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Search of human proteins with 163310763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|163310763 serine/threonine kinase 32A isoform 1 [Homo
sapiens]
(396 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens] 814 0.0
gi|8923754 serine/threonine kinase 32B [Homo sapiens] 556 e-158
gi|32455269 serine/threonine kinase 32C [Homo sapiens] 516 e-146
gi|21450709 serine/threonine kinase 32A isoform 2 [Homo sapiens] 326 3e-89
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 196 2e-50
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 196 4e-50
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 196 4e-50
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 196 4e-50
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 195 5e-50
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 195 5e-50
gi|133908623 protein kinase C, iota [Homo sapiens] 192 4e-49
gi|4502023 AKT2 kinase [Homo sapiens] 191 8e-49
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 191 8e-49
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 191 1e-48
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 191 1e-48
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 191 1e-48
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 191 1e-48
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 191 1e-48
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 191 1e-48
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 191 1e-48
gi|62241015 AKT1 kinase [Homo sapiens] 185 5e-47
gi|62241013 AKT1 kinase [Homo sapiens] 185 5e-47
gi|62241011 AKT1 kinase [Homo sapiens] 185 5e-47
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 185 5e-47
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 185 5e-47
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 185 7e-47
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 185 7e-47
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 184 2e-46
gi|5453976 protein kinase C, theta [Homo sapiens] 183 2e-46
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 183 2e-46
>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
Length = 396
Score = 814 bits (2102), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV
Sbjct: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
Query: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE
Sbjct: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
Query: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM 180
ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM
Sbjct: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM 180
Query: 181 AGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFET 240
AGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFET
Sbjct: 181 AGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFET 240
Query: 241 TVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
TVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIP
Sbjct: 241 TVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
Query: 301 NKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQTCLLQEHLDSVQKEFI 360
NKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQTCLLQEHLDSVQKEFI
Sbjct: 301 NKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQTCLLQEHLDSVQKEFI 360
Query: 361 IFNREKVNRDFNKRQPNLALEQTKDPQGEDGQNNNL 396
IFNREKVNRDFNKRQPNLALEQTKDPQGEDGQNNNL
Sbjct: 361 IFNREKVNRDFNKRQPNLALEQTKDPQGEDGQNNNL 396
>gi|8923754 serine/threonine kinase 32B [Homo sapiens]
Length = 414
Score = 556 bits (1432), Expect = e-158
Identities = 277/403 (68%), Positives = 320/403 (79%), Gaps = 7/403 (1%)
Query: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
MG N S KPPVFDENE+VNFDHF+ILRAIGKGSFGKVCIVQK DTKKMYAMKYMNKQKC+
Sbjct: 1 MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI 60
Query: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
ER+EVRNVF+ELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHF E
Sbjct: 61 ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE 120
Query: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM 180
TVKL+ICEL +AL+YLQ IIHRD+KPDNILLDEHGHVHITDFNIA ++ + ++M
Sbjct: 121 GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSM 180
Query: 181 AGTKPYMAPEMFS--SRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTF 238
AGTKPYMAPE+F +G GYS+ VDWWSLG+TAYELLRG RPY I S T EI++ F
Sbjct: 181 AGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMF 240
Query: 239 ETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGF 298
+ V Y S W + MV+LL+KLL +P+ R S L D+Q+ PY+ D+NWDAVF+K L+PGF
Sbjct: 241 KVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGF 300
Query: 299 IPNKGRLNCDPTFELEEMILESKPLHKKKKRLAK-KEKDMRKCDSSQTCLLQEHLDSVQK 357
+PNKGRLNCDPTFELEEMILESKPLHKKKKRLAK + +D K LQ L++V++
Sbjct: 301 VPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVRE 360
Query: 358 EFIIFNREKVNRDFNKRQPNLALEQTKDPQG----EDGQNNNL 396
EFIIFNREK+ R + L + Q +DG NNNL
Sbjct: 361 EFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNL 403
>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
Length = 486
Score = 516 bits (1328), Expect = e-146
Identities = 256/394 (64%), Positives = 308/394 (78%), Gaps = 10/394 (2%)
Query: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
M A T+R+P VFD+ EDVNFDHF+ILRAIGKGSFGKVCIVQK DT+KMYAMKYMNKQ+C+
Sbjct: 72 MSAATARRP-VFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCI 130
