Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 162951881

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
         (718 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]          1445   0.0  
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]           1428   0.0  
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]          1030   0.0  
gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]           1030   0.0  
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]           970   0.0  
gi|150456432 unc-51-like kinase 3 [Homo sapiens]                      115   1e-25
gi|93004081 polo-like kinase 2 [Homo sapiens]                         115   1e-25
gi|4507831 Unc-51-like kinase 1 [Homo sapiens]                        115   2e-25
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               112   2e-24
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   110   6e-24
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]              109   1e-23
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]               109   1e-23
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           108   2e-23
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   108   2e-23
gi|23308722 TTK protein kinase [Homo sapiens]                         108   2e-23
gi|62865643 aurora kinase C isoform 3 [Homo sapiens]                  107   3e-23
gi|62865641 aurora kinase C isoform 2 [Homo sapiens]                  107   3e-23
gi|62865639 aurora kinase C isoform 1 [Homo sapiens]                  107   3e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                107   3e-23
gi|121114283 polo-like kinase 4 [Homo sapiens]                        107   4e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   106   7e-23
gi|109255245 serine/threonine kinase 17a [Homo sapiens]               106   9e-23
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   105   1e-22
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   105   1e-22
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   105   1e-22
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma...   105   1e-22
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma...   105   1e-22
gi|83776600 aurora kinase B [Homo sapiens]                            105   2e-22
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   104   2e-22
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   104   2e-22

>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
          Length = 718

 Score = 1445 bits (3740), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 1   MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
           MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
Sbjct: 1   MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60

Query: 61  RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV 120
           RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV
Sbjct: 61  RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV 120

Query: 121 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL 180
           MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
Sbjct: 121 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL 180

Query: 181 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK 240
           TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK
Sbjct: 181 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK 240

Query: 241 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR 300
           LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR
Sbjct: 241 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR 300

Query: 301 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG 360
           EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
Sbjct: 301 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG 360

Query: 361 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS 420
           HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS
Sbjct: 361 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS 420

Query: 421 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480
           EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS
Sbjct: 421 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480

Query: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540
           LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
Sbjct: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540

Query: 541 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE 600
           PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE
Sbjct: 541 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE 600

Query: 601 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 660
           PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA
Sbjct: 601 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 660

Query: 661 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 718
           KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
Sbjct: 661 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 718


>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
          Length = 750

 Score = 1428 bits (3697), Expect = 0.0
 Identities = 718/750 (95%), Positives = 718/750 (95%), Gaps = 32/750 (4%)

Query: 1   MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
           MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
Sbjct: 1   MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60

Query: 61  RNRKRKAEPYETSQGKGTPRGHKISDYFE------------------------------- 89
           RNRKRKAEPYETSQGKGTPRGHKISDYFE                               
Sbjct: 61  RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 120

Query: 90  -RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 148
            RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
Sbjct: 121 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 180

Query: 149 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 208
           NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
Sbjct: 181 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 240

Query: 209 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 268
           ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT
Sbjct: 241 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 300

Query: 269 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 328
           TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
Sbjct: 301 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 360

Query: 329 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 388
           KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK
Sbjct: 361 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 420

Query: 389 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 448
           RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE
Sbjct: 421 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 480

Query: 449 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 508
           KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
Sbjct: 481 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 540

Query: 509 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 568
           SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD
Sbjct: 541 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 600

Query: 569 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 628
           DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG
Sbjct: 601 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 660

Query: 629 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688
           HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL
Sbjct: 661 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720

Query: 689 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 718
           PHIRKSVSTSSPAGAAIASTSGASNNSSSN
Sbjct: 721 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 750


>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
          Length = 718

 Score = 1030 bits (2662), Expect = 0.0
 Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%)

Query: 2   MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
           M+ELHSLDPRRQELLEARFTGV              +K   N+ESSN S  S+GSLSDKE
Sbjct: 1   MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60

Query: 50  VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103
            ETPEKKQ++  R RKRKAE   E+SQGK    RGHKISDYFE +      P+ G+  + 
Sbjct: 61  SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120

Query: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163
                    + P+                            S + NSPS T     +H  
Sbjct: 121 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 153

Query: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223
              KQ+S +  QT  DLT+ K++ALE++K  DLEKKEGRIDDLLRANCDLRRQIDEQQK+
Sbjct: 154 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 211

