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Search of human proteins with 164663798
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
(258 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 523 e-149
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 96 4e-20
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 92 4e-19
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 74 2e-13
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 71 8e-13
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 69 3e-12
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 69 5e-12
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 66 3e-11
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 57 2e-08
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 54 1e-07
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 54 1e-07
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 53 2e-07
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 49 6e-06
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 43 3e-04
gi|169160755 PREDICTED: zyg-11 homolog A (C. elegans) [Homo sapi... 41 0.001
gi|88948888 PREDICTED: zyg-11 homolog A (C. elegans) [Homo sapiens] 41 0.001
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 41 0.001
gi|113408672 PREDICTED: zyg-11 homolog A [Homo sapiens] 40 0.003
gi|226437632 zyg-11 homolog A [Homo sapiens] 40 0.003
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 35 0.050
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 35 0.050
gi|46249373 preferentially expressed antigen in melanoma [Homo s... 35 0.065
gi|46249371 preferentially expressed antigen in melanoma [Homo s... 35 0.065
gi|46249369 preferentially expressed antigen in melanoma [Homo s... 35 0.065
gi|46249367 preferentially expressed antigen in melanoma [Homo s... 35 0.065
gi|5174641 preferentially expressed antigen in melanoma [Homo sa... 35 0.065
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 34 0.14
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 34 0.14
gi|28416956 GTPase, IMAP family member 8 [Homo sapiens] 34 0.14
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 33 0.25
>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
Length = 258
Score = 523 bits (1348), Expect = e-149
Identities = 258/258 (100%), Positives = 258/258 (100%)
Query: 1 MPRPRRVSQLLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSMQGQITDSNISEILH 60
MPRPRRVSQLLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSMQGQITDSNISEILH
Sbjct: 1 MPRPRRVSQLLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSMQGQITDSNISEILH 60
Query: 61 PEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEA 120
PEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEA
Sbjct: 61 PEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEA 120
Query: 121 SLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVS 180
SLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVS
Sbjct: 121 SLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVS 180
Query: 181 DSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREV 240
DSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREV
Sbjct: 181 DSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREV 240
Query: 241 LEQLVGPNKLKQVTWTVY 258
LEQLVGPNKLKQVTWTVY
Sbjct: 241 LEQLVGPNKLKQVTWTVY 258
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 95.5 bits (236), Expect = 4e-20
Identities = 70/230 (30%), Positives = 118/230 (51%), Gaps = 39/230 (16%)
Query: 39 RLIKIMSMQG--QITDSNISEILH--PEVQTLDLRSC-DISDAALLHLSN-CRKLKKLNL 92
R I+ +++ G +ITDS + +++ LDL SC I++++L +S CR L+ LNL
Sbjct: 104 RNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNL 163
Query: 93 NASKGNRVSVTSEGIKAVASSC-----------------------SYLHEA---SLKRCC 126
+ +T +GI+A+ C +Y HE +L+ C
Sbjct: 164 SWCD----QITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCS 219
Query: 127 NLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-ATQVSDSGVI 185
+TDEGVV + C L+ + L GC ++TD SL ALG NCP LQ ++ + + ++D+G
Sbjct: 220 RITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFT 279
Query: 186 ALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
L +LE++ + C+ +TD + + +CP+++ L C LITD
Sbjct: 280 LLARN--CHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITD 327
Score = 92.8 bits (229), Expect = 3e-19
Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 12/215 (5%)
Query: 44 MSMQGQITDSNISEILHP--EVQTLDLRSC-DISDAALLHLSN-CRKLKKLNLNASKGNR 99
+S QIT I ++ ++ L LR C + D AL H+ N C +L LNL +
Sbjct: 163 LSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCS--- 219
Query: 100 VSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSL 159
+T EG+ + C L L C NLTD + AL LNC L+I++ C +TD
Sbjct: 220 -RITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGF 278
Query: 160 HALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTD-GAVEAVLTY 218
L +NC L+ +D + + +S C K L+ + + HC +TD G + +
Sbjct: 279 TLLARNCHELEKMDLEECILITDSTLIQLSIHCPK-LQALSLSHCELITDDGILHLSNST 337
Query: 219 C--PQIRILLFHGCPLITDHSREVLEQLVGPNKLK 251
C ++R+L C LITD + E LE G +L+
Sbjct: 338 CGHERLRVLELDNCLLITDVALEHLENCRGLERLE 372
Score = 82.8 bits (203), Expect = 3e-16
Identities = 58/217 (26%), Positives = 107/217 (49%), Gaps = 28/217 (12%)
Query: 44 MSMQGQITDSNISEILHPEVQTLDLRSC-DISDAALLHLS-NCRKLKKLNLNA------- 94
+ ++G++ + NIS+ ++ L LR C + D++L + NCR ++ LNLN
Sbjct: 62 IDVEGRVVE-NISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDS 120
Query: 95 ---------------SKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALN 139
+ VS+T+ +K ++ C L +L C +T +G+ AL
Sbjct: 121 TCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRG 180
Query: 140 CQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEE 198
C+ LK + L GC + D +L + C L ++ S ++++D GV+ + G +L+
Sbjct: 181 CRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRG--CHRLQA 238
Query: 199 IHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
+ + C NLTD ++ A+ CP+++IL C +TD
Sbjct: 239 LCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTD 275
Score = 68.2 bits (165), Expect = 7e-12
Identities = 39/156 (25%), Positives = 79/156 (50%), Gaps = 8/156 (5%)
Query: 99 RVSVTSEGIKAVASSCS-YLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDV 157
++ V ++ ++ C +L + SL+ C + D + A NC+ ++ ++L GC ITD
Sbjct: 61 QIDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDS 120
Query: 158 SLHALGKNCPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVL 216