Query: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
ER+EVRNVF+EL+I+Q +EH FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV F E
Sbjct: 131 ERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSE 190
Query: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM 180
+TV+L+ICE+ +ALDYL+ Q IIHRD+KPDNILLDE GH H+TDFNIA ++ + T +
Sbjct: 191 DTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATAL 250
Query: 181 AGTKPYMAPEMFSS--RKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTF 238
AGTKPYMAPE+F S G GYSF VDWWS+GV AYELLRG RPY I SS + + +V F
Sbjct: 251 AGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLF 310
Query: 239 ETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGF 298
T V Y WS+EMV+LL+KLL NP+ R S L DVQ P + + WD + +KR+ PGF
Sbjct: 311 STVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGF 370
Query: 299 IPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQT--CLLQEHLDSVQ 356
+PNKGRL+CDPTFELEEMILES+PLHKKKKRLAK + DSSQ+ LQ+ LD++Q
Sbjct: 371 VPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQ 430
Query: 357 KEFIIFNREKVNRDFNKRQPNLALEQTKDPQGED 390
++F+IFNREK+ KR +L E P+ D
Sbjct: 431 QDFVIFNREKL-----KRSQDLPREPLPAPESRD 459
>gi|21450709 serine/threonine kinase 32A isoform 2 [Homo sapiens]
Length = 166
Score = 326 bits (835), Expect = 3e-89
Identities = 157/157 (100%), Positives = 157/157 (100%)
Query: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV
Sbjct: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
Query: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE
Sbjct: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
Query: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEH 157
ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEH
Sbjct: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEH 157
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 196 bits (499), Expect = 2e-50
Identities = 109/302 (36%), Positives = 174/302 (57%), Gaps = 15/302 (4%)
Query: 11 VFDENEDVNFDHFEILRAIGKGSFGKVCIVQK---NDTKKMYAMKYMNKQKCVERNEVRN 67
V + +E + FE+L+ +G+GSFGKV +V+K +D +++YAMK + K R+ VR
Sbjct: 56 VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRT 115
Query: 68 VFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFI 127
E I+ + HPF+V L Y+FQ E +++++D L GGDL L + V F EE VK ++
Sbjct: 116 KM-ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 174
Query: 128 CELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPY 186
EL +ALD+L + II+RD+KP+NILLDE GH+ +TDF ++ + E + + GT Y
Sbjct: 175 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEY 234
Query: 187 MAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYP 246
MAPE+ + R G++ + DWWS GV +E+L G P+ KE + + P
Sbjct: 235 MAPEVVNRR---GHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKETMTMILKAKLGMP 288
Query: 247 SAWSQEMVSLLKKLLEPNPDQRFSQ----LSDVQNFPYMNDINWDAVFQKRLIPGFIPNK 302
S E SLL+ L + NP R + +++ + + I+W+ ++++ + P F P
Sbjct: 289 QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT 348
Query: 303 GR 304
GR
Sbjct: 349 GR 350
Score = 102 bits (253), Expect = 8e-22
Identities = 83/285 (29%), Positives = 141/285 (49%), Gaps = 25/285 (8%)
Query: 21 DHFEILRAIGKGSFG--KVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 78
D +E+ IG GS+ K CI + T +A+K ++K K E+ E+ + G
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKA--TNMEFAVKIIDKSKRDPTEEI-----EILLRYG- 471
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 138
+HP ++ L + D + +++V +L+ GG+L + + F E + + ++YL
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
Query: 139 NQRIIHRDMKPDNIL-LDEHGH---VHITDFNIAAMLPRET-QITTMAGTKPYMAPEMFS 193
Q ++HRD+KP NIL +DE G+ + I DF A L E + T T ++APE+
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL- 590
Query: 194 SRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVT----YPSAW 249
K GY A D WSLGV Y +L G P+ + +EI+ + + Y ++
Sbjct: 591 --KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSV 648
Query: 250 SQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRL 294
S L+ K+L +P QR + + V P++ ++WD + Q +L
Sbjct: 649 SDTAKDLVSKMLHVDPHQRLT-AALVLRHPWI--VHWDQLPQYQL 690
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 196 bits (497), Expect = 4e-50
Identities = 102/284 (35%), Positives = 171/284 (60%), Gaps = 12/284 (4%)
Query: 21 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 80
D FE LR +G GSFG+V +V+ +T YAMK +NKQK V+ +V ++ E +I+Q ++
Sbjct: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 140
PFLV L +SF+D +++V++ + GG++ LQ+ F E + ++V+A+ YL +
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
Query: 141 RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGY 200
+IHRD+KP+N+L+D+ G++ +TDF A + T T+ GT Y+APE+ S+ GY
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSK---GY 216
Query: 201 SFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKL 260
+ AVDWW+LGV YE+ G P++ + +I + V +PS S ++ LL+ L
Sbjct: 217 NKAVDWWALGVLIYEMAVGFPPFY---ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSL 273
Query: 261 LEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIP 300
L+ + +RF L D++N + +W A+++K++ FIP
Sbjct: 274 LQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIP 317
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 196 bits (497), Expect = 4e-50
Identities = 112/308 (36%), Positives = 175/308 (56%), Gaps = 19/308 (6%)
Query: 16 EDVNFDHFEILRAIGKGSFGKVCIVQK---NDTKKMYAMKYMNKQKCVERNEVRNVFKEL 72