Query: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283
           LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG
Sbjct: 212 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 271

Query: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340
           +AFQNL+KQQE +N QRE+IERQRK+LAKRKPP     QAP   +E KQRK+K  NGAEN
Sbjct: 272 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 331

Query: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391
           +          LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+
Sbjct: 332 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 391

Query: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451
           NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE
Sbjct: 392 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 451

Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511
           NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK
Sbjct: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 511

Query: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571
           EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 512 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 571

Query: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631
             VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ
Sbjct: 572 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 630

Query: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
           SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+
Sbjct: 631 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 690

Query: 692 RKSVSTSS--PAGAAIASTSGASN 713
           R+S S+ +   AG   + T  +S+
Sbjct: 691 RRSNSSGNLHMAGLTASPTPPSSS 714


>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
          Length = 766

 Score = 1030 bits (2662), Expect = 0.0
 Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%)

Query: 2   MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
           M+ELHSLDPRRQELLEARFTGV              +K   N+ESSN S  S+GSLSDKE
Sbjct: 49  MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108

Query: 50  VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103
            ETPEKKQ++  R RKRKAE   E+SQGK    RGHKISDYFE +      P+ G+  + 
Sbjct: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168

Query: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163
                    + P+                            S + NSPS T     +H  
Sbjct: 169 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 201

Query: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223
              KQ+S +  QT  DLT+ K++ALE++K  DLEKKEGRIDDLLRANCDLRRQIDEQQK+
Sbjct: 202 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 259

Query: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283
           LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG
Sbjct: 260 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 319

Query: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340
           +AFQNL+KQQE +N QRE+IERQRK+LAKRKPP     QAP   +E KQRK+K  NGAEN
Sbjct: 320 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 379

Query: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391
           +          LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+
Sbjct: 380 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 439

Query: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451
           NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE
Sbjct: 440 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 499

Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511
           NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK
Sbjct: 500 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 559

Query: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571
           EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 560 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 619

Query: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631
             VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ
Sbjct: 620 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 678

Query: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
           SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+
Sbjct: 679 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738

Query: 692 RKSVSTSS--PAGAAIASTSGASN 713
           R+S S+ +   AG   + T  +S+
Sbjct: 739 RRSNSSGNLHMAGLTASPTPPSSS 762


>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
          Length = 670

 Score =  970 bits (2507), Expect = 0.0
 Identities = 507/683 (74%), Positives = 558/683 (81%), Gaps = 50/683 (7%)

Query: 51  ETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSAA 104
           +TPEKKQ++  R RKRKAE   E+SQGK    RGHKISDYFE +      P+ G+  +  
Sbjct: 14  KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73

Query: 105 KEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCS 164
                   + P+                            S + NSPS T     +H   
Sbjct: 74  SPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPIV 106

Query: 165 SQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKML 224
             KQ+S +  QT  DLT+ K++ALE++K  DLEKKEGRIDDLLRANCDLRRQIDEQQK+L
Sbjct: 107 QPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLL 164

Query: 225 EKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGY 284
           EKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG+
Sbjct: 165 EKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGF 224

Query: 285 AFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAENE 341
           AFQNL+KQQE +N QRE+IERQRK+LAKRKPP     QAP   +E KQRK+K  NGAEN+
Sbjct: 225 AFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEND 284

Query: 342 T---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHN 392
                     LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+N
Sbjct: 285 PFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINN 344

Query: 393 EDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKEN 452
           EDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKEN
Sbjct: 345 EDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKEN 404

Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512
           YHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEKE
Sbjct: 405 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 464

Query: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572
           ARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY 
Sbjct: 465 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 524

Query: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632
            VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQS
Sbjct: 525 -VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQS 583

Query: 633 QQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIR 692
           QQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+R
Sbjct: 584 QQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMR 643

Query: 693 KSVSTSS--PAGAAIASTSGASN 713
           +S S+ +   AG   + T  +S+
Sbjct: 644 RSNSSGNLHMAGLTASPTPPSSS 666


>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
          Length = 472

 Score =  115 bits (289), Expect = 1e-25
 Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 25/287 (8%)

Query: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461
           P   D ++L   LG G ++ VYKA+   + R V        K+      EN       E 
Sbjct: 8   PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63

