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Search of human proteins with 162951881
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
(718 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 1445 0.0
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 1428 0.0
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 1030 0.0
gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 1030 0.0
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 970 0.0
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 115 1e-25
gi|93004081 polo-like kinase 2 [Homo sapiens] 115 1e-25
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 115 2e-25
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 112 2e-24
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 110 6e-24
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 109 1e-23
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 109 1e-23
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 108 2e-23
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 108 2e-23
gi|23308722 TTK protein kinase [Homo sapiens] 108 2e-23
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 107 3e-23
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 107 3e-23
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 107 3e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 107 3e-23
gi|121114283 polo-like kinase 4 [Homo sapiens] 107 4e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 106 7e-23
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 106 9e-23
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|83776600 aurora kinase B [Homo sapiens] 105 2e-22
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 104 2e-22
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 104 2e-22
>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
Length = 718
Score = 1445 bits (3740), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
Sbjct: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
Query: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV 120
RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV
Sbjct: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSV 120
Query: 121 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL 180
MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
Sbjct: 121 MLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL 180
Query: 181 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK 240
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK
Sbjct: 181 TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK 240
Query: 241 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR 300
LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR
Sbjct: 241 LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQR 300
Query: 301 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG 360
EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
Sbjct: 301 EEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG 360
Query: 361 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS 420
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS
Sbjct: 361 HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFS 420
Query: 421 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480
EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS
Sbjct: 421 EVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480
Query: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540
LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
Sbjct: 481 LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK 540
Query: 541 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE 600
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE
Sbjct: 541 PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKE 600
Query: 601 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 660
PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA
Sbjct: 601 PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 660
Query: 661 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 718
KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
Sbjct: 661 KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 718
>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
Length = 750
Score = 1428 bits (3697), Expect = 0.0
Identities = 718/750 (95%), Positives = 718/750 (95%), Gaps = 32/750 (4%)
Query: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
Sbjct: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
Query: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFE------------------------------- 89
RNRKRKAEPYETSQGKGTPRGHKISDYFE
Sbjct: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 120
Query: 90 -RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 148
RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
Sbjct: 121 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 180
Query: 149 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 208
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
Sbjct: 181 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 240
Query: 209 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 268
ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT
Sbjct: 241 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 300
Query: 269 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 328
TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
Sbjct: 301 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 360
Query: 329 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 388
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK
Sbjct: 361 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 420
Query: 389 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 448
RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE
Sbjct: 421 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 480
Query: 449 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 508
KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
Sbjct: 481 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 540
Query: 509 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 568
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD
Sbjct: 541 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 600
Query: 569 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 628
DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG
Sbjct: 601 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 660
Query: 629 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688
HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL
Sbjct: 661 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720
Query: 689 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 718
PHIRKSVSTSSPAGAAIASTSGASNNSSSN
Sbjct: 721 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 750
>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
Length = 718
Score = 1030 bits (2662), Expect = 0.0
Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%)
Query: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE
Sbjct: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
Query: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103
ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ +
Sbjct: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120
Query: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163
+ P+ S + NSPS T +H
Sbjct: 121 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 153
Query: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223
KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+
Sbjct: 154 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 211
Query: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283
LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG
Sbjct: 212 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 271
Query: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340
+AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN
Sbjct: 272 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 331
Query: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391
+ LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+
Sbjct: 332 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 391
Query: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451
NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE
Sbjct: 392 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 451
Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511
NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK
Sbjct: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 511
Query: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571
EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 512 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 571
Query: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631
VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ
Sbjct: 572 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 630
Query: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+
Sbjct: 631 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 690
Query: 692 RKSVSTSS--PAGAAIASTSGASN 713
R+S S+ + AG + T +S+
Sbjct: 691 RRSNSSGNLHMAGLTASPTPPSSS 714
>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
Length = 766
Score = 1030 bits (2662), Expect = 0.0
Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%)
Query: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE
Sbjct: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108
Query: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103
ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ +
Sbjct: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168
Query: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163
+ P+ S + NSPS T +H
Sbjct: 169 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 201
Query: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223
KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+
Sbjct: 202 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 259
Query: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283
LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG
Sbjct: 260 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 319
Query: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340
+AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN
Sbjct: 320 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 379
Query: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391
+ LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+
Sbjct: 380 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 439
Query: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451
NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE
Sbjct: 440 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 499
Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511
NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK
Sbjct: 500 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 559
Query: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571
EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 560 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 619
Query: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631
VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ
Sbjct: 620 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 678
Query: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+
Sbjct: 679 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738
Query: 692 RKSVSTSS--PAGAAIASTSGASN 713
R+S S+ + AG + T +S+
Sbjct: 739 RRSNSSGNLHMAGLTASPTPPSSS 762
>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
Length = 670
Score = 970 bits (2507), Expect = 0.0
Identities = 507/683 (74%), Positives = 558/683 (81%), Gaps = 50/683 (7%)
Query: 51 ETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSAA 104
+TPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ +
Sbjct: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73
Query: 105 KEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCS 164
+ P+ S + NSPS T +H
Sbjct: 74 SPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPIV 106
Query: 165 SQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKML 224
KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+L
Sbjct: 107 QPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLL 164
Query: 225 EKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGY 284
EKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG+
Sbjct: 165 EKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGF 224
Query: 285 AFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAENE 341
AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN+
Sbjct: 225 AFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEND 284
Query: 342 T---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHN 392
LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+N
Sbjct: 285 PFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINN 344
Query: 393 EDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKEN 452
EDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKEN
Sbjct: 345 EDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKEN 404
Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512
YHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEKE
Sbjct: 405 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 464
Query: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572
ARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 465 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 524
Query: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632
VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQS
Sbjct: 525 -VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQS 583
Query: 633 QQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIR 692
QQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+R
Sbjct: 584 QQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMR 643
Query: 693 KSVSTSS--PAGAAIASTSGASN 713
+S S+ + AG + T +S+
Sbjct: 644 RSNSSGNLHMAGLTASPTPPSSS 666
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 115 bits (289), Expect = 1e-25
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 25/287 (8%)
Query: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461
P D ++L LG G ++ VYKA+ + R V K+ EN E
Sbjct: 8 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63
Query: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521
I K + HP IV+L D F D+D+ ++E+C G DL ++ +++ EK AR + Q+
Sbjct: 64 EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122
Query: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD-DSYNSVDGMELT 580
+AL++L+E I H DLKP NILL + +K+ DFG ++ M D + + G L
Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178
Query: 581 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640
Y+ PE + +VD+WS+GVI Y+ L+G+ PF + E
Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223
Query: 641 TILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
I ++ P +P+++ + + ++R L RI Q P++
Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 270
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 115 bits (289), Expect = 1e-25
Identities = 89/292 (30%), Positives = 136/292 (46%), Gaps = 37/292 (12%)
Query: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461
PT RY +LG+GGF++ Y+ DLT + A KI ++ + ++E K E
Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131
Query: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521
+H+ L H +V+ Y YF D ++ +LEYC + LK K+++E E R + QIV
Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190
Query: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTS 581
+ LKYL+E I+H DLK GN + E+K+ DFGL+ ++ +
Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFI---NEAMELKVGDFGLAARLEPLEHR-------RR 238
Query: 582 QGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT 641
GT YL PE V+ K+ + D+W++G + Y L GR PF E T
Sbjct: 239 TICGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETT 283
Query: 642 ILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688
LK T E ++ + AK I L+ EDR + + + L
Sbjct: 284 NLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 115 bits (287), Expect = 2e-25
Identities = 97/317 (30%), Positives = 148/317 (46%), Gaps = 37/317 (11%)
Query: 413 LLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRI 472
L+G G F+ V+K E+ + V + +NK + + K E +I KEL H I
Sbjct: 21 LIGHGAFAVVFKGRH-REKHDLEVAVKCINKKNLAKSQTLLGK----EIKILKELKHENI 75
Query: 473 VKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKP 532
V LYD+ + +S V+EYC G DL YL + +SE R + QI A++ L+
Sbjct: 76 VALYDFQEM-ANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS--K 132
Query: 533 PIIHYDLKPGNILLVNGTACG------EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGT 586
IIH DLKP NILL N +KI DFG ++ + + + + G+
Sbjct: 133 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM--------MAATLCGS 184
Query: 587 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI---LQENTIL 643
Y+ PE + K D+WS+G I YQCL G+ PF S QD+ ++N L
Sbjct: 185 PMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNKTL 239
Query: 644 KATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL--LPHIRKSVSTSSPA 701
T P+ P + + L +DR+D + P+L P +RKS P+
Sbjct: 240 VPT----IPRETSAP-LRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPS 294
Query: 702 GAAIASTSGASNNSSSN 718
+ S S +S++S+S+
Sbjct: 295 YPSSGSGSSSSSSSTSH 311
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 112 bits (279), Expect = 2e-24
Identities = 90/296 (30%), Positives = 140/296 (47%), Gaps = 36/296 (12%)
Query: 387 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 446
+KR H++ N L RY L LG+G + +V +A + R VA+K + +K
Sbjct: 42 VKRHHHKHN--------LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI-- 91
