Guide to the Human Genome
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Search of human proteins with 164420691

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
         (1171 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...  2365   0.0  
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...  2351   0.0  
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...  1415   0.0  
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...  1247   0.0  
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...  1108   0.0  
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...  1100   0.0  
gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [...   880   0.0  
gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [...   825   0.0  
gi|169171014 PREDICTED: similar to homeodomain interacting prote...   736   0.0  
gi|169171552 PREDICTED: similar to homeodomain interacting prote...   502   e-142
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   335   2e-91
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...   222   2e-57
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...   222   2e-57
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...   222   2e-57
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...   222   2e-57
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...   222   2e-57
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...   210   6e-54
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...   209   9e-54
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   207   4e-53
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...   204   3e-52
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   204   5e-52
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   204   5e-52
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...   194   3e-49
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...   194   3e-49
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]               171   3e-42
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                171   3e-42
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      169   2e-41
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          166   1e-40
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          157   4e-38
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               151   4e-36

>gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo
            sapiens]
          Length = 1171

 Score = 2365 bits (6130), Expect = 0.0
 Identities = 1171/1171 (100%), Positives = 1171/1171 (100%)

Query: 1    MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
            MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1    MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60

Query: 61   QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
            QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61   QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120

Query: 121  SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
            SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121  SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180

Query: 181  EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
            EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181  EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240

Query: 241  QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
            QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241  QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300

Query: 301  IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
            IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301  IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360

Query: 361  YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420
            YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
Sbjct: 361  YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420

Query: 421  AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480
            AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
Sbjct: 421  AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480

Query: 481  MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
            MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
Sbjct: 481  MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540

Query: 541  VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM 600
            VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM
Sbjct: 541  VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM 600

Query: 601  AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT 660
            AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT
Sbjct: 601  AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT 660

Query: 661  QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ 720
            QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ
Sbjct: 661  QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ 720

Query: 721  LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH 780
            LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH
Sbjct: 721  LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH 780

Query: 781  QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT 840
            QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT
Sbjct: 781  QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT 840

Query: 841  RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS 900
            RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS
Sbjct: 841  RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS 900

Query: 901  DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV 960
            DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV
Sbjct: 901  DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV 960

Query: 961  PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI 1020
            PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI
Sbjct: 961  PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI 1020

Query: 1021 TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA 1080
            TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA
Sbjct: 1021 TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA 1080

Query: 1081 PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF 1140
            PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF
Sbjct: 1081 PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF 1140

Query: 1141 AHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
            AHQTYISASPASTVYTGYPLSPAKVNQYPYI
Sbjct: 1141 AHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo
            sapiens]
          Length = 1198

 Score = 2351 bits (6092), Expect = 0.0
 Identities = 1171/1198 (97%), Positives = 1171/1198 (97%), Gaps = 27/1198 (2%)

Query: 1    MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
            MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1    MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60

Query: 61   QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
            QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61   QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120

Query: 121  SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
            SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121  SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180

Query: 181  EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
            EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181  EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240

Query: 241  QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
            QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241  QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300

Query: 301  IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
            IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301  IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360

Query: 361  YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420
            YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
Sbjct: 361  YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420

Query: 421  AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480
            AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
Sbjct: 421  AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480

Query: 481  MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
            MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
Sbjct: 481  MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540

Query: 541  VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN------- 593
            VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN       
Sbjct: 541  VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 600

Query: 594  --------------------QPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 633
                                QPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
Sbjct: 601  ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 660

Query: 634  GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 693
            GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
Sbjct: 661  GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 720

Query: 694  QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 753
            QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
Sbjct: 721  QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 780

Query: 754  QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 813
            QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
Sbjct: 781  QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 840

Query: 814  RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 873
            RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
Sbjct: 841  RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 900

Query: 874  KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 933
            KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
Sbjct: 901  KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 960

Query: 934  TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 993
            TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
Sbjct: 961  TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 1020

Query: 994  ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1053
            ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
Sbjct: 1021 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1080

Query: 1054 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1113
            GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
Sbjct: 1081 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1140

Query: 1114 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
            VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Sbjct: 1141 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1198


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo
            sapiens]
          Length = 1210

 Score = 1415 bits (3663), Expect = 0.0
 Identities = 774/1257 (61%), Positives = 896/1257 (71%), Gaps = 140/1257 (11%)

Query: 8    MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
            MAS +QVFSP ++ SSAFCS KKLKIEPS  WD++G  S+ K Y+ SK +P +Q      
Sbjct: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56

Query: 68   STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124
            ++S  V N ++P Y+Q ++ P  +  HIVVT+A SS S           L  RS VSLL+
Sbjct: 57   NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116

Query: 125  TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184
             YQKCGLKRKSEE+++  SVQIIEEHPP++  N +    A ATT+T T+K+S S+ EGDY
Sbjct: 117  PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175

Query: 185  QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244
            QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 176  QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235

Query: 245  SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304
            SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 236  SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295

Query: 305  LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364
            LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 296  LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355

Query: 365  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 424
            RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL
Sbjct: 356  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 415

Query: 425  LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTD 484
            LSAGTKTTRFFNRD +  YPLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TD
Sbjct: 416  LSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTD 475

Query: 485  LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSC 544
            LEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSC
Sbjct: 476  LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSC 535

Query: 545  FQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPS-------- 596
            FQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL TVHNQ S        
Sbjct: 536  FQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTA 595