Query: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521
            I K + HP IV+L D F  D+D+   ++E+C G DL  ++   +++ EK AR  + Q+ 
Sbjct: 64  EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122

Query: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD-DSYNSVDGMELT 580
           +AL++L+E    I H DLKP NILL +      +K+ DFG ++ M   D  + + G  L 
Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178

Query: 581 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640
                   Y+ PE         +   +VD+WS+GVI Y+ L+G+ PF      +    E 
Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223

Query: 641 TILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
            I     ++ P +P+++ + +  ++R L      RI  Q     P++
Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 270


>gi|93004081 polo-like kinase 2 [Homo sapiens]
          Length = 685

 Score =  115 bits (289), Expect = 1e-25
 Identities = 89/292 (30%), Positives = 136/292 (46%), Gaps = 37/292 (12%)

Query: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461
           PT   RY    +LG+GGF++ Y+  DLT  +  A KI   ++  +  ++E   K    E 
Sbjct: 76  PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131

Query: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521
            +H+ L H  +V+ Y YF  D ++   +LEYC    +   LK  K+++E E R  + QIV
Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190

Query: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTS 581
           + LKYL+E    I+H DLK GN  +       E+K+ DFGL+  ++   +          
Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFI---NEAMELKVGDFGLAARLEPLEHR-------RR 238

Query: 582 QGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT 641
              GT  YL PE  V+ K+     +  D+W++G + Y  L GR PF           E T
Sbjct: 239 TICGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETT 283

Query: 642 ILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688
            LK T     E ++     +   AK  I   L+   EDR  +  +    + L
Sbjct: 284 NLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335


>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
          Length = 1050

 Score =  115 bits (287), Expect = 2e-25
 Identities = 97/317 (30%), Positives = 148/317 (46%), Gaps = 37/317 (11%)

Query: 413 LLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRI 472
           L+G G F+ V+K     E+  + V +  +NK    + +    K    E +I KEL H  I
Sbjct: 21  LIGHGAFAVVFKGRH-REKHDLEVAVKCINKKNLAKSQTLLGK----EIKILKELKHENI 75

Query: 473 VKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKP 532
           V LYD+  +  +S   V+EYC G DL  YL   + +SE   R  + QI  A++ L+    
Sbjct: 76  VALYDFQEM-ANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS--K 132

Query: 533 PIIHYDLKPGNILLVNGTACG------EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGT 586
            IIH DLKP NILL N            +KI DFG ++ +  +         + +   G+
Sbjct: 133 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM--------MAATLCGS 184

Query: 587 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI---LQENTIL 643
             Y+ PE  +          K D+WS+G I YQCL G+ PF    S QD+    ++N  L
Sbjct: 185 PMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNKTL 239

Query: 644 KATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL--LPHIRKSVSTSSPA 701
             T     P+    P  +  +   L    +DR+D  +    P+L   P +RKS     P+
Sbjct: 240 VPT----IPRETSAP-LRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPS 294

Query: 702 GAAIASTSGASNNSSSN 718
             +  S S +S++S+S+
Sbjct: 295 YPSSGSGSSSSSSSTSH 311


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  112 bits (279), Expect = 2e-24
 Identities = 90/296 (30%), Positives = 140/296 (47%), Gaps = 36/296 (12%)

Query: 387 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 446
           +KR H++ N        L  RY L   LG+G + +V +A +    R VA+K  + +K   
Sbjct: 42  VKRHHHKHN--------LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI-- 91

Query: 447 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 506
             K E    H  RE  I   L+HP I+ +Y+ F  + D    ++EY    +L  Y+ + +
Sbjct: 92  --KDEQDMVHIRREIEIMSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERR 148

Query: 507 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 566
            +SE+E R    QIV+A+ Y +  K  ++H DLK  NILL +      IKI DFGLS + 
Sbjct: 149 RLSERETRHFFRQIVSAVHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLY 203

Query: 567 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 626
             D +             G+  Y  PE  V G+  P    +VD W++GV+ Y  +YG  P
Sbjct: 204 QKDKF--------LQTFCGSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMP 252

Query: 627 FGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 682
           F     +  I Q    + + E + P +P    +A+  IR  L    + R  ++ +A
Sbjct: 253 FDGFDHKNLIRQ----ISSGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIA 301


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  110 bits (274), Expect = 6e-24
 Identities = 96/311 (30%), Positives = 154/311 (49%), Gaps = 33/311 (10%)

