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Search of human proteins with 164420685
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
(1198 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 2416 0.0
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 2351 0.0
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 1455 0.0
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 1286 0.0
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 1096 0.0
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 1088 0.0
gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [... 920 0.0
gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [... 865 0.0
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 736 0.0
gi|169171552 PREDICTED: similar to homeodomain interacting prote... 502 e-142
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 335 2e-91
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 222 2e-57
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 222 2e-57
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 222 2e-57
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 222 2e-57
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 222 2e-57
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 210 6e-54
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 209 1e-53
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 207 4e-53
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 204 3e-52
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 204 5e-52
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 204 5e-52
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 194 3e-49
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 194 3e-49
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 171 3e-42
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 171 3e-42
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 169 2e-41
gi|10190706 CDC-like kinase 4 [Homo sapiens] 166 1e-40
gi|47717134 CDC-like kinase 2 [Homo sapiens] 157 4e-38
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 151 4e-36
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo
sapiens]
Length = 1198
Score = 2416 bits (6262), Expect = 0.0
Identities = 1198/1198 (100%), Positives = 1198/1198 (100%)
Query: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
Query: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
Query: 361 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
Sbjct: 361 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420
Query: 421 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
Sbjct: 421 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480
Query: 481 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
Sbjct: 481 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
Query: 541 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 600
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
Sbjct: 541 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 600
Query: 601 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 660
ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
Sbjct: 601 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 660
Query: 661 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 720
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
Sbjct: 661 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 720
Query: 721 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 780
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
Sbjct: 721 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 780
Query: 781 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 840
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
Sbjct: 781 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 840
Query: 841 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 900
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
Sbjct: 841 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 900
Query: 901 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 960
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
Sbjct: 901 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 960
Query: 961 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 1020
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
Sbjct: 961 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 1020
Query: 1021 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1080
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
Sbjct: 1021 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1080
Query: 1081 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1140
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
Sbjct: 1081 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1140
Query: 1141 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1198
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Sbjct: 1141 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1198
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo
sapiens]
Length = 1171
Score = 2351 bits (6092), Expect = 0.0
Identities = 1171/1198 (97%), Positives = 1171/1198 (97%), Gaps = 27/1198 (2%)
Query: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
Query: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
Query: 361 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
Sbjct: 361 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 420
Query: 421 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
Sbjct: 421 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 480
Query: 481 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
Sbjct: 481 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
Query: 541 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 600
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN
Sbjct: 541 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN------- 593
Query: 601 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 660
QPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
Sbjct: 594 --------------------QPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 633
Query: 661 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 720
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
Sbjct: 634 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 693
Query: 721 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 780
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
Sbjct: 694 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 753
Query: 781 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 840
