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Search of human proteins with 158508542
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|158508542 kelch-like 33 [Homo sapiens]
(453 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|158508542 kelch-like 33 [Homo sapiens] 932 0.0
gi|24308181 kelch-like 9 [Homo sapiens] 164 1e-40
gi|45643138 kelch-like 13 [Homo sapiens] 163 3e-40
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 152 6e-37
gi|31542246 kelch-like 36 [Homo sapiens] 145 6e-35
gi|55741643 kelch-like 14 [Homo sapiens] 144 2e-34
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 137 3e-32
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 137 3e-32
gi|24432026 kelch-like [Homo sapiens] 136 3e-32
gi|8922854 kelch-like 26 [Homo sapiens] 135 6e-32
gi|34101268 kelch-like 8 [Homo sapiens] 134 1e-31
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 129 5e-30
gi|38194229 kelch-like 17 [Homo sapiens] 129 5e-30
gi|40807500 kelch-like 20 [Homo sapiens] 127 3e-29
gi|14780904 kelch-like 1 protein [Homo sapiens] 125 1e-28
gi|156616301 kelch-like 32 [Homo sapiens] 124 2e-28
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 124 2e-28
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 122 9e-28
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 120 3e-27
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 120 3e-27
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 120 3e-27
gi|11056006 kelch-like 12 [Homo sapiens] 119 4e-27
gi|148664209 kelch-like 10 [Homo sapiens] 111 1e-24
gi|55925604 kelch-like 18 [Homo sapiens] 111 2e-24
gi|11545731 gigaxonin [Homo sapiens] 109 6e-24
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 107 2e-23
gi|23397572 kelch-like 34 [Homo sapiens] 106 5e-23
gi|166235129 kelch-like 3 [Homo sapiens] 103 2e-22
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 102 5e-22
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 101 1e-21
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 932 bits (2410), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 1 MAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAA 60
MAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAA
Sbjct: 1 MAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAA 60
Query: 61 RCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPG 120
RCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPG
Sbjct: 61 RCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPG 120
Query: 121 QERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPG 180
QERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPG
Sbjct: 121 QERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPG 180
Query: 181 RFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVAL 240
RFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVAL
Sbjct: 181 RFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVAL 240
Query: 241 DGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGT 300
DGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGT
Sbjct: 241 DGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGT 300
Query: 301 GQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYEL 360
GQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYEL
Sbjct: 301 GQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYEL 360
Query: 361 RTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTL 420
RTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTL
Sbjct: 361 RTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTL 420
Query: 421 PRPRAEMPACILTLPAVQHIALVPTPHQTKPAG 453
PRPRAEMPACILTLPAVQHIALVPTPHQTKPAG
Sbjct: 421 PRPRAEMPACILTLPAVQHIALVPTPHQTKPAG 453
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 164 bits (416), Expect = 1e-40
Identities = 133/439 (30%), Positives = 201/439 (45%), Gaps = 39/439 (8%)
Query: 16 HYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEA 75
+++L + PA+ F LP LA +L S+ L E E F AA WL + A
Sbjct: 175 NFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAA 234
Query: 76 KALLRCVRFGRMSTREL-RRVRAAGLLPPLTPDLLHQLMVEAD----VPGQERRREPDRA 130
K L++ +RF M+ ++L V+ + T + L++EA +P + + DR
Sbjct: 235 K-LMKNIRFPLMTPQDLINYVQTVDFMR--TDNTCVNLLLEASNYQMMPYMQPVMQSDRT 291
Query: 131 --------LVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRF 182
LV +GG LR + + + R R EW L + AP R+
Sbjct: 292 AIRSDSTHLVTLGGV-LRQQLVVSKELRMYD-----------ERAQEWRSLAPMDAP-RY 338
Query: 183 RHGAASLAGSELYVCGGQDFYSHSNTLA--STLRWEPSQEDWEEMAPLSQARSLFSLVAL 240
+HG A + G+ LYV GGQ Y A + R++P W ++A L++ R+ F L AL
Sbjct: 339 QHGIAVI-GNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 397
Query: 241 DGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGT 300
G LYA+GGR L +VE YNP +N W + P + HA + G +Y+SGG
Sbjct: 398 KGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI-TH 456
Query: 301 GQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAG-----GLGETEDLLSF 355
+ LM +DP +K +PM R H M +G +LYV G G + +D+LS
Sbjct: 457 DTFQNELMCFDPDTDK-WMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC 515
Query: 356 EAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWL 415
E Y D WT +A + AV + ++ V+GGYS + ++ Y P W
Sbjct: 516 EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWH 575
Query: 416 CLGTLPRPRAEMPACILTL 434
+ LP + AC LT+
Sbjct: 576 KVFDLPESLGGIRACTLTV 594
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 163 bits (413), Expect = 3e-40
Identities = 137/455 (30%), Positives = 208/455 (45%), Gaps = 41/455 (9%)
Query: 17 YLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAK 76
++L + PA+ F LP LA +L S+ L E E F A WL + AK
Sbjct: 218 FVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAK 277
Query: 77 ALLRCVRFGRMSTREL-RRVRAAGLLPPLTPDLLHQLMVEAD----VPGQERRREPDRA- 130
L++ +RF M+ +EL V+ + T + L++EA +P + + DR
Sbjct: 278 -LMKNIRFPLMTPQELINYVQTVDFMR--TDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 334
Query: 131 -------LVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFR 183
LV +GG LR + + + R ++ +A EW L + AP R++
Sbjct: 335 IRSDTTHLVTLGGV-LRQQLVVSKELR-MYDEKAH----------EWKSLAPMDAP-RYQ 381
Query: 184 HGAASLAGSELYVCGGQDFYSHSNTLA--STLRWEPSQEDWEEMAPLSQARSLFSLVALD 241
HG A + G+ LYV GGQ Y A + R++P W ++A L++ R+ F L AL
Sbjct: 382 HGIAVI-GNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALK 440
Query: 242 GKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTG 301
G LYA+GGR+ L +VE YNP N W + P + HA + G +Y+SGG
Sbjct: 441 GYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI-THD 499
Query: 302 QYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAG-----GLGETEDLLSFE 356
+ LM +DP +K +PM R H M +G RLYV G G + +D+LS E
Sbjct: 500 TFQKELMCFDPDTDK-WIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558
Query: 357 AYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLC 416
Y D WT +A + AV + ++ V+GGYS + ++ Y P W
Sbjct: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618
Query: 417 LGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKP 451
+ LP + AC LT+ + P+P + P
Sbjct: 619 VFDLPESLGGIRACTLTVFPPEE--TTPSPSRESP 651
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 152 bits (384), Expect = 6e-37
Identities = 134/459 (29%), Positives = 203/459 (44%), Gaps = 45/459 (9%)
Query: 1 MAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAA 60
+AE L+ + A+ ++ + A F L + ELL D+L + E AF A
Sbjct: 178 IAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIA 237
Query: 61 RCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDL-LHQLMVEA--- 116
WL + + + A LL +RFG +S ++L V +P + D H+L+V+A
Sbjct: 238 MKWLEFD-QKRVKYAADLLSNIRFGTISAQDL--VNYVQSVPRMMQDADCHRLLVDAMNY 294
Query: 117 ------DVPGQERR---REPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRT 167
Q RR R R LV +GG RP + + SR + L R
Sbjct: 295 HLLPYHQNTLQSRRTRIRGGCRVLVTVGG---RPGLTEKSLSRDI-----------LYRD 340
Query: 168 VE--WGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSN----TLASTLRWEPSQED 221
E W +L +PA F A + G LYV GG+D N +++ R++P
Sbjct: 341 PENGWSKLTEMPAKS-FNQCVAVMDGF-LYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