Query: 394 DNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK-IHQLNKNWRDEKKEN 452
           +  ++K    + D Y    +LG G FSEV  A D   Q+ VA+K I +     ++   EN
Sbjct: 6   EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65

Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512
                  E  +  ++ HP IV L D +      +  +++   G +L   + +    +E++
Sbjct: 66  -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117

Query: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572
           A  +I Q+++A+KYL+++   I+H DLKP N+L  +     +I I+DFGLSK+ D  S  
Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173

Query: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632
                 + S   GT  Y+ PE  V+ ++P   S  VD WS+GVI Y  L G  PF ++++
Sbjct: 174 ------VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEN 222

Query: 633 QQDILQENTILKAT-EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQ------LACDP 685
              + ++  ILKA  E   P    ++  AK FIR  +    E R   +Q      +A D 
Sbjct: 223 DAKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDT 280

Query: 686 YLLPHIRKSVS 696
            L  +I +SVS
Sbjct: 281 ALDKNIHQSVS 291


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score =  109 bits (272), Expect = 1e-23
 Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%)

Query: 404 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 462
           L D Y++   LG G   EV  AF+    + VA+KI    K      +E +   +   E  
Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318

Query: 463 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 522
           I K+L+HP I+K+ ++F  D + +  VLE  EG +L   +  +K + E   +    Q++ 
Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376

Query: 523 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 582
           A++YL+E    IIH DLKP N+LL +      IKITDFG SKI+ + S        L   
Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 426

Query: 583 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 642
             GT  YL PE  +V       +  VD WS+GVI + CL G  PF  +++Q  +  + T 
Sbjct: 427 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 484

Query: 643 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
             + +  F P+    V+ +A   +++ L    + R   ++    P+L
Sbjct: 485 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score =  109 bits (272), Expect = 1e-23
 Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%)

Query: 404 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 462
           L D Y++   LG G   EV  AF+    + VA+KI    K      +E +   +   E  
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275

Query: 463 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 522
           I K+L+HP I+K+ ++F  D + +  VLE  EG +L   +  +K + E   +    Q++ 
Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333

Query: 523 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 582
           A++YL+E    IIH DLKP N+LL +      IKITDFG SKI+ + S        L   
Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 383

Query: 583 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 642
             GT  YL PE  +V       +  VD WS+GVI + CL G  PF  +++Q  +  + T 
Sbjct: 384 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 441

Query: 643 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
             + +  F P+    V+ +A   +++ L    + R   ++    P+L
Sbjct: 442 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  108 bits (270), Expect = 2e-23
 Identities = 96/297 (32%), Positives = 143/297 (48%), Gaps = 39/297 (13%)

Query: 387 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 446
           +KR H++ N        L  RY  L  LG+G + +V KA + +  R VA+K  + +K   
Sbjct: 40  VKRHHHKHN--------LRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKI-- 88

Query: 447 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 506
             K E    H  RE  I   L+HP I+ +++ F  ++     V+EY    DL  Y+ + +
Sbjct: 89  --KDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE-NSSKIVIVMEYASRGDLYDYISERQ 145

Query: 507 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 566
            +SE+EAR    QIV+A+ Y ++ +  ++H DLK  NILL    A G IKI DFGLS + 
Sbjct: 146 QLSEREARHFFRQIVSAVHYCHQNR--VVHRDLKLENILL---DANGNIKIADFGLSNLY 200

Query: 567 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 626
               +             G+  Y  PE  V GK  P    +VD WS+GV+ Y  ++G  P
Sbjct: 201 HQGKF--------LQTFCGSPLYASPE-IVNGK--PYTGPEVDSWSLGVLLYILVHGTMP 249

Query: 627 F-GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 682
           F GH+     IL +   +     + PPKP    +A   IR  L      R  ++ +A
Sbjct: 250 FDGHDHK---ILVKQ--ISNGAYREPPKP---SDACGLIRWLLMVNPTRRATLEDVA 298


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  108 bits (270), Expect = 2e-23
 Identities = 88/300 (29%), Positives = 142/300 (47%), Gaps = 26/300 (8%)

Query: 389 RIHNEDNSQFKDHPT-LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRD 447
           R   +D S +K   T +   ++ + +LG G FSEV+        +  A+K  + +  +RD
Sbjct: 3   RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62