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
Sbjct: 754 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 813
Query: 841 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 900
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
Sbjct: 814 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 873
Query: 901 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 960
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
Sbjct: 874 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 933
Query: 961 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 1020
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
Sbjct: 934 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 993
Query: 1021 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1080
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
Sbjct: 994 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1053
Query: 1081 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1140
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
Sbjct: 1054 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1113
Query: 1141 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1198
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Sbjct: 1114 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo
sapiens]
Length = 1210
Score = 1455 bits (3766), Expect = 0.0
Identities = 789/1257 (62%), Positives = 917/1257 (72%), Gaps = 113/1257 (8%)
Query: 8 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
MAS +QVFSP ++ SSAFCS KKLKIEPS WD++G S+ K Y+ SK +P +Q
Sbjct: 1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
Query: 68 STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124
++S V N ++P Y+Q ++ P + HIVVT+A SS S L RS VSLL+
Sbjct: 57 NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
Query: 125 TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184
YQKCGLKRKSEE+++ SVQIIEEHPP++ N + A ATT+T T+K+S S+ EGDY
Sbjct: 117 PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
Query: 185 QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244
QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 176 QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
Query: 245 SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304
SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 236 SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
Query: 305 LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364
LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 296 LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
Query: 365 RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 424
RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL
Sbjct: 356 RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 415
Query: 425 LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTD 484
LSAGTKTTRFFNRD + YPLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TD
Sbjct: 416 LSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTD 475
Query: 485 LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSC 544
LEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSC
Sbjct: 476 LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSC 535
Query: 545 FQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQA------PSS 598
FQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL TVHNQA ++
Sbjct: 536 FQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTA 595
Query: 599 TSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVC 658
+AT+SLAN +VS+LNY S LY SAA + VAQ+ + LQ GT QIC + DPFQQ IVC
Sbjct: 596 AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVC 655
Query: 659 PPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------- 704
PP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+L Q
Sbjct: 656 PPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714
Query: 705 --------------------------------QAWPSGTQQILLPPAWQQLTGVATHTSV 732
QAWP GTQQILLP WQQL GVA H SV
Sbjct: 715 QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSV 774
Query: 733 QHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMR 792
Q +IPE M QQLADWRN H+HG+ Y+ IMQQP+LLT HVTL AQPLNVGVAHV+R
Sbjct: 775 QPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVR 834
Query: 793 QQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACS 852
QQ +S+ S+K+KQ + V + S+ +V SQ S +V SSP +
Sbjct: 835 QQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRT 876
Query: 853 TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQR 912
TS S + Q Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+ K R
Sbjct: 877 TS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPR 930
Query: 913 KNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVP 970
NVIS VTV+DSP SDSS +SPYS + N+ + + G + TG RTIIVP
Sbjct: 931 SNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVP 988
Query: 971 PLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP 1030
PLKTQ + V + +S S + V S SG SSG YR QR G
Sbjct: 989 PLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT 1038
Query: 1031 HFQQQQPLNLSQAQQHI---TTDRTGSH---RRQQAYITPTMAQAPYSFPHNSPSHGTVH 1084
QPLNLSQ QQ T+ S+ RRQQA++ P ++QAPY+F H SP H T H
Sbjct: 1039 --SAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGH 1095
Query: 1085 PHLAAAAAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQGSARHTVQHTAYPASIV 1141
PHL A A AHLP+Q HLYTY AP AALGST ++AHL + QGS+RH +T +P+++V
Sbjct: 1096 PHL--APAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLV 1153
Query: 1142 HQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1198
HQVPVS+GP +L S ++ P+QY QFA Q+YI +S ST+YTGYPLSP K++QY Y+
Sbjct: 1154 HQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1210
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [Homo
sapiens]
Length = 1075
Score = 1286 bits (3329), Expect = 0.0
Identities = 700/1092 (64%), Positives = 800/1092 (73%), Gaps = 101/1092 (9%)
Query: 8 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
MAS +QVFSP ++ SSAFCS KKLKIEPS WD++G S+ K Y+ SK +P +Q
Sbjct: 1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
Query: 68 STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124
++S V N ++P Y+Q ++ P + HIVVT+A SS S L RS VSLL+
Sbjct: 57 NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
Query: 125 TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184
YQKCGLKRKSEE+++ SVQIIEEHPP++ N + A ATT+T T+K+S S+ EGDY
Sbjct: 117 PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
Query: 185 QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244
QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 176 QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