Query: 597  -------------------------AASMAAVAQRSMPLQTGTAQICARPDPFQQALIVC 631
                                     AA +  VAQ+ + LQ GT QIC + DPFQQ  IVC
Sbjct: 596  AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVC 655

Query: 632  PPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------- 677
            PP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+L Q             
Sbjct: 656  PPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714

Query: 678  --------------------------------QAWPSGTQQILLPPAWQQLTGVATHTSV 705
                                            QAWP GTQQILLP  WQQL GVA H SV
Sbjct: 715  QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSV 774

Query: 706  QHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMR 765
            Q   +IPE M   QQLADWRN H+HG+ Y+ IMQQP+LLT HVTL  AQPLNVGVAHV+R
Sbjct: 775  QPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVR 834

Query: 766  QQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACS 825
            QQ +S+  S+K+KQ  + V + S+ +V  SQ  S                 +V SSP  +
Sbjct: 835  QQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRT 876

Query: 826  TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQR 885
            TS         S    + Q Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+  K R
Sbjct: 877  TS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPR 930

Query: 886  KNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVP 943
             NVIS VTV+DSP SDSS  +SPYS    +    N+ +  +  G +    TG  RTIIVP
Sbjct: 931  SNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVP 988

Query: 944  PLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP 1003
            PLKTQ  +  V          +  +S   S  +  V S SG SSG       YR QR G 
Sbjct: 989  PLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT 1038

Query: 1004 HFQQQQPLNLSQAQQHI---TTDRTGSH---RRQQAYITPTMAQAPYSFPHNSPSHGTVH 1057
                 QPLNLSQ QQ     T+    S+   RRQQA++ P ++QAPY+F H SP H T H
Sbjct: 1039 --SAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGH 1095

Query: 1058 PHLAAAAAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQGSARHTVQHTAYPASIV 1114
            PHL  A A AHLP+Q HLYTY AP   AALGST ++AHL + QGS+RH   +T +P+++V
Sbjct: 1096 PHL--APAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLV 1153

Query: 1115 HQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
            HQVPVS+GP +L S ++ P+QY  QFA Q+YI +S  ST+YTGYPLSP K++QY Y+
Sbjct: 1154 HQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1210


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [Homo
            sapiens]
          Length = 1075

 Score = 1247 bits (3226), Expect = 0.0
 Identities = 685/1092 (62%), Positives = 779/1092 (71%), Gaps = 128/1092 (11%)

Query: 8    MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
            MAS +QVFSP ++ SSAFCS KKLKIEPS  WD++G  S+ K Y+ SK +P +Q      
Sbjct: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56

Query: 68   STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124
            ++S  V N ++P Y+Q ++ P  +  HIVVT+A SS S           L  RS VSLL+
Sbjct: 57   NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116

Query: 125  TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184
             YQKCGLKRKSEE+++  SVQIIEEHPP++  N +    A ATT+T T+K+S S+ EGDY
Sbjct: 117  PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175

Query: 185  QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244
            QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 176  QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235

Query: 245  SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304
            SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 236  SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295

Query: 305  LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364
            LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 296  LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355

Query: 365  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 424
            RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL
Sbjct: 356  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 415

Query: 425  LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTD 484
            LSAGTKTTRFFNRD +  YPLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TD
Sbjct: 416  LSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTD 475

Query: 485  LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSC 544
            LEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSC
Sbjct: 476  LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSC 535

Query: 545  FQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPS-------- 596
            FQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL TVHNQ S        
Sbjct: 536  FQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTA 595

Query: 597  -------------------------AASMAAVAQRSMPLQTGTAQICARPDPFQQALIVC 631
                                     AA +  VAQ+ + LQ GT QIC + DPFQQ  IVC
Sbjct: 596  AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVC 655

Query: 632  PPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------- 677
            PP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+L Q             
Sbjct: 656  PPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714

Query: 678  --------------------------------QAWPSGTQQILLPPAWQQLTGVATHTSV 705
                                            QAWP GTQQILLP  WQQL GVA H SV
Sbjct: 715  QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSV 774

Query: 706  QHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMR 765
            Q   +IPE M   QQLADWRN H+HG+ Y+ IMQQP+LLT HVTL  AQPLNVGVAHV+R
Sbjct: 775  QPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVR 834

Query: 766  QQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACS 825
            QQ +S+  S+K+KQ  + V + S+ +V  SQ  S                 +V SSP  +
Sbjct: 835  QQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRT 876

Query: 826  TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQR 885
            TS         S    + Q Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+  K R
Sbjct: 877  TS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPR 930

Query: 886  KNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVP 943
             NVIS VTV+DSP SDSS  +SPYS    +    N+ +  +  G +    TG  RTIIVP
Sbjct: 931  SNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVP 988

Query: 944  PLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP 1003
            PLKTQ  +  V          +  +S   S  +  V S SG SSG       YR QR G 
Sbjct: 989  PLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT 1038

Query: 1004 HFQQQQPLNLSQ 1015
                 QPLNLSQ
Sbjct: 1039 --SAAQPLNLSQ 1048


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2 [Homo
            sapiens]
          Length = 1194

 Score = 1108 bits (2866), Expect = 0.0
 Identities = 646/1240 (52%), Positives = 794/1240 (64%), Gaps = 122/1240 (9%)