Query: 448 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL 507
              EN       E  + K++ H  IV L D +   T  +  V++   G +L   + +  +
Sbjct: 63  SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114

Query: 508 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 567
            +EK+A  +I Q+++A+KYL+E    I+H DLKP N+L +      +I ITDFGLSK+  
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172

Query: 568 DDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 627
           +          + S   GT  Y+ PE  V+ ++P   S  VD WS+GVI Y  L G  PF
Sbjct: 173 NG---------IMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF 219

Query: 628 GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
              +  +  L E       E + P    ++  AK FI   L     +R   ++    P++
Sbjct: 220 --YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277


>gi|23308722 TTK protein kinase [Homo sapiens]
          Length = 857

 Score =  108 bits (269), Expect = 2e-23
 Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 37/292 (12%)

Query: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467
           Y +L  +G GG S+V++  +  +Q Y A+K   L +   ++  ++Y        ++ +  
Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582

Query: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527
           D  +I++LYDY    TD +  ++  C   DL+ +LK+ K +   E +S    ++ A+  +
Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638

Query: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587
           ++    I+H DLKP N L+V+G     +K+ DFG++  M  D+ + V   ++     GT 
Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSVVKDSQV-----GTV 687

Query: 588 WYLPPECFVV-------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640
            Y+PPE           GK   KIS K DVWS+G I Y   YG+ PF      Q I+ + 
Sbjct: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQI 741

Query: 641 TILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           + L A      E++FP  P    + +  ++ CL    + RI + +L   PY+
Sbjct: 742 SKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791


>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
          Length = 275

 Score =  107 bits (268), Expect = 3e-23
 Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)

Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
           LG+G F  VY A        VA+K+  L K+    +KE       RE  I   L HP I+
Sbjct: 15  LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70

Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533
           +LY+YF  D      +LEY    +L   L++ + + E+   +II ++ +AL Y ++ K  
Sbjct: 71  RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127

Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593
           +IH D+KP N+LL      GE+KI DFG S         ++          GT  YLPPE
Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 175

Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650
                 E      KVD+W +GV+ Y+ L G  PF    H+++ + IL+        +V+F
Sbjct: 176 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 224

Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693
           P    +   A+  I R L Y+  +R+ + Q+   P++  H R+
Sbjct: 225 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265


>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
          Length = 290

 Score =  107 bits (268), Expect = 3e-23
 Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)

Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
           LG+G F  VY A        VA+K+  L K+    +KE       RE  I   L HP I+
Sbjct: 30  LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85

Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533
           +LY+YF  D      +LEY    +L   L++ + + E+   +II ++ +AL Y ++ K  
Sbjct: 86  RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142

Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593
           +IH D+KP N+LL      GE+KI DFG S         ++          GT  YLPPE
Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 190

Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650
                 E      KVD+W +GV+ Y+ L G  PF    H+++ + IL+        +V+F
Sbjct: 191 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 239

Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693
           P    +   A+  I R L Y+  +R+ + Q+   P++  H R+
Sbjct: 240 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280


>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
          Length = 309

 Score =  107 bits (268), Expect = 3e-23
 Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)

Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
           LG+G F  VY A        VA+K+  L K+    +KE       RE  I   L HP I+
Sbjct: 49  LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104

Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533
           +LY+YF  D      +LEY    +L   L++ + + E+   +II ++ +AL Y ++ K  
Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161

Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593
           +IH D+KP N+LL      GE+KI DFG S         ++          GT  YLPPE
Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 209

Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650
                 E      KVD+W +GV+ Y+ L G  PF    H+++ + IL+        +V+F
Sbjct: 210 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 258

Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693
           P    +   A+  I R L Y+  +R+ + Q+   P++  H R+
Sbjct: 259 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score =  107 bits (268), Expect = 3e-23
 Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 29/295 (9%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHK 465
           ++Y +L ++G G F  VYK       + VA+K   + K  R EK+    ++  RE  I +
Sbjct: 2   EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKEL---RNLQREIEIMR 56

Query: 466 ELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALK 525
            L HP IV + D F  D +    V +Y EG +L   L+    + E + ++I  Q+V+AL 
Sbjct: 57  GLRHPNIVHMLDSFETDKE-VVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114

Query: 526 YLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 585
           YL+  +  I+H D+KP NILL  G   G IK+ DFG ++ M      S + M LTS   G
Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAM------STNTMVLTSI-KG 162