Query: 447 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 506
K E H RE I L+HP I+ +Y+ F + D ++EY +L Y+ + +
Sbjct: 92 --KDEQDMVHIRREIEIMSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERR 148
Query: 507 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 566
+SE+E R QIV+A+ Y + K ++H DLK NILL + IKI DFGLS +
Sbjct: 149 RLSERETRHFFRQIVSAVHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLY 203
Query: 567 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 626
D + G+ Y PE V G+ P +VD W++GV+ Y +YG P
Sbjct: 204 QKDKF--------LQTFCGSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMP 252
Query: 627 FGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 682
F + I Q + + E + P +P +A+ IR L + R ++ +A
Sbjct: 253 FDGFDHKNLIRQ----ISSGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIA 301
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 110 bits (274), Expect = 6e-24
Identities = 96/311 (30%), Positives = 154/311 (49%), Gaps = 33/311 (10%)
Query: 394 DNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK-IHQLNKNWRDEKKEN 452
+ ++K + D Y +LG G FSEV A D Q+ VA+K I + ++ EN
Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65
Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512
E + ++ HP IV L D + + +++ G +L + + +E++
Sbjct: 66 -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117
Query: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572
A +I Q+++A+KYL+++ I+H DLKP N+L + +I I+DFGLSK+ D S
Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173
Query: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632
+ S GT Y+ PE V+ ++P S VD WS+GVI Y L G PF ++++
Sbjct: 174 ------VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEN 222
Query: 633 QQDILQENTILKAT-EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQ------LACDP 685
+ ++ ILKA E P ++ AK FIR + E R +Q +A D
Sbjct: 223 DAKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDT 280
Query: 686 YLLPHIRKSVS 696
L +I +SVS
Sbjct: 281 ALDKNIHQSVS 291
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 109 bits (272), Expect = 1e-23
Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%)
Query: 404 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 462
L D Y++ LG G EV AF+ + VA+KI K +E + + E
Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318
Query: 463 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 522
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376
Query: 523 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 582
A++YL+E IIH DLKP N+LL + IKITDFG SKI+ + S L
Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 426
Query: 583 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 642
GT YL PE +V + VD WS+GVI + CL G PF +++Q + + T
Sbjct: 427 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 484
Query: 643 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
+ + F P+ V+ +A +++ L + R ++ P+L
Sbjct: 485 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 109 bits (272), Expect = 1e-23
Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%)
Query: 404 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 462
L D Y++ LG G EV AF+ + VA+KI K +E + + E
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
Query: 463 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 522
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333
Query: 523 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 582
A++YL+E IIH DLKP N+LL + IKITDFG SKI+ + S L
Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 383
Query: 583 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 642
GT YL PE +V + VD WS+GVI + CL G PF +++Q + + T
Sbjct: 384 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 441
Query: 643 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
+ + F P+ V+ +A +++ L + R ++ P+L
Sbjct: 442 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 108 bits (270), Expect = 2e-23
Identities = 96/297 (32%), Positives = 143/297 (48%), Gaps = 39/297 (13%)
Query: 387 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 446
+KR H++ N L RY L LG+G + +V KA + + R VA+K + +K
Sbjct: 40 VKRHHHKHN--------LRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKI-- 88
Query: 447 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 506
K E H RE I L+HP I+ +++ F ++ V+EY DL Y+ + +
Sbjct: 89 --KDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE-NSSKIVIVMEYASRGDLYDYISERQ 145
Query: 507 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 566
+SE+EAR QIV+A+ Y ++ + ++H DLK NILL A G IKI DFGLS +
Sbjct: 146 QLSEREARHFFRQIVSAVHYCHQNR--VVHRDLKLENILL---DANGNIKIADFGLSNLY 200
Query: 567 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 626
+ G+ Y PE V GK P +VD WS+GV+ Y ++G P
Sbjct: 201 HQGKF--------LQTFCGSPLYASPE-IVNGK--PYTGPEVDSWSLGVLLYILVHGTMP 249
Query: 627 F-GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 682
F GH+ IL + + + PPKP +A IR L R ++ +A
Sbjct: 250 FDGHDHK---ILVKQ--ISNGAYREPPKP---SDACGLIRWLLMVNPTRRATLEDVA 298
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 108 bits (270), Expect = 2e-23
Identities = 88/300 (29%), Positives = 142/300 (47%), Gaps = 26/300 (8%)
Query: 389 RIHNEDNSQFKDHPT-LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRD 447
R +D S +K T + ++ + +LG G FSEV+ + A+K + + +RD
Sbjct: 3 RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62
Query: 448 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL 507
EN E + K++ H IV L D + T + V++ G +L + + +
Sbjct: 63 SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114
Query: 508 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 567
+EK+A +I Q+++A+KYL+E I+H DLKP N+L + +I ITDFGLSK+
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172
Query: 568 DDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 627
+ + S GT Y+ PE V+ ++P S VD WS+GVI Y L G PF
Sbjct: 173 NG---------IMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF 219