Query: 222 WEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFA 281
W +A ++Q R+ FSL +G +YA GGR+ + +L S+E Y P N W+P L
Sbjct: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCC 458
Query: 282 HAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLY 341
HA+A+ +G++ V+GG Y S+ YDP + L + PR H L R+Y
Sbjct: 459 HASAVADGRVLVTGGYIANA-YSRSVCAYDPASDS-WQELPNLSTPRGWHCAVTLSDRVY 516
Query: 342 VAGG-----LGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHR 396
V GG GE D+L+ E Y T W++ APL A + L G ++GG++
Sbjct: 517 VMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEG 576
Query: 397 TYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLP 435
I + P L W LP + C L++P
Sbjct: 577 EKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMP 615
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 145 bits (367), Expect = 6e-35
Identities = 130/476 (27%), Positives = 210/476 (44%), Gaps = 46/476 (9%)
Query: 1 MAEAPGLERLWSKARHYLLTHLPAVALCPAF-PSLPAACLAELLDSDELHVQEEFEAFVA 59
+A L+RL + ++L H ++ P F ++ L L S E+ + E + A
Sbjct: 154 LASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQA 213
Query: 60 ARCWLAANPETQESEAKALLRCVRFGRMSTREL-RRVRAA--GLLPP-------LTPDLL 109
A WL PE +E+ A+ +L + F + +L RV+ A LLP + +
Sbjct: 214 ALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVR 272
Query: 110 HQLMVEADVPGQERR---REPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVR 166
+ + A Q +R R L+ +GG+ + L + C + +
Sbjct: 273 YHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDT----------CYLD-AK 321
Query: 167 TVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTL--RWEPSQEDWEE 224
+ +W + P P R H ++ G +++ GG + AS L R++P + W +
Sbjct: 322 SEQW--VKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIK 379
Query: 225 MAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAA 284
+A ++Q R F L +++ L A+GGR+ + AL SVETY+P+ + W LP + HA
Sbjct: 380 VASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAG 439
Query: 285 AILEGQLYVSGGCG-GTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVA 343
I + +Y+SGG G Y +L+ YD + + PM R H M +LG +Y
Sbjct: 440 TIYKDFVYISGGHDYQIGPYRKNLLCYDHRTD-VWEERRPMTTARGWHSMCSLGDSIYSI 498
Query: 344 GGLG------ETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRT 397
GG E D+L EAY + + WT +APL + + AV +G + +LGGYS
Sbjct: 499 GGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWEN 558
Query: 398 YALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKPAG 453
A S + Y +W LP+ A AC+ AL P P K G
Sbjct: 559 TAFSKTVQVYDREADKWSRGVDLPKAIAGGSACV--------CALEPRPEDKKKKG 606
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 144 bits (363), Expect = 2e-34
Identities = 127/414 (30%), Positives = 186/414 (44%), Gaps = 39/414 (9%)
Query: 42 LLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTREL-RRVRAAGL 100
LLDS V+ E F + WL + ET+ A L++ +RF + EL RV++
Sbjct: 224 LLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDF 283
Query: 101 L--PPLTPDLLHQLMVEADVPGQE--------RRREPDRALVVIGGDGLRPDMALRQPSR 150
+ P+ LL M +P ++ R R + L+++GG PD R PS
Sbjct: 284 MRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPD---RLPSN 340
Query: 151 AVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYS----HS 206
V + + W L +P H + L+V GG+D ++ HS
Sbjct: 341 LVQYYDDEK--------KTWKILTIMPYNSA--HHCVVEVENFLFVLGGEDQWNPNGKHS 390
Query: 207 NTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPEL 266
S R++P W ++ P+ + R+ F LD LY +GGR+ L SVE YN E
Sbjct: 391 TNFVS--RYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLET 448
Query: 267 NVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGV 326
N WR +LP P AHA A+ G++Y+SGG G+Y+ L YDP ++ M
Sbjct: 449 NEWRYVSSLPQPLAAHAGAVHNGKIYISGGV-HNGEYVPWLYCYDPVMD-VWARKQDMNT 506
Query: 327 PRAGHVMAALGGRLYVAGG---LGETE-DLLSFEAYELRTDSWTHL-APLPSPHVGAASA 381
RA H +A + RLY GG G + D++ E Y+ + D W L P+ G A
Sbjct: 507 KRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCA 566
Query: 382 VLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCL-GTLPRPRAEMPACILTL 434
VL + ++GGYS A YCP G W L G + P A PAC+ +
Sbjct: 567 VLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAG-PACVTVI 619
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 137 bits (344), Expect = 3e-32
Identities = 114/422 (27%), Positives = 176/422 (41%), Gaps = 30/422 (7%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
AE G L +AR Y+ H VA F +L L L+ D+L+V+ E E F A
Sbjct: 191 AEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACI 250
Query: 62 CWLAANPETQESEAKALLRCVR-------FGRMSTRELRRVRAAGLLPPLTPDLLHQLMV 114
W+ + E + +ALLR VR F +M ++ +++ + +L +
Sbjct: 251 NWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTL 310
Query: 115 EADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLP 174
R L+ G R ++ + A+ G W +L
Sbjct: 311 HKPTQVMPCRAPKVGRLIYTAGGYFRQSLS---------YLEAYNPSDGT-----WLRLA 356
Query: 175 ALPAPGRFRHGAAS-LAGSELYVCGGQDFYSHSNTLASTLR-WEPSQEDWEEMAPLSQAR 232
L P R G A + G LY GG++ NT +S L + P W AP+S R
Sbjct: 357 DLQVP---RSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Query: 233 SLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLY 292
+ + +DG +YA+GG H + +SVE Y PE + W + A+L LY
Sbjct: 414 NRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473
Query: 293 VSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDL 352
GG GT + ++ +Y + E ++ M R+G + L +Y AGG + L
Sbjct: 474 AVGGFDGTNRLNSAECYYPERNE--WRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 353 LSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLG 412
S E Y++ T++WT +AP+ V QG + VLGGY T+ S + Y P
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDS--VECYDPDTD 589
Query: 413 RW 414
W
Sbjct: 590 TW 591
Score = 38.5 bits (88), Expect = 0.013
Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 11/113 (9%)
Query: 314 LEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPS 373
L KP T + P P+ G + +Y AGG + L EAY +W LA L
Sbjct: 310 LHKP-TQVMPCRAPKVGRL-------IYTAGGYFR-QSLSYLEAYNPSDGTWLRLADLQV 360
Query: 374 PHVGAASAVLQGELLVLGGYSHRT--YALSHLIHAYCPGLGRWLCLGTLPRPR 424
P G A V+ G L +GG ++ S + Y P +W + PR
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Score = 32.3 bits (72), Expect = 0.91
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 10/74 (13%)
Query: 359 ELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLG 418
EL T + P +P VG + GGY ++ LS+L AY P G WL L
Sbjct: 307 ELTLHKPTQVMPCRAPKVGRL-------IYTAGGYFRQS--LSYL-EAYNPSDGTWLRLA 356
Query: 419 TLPRPRAEMPACIL 432
L PR+ + C++
Sbjct: 357 DLQVPRSGLAGCVV 370
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 137 bits (344), Expect = 3e-32
Identities = 114/422 (27%), Positives = 176/422 (41%), Gaps = 30/422 (7%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
AE G L +AR Y+ H VA F +L L L+ D+L+V+ E E F A
Sbjct: 191 AEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACI 250
Query: 62 CWLAANPETQESEAKALLRCVR-------FGRMSTRELRRVRAAGLLPPLTPDLLHQLMV 114
W+ + E + +ALLR VR F +M ++ +++ + +L +
Sbjct: 251 NWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTL 310
Query: 115 EADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLP 174
R L+ G R ++ + A+ G W +L
Sbjct: 311 HKPTQVMPCRAPKVGRLIYTAGGYFRQSLS---------YLEAYNPSDGT-----WLRLA 356
Query: 175 ALPAPGRFRHGAAS-LAGSELYVCGGQDFYSHSNTLASTLR-WEPSQEDWEEMAPLSQAR 232
L P R G A + G LY GG++ NT +S L + P W AP+S R
Sbjct: 357 DLQVP---RSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Query: 233 SLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLY 292
+ + +DG +YA+GG H + +SVE Y PE + W + A+L LY
Sbjct: 414 NRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473
Query: 293 VSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDL 352
GG GT + ++ +Y + E ++ M R+G + L +Y AGG + L
Sbjct: 474 AVGGFDGTNRLNSAECYYPERNE--WRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 353 LSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLG 412
S E Y++ T++WT +AP+ V QG + VLGGY T+ S + Y P
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDS--VECYDPDTD 589
Query: 413 RW 414