Query: 8    MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
            MAS V V+ P+  Q  SSAFCSVKKLK+EPSS   +    ++ + Y   +N   S P T 
Sbjct: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58

Query: 65   -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
             +   T +P   P     SL     +V   + G   V +A +     Q    P     R+
Sbjct: 59   GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114

Query: 119  TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
             +  L+  Q+CGLKRKSEE++N SS +QI++E    P M+Q N     TV TATT    S
Sbjct: 115  RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171

Query: 174  KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
            K + +  EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 172  KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231

Query: 234  PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
            PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 232  PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291

Query: 294  SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
            SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 292  SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351

Query: 354  SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
            SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 352  SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411

Query: 414  SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
            SQTQGLP E LL+ GTK+TRFF ++TD  +  WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 412  SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471

Query: 474  DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533
            DD+A VN   DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 472  DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531

Query: 534  DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593
            DFPHS HVKSCF  M+ICK  +N  DT N +KT  +  VA S++  LT  F  ++ T+ +
Sbjct: 532  DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590

Query: 594  QPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRM 652
            Q    S  +V    +PLQ GTAQ  C   D FQQ LI+CPP  QG+ A+  K   YS+R+
Sbjct: 591  QALTTSAHSVVHHGIPLQAGTAQFGCG--DAFQQTLIICPPAIQGIPATHGKPTSYSIRV 648

Query: 653  ENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIP 712
            +N VP+VTQAP  QPLQI+PG+L+ Q W   TQQ+L+ PAWQQ+T +A  T+    T+  
Sbjct: 649  DNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQQMLV-PAWQQVTPLAPATT----TLTS 702

Query: 713  ETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 772
            E++AG+ +L DW    +  +HYN +M QP LLT  +TL A QP++VG+AHV+  QP +T 
Sbjct: 703  ESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGIAHVVWPQPATTK 761

Query: 773  SSRKSKQHQSSVRNVSTCEVSSSQAISSPQ--RSKRVK-----ENTPPRCAMVHSSPACS 825
             +++ +   +S++N +        A  SP+    K V+     E    + +   +   C 
Sbjct: 762  KNKQCQNRSNSLQNTNI----PHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCE 817

Query: 826  TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEE-EQKH--------- 875
            TS+       + S+  ++QRQTI+I D+PSP VSVITISSDTDEEE  Q+H         
Sbjct: 818  TSIR----QDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSL 873

Query: 876  ------------------APTSTVSK-----------QRKNVI-------SCVTVHDSPY 899
                              +P ST+S            +R N +       SC TV  SP 
Sbjct: 874  DCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPT 933

Query: 900  SDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSL 959
            SDSS + SP++        + N  +   S +        +++VPP++ +           
Sbjct: 934  SDSSGHDSPFAESTFVEDTHENT-ELVSSADTETKPAVCSVVVPPVELENG--------- 983

Query: 960  VPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQ- 1018
              +N   H ++  S     +   S     +   A+  RQQ+    FQQQ  LN SQ Q  
Sbjct: 984  --LNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQH-LNFSQVQHF 1040

Query: 1019 ---HITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHL 1075
               H   +    HRRQQAYI  ++   P++  H SP+H  VH HL   A   HL  QP L
Sbjct: 1041 GSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHL---AGNTHLGGQPTL 1097

Query: 1076 YTYTAPAALGSTGTVAHLVASQGSARHTVQHTAY----PASIVHQVPVSMGPRVLPSPTI 1131
              Y + A L S   VAHL+AS  ++R  +QH  Y    P+ IVHQVPV + PR+LPSPTI
Sbjct: 1098 LPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTI 1157

Query: 1132 HPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
            H +QY   F   +YI+ASPA   YTG+PLSP K++QYPY+
Sbjct: 1158 HQTQYKPIFPPHSYIAASPA---YTGFPLSPTKLSQYPYM 1194


>gi|114796624 homeodomain interacting protein kinase 3 isoform 1 [Homo
            sapiens]
          Length = 1215

 Score = 1100 bits (2845), Expect = 0.0
 Identities = 648/1260 (51%), Positives = 793/1260 (62%), Gaps = 141/1260 (11%)

Query: 8    MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
            MAS V V+ P+  Q  SSAFCSVKKLK+EPSS   +    ++ + Y   +N   S P T 
Sbjct: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58

Query: 65   -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
             +   T +P   P     SL     +V   + G   V +A +     Q    P     R+
Sbjct: 59   GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114

Query: 119  TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
             +  L+  Q+CGLKRKSEE++N SS +QI++E    P M+Q N     TV TATT    S
Sbjct: 115  RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171

Query: 174  KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
            K + +  EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 172  KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231

Query: 234  PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
            PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 232  PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291

Query: 294  SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
            SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 292  SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351

Query: 354  SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
            SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 352  SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411

Query: 414  SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
            SQTQGLP E LL+ GTK+TRFF ++TD  +  WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 412  SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471

Query: 474  DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533
            DD+A VN   DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 472  DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531

Query: 534  DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593
            DFPHS HVKSCF  M+ICK  +N  DT N +KT  +  VA S++  LT  F  ++ T+ +
Sbjct: 532  DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590

Query: 594  QPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRM 652
            Q    S  +V    +PLQ GTAQ  C   D FQQ LI+CPP  QG+ A+  K   YS+R+
Sbjct: 591  QALTTSAHSVVHHGIPLQAGTAQFGCG--DAFQQTLIICPPAIQGIPATHGKPTSYSIRV 648