E + FE+L+ +G+GS+GKV +V+K +D ++YAMK + K R+ VR+ E
Sbjct: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ER 118
Query: 73 QIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVM 132
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V F EE VK ++ EL +
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 133 ALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPEM 191
ALD+L + II+RD+KP+NILLDE GH+ ITDF ++ + + + + GT YMAPE+
Sbjct: 179 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 238
Query: 192 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 251
+ R G++ + DWWS GV +E+L G P+ KE + + P S
Sbjct: 239 VNRR---GHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKETMALILKAKLGMPQFLSG 292
Query: 252 EMVSLLKKLLEPNPDQRFSQ----LSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGR--- 304
E SLL+ L + NP R + +++ P+ I+W+ +++K + P F P GR
Sbjct: 293 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 352
Query: 305 -LNCDPTF 311
+ DP F
Sbjct: 353 TFHFDPEF 360
Score = 104 bits (260), Expect = 1e-22
Identities = 77/263 (29%), Positives = 129/263 (49%), Gaps = 22/263 (8%)
Query: 21 DHFEILRAIGKGSFG--KVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 78
D +EI IG GS+ K C+ + DT+ YA+K ++K K E+ E+ + G
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTE--YAVKIIDKSKRDPSEEI-----EILLRYG- 472
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 138
+HP ++ L + D + +++V++L+ GG+L + + +F E +C + +DYL
Sbjct: 473 QHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLH 532
Query: 139 NQRIIHRDMKPDNILL-DEHG---HVHITDFNIAAML-PRETQITTMAGTKPYMAPEMFS 193
+Q ++HRD+KP NIL DE G + + DF A L + T T ++APE+
Sbjct: 533 SQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL- 591
Query: 194 SRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSA-W--- 249
K GY A D WSLG+ Y +L G P+ + +EI+ + W
Sbjct: 592 --KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSI 649
Query: 250 SQEMVSLLKKLLEPNPDQRFSQL 272
S ++ K+L +P QR + +
Sbjct: 650 SDAAKDVVSKMLHVDPHQRLTAM 672
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 196 bits (497), Expect = 4e-50
Identities = 112/308 (36%), Positives = 175/308 (56%), Gaps = 19/308 (6%)
Query: 16 EDVNFDHFEILRAIGKGSFGKVCIVQK---NDTKKMYAMKYMNKQKCVERNEVRNVFKEL 72
E + FE+L+ +G+GS+GKV +V+K +D ++YAMK + K R+ VR+ E
Sbjct: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ER 110
Query: 73 QIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVM 132
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V F EE VK ++ EL +
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170
Query: 133 ALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPEM 191
ALD+L + II+RD+KP+NILLDE GH+ ITDF ++ + + + + GT YMAPE+
Sbjct: 171 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 230
Query: 192 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 251
+ R G++ + DWWS GV +E+L G P+ KE + + P S
Sbjct: 231 VNRR---GHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKETMALILKAKLGMPQFLSG 284
Query: 252 EMVSLLKKLLEPNPDQRFSQ----LSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGR--- 304
E SLL+ L + NP R + +++ P+ I+W+ +++K + P F P GR
Sbjct: 285 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 344
Query: 305 -LNCDPTF 311
+ DP F
Sbjct: 345 TFHFDPEF 352
Score = 104 bits (260), Expect = 1e-22
Identities = 77/263 (29%), Positives = 129/263 (49%), Gaps = 22/263 (8%)
Query: 21 DHFEILRAIGKGSFG--KVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 78
D +EI IG GS+ K C+ + DT+ YA+K ++K K E+ E+ + G
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTE--YAVKIIDKSKRDPSEEI-----EILLRYG- 464
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 138
+HP ++ L + D + +++V++L+ GG+L + + +F E +C + +DYL
Sbjct: 465 QHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLH 524
Query: 139 NQRIIHRDMKPDNILL-DEHG---HVHITDFNIAAML-PRETQITTMAGTKPYMAPEMFS 193
+Q ++HRD+KP NIL DE G + + DF A L + T T ++APE+
Sbjct: 525 SQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL- 583
Query: 194 SRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSA-W--- 249
K GY A D WSLG+ Y +L G P+ + +EI+ + W
Sbjct: 584 --KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSI 641
Query: 250 SQEMVSLLKKLLEPNPDQRFSQL 272
S ++ K+L +P QR + +
Sbjct: 642 SDAAKDVVSKMLHVDPHQRLTAM 664
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 195 bits (496), Expect = 5e-50
Identities = 97/286 (33%), Positives = 173/286 (60%), Gaps = 12/286 (4%)
Query: 19 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 78
+ D FE ++ +G GSFG+V +V+ +T YAMK ++KQK V+ ++ + E +I+Q +
Sbjct: 32 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 91
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 138
PFLV L +SF+D +++MV++ + GG++ HL++ F E + + ++V+ +YL
Sbjct: 92 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 151
Query: 139 NQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGA 198
+ +I+RD+KP+N+L+D+ G++ +TDF A + T T+ GT Y+APE+ S+
Sbjct: 152 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSK--- 206
Query: 199 GYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLK 258
GY+ AVDWW+LGV YE+ G P+ + +I + V +PS +S ++ LL+
Sbjct: 207 GYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 263
Query: 259 KLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIP 300
LL+ + +RF L +D++N + +W A++Q+++ FIP
Sbjct: 264 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 309