W
Sbjct: 590 TW 591
Score = 38.5 bits (88), Expect = 0.013
Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 11/113 (9%)
Query: 314 LEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPS 373
L KP T + P P+ G + +Y AGG + L EAY +W LA L
Sbjct: 310 LHKP-TQVMPCRAPKVGRL-------IYTAGGYFR-QSLSYLEAYNPSDGTWLRLADLQV 360
Query: 374 PHVGAASAVLQGELLVLGGYSHRT--YALSHLIHAYCPGLGRWLCLGTLPRPR 424
P G A V+ G L +GG ++ S + Y P +W + PR
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Score = 32.3 bits (72), Expect = 0.91
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 10/74 (13%)
Query: 359 ELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLG 418
EL T + P +P VG + GGY ++ LS+L AY P G WL L
Sbjct: 307 ELTLHKPTQVMPCRAPKVGRL-------IYTAGGYFRQS--LSYL-EAYNPSDGTWLRLA 356
Query: 419 TLPRPRAEMPACIL 432
L PR+ + C++
Sbjct: 357 DLQVPRSGLAGCVV 370
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 136 bits (343), Expect = 3e-32
Identities = 131/454 (28%), Positives = 187/454 (41%), Gaps = 36/454 (7%)
Query: 1 MAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAA 60
+AE L RL + Y+L + A + + LP + LL S+ L V E E + A
Sbjct: 158 LAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGA 217
Query: 61 RCWLAANPETQES-----EAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVE 115
+ + + Q E LL VRF M L+R+ PL + LM
Sbjct: 218 LLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYH 277
Query: 116 ADVPGQERRREPDRAL-------VVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTV 168
+ Q + P L V GG P L A+ +G
Sbjct: 278 RNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQ------AKYLNPLLG----- 326
Query: 169 EWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPL 228
EW A AP G A L + +Y+ GG + + R++P W ++ L
Sbjct: 327 EWKHFTASLAPRMSNQGIAVL-NNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSL 385
Query: 229 SQARSLFSLVALDGKLYALGGR--HNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAI 286
Q + S+ + +YA+ GR HND L++VE Y+P N W L +AHA A
Sbjct: 386 QQEHADLSVCVVGRYIYAVAGRDYHND--LNAVERYDPATNSWAYVAPLKREVYAHAGAT 443
Query: 287 LEGQLYVSGGCGGTGQ-YLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGG 345
LEG++Y++ CG G+ YL YDP T L+ V RA H MA L +LYV GG
Sbjct: 444 LEGKMYIT--CGRRGEDYLKETHCYDPGSNTWHT-LADGPVRRAWHGMATLLNKLYVIGG 500
Query: 346 ----LGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALS 401
G D+ Y + W+ + PLP+ H AVL + VLGG SH + +
Sbjct: 501 SNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRT 560
Query: 402 HLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLP 435
+H Y W L + + AC+LTLP
Sbjct: 561 GYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLP 594
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 135 bits (341), Expect = 6e-32
Identities = 122/435 (28%), Positives = 190/435 (43%), Gaps = 38/435 (8%)
Query: 1 MAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAA 60
MA L L + H +A F LP L L S+ L E + F AA
Sbjct: 171 MATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAA 230
Query: 61 RCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLL-HQLMVEAD-- 117
WL +P + A +L +RF M + EL V + L + D+L Q ++EA
Sbjct: 231 VRWLQHDP-ARRPRASHVLCHIRFPLMQSSEL--VDSVQTLDIMVEDVLCRQYLLEAFNY 287
Query: 118 --VPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPA 175
+P ++ + R V R D+ PS + + V + + QLP
Sbjct: 288 QVLPFRQHEMQSPRTAV-------RSDV----PSLVTFGGTPYTDSDRSVSSKVY-QLPE 335
Query: 176 LPAPGRFR----------HGAASLAGSELYVCGGQ--DFYSHSNTLASTLRWEPSQEDWE 223
P FR H ++ + +YV GGQ + S + + R++P W
Sbjct: 336 -PGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWL 394
Query: 224 EMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHA 283
+ + ++R F L L G +YA GGR+ +L SVE Y P N W A +L + HA
Sbjct: 395 RLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHA 454
Query: 284 AAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVA 343
A G+LY+SGG G + + +L YDP ++ F +PM PR H M GGR+Y
Sbjct: 455 GAASGGRLYISGGYGISVEDKKALHCYDPVADQ-WEFKAPMSEPRVLHAMVGAGGRIYAL 513
Query: 344 GG----LGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYA 399
GG + D+L+ E Y TD WT ++P+ + A +L+ ++ ++GGY+ R
Sbjct: 514 GGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNN 573
Query: 400 LSHLIHAYCPGLGRW 414
++ ++ Y W
Sbjct: 574 VTGIVQVYNTDTDEW 588
Score = 86.7 bits (213), Expect = 4e-17
Identities = 68/249 (27%), Positives = 105/249 (42%), Gaps = 12/249 (4%)
Query: 194 LYVCGGQDFYSHSNTLASTLRW--EPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRH 251
L GG + +++S + EP + E+ + S + LD +Y GG+H
Sbjct: 311 LVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQH 370
Query: 252 -----NDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLAS 306
+ A+D+ Y+P LN W A+ +L G +Y +GG G LAS
Sbjct: 371 LQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGS-LAS 429
Query: 307 LMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLG-ETEDLLSFEAYELRTDSW 365
+ Y P+ + G + + GH AA GGRLY++GG G ED + Y+ D W
Sbjct: 430 VERYCPRRNEWG-YACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQW 488
Query: 366 THLAPLPSPHVGAASAVLQGELLVLGG-YSHRTYALSHL-IHAYCPGLGRWLCLGTLPRP 423
AP+ P V A G + LGG H L + Y P +W + +
Sbjct: 489 EFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAG 548
Query: 424 RAEMPACIL 432
++E C+L
Sbjct: 549 QSEAGCCLL 557
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 134 bits (338), Expect = 1e-31
Identities = 121/439 (27%), Positives = 185/439 (42%), Gaps = 37/439 (8%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
AE+ L A Y H V C F S+ L +LL S +L+++ E + + AA
Sbjct: 176 AESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAI 235
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLT---PDLL------HQL 112
WL ANP+ L VR + L V A + DLL H
Sbjct: 236 KWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLH 295
Query: 113 MVEADVPGQER------RREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVR 166
+ VP E R+ L +GG G D P R++ C +
Sbjct: 296 LSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGD-----PFRSI------ECYS--IN 342
Query: 167 TVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMA 226
W P + + R RH ++Y GG D H L S ++P W A
Sbjct: 343 KNSWFFGPEMNS--RRRHVGVISVEGKVYAVGGHDGNEH---LGSMEMFDPLTNKWMMKA 397
Query: 227 PLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAI 286
++ R +L +L G +YA+GG ++ + VE Y+ E + W + P +
Sbjct: 398 SMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVA 457
Query: 287 LEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGL 346
L +Y GG G L+S+ YDP L+K + MG RAG+ ++ L G LYV GG
Sbjct: 458 LVNHVYAVGGNDGMAS-LSSVERYDPHLDK-WIEVKEMGQRRAGNGVSKLHGCLYVVGGF 515
Query: 347 GETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHA 406
+ L S E Y+ R++ W ++A L +P G A + G++ +GG++ Y + + A
Sbjct: 516 DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYL--NTVEA 573
Query: 407 YCPGLGRWLCLGTLPRPRA 425
+ P L RW +G++ RA
Sbjct: 574 FDPVLNRWELVGSVSHCRA 592
Score = 80.1 bits (196), Expect = 4e-15
Identities = 55/197 (27%), Positives = 91/197 (46%), Gaps = 5/197 (2%)
Query: 186 AASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLY 245
A + G +Y GG D + N + R++ + W +AP++ R VAL +Y
Sbjct: 407 ALASLGGPIYAIGGLDDNTCFNDVE---RYDIESDQWSTVAPMNTPRGGVGSVALVNHVY 463
Query: 246 ALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLA 305
A+GG +L SVE Y+P L+ W + + + L G LYV GG L+
Sbjct: 464 AVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSP-LS 522
Query: 306 SLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSW 365
S+ YDP+ K +++ + PR G +A + G+++ GG L + EA++ + W
Sbjct: 523 SVERYDPRSNK-WDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRW 581
Query: 366 THLAPLPSPHVGAASAV 382
+ + GA AV
Sbjct: 582 ELVGSVSHCRAGAGVAV 598
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 129 bits (324), Expect = 5e-30
Identities = 115/434 (26%), Positives = 178/434 (41%), Gaps = 43/434 (9%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
AE G L+ A Y+ + AV F L A L E++ +D L+V E F A
Sbjct: 144 AETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALE 203