Query: 245 SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304
SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 236 SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
Query: 305 LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364
LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 296 LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
Query: 365 RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 424
RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL
Sbjct: 356 RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 415
Query: 425 LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTD 484
LSAGTKTTRFFNRD + YPLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TD
Sbjct: 416 LSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTD 475
Query: 485 LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSC 544
LEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSC
Sbjct: 476 LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSC 535
Query: 545 FQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQA------PSS 598
FQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL TVHNQA ++
Sbjct: 536 FQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTA 595
Query: 599 TSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVC 658
+AT+SLAN +VS+LNY S LY SAA + VAQ+ + LQ GT QIC + DPFQQ IVC
Sbjct: 596 AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVC 655
Query: 659 PPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------- 704
PP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+L Q
Sbjct: 656 PPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714
Query: 705 --------------------------------QAWPSGTQQILLPPAWQQLTGVATHTSV 732
QAWP GTQQILLP WQQL GVA H SV
Sbjct: 715 QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSV 774
Query: 733 QHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMR 792
Q +IPE M QQLADWRN H+HG+ Y+ IMQQP+LLT HVTL AQPLNVGVAHV+R
Sbjct: 775 QPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVR 834
Query: 793 QQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACS 852
QQ +S+ S+K+KQ + V + S+ +V SQ S +V SSP +
Sbjct: 835 QQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRT 876
Query: 853 TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQR 912
TS S + Q Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+ K R
Sbjct: 877 TS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPR 930
Query: 913 KNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVP 970
NVIS VTV+DSP SDSS +SPYS + N+ + + G + TG RTIIVP
Sbjct: 931 SNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVP 988
Query: 971 PLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP 1030
PLKTQ + V + +S S + V S SG SSG YR QR G
Sbjct: 989 PLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT 1038
Query: 1031 HFQQQQPLNLSQ 1042
QPLNLSQ
Sbjct: 1039 --SAAQPLNLSQ 1048
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2 [Homo
sapiens]
Length = 1194
Score = 1096 bits (2834), Expect = 0.0
Identities = 647/1267 (51%), Positives = 797/1267 (62%), Gaps = 149/1267 (11%)
Query: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
Query: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
Query: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
Query: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
Query: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
Query: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 352 SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411
Query: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
SQTQGLP E LL+ GTK+TRFF ++TD + WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 412 SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471
Query: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533
DD+A VN DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 472 DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531
Query: 534 DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593
DFPHS HVKSCF M+ICK +N DT N +KT + VA S++ LT F ++ T+ +
Sbjct: 532 DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590
Query: 594 QAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQ 652
QA ++ S +V +PLQ GTAQ C D FQ
Sbjct: 591 QALTT---------------------------SAHSVVHHGIPLQAGTAQFGCG--DAFQ 621
Query: 653 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ 712
Q LI+CPP QG+ A+ K YS+R++N VP+VTQAP QPLQI+PG+L+ Q W TQ
Sbjct: 622 QTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQ 680
Query: 713 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT 772
Q+L+ PAWQQ+T +A T+ T+ E++AG+ +L DW + +HYN +M QP LLT
Sbjct: 681 QMLV-PAWQQVTPLAPATT----TLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLT 734
Query: 773 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQ--R 830
+TL A QP++VG+AHV+ QP +T +++ + +S++N + A SP+
Sbjct: 735 NQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNI----PHSAFISPKIIN 790
Query: 831 SKRVK-----ENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTV 885
K V+ E + + + C TS+ + S+ ++QRQTI+I D+PSP V
Sbjct: 791 GKDVEEVSCIETQDNQNSEGEARNCCETSIR----QDSDSSVSDKQRQTIIIADSPSPAV 846
Query: 886 SVITISSDTDEEE-EQKH---------------------------APTSTVSK------- 910
SVITISSDTDEEE Q+H +P ST+S
Sbjct: 847 SVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSS 906
Query: 911 ----QRKNVI-------SCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENH 959
+R N + SC TV SP SDSS + SP++ + N + S +
Sbjct: 907 PSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENT-ELVSSADTE 965
Query: 960 CTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSG 1019
+++VPP++ + +N H ++ S + S +
Sbjct: 966 TKPAVCSVVVPPVELENG-----------LNADEHMANTDSICQPLIKGRSAPGRLNQPS 1014
Query: 1020 AITYRQQRPGPHFQQQQPLNLSQAQQ----HITTDRTGSHRRQQAYITPTMAQAPYSFPH 1075
A+ RQQ+ FQQQ LN SQ Q H + HRRQQAYI ++ P++ H
Sbjct: 1015 AVGTRQQKLTSAFQQQH-LNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSH 1073
Query: 1076 NSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTA 1135
SP+H VH HL A HL QP L Y + A L S VAHL+AS ++R +QH
Sbjct: 1074 GSPNHTAVHAHL---AGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPT 1130
Query: 1136 Y----PASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAK 1191
Y P+ IVHQVPV + PR+LPSPTIH +QY F +YI+ASPA YTG+PLSP K
Sbjct: 1131 YNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGFPLSPTK 1187
Query: 1192 VNQYPYI 1198
++QYPY+
Sbjct: 1188 LSQYPYM 1194
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1215
Score = 1088 bits (2813), Expect = 0.0