Query: 653  ENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIP 712
            +N VP+VTQAP  QPLQI+PG+L+ Q W   TQQ+L+ PAWQQ+T +A  T+    T+  
Sbjct: 649  DNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQQMLV-PAWQQVTPLAPATT----TLTS 702

Query: 713  ETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 772
            E++AG+ +L DW    +  +HYN +M QP LLT  +TL A QP++VG+AHV+  QP +T 
Sbjct: 703  ESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGIAHVVWPQPATT- 760

Query: 773  SSRKSKQHQSSVRNVSTCE-VSSSQAISSPQRSKRVKENTPPRCAMV------------- 818
              +K+KQ Q+    V   E     + I++   S  ++    P  A +             
Sbjct: 761  --KKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEV 818

Query: 819  -------------HSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISS 865
                          +   C TS+       + S+  ++QRQTI+I D+PSP VSVITISS
Sbjct: 819  SCIETQDNQNSEGEARNCCETSIR----QDSDSSVSDKQRQTIIIADSPSPAVSVITISS 874

Query: 866  DTDEEE-EQKH---------------------------APTSTVSK-----------QRK 886
            DTDEEE  Q+H                           +P ST+S            +R 
Sbjct: 875  DTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRP 934

Query: 887  NVI-------SCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRT 939
            N +       SC TV  SP SDSS + SP++        + N  +   S +        +
Sbjct: 935  NSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENT-ELVSSADTETKPAVCS 993

Query: 940  IIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQ 999
            ++VPP++ +             +N   H ++  S     +   S     +   A+  RQQ
Sbjct: 994  VVVPPVELENG-----------LNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQ 1042

Query: 1000 RPGPHFQQQQPLNLSQAQQ----HITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGT 1055
            +    FQQQ  LN SQ Q     H   +    HRRQQAYI  ++   P++  H SP+H  
Sbjct: 1043 KLTSAFQQQH-LNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTA 1101

Query: 1056 VHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAY----PA 1111
            VH HL   A   HL  QP L  Y + A L S   VAHL+AS  ++R  +QH  Y    P+
Sbjct: 1102 VHAHL---AGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPS 1158

Query: 1112 SIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
             IVHQVPV + PR+LPSPTIH +QY   F   +YI+ASPA   YTG+PLSP K++QYPY+
Sbjct: 1159 GIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGFPLSPTKLSQYPYM 1215


>gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [Homo
            sapiens]
          Length = 836

 Score =  880 bits (2275), Expect = 0.0
 Identities = 496/878 (56%), Positives = 581/878 (66%), Gaps = 132/878 (15%)

Query: 384  MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPY 443
            MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRD +  Y
Sbjct: 1    MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY 60

Query: 444  PLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDL 503
            PLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TDLEG+DML EKADRRE+IDL
Sbjct: 61   PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL 120

Query: 504  LKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQ 563
            LKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSCFQNMEICKRRV+MYDTV+Q
Sbjct: 121  LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ 180

Query: 564  SKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPS--------------------------- 596
             K+PF THVAP+TSTNLTM+F+NQL TVHNQ S                           
Sbjct: 181  IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS 240

Query: 597  ------AASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ-GLQASPSKHAGYS 649
                  AA +  VAQ+ + LQ GT QIC + DPFQQ  IVCPP FQ GLQA+ +KH+G+ 
Sbjct: 241  ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFP 299

Query: 650  VRMENAVPIVTQAPGAQPLQIQPGLLAQ-------------------------------- 677
            VRM+NAVPIV QAP AQPLQIQ G+L Q                                
Sbjct: 300  VRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAA 359

Query: 678  -------------QAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADW 724
                         QAWP GTQQILLP  WQQL GVA H SVQ   +IPE M   QQLADW
Sbjct: 360  GRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADW 419

Query: 725  RNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSV 784
            RN H+HG+ Y+ IMQQP+LLT HVTL  AQPLNVGVAHV+RQQ +S+  S+K+KQ  + V
Sbjct: 420  RNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQ-SAPV 478

Query: 785  RNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQ 844
             + S+ +V  SQ  S                 +V SSP  +TS         S    + Q
Sbjct: 479  SSKSSLDVLPSQVYS-----------------LVGSSPLRTTS------SYNSLVPVQDQ 515

Query: 845  RQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSS 904
             Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+  K R NVIS VTV+DSP SDSS 
Sbjct: 516  HQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSL 575

Query: 905  NTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPV 962
             +SPYS    +    N+ +  +  G +    TG  RTIIVPPLKTQ  +  V        
Sbjct: 576  -SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVPPLKTQLGDCTV-------- 625

Query: 963  NTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI-- 1020
              +  +S   S  +  V S SG SSG       YR QR G      QPLNLSQ QQ    
Sbjct: 626  --ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT--SAAQPLNLSQNQQSSAA 681

Query: 1021 -TTDRTGSH---RRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLY 1076
             T+    S+   RRQQA++ P ++QAPY+F H SP H T HPHL  A A AHLP+Q HLY
Sbjct: 682  PTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGHPHL--APAPAHLPSQAHLY 738

Query: 1077 TYTAP---AALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHP 1133
            TY AP   AALGST ++AHL + QGS+RH   +T +P+++VHQVPVS+GP +L S ++ P
Sbjct: 739  TYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAP 798

Query: 1134 SQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
            +QY  QFA Q+YI +S  ST+YTGYPLSP K++QY Y+
Sbjct: 799  AQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 836


>gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [Homo
            sapiens]
          Length = 816

 Score =  825 bits (2131), Expect = 0.0
 Identities = 471/853 (55%), Positives = 556/853 (65%), Gaps = 132/853 (15%)

Query: 409  QIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKY 468
            QIRYISQTQGLPAEYLLSAGTKTTRFFNRD +  YPLWRLKTP++HE ETGIKSKEARKY
Sbjct: 6    QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY 65

Query: 469  IFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
            IFNCLDDMAQVNM+TDLEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVT
Sbjct: 66   IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 125

Query: 529  MTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQL 588
            MTHLLDFPHS HVKSCFQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL
Sbjct: 126  MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL 185

Query: 589  TTVHNQPS---------------------------------AASMAAVAQRSMPLQTGTA 615
             TVHNQ S                                 AA +  VAQ+ + LQ GT 
Sbjct: 186  NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT 245

Query: 616  QICARPDPFQQALIVCPPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGL 674
            QIC + DPFQQ  IVCPP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+
Sbjct: 246  QICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGV 304

Query: 675  LAQ---------------------------------------------QAWPSGTQQILL 689
            L Q                                             QAWP GTQQILL
Sbjct: 305  LTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILL 364

Query: 690  PPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVT 749
            P  WQQL GVA H SVQ   +IPE M   QQLADWRN H+HG+ Y+ IMQQP+LLT HVT
Sbjct: 365  PSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVT 424

Query: 750  LPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKE 809
            L  AQPLNVGVAHV+RQQ +S+  S+K+KQ  + V + S+ +V  SQ  S          
Sbjct: 425  LATAQPLNVGVAHVVRQQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS---------- 473

Query: 810  NTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDE 869
                   +V SSP  +TS         S    + Q Q I+IPDTPSP VSVITI SDTDE
Sbjct: 474  -------LVGSSPLRTTS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE 520

Query: 870  EEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKG 927
            EE+ K+ P+S+  K R NVIS VTV+DSP SDSS  +SPYS    +    N+ +  +  G
Sbjct: 521  EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPG 579

Query: 928  SLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSS 987
             +    TG  RTIIVPPLKTQ  +  V          +  +S   S  +  V S SG SS
Sbjct: 580  RVVADGTGT-RTIIVPPLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSS 628

Query: 988  GSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI---TTDRTGSH---RRQQAYITPTMAQ 1041
            G       YR QR G      QPLNLSQ QQ     T+    S+   RRQQA++ P ++Q
Sbjct: 629  GCCITPTGYRAQRGGT--SAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQ 685

Query: 1042 APYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQG 1098
            APY+F H SP H T HPHL  A A AHLP+Q HLYTY AP   AALGST ++AHL + QG
Sbjct: 686  APYTFQHGSPLHSTGHPHL--APAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQG 743

Query: 1099 SARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGY 1158
            S+RH   +T +P+++VHQVPVS+GP +L S ++ P+QY  QFA Q+YI +S  ST+YTGY
Sbjct: 744  SSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGY 803

Query: 1159 PLSPAKVNQYPYI 1171
            PLSP K++QY Y+
Sbjct: 804  PLSPTKISQYSYL 816


>gi|169171014 PREDICTED: similar to homeodomain interacting protein
           kinase 2 [Homo sapiens]
          Length = 460

 Score =  736 bits (1901), Expect = 0.0
 Identities = 368/368 (100%), Positives = 368/368 (100%)

Query: 1   MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
           MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1   MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60

Query: 61  QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
           QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61  QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120

Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
           SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180

Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
           EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240

Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
           QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300

Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
           IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360

Query: 361 YLQSRYYR 368
           YLQSRYYR
Sbjct: 361 YLQSRYYR 368


>gi|169171552 PREDICTED: similar to homeodomain interacting protein
           kinase 3 [Homo sapiens]
          Length = 264

 Score =  502 bits (1293), Expect = e-142
 Identities = 252/252 (100%), Positives = 252/252 (100%)

Query: 8   MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
           MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV
Sbjct: 1   MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 60

Query: 68  STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ 127
           STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ
Sbjct: 61  STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ 120

Query: 128 KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV 187
           KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
Sbjct: 121 KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV 180

Query: 188 QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL 247
           QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL
Sbjct: 181 QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL 240

Query: 248 ARLSTESADDYN 259
           ARLSTESADDYN
Sbjct: 241 ARLSTESADDYN 252


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  335 bits (858), Expect = 2e-91
 Identities = 178/356 (50%), Positives = 237/356 (66%), Gaps = 10/356 (2%)

Query: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253
           S T+ Y+++E LG+GTFG+V K W+R T E+VAIKILKN     R  + E+ +L  +   
Sbjct: 6   SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65

Query: 254 SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALM 313
             ++ + +R  E F       LVFE+LEQNL++F K+N F+PLP ++IR V  QV TAL 
Sbjct: 66  DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125

Query: 314 KLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 371
           +LK L +IHADLKPENIMLVD +R P+RVKVIDFGSAS  S+   V   Y+QSR+YRAPE
Sbjct: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185

Query: 372 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 431
           I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP  +LL A  K 
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245

Query: 432 TRFFNRD--TDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN-----MTTD 484
             FF R+   D+  P W+LK+  D+ AET ++  E RKY+   LD +  VN         
Sbjct: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304