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPP--------LTPDLLHQLM 113
W+ + + ++ LL VR +S + L R+ A L L L + M
Sbjct: 204 SWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFM 263
Query: 114 VEADVPGQE----RRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVE 169
E + Q R R + L +GG ++ +A + +
Sbjct: 264 PEHRLSHQTVLMTRPRCAPKVLCAVGG-------------KSGLFACLDSVEMYFPQNDS 310
Query: 170 WGQLPALPAPGRFRHGAASLAGSELYVCGG--------QDFYSHSNTLASTLRWEPSQED 221
W L L P R+ G L ++YV GG H N++ W P
Sbjct: 311 WIGLAPLNIP-RYEFGICVL-DQKVYVIGGIATNVRPGVTIRKHENSVEC---WNPDTNT 365
Query: 222 WEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFA 281
W + ++++RS +V L G+LYALGG L SVE Y P++ W+P +
Sbjct: 366 WTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSC 425
Query: 282 HAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLY 341
AAA+L+G +Y GG G ++ S+ YDP + ++ M R + + G ++
Sbjct: 426 FAAAVLDGMIYAIGGYGPA--HMNSVERYDPSKDS-WEMVASMADKRIHFGVGVMLGFIF 482
Query: 342 VAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALS 401
V GG L S E Y+ + WT P+ P G +AV+ L V+GG+S +Y
Sbjct: 483 VVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL-- 540
Query: 402 HLIHAYCPGLGRWL 415
+ + Y P WL
Sbjct: 541 NTVQKYDPISDTWL 554
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/234 (29%), Positives = 105/234 (44%), Gaps = 17/234 (7%)
Query: 209 LASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVA--------LDSVE 260
L S + P + W +APL+ R F + LD K+Y +GG +V +SVE
Sbjct: 298 LDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVE 357
Query: 261 TYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTF 320
+NP+ N W + +L G+LY GG G YL S+ Y PK+ K
Sbjct: 358 CWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQ-SYLQSVEKYIPKIRK-WQP 415
Query: 321 LSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAAS 380
++PM R+ A L G +Y GG G + S E Y+ DSW +A + +
Sbjct: 416 VAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRIHFGV 474
Query: 381 AVLQGELLVLGGYSHRTYALSHL--IHAYCPGLGRWLCLGTLPRPRAEMPACIL 432
V+ G + V+GG++ +SHL I Y P +W + PR + A ++
Sbjct: 475 GVMLGFIFVVGGHN----GVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVI 524
Score = 30.0 bits (66), Expect = 4.5
Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 187 ASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVAL 240
A++ + LYV GG S+ NT+ +++P + W + A + R F L AL
Sbjct: 521 AAVIDNYLYVVGGHSGSSYLNTVQ---KYDPISDTWLDSAGMIYCRCNFGLTAL 571
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 129 bits (324), Expect = 5e-30
Identities = 130/431 (30%), Positives = 178/431 (41%), Gaps = 56/431 (12%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
A+A L A Y+L H VA F LP + EL+ SD L+V E E + A
Sbjct: 201 ADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVL 260
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTR-ELRRVRAAGLL--PPLTPDLL------HQL 112
W+ + + + L++CVR +S L V A L+ P DLL H L
Sbjct: 261 SWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL 320
Query: 113 MVEADVPGQERRREPDR------ALVVIGGDGL---RPDMALRQPSRAVWW------ARA 157
+ V G R R P R L +GG L D W R
Sbjct: 321 PEQRGVLGTSRTR-PRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRR 379
Query: 158 FRCGVGLV----------------RTVE--------WGQLPALPAPGRFRHGAASLAGSE 193
R GV V TVE W Q R G A+L G
Sbjct: 380 ARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW-QPEVSMGTRRSCLGVAALHGL- 437
Query: 194 LYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHND 253
LY GG Y ++ L S R++P W +A +S R + LDG LYA+GG +
Sbjct: 438 LYSAGG---YDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSS 494
Query: 254 VALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPK 313
L +VE Y P++NVW P ++ + + A+LEG LYV+GG GT L S+ Y PK
Sbjct: 495 SHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGT-SCLNSVERYSPK 553
Query: 314 LEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPS 373
++PM + R+ H + A+ G LY GG + L S E Y RT+ W + + +
Sbjct: 554 -AGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFT 612
Query: 374 PHVGAASAVLQ 384
AVL+
Sbjct: 613 RRSSVGVAVLE 623
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 127 bits (318), Expect = 3e-29
Identities = 116/404 (28%), Positives = 183/404 (45%), Gaps = 40/404 (9%)
Query: 31 FPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTR 90
F LPA L +++ SDEL+V+ E + F A W+ + + + + +L+ VR +S +
Sbjct: 206 FMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPK 265
Query: 91 ELRRVRAAGLLPPLTPDL-LHQLMVEAD---VPGQERRREPDRALVVIGGDGLRPDMALR 146
L V G P + D L+ EA + QER ++ G RP R
Sbjct: 266 FL--VGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERP--------LMQGPRTRP----R 311
Query: 147 QPSRA--VWWARAFRCGVGLVRTVE--------WGQLPALPAPGRFRHGAA-SLAGSELY 195
+P R V +A C + +VE W + ++ + R G S+ LY
Sbjct: 312 KPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASM---SKRRCGVGVSVLDDLLY 368
Query: 196 VCGGQDFYSHSNTLASTLRWEPSQEDWE-EMAPLSQARSLFSLVALDGKLYALGGRHNDV 254
GG D S+ N++ R++P W ++AP S R+ + L G LYA+GG+
Sbjct: 369 AVGGHDGSSYLNSVE---RYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVS 425
Query: 255 ALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKL 314
L+ VE Y+P+ N W ++ A A+L G LY GG GT L ++ Y+P+
Sbjct: 426 CLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP-LNTVERYNPQE 484
Query: 315 EKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSP 374
+ T ++PMG R A +Y GG +T +L S E Y RT+ W+ + + S
Sbjct: 485 NRWHT-IAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSR 543
Query: 375 HVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLG 418
G AV+ G+L+ +GG+ TY + I + P W G
Sbjct: 544 RSGVGLAVVNGQLMAVGGFDGTTYLKT--IEVFDPDANTWRLYG 585
Score = 89.4 bits (220), Expect = 6e-18
Identities = 59/188 (31%), Positives = 91/188 (48%), Gaps = 3/188 (1%)
Query: 244 LYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQY 303
L+A+GG + A+ SVE Y+P+ N WR ++ ++L+ LY GG G+ Y
Sbjct: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSS-Y 378
Query: 304 LASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTD 363
L S+ YDPK + + ++P R +A LGG LY GG L E Y+ + +
Sbjct: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKEN 438
Query: 364 SWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRP 423
WT +A + + +G A AVL G L +GG S T L + + Y P RW + +
Sbjct: 439 KWTRVASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPL-NTVERYNPQENRWHTIAPMGTR 496
Query: 424 RAEMPACI 431
R + +
Sbjct: 497 RKHLGCAV 504
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 125 bits (313), Expect = 1e-28
Identities = 114/433 (26%), Positives = 183/433 (42%), Gaps = 57/433 (13%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
A+A G L A Y + ++ V F LPA L +LL SD+++V +E F A
Sbjct: 321 ADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALM 380
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPP-------LTPDLLHQLMV 114
W+ + +++ ++ LL +R + + L + L + + + L+
Sbjct: 381 MWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLP 440
Query: 115 EADVPGQERRREPDRALV----VIGG-DGLRPDMALRQPS-RAVWWARAF---------- 158
E Q R +P ++ V +GG D + + + R W +A
Sbjct: 441 ERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFG 500
Query: 159 -------------RCGVGLVRTVE--------WGQLPALPAPGRFRHG-AASLAGSELYV 196
R G+ + TVE W LP + RHG ++ +Y
Sbjct: 501 VAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMST---HRHGLGVTVLEGPIYA 557
Query: 197 CGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVAL 256
GG D +S+ NT+ RW+P + W +A +S ARS + AL+GKLY++GGR L
Sbjct: 558 VGGHDGWSYLNTVE---RWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCL 614
Query: 257 DSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGG-----CGGTGQYLASLMHYD 311
S+E Y+P N W + A +G LY GG + L + YD
Sbjct: 615 SSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYD 674
Query: 312 PKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPL 371
PK + T ++P+ +PR + LG RLY GG L + E+Y+ +T+ WT +A L
Sbjct: 675 PKTD-TWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL 733
Query: 372 PSPHVGAASAVLQ 384
GA V++
Sbjct: 734 NIGRAGACVVVIK 746