+ ++L + C L+ +D S +++S + + G + LE +++ C +T +EA++
Sbjct: 121 TCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEG--CRNLEYLNLSWCDQITKDGIEALV 178
Query: 217 TYCPQIRILLFHGCPLITD----HSREVLEQLVGPN 248
C ++ LL GC + D H + +LV N
Sbjct: 179 RGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLN 214
Score = 54.3 bits (129), Expect = 1e-07
Identities = 38/130 (29%), Positives = 72/130 (55%), Gaps = 11/130 (8%)
Query: 61 PEVQTLDLRSCD-ISDAALLHLS-NCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLH 118
P +Q L+ C ++DA L+ NC +L+K++L + +T + ++ C L
Sbjct: 260 PRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEEC----ILITDSTLIQLSIHCPKLQ 315
Query: 119 EASLKRCCNLTDEGVVALALNC---QLLKIIDLGGCLSITDVSLHALGKNCPFLQCVD-F 174
SL C +TD+G++ L+ + + L++++L CL ITDV+L L +NC L+ ++ +
Sbjct: 316 ALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHL-ENCRGLERLELY 374
Query: 175 SATQVSDSGV 184
QV+ +G+
Sbjct: 375 DCQQVTRAGI 384
Score = 34.3 bits (77), Expect = 0.11
Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 10/74 (13%)
Query: 50 ITDSNISEIL-----HPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVT 103
ITD I + H ++ L+L +C I+D AL HL NCR L++L L + VT
Sbjct: 325 ITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLELYDCQ----QVT 380
Query: 104 SEGIKAVASSCSYL 117
GIK + + ++
Sbjct: 381 RAGIKRMRAQLPHV 394
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 92.0 bits (227), Expect = 4e-19
Identities = 53/178 (29%), Positives = 92/178 (51%), Gaps = 9/178 (5%)
Query: 61 PEVQTLDLRSCD--ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLH 118
P ++ L++ CD D + C LK L L + E +K + + C L
Sbjct: 169 PLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGC----TQLEDEALKYIGAHCPELV 224
Query: 119 EASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-AT 177
+L+ C +TDEG++ + C L+ + GC +ITD L+ALG+NCP L+ ++ + +
Sbjct: 225 TLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCS 284
Query: 178 QVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
Q++D G L +LE++ + CV +TD + + +CP++++L C LITD
Sbjct: 285 QLTDVGFTTLARN--CHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITD 340
Score = 89.4 bits (220), Expect = 3e-18
Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 28/215 (13%)
Query: 46 MQGQITDSNISEILHPEVQTLDLRSC-DISDAALLHLS-NCRKLKKLNLNA--------- 94
++G++ + NIS+ ++ L LR C + D AL + NCR ++ LNLN
Sbjct: 77 IEGRVVE-NISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATC 135
Query: 95 -------------SKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQ 141
+ S+T+ +KA++ C L + ++ C +T +G+ AL C
Sbjct: 136 TSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCG 195
Query: 142 LLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIH 200
LK + L GC + D +L +G +CP L ++ + Q++D G+I + G KL+ +
Sbjct: 196 GLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRG--CHKLQSLC 253
Query: 201 MGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
C N+TD + A+ CP++RIL C +TD
Sbjct: 254 ASGCSNITDAILNALGQNCPRLRILEVARCSQLTD 288
Score = 64.3 bits (155), Expect = 1e-10
Identities = 34/133 (25%), Positives = 70/133 (52%), Gaps = 4/133 (3%)
Query: 107 IKAVASSCS-YLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
++ ++ C +L + SL+ C + D + A NC+ +++++L GC TD + +L K
Sbjct: 82 VENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKF 141
Query: 166 CPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRI 224
C L+ +D S T +++ + AL G LE++++ C +T ++A++ C ++
Sbjct: 142 CSKLRHLDLASCTSITNMSLKALSEG--CPLLEQLNISWCDQVTKDGIQALVRGCGGLKA 199
Query: 225 LLFHGCPLITDHS 237
L GC + D +
Sbjct: 200 LFLKGCTQLEDEA 212
Score = 61.2 bits (147), Expect = 8e-10
Identities = 48/184 (26%), Positives = 88/184 (47%), Gaps = 15/184 (8%)
Query: 49 QITDSNISEILHP--EVQTLDLRSC-DISDAALLHLS-NCRKLKKLNLNASKGNRVSVTS 104
QITD + I ++Q+L C +I+DA L L NC +L+ L + +T
Sbjct: 233 QITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCS----QLTD 288
Query: 105 EGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGK 164
G +A +C L + L+ C +TD ++ L+++C L+++ L C ITD + LG
Sbjct: 289 VGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGN 348
Query: 165 NC---PFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCP 220
L+ ++ + ++D+ + L S LE I + C +T ++ + T+ P
Sbjct: 349 GACAHDQLEVIELDNCPLITDASLEHLKS---CHSLERIELYDCQQITRAGIKRLRTHLP 405
Query: 221 QIRI 224
I++
Sbjct: 406 NIKV 409
Score = 33.9 bits (76), Expect = 0.14
Identities = 21/101 (20%), Positives = 39/101 (38%), Gaps = 27/101 (26%)
Query: 143 LKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMG 202
L+ + L GCL + D +L +NC + +E +++
Sbjct: 93 LRKLSLRGCLGVGDNALRTFAQNC---------------------------RNIEVLNLN 125
Query: 203 HCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVLEQ 243
C TD ++ +C ++R L C IT+ S + L +
Sbjct: 126 GCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSE 166
>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
sapiens]
Length = 303
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/174 (28%), Positives = 86/174 (49%), Gaps = 8/174 (4%)
Query: 69 RSCDISDAALLHL-SNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCN 127
R +SD +++ + S+C L+K+++ GN+ +T EG+K + S C L + +C
Sbjct: 23 RCKQLSDTSIIAVASHCPLLQKVHV----GNQDKLTDEGLKQLGSKCRELKDIHFGQCYK 78
Query: 128 LTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGVIAL 187
++DEG++ +A C L+ I + +TD S+ A ++CP LQ V F V+ GVI L
Sbjct: 79 ISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHL 138
Query: 188 VSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVL 241
+ L + + H L + V ++ C + L +I D EV+
Sbjct: 139 TK---LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVI 189
Score = 70.9 bits (172), Expect = 1e-12
Identities = 40/130 (30%), Positives = 70/130 (53%), Gaps = 3/130 (2%)
Query: 102 VTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHA 161
++ G+ +A C L + RC L+D ++A+A +C LL+ + +G +TD L
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60
Query: 162 LGKNCPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCP 220
LG C L+ + F ++SD G+I + G KL+ I+M +TD +V+A +CP
Sbjct: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKG--CLKLQRIYMQENKLVTDQSVKAFAEHCP 118
Query: 221 QIRILLFHGC 230
+++ + F GC
Sbjct: 119 ELQYVGFMGC 128
Score = 46.2 bits (108), Expect = 3e-05
Identities = 46/198 (23%), Positives = 79/198 (39%), Gaps = 38/198 (19%)
Query: 50 ITDSNISEILH--PEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGI 107
