 2086 VM-----KYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLN 2140
             +     ++R   +E       AE A ++R   E        R   +   V AEKL  + 
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE----DAARQRAEAERVLAEKLAAIG 1980

Query: 2141 RTELEMLSDKSLSLPERDKISESLRTV---NMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
                 + ++  ++L E++  +E LR +        +   E     K  I+E   ++Q R 
Sbjct: 1981 EAT-RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE--RLAQLRK 2037

Query: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSE--ISIPADLDKTITELADWLVLIDQMLKSNIVT 2255
            A+   +++        D   Q  +  E  +++ A  +K     A+  + + ++  +   T
Sbjct: 2038 ASDSELERQK--GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095

Query: 2256 VGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKN 2315
            +   E+     +R +   A+ E+R  + +    + ++L  +  ++  R A  E++ER+K 
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKA 2153

Query: 2316 QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQIS 2375
            + +  +   E  +Q+    +  + +    R + EE     +A  + +QQ  ++ L + + 
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAHAFAVQQKEQE-LQQTLQ 2207

Query: 2376 DNQILLQEL-GPGDGIVMAFDNVLQKLLE-EYGSDDTRNVKETTEYLKTSWINLKQSIAD 2433
              Q +L +L G  +    A +   +  ++ E  +  +R   E  E LK S     Q+ A 
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267

Query: 2434 RQNALE------------------AEWRTVQASRRDLENFLKW----------IQEAETT 2465
             Q A E                  A  R  QA+  ++E   K+          +++  TT
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327

Query: 2466 VNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSE- 2524
            + + ++ +  +  L D  L R   +  +  +       ++F S+    +++ K     E 
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF-SVRVQMEELSKLKARIEA 2386

Query: 2525 EATMLQHRLDDMNQRWNDLKAKS----ASIRAHLEASAEKWNRLLMSLEELI-------- 2572
            E   L  R  D  QR+   +A+     A   A L  +A++  RL    EE +        
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446

Query: 2573 KWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE-KEYSVLNAVDQARVFLADQP 2631
            K L  K + +++   +  +   LQ Q +  +   R L+E KE       ++ + F   + 
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF--QRT 2504

Query: 2632 IEAPEEPRRNLQSKTELTP---------EERAQKIAKAMRKQSSEVKEKWESLNAVTSNW 2682
            +EA  + +  + ++ E            + RA++ A+  RKQ+ E+ EK       T   
Sbjct: 2505 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--- 2561

Query: 2683 QKQVDKALEKLRDLQGAMDDLDAD-MKEA 2710
              Q    L +  ++Q    D DA+ ++EA
Sbjct: 2562 --QEKVTLVQTLEIQRQQSDHDAERLREA 2588



 Score = 36.2 bits (82), Expect = 0.58
 Identities = 50/227 (22%), Positives = 88/227 (38%), Gaps = 9/227 (3%)

Query: 3195 EQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKS 3254
            E+   R+A+M R       D+       E+    + +    L  +  V+  Q+  +I + 
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR--TELATQEKVTLVQT-LEIQRQ 2576

Query: 3255 VEREERGELERIIADLEEEQRNLQVEYE--QLKDQHLRRGLPVGSPPES-IISPHHTSED 3311
                +   L   IA+LE E+  LQ E +  QLK + ++         E+  +     SE 
Sbjct: 2577 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2636

Query: 3312 SELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASP 3371
              L+   + + Q K +LE   Q      +QL  +  R +Q +EQ E    +  +      
Sbjct: 2637 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ-ERQRLVASMEEARRR 2695

Query: 3372 QHSALSYSLDPDASGPQFHQ--AAGEDLLAPPHDTSTDLTEVMEQIH 3416
            QH A            Q  Q     E+LLA  +    +  +++E+ H
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 123,584,975
Number of Sequences: 37866
Number of extensions: 5540474
Number of successful extensions: 37232
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 207
Number of HSP's successfully gapped in prelim test: 857
Number of HSP's that attempted gapping in prelim test: 22567
Number of HSP's gapped (non-prelim): 8662
length of query: 3433
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3312
effective length of database: 13,665,732
effective search space: 45260904384
effective search space used: 45260904384
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.