BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] (718 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 1445 0.0 gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 1428 0.0 gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 1030 0.0 gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 1030 0.0 gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 970 0.0 gi|150456432 unc-51-like kinase 3 [Homo sapiens] 115 1e-25 gi|93004081 polo-like kinase 2 [Homo sapiens] 115 1e-25 gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 115 2e-25 gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 112 2e-24 gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 110 6e-24 gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 109 1e-23 gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 109 1e-23 gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 108 2e-23 gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 108 2e-23 gi|23308722 TTK protein kinase [Homo sapiens] 108 2e-23 gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 107 3e-23 gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 107 3e-23 gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 107 3e-23 gi|217330634 serine/threonine kinase 36 [Homo sapiens] 107 3e-23 gi|121114283 polo-like kinase 4 [Homo sapiens] 107 4e-23 gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 106 7e-23 gi|109255245 serine/threonine kinase 17a [Homo sapiens] 106 9e-23 gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22 gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22 gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22 gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22 gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22 gi|83776600 aurora kinase B [Homo sapiens] 105 2e-22 gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 104 2e-22 gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 104 2e-22 >gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] Length = 718 Score = 1445 bits (3740), Expect = 0.0 Identities = 718/718 (100%), Positives = 718/718 (100%) Query: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ Sbjct: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60 Query: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV 120 RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV Sbjct: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV 120 Query: 121 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL 180 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL Sbjct: 121 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL 180 Query: 181 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK 240 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK Sbjct: 181 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK 240 Query: 241 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR 300 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR Sbjct: 241 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR 300 Query: 301 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG 360 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG Sbjct: 301 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG 360 Query: 361 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS 420 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS Sbjct: 361 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS 420 Query: 421 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS Sbjct: 421 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480 Query: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK Sbjct: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540 Query: 541 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE 600 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE Sbjct: 541 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE 600 Query: 601 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 660 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA Sbjct: 601 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 660 Query: 661 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 718 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN Sbjct: 661 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 718 >gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] Length = 750 Score = 1428 bits (3697), Expect = 0.0 Identities = 718/750 (95%), Positives = 718/750 (95%), Gaps = 32/750 (4%) Query: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ Sbjct: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60 Query: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFE------------------------------- 89 RNRKRKAEPYETSQGKGTPRGHKISDYFE Sbjct: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 120 Query: 90 -RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 148 RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ Sbjct: 121 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 180 Query: 149 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 208 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR Sbjct: 181 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 240 Query: 209 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 268 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT Sbjct: 241 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 300 Query: 269 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 328 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ Sbjct: 301 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 360 Query: 329 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 388 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK Sbjct: 361 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 420 Query: 389 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 448 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE Sbjct: 421 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 480 Query: 449 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 508 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM Sbjct: 481 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 540 Query: 509 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 568 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD Sbjct: 541 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 600 Query: 569 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 628 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG Sbjct: 601 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 660 Query: 629 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL Sbjct: 661 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720 Query: 689 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 