+TD ++ PE+Q + C ++ ++HL+ R L L+L + + +E +
Sbjct: 105 VTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLR----HITELDNETV 160
Query: 108 KAVASSCSYLHEASLKRCCN--LTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
+ C L +SL C N + D V +A Q LK + L C ITD +L A+G+
Sbjct: 161 MEIVKRCKNL--SSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGR- 216
Query: 166 CPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRIL 225
+S T +E + +G C +TD + +R L
Sbjct: 217 --------YSMT------------------IETVDVGWCKEITDQGATLIAQSSKSLRYL 250
Query: 226 LFHGCPLITDHSREVLEQ 243
C + + + E L Q
Sbjct: 251 GLMRCDKVNEVTVEQLVQ 268
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 71.2 bits (173), Expect = 8e-13
Identities = 69/265 (26%), Positives = 120/265 (45%), Gaps = 34/265 (12%)
Query: 10 LLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSM----------QGQITDSNISEI- 58
L D C+ ++ SR + + P+I D + +S ++TD++ I
Sbjct: 363 LTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFID 422
Query: 59 -LHPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVAS--SC 114
+P + + + C I+D++L LS ++L LNL N V + G+K +
Sbjct: 423 KNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNL----ANCVRIGDMGLKQFLDGPAS 478
Query: 115 SYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF 174
+ E +L C L+D V+ L+ C L + L C +T + + N L +D
Sbjct: 479 MRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDL 537
Query: 175 SATQVSDSGVIALVSGPCAKKLEEIHMGHC-------VNLTDGAVEAVLTYCPQIRILLF 227
S T +S+ G+ L KKL+E+ + C + +TD A+E + C + IL
Sbjct: 538 SGTDISNEGLNVLSRH---KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDI 594
Query: 228 HGCPLITDHSREVLEQL-VGPNKLK 251
GC L+TD ++LE L +G +L+
Sbjct: 595 SGCVLLTD---QILEDLQIGCKQLR 616
Score = 52.0 bits (123), Expect = 5e-07
Identities = 52/201 (25%), Positives = 89/201 (44%), Gaps = 13/201 (6%)
Query: 41 IKIMSMQGQITDSNISEILHP---EVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKG 97
I S++ I D I L V L+ R C + +S+CR L++LN++
Sbjct: 198 IDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVS---- 253
Query: 98 NRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDV 157
+ + T E ++ ++ C + +L +T+ + L + L+ + L C TD
Sbjct: 254 DCPTFTDESMRHISEGCPGVLCLNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDK 312
Query: 158 SLH--ALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEA 214
L LG C L +D S TQ+S G ++ C + + + LTD V+A
Sbjct: 313 GLQYLNLGNGCHKLIYLDLSGCTQISVQG-FRYIANSCT-GIMHLTINDMPTLTDNCVKA 370
Query: 215 VLTYCPQIRILLFHGCPLITD 235
++ C +I L+F G P I+D
Sbjct: 371 LVEKCSRITSLVFTGAPHISD 391
Score = 51.2 bits (121), Expect = 9e-07
Identities = 45/196 (22%), Positives = 80/196 (40%), Gaps = 32/196 (16%)
Query: 66 LDLRSC-DISDAALLHLSN-CRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLK 123
LDL C IS +++N C + L +N + ++T +KA+ CS +
Sbjct: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTIN----DMPTLTDNCVKALVEKCSRITSLVFT 384
Query: 124 RCCNLTDEGVVALALNCQLLKI-------------------------IDLGGCLSITDVS 158
+++D AL+ C+L KI I + C ITD S
Sbjct: 385 GAPHISDCTFRALSA-CKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSS 443
Query: 159 LHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTY 218
L +L + ++ D G+ + GP + ++ E+++ +CV L+D +V +
Sbjct: 444 LRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSER 503
Query: 219 CPQIRILLFHGCPLIT 234
CP + L C +T
Sbjct: 504 CPNLNYLSLRNCEHLT 519
Score = 51.2 bits (121), Expect = 9e-07
Identities = 27/94 (28%), Positives = 53/94 (56%), Gaps = 3/94 (3%)
Query: 65 TLDLRSCDISDAALLHLSNCRKLKKLNLNAS---KGNRVSVTSEGIKAVASSCSYLHEAS 121
++DL DIS+ L LS +KLK+L+++ + + +T ++ +++ C YLH
Sbjct: 534 SIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILD 593
Query: 122 LKRCCNLTDEGVVALALNCQLLKIIDLGGCLSIT 155
+ C LTD+ + L + C+ L+I+ + C +I+
Sbjct: 594 ISGCVLLTDQILEDLQIGCKQLRILKMQYCTNIS 627
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 69.3 bits (168), Expect = 3e-12
Identities = 59/228 (25%), Positives = 105/228 (46%), Gaps = 37/228 (16%)
Query: 49 QITDSNISEILH--PEVQTLDLRSC-DISDAAL------------LHLSNCRKLK----- 88
++TD + I PE++ L++ C +IS+ A+ L +S C K+
Sbjct: 198 RLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLT 257
Query: 89 ---KLNLNASKGNRVSVT-----------SEGIKAVASSCSYLHEASLKRCCNLTDEGVV 134
+ L+ G ++S+ EG+ +A+ C+ L L+RC LTDEG+
Sbjct: 258 REASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLR 317
Query: 135 ALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCA 193
L + C +K + + C ++D L + K L+ + + +V+D G I V+ C+
Sbjct: 318 YLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVG-IRYVAKYCS 376
Query: 194 KKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVL 241
KL ++ C +TD VE + C +++ L CPL++D E L
Sbjct: 377 -KLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECL 423
Score = 62.4 bits (150), Expect = 4e-10
Identities = 40/135 (29%), Positives = 70/135 (51%), Gaps = 8/135 (5%)
Query: 50 ITDSNISEI--LHPEVQTLDLRSCD-ISDAALLHLSN-CRKLKKLNLNASKGNRVSVTSE 105
++D + EI L ++ L + C ++D + +++ C KL+ LN +G +T
Sbjct: 337 VSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEG----ITDH 392
Query: 106 GIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
G++ +A +C+ L + +C ++D G+ LALNC LK + L C SIT L + N
Sbjct: 393 GVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAAN 452
Query: 166 CPFLQCVDFSATQVS 180
C LQ ++ +VS
Sbjct: 453 CFDLQTLNVQDCEVS 467
Score = 58.5 bits (140), Expect = 5e-09
Identities = 39/147 (26%), Positives = 67/147 (45%), Gaps = 6/147 (4%)
Query: 49 QITDSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNA---SKGNRVSVTSE 105
++TD + ++ + ++ +SD + R++ KL S + VT
Sbjct: 310 RLTDEGLRYLV---IYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDV 366
Query: 106 GIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
GI+ VA CS L + + C +TD GV LA NC LK +D+G C ++D L L N
Sbjct: 367 GIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALN 426
Query: 166 CPFLQCVDFSATQVSDSGVIALVSGPC 192
C L+ + + + + +V+ C
Sbjct: 427 CFNLKRLSLKSCESITGQGLQIVAANC 453
Score = 56.6 bits (135), Expect = 2e-08
Identities = 36/151 (23%), Positives = 69/151 (45%), Gaps = 9/151 (5%)
Query: 102 VTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSL-- 159
+T G+ +A C L + C N+++E V + C L+ +D+ GC +T +SL
Sbjct: 199 LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTR 258
Query: 160 HALGKNCPF------LQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVE 213
A K P ++ +D + V + + ++ C + L +++ CV LTD +