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 195 bits (496), Expect = 5e-50
Identities = 97/286 (33%), Positives = 173/286 (60%), Gaps = 12/286 (4%)
Query: 19 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 78
+ D FE ++ +G GSFG+V +V+ +T YAMK ++KQK V+ ++ + E +I+Q +
Sbjct: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 99
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 138
PFLV L +SF+D +++MV++ + GG++ HL++ F E + + ++V+ +YL
Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
Query: 139 NQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGA 198
+ +I+RD+KP+N+L+D+ G++ +TDF A + T T+ GT Y+APE+ S+
Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSK--- 214
Query: 199 GYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLK 258
GY+ AVDWW+LGV YE+ G P+ + +I + V +PS +S ++ LL+
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query: 259 KLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIP 300
LL+ + +RF L +D++N + +W A++Q+++ FIP
Sbjct: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 192 bits (488), Expect = 4e-49
Identities = 101/301 (33%), Positives = 170/301 (56%), Gaps = 18/301 (5%)
Query: 15 NEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQI 74
+ + F++LR IG+GS+ KV +V+ T ++YAMK + K+ + ++ V E +
Sbjct: 246 SSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHV 305
Query: 75 M-QGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMA 133
Q HPFLV L FQ E +F V++ + GGDL +H+Q+ EE + + E+ +A
Sbjct: 306 FEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 365
Query: 134 LDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIA--AMLPRETQITTMAGTKPYMAPEM 191
L+YL + II+RD+K DN+LLD GH+ +TD+ + + P +T +T GT Y+APE+
Sbjct: 366 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDT-TSTFCGTPNYIAPEI 424
Query: 192 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKE------IVHTFETTVVTY 245
+G Y F+VDWW+LGV +E++ GR P+ I S+ + + + +
Sbjct: 425 L---RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRI 481
Query: 246 PSAWSQEMVSLLKKLLEPNPDQRF-----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
P + S + S+LK L +P +R + +D+Q P+ +++WD + QK+++P F P
Sbjct: 482 PRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKP 541
Query: 301 N 301
N
Sbjct: 542 N 542
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 191 bits (486), Expect = 8e-49
Identities = 102/288 (35%), Positives = 163/288 (56%), Gaps = 11/288 (3%)
Query: 18 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 77
V + F+ L+ +GKG+FGKV +V++ T + YAMK + K+ + ++EV + E +++Q
Sbjct: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206
Query: 78 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 137
HPFL L Y+FQ + + V++ GG+L +HL + F EE + + E+V AL+YL
Sbjct: 207 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYL 266
Query: 138 QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRETQITTMAGTKPYMAPEMFSSRK 196
++ +++RD+K +N++LD+ GH+ ITDF + + + T GT Y+APE+
Sbjct: 267 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN- 325
Query: 197 GAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSL 256
Y AVDWW LGV YE++ GR P++ + E++ E + +P S E SL
Sbjct: 326 --DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEE---IRFPRTLSPEAKSL 380
Query: 257 LKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
L LL+ +P QR S +V + INW V QK+L+P F P
Sbjct: 381 LAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 191 bits (486), Expect = 8e-49
Identities = 103/306 (33%), Positives = 173/306 (56%), Gaps = 10/306 (3%)
Query: 15 NEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE--- 71
N + + F + R IG+G FG+V +K DT KMYAMK ++K++ + E
Sbjct: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
Query: 72 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 131
L ++ + PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E ++ + E++
Sbjct: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302
Query: 132 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 191
+ L+++ N+ +++RD+KP NILLDEHGHV I+D +A ++ ++ GT YMAPE+
Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV-GTHGYMAPEV 361
Query: 192 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 251
+KG Y + DW+SLG ++LLRG P+ + EI T V P ++S
Sbjct: 362 L--QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419
Query: 252 EMVSLLKKLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNC 307
E+ SLL+ LL+ + ++R L +V+ P+ ++W VF ++ P IP +G +N
Sbjct: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNA 479
Query: 308 DPTFEL 313
F++
Sbjct: 480 ADAFDI 485
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 191 bits (485), Expect = 1e-48
Identities = 105/288 (36%), Positives = 167/288 (57%), Gaps = 13/288 (4%)
Query: 23 FEILRAIGKGSFGKVCIVQKN---DTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLE 79
FE+L+ +G+GSFGKV +V+K D ++YAMK + K R+ VR E I+ +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-ERDILVEVN 131
Query: 80 HPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 139
HPF+V L Y+FQ E +++++D L GGD+ L + V F EE VK ++ EL +ALD+L
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 191
Query: 140 QRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPEMFSSRKGA 198
I++RD+KP+NILLDE GH+ +TDF ++ + +E + + GT YMAPE+ + R
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR--- 248
Query: 199 GYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLK 258
G+S + DWWS GV +E+L G P+ E ++ + P S E SLL+