Query: 586 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKA 645
           T  Y+ PE  +V + P    +  D+WSVG I Y+   G  PF        I Q  +++  
Sbjct: 163 TPLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILK 214

Query: 646 TEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSP 700
             V++P    ++P  K F++  L      R+    L   P++  H+      + P
Sbjct: 215 DPVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGP 267


>gi|121114283 polo-like kinase 4 [Homo sapiens]
          Length = 970

 Score =  107 bits (267), Expect = 4e-23
 Identities = 93/316 (29%), Positives = 148/316 (46%), Gaps = 40/316 (12%)

Query: 412 HLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPR 471
           +LLG+G F+ VY+A  +     VA+K+      +    K    +    E +IH +L HP 
Sbjct: 16  NLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHCQLKHPS 71

Query: 472 IVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIIMQIVNALKYLNEI 530
           I++LY+YF  D++    VLE C   +++ YLK   K  SE EAR  + QI+  + YL+  
Sbjct: 72  ILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS- 129

Query: 531 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLS---KIMDDDSYNSVDGMELTSQGAGTY 587
              I+H DL   N+LL        IKI DFGL+   K+  +  Y             GT 
Sbjct: 130 -HGILHRDLTLSNLLLTRNM---NIKIADFGLATQLKMPHEKHYTL----------CGTP 175

Query: 588 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE 647
            Y+ PE  +  +    + +  DVWS+G +FY  L GR PF  +        +NT+ K   
Sbjct: 176 NYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTLNKVVL 225

Query: 648 VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK------SVSTSSPA 701
             +     ++ EAK  I + L     DR+ +  +   P++  +         +V  S  +
Sbjct: 226 ADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDS 285

Query: 702 GAAIASTSGASNNSSS 717
           G A  ST+  +++S+S
Sbjct: 286 GHATISTAITASSSTS 301


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  106 bits (265), Expect = 7e-23
 Identities = 89/281 (31%), Positives = 133/281 (47%), Gaps = 30/281 (10%)

Query: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467
           Y LL  +G+G F++V  A  +   R VA+KI       + +   +  +   RE RI K L
Sbjct: 59  YRLLRTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPSSLQKLFREVRIMKGL 113

Query: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527
           +HP IVKL++    +   +  V+EY    ++  YL  H  M EKEAR+   QIV+A+ Y 
Sbjct: 114 NHPNIVKLFEVIETEKTLYL-VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 172

Query: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587
           ++    I+H DLK  N+LL    A   IKI DFG S        N            G+ 
Sbjct: 173 HQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS--------NEFTLGSKLDTFCGSP 219

Query: 588 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTILKAT 646
            Y  PE F   K       +VD+WS+GVI Y  + G  PF GHN  +   L+E  +    
Sbjct: 220 PYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRGKY 273

Query: 647 EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
            V F     ++ + ++ +RR L      R  ++Q+  D ++
Sbjct: 274 RVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310


>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
          Length = 414

 Score =  106 bits (264), Expect = 9e-23
 Identities = 84/277 (30%), Positives = 138/277 (49%), Gaps = 25/277 (9%)

Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
           LGRG F+ V K       +  A K  +  +  +D + E  H+ A  E       D+P ++
Sbjct: 67  LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELA----QDNPWVI 122

Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDL--DFYLKQHKLMSEKEARSIIMQIVNALKYLNEIK 531
            L++ +   ++    VLEY  G ++       + +   EK+ + ++ QI+  + +L+   
Sbjct: 123 NLHEVYETASEMIL-VLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHT-- 179

Query: 532 PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLP 591
             ++H DLKP NILL + +  G+IKI DFGLS+I+     NS +  E+     GT  Y+ 
Sbjct: 180 RDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILK----NSEELREI----MGTPEYVA 231

Query: 592 PECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI-LKATEVQF 650
           PE  ++  +P  IS   D+WS+GV+ Y  L G  PF  N  Q+  L  + + L  +E +F
Sbjct: 232 PE--ILSYDP--ISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEF 287

Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
               V++  A  FIR  L  + EDR   ++    P+L
Sbjct: 288 ---DVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  105 bits (263), Expect = 1e-22
 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +    T  +  A KI    K + RD +K        RE RI 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
            ++++    I+H DLKP N+LL +      +K+ DFGL+          V G +    G 
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174

Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
           AGT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226

Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           KA    FP      VTPEAK  I + L      RI   Q    P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  105 bits (263), Expect = 1e-22
 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +    T  +  A KI    K + RD +K        RE RI 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
            ++++    I+H DLKP N+LL +      +K+ DFGL+          V G +    G 
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174

Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
           AGT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226

Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           KA    FP      VTPEAK  I + L      RI   Q    P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  105 bits (263), Expect = 1e-22
 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +    T  +  A KI    K + RD +K        RE RI 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
            ++++    I+H DLKP N+LL +      +K+ DFGL+          V G +    G 
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174

Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
           AGT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226

Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           KA    FP      VTPEAK  I + L      RI   Q    P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
           isoform 1 [Homo sapiens]
          Length = 556

 Score =  105 bits (263), Expect = 1e-22
 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +    T  +  A KI    K + RD +K        RE RI 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
            ++++    I+H DLKP N+LL +      +K+ DFGL+          V G +    G 
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174

Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
           AGT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226

Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           KA    FP      VTPEAK  I + L      RI   Q    P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
           isoform 2 [Homo sapiens]
          Length = 527

 Score =  105 bits (263), Expect = 1e-22
 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +    T  +  A KI    K + RD +K        RE RI 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
            ++++    I+H DLKP N+LL +      +K+ DFGL+          V G +    G 
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174

Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
           AGT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226

Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           KA    FP      VTPEAK  I + L      RI   Q    P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|83776600 aurora kinase B [Homo sapiens]
          Length = 344

 Score =  105 bits (261), Expect = 2e-22
 Identities = 91/303 (30%), Positives = 147/303 (48%), Gaps = 38/303 (12%)

Query: 401 HPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACRE 460
           H T++D + +   LG+G F  VY A +      VA+K+  L K+    +KE       RE
Sbjct: 71  HFTIDD-FEIGRPLGKGKFGNVYLAREKKSHFIVALKV--LFKS--QIEKEGVEHQLRRE 125

Query: 461 YRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 520
             I   L HP I++LY+YF  D      +LEY    +L   L++     E+   +I+ ++
Sbjct: 126 IEIQAHLHHPNILRLYNYF-YDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 184

Query: 521 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELT 580
            +AL Y +  K  +IH D+KP N+LL      GE+KI DFG S          V    L 
Sbjct: 185 ADALMYCHGKK--VIHRDIKPENLLL---GLKGELKIADFGWS----------VHAPSLR 229

Query: 581 SQG-AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDI 636
            +   GT  YLPPE      E    + KVD+W +GV+ Y+ L G  PF    HN++ + I
Sbjct: 230 RKTMCGTLDYLPPEMI----EGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRI 285

Query: 637 LQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS 696
           ++        +++FP    V   A+  I + L +   +R+ + Q++  P++  + R+ + 
Sbjct: 286 VK-------VDLKFPAS--VPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLP 336

Query: 697 TSS 699
            S+
Sbjct: 337 PSA 339


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  104 bits (260), Expect = 2e-22
 Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +   + T Q Y A  I+    + RD +K        RE RI 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 584
            + +     I+H DLKP N+LL + +    +K+ DFGL+  +  D        +     A
Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175

Query: 585 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 644
           GT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +K
Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227

Query: 645 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           A    FP      VTPEAK  I + L      RI   +    P++
Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  104 bits (260), Expect = 2e-22
 Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%)

Query: 406 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 464
           D Y L   LG+G FS V +   + T Q Y A  I+    + RD +K        RE RI 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65

Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
           + L HP IV+L+D  S +   +  V +   G +L   +   +  SE +A   I QI+ ++
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124

Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 584
            + +     I+H DLKP N+LL + +    +K+ DFGL+  +  D        +     A
Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175

Query: 585 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 644
           GT  YL PE  V+ K+P      VD+W+ GVI Y  L G  PF  ++ Q  + Q+   +K
Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227

Query: 645 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
           A    FP      VTPEAK  I + L      RI   +    P++
Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,341,287
Number of Sequences: 37866
Number of extensions: 1313075
Number of successful extensions: 8436
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 261
Number of HSP's successfully gapped in prelim test: 855
Number of HSP's that attempted gapping in prelim test: 5687
Number of HSP's gapped (non-prelim): 2106
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press