Sbjct: 259 EASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQ-LTHLYLRRCVRLTDEGLR 317
Query: 214 AVLTYCPQIRILLFHGCPLITDHSREVLEQL 244
++ YC I+ L C ++D + +L
Sbjct: 318 YLVIYCASIKELSVSDCRFVSDFGLREIAKL 348
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 7/135 (5%)
Query: 114 CSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVD 173
C L ++ C LTD G+ +A C L+ +++ GC +I++ ++ + CP L+ +D
Sbjct: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
Query: 174 FS----ATQVSDSGVIALVSGPCAKK---LEEIHMGHCVNLTDGAVEAVLTYCPQIRILL 226
S T +S + ++ P K + + M C L D + + +C Q+ L
Sbjct: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304
Query: 227 FHGCPLITDHSREVL 241
C +TD L
Sbjct: 305 LRRCVRLTDEGLRYL 319
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 68.6 bits (166), Expect = 5e-12
Identities = 43/149 (28%), Positives = 74/149 (49%), Gaps = 5/149 (3%)
Query: 65 TLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKR 124
++DL DIS+ L LS +KLK+L+++ +T +GI+A S L +
Sbjct: 534 SIDLSGTDISNEGLNVLSRHKKLKELSVSEC----YRITDDGIQAFCKSSLILEHLDVSY 589
Query: 125 CCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGV 184
C L+D + ALA+ C L + + GC ITD ++ L C +L +D S + +
Sbjct: 590 CSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQI 649
Query: 185 IALVSGPCAKKLEEIHMGHCVNLTDGAVE 213
+ + C K+L + M +C N++ A +
Sbjct: 650 LEDLQIGC-KQLRILKMQYCTNISKKAAQ 677
Score = 67.4 bits (163), Expect = 1e-11
Identities = 65/270 (24%), Positives = 113/270 (41%), Gaps = 43/270 (15%)
Query: 10 LLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSM----------QGQITDSNISEI- 58
L D C+ ++ SR + + P+I D + +S ++TD++ I
Sbjct: 363 LTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFID 422
Query: 59 -LHPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVAS--SC 114
+P + + + C I+D++L LS ++L LNL N V + G+K +
Sbjct: 423 KNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNL----ANCVRIGDMGLKQFLDGPAS 478
Query: 115 SYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF 174
+ E +L C L+D V+ L+ C L + L C +T + + N L +D
Sbjct: 479 MRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDL 537
Query: 175 SATQVSDSGVIALVSGPCAKKL-----------------------EEIHMGHCVNLTDGA 211
S T +S+ G+ L K+L E + + +C L+D
Sbjct: 538 SGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMI 597
Query: 212 VEAVLTYCPQIRILLFHGCPLITDHSREVL 241
++A+ YC + L GCP ITD + E+L
Sbjct: 598 IKALAIYCINLTSLSIAGCPKITDSAMEML 627
Score = 52.0 bits (123), Expect = 5e-07
Identities = 52/201 (25%), Positives = 89/201 (44%), Gaps = 13/201 (6%)
Query: 41 IKIMSMQGQITDSNISEILHP---EVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKG 97
I S++ I D I L V L+ R C + +S+CR L++LN++
Sbjct: 198 IDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVS---- 253
Query: 98 NRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDV 157
+ + T E ++ ++ C + +L +T+ + L + L+ + L C TD
Sbjct: 254 DCPTFTDESMRHISEGCPGVLCLNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDK 312
Query: 158 SLH--ALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEA 214
L LG C L +D S TQ+S G ++ C + + + LTD V+A
Sbjct: 313 GLQYLNLGNGCHKLIYLDLSGCTQISVQG-FRYIANSCT-GIMHLTINDMPTLTDNCVKA 370
Query: 215 VLTYCPQIRILLFHGCPLITD 235
++ C +I L+F G P I+D
Sbjct: 371 LVEKCSRITSLVFTGAPHISD 391
Score = 51.2 bits (121), Expect = 9e-07
Identities = 45/196 (22%), Positives = 80/196 (40%), Gaps = 32/196 (16%)
Query: 66 LDLRSC-DISDAALLHLSN-CRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLK 123
LDL C IS +++N C + L +N + ++T +KA+ CS +
Sbjct: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTIN----DMPTLTDNCVKALVEKCSRITSLVFT 384
Query: 124 RCCNLTDEGVVALALNCQLLKI-------------------------IDLGGCLSITDVS 158
+++D AL+ C+L KI I + C ITD S
Sbjct: 385 GAPHISDCTFRALSA-CKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSS 443
Query: 159 LHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTY 218
L +L + ++ D G+ + GP + ++ E+++ +CV L+D +V +
Sbjct: 444 LRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSER 503
Query: 219 CPQIRILLFHGCPLIT 234
CP + L C +T
Sbjct: 504 CPNLNYLSLRNCEHLT 519
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 66.2 bits (160), Expect = 3e-11
Identities = 48/184 (26%), Positives = 91/184 (49%), Gaps = 9/184 (4%)
Query: 63 VQTLDLRSCD-ISDAALLHLSN-CRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEA 120
++ L L+ C ++D +L H+S L+ LNL+ G ++ G+ ++ S L
Sbjct: 204 LEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGG----ISDAGLLHLSHMGS-LRSL 258
Query: 121 SLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVS 180
+L+ C N++D G++ LA+ L +D+ C + D SL + + L+ + + +S
Sbjct: 259 NLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHIS 318
Query: 181 DSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREV 240
D G+ +V L +++G CV +TD +E + + Q+ + +GC IT E
Sbjct: 319 DDGINRMVRQ--MHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER 376
Query: 241 LEQL 244
+ QL
Sbjct: 377 ITQL 380
Score = 45.1 bits (105), Expect = 6e-05
Identities = 41/176 (23%), Positives = 77/176 (43%), Gaps = 27/176 (15%)
Query: 63 VQTLDLRSC-DISDAALLH--LSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHE 119
+++L+L C +++D L H + L+ LNL+ K +T + +A L
Sbjct: 92 IESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCK----QITDSSLGRIAQYLKGLEV 147
Query: 120 ASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQV 179
L C N+T+ G++ +A Q LK ++L C ++DV + L T+
Sbjct: 148 LELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLA-----------GMTRS 196
Query: 180 SDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
+ G + LE++ + C LTD +++ + +R+L C I+D
Sbjct: 197 AAEGCLG---------LEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 57.0 bits (136), Expect = 2e-08
Identities = 51/191 (26%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 55 ISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSC 114
IS++L P + L L++ ++D AL + + + L + +T+ G+ V S
Sbjct: 263 ISQLL-PNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLL--SCWEITNHGVVNVVHSL 319
Query: 115 SYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFL-QCVD 173
L SL C +TD+GV +A N + L+ +DL C ITD++L + + L + V
Sbjct: 320 PNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVL 379
Query: 174 FSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLI 233
+++D+G+ L + L +++ C + D ++ +L +R+L GCPL+
Sbjct: 380 DRCVRITDTGLSYLST---MSSLRSLYLRWCCQVQDFGLKHLLA-LGSLRLLSPAGCPLL 435