Sbjct: 249 GHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
Query: 259 KLLEPNPDQRFSQ--LSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGR 304
L + NP R + +++ + +I+WD ++++ + P F P G+
Sbjct: 306 MLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
Score = 92.8 bits (229), Expect = 5e-19
Identities = 77/260 (29%), Positives = 123/260 (47%), Gaps = 24/260 (9%)
Query: 23 FEILRAIGKGSFG--KVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL-E 79
+E+ IG GS+ K CI T +A+K ++K K R+ +E++I+ +
Sbjct: 426 YELKEDIGVGSYSVCKRCI--HATTNMEFAVKIIDKSK-------RDPSEEIEILMRYGQ 476
Query: 80 HPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 139
HP ++ L F D +++V DL+ GG+L + + F E + + +DYL
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 536
Query: 140 QRIIHRDMKPDNIL-LDEHG---HVHITDFNIAAMLPRET-QITTMAGTKPYMAPEMFSS 194
Q ++HRD+KP NIL +DE + I DF A L E + T T ++APE+
Sbjct: 537 QGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ 596
Query: 195 RKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSA-W---S 250
+ GY A D WSLGV Y +L G P+ + + +EI+ + W S
Sbjct: 597 Q---GYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNIS 653
Query: 251 QEMVSLLKKLLEPNPDQRFS 270
LL +L +P QR++
Sbjct: 654 DGAKDLLSHMLHMDPHQRYT 673
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 191 bits (484), Expect = 1e-48
Identities = 100/309 (32%), Positives = 173/309 (55%), Gaps = 19/309 (6%)
Query: 5 TSRKPPVFDENEDVNFDH--------FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNK 56
TS+ + +E D + H F+ L+ +GKG+FGKV +V++ + K YAMK + K
Sbjct: 122 TSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKK 181
Query: 57 QKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV 116
+ + ++EV + E ++++ HPFL +L YSFQ ++ + V++ + GG+L +HL +
Sbjct: 182 EVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER 241
Query: 117 HFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRET 175
F E+ + + E+V ALDYL + +I++RD+K +N++LD+ GH+ ITDF + +
Sbjct: 242 VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA 301
Query: 176 QITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIV 235
+ T GT Y+APE+ Y AVDWW LGV YE++ GR P++ + E++
Sbjct: 302 TMKTFCGTPEYLAPEVLEDN---DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 358
Query: 236 HTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQ 291
+ + +P S + SLL LL +P++R ++ + + +NW V+
Sbjct: 359 LMED---IKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 292 KRLIPGFIP 300
K+L+P F P
Sbjct: 416 KKLVPPFKP 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 191 bits (484), Expect = 1e-48
Identities = 100/309 (32%), Positives = 173/309 (55%), Gaps = 19/309 (6%)
Query: 5 TSRKPPVFDENEDVNFDH--------FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNK 56
TS+ + +E D + H F+ L+ +GKG+FGKV +V++ + K YAMK + K
Sbjct: 122 TSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKK 181
Query: 57 QKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV 116
+ + ++EV + E ++++ HPFL +L YSFQ ++ + V++ + GG+L +HL +
Sbjct: 182 EVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER 241
Query: 117 HFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRET 175
F E+ + + E+V ALDYL + +I++RD+K +N++LD+ GH+ ITDF + +
Sbjct: 242 VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA 301
Query: 176 QITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIV 235
+ T GT Y+APE+ Y AVDWW LGV YE++ GR P++ + E++
Sbjct: 302 TMKTFCGTPEYLAPEVLEDN---DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 358
Query: 236 HTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQ 291
+ + +P S + SLL LL +P++R ++ + + +NW V+
Sbjct: 359 LMED---IKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 292 KRLIPGFIP 300
K+L+P F P
Sbjct: 416 KKLVPPFKP 424
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 191 bits (484), Expect = 1e-48
Identities = 106/294 (36%), Positives = 167/294 (56%), Gaps = 15/294 (5%)
Query: 15 NEDVNFDHFEILRAIGKGSFGKVCIVQK---NDTKKMYAMKYMNKQKCVERNEVRNVFKE 71
+E + HFE+L+ +G+GSFGKV +V+K D+ +YAMK + K R+ VR E
Sbjct: 63 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-E 121
Query: 72 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 131
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V F EE VK ++ EL
Sbjct: 122 RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 181
Query: 132 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPE 190
+ LD+L + II+RD+KP+NILLDE GH+ +TDF ++ + E + + GT YMAPE
Sbjct: 182 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 241
Query: 191 MFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWS 250
+ + + G+S + DWWS GV +E+L G P+ KE + + P S
Sbjct: 242 VVNRQ---GHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLS 295
Query: 251 QEMVSLLKKLLEPNPDQRFSQ----LSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
E SLL+ L + NP R +++ + + I+W+ ++++ + P F P
Sbjct: 296 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 349
Score = 100 bits (249), Expect = 2e-21
Identities = 75/266 (28%), Positives = 127/266 (47%), Gaps = 18/266 (6%)
Query: 21 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 80
D + + IG GS+ + T YA+K ++K K E+ E+ + G +H
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-----EILLRYG-QH 478
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 140
P ++ L + D + +++V +L+ GG+L + + F E + + ++YL +Q
Sbjct: 479 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ 538
Query: 141 RIIHRDMKPDNIL-LDEHGH---VHITDFNIAAMLPRET-QITTMAGTKPYMAPEMFSSR 195