Query: 485 LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
               + L E AD +  ++L+K+MLT ++ +RI+P   L HPFV+M  L     +TH
Sbjct: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score =  222 bits (565), Expect = 2e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score =  222 bits (565), Expect = 2e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score =  222 bits (565), Expect = 2e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 5/97 (5%)

Query: 915  AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 971
            +GH  A+    K  +      +P+T I P    Q S      D     NTS+    S + 
Sbjct: 442  SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499

Query: 972  KSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQ 1008
            +   SS  TS++  SSG SSG     + R  P  Q +
Sbjct: 500  EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHR 536


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score =  222 bits (565), Expect = 2e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 387 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434

Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)

Query: 915  AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 971
            +GH  A+    K  +      +P+T I P    Q S      D     NTS+    S + 
Sbjct: 433  SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 490

Query: 972  KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1006
            +   SS  TS++  SSG SSG           T++ +  G HF                +
Sbjct: 491  EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 550

Query: 1007 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1064
            QQ P  L  +     T  T  +H  Q+        Q      H NS  H   H H     
Sbjct: 551  QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 610

Query: 1065 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1118
                L  +     Y +P    ST      G   H + S  S+  T   +   +S  +Q  
Sbjct: 611  GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 668

Query: 1119 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1169
             +   R + + T+   Q  A   + T  S     T   G+P      N  P
Sbjct: 669  QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 719


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score =  222 bits (565), Expect = 2e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)

Query: 915  AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 971
            +GH  A+    K  +      +P+T I P    Q S      D     NTS+    S + 
Sbjct: 442  SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499

Query: 972  KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1006
            +   SS  TS++  SSG SSG           T++ +  G HF                +
Sbjct: 500  EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 559

Query: 1007 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1064
            QQ P  L  +     T  T  +H  Q+        Q      H NS  H   H H     
Sbjct: 560  QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 619

Query: 1065 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1118
                L  +     Y +P    ST      G   H + S  S+  T   +   +S  +Q  
Sbjct: 620  GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 677

Query: 1119 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1169
             +   R + + T+   Q  A   + T  S     T   G+P      N  P
Sbjct: 678  QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 728


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score =  210 bits (535), Expect = 6e-54
 Identities = 122/336 (36%), Positives = 183/336 (54%), Gaps = 16/336 (4%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++    +  
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 436 NRDTDSPYPLWRLK-TPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK 494
            R     + L R K    D++     + +E             Q          +     
Sbjct: 348 ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG---------VQTGGPGGRRAGEPGHSP 398

Query: 495 ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
           AD   F DL+ +ML  +   RI+P+  L H F   T
Sbjct: 399 ADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score =  209 bits (533), Expect = 9e-54
 Identities = 124/335 (37%), Positives = 183/335 (54%), Gaps = 42/335 (12%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++    +  
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKA 495
            R    P   W L+           ++KE RK                D +G        
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371

Query: 496 DRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
            RR   DL+ +ML  +   RI+P+  L H F   T
Sbjct: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  207 bits (528), Expect = 4e-53
 Identities = 127/356 (35%), Positives = 184/356 (51%), Gaps = 37/356 (10%)

Query: 173 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 232
           SK S  +  G Y  V H+    +   YEVLE +G+G+FGQV KC     NE+VA+KI++N
Sbjct: 81  SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137

Query: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQN 291
              + +Q  +E+ IL  L  +  D+ YN V   + F  +NH C+ FE+L  NLY+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197

Query: 292 KFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS 351
            F    L  +R     V   L  L    +IH DLKPENI+L    +    VKVIDFGS+ 
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSC 255

Query: 352 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 411
           +  + V  TY+QSR+YR+PE+ILG P+  AIDMWSLGC+ AEL+ G+PL+PG +E +Q+ 
Sbjct: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314

Query: 412 YISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFN 471
            I +  GLP    +   ++   FF                D       I +   +K  + 
Sbjct: 315 CIMEVLGLPPAGFIQTASRRQTFF----------------DSKGFPKNITNNRGKKR-YP 357

Query: 472 CLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV 527
              D+  V  T D               F+D L++ L  +   R+TP + L H ++
Sbjct: 358 DSKDLTMVLKTYD-------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score =  204 bits (520), Expect = 3e-52
 Identities = 120/335 (35%), Positives = 178/335 (53%), Gaps = 54/335 (16%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++    +  
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKA 495
            R    P   W L+           ++KE RK                            
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRK---------------------------- 365

Query: 496 DRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
                 DL+ +ML  +   RI+P+  L H F   T
Sbjct: 366 ------DLVLRMLEYEPAARISPLGALQHGFFRRT 394


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  204 bits (518), Expect = 5e-52
 Identities = 126/362 (34%), Positives = 189/362 (52%), Gaps = 25/362 (6%)

Query: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
           T    N G  + +G Y  V H+    +   YEVL+ +G+G+FGQVVK +    ++ VA+K
Sbjct: 195 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 251

Query: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
           +++N   + RQ   E+ IL  L  +  D+  N +   E F  +NH C+ FE+L  NLY+ 
Sbjct: 252 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 311

Query: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
           +K+NKF    L  +R     +   L  L    +IH DLKPENI+L    R    +KVIDF
Sbjct: 312 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 369

Query: 348 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 407
           GS+ +  + V  TY+QSR+YRAPE+ILG  +   IDMWSLGC++AEL  G+PL PG  E 
Sbjct: 370 GSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEG 428