Query: 234 TDHSREVLEQL 244
T L QL
Sbjct: 436 TTTGLSGLVQL 446
Score = 45.8 bits (107), Expect = 4e-05
Identities = 34/183 (18%), Positives = 80/183 (43%), Gaps = 3/183 (1%)
Query: 73 ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEG 132
+SD + + L K + A R ++T G++ + + L C + T+ G
Sbjct: 176 VSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAG 235
Query: 133 VVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGVIALVSGPC 192
+ + +L+ ++ + + C+++ D ++ A+ + P L + A V+D+ +A +
Sbjct: 236 LWS-SLSARITSL-SVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTA-LAYFTARQ 292
Query: 193 AKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVLEQLVGPNKLKQ 252
+ + C +T+ V V+ P + L GC +TD E++ + + +
Sbjct: 293 GHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLD 352
Query: 253 VTW 255
++W
Sbjct: 353 LSW 355
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 54.3 bits (129), Expect = 1e-07
Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 5/112 (4%)
Query: 63 VQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEAS 121
+Q LDL +C ++DA+L + +L++L+L+ +T G+ AVA C L +
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQLRQLSLSLLP----ELTDNGLVAVARGCPSLEHLA 132
Query: 122 LKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVD 173
L C L+D+G A + L+ ++L C + + +L A+G+ C L+ +D
Sbjct: 133 LSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLD 184
Score = 47.4 bits (111), Expect = 1e-05
Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 74 SDAALLHLSNCRKLK---KLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTD 130
S A L L++C LK +L AS +G + L E L C LTD
Sbjct: 33 SQLASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRA--LQELDLTACSKLTD 90
Query: 131 EGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-ATQVSDSGVIALVS 189
+ A L L+ + L +TD L A+ + CP L+ + S +++SD G S
Sbjct: 91 ASL-AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAAS 149
Query: 190 GPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCP 231
+L+ +++ C L + ++A+ C Q+R+L CP
Sbjct: 150 S--WPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCP 189
Score = 41.6 bits (96), Expect = 7e-04
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 138 LNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSAT---QVSDSGVIALVSGPCAK 194
L + L+ +DL C +TD SL K FLQ S + +++D+G++A+ G
Sbjct: 72 LTLRALQELDLTACSKLTDASL---AKVLQFLQLRQLSLSLLPELTDNGLVAVARG--CP 126
Query: 195 KLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVLEQ 243
LE + + HC L+D + P+++ L C + + + + + Q
Sbjct: 127 SLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQ 175
Score = 40.0 bits (92), Expect = 0.002
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 8/143 (5%)
Query: 81 LSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNC 140
L R L++L+L A S ++ A L + SL LTD G+VA+A C
Sbjct: 71 LLTLRALQELDLTAC-----SKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGC 125
Query: 141 QLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSA-TQVSDSGVIALVSGPCAKKLEEI 199
L+ + L C ++D + P LQ ++ S+ +Q+ + + A+ G ++L +
Sbjct: 126 PSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAI--GQACRQLRVL 183
Query: 200 HMGHCVNLTDGAVEAVLTYCPQI 222
+ C + AV PQ+
Sbjct: 184 DVATCPGINMAAVRRFQAQLPQV 206
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 54.3 bits (129), Expect = 1e-07
Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 5/112 (4%)
Query: 63 VQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEAS 121
+Q LDL +C ++DA+L + +L++L+L+ +T G+ AVA C L +
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQLRQLSLSLLP----ELTDNGLVAVARGCPSLEHLA 132
Query: 122 LKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVD 173
L C L+D+G A + L+ ++L C + + +L A+G+ C L+ +D
Sbjct: 133 LSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLD 184
Score = 47.4 bits (111), Expect = 1e-05
Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 74 SDAALLHLSNCRKLK---KLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTD 130
S A L L++C LK +L AS +G + L E L C LTD
Sbjct: 33 SQLASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRA--LQELDLTACSKLTD 90
Query: 131 EGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-ATQVSDSGVIALVS 189
+ A L L+ + L +TD L A+ + CP L+ + S +++SD G S
Sbjct: 91 ASL-AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAAS 149
Query: 190 GPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCP 231
+L+ +++ C L + ++A+ C Q+R+L CP
Sbjct: 150 S--WPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCP 189
Score = 41.6 bits (96), Expect = 7e-04
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 138 LNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSAT---QVSDSGVIALVSGPCAK 194
L + L+ +DL C +TD SL K FLQ S + +++D+G++A+ G
Sbjct: 72 LTLRALQELDLTACSKLTDASL---AKVLQFLQLRQLSLSLLPELTDNGLVAVARG--CP 126
Query: 195 KLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVLEQ 243
LE + + HC L+D + P+++ L C + + + + + Q
Sbjct: 127 SLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQ 175
Score = 40.0 bits (92), Expect = 0.002
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 8/143 (5%)
Query: 81 LSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNC 140
L R L++L+L A S ++ A L + SL LTD G+VA+A C
Sbjct: 71 LLTLRALQELDLTAC-----SKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGC 125
Query: 141 QLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSA-TQVSDSGVIALVSGPCAKKLEEI 199
L+ + L C ++D + P LQ ++ S+ +Q+ + + A+ G ++L +
Sbjct: 126 PSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAI--GQACRQLRVL 183
Query: 200 HMGHCVNLTDGAVEAVLTYCPQI 222
+ C + AV PQ+
Sbjct: 184 DVATCPGINMAAVRRFQAQLPQV 206
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 53.1 bits (126), Expect = 2e-07
Identities = 55/222 (24%), Positives = 86/222 (38%), Gaps = 54/222 (24%)
Query: 55 ISEILHPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTS--------- 104
ISE+ P +Q L+L SCD + A H++ LK+L L +K + ++ S
Sbjct: 396 ISEMC-PNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQ 454
Query: 105 ----------EGIKAVAS----SCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGG 150
E +AS C L L RC N+T+ G+ LA C LL+ +DLG
Sbjct: 455 HLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGW 514
Query: 151 C----------------------------LSITDVSLHALGKNCPFLQCVDFSATQVSDS 182
C S+ D + L NC LQ +D T++
Sbjct: 515 CPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSP 574