718 PHIRKSVSTSSPAGAAIASTSGASNNSSSN Sbjct: 721 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 750 >gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] Length = 718 Score = 1030 bits (2662), Expect = 0.0 Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%) Query: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49 M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE Sbjct: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60 Query: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103 ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ + Sbjct: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120 Query: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163 + P+ S + NSPS T +H Sbjct: 121 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 153 Query: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223 KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+ Sbjct: 154 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 211 Query: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283 LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG Sbjct: 212 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 271 Query: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340 +AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN Sbjct: 272 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 331 Query: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391 + LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+ Sbjct: 332 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 391 Query: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451 NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE Sbjct: 392 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 451 Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK Sbjct: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 511 Query: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571 EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY Sbjct: 512 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 571 Query: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631 VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ Sbjct: 572 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 630 Query: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691 SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+ Sbjct: 631 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 690 Query: 692 RKSVSTSS--PAGAAIASTSGASN 713 R+S S+ + AG + T +S+ Sbjct: 691 RRSNSSGNLHMAGLTASPTPPSSS 714 >gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] Length = 766 Score = 1030 bits (2662), Expect = 0.0 Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%) Query: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49 M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE Sbjct: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108 Query: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103 ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ + Sbjct: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168 Query: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163 + P+ S + NSPS T +H Sbjct: 169 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 201 Query: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223 KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+ Sbjct: 202 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 259 Query: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283 LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG Sbjct: 260 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 319 Query: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340 +AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN Sbjct: 320 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 379 Query: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391 + LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+ Sbjct: 380 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 439 Query: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451 NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE Sbjct: 440 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 499 Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK Sbjct: 500 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 559 Query: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571 EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY Sbjct: 560 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 619 Query: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631 VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ Sbjct: 620 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 678 Query: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691 SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+ Sbjct: 679 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738 Query: 692 RKSVSTSS--PAGAAIASTSGASN 713 R+S S+ + AG + T +S+ Sbjct: 739 RRSNSSGNLHMAGLTASPTPPSSS 762 >gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] Length = 670 Score = 970 bits (2507), Expect = 0.0 Identities = 507/683 (74%), Positives = 558/683 (81%), Gaps = 50/683 (7%) Query: 51 ETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSAA 104 +TPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ + Sbjct: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73 Query: 105 KEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCS 164 + P+ S + NSPS T +H Sbjct: 74 SPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPIV 106 Query: 165 SQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKML 224 KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+L Sbjct: 107 QPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLL 164 Query: 225 EKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGY 284 EKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG+ Sbjct: 165 EKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGF 224 Query: 285 AFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAENE 341 AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN+ Sbjct: 225 AFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEND 284 Query: 342 T---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHN 392 LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+N Sbjct: 285 PFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINN 344 Query: 393 EDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKEN 452 EDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKEN Sbjct: 345 EDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKEN 404 Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512 YHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEKE Sbjct: 405 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 464 Query: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572 ARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY Sbjct: 465 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 524 Query: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632 VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQS Sbjct: 525 -VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQS 583 Query: 633 QQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIR 692 QQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+R Sbjct: 584 QQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMR 643 Query: 693 KSVSTSS--PAGAAIASTSGASN 713 +S S+ + AG + T +S+ Sbjct: 644 RSNSSGNLHMAGLTASPTPPSSS 666 >gi|150456432 unc-51-like kinase 3 [Homo sapiens] Length = 472 Score = 115 bits (289), Expect = 1e-25 Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 25/287 (8%) Query: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461 P D ++L LG G ++ VYKA+ + R V K+ EN E Sbjct: 8 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63 Query: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521 I K + HP IV+L D F D+D+ ++E+C G DL ++ +++ EK AR + Q+ Sbjct: 64 EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122 Query: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD-DSYNSVDGMELT 580 +AL++L+E I H DLKP NILL + +K+ DFG ++ M D + + G L Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178 Query: 581 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640 Y+ PE + +VD+WS+GVI Y+ L+G+ PF + E Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223 Query: 641 TILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 I ++ P +P+++ + + ++R L RI Q P++ Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 270 >gi|93004081 polo-like kinase 2 [Homo sapiens] Length = 685 Score = 115 bits (289), Expect = 1e-25 Identities = 89/292 (30%), Positives = 136/292 (46%), Gaps = 37/292 (12%) Query: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461 PT RY +LG+GGF++ Y+ DLT + A KI ++ + ++E K E Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131 Query: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521 +H+ L H +V+ Y YF D ++ +LEYC + LK K+++E E R + QIV Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190 Query: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTS 581 + LKYL+E I+H DLK GN + E+K+ DFGL+ ++ + Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFI---NEAMELKVGDFGLAARLEPLEHR-------RR 238 Query: 582 QGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT 641 GT YL PE V+ K+ + D+W++G + Y L GR PF E T Sbjct: 239 TICGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETT 283 Query: 642 ILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688 LK T E ++ + AK I L+ EDR + + + L Sbjct: 284 NLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335 >gi|4507831 Unc-51-like kinase 1 [Homo sapiens] Length = 1050 Score = 115 bits (287), Expect = 2e-25 Identities = 97/317 (30%), Positives = 148/317 (46%), Gaps = 37/317 (11%) Query: 413 LLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRI 472 L+G G F+ V+K E+ + V + +NK + + K E +I KEL H I Sbjct: 21 LIGHGAFAVVFKGRH-REKHDLEVAVKCINKKNLAKSQTLLGK----EIKILKELKHENI 75 Query: 473 VKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKP 532 V LYD+ + +S V+EYC G DL YL + +SE R + QI A++ L+ Sbjct: 76 VALYDFQEM-ANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS--K 132 Query: 533 PIIHYDLKPGNILLVNGTACG------EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGT 586 IIH DLKP NILL N +KI DFG ++ + + + + G+ Sbjct: 133 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM--------MAATLCGS 184 Query: 587 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI---LQENTIL 643 Y+ PE + K D+WS+G I YQCL G+ PF S QD+ ++N L Sbjct: 185 PMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNKTL 239 Query: 644 KATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL--LPHIRKSVSTSSPA 701 T P+ P + + L +DR+D + P+L P +RKS P+ Sbjct: 240 VPT----IPRETSAP-LRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPS 294 Query: 702 GAAIASTSGASNNSSSN 718 + S S +S++S+S+ Sbjct: 295 YPSSGSGSSSSSSSTSH 311 >gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] Length = 661 Score = 112 bits (279), Expect = 2e-24 Identities = 90/296 (30%), Positives = 140/296 (47%), Gaps = 36/296 (12%) Query: 387 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 446 +KR H++ N L RY L LG+G + +V +A + R VA+K + +K Sbjct: 42 VKRHHHKHN--------LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI-- 91 Query: 447 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 506 K E H RE I L+HP I+ +Y+ F + D ++EY +L Y+ + + Sbjct: 92 --KDEQDMVHIRREIEIMSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERR 148 Query: 507 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 566 +SE+E R QIV+A+ Y + K ++H DLK NILL + IKI DFGLS + Sbjct: 149 RLSERETRHFFRQIVSAVHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLY 203 Query: 567 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 626 D + G+ Y PE V G+ P +VD W++GV+ Y +YG P Sbjct: 204 QKDKF--------LQTFCGSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMP 252 Query: 627 FGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 682 F + I Q + + E + P +P +A+ IR L + R ++ +A Sbjct: 253 FDGFDHKNLIRQ----ISSGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIA 301 >gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo sapiens] Length = 370 Score = 110 bits (274), Expect = 6e-24 Identities = 96/311 (30%), Positives = 154/311 (49%), Gaps = 33/311 (10%) Query: 394 DNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK-IHQLNKNWRDEKKEN 452 + ++K + D Y +LG G FSEV A D Q+ VA+K I + ++ EN Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65 Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512 E + ++ HP IV L D + + +++ G +L + + +E++ Sbjct: 66 -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117 Query: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572 A +I Q+++A+KYL+++ I+H DLKP N+L + +I I+DFGLSK+ D S Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173 Query: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632 + S GT Y+ PE V+ ++P S VD WS+GVI Y L G PF ++++ Sbjct: 174 ------VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEN 222 Query: 633 QQDILQENTILKAT-EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQ------LACDP 685 + ++ ILKA E P ++ AK FIR + E R +Q +A D Sbjct: 223 DAKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDT 280 Query: 686 YLLPHIRKSVS 696 L +I +SVS Sbjct: 281 ALDKNIHQSVS 291 >gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] Length = 586 Score = 109 bits (272), Expect = 1e-23 Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%) Query: 404 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 462 L D Y++ LG G EV AF+ + VA+KI K +E + + E Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318 Query: 463 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 522 I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++ Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376 Query: 523 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 582 A++YL+E IIH DLKP N+LL + IKITDFG SKI+ + S L Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 426 Query: 583 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 642 GT YL PE +V + VD WS+GVI + CL G PF +++Q + + T Sbjct: 427 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 484 Query: 643 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 + + F P+ V+ +A +++ L + R ++ P+L Sbjct: 485 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529 >gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] Length = 543 Score = 109 bits (272), Expect = 1e-23 Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%) Query: 404 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 462 L D Y++ LG G EV AF+ + VA+KI K +E + + E Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275 Query: 463 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 522 I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++ Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333 Query: 523 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 582 A++YL+E IIH DLKP N+LL + IKITDFG SKI+ + S L Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 383 Query: 583 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 642 GT YL PE +V + VD WS+GVI + CL G PF +++Q + + T Sbjct: 384 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 441 Query: 643 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 + + F P+ V+ +A +++ L + R ++ P+L Sbjct: 442 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486 >gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] Length = 628 Score = 108 bits (270), Expect = 2e-23 Identities = 96/297 (32%), Positives = 143/297 (48%), Gaps = 39/297 (13%) Query: 387 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 446 +KR H++ N L RY L LG+G + +V KA + + R VA+K + +K Sbjct: 40 VKRHHHKHN--------LRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKI-- 88 Query: 447 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 506 K E H RE I L+HP I+ +++ F ++ V+EY DL Y+ + + Sbjct: 89 --KDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE-NSSKIVIVMEYASRGDLYDYISERQ 145 Query: 507 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 566 +SE+EAR QIV+A+ Y ++ + ++H DLK NILL A G IKI DFGLS + Sbjct: 146 QLSEREARHFFRQIVSAVHYCHQNR--VVHRDLKLENILL---DANGNIKIADFGLSNLY 200 Query: 567 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 626 + G+ Y PE V GK P +VD WS+GV+ Y ++G P Sbjct: 201 HQGKF--------LQTFCGSPLYASPE-IVNGK--PYTGPEVDSWSLGVLLYILVHGTMP 249 Query: 627 F-GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 682 F GH+ IL + + + PPKP +A IR L R ++ +A Sbjct: 250 FDGHDHK---ILVKQ--ISNGAYREPPKP---SDACGLIRWLLMVNPTRRATLEDVA 298 >gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo sapiens] Length = 476 Score = 108 bits (270), Expect = 2e-23 Identities = 88/300 (29%), Positives = 142/300 (47%), Gaps = 26/300 (8%) Query: 389 RIHNEDNSQFKDHPT-LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRD 447 R +D S +K T + ++ + +LG G FSEV+ + A+K + + +RD Sbjct: 3 RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62 Query: 448 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL 507 EN E + K++ H IV L D + T + V++ G +L + + + Sbjct: 63 SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114 Query: 508 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 567 +EK+A +I Q+++A+KYL+E I+H DLKP N+L + +I ITDFGLSK+ Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172 Query: 568 DDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 627 + + S GT Y+ PE V+ ++P S VD WS+GVI Y L G PF Sbjct: 173 NG---------IMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF 219 Query: 628 GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 + + L E E + P ++ AK FI L +R ++ P++ Sbjct: 220 --YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277 >gi|23308722 TTK protein kinase [Homo sapiens] Length = 857 Score = 108 bits (269), Expect = 2e-23 Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 37/292 (12%) Query: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467 Y +L +G GG S+V++ + +Q Y A+K L + ++ ++Y ++ + Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582 Query: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527 D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ + Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638 Query: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587 ++ I+H DLKP N L+V+G +K+ DFG++ M D+ + V ++ GT Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSVVKDSQV-----GTV 687 Query: 588 WYLPPECFVV-------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640 Y+PPE GK KIS K DVWS+G I Y YG+ PF Q I+ + Sbjct: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQI 741 Query: 641 TILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 + L A E++FP P + + ++ CL + RI + +L PY+ Sbjct: 742 SKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791 >gi|62865643 aurora kinase C isoform 3 [Homo sapiens] Length = 275 Score = 107 bits (268), Expect = 3e-23 Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%) Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473 LG+G F VY A VA+K+ L K+ +KE RE I L HP I+ Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70 Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533 +LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K Sbjct: 71 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127 Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593 +IH D+KP N+LL GE+KI DFG S ++ GT YLPPE Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 175 Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650 E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F Sbjct: 176 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 224 Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693 P + A+ I R L Y+ +R+ + Q+ P++ H R+ Sbjct: 225 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265 >gi|62865641 aurora kinase C isoform 2 [Homo sapiens] Length = 290 Score = 107 bits (268), Expect = 3e-23 Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%) Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473 LG+G F VY A VA+K+ L K+ +KE RE I L HP I+ Sbjct: 30 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85 Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533 +LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K Sbjct: 86 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142 Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593 +IH D+KP N+LL GE+KI DFG S ++ GT YLPPE Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 190 Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650 E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F Sbjct: 191 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 239 Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693 P + A+ I R L Y+ +R+ + Q+ P++ H R+ Sbjct: 240 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280 >gi|62865639 aurora kinase C isoform 1 [Homo sapiens] Length = 309 Score = 107 bits (268), Expect = 3e-23 Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%) Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473 LG+G F VY A VA+K+ L K+ +KE RE I L HP I+ Sbjct: 49 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104 Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533 +LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161 Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593 +IH D+KP N+LL GE+KI DFG S ++ GT YLPPE Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 209 Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650 E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F Sbjct: 210 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 258 Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693 P + A+ I R L Y+ +R+ + Q+ P++ H R+ Sbjct: 259 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299 >gi|217330634 serine/threonine kinase 36 [Homo sapiens] Length = 1315 Score = 107 bits (268), Expect = 3e-23 Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 29/295 (9%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHK 465 ++Y +L ++G G F VYK + VA+K + K R EK+ ++ RE I + Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKEL---RNLQREIEIMR 56 Query: 466 ELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALK 525 L HP IV + D F D + V +Y EG +L L+ + E + ++I Q+V+AL Sbjct: 57 GLRHPNIVHMLDSFETDKE-VVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114 Query: 526 YLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 585 YL+ + I+H D+KP NILL G G IK+ DFG ++ M S + M LTS G Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAM------STNTMVLTSI-KG 162 Query: 586 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKA 645 T Y+ PE +V + P + D+WSVG I Y+ G PF I Q +++ Sbjct: 163 TPLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILK 214 Query: 646 TEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSP 700 V++P ++P K F++ L R+ L P++ H+ + P Sbjct: 215 DPVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGP 267 >gi|121114283 polo-like kinase 4 [Homo sapiens] Length = 970 Score = 107 bits (267), Expect = 4e-23 Identities = 93/316 (29%), Positives = 148/316 (46%), Gaps = 40/316 (12%) Query: 412 HLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPR 471 +LLG+G F+ VY+A + VA+K+ + K + E +IH +L HP Sbjct: 16 NLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHCQLKHPS 71 Query: 472 IVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIIMQIVNALKYLNEI 530 I++LY+YF D++ VLE C +++ YLK K SE EAR + QI+ + YL+ Sbjct: 72 ILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS- 129 Query: 531 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLS---KIMDDDSYNSVDGMELTSQGAGTY 587 I+H DL N+LL IKI DFGL+ K+ + Y GT Sbjct: 130 -HGILHRDLTLSNLLLTRNM---NIKIADFGLATQLKMPHEKHYTL----------CGTP 175 Query: 588 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE 647 Y+ PE + + + + DVWS+G +FY L GR PF + +NT+ K Sbjct: 176 NYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTLNKVVL 225 Query: 648 VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK------SVSTSSPA 701 + ++ EAK I + L DR+ + + P++ + +V S + Sbjct: 226 ADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDS 285 Query: 702 GAAIASTSGASNNSSS 717 G A ST+ +++S+S Sbjct: 286 GHATISTAITASSSTS 301 >gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo sapiens] Length = 688 Score = 106 bits (265), Expect = 7e-23 Identities = 89/281 (31%), Positives = 133/281 (47%), Gaps = 30/281 (10%) Query: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467 Y LL +G+G F++V A + R VA+KI + + + + RE RI K L Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPSSLQKLFREVRIMKGL 113 Query: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527 +HP IVKL++ + + V+EY ++ YL H M EKEAR+ QIV+A+ Y Sbjct: 114 NHPNIVKLFEVIETEKTLYL-VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 172 Query: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587 ++ I+H DLK N+LL A IKI DFG S N G+ Sbjct: 173 HQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS--------NEFTLGSKLDTFCGSP 219 Query: 588 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTILKAT 646 Y PE F K +VD+WS+GVI Y + G PF GHN + L+E + Sbjct: 220 PYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRGKY 273 Query: 647 EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 V F ++ + ++ +RR L R ++Q+ D ++ Sbjct: 274 RVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310 >gi|109255245 serine/threonine kinase 17a [Homo sapiens] Length = 414 Score = 106 bits (264), Expect = 9e-23 Identities = 84/277 (30%), Positives = 138/277 (49%), Gaps = 25/277 (9%) Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473 LGRG F+ V K + A K + + +D + E H+ A E D+P ++ Sbjct: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELA----QDNPWVI 122 Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDL--DFYLKQHKLMSEKEARSIIMQIVNALKYLNEIK 531 L++ + ++ VLEY G ++ + + EK+ + ++ QI+ + +L+ Sbjct: 123 NLHEVYETASEMIL-VLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHT-- 179 Query: 532 PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLP 591 ++H DLKP NILL + + G+IKI DFGLS+I+ NS + E+ GT Y+ Sbjct: 180 RDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILK----NSEELREI----MGTPEYVA 231 Query: 592 PECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI-LKATEVQF 650 PE ++ +P IS D+WS+GV+ Y L G PF N Q+ L + + L +E +F Sbjct: 232 PE--ILSYDP--ISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEF 287 Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 V++ A FIR L + EDR ++ P+L Sbjct: 288 ---DVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321 >gi|26667199 calcium/calmodulin-dependent protein kinase II gamma isoform 3 [Homo sapiens] Length = 518 Score = 105 bits (263), Expect = 1e-22 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + T + A KI K + RD +K RE RI Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583 ++++ I+H DLKP N+LL + +K+ DFGL+ V G + G Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174 Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643 AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ + Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226 Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 KA FP VTPEAK I + L RI Q P++ Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272 >gi|26667191 calcium/calmodulin-dependent protein kinase II gamma isoform 4 [Homo sapiens] Length = 495 Score = 105 bits (263), Expect = 1e-22 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + T + A KI K + RD +K RE RI Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583 ++++ I+H DLKP N+LL + +K+ DFGL+ V G + G Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174 Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643 AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ + Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226 Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 KA FP VTPEAK I + L RI Q P++ Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272 >gi|26667211 calcium/calmodulin-dependent protein kinase II gamma isoform 6 [Homo sapiens] Length = 504 Score = 105 bits (263), Expect = 1e-22 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + T + A KI K + RD +K RE RI Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583 ++++ I+H DLKP N+LL + +K+ DFGL+ V G + G Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174 Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643 AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ + Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226 Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 KA FP VTPEAK I + L RI Q P++ Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272 >gi|26667203 calcium/calmodulin-dependent protein kinase II gamma isoform 1 [Homo sapiens] Length = 556 Score = 105 bits (263), Expect = 1e-22 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + T + A KI K + RD +K RE RI Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583 ++++ I+H DLKP N+LL + +K+ DFGL+ V G + G Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174 Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643 AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ + Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226 Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 KA FP VTPEAK I + L RI Q P++ Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272 >gi|26667196 calcium/calmodulin-dependent protein kinase II gamma isoform 2 [Homo sapiens] Length = 527 Score = 105 bits (263), Expect = 1e-22 Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + T + A KI K + RD +K RE RI Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583 ++++ I+H DLKP N+LL + +K+ DFGL+ V G + G Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174 Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643 AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ + Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226 Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 KA FP VTPEAK I + L RI Q P++ Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272 >gi|83776600 aurora kinase B [Homo sapiens] Length = 344 Score = 105 bits (261), Expect = 2e-22 Identities = 91/303 (30%), Positives = 147/303 (48%), Gaps = 38/303 (12%) Query: 401 HPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACRE 460 H T++D + + LG+G F VY A + VA+K+ L K+ +KE RE Sbjct: 71 HFTIDD-FEIGRPLGKGKFGNVYLAREKKSHFIVALKV--LFKS--QIEKEGVEHQLRRE 125 Query: 461 YRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 520 I L HP I++LY+YF D +LEY +L L++ E+ +I+ ++ Sbjct: 126 IEIQAHLHHPNILRLYNYF-YDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 184 Query: 521 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELT 580 +AL Y + K +IH D+KP N+LL GE+KI DFG S V L Sbjct: 185 ADALMYCHGKK--VIHRDIKPENLLL---GLKGELKIADFGWS----------VHAPSLR 229 Query: 581 SQG-AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDI 636 + GT YLPPE E + KVD+W +GV+ Y+ L G PF HN++ + I Sbjct: 230 RKTMCGTLDYLPPEMI----EGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRI 285 Query: 637 LQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS 696 ++ +++FP V A+ I + L + +R+ + Q++ P++ + R+ + Sbjct: 286 VK-------VDLKFPAS--VPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLP 336 Query: 697 TSS 699 S+ Sbjct: 337 PSA 339 >gi|212549756 calcium/calmodulin-dependent protein kinase II delta isoform 4 [Homo sapiens] Length = 489 Score = 104 bits (260), Expect = 2e-22 Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + + T Q Y A I+ + RD +K RE RI Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 584 + + I+H DLKP N+LL + + +K+ DFGL+ + D + A Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175 Query: 585 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 644 GT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +K Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227 Query: 645 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 A FP VTPEAK I + L RI + P++ Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272 >gi|26667183 calcium/calmodulin-dependent protein kinase II delta isoform 1 [Homo sapiens] Length = 478 Score = 104 bits (260), Expect = 2e-22 Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%) Query: 406 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 464 D Y L LG+G FS V + + T Q Y A I+ + RD +K RE RI Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65 Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524 + L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++ Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124 Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 584 + + I+H DLKP N+LL + + +K+ DFGL+ + D + A Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175 Query: 585 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 644 GT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +K Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227 Query: 645 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687 A FP VTPEAK I + L RI + P++ Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.131 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,341,287 Number of Sequences: 37866 Number of extensions: 1313075 Number of successful extensions: 8436 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 261 Number of HSP's successfully gapped in prelim test: 855 Number of HSP's that attempted gapping in prelim test: 5687 Number of HSP's gapped (non-prelim): 2106 length of query: 718 length of database: 18,247,518 effective HSP length: 110 effective length of query: 608 effective length of database: 14,082,258 effective search space: 8562012864 effective search space used: 8562012864 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.