Identities = 649/1287 (50%), Positives = 796/1287 (61%), Gaps = 168/1287 (13%)
Query: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
Query: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
Query: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
Query: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
Query: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
Query: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 352 SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411
Query: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
SQTQGLP E LL+ GTK+TRFF ++TD + WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 412 SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471
Query: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533
DD+A VN DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 472 DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531
Query: 534 DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593
DFPHS HVKSCF M+ICK +N DT N +KT + VA S++ LT F ++ T+ +
Sbjct: 532 DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590
Query: 594 QAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQ 652
QA ++ S +V +PLQ GTAQ C D FQ
Sbjct: 591 QALTT---------------------------SAHSVVHHGIPLQAGTAQFGCG--DAFQ 621
Query: 653 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ 712
Q LI+CPP QG+ A+ K YS+R++N VP+VTQAP QPLQI+PG+L+ Q W TQ
Sbjct: 622 QTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQ 680
Query: 713 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT 772
Q+L+ PAWQQ+T +A T+ T+ E++AG+ +L DW + +HYN +M QP LLT
Sbjct: 681 QMLV-PAWQQVTPLAPATT----TLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLT 734
Query: 773 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCE-VSSSQAISSPQRS 831
+TL A QP++VG+AHV+ QP +T +K+KQ Q+ V E + I++ S
Sbjct: 735 NQITLSAPQPVSVGIAHVVWPQPATT---KKNKQCQNRGILVKLMEWEPGREEINAFSWS 791
Query: 832 KRVKENTPPRCAMV--------------------------HSSPACSTSVTCGWGDVASS 865
++ P A + + C TS+ + S
Sbjct: 792 NSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIR----QDSDS 847
Query: 866 TTRERQRQTIVIPDTPSPTVSVITISSDTDEEE-EQKH---------------------- 902
+ ++QRQTI+I D+PSP VSVITISSDTDEEE Q+H
Sbjct: 848 SVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDR 907
Query: 903 -----APTSTVSK-----------QRKNVI-------SCVTVHDSPYSDSSSNTSPYSVQ 939
+P ST+S +R N + SC TV SP SDSS + SP++
Sbjct: 908 MCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAES 967
Query: 940 QRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYK 999
+ N + S + +++VPP++ + +N H ++
Sbjct: 968 TFVEDTHENT-ELVSSADTETKPAVCSVVVPPVELENG-----------LNADEHMANTD 1015
Query: 1000 SKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQ----HITTDRTGSH 1055
S + S + A+ RQQ+ FQQQ LN SQ Q H + H
Sbjct: 1016 SICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQH-LNFSQVQHFGSGHQEWNGNFGH 1074
Query: 1056 RRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTG 1115
RRQQAYI ++ P++ H SP+H VH HL A HL QP L Y + A L S
Sbjct: 1075 RRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHL---AGNTHLGGQPTLLPYPSSATLSSAA 1131
Query: 1116 TVAHLVASQGSARHTVQHTAY----PASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQT 1171
VAHL+AS ++R +QH Y P+ IVHQVPV + PR+LPSPTIH +QY F +
Sbjct: 1132 PVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHS 1191
Query: 1172 YISASPASTVYTGYPLSPAKVNQYPYI 1198
YI+ASPA YTG+PLSP K++QYPY+
Sbjct: 1192 YIAASPA---YTGFPLSPTKLSQYPYM 1215
>gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [Homo
sapiens]
Length = 836
Score = 920 bits (2378), Expect = 0.0
Identities = 511/878 (58%), Positives = 602/878 (68%), Gaps = 105/878 (11%)
Query: 384 MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPY 443
MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRD + Y
Sbjct: 1 MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY 60
Query: 444 PLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDL 503
PLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TDLEG+DML EKADRRE+IDL
Sbjct: 61 PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL 120
Query: 504 LKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQ 563
LKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSCFQNMEICKRRV+MYDTV+Q
Sbjct: 121 LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ 180
Query: 564 SKTPFITHVAPSTSTNLTMTFNNQLTTVHNQA------PSSTSATISLANPEVSILNYPS 617
K+PF THVAP+TSTNLTM+F+NQL TVHNQA ++ +AT+SLAN +VS+LNY S
Sbjct: 181 IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS 240
Query: 618 TLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ-GLQASPSKHAGYS 676
LY SAA + VAQ+ + LQ GT QIC + DPFQQ IVCPP FQ GLQA+ +KH+G+
Sbjct: 241 ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFP 299
Query: 677 VRMENAVPIVTQAPGAQPLQIQPGLLAQ-------------------------------- 704
VRM+NAVPIV QAP AQPLQIQ G+L Q
Sbjct: 300 VRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAA 359
Query: 705 -------------QAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADW 751
QAWP GTQQILLP WQQL GVA H SVQ +IPE M QQLADW
Sbjct: 360 GRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADW 419
Query: 752 RNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSV 811
RN H+HG+ Y+ IMQQP+LLT HVTL AQPLNVGVAHV+RQQ +S+ S+K+KQ + V
Sbjct: 420 RNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQ-SAPV 478
Query: 812 RNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQ 871
+ S+ +V SQ S +V SSP +TS S + Q
Sbjct: 479 SSKSSLDVLPSQVYS-----------------LVGSSPLRTTS------SYNSLVPVQDQ 515
Query: 872 RQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSS 931
Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+ K R NVIS VTV+DSP SDSS
Sbjct: 516 HQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSL 575
Query: 932 NTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPV 989
+SPYS + N+ + + G + TG RTIIVPPLKTQ + V
Sbjct: 576 -SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVPPLKTQLGDCTV-------- 625
Query: 990 NTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI-- 1047
+ +S S + V S SG SSG YR QR G QPLNLSQ QQ
Sbjct: 626 --ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT--SAAQPLNLSQNQQSSAA 681
Query: 1048 -TTDRTGSH---RRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLY 1103
T+ S+ RRQQA++ P ++QAPY+F H SP H T HPHL A A AHLP+Q HLY
Sbjct: 682 PTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGHPHL--APAPAHLPSQAHLY 738
Query: 1104 TYTAP---AALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHP 1160
TY AP AALGST ++AHL + QGS+RH +T +P+++VHQVPVS+GP +L S ++ P
Sbjct: 739 TYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAP 798