Query: 183 GVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRI 224
+ + C K L + + C + + AV + P++ I
Sbjct: 575 ASLRKLLESC-KDLSLLDVSFCSQIDNRAVLELNASFPKVFI 615
Score = 29.6 bits (65), Expect = 2.7
Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 50 ITDSNISEILH--PEVQTLDLRSCDI---SDAALLHLSN-CRKLKKLNLNASKGNRVSVT 103
IT++ I+E+ P ++ LDL C S L++ L+KL L A++ SV
Sbjct: 492 ITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANR----SVC 547
Query: 104 SEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALG 163
I +A +C+ L + + ++ + L +C+ L ++D+ C I + ++ L
Sbjct: 548 DTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELN 607
Query: 164 KNCP 167
+ P
Sbjct: 608 ASFP 611
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 48.5 bits (114), Expect = 6e-06
Identities = 34/130 (26%), Positives = 59/130 (45%), Gaps = 2/130 (1%)
Query: 102 VTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHA 161
++ E + V + L +L C L+ + ALA C L+ + L C + ++L
Sbjct: 101 LSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG 160
Query: 162 LGKNCPFLQCVDFSA-TQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCP 220
L CP L+ +D +A Q+ D ++ L A L + + N+ D AV+ + CP
Sbjct: 161 LADRCPALEELDLTACRQLKDEAIVYLAQRRGA-GLRSLSLAVNANVGDAAVQELARNCP 219
Query: 221 QIRILLFHGC 230
++ L GC
Sbjct: 220 ELHHLDLTGC 229
Score = 45.8 bits (107), Expect = 4e-05
Identities = 36/113 (31%), Positives = 49/113 (43%), Gaps = 7/113 (6%)
Query: 61 PEVQTLDLRSCDISDAALLH--LSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSY-L 117
P +Q L L CD D L C L++L+L A + + E I +A L
Sbjct: 140 PRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACR----QLKDEAIVYLAQRRGAGL 195
Query: 118 HEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQ 170
SL N+ D V LA NC L +DL GCL + + L + CP L+
Sbjct: 196 RSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLR 248
Score = 44.7 bits (104), Expect = 8e-05
Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 61 PEVQTLDLRSC-DISDAALLHLSNCRK--LKKLNLNASKGNRVSVTSEGIKAVASSCSYL 117
P ++ LDL +C + D A+++L+ R L+ L+L + +V ++ +A +C L
Sbjct: 166 PALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVN----ANVGDAAVQELARNCPEL 221
Query: 118 HEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGK 164
H L C + +GV LA C +L+ + + C + + SL L K
Sbjct: 222 HHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRK 268
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 42.7 bits (99), Expect = 3e-04
Identities = 46/205 (22%), Positives = 94/205 (45%), Gaps = 27/205 (13%)
Query: 35 NIKDRLIKIMSMQGQITDSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNA 94
++ + +I++ ++ G ++ + ++Q L L +SD + L+ L +LNL+
Sbjct: 187 DLSNSVIEVSTLHGILSQCS-------KLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSG 239
Query: 95 SKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGV-VALALNCQLLKIIDLGGC-L 152
G + ++ + SSCS L E +L C + T++ V VA+A + + ++L G
Sbjct: 240 CSG----FSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRK 295
Query: 153 SITDVSLHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKK------LEEIHMGHCVN 206
++ L L + CP L +D +SDS ++ C ++ L+ + + C +
Sbjct: 296 NLQKSDLSTLVRRCPNLVHLD-----LSDS---VMLKNDCFQEFFQLNYLQHLSLSRCYD 347
Query: 207 LTDGAVEAVLTYCPQIRILLFHGCP 231
+ + V +IR+ GCP
Sbjct: 348 IIPETLLLVTRAGVRIRLDSDIGCP 372
>gi|169160755 PREDICTED: zyg-11 homolog A (C. elegans) [Homo
sapiens]
Length = 736
Score = 41.2 bits (95), Expect = 0.001
Identities = 54/228 (23%), Positives = 103/228 (45%), Gaps = 34/228 (14%)
Query: 10 LLDLCLWCFMKNISRYLTDIKP-----------LPPNIKDRLIKIMSMQGQITD--SNIS 56
L+++CL + N+ + ++ +P P + DR +++M+ QG++TD ++I
Sbjct: 38 LVNICLNVLIANLEKLCSE-RPDGTLCLPEHWSFPQEVADRFLRVMTWQGKLTDRTASIF 96
Query: 57 EILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSY 116
+++ ++++ IS AA + KL +LN A V ++ CS
Sbjct: 97 RGNQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATA-----VHADLPVPDIISGLCSN 151
Query: 117 LHEASLKRCCNLTDEGVVALALNCQLLKIIDLGG--CLSITDVSLH----ALGKNCPFLQ 170
+C L ++ N +LL L G LS+ +V H A P L+
Sbjct: 152 RWIQQNLQCLLLDS---TSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLE 208
Query: 171 CVDFSATQVSDSGVIALVSGPCAKKLEEIHMGH--CVNLTDGAVEAVL 216
+D S T V+D + AL++ C +L+ + M + C+ +T + AV+
Sbjct: 209 SLDISNTLVTD--ISALLT--CKDRLKSLTMHYLKCLAMTKSQILAVI 252
>gi|88948888 PREDICTED: zyg-11 homolog A (C. elegans) [Homo sapiens]
Length = 736
Score = 41.2 bits (95), Expect = 0.001
Identities = 54/228 (23%), Positives = 103/228 (45%), Gaps = 34/228 (14%)
Query: 10 LLDLCLWCFMKNISRYLTDIKP-----------LPPNIKDRLIKIMSMQGQITD--SNIS 56
L+++CL + N+ + ++ +P P + DR +++M+ QG++TD ++I
Sbjct: 38 LVNICLNVLIANLEKLCSE-RPDGTLCLPEHWSFPQEVADRFLRVMTWQGKLTDRTASIF 96
Query: 57 EILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSY 116
+++ ++++ IS AA + KL +LN A V ++ CS
Sbjct: 97 RGNQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATA-----VHADLPVPDIISGLCSN 151
Query: 117 LHEASLKRCCNLTDEGVVALALNCQLLKIIDLGG--CLSITDVSLH----ALGKNCPFLQ 170
+C L ++ N +LL L G LS+ +V H A P L+
Sbjct: 152 RWIQQNLQCLLLDS---TSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLE 208
Query: 171 CVDFSATQVSDSGVIALVSGPCAKKLEEIHMGH--CVNLTDGAVEAVL 216
+D S T V+D + AL++ C +L+ + M + C+ +T + AV+
Sbjct: 209 SLDISNTLVTD--ISALLT--CKDRLKSLTMHYLKCLAMTKSQILAVI 252
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 40.8 bits (94), Expect = 0.001
Identities = 35/143 (24%), Positives = 70/143 (48%), Gaps = 13/143 (9%)
Query: 35 NIKDRLIKIMSMQGQITDSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNA 94
++ + +I++ ++ G ++ + ++Q L L +SD + L+ L +LNL+
Sbjct: 187 DLSNSVIEVSTLHGILSQCS-------KLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSG 239
Query: 95 SKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGV-VALALNCQLLKIIDLGGC-L 152
G + ++ + SSCS L E +L C + T++ V VA+A + + ++L G
Sbjct: 240 CSG----FSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRK 295
Query: 153 SITDVSLHALGKNCPFLQCVDFS 175
++ L L + CP L +D S
Sbjct: 296 NLQKSDLSTLVRRCPNLVHLDLS 318
>gi|113408672 PREDICTED: zyg-11 homolog A [Homo sapiens]
Length = 759
Score = 39.7 bits (91), Expect = 0.003
Identities = 53/228 (23%), Positives = 103/228 (45%), Gaps = 34/228 (14%)
Query: 10 LLDLCLWCFMKNISRYLTDIKP-----------LPPNIKDRLIKIMSMQGQITD--SNIS 56
L+++CL + N+ + ++ +P P + +R +++M+ QG++TD ++I
Sbjct: 38 LVNICLNVLIANLEKLCSE-RPDGTLCLPEHWSFPQEVAERFLRVMTWQGKLTDRTASIF 96
Query: 57 EILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSY 116