Query: 628 GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
+ + L E E + P ++ AK FI L +R ++ P++
Sbjct: 220 --YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>gi|23308722 TTK protein kinase [Homo sapiens]
Length = 857
Score = 108 bits (269), Expect = 2e-23
Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 37/292 (12%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467
Y +L +G GG S+V++ + +Q Y A+K L + ++ ++Y ++ +
Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Query: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
Query: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587
++ I+H DLKP N L+V+G +K+ DFG++ M D+ + V ++ GT
Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSVVKDSQV-----GTV 687
Query: 588 WYLPPECFVV-------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640
Y+PPE GK KIS K DVWS+G I Y YG+ PF Q I+ +
Sbjct: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQI 741
Query: 641 TILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
+ L A E++FP P + + ++ CL + RI + +L PY+
Sbjct: 742 SKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 107 bits (268), Expect = 3e-23
Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)
Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
LG+G F VY A VA+K+ L K+ +KE RE I L HP I+
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70
Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533
+LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K
Sbjct: 71 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127
Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593
+IH D+KP N+LL GE+KI DFG S ++ GT YLPPE
Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 175
Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650
E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F
Sbjct: 176 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 224
Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693
P + A+ I R L Y+ +R+ + Q+ P++ H R+
Sbjct: 225 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 107 bits (268), Expect = 3e-23
Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)
Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
LG+G F VY A VA+K+ L K+ +KE RE I L HP I+
Sbjct: 30 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85
Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533
+LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K
Sbjct: 86 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142
Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593
+IH D+KP N+LL GE+KI DFG S ++ GT YLPPE
Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 190
Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650
E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F
Sbjct: 191 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 239
Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693
P + A+ I R L Y+ +R+ + Q+ P++ H R+
Sbjct: 240 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 107 bits (268), Expect = 3e-23
Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)
Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
LG+G F VY A VA+K+ L K+ +KE RE I L HP I+
Sbjct: 49 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104
Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 533
+LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K
Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161
Query: 534 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 593
+IH D+KP N+LL GE+KI DFG S ++ GT YLPPE
Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 209
Query: 594 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 650
E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F
Sbjct: 210 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 258
Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 693
P + A+ I R L Y+ +R+ + Q+ P++ H R+
Sbjct: 259 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 107 bits (268), Expect = 3e-23
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 29/295 (9%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHK 465
++Y +L ++G G F VYK + VA+K + K R EK+ ++ RE I +
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKEL---RNLQREIEIMR 56
Query: 466 ELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALK 525
L HP IV + D F D + V +Y EG +L L+ + E + ++I Q+V+AL
Sbjct: 57 GLRHPNIVHMLDSFETDKE-VVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114
Query: 526 YLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 585
YL+ + I+H D+KP NILL G G IK+ DFG ++ M S + M LTS G
Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAM------STNTMVLTSI-KG 162
Query: 586 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKA 645
T Y+ PE +V + P + D+WSVG I Y+ G PF I Q +++
Sbjct: 163 TPLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILK 214
Query: 646 TEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSP 700
V++P ++P K F++ L R+ L P++ H+ + P
Sbjct: 215 DPVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGP 267
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 107 bits (267), Expect = 4e-23
Identities = 93/316 (29%), Positives = 148/316 (46%), Gaps = 40/316 (12%)
Query: 412 HLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPR 471
+LLG+G F+ VY+A + VA+K+ + K + E +IH +L HP
Sbjct: 16 NLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHCQLKHPS 71
Query: 472 IVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIIMQIVNALKYLNEI 530
I++LY+YF D++ VLE C +++ YLK K SE EAR + QI+ + YL+
Sbjct: 72 ILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS- 129
Query: 531 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLS---KIMDDDSYNSVDGMELTSQGAGTY 587
I+H DL N+LL IKI DFGL+ K+ + Y GT
Sbjct: 130 -HGILHRDLTLSNLLLTRNM---NIKIADFGLATQLKMPHEKHYTL----------CGTP 175
Query: 588 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE 647
Y+ PE + + + + DVWS+G +FY L GR PF + +NT+ K