Query: 1161 SQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1198
+QY QFA Q+YI +S ST+YTGYPLSP K++QY Y+
Sbjct: 799 AQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 836
>gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [Homo
sapiens]
Length = 816
Score = 865 bits (2234), Expect = 0.0
Identities = 486/853 (56%), Positives = 577/853 (67%), Gaps = 105/853 (12%)
Query: 409 QIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKY 468
QIRYISQTQGLPAEYLLSAGTKTTRFFNRD + YPLWRLKTP++HE ETGIKSKEARKY
Sbjct: 6 QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY 65
Query: 469 IFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
IFNCLDDMAQVNM+TDLEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVT
Sbjct: 66 IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 125
Query: 529 MTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQL 588
MTHLLDFPHS HVKSCFQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL
Sbjct: 126 MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL 185
Query: 589 TTVHNQA------PSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTA 642
TVHNQA ++ +AT+SLAN +VS+LNY S LY SAA + VAQ+ + LQ GT
Sbjct: 186 NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT 245
Query: 643 QICARPDPFQQALIVCPPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGL 701
QIC + DPFQQ IVCPP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+
Sbjct: 246 QICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGV 304
Query: 702 LAQ---------------------------------------------QAWPSGTQQILL 716
L Q QAWP GTQQILL
Sbjct: 305 LTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILL 364
Query: 717 PPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVT 776
P WQQL GVA H SVQ +IPE M QQLADWRN H+HG+ Y+ IMQQP+LLT HVT
Sbjct: 365 PSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVT 424
Query: 777 LPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKE 836
L AQPLNVGVAHV+RQQ +S+ S+K+KQ + V + S+ +V SQ S
Sbjct: 425 LATAQPLNVGVAHVVRQQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS---------- 473
Query: 837 NTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDE 896
+V SSP +TS S + Q Q I+IPDTPSP VSVITI SDTDE
Sbjct: 474 -------LVGSSPLRTTS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE 520
Query: 897 EEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKG 954
EE+ K+ P+S+ K R NVIS VTV+DSP SDSS +SPYS + N+ + + G
Sbjct: 521 EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPG 579
Query: 955 SLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSS 1014
+ TG RTIIVPPLKTQ + V + +S S + V S SG SS
Sbjct: 580 RVVADGTGT-RTIIVPPLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSS 628
Query: 1015 GSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI---TTDRTGSH---RRQQAYITPTMAQ 1068
G YR QR G QPLNLSQ QQ T+ S+ RRQQA++ P ++Q
Sbjct: 629 GCCITPTGYRAQRGGT--SAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQ 685
Query: 1069 APYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQG 1125
APY+F H SP H T HPHL A A AHLP+Q HLYTY AP AALGST ++AHL + QG
Sbjct: 686 APYTFQHGSPLHSTGHPHL--APAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQG 743
Query: 1126 SARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGY 1185
S+RH +T +P+++VHQVPVS+GP +L S ++ P+QY QFA Q+YI +S ST+YTGY
Sbjct: 744 SSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGY 803
Query: 1186 PLSPAKVNQYPYI 1198
PLSP K++QY Y+
Sbjct: 804 PLSPTKISQYSYL 816
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 736 bits (1901), Expect = 0.0
Identities = 368/368 (100%), Positives = 368/368 (100%)
Query: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
Sbjct: 1 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 60
Query: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
Sbjct: 61 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 120
Query: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
Sbjct: 121 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 180
Query: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
Sbjct: 241 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 300
Query: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
Sbjct: 301 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 360
Query: 361 YLQSRYYR 368
YLQSRYYR
Sbjct: 361 YLQSRYYR 368
>gi|169171552 PREDICTED: similar to homeodomain interacting protein
kinase 3 [Homo sapiens]
Length = 264
Score = 502 bits (1293), Expect = e-142
Identities = 252/252 (100%), Positives = 252/252 (100%)
Query: 8 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV
Sbjct: 1 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 60
Query: 68 STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ 127
STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ
Sbjct: 61 STSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQ 120
Query: 128 KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV 187
KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
Sbjct: 121 KCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV 180
Query: 188 QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL 247
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL
Sbjct: 181 QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL 240
Query: 248 ARLSTESADDYN 259
ARLSTESADDYN
Sbjct: 241 ARLSTESADDYN 252
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 335 bits (858), Expect = 2e-91
Identities = 178/356 (50%), Positives = 237/356 (66%), Gaps = 10/356 (2%)
Query: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253
S T+ Y+++E LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
Query: 254 SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALM 313
++ + +R E F LVFE+LEQNL++F K+N F+PLP ++IR V QV TAL
Sbjct: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
Query: 314 KLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 371
+LK L +IHADLKPENIMLVD +R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
Query: 372 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 431
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP +LL A K
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
Query: 432 TRFFNRD--TDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN-----MTTD 484
FF R+ D+ P W+LK+ D+ AET ++ E RKY+ LD + VN
Sbjct: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304
Query: 485 LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
+ L E AD + ++L+K+MLT ++ +RI+P L HPFV+M L +TH
Sbjct: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 222 bits (565), Expect = 2e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