+++ ++++ IS AA + KL +LN A V ++ CS
Sbjct: 97 RGNQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATA-----VHADLPVPDIISGLCSN 151
Query: 117 LHEASLKRCCNLTDEGVVALALNCQLLKIIDLGG--CLSITDVSLH----ALGKNCPFLQ 170
+C L ++ N +LL L G LS+ +V H A P L+
Sbjct: 152 RWIQQNLQCLLLDS---TSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLE 208
Query: 171 CVDFSATQVSDSGVIALVSGPCAKKLEEIHMGH--CVNLTDGAVEAVL 216
+D S T V+D + AL++ C +L+ + M + C+ +T + AV+
Sbjct: 209 SLDISNTLVTD--ISALLT--CKDRLKSLTMHYLKCLAMTKSQILAVI 252
>gi|226437632 zyg-11 homolog A [Homo sapiens]
Length = 759
Score = 39.7 bits (91), Expect = 0.003
Identities = 53/228 (23%), Positives = 103/228 (45%), Gaps = 34/228 (14%)
Query: 10 LLDLCLWCFMKNISRYLTDIKP-----------LPPNIKDRLIKIMSMQGQITD--SNIS 56
L+++CL + N+ + ++ +P P + +R +++M+ QG++TD ++I
Sbjct: 38 LVNICLNVLIANLEKLCSE-RPDGTLCLPEHWSFPQEVAERFLRVMTWQGKLTDRTASIF 96
Query: 57 EILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSY 116
+++ ++++ IS AA + KL +LN A V ++ CS
Sbjct: 97 RGNQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATA-----VHADLPVPDIISGLCSN 151
Query: 117 LHEASLKRCCNLTDEGVVALALNCQLLKIIDLGG--CLSITDVSLH----ALGKNCPFLQ 170
+C L ++ N +LL L G LS+ +V H A P L+
Sbjct: 152 RWIQQNLQCLLLDS---TSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLE 208
Query: 171 CVDFSATQVSDSGVIALVSGPCAKKLEEIHMGH--CVNLTDGAVEAVL 216
+D S T V+D + AL++ C +L+ + M + C+ +T + AV+
Sbjct: 209 SLDISNTLVTD--ISALLT--CKDRLKSLTMHYLKCLAMTKSQILAVI 252
>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
sapiens]
Length = 565
Score = 35.4 bits (80), Expect = 0.050
Identities = 21/51 (41%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 121 SLKRCCNLTDEGVVALALNCQL--LKIIDLGGCLSITDVSLHALGKNCPFL 169
SL C +TD G+ L L L L+ ++L GCL+IT L L CP L
Sbjct: 478 SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSL 528
Score = 32.7 bits (73), Expect = 0.32
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 166 CPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAV 215
CP L+ +D + T +SDS + C + L + + C +TD A+E +
Sbjct: 229 CPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKI 278
Score = 32.3 bits (72), Expect = 0.42
Identities = 13/53 (24%), Positives = 28/53 (52%)
Query: 178 QVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGC 230
Q++D G+ L G LE +++ C+ +T ++ +++ CP + F+ C
Sbjct: 484 QITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
Score = 30.0 bits (66), Expect = 2.1
Identities = 12/25 (48%), Positives = 17/25 (68%)
Query: 140 CQLLKIIDLGGCLSITDVSLHALGK 164
CQ L+ +DL GC ITDV+L + +
Sbjct: 256 CQSLRHLDLSGCEKITDVALEKISR 280
Score = 28.1 bits (61), Expect = 7.9
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 141 QLLKIIDLGGCLSITDVSLH--ALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLE 197
++L + L GC ITD L LG P+L+ ++ S ++ +G+ LVS L
Sbjct: 472 RVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS--ACPSLN 529
Query: 198 EIHMGHCVNL 207
+ + +C N+
Sbjct: 530 DEYFYYCDNI 539
>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
sapiens]
Length = 691
Score = 35.4 bits (80), Expect = 0.050
Identities = 21/51 (41%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 121 SLKRCCNLTDEGVVALALNCQL--LKIIDLGGCLSITDVSLHALGKNCPFL 169
SL C +TD G+ L L L L+ ++L GCL+IT L L CP L
Sbjct: 604 SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSL 654
Score = 32.7 bits (73), Expect = 0.32
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 166 CPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAV 215
CP L+ +D + T +SDS + C + L + + C +TD A+E +
Sbjct: 355 CPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKI 404
Score = 32.3 bits (72), Expect = 0.42
Identities = 13/53 (24%), Positives = 28/53 (52%)
Query: 178 QVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGC 230
Q++D G+ L G LE +++ C+ +T ++ +++ CP + F+ C
Sbjct: 610 QITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 662
Score = 30.0 bits (66), Expect = 2.1
Identities = 12/25 (48%), Positives = 17/25 (68%)
Query: 140 CQLLKIIDLGGCLSITDVSLHALGK 164
CQ L+ +DL GC ITDV+L + +
Sbjct: 382 CQSLRHLDLSGCEKITDVALEKISR 406
Score = 28.1 bits (61), Expect = 7.9
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 141 QLLKIIDLGGCLSITDVSLH--ALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLE 197
++L + L GC ITD L LG P+L+ ++ S ++ +G+ LVS L
Sbjct: 598 RVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS--ACPSLN 655
Query: 198 EIHMGHCVNL 207
+ + +C N+
Sbjct: 656 DEYFYYCDNI 665
>gi|46249373 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 35.0 bits (79), Expect = 0.065
Identities = 24/110 (21%), Positives = 57/110 (51%), Gaps = 10/110 (9%)
Query: 52 DSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVS-VTSEGIKAV 110
D + +++P ++TL + +C +S+ ++HLS + +L++ + G ++ V+ E ++A+
Sbjct: 314 DQLLRHVMNP-LETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQAL 372
Query: 111 ASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLH 160
S + + C +TD+ ++AL + L C +T +S +
Sbjct: 373 LERASATLQDLVFDECGITDDQLLAL--------LPSLSHCSQLTTLSFY 414
Score = 29.3 bits (64), Expect = 3.6
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 177 TQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVL---TYCPQIRILLFHGCPLI 233
T VS + AL+ A L+++ C +TD + A+L ++C Q+ L F+G +
Sbjct: 362 TDVSPEPLQALLERASAT-LQDLVFDEC-GITDDQLLALLPSLSHCSQLTTLSFYGNSIS 419
Query: 234 TDHSREVLEQLVGPNKLKQVTWTV 257
+ +L+ L+G + L V + V
Sbjct: 420 ISALQSLLQHLIGLSNLTHVLYPV 443
>gi|46249371 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 35.0 bits (79), Expect = 0.065
Identities = 24/110 (21%), Positives = 57/110 (51%), Gaps = 10/110 (9%)
Query: 52 DSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVS-VTSEGIKAV 110
D + +++P ++TL + +C +S+ ++HLS + +L++ + G ++ V+ E ++A+
Sbjct: 314 DQLLRHVMNP-LETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQAL 372
Query: 111 ASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLH 160
S + + C +TD+ ++AL + L C +T +S +
Sbjct: 373 LERASATLQDLVFDECGITDDQLLAL--------LPSLSHCSQLTTLSFY 414
Score = 29.3 bits (64), Expect = 3.6
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 177 TQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVL---TYCPQIRILLFHGCPLI 233
T VS + AL+ A L+++ C +TD + A+L ++C Q+ L F+G +
Sbjct: 362 TDVSPEPLQALLERASAT-LQDLVFDEC-GITDDQLLALLPSLSHCSQLTTLSFYGNSIS 419
Query: 234 TDHSREVLEQLVGPNKLKQVTWTV 257
+ +L+ L+G + L V + V
Sbjct: 420 ISALQSLLQHLIGLSNLTHVLYPV 443