Query: 408 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT--PDDHEAETGIKSKEA 465
           DQ+  + +  G+P++ LL A  +   F    +   YP +   T   D      G +S+  
Sbjct: 429 DQLACMIELLGMPSQKLLDASKRAKNFV---SSKGYPRYCTVTTLSDGSVVLNGGRSRRG 485

Query: 466 RKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHP 525
           +            +    +       ++  D   F+D LK+ L  D   R+TP + L HP
Sbjct: 486 K------------LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHP 533

Query: 526 FV 527
           ++
Sbjct: 534 WL 535


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  204 bits (518), Expect = 5e-52
 Identities = 126/362 (34%), Positives = 189/362 (52%), Gaps = 25/362 (6%)

Query: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
           T    N G  + +G Y  V H+    +   YEVL+ +G+G+FGQVVK +    ++ VA+K
Sbjct: 122 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 178

Query: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
           +++N   + RQ   E+ IL  L  +  D+  N +   E F  +NH C+ FE+L  NLY+ 
Sbjct: 179 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 238

Query: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
           +K+NKF    L  +R     +   L  L    +IH DLKPENI+L    R    +KVIDF
Sbjct: 239 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 296

Query: 348 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 407
           GS+ +  + V  TY+QSR+YRAPE+ILG  +   IDMWSLGC++AEL  G+PL PG  E 
Sbjct: 297 GSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEG 355

Query: 408 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT--PDDHEAETGIKSKEA 465
           DQ+  + +  G+P++ LL A  +   F    +   YP +   T   D      G +S+  
Sbjct: 356 DQLACMIELLGMPSQKLLDASKRAKNFV---SSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412

Query: 466 RKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHP 525
           +            +    +       ++  D   F+D LK+ L  D   R+TP + L HP
Sbjct: 413 K------------LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHP 460

Query: 526 FV 527
           ++
Sbjct: 461 WL 462


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score =  194 bits (494), Expect = 3e-49
 Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)

Query: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
           N+G   + D   + H     +   YEVL+ +G+G+FGQV + +     + VA+K+++N  
Sbjct: 166 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 224

Query: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
            + RQ   E+ IL  L  +      N +   E F  +NH C+ FE+L  +LY+ +K+NKF
Sbjct: 225 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 284

Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
               ++ +R   Q +  +L  L    +IH DLKPENI+L    R     KVIDFGS+   
Sbjct: 285 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 342

Query: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
            + +  TY+QSR+YRAPEIILG  +   ID+WS GC++AEL  G PL+PG  E DQ+  +
Sbjct: 343 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 401

Query: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
            +  G+P   LL   +K  ++F      P         D      G +S+  +K      
Sbjct: 402 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 455

Query: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
                 +  T L+G D  +       FI+ LK+ L  D   R+TP + L HP+++
Sbjct: 456 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 503


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score =  194 bits (494), Expect = 3e-49
 Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)

Query: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
           N+G   + D   + H     +   YEVL+ +G+G+FGQV + +     + VA+K+++N  
Sbjct: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244

Query: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
            + RQ   E+ IL  L  +      N +   E F  +NH C+ FE+L  +LY+ +K+NKF
Sbjct: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304

Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
               ++ +R   Q +  +L  L    +IH DLKPENI+L    R     KVIDFGS+   
Sbjct: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 362

Query: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
            + +  TY+QSR+YRAPEIILG  +   ID+WS GC++AEL  G PL+PG  E DQ+  +
Sbjct: 363 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421

Query: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
            +  G+P   LL   +K  ++F      P         D      G +S+  +K      
Sbjct: 422 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 475

Query: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
                 +  T L+G D  +       FI+ LK+ L  D   R+TP + L HP+++
Sbjct: 476 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 523


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score =  171 bits (434), Expect = 3e-42
 Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)

Query: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
           YE+++ LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T   + 
Sbjct: 203 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 262

Query: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L +IR +  Q+  ++  L 
Sbjct: 263 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 322

Query: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
           S  L H DLKPENI+ V     + Y               +KV+DFGSA++  +   ST 
Sbjct: 323 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 381

Query: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 382 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 441

Query: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
           ++++   T+  ++F+ D       W     D+H +        A +Y+      + +  +
Sbjct: 442 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 483

Query: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
           + D+E               DL++KML  D  KRIT  E L HPF
Sbjct: 484 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 518


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score =  171 bits (434), Expect = 3e-42
 Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)

Query: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
           YE+++ LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T   + 
Sbjct: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220

Query: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L +IR +  Q+  ++  L 
Sbjct: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280

Query: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
           S  L H DLKPENI+ V     + Y               +KV+DFGSA++  +   ST 
Sbjct: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339

Query: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399

Query: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
           ++++   T+  ++F+ D       W     D+H +        A +Y+      + +  +
Sbjct: 400 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 441

Query: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
           + D+E               DL++KML  D  KRIT  E L HPF
Sbjct: 442 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 476


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  169 bits (427), Expect = 2e-41
 Identities = 117/359 (32%), Positives = 189/359 (52%), Gaps = 25/359 (6%)

Query: 174  KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 232
            +++ +++EG Y++   EVL      Y V  + G+G F  VV+       N+ VA+KI++N
Sbjct: 665  RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721

Query: 233  HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ- 290
            +    + G  E+  L +L+    DD ++ +R +  F HK H CLVFE L  NL + LK+ 
Sbjct: 722  NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781