++HRD+KP NIL +DE G+ + I DF A L E + T T ++APE+
Sbjct: 539 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL--- 595
Query: 196 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSA-W---SQ 251
K GY D WSLG+ Y +L G P+ S + +EI+ + T W S+
Sbjct: 596 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 655
Query: 252 EMVSLLKKLLEPNPDQRFSQLSDVQN 277
L+ K+L +P QR + +Q+
Sbjct: 656 TAKDLVSKMLHVDPHQRLTAKQVLQH 681
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 191 bits (484), Expect = 1e-48
Identities = 106/294 (36%), Positives = 167/294 (56%), Gaps = 15/294 (5%)
Query: 15 NEDVNFDHFEILRAIGKGSFGKVCIVQK---NDTKKMYAMKYMNKQKCVERNEVRNVFKE 71
+E + HFE+L+ +G+GSFGKV +V+K D+ +YAMK + K R+ VR E
Sbjct: 54 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-E 112
Query: 72 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 131
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V F EE VK ++ EL
Sbjct: 113 RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 172
Query: 132 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPE 190
+ LD+L + II+RD+KP+NILLDE GH+ +TDF ++ + E + + GT YMAPE
Sbjct: 173 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 232
Query: 191 MFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWS 250
+ + + G+S + DWWS GV +E+L G P+ KE + + P S
Sbjct: 233 VVNRQ---GHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLS 286
Query: 251 QEMVSLLKKLLEPNPDQRFSQ----LSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
E SLL+ L + NP R +++ + + I+W+ ++++ + P F P
Sbjct: 287 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 340
Score = 100 bits (249), Expect = 2e-21
Identities = 75/266 (28%), Positives = 127/266 (47%), Gaps = 18/266 (6%)
Query: 21 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 80
D + + IG GS+ + T YA+K ++K K E+ E+ + G +H
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-----EILLRYG-QH 469
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 140
P ++ L + D + +++V +L+ GG+L + + F E + + ++YL +Q
Sbjct: 470 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ 529
Query: 141 RIIHRDMKPDNIL-LDEHGH---VHITDFNIAAMLPRET-QITTMAGTKPYMAPEMFSSR 195
++HRD+KP NIL +DE G+ + I DF A L E + T T ++APE+
Sbjct: 530 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL--- 586
Query: 196 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSA-W---SQ 251
K GY D WSLG+ Y +L G P+ S + +EI+ + T W S+
Sbjct: 587 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 646
Query: 252 EMVSLLKKLLEPNPDQRFSQLSDVQN 277
L+ K+L +P QR + +Q+
Sbjct: 647 TAKDLVSKMLHVDPHQRLTAKQVLQH 672
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 191 bits (484), Expect = 1e-48
Identities = 96/288 (33%), Positives = 171/288 (59%), Gaps = 12/288 (4%)
Query: 17 DVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQ 76
+ + FE + +G GSFG+V +V+ T++ YAMK ++KQK V+ ++ + E +I+Q
Sbjct: 38 NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQ 97
Query: 77 GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDY 136
+ PFLV L Y+F+D +++MV++ + GG++ HL++ F E + + ++V+ +Y
Sbjct: 98 AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157
Query: 137 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRK 196
L + +I+RD+KP+N+L+D G++ +TDF A + T T+ GT Y+APE+ S+
Sbjct: 158 LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSK- 214
Query: 197 GAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSL 256
GY+ AVDWW+LGV YE+ G P+ + +I + V +PS +S ++ L
Sbjct: 215 --GYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFPSHFSSDLKDL 269
Query: 257 LKKLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIP 300
L+ LL+ + +RF L SD++ + +W A++Q+++ FIP
Sbjct: 270 LRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 317
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 191 bits (484), Expect = 1e-48
Identities = 96/288 (33%), Positives = 171/288 (59%), Gaps = 12/288 (4%)
Query: 17 DVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQ 76
+ + FE + +G GSFG+V +V+ T++ YAMK ++KQK V+ ++ + E +I+Q
Sbjct: 85 NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQ 144
Query: 77 GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDY 136
+ PFLV L Y+F+D +++MV++ + GG++ HL++ F E + + ++V+ +Y
Sbjct: 145 AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 204
Query: 137 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRK 196
L + +I+RD+KP+N+L+D G++ +TDF A + T T+ GT Y+APE+ S+
Sbjct: 205 LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSK- 261
Query: 197 GAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSL 256
GY+ AVDWW+LGV YE+ G P+ + +I + V +PS +S ++ L
Sbjct: 262 --GYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFPSHFSSDLKDL 316
Query: 257 LKKLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIP 300
L+ LL+ + +RF L SD++ + +W A++Q+++ FIP
Sbjct: 317 LRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 364
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 185 bits (470), Expect = 5e-47
Identities = 100/289 (34%), Positives = 161/289 (55%), Gaps = 12/289 (4%)
Query: 18 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 77
V + FE L+ +GKG+FGKV +V++ T + YAMK + K+ V ++EV + E +++Q
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 78 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 137
HPFL L YSFQ + + V++ GG+L +HL + F E+ + + E+V ALDYL