Sbjct: 176 NYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTLNKVVL 225
Query: 648 VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK------SVSTSSPA 701
+ ++ EAK I + L DR+ + + P++ + +V S +
Sbjct: 226 ADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDS 285
Query: 702 GAAIASTSGASNNSSS 717
G A ST+ +++S+S
Sbjct: 286 GHATISTAITASSSTS 301
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 106 bits (265), Expect = 7e-23
Identities = 89/281 (31%), Positives = 133/281 (47%), Gaps = 30/281 (10%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467
Y LL +G+G F++V A + R VA+KI + + + + RE RI K L
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPSSLQKLFREVRIMKGL 113
Query: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527
+HP IVKL++ + + V+EY ++ YL H M EKEAR+ QIV+A+ Y
Sbjct: 114 NHPNIVKLFEVIETEKTLYL-VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 172
Query: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587
++ I+H DLK N+LL A IKI DFG S N G+
Sbjct: 173 HQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS--------NEFTLGSKLDTFCGSP 219
Query: 588 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTILKAT 646
Y PE F K +VD+WS+GVI Y + G PF GHN + L+E +
Sbjct: 220 PYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRGKY 273
Query: 647 EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
V F ++ + ++ +RR L R ++Q+ D ++
Sbjct: 274 RVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 106 bits (264), Expect = 9e-23
Identities = 84/277 (30%), Positives = 138/277 (49%), Gaps = 25/277 (9%)
Query: 414 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 473
LGRG F+ V K + A K + + +D + E H+ A E D+P ++
Sbjct: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELA----QDNPWVI 122
Query: 474 KLYDYFSLDTDSFCTVLEYCEGNDL--DFYLKQHKLMSEKEARSIIMQIVNALKYLNEIK 531
L++ + ++ VLEY G ++ + + EK+ + ++ QI+ + +L+
Sbjct: 123 NLHEVYETASEMIL-VLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHT-- 179
Query: 532 PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLP 591
++H DLKP NILL + + G+IKI DFGLS+I+ NS + E+ GT Y+
Sbjct: 180 RDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILK----NSEELREI----MGTPEYVA 231
Query: 592 PECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI-LKATEVQF 650
PE ++ +P IS D+WS+GV+ Y L G PF N Q+ L + + L +E +F
Sbjct: 232 PE--ILSYDP--ISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEF 287
Query: 651 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
V++ A FIR L + EDR ++ P+L
Sbjct: 288 ---DVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 583
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 584 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 643
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 644 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 105 bits (261), Expect = 2e-22
Identities = 91/303 (30%), Positives = 147/303 (48%), Gaps = 38/303 (12%)
Query: 401 HPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACRE 460
H T++D + + LG+G F VY A + VA+K+ L K+ +KE RE
Sbjct: 71 HFTIDD-FEIGRPLGKGKFGNVYLAREKKSHFIVALKV--LFKS--QIEKEGVEHQLRRE 125
Query: 461 YRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 520
I L HP I++LY+YF D +LEY +L L++ E+ +I+ ++
Sbjct: 126 IEIQAHLHHPNILRLYNYF-YDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 184
Query: 521 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELT 580
+AL Y + K +IH D+KP N+LL GE+KI DFG S V L
Sbjct: 185 ADALMYCHGKK--VIHRDIKPENLLL---GLKGELKIADFGWS----------VHAPSLR 229
Query: 581 SQG-AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDI 636
+ GT YLPPE E + KVD+W +GV+ Y+ L G PF HN++ + I
Sbjct: 230 RKTMCGTLDYLPPEMI----EGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRI 285
Query: 637 LQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS 696
++ +++FP V A+ I + L + +R+ + Q++ P++ + R+ +
Sbjct: 286 VK-------VDLKFPAS--VPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLP 336
Query: 697 TSS 699
S+
Sbjct: 337 PSA 339
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 104 bits (260), Expect = 2e-22
Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + + T Q Y A I+ + RD +K RE RI
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 584
+ + I+H DLKP N+LL + + +K+ DFGL+ + D + A
Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175
Query: 585 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 644
GT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +K
Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227
Query: 645 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
A FP VTPEAK I + L RI + P++
Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 104 bits (260), Expect = 2e-22
Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%)
Query: 406 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 464
D Y L LG+G FS V + + T Q Y A I+ + RD +K RE RI
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 465 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 524
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124
Query: 525 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 584
+ + I+H DLKP N+LL + + +K+ DFGL+ + D + A
Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175
Query: 585 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 644
GT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +K
Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227
Query: 645 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
A FP VTPEAK I + L RI + P++
Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,341,287
Number of Sequences: 37866
Number of extensions: 1313075
Number of successful extensions: 8436
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 261
Number of HSP's successfully gapped in prelim test: 855
Number of HSP's that attempted gapping in prelim test: 5687
Number of HSP's gapped (non-prelim): 2106
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.