+ D W LK D + E K RK + N L + T G E
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
AD +F DL+ +ML D RI P L H F T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 222 bits (565), Expect = 2e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
+ D W LK D + E K RK + N L + T G E
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
AD +F DL+ +ML D RI P L H F T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 222 bits (565), Expect = 2e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
+ D W LK D + E K RK + N L + T G E
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
AD +F DL+ +ML D RI P L H F T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
Score = 30.8 bits (68), Expect = 8.1
Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 5/97 (5%)
Query: 942 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 998
+GH A+ K + +P+T I P Q S D NTS+ S +
Sbjct: 442 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499
Query: 999 KSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQ 1035
+ SS TS++ SSG SSG + R P Q +
Sbjct: 500 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHR 536
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 222 bits (565), Expect = 2e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
+ D W LK D + E K RK + N L + T G E
Sbjct: 387 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434
Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
AD +F DL+ +ML D RI P L H F T
Sbjct: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473
Score = 30.8 bits (68), Expect = 8.1
Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)
Query: 942 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 998
+GH A+ K + +P+T I P Q S D NTS+ S +
Sbjct: 433 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 490
Query: 999 KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1033
+ SS TS++ SSG SSG T++ + G HF +
Sbjct: 491 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 550
Query: 1034 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1091
QQ P L + T T +H Q+ Q H NS H H H
Sbjct: 551 QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 610
Query: 1092 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1145
L + Y +P ST G H + S S+ T + +S +Q
Sbjct: 611 GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 668
Query: 1146 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1196
+ R + + T+ Q A + T S T G+P N P
Sbjct: 669 QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 719
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 222 bits (565), Expect = 2e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
+ D W LK D + E K RK + N L + T G E
Sbjct: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
Query: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
AD +F DL+ +ML D RI P L H F T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
Score = 30.8 bits (68), Expect = 8.1
Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)
Query: 942 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 998
+GH A+ K + +P+T I P Q S D NTS+ S +
Sbjct: 442 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499
Query: 999 KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1033
+ SS TS++ SSG SSG T++ + G HF +
Sbjct: 500 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 559
Query: 1034 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1091
QQ P L + T T +H Q+ Q H NS H H H
Sbjct: 560 QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 619
Query: 1092 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1145
L + Y +P ST G H + S S+ T + +S +Q
Sbjct: 620 GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 677
Query: 1146 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1196
+ R + + T+ Q A + T S T G+P N P
Sbjct: 678 QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 728
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 210 bits (535), Expect = 6e-54
Identities = 122/336 (36%), Positives = 183/336 (54%), Gaps = 16/336 (4%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 436 NRDTDSPYPLWRLK-TPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK 494
R + L R K D++ + +E Q +
Sbjct: 348 ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG---------VQTGGPGGRRAGEPGHSP 398
Query: 495 ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
AD F DL+ +ML + RI+P+ L H F T
Sbjct: 399 ADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 209 bits (533), Expect = 1e-53
Identities = 124/335 (37%), Positives = 183/335 (54%), Gaps = 42/335 (12%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKA 495
R P W L+ ++KE RK D +G
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371
Query: 496 DRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
RR DL+ +ML + RI+P+ L H F T
Sbjct: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 207 bits (528), Expect = 4e-53
Identities = 127/356 (35%), Positives = 184/356 (51%), Gaps = 37/356 (10%)
Query: 173 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 232
SK S + G Y V H+ + YEVLE +G+G+FGQV KC NE+VA+KI++N
Sbjct: 81 SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
Query: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQN 291
+ +Q +E+ IL L + D+ YN V + F +NH C+ FE+L NLY+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
Query: 292 KFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS 351
F L +R V L L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSC 255
Query: 352 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 411
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG +E +Q+
Sbjct: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
Query: 412 YISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFN 471
I + GLP + ++ FF D I + +K +
Sbjct: 315 CIMEVLGLPPAGFIQTASRRQTFF----------------DSKGFPKNITNNRGKKR-YP 357
Query: 472 CLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV 527
D+ V T D F+D L++ L + R+TP + L H ++
Sbjct: 358 DSKDLTMVLKTYD-------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 204 bits (520), Expect = 3e-52
Identities = 120/335 (35%), Positives = 178/335 (53%), Gaps = 54/335 (16%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
Query: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKA 495
R P W L+ ++KE RK
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRK---------------------------- 365
Query: 496 DRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
DL+ +ML + RI+P+ L H F T
Sbjct: 366 ------DLVLRMLEYEPAARISPLGALQHGFFRRT 394
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 204 bits (518), Expect = 5e-52