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 138 QNQR-IIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRETQITTMAGTKPYMAPEMFSSR 195
+++ +++RD+K +N++LD+ GH+ ITDF + + + T GT Y+APE+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 196 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 255
Y AVDWW LGV YE++ GR P++ + E++ E + +P E S
Sbjct: 325 ---DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKS 378
Query: 256 LLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
LL LL+ +P QR ++ + I W V++K+L P F P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 185 bits (470), Expect = 5e-47
Identities = 100/289 (34%), Positives = 161/289 (55%), Gaps = 12/289 (4%)
Query: 18 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 77
V + FE L+ +GKG+FGKV +V++ T + YAMK + K+ V ++EV + E +++Q
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 78 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 137
HPFL L YSFQ + + V++ GG+L +HL + F E+ + + E+V ALDYL
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 138 QNQR-IIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRETQITTMAGTKPYMAPEMFSSR 195
+++ +++RD+K +N++LD+ GH+ ITDF + + + T GT Y+APE+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 196 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 255
Y AVDWW LGV YE++ GR P++ + E++ E + +P E S
Sbjct: 325 ---DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKS 378
Query: 256 LLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
LL LL+ +P QR ++ + I W V++K+L P F P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 185 bits (470), Expect = 5e-47
Identities = 100/289 (34%), Positives = 161/289 (55%), Gaps = 12/289 (4%)
Query: 18 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 77
V + FE L+ +GKG+FGKV +V++ T + YAMK + K+ V ++EV + E +++Q
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 78 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 137
HPFL L YSFQ + + V++ GG+L +HL + F E+ + + E+V ALDYL
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 138 QNQR-IIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRETQITTMAGTKPYMAPEMFSSR 195
+++ +++RD+K +N++LD+ GH+ ITDF + + + T GT Y+APE+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 196 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 255
Y AVDWW LGV YE++ GR P++ + E++ E + +P E S
Sbjct: 325 ---DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKS 378
Query: 256 LLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
LL LL+ +P QR ++ + I W V++K+L P F P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 185 bits (470), Expect = 5e-47
Identities = 101/288 (35%), Positives = 161/288 (55%), Gaps = 19/288 (6%)
Query: 23 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIM-QGLEHP 81
F+ L+ IGKG++GKV + ++ YA+K + K+ +++ E ++ E ++ + + HP
Sbjct: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQR 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + + E+ A+ YL +
Sbjct: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154
Query: 142 IIHRDMKPDNILLDEHGHVHITDFNIA--AMLPRETQITTMAGTKPYMAPEMFSSRKGAG 199
II+RD+KP+NILLD GHV +TDF + + P +T +T GT Y+APE+
Sbjct: 155 IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT-TSTFCGTPEYLAPEVLRKEP--- 210
Query: 200 YSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTV---VTYPSAWSQEMVSL 256
Y AVDWW LG YE+L G P++ S+++ +E + + P + L
Sbjct: 211 YDRAVDWWCLGAVLYEMLHGLPPFY------SQDVSQMYENILHQPLQIPGGRTVAACDL 264
Query: 257 LKKLLEPNPDQRFSQLSD---VQNFPYMNDINWDAVFQKRLIPGFIPN 301
L+ LL + QR +D ++N + + INWD ++ KRL P F PN
Sbjct: 265 LQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPN 312
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 185 bits (470), Expect = 5e-47
Identities = 101/288 (35%), Positives = 161/288 (55%), Gaps = 19/288 (6%)
Query: 23 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIM-QGLEHP 81
F+ L+ IGKG++GKV + ++ YA+K + K+ +++ E ++ E ++ + + HP
Sbjct: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQR 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + + E+ A+ YL +
Sbjct: 155 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 214
Query: 142 IIHRDMKPDNILLDEHGHVHITDFNIA--AMLPRETQITTMAGTKPYMAPEMFSSRKGAG 199
II+RD+KP+NILLD GHV +TDF + + P +T +T GT Y+APE+
Sbjct: 215 IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT-TSTFCGTPEYLAPEVLRKEP--- 270
Query: 200 YSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTV---VTYPSAWSQEMVSL 256
Y AVDWW LG YE+L G P++ S+++ +E + + P + L
Sbjct: 271 YDRAVDWWCLGAVLYEMLHGLPPFY------SQDVSQMYENILHQPLQIPGGRTVAACDL 324
Query: 257 LKKLLEPNPDQRFSQLSD---VQNFPYMNDINWDAVFQKRLIPGFIPN 301
L+ LL + QR +D ++N + + INWD ++ KRL P F PN
Sbjct: 325 LQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPN 372
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 185 bits (469), Expect = 7e-47
Identities = 103/286 (36%), Positives = 159/286 (55%), Gaps = 15/286 (5%)
Query: 23 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIM-QGLEHP 81
F+ L+ IGKGSFGKV + ++ K YA+K + K+ + R E +++ E ++ + ++HP
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQR 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + + E+ AL YL + +
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 142 IIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRETQITTMAGTKPYMAPEMFSSRKGAGY 200
I++RD+KP+NILLD GHV +TDF + + TT GT Y+APE+ + Y
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP---Y 338