Score = 79.7 bits (195), Expect = 5e-15
Identities = 62/242 (25%), Positives = 93/242 (38%), Gaps = 53/242 (21%)
Query: 242 GKLYALGGRHND-----------------------------------------------V 254
G LYA+GG N+
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
Query: 255 ALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKL 314
L++VE YNP+ W P + +LEG +Y GG G YL ++ +DP+
Sbjct: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDG-WSYLNTVERWDPQS 577
Query: 315 EKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSP 374
++ TF++ M + R+ +AAL G+LY GG + L S E Y+ T+ W AP+
Sbjct: 578 QQ-WTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKR 636
Query: 375 HVGAASAVLQGELLVLGGY----SHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPAC 430
G A G L +GG+ S+ L + Y P W + L PR + C
Sbjct: 637 RGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVC 696
Query: 431 IL 432
+L
Sbjct: 697 LL 698
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 124 bits (311), Expect = 2e-28
Identities = 127/441 (28%), Positives = 188/441 (42%), Gaps = 36/441 (8%)
Query: 33 SLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTREL 92
+LP L E+L SD L E + + A WL N Q + LL+ +RFG M L
Sbjct: 184 TLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDE--LLQYIRFGLMDVDTL 241
Query: 93 RRV-------RAAGLLPPLTPDLL--HQLMVEADVPGQERRREP---DRALVVIGGDGLR 140
V +A+ L + L HQ + A Q RR +P L +IGG
Sbjct: 242 HTVALSHPLVQASETATALVNEALEYHQ-SIYAQPVWQTRRTKPRFQSDTLYIIGGK--- 297
Query: 141 PDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQ 200
+ + ++ + + W +L +P GR H A + G L+V GG+
Sbjct: 298 -KREVCKVKELRYFNPVDQENALIAAIANWSELAPMPV-GRSHHCVAVM-GDFLFVAGGE 354
Query: 201 DFYSHSNTLA--STLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHN-DVALD 257
++ T A + R++P W E+AP+ R F L A++ LYA+GGR+ L
Sbjct: 355 VEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLP 414
Query: 258 SVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKP 317
+VE Y P+ N W + HA + +G L++SGG T QY LM Y+P K
Sbjct: 415 TVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNK- 473
Query: 318 GTFLSPMGVPRAGHVMAALGGRLYVAGG--LGETEDLL---SFEAYELRTDSWTHL-APL 371
SPM R H MAA+ +LYV GG L D + ++Y + TD WT L
Sbjct: 474 WISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNL 533
Query: 372 PSPHVGAASAVLQGELLVLGGYS---HRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMP 428
+ + AV G + ++GGYS + A ++ G TLP +
Sbjct: 534 LTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIA 593
Query: 429 ACILTLP--AVQHIALVPTPH 447
AC L P ++ + PH
Sbjct: 594 ACFLPAPYFTCPNLQTLQVPH 614
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 124 bits (310), Expect = 2e-28
Identities = 116/434 (26%), Positives = 183/434 (42%), Gaps = 61/434 (14%)
Query: 3 EAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARC 62
+A G L + A Y + H V F LPA +++LL SD+++V +E F A
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 63 WLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDL-LHQLMVEA----- 116
W+ + + ++ E LL +R + + L + + + T DL +L++EA
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSM---FTGDLECQKLLMEAMKYHL 408
Query: 117 --------DVPGQERRREPDRALVVIGG-DGLRPDMAL-RQPSRAVWW-------ARAFR 159
P + R+ AL +GG D ++ + + R W R +
Sbjct: 409 LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQ 468
Query: 160 CGVGLV----------------RTVE--------WGQLPALPAPGRFRHGAASLAGSELY 195
GV ++ TVE W +P + + R G A+L G +Y
Sbjct: 469 FGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM-STHRHGLGVATLEG-PMY 526
Query: 196 VCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVA 255
GG D +S+ NT+ RW+P W +A +S RS +VAL+ KLYA+GGR
Sbjct: 527 AVGGHDGWSYLNTVE---RWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
Query: 256 LDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLM-----HY 310
L S+E ++P N W + A G LYV GG S + Y
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
Query: 311 DPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAP 370
DPK + T ++P+ VPR + LG +LYV GG L + E+Y+ + + W P
Sbjct: 644 DPKGDSWST-VAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVP 702
Query: 371 LPSPHVGAASAVLQ 384
+ GA V++
Sbjct: 703 VNIGRAGACVVVVK 716
Score = 47.0 bits (110), Expect = 4e-05
Identities = 28/89 (31%), Positives = 40/89 (44%), Gaps = 5/89 (5%)
Query: 304 LASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTD 363
L M Y E+ SP PR V G LY GG+ + + E Y+LRT+
Sbjct: 400 LMEAMKYHLLPERRSMMQSPRTKPRKSTV-----GALYAVGGMDAMKGTTTIEKYDLRTN 454
Query: 364 SWTHLAPLPSPHVGAASAVLQGELLVLGG 392
SW H+ + + AV+ +L V+GG
Sbjct: 455 SWLHIGTMNGRRLQFGVAVIDNKLYVVGG 483
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 122 bits (305), Expect = 9e-28
Identities = 111/419 (26%), Positives = 179/419 (42%), Gaps = 50/419 (11%)
Query: 3 EAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARC 62
+A G L + A Y + H V F LPA +++LL SD+++V +E F A
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 63 WLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDL-LHQLMVEA----- 116
W+ + + ++ E LL +R + + L + + + T DL +L++EA
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSM---FTGDLECQKLLMEAMKYHL 408
Query: 117 --------DVPGQERRREPDRALVVIGG-DGLRPDMALRQPSRAVWWARAFRCGVGLVRT 167
P + R+ AL +GG D ++ + + +RT
Sbjct: 409 LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYD---------------LRT 453
Query: 168 VEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAP 227
W + + GR ++ ++LYV GG+D NT+ + P + W M P
Sbjct: 454 NSWLHIGTM--NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVEC---FNPVGKIWTVMPP 508
Query: 228 LSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAIL 287
+S R + L+G +YA+GG L++VE ++PE W ++ P L
Sbjct: 509 MSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Query: 288 EGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGG-- 345
+LY GG G+ L S+ ++DP K + +PM R G +A G LYV GG
Sbjct: 569 NNKLYAIGGRDGS-SCLKSMEYFDPHTNK-WSLCAPMSKRRGGVGVATYNGFLYVVGGHD 626
Query: 346 ------LGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTY 398
D + E Y+ + DSW+ +APL P A L +L V+GGY TY
Sbjct: 627 APASNHCSRLSDCV--ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY 683
Score = 55.8 bits (133), Expect = 8e-08
Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 5/101 (4%)
Query: 175 ALPAPGRFRHGAASLA--GSELYVCGGQDF--YSHSNTLASTL-RWEPSQEDWEEMAPLS 229
+L AP R G +A LYV GG D +H + L+ + R++P + W +APLS
Sbjct: 598 SLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLS 657
Query: 230 QARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWR 270
R ++ L KLY +GG L++VE+Y+ + N W+
Sbjct: 658 VPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 120 bits (300), Expect = 3e-27
Identities = 104/435 (23%), Positives = 173/435 (39%), Gaps = 61/435 (14%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
A+A G L A +Y + H V F LPA+ +A+LL SD++++ E A
Sbjct: 283 ADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALL 342
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQ 121
W+ + E + + LL +R ++ P D+ + ++ D+ Q
Sbjct: 343 TWVRHDLEQRRKDLSKLLAYIRLPLLA-------------PQFLADMENNVLFRDDIECQ 389
Query: 122 ERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGR 181
+ E + ++ P R P L +P
Sbjct: 390 KLIMEAMKYHLL--------------PERR----------------------PMLQSP-- 411
Query: 182 FRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALD 241
R L+ GG D + ++ +++ W +A ++ R F + LD
Sbjct: 412 -RTKPRKSTVGTLFAVGGMDSTKGATSIE---KYDLRTNMWTPVANMNGRRLQFGVAVLD 467
Query: 242 GKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTG 301
KLY +GGR L++VE YNP+ W P + A+LEG +Y GG G
Sbjct: 468 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG-W 526
Query: 302 QYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELR 361
YL ++ +DP+ + F++ M PR+ +A L G+LY GG + L S E ++
Sbjct: 527 SYLNTVERWDPQ-ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH 585
Query: 362 TDSWTHLAPLPSPHVGAASAVLQGELLVLGGY----SHRTYALSHLIHAYCPGLGRWLCL 417
T+ WT A + G G L +GG+ S+ T LS + Y P W +
Sbjct: 586 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 645
Query: 418 GTLPRPRAEMPACIL 432