Identities = 126/362 (34%), Positives = 189/362 (52%), Gaps = 25/362 (6%)
Query: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
T N G + +G Y V H+ + YEVL+ +G+G+FGQVVK + ++ VA+K
Sbjct: 195 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 251
Query: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
+++N + RQ E+ IL L + D+ N + E F +NH C+ FE+L NLY+
Sbjct: 252 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 311
Query: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
+K+NKF L +R + L L +IH DLKPENI+L R +KVIDF
Sbjct: 312 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 369
Query: 348 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 407
GS+ + + V TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E
Sbjct: 370 GSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEG 428
Query: 408 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT--PDDHEAETGIKSKEA 465
DQ+ + + G+P++ LL A + F + YP + T D G +S+
Sbjct: 429 DQLACMIELLGMPSQKLLDASKRAKNFV---SSKGYPRYCTVTTLSDGSVVLNGGRSRRG 485
Query: 466 RKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHP 525
+ + + ++ D F+D LK+ L D R+TP + L HP
Sbjct: 486 K------------LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHP 533
Query: 526 FV 527
++
Sbjct: 534 WL 535
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 204 bits (518), Expect = 5e-52
Identities = 126/362 (34%), Positives = 189/362 (52%), Gaps = 25/362 (6%)
Query: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
T N G + +G Y V H+ + YEVL+ +G+G+FGQVVK + ++ VA+K
Sbjct: 122 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 178
Query: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
+++N + RQ E+ IL L + D+ N + E F +NH C+ FE+L NLY+
Sbjct: 179 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 238
Query: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
+K+NKF L +R + L L +IH DLKPENI+L R +KVIDF
Sbjct: 239 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 296
Query: 348 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 407
GS+ + + V TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E
Sbjct: 297 GSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEG 355
Query: 408 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT--PDDHEAETGIKSKEA 465
DQ+ + + G+P++ LL A + F + YP + T D G +S+
Sbjct: 356 DQLACMIELLGMPSQKLLDASKRAKNFV---SSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
Query: 466 RKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHP 525
+ + + ++ D F+D LK+ L D R+TP + L HP
Sbjct: 413 K------------LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHP 460
Query: 526 FV 527
++
Sbjct: 461 WL 462
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 194 bits (494), Expect = 3e-49
Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)
Query: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
N+G + D + H + YEVL+ +G+G+FGQV + + + VA+K+++N
Sbjct: 166 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 224
Query: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
+ RQ E+ IL L + N + E F +NH C+ FE+L +LY+ +K+NKF
Sbjct: 225 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 284
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
++ +R Q + +L L +IH DLKPENI+L R KVIDFGS+
Sbjct: 285 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 342
Query: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
+ + TY+QSR+YRAPEIILG + ID+WS GC++AEL G PL+PG E DQ+ +
Sbjct: 343 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 401
Query: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
+ G+P LL +K ++F P D G +S+ +K
Sbjct: 402 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 455
Query: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
+ T L+G D + FI+ LK+ L D R+TP + L HP+++
Sbjct: 456 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 503
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 194 bits (494), Expect = 3e-49
Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)
Query: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
N+G + D + H + YEVL+ +G+G+FGQV + + + VA+K+++N
Sbjct: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244
Query: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
+ RQ E+ IL L + N + E F +NH C+ FE+L +LY+ +K+NKF
Sbjct: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304
Query: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
++ +R Q + +L L +IH DLKPENI+L R KVIDFGS+
Sbjct: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 362
Query: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
+ + TY+QSR+YRAPEIILG + ID+WS GC++AEL G PL+PG E DQ+ +
Sbjct: 363 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
Query: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
+ G+P LL +K ++F P D G +S+ +K
Sbjct: 422 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 475
Query: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
+ T L+G D + FI+ LK+ L D R+TP + L HP+++
Sbjct: 476 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 171 bits (434), Expect = 3e-42
Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)
Query: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
YE+++ LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T +
Sbjct: 203 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 262
Query: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
+ V+ E F+H H C+VFE+L + YDF+K+N F P L +IR + Q+ ++ L
Sbjct: 263 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 322
Query: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
S L H DLKPENI+ V + Y +KV+DFGSA++ + ST
Sbjct: 323 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 381
Query: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 382 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 441
Query: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
++++ T+ ++F+ D W D+H + A +Y+ + + +
Sbjct: 442 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 483
Query: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
+ D+E DL++KML D KRIT E L HPF
Sbjct: 484 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 518
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 171 bits (434), Expect = 3e-42
Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)
Query: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
YE+++ LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T +
Sbjct: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
Query: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
+ V+ E F+H H C+VFE+L + YDF+K+N F P L +IR + Q+ ++ L