>gi|46249369 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 35.0 bits (79), Expect = 0.065
Identities = 24/110 (21%), Positives = 57/110 (51%), Gaps = 10/110 (9%)
Query: 52 DSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVS-VTSEGIKAV 110
D + +++P ++TL + +C +S+ ++HLS + +L++ + G ++ V+ E ++A+
Sbjct: 314 DQLLRHVMNP-LETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQAL 372
Query: 111 ASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLH 160
S + + C +TD+ ++AL + L C +T +S +
Sbjct: 373 LERASATLQDLVFDECGITDDQLLAL--------LPSLSHCSQLTTLSFY 414
Score = 29.3 bits (64), Expect = 3.6
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 177 TQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVL---TYCPQIRILLFHGCPLI 233
T VS + AL+ A L+++ C +TD + A+L ++C Q+ L F+G +
Sbjct: 362 TDVSPEPLQALLERASAT-LQDLVFDEC-GITDDQLLALLPSLSHCSQLTTLSFYGNSIS 419
Query: 234 TDHSREVLEQLVGPNKLKQVTWTV 257
+ +L+ L+G + L V + V
Sbjct: 420 ISALQSLLQHLIGLSNLTHVLYPV 443
>gi|46249367 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 35.0 bits (79), Expect = 0.065
Identities = 24/110 (21%), Positives = 57/110 (51%), Gaps = 10/110 (9%)
Query: 52 DSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVS-VTSEGIKAV 110
D + +++P ++TL + +C +S+ ++HLS + +L++ + G ++ V+ E ++A+
Sbjct: 314 DQLLRHVMNP-LETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQAL 372
Query: 111 ASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLH 160
S + + C +TD+ ++AL + L C +T +S +
Sbjct: 373 LERASATLQDLVFDECGITDDQLLAL--------LPSLSHCSQLTTLSFY 414
Score = 29.3 bits (64), Expect = 3.6
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 177 TQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVL---TYCPQIRILLFHGCPLI 233
T VS + AL+ A L+++ C +TD + A+L ++C Q+ L F+G +
Sbjct: 362 TDVSPEPLQALLERASAT-LQDLVFDEC-GITDDQLLALLPSLSHCSQLTTLSFYGNSIS 419
Query: 234 TDHSREVLEQLVGPNKLKQVTWTV 257
+ +L+ L+G + L V + V
Sbjct: 420 ISALQSLLQHLIGLSNLTHVLYPV 443
>gi|5174641 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 35.0 bits (79), Expect = 0.065
Identities = 24/110 (21%), Positives = 57/110 (51%), Gaps = 10/110 (9%)
Query: 52 DSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVS-VTSEGIKAV 110
D + +++P ++TL + +C +S+ ++HLS + +L++ + G ++ V+ E ++A+
Sbjct: 314 DQLLRHVMNP-LETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQAL 372
Query: 111 ASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLH 160
S + + C +TD+ ++AL + L C +T +S +
Sbjct: 373 LERASATLQDLVFDECGITDDQLLAL--------LPSLSHCSQLTTLSFY 414
Score = 29.3 bits (64), Expect = 3.6
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 177 TQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVL---TYCPQIRILLFHGCPLI 233
T VS + AL+ A L+++ C +TD + A+L ++C Q+ L F+G +
Sbjct: 362 TDVSPEPLQALLERASAT-LQDLVFDEC-GITDDQLLALLPSLSHCSQLTTLSFYGNSIS 419
Query: 234 TDHSREVLEQLVGPNKLKQVTWTV 257
+ +L+ L+G + L V + V
Sbjct: 420 ISALQSLLQHLIGLSNLTHVLYPV 443
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 33.9 bits (76), Expect = 0.14
Identities = 49/235 (20%), Positives = 89/235 (37%), Gaps = 40/235 (17%)
Query: 16 WCFMKNISRY--LTDIKPLPPNIKDRLIKIMSMQGQITDSNISE-----ILH--PEVQTL 66
WC K + L+ K + P +IK + ++ +NIS+ +++ P ++ L
Sbjct: 923 WCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDL 982
Query: 67 DLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCC 126
L C S + L S+C L+ L+L + G + + + A + + L+
Sbjct: 983 LLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMT 1042
Query: 127 N-------LTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQV 179
+ +TD + + + LL +DL C +TD S
Sbjct: 1043 DFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQS--------------------- 1081
Query: 180 SDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLIT 234
S ++ V L E++M C LTD + L + ++ GC IT
Sbjct: 1082 --SNLLTAVGSSTRYSLTELNMAGCNKLTDQTL-IYLRRIANVTLIDLRGCKQIT 1133
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 33.9 bits (76), Expect = 0.14
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 22/120 (18%)
Query: 60 HPE--VQTLDLRSCDISDAALLHLSNC--RKLKKLNLNASKGNRVSVTSEGIKAVASSC- 114
HPE +QTL L SC+++ L++SN R + LN S N + +G++ + +
Sbjct: 755 HPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNN---LLDDGVQLLCEALR 811
Query: 115 ---SYLHEASLKRCCNLTDEGVVALALN----------CQLLKIIDLGGCLSITDVSLHA 161
YL SL+ C LT+ G L+L C ++ GG ++D HA
Sbjct: 812 HPKCYLERLSLE-SCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHA 870
>gi|28416956 GTPase, IMAP family member 8 [Homo sapiens]
Length = 665
Score = 33.9 bits (76), Expect = 0.14
Identities = 26/94 (27%), Positives = 40/94 (42%)
Query: 69 RSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCNL 128
+SC +S+ LL L CR K NA G V + + V C +R +
Sbjct: 4 QSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVV 63
Query: 129 TDEGVVALALNCQLLKIIDLGGCLSITDVSLHAL 162
D + ++ C K ++ CL ++ SLHAL
Sbjct: 64 IDTPDLFSSIACAEDKQRNIQHCLELSAPSLHAL 97
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 33.1 bits (74), Expect = 0.25
Identities = 51/223 (22%), Positives = 95/223 (42%), Gaps = 29/223 (13%)
Query: 48 GQITDSNISEILHP--EVQTLDLRSCDISDAALLHLSNCR----KLKKLNLNASKGNRVS 101
G + ++SE L ++ LDL I DA + HL+ +L+K++L+ + S
Sbjct: 1591 GDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN-----S 1645
Query: 102 VTSEGIKAVASS---CSYLHEASLKRCCNLTDEGVVALALNC-QLLKIIDL-------GG 150
++S G +A S C L E L C L D + LA Q L+++ L GG
Sbjct: 1646 ISSAGGVQLAESLVLCRRLEELMLG-CNALGDPTALGLAQELPQHLRVLHLPFSHLGPGG 1704
Query: 151 CLSITDVSLHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDG 210
LS+ P L+ + + ++ + + P ++++ + N T
Sbjct: 1705 ALSLAQAL-----DGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSC-KIDNQTAK 1758
Query: 211 AVEAVLTYCPQIRILLFHGCPLITDHSREVLEQLVGPNKLKQV 253
+ + T CP + ++L L + + E+ + L +LK+V
Sbjct: 1759 LLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRV 1801
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,474,594
Number of Sequences: 37866
Number of extensions: 370539
Number of successful extensions: 1027
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 827
Number of HSP's gapped (non-prelim): 122
length of query: 258
length of database: 18,247,518
effective HSP length: 100
effective length of query: 158
effective length of database: 14,460,918
effective search space: 2284825044
effective search space used: 2284825044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.