Query: 291  NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA 350
             K   L +K +R   QQ+  AL  LK   ++HAD+KP+NI LV+ S+    +K+ DFGSA
Sbjct: 782  GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKTI--LKLCDFGSA 838

Query: 351  SHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI 410
            SHV+    + YL SR+YRAPEII+G  +   IDMWS+GC + EL+ G  L+PG +    +
Sbjct: 839  SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898

Query: 411  RYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIF 470
            +     +G     ++  G    + F+++ +  Y    +    + E  T + +    K   
Sbjct: 899  KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY--IEVDKVTEREKVTVMSTINPTK--- 953

Query: 471  NCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFV 527
                     ++  DL G   L E   ++  +  DLL ++L +D  KRI+  + L H F+
Sbjct: 954  ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  166 bits (420), Expect = 1e-40
 Identities = 104/345 (30%), Positives = 174/345 (50%), Gaps = 46/345 (13%)

Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-STESAD 256
           YE+++ LG G FG+VV+C   G + + VA+KI+KN   Y    + E+ +L  L ST+   
Sbjct: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218

Query: 257 DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
            +  V+  E F H  H C+VFE+L  + YDF+K+N F P  + +IR +  Q+  ++  L 
Sbjct: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278

Query: 317 SLGLIHADLKPENIMLV---------------DPSRQPYRVKVIDFGSASHVSKAVCSTY 361
              L H DLKPENI+ V               + + +   +KV+DFGSA++  +   ST 
Sbjct: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337

Query: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++      + +  + +  G   
Sbjct: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397

Query: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
           ++++    K   F +   D     W     D+H +        A +Y+      + +   
Sbjct: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLKEF-- 437

Query: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
                   ML    +  +  DL+++ML  D  +RIT  E L HPF
Sbjct: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  157 bits (398), Expect = 4e-38
 Identities = 111/382 (29%), Positives = 192/382 (50%), Gaps = 55/382 (14%)

Query: 165 TATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC--WKRGTN 222
           +++ S+  +K+   ++EG   L+ H V   +   YE++  LG GTFG+VV+C   +RG  
Sbjct: 131 SSSHSSRRAKSVEDDAEG--HLIYH-VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGA 187

Query: 223 EIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNF-VRAYECFQHKNHTCLVFEMLE 281
             VA+KI+KN   Y    ++E+++L +++ +  D+ N  V+ ++ F +  H C+ FE+L 
Sbjct: 188 R-VALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG 246

Query: 282 QNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-------- 333
            + +DFLK N + P P+  +R +  Q+  A+  L    L H DLKPENI+ V        
Sbjct: 247 LSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTY 306

Query: 334 -------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
                  + S +   V+V+DFGSA+       ST + +R+YRAPE+IL L + +  D+WS
Sbjct: 307 NLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 365

Query: 387 LGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLW 446
           +GC+I E ++G+ L+      + +  + +  G P    +   T+  ++F R         
Sbjct: 366 IGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PIPSRMIRKTRKQKYFYRG-------- 416

Query: 447 RLKTPDDHEAETGIKS--KEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLL 504
           RL   ++  A   ++   K  R+Y+ +                     E  +  +  DL+
Sbjct: 417 RLDWDENTSAGRYVRENCKPLRRYLTS---------------------EAEEHHQLFDLI 455

Query: 505 KKMLTIDADKRITPIETLNHPF 526
           + ML  +  KR+T  E L HPF
Sbjct: 456 ESMLEYEPAKRLTLGEALQHPF 477


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  151 bits (381), Expect = 4e-36
 Identities = 108/385 (28%), Positives = 186/385 (48%), Gaps = 55/385 (14%)

Query: 164 ATATTSTATSKNSGSNSEGDYQLVQHEVLCS----MTNTYEVLEFLGRGTFGQVVKCWK- 218
           + ++ S  +SK S  + E D +     ++C     +   YE++  LG GTFG+VV+C   
Sbjct: 268 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 324

Query: 219 -RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLV 276
            RG ++ VA+KI++N   Y    ++E+++L ++  +  ++ +  V   + F    H C+ 
Sbjct: 325 ARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIA 383

Query: 277 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV--- 333
           FE+L +N ++FLK+N F P PL ++R +  Q+  AL  L    L H DLKPENI+ V   
Sbjct: 384 FELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSE 443

Query: 334 ------------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEA 381
                       + S +   ++V DFGSA+       +T + +R+YR PE+IL L + + 
Sbjct: 444 FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQP 502

Query: 382 IDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 441
            D+WS+GC++ E + G+ L+      + +  + +  G    +++    K   F+      
Sbjct: 503 CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL-- 560

Query: 442 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFI 501
              +W      D  +  G   KE  K +                  S ML +  +  +  
Sbjct: 561 ---VW------DENSSDGRYVKENCKPL-----------------KSYMLQDSLEHVQLF 594

Query: 502 DLLKKMLTIDADKRITPIETLNHPF 526
           DL+++ML  D  +RIT  E L HPF
Sbjct: 595 DLMRRMLEFDPAQRITLAEALLHPF 619


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.126    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,889,149
Number of Sequences: 37866
Number of extensions: 2230396
Number of successful extensions: 12609
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 423
Number of HSP's successfully gapped in prelim test: 500
Number of HSP's that attempted gapping in prelim test: 9431
Number of HSP's gapped (non-prelim): 2226
length of query: 1171
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1058
effective length of database: 13,968,660
effective search space: 14778842280
effective search space used: 14778842280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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