++ R + C+L
Sbjct: 646 ASMSISRDAVGVCLL 660
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 10/97 (10%)
Query: 194 LYVCGGQDFYSHSNTLASTL-----RWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALG 248
LY GG D + ++ L S L R++P + W +A +S +R + L KLYA+G
Sbjct: 611 LYAIGGHD--APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 668
Query: 249 GRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAA 285
G L++VE Y+P+ N W L C A A
Sbjct: 669 GYDGQAYLNTVEAYDPQTNEWTQVAPL---CLGRAGA 702
Score = 45.8 bits (107), Expect = 8e-05
Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 7/128 (5%)
Query: 308 MHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTH 367
M Y E+ SP PR V G L+ GG+ T+ S E Y+LRT+ WT
Sbjct: 396 MKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGGMDSTKGATSIEKYDLRTNMWTP 450
Query: 368 LAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEM 427
+A + + AVL +L V+GG + + Y P W + + R +
Sbjct: 451 VANMNGRRLQFGVAVLDDKLYVVGG--RDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGL 508
Query: 428 PACILTLP 435
+L P
Sbjct: 509 GVAVLEGP 516
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 120 bits (300), Expect = 3e-27
Identities = 104/435 (23%), Positives = 173/435 (39%), Gaps = 61/435 (14%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
A+A G L A +Y + H V F LPA+ +A+LL SD++++ E A
Sbjct: 268 ADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALL 327
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQ 121
W+ + E + + LL +R ++ P D+ + ++ D+ Q
Sbjct: 328 TWVRHDLEQRRKDLSKLLAYIRLPLLA-------------PQFLADMENNVLFRDDIECQ 374
Query: 122 ERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGR 181
+ E + ++ P R P L +P
Sbjct: 375 KLIMEAMKYHLL--------------PERR----------------------PMLQSP-- 396
Query: 182 FRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALD 241
R L+ GG D + ++ +++ W +A ++ R F + LD
Sbjct: 397 -RTKPRKSTVGTLFAVGGMDSTKGATSIE---KYDLRTNMWTPVANMNGRRLQFGVAVLD 452
Query: 242 GKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTG 301
KLY +GGR L++VE YNP+ W P + A+LEG +Y GG G
Sbjct: 453 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG-W 511
Query: 302 QYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELR 361
YL ++ +DP+ + F++ M PR+ +A L G+LY GG + L S E ++
Sbjct: 512 SYLNTVERWDPQ-ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH 570
Query: 362 TDSWTHLAPLPSPHVGAASAVLQGELLVLGGY----SHRTYALSHLIHAYCPGLGRWLCL 417
T+ WT A + G G L +GG+ S+ T LS + Y P W +
Sbjct: 571 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 630
Query: 418 GTLPRPRAEMPACIL 432
++ R + C+L
Sbjct: 631 ASMSISRDAVGVCLL 645
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 10/97 (10%)
Query: 194 LYVCGGQDFYSHSNTLASTL-----RWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALG 248
LY GG D + ++ L S L R++P + W +A +S +R + L KLYA+G
Sbjct: 596 LYAIGGHD--APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
Query: 249 GRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAA 285
G L++VE Y+P+ N W L C A A
Sbjct: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPL---CLGRAGA 687
Score = 45.8 bits (107), Expect = 8e-05
Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 7/128 (5%)
Query: 308 MHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTH 367
M Y E+ SP PR V G L+ GG+ T+ S E Y+LRT+ WT
Sbjct: 381 MKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGGMDSTKGATSIEKYDLRTNMWTP 435
Query: 368 LAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEM 427
+A + + AVL +L V+GG + + Y P W + + R +
Sbjct: 436 VANMNGRRLQFGVAVLDDKLYVVGG--RDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGL 493
Query: 428 PACILTLP 435
+L P
Sbjct: 494 GVAVLEGP 501
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 120 bits (300), Expect = 3e-27
Identities = 104/435 (23%), Positives = 173/435 (39%), Gaps = 61/435 (14%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
A+A G L A +Y + H V F LPA+ +A+LL SD++++ E A
Sbjct: 329 ADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALL 388
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQ 121
W+ + E + + LL +R ++ P D+ + ++ D+ Q
Sbjct: 389 TWVRHDLEQRRKDLSKLLAYIRLPLLA-------------PQFLADMENNVLFRDDIECQ 435
Query: 122 ERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGR 181
+ E + ++ P R P L +P
Sbjct: 436 KLIMEAMKYHLL--------------PERR----------------------PMLQSP-- 457
Query: 182 FRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALD 241
R L+ GG D + ++ +++ W +A ++ R F + LD
Sbjct: 458 -RTKPRKSTVGTLFAVGGMDSTKGATSIE---KYDLRTNMWTPVANMNGRRLQFGVAVLD 513
Query: 242 GKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTG 301
KLY +GGR L++VE YNP+ W P + A+LEG +Y GG G
Sbjct: 514 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG-W 572
Query: 302 QYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELR 361
YL ++ +DP+ + F++ M PR+ +A L G+LY GG + L S E ++
Sbjct: 573 SYLNTVERWDPQ-ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH 631
Query: 362 TDSWTHLAPLPSPHVGAASAVLQGELLVLGGY----SHRTYALSHLIHAYCPGLGRWLCL 417
T+ WT A + G G L +GG+ S+ T LS + Y P W +
Sbjct: 632 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 691
Query: 418 GTLPRPRAEMPACIL 432
++ R + C+L
Sbjct: 692 ASMSISRDAVGVCLL 706
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 10/97 (10%)
Query: 194 LYVCGGQDFYSHSNTLASTL-----RWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALG 248
LY GG D + ++ L S L R++P + W +A +S +R + L KLYA+G
Sbjct: 657 LYAIGGHD--APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 714
Query: 249 GRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAA 285
G L++VE Y+P+ N W L C A A
Sbjct: 715 GYDGQAYLNTVEAYDPQTNEWTQVAPL---CLGRAGA 748
Score = 45.8 bits (107), Expect = 8e-05
Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 7/128 (5%)
Query: 308 MHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTH 367
M Y E+ SP PR V G L+ GG+ T+ S E Y+LRT+ WT
Sbjct: 442 MKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGGMDSTKGATSIEKYDLRTNMWTP 496
Query: 368 LAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEM 427
+A + + AVL +L V+GG + + Y P W + + R +
Sbjct: 497 VANMNGRRLQFGVAVLDDKLYVVGG--RDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGL 554
Query: 428 PACILTLP 435
+L P
Sbjct: 555 GVAVLEGP 562
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 119 bits (299), Expect = 4e-27
Identities = 112/443 (25%), Positives = 174/443 (39%), Gaps = 31/443 (6%)
Query: 2 AEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAAR 61
AE L A + H P V F L + +L+ DE+ V E F A
Sbjct: 142 AETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVI 201
Query: 62 CWLAANPETQESEAKALLRCVRFGRMSTRELRRV-------RAAGLLPPLTPD-----LL 109
W+ + +E LL+ VR ++ R + V R + L + L
Sbjct: 202 NWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLR 261
Query: 110 HQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVE 169
+L + P R + L+V+GG G + + P V +T E
Sbjct: 262 PELRSQMQGPRTRARLGANEVLLVVGGFG-----SQQSPIDVVEKYDP--------KTQE 308
Query: 170 WGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLS 229
W LP++ + R+ A+ +YV GG D S +++ W +AP++
Sbjct: 309 WSFLPSITR--KRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMN 366
Query: 230 QARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEG 289
R L L +Y GG S+E Y+P ++ W + + G
Sbjct: 367 VRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASG 426
Query: 290 QLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGET 349
+Y GG G L S+ YDP T ++PM R+G +A L +YV GG T
Sbjct: 427 VIYCLGGYDGL-NILNSVEKYDPHTGH-WTNVTPMATKRSGAGVALLNDHIYVVGGFDGT 484
Query: 350 EDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCP 409
L S EAY +RTDSWT + + +P + VL+G L + GY + S I Y P
Sbjct: 485 AHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSS--IECYDP 542
Query: 410 GLGRWLCLGTLPRPRAEMPACIL 432
+ W + ++ R + C+L
Sbjct: 543 IIDSWEVVTSMGTQRCDAGVCVL 565
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 111 bits (278), Expect = 1e-24
Identities = 107/425 (25%), Positives = 177/425 (41%), Gaps = 41/425 (9%)