Sbjct: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
Query: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
S L H DLKPENI+ V + Y +KV+DFGSA++ + ST
Sbjct: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
Query: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
Query: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
++++ T+ ++F+ D W D+H + A +Y+ + + +
Sbjct: 400 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 441
Query: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
+ D+E DL++KML D KRIT E L HPF
Sbjct: 442 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 476
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 169 bits (427), Expect = 2e-41
Identities = 117/359 (32%), Positives = 189/359 (52%), Gaps = 25/359 (6%)
Query: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 232
+++ +++EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
Query: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ- 290
+ + G E+ L +L+ DD ++ +R + F HK H CLVFE L NL + LK+
Sbjct: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
Query: 291 NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA 350
K L +K +R QQ+ AL LK ++HAD+KP+NI LV+ S+ +K+ DFGSA
Sbjct: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKTI--LKLCDFGSA 838
Query: 351 SHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI 410
SHV+ + YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG + +
Sbjct: 839 SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898
Query: 411 RYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIF 470
+ +G ++ G + F+++ + Y + + E T + + K
Sbjct: 899 KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY--IEVDKVTEREKVTVMSTINPTK--- 953
Query: 471 NCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFV 527
++ DL G L E ++ + DLL ++L +D KRI+ + L H F+
Sbjct: 954 ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 166 bits (420), Expect = 1e-40
Identities = 104/345 (30%), Positives = 174/345 (50%), Gaps = 46/345 (13%)
Query: 199 YEVLEFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-STESAD 256
YE+++ LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST+
Sbjct: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
Query: 257 DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
+ V+ E F H H C+VFE+L + YDF+K+N F P + +IR + Q+ ++ L
Sbjct: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
Query: 317 SLGLIHADLKPENIMLV---------------DPSRQPYRVKVIDFGSASHVSKAVCSTY 361
L H DLKPENI+ V + + + +KV+DFGSA++ + ST
Sbjct: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337
Query: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + + G
Sbjct: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397
Query: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
++++ K F + D W D+H + A +Y+ + +
Sbjct: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLKEF-- 437
Query: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
ML + + DL+++ML D +RIT E L HPF
Sbjct: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 157 bits (398), Expect = 4e-38
Identities = 111/382 (29%), Positives = 192/382 (50%), Gaps = 55/382 (14%)
Query: 165 TATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC--WKRGTN 222
+++ S+ +K+ ++EG L+ H V + YE++ LG GTFG+VV+C +RG
Sbjct: 131 SSSHSSRRAKSVEDDAEG--HLIYH-VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGA 187
Query: 223 EIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNF-VRAYECFQHKNHTCLVFEMLE 281
VA+KI+KN Y ++E+++L +++ + D+ N V+ ++ F + H C+ FE+L
Sbjct: 188 R-VALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG 246
Query: 282 QNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-------- 333
+ +DFLK N + P P+ +R + Q+ A+ L L H DLKPENI+ V
Sbjct: 247 LSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTY 306
Query: 334 -------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
+ S + V+V+DFGSA+ ST + +R+YRAPE+IL L + + D+WS
Sbjct: 307 NLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 365
Query: 387 LGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLW 446
+GC+I E ++G+ L+ + + + + G P + T+ ++F R
Sbjct: 366 IGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PIPSRMIRKTRKQKYFYRG-------- 416
Query: 447 RLKTPDDHEAETGIKS--KEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLL 504
RL ++ A ++ K R+Y+ + E + + DL+
Sbjct: 417 RLDWDENTSAGRYVRENCKPLRRYLTS---------------------EAEEHHQLFDLI 455
Query: 505 KKMLTIDADKRITPIETLNHPF 526
+ ML + KR+T E L HPF
Sbjct: 456 ESMLEYEPAKRLTLGEALQHPF 477
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 151 bits (381), Expect = 4e-36
Identities = 108/385 (28%), Positives = 186/385 (48%), Gaps = 55/385 (14%)
Query: 164 ATATTSTATSKNSGSNSEGDYQLVQHEVLCS----MTNTYEVLEFLGRGTFGQVVKCWK- 218
+ ++ S +SK S + E D + ++C + YE++ LG GTFG+VV+C
Sbjct: 268 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 324
Query: 219 -RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLV 276
RG ++ VA+KI++N Y ++E+++L ++ + ++ + V + F H C+
Sbjct: 325 ARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIA 383
Query: 277 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV--- 333
FE+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V
Sbjct: 384 FELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSE 443
Query: 334 ------------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEA 381
+ S + ++V DFGSA+ +T + +R+YR PE+IL L + +
Sbjct: 444 FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQP 502
Query: 382 IDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 441
D+WS+GC++ E + G+ L+ + + + + G +++ K F+
Sbjct: 503 CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL-- 560
Query: 442 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFI 501
+W D + G KE K + S ML + + +
Sbjct: 561 ---VW------DENSSDGRYVKENCKPL-----------------KSYMLQDSLEHVQLF 594
Query: 502 DLLKKMLTIDADKRITPIETLNHPF 526
DL+++ML D +RIT E L HPF
Sbjct: 595 DLMRRMLEFDPAQRITLAEALLHPF 619
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.126 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,856,734
Number of Sequences: 37866
Number of extensions: 2277118
Number of successful extensions: 13142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 427
Number of HSP's successfully gapped in prelim test: 504
Number of HSP's that attempted gapping in prelim test: 9827
Number of HSP's gapped (non-prelim): 2401
length of query: 1198
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1084
effective length of database: 13,930,794
effective search space: 15100980696
effective search space used: 15100980696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.