Query: 201 SFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKE-IVH-TFETTVVTYPSAWSQEMVSLLK 258
VDWW LG YE+L G P++ R + I+H +AW S+L+
Sbjct: 339 DNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW-----SILE 393
Query: 259 KLLEPNPDQRFSQLSD---VQNFPYMNDINWDAVFQKRLIPGFIPN 301
+LLE + R D +QN P+ ++W + QK++ P F PN
Sbjct: 394 ELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPN 439
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 185 bits (469), Expect = 7e-47
Identities = 103/286 (36%), Positives = 159/286 (55%), Gaps = 15/286 (5%)
Query: 23 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIM-QGLEHP 81
F+ L+ IGKGSFGKV + ++ K YA+K + K+ + R E +++ E ++ + ++HP
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQR 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + + E+ AL YL + +
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 142 IIHRDMKPDNILLDEHGHVHITDFNIAAM-LPRETQITTMAGTKPYMAPEMFSSRKGAGY 200
I++RD+KP+NILLD GHV +TDF + + TT GT Y+APE+ + Y
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP---Y 338
Query: 201 SFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKE-IVH-TFETTVVTYPSAWSQEMVSLLK 258
VDWW LG YE+L G P++ R + I+H +AW S+L+
Sbjct: 339 DNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW-----SILE 393
Query: 259 KLLEPNPDQRFSQLSD---VQNFPYMNDINWDAVFQKRLIPGFIPN 301
+LLE + R D +QN P+ ++W + QK++ P F PN
Sbjct: 394 ELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPN 439
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 184 bits (466), Expect = 2e-46
Identities = 99/306 (32%), Positives = 169/306 (55%), Gaps = 10/306 (3%)
Query: 15 NEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE--- 71
N + + F + R IG+G FG+V +K DT KMYAMK ++K++ + E
Sbjct: 183 NIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
Query: 72 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 131
L ++ + PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E+ ++ + E++
Sbjct: 243 LSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEII 302
Query: 132 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 191
+ L+++ N+ +++RD+KP NILLDEHGH I+D +A ++ ++ GT YMAPE+
Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV-GTHGYMAPEV 361
Query: 192 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 251
+KG Y + DW+SLG ++LLRG P+ + EI T V P +S
Sbjct: 362 L--QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSP 419
Query: 252 EMVSLLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNC 307
E+ SLL+ LL+ + +R +V+ + ++W V+ ++ P IP +G +N
Sbjct: 420 ELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNA 479
Query: 308 DPTFEL 313
F++
Sbjct: 480 ADAFDI 485
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 183 bits (465), Expect = 2e-46
Identities = 99/308 (32%), Positives = 166/308 (53%), Gaps = 12/308 (3%)
Query: 18 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQ- 76
+ + F + + +GKGSFGKV + + T + +A+K + K + ++V E +++
Sbjct: 375 LKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 434
Query: 77 GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDY 136
EHPFL +++ +FQ +E++F V++ L GGDL YH+Q F + E+++ L +
Sbjct: 435 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 494
Query: 137 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPEMFSSR 195
L ++ I++RD+K DNILLD+ GH+ I DF + + + + T GT Y+APE+ +
Sbjct: 495 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ 554
Query: 196 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 255
K Y+ +VDWWS GV YE+L G+ P+H +E+ H+ YP +E
Sbjct: 555 K---YNHSVDWWSFGVLLYEMLIGQSPFH---GQDEEELFHSIRMDNPFYPRWLEKEAKD 608
Query: 256 LLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPN-KGRLNCDPTFELE 314
LL KL P++R D++ P +INW+ + +K + P F P K +C +
Sbjct: 609 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS---NFD 665
Query: 315 EMILESKP 322
+ L KP
Sbjct: 666 KEFLNEKP 673
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 183 bits (465), Expect = 2e-46
Identities = 96/309 (31%), Positives = 167/309 (54%), Gaps = 10/309 (3%)
Query: 14 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQ 73
E + V + F R +GKG FG+VC Q T KMYA K + K++ +R E +
Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 237
Query: 74 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICELV 131
I++ ++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E+ + EL
Sbjct: 238 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 297
Query: 132 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 191
L+ LQ +RI++RD+KP+NILLD+ GH+ I+D +A +P ++ GT YMAPE+
Sbjct: 298 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 357
Query: 192 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPY-HIRSSTSSKEIVHTFETTVVTYPSAWS 250
++ K Y+F+ DWW LG YE+++G P+ + +E+ + Y +S
Sbjct: 358 VNNEK---YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFS 414
Query: 251 QEMVSLLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLN 306
++ S+ + LL NP +R + V+ P DIN+ + L P F P+ +
Sbjct: 415 EDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVY 474
Query: 307 CDPTFELEE 315
C ++E+
Sbjct: 475 CKDVLDIEQ 483
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,344,647
Number of Sequences: 37866
Number of extensions: 680989
Number of successful extensions: 4333
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 670
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 2173
Number of HSP's gapped (non-prelim): 929
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.