Query: 25 VALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRF 84
V + F L L ++++ DEL+V++E F A W++ +P+ ++ LL VR
Sbjct: 172 VKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRL 231
Query: 85 GRMSTRELRR-------VRAAGLLPPLTPDLLHQLMVEADVPGQE---------RRREPD 128
M V+ + P+ + L + M + ++ G R R P
Sbjct: 232 ALMHAEYFMNNVKMNDYVKDSEECKPVIINAL-KAMYDLNMNGPSNSDFTNPLTRPRLPY 290
Query: 129 RALVVIGG-DGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAA 187
L IGG G P A+ + ARA R W + R HGAA
Sbjct: 291 AILFAIGGWSGGSPTNAIE-----AYDARADR----------WVNVTCEEESPRAYHGAA 335
Query: 188 SLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYAL 247
L G +Y+ GG D + N S R++P ++ W ++AP+ R S+ L +YA+
Sbjct: 336 YLKG-YVYIIGGFDSVDYFN---SVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAM 391
Query: 248 GGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASL 307
GG V L++ E Y PE N W + +A L G++Y+ GG G + L +
Sbjct: 392 GGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG-NECLFTA 450
Query: 308 MHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTH 367
Y+ + T ++PM R+G + A G +Y GG L S EAY ++W
Sbjct: 451 EVYNTE-SNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRT 509
Query: 368 LAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEM 427
+ + +P V+ L V+GG++ T + + Y W + R+ +
Sbjct: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFN--VECYDEKTDEWYDAHDMSIYRSAL 567
Query: 428 PACIL 432
C++
Sbjct: 568 SCCVV 572
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 111 bits (277), Expect = 2e-24
Identities = 102/385 (26%), Positives = 161/385 (41%), Gaps = 55/385 (14%)
Query: 10 LWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPE 69
L+ A ++ H V++ F +LP + EL+ DEL+V+ E + F AA W+ + E
Sbjct: 155 LYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDRE 214
Query: 70 TQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQERRREPDR 129
+ LL +R LP P L + + D+ R R
Sbjct: 215 QRGPYLPELLSNIR-----------------LPLCRPQFLSDRVQQDDLV---RCCHKCR 254
Query: 130 ALVVIGGD-GLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAAS 188
LV D L P+ + P LPA S
Sbjct: 255 DLVDEAKDYHLMPE-----------------------------RRPHLPAFRTRPRCCTS 285
Query: 189 LAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALG 248
+AG +Y GG + S ++L ++P WE P++ ARS + ++G LYA+G
Sbjct: 286 IAGL-IYAVGGLN--SAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIG 342
Query: 249 GRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLM 308
G + L +VE YNPE + W ++ + A +L+GQ+YV GG G L+S+
Sbjct: 343 GYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSS-LSSVE 401
Query: 309 HYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHL 368
Y P+ +K T ++ M R+ + GR+YV+GG + S E Y T +W
Sbjct: 402 TYSPETDK-WTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPA 460
Query: 369 APLPSPHVGAASAVLQGELLVLGGY 393
A + + +A L ++ V GGY
Sbjct: 461 AGMLNKRCRHGAASLGSKMFVCGGY 485
Score = 95.1 bits (235), Expect = 1e-19
Identities = 55/179 (30%), Positives = 83/179 (46%), Gaps = 5/179 (2%)
Query: 193 ELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHN 252
++YVCGG Y +++L+S + P + W + +S RS + +G++Y GG
Sbjct: 384 QIYVCGG---YDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDG 440
Query: 253 DVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDP 312
SVE YN W PA + H AA L +++V GG G+G S+
Sbjct: 441 LQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSG--FLSIAEMYS 498
Query: 313 KLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPL 371
+ + PM R+ + A GRLY GG +L S E Y+ TD WT +AP+
Sbjct: 499 SVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 109 bits (272), Expect = 6e-24
Identities = 98/360 (27%), Positives = 158/360 (43%), Gaps = 29/360 (8%)
Query: 14 ARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQES 73
A YL TH V+ F L L E++ ++L+V E F A W+A + E ++
Sbjct: 153 ATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDTEIRKV 212
Query: 74 EAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLM-VEADVPGQE-------RRR 125
K ++ + + + LR L PL +++ + + P Q + R
Sbjct: 213 HMKDVMSALWVSGLDSSYLREQM---LNEPLVREIVKECSNIPLSQPQQGEAMLANFKPR 269
Query: 126 EPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVE--WGQLPALPAPGRFR 183
+V +GG+ + R+P+ A+ RC L W +L L P R
Sbjct: 270 GYSECIVTVGGE----ERVSRKPTAAM------RCMCPLYDPNRQLWIELAPLSMP-RIN 318
Query: 184 HGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGK 243
HG S G L+V GGQD + TL+S +++P W + P+++AR F +V +DG
Sbjct: 319 HGVLSAEGF-LFVFGGQD--ENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGM 375
Query: 244 LYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQY 303
LY LGG + L S+E Y+ W P L A ++ ++Y GG G G+
Sbjct: 376 LYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGG-GSYGKL 434
Query: 304 LASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTD 363
S+ YDP+ ++ T + P+ R G V + LYV GG+ ED E +++
Sbjct: 435 FESVECYDPRTQQ-WTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTCKSE 493
Score = 84.3 bits (207), Expect = 2e-16
Identities = 61/203 (30%), Positives = 93/203 (45%), Gaps = 6/203 (2%)
Query: 198 GGQDFYSHSNTLASTLR---WEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGR-HND 253
GG++ S T A ++P+++ W E+APLS R +++ +G L+ GG+ N
Sbjct: 279 GGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENK 338
Query: 254 VALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPK 313
L S E Y+P+ N W P + ++G LY+ GG G + L S+ YD
Sbjct: 339 QTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKE-LISMECYDI- 396
Query: 314 LEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPS 373
K T + + R AA+ ++Y GG + S E Y+ RT WT + PL
Sbjct: 397 YSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKE 456
Query: 374 PHVGAASAVLQGELLVLGGYSHR 396
GA + + EL V GG R
Sbjct: 457 RRFGAVACGVAMELYVFGGVRSR 479
Score = 67.0 bits (162), Expect = 3e-11
Identities = 47/169 (27%), Positives = 70/169 (41%), Gaps = 3/169 (1%)
Query: 262 YNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFL 321
Y+P +W L P H EG L+V GG Q L+S YDP T L
Sbjct: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANT-WTAL 357
Query: 322 SPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASA 381
PM R + + G LY+ GG ++L+S E Y++ + +WT L A
Sbjct: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA 417
Query: 382 VLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPAC 430
++ ++ +GG S+ L + Y P +W + L R AC
Sbjct: 418 AMKKKIYAMGGGSYG--KLFESVECYDPRTQQWTAICPLKERRFGAVAC 464
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 107 bits (267), Expect = 2e-23
Identities = 76/244 (31%), Positives = 116/244 (47%), Gaps = 11/244 (4%)
Query: 185 GAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKL 244
G A + G +L GG Y+ L + + P + W +AP+ R+ F + L G+L
Sbjct: 362 GTAEMNG-KLIAAGG---YNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQL 417
Query: 245 YALGGR--HNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQ 302
Y +GG H+D L E Y+ ++ W P P L L G+LY+ GG GQ
Sbjct: 418 YVVGGSNGHSD-DLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQ 476
Query: 303 Y-LASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELR 361
L + +DP + K T +P+ + R + LGG LY+ GG L + E Y
Sbjct: 477 KGLKNCDVFDP-VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPE 535
Query: 362 TDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLP 421
++WT +AP+ GA AVL G+L V GG+ ++A+S + Y P W +G +
Sbjct: 536 NNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFD-GSHAIS-CVEMYDPTRNEWKMMGNMT 593
Query: 422 RPRA 425
PR+
Sbjct: 594 SPRS 597
Score = 89.7 bits (221), Expect = 5e-18
Identities = 65/229 (28%), Positives = 105/229 (45%), Gaps = 8/229 (3%)
Query: 167 TVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMA 226
T W L + P R R A L G +LYV GG + HS+ L+ ++ + +DW +
Sbjct: 392 TDHWSFLAPMRTP-RARFQMAVLMG-QLYVVGGSN--GHSDDLSCGEMYDSNIDDWIPVP 447
Query: 227 PLSQARSLFSLVALDGKLYALGGR--HNDVALDSVETYNPELNVWRPAPALPAPCFAHAA 284
L R + AL+GKLY +GG + L + + ++P +W L A
Sbjct: 448 ELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAV 507
Query: 285 AILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAG 344
L G LY+ GG + L ++ Y+P+ T ++PM V R G +A L G+L+V G
Sbjct: 508 CELGGYLYIIGGAE-SWNCLNTVERYNPE-NNTWTLIAPMNVARRGAGVAVLNGKLFVCG 565
Query: 345 GLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGY 393
G + + E Y+ + W + + SP A A + + +GG+
Sbjct: 566 GFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGF 614
Score = 88.2 bits (217), Expect = 1e-17
Identities = 60/198 (30%), Positives = 94/198 (47%), Gaps = 5/198 (2%)
Query: 169 EWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPL 228
+W +P L R G +L G +LY+ GG D Y L + ++P + W APL
Sbjct: 442 DWIPVPELRT-NRCNAGVCALNG-KLYIVGGSDPYGQKG-LKNCDVFDPVTKLWTSCAPL 498
Query: 229 SQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILE 288
+ R ++ L G LY +GG + L++VE YNPE N W + A+L
Sbjct: 499 NIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLN 558
Query: 289 GQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGE 348
G+L+V GG G+ ++ + YDP + + M PR+ +A +G +Y GG
Sbjct: 559 GKLFVCGGFDGS-HAISCVEMYDPTRNE-WKMMGNMTSPRSNAGIATVGNTIYAVGGFDG 616
Query: 349 TEDLLSFEAYELRTDSWT 366
E L + E Y L ++ W+
Sbjct: 617 NEFLNTVEVYNLESNEWS 634
Score = 65.5 bits (158), Expect = 1e-10
Identities = 43/125 (34%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 308 MHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTH 367
M D +EKP +SPM R+G A + G+L AGG E L + E Y TD W+
Sbjct: 341 MQQDELIEKP---MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSF 397
Query: 368 LAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEM 427
LAP+ +P AVL G+L V+GG + + LS Y + W+ + L R
Sbjct: 398 LAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLS-CGEMYDSNIDDWIPVPELRTNRCNA 456
Query: 428 PACIL 432
C L
Sbjct: 457 GVCAL 461
Score = 54.7 bits (130), Expect = 2e-07
Identities = 29/87 (33%), Positives = 49/87 (56%), Gaps = 4/87 (4%)
Query: 185 GAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKL 244
G A L G +L+VCGG D S+ ++ ++P++ +W+ M ++ RS + + +
Sbjct: 553 GVAVLNG-KLFVCGGFD---GSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTI 608
Query: 245 YALGGRHNDVALDSVETYNPELNVWRP 271
YA+GG + L++VE YN E N W P
Sbjct: 609 YAVGGFDGNEFLNTVEVYNLESNEWSP 635
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 106 bits (264), Expect = 5e-23
Identities = 132/490 (26%), Positives = 192/490 (39%), Gaps = 69/490 (14%)
Query: 6 GLERLWSKARHYLLTHLPAVALCPAFPS----LPAACLAELLDSDELHVQEEFEAFVAAR 61
GL A +++HL + A P+ L L +L + ++ E A
Sbjct: 142 GLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLAL 201
Query: 62 CWLAANPETQE-SEAKALLRCVRFGRMSTRELRRVRAAG--LLPPLTPDLLHQLMVEADV 118
WL P T+ + LL VRFG + LRRV + +LP L+ Q +
Sbjct: 202 AWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTT 261
Query: 119 PG--------QERRREPDRALVVIGGDGLR---------PDMALR--------------- 146
P Q R P ++++GG R P A R
Sbjct: 262 PSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEEL 321
Query: 147 -QPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSH 205
+ W V W L LP P H + AG+ L+V GG+ S
Sbjct: 322 EEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTP-LLGHSVCT-AGNFLFVLGGE---SP 376
Query: 206 SNTLASTL------------RWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRH-N 252
S + +S L R++P W E+ + +AR+ F A+ +L A+GG
Sbjct: 377 SGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAG 436
Query: 253 DVALDSVETYNPELNVWRPAPALPAPCFAHAAAILE-GQLYVSGGCGGTGQYLASLMH-- 309
L SVE Y+ + W A ALP HA A+ + G +Y+SGG G G+ AS +
Sbjct: 437 GEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDL 496
Query: 310 --YDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTH 367
P+ E+ + +PMG R GH MA L G ++ LG E E Y+ D WT
Sbjct: 497 YVLGPE-EQVWSKKAPMGTARFGHHMAVLRGAVFAF--LGRYEPFSEIERYDPGADQWTR 553
Query: 368 LAPLPSPHVGAASAVLQGELLVLGGYSHR--TYALSHLIHAYCPGLGRWLCLG-TLPRPR 424
L PLP AV++ L+LGG R + + Y L RW +G LP
Sbjct: 554 LRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCALPWAW 613
Query: 425 AEMPACILTL 434
+ + +L L
Sbjct: 614 SGLRCAVLQL 623
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 103 bits (258), Expect = 2e-22
Identities = 109/426 (25%), Positives = 175/426 (41%), Gaps = 39/426 (9%)
Query: 10 LWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPE 69
L +A Y H P V L F SL + L+ SD+L V E + F A W+ E
Sbjct: 167 LLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKE 226
Query: 70 TQESEAKALLRCVRFGRMSTREL-RRVRAAGLLPP--LTPDLLHQLMVEADVPGQER--- 123
T+ L+ VR + L + V L+ D L + M +P +R
Sbjct: 227 TRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLI 286
Query: 124 ---RREP------DRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLP 174
R +P + ++V+GG Q +A+ R+ C W Q+
Sbjct: 287 KNPRTKPRTPVSLPKVMIVVGG----------QAPKAI---RSVECYD--FEEDRWDQIA 331
Query: 175 ALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSL 234
LP+ R R G +AG +Y GG ++ S + + ++ ++ W +A + + RS
Sbjct: 332 ELPSR-RCRAGVVFMAG-HVYAVGG---FNGSLRVRTVDVYDGVKDQWTSIASMQERRST 386
Query: 235 FSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVS 294
L+ LYA+GG L SVE Y+ + N W + + ++EG+LY
Sbjct: 387 LGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
Query: 295 GGCGGTG-QYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLL 353
GG G Q L+++ Y+P + +++ M R+G + L G+LY GG
Sbjct: 447 GGYDGASRQCLSTVEQYNPATNE-WIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRK 505
Query: 354 SFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGR 413
S E Y+ T++W +A + A + G L V+GG S + Y P +
Sbjct: 506 SVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLAS--VEYYNPVTDK 563
Query: 414 WLCLGT 419
W L T
Sbjct: 564 WTLLPT 569
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/240 (27%), Positives = 107/240 (44%), Gaps = 12/240 (5%)
Query: 194 LYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHND 253
+ V GGQ + S ++ ++ W+++A L R +V + G +YA+GG +
Sbjct: 303 MIVVGGQA----PKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGS 358
Query: 254 VALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGC-GGTGQYLASLMHYDP 312
+ + +V+ Y+ + W ++ AA+L LY GG G TG LAS+ Y
Sbjct: 359 LRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTG--LASVEAYSY 416
Query: 313 KLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGL-GETEDLLS-FEAYELRTDSWTHLAP 370
K + F++PM R+ + + G+LY GG G + LS E Y T+ W ++A
Sbjct: 417 KTNE-WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVAD 475
Query: 371 LPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPAC 430
+ + GA VL G+L GG H + + Y PG W + + R C
Sbjct: 476 MSTRRSGAGVGVLSGQLYATGG--HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVC 533
Score = 66.2 bits (160), Expect = 6e-11
Identities = 48/188 (25%), Positives = 84/188 (44%), Gaps = 3/188 (1%)
Query: 238 VALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGC 297
V+L + +GG+ A+ SVE Y+ E + W LP+ + G +Y GG
Sbjct: 297 VSLPKVMIVVGGQAPK-AIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF 355
Query: 298 GGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEA 357
G+ + + ++ YD ++ T ++ M R+ A L LY GG + L S EA
Sbjct: 356 NGSLR-VRTVDVYDG-VKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEA 413
Query: 358 YELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCL 417
Y +T+ W +AP+ + V++G+L +GGY + + Y P W+ +
Sbjct: 414 YSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYV 473
Query: 418 GTLPRPRA 425
+ R+
Sbjct: 474 ADMSTRRS 481
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 102 bits (255), Expect = 5e-22
Identities = 108/441 (24%), Positives = 178/441 (40%), Gaps = 36/441 (8%)
Query: 14 ARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQES 73
+ +Y+ H V F +L L ++L S+EL +++E++ F+AA W+ + +
Sbjct: 158 SENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRK 217
Query: 74 EAKALLRCVRFGRMSTRELRRVRAAGL----LPPLTPDLLHQLMVEADVPGQER------ 123
+L +RF + + L + G+ L LL + P + +
Sbjct: 218 HVVEVLDPIRFPLLPPQRLLKY-IEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQ 276
Query: 124 ------RREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALP 177
R++ + L +GG R SRA+ F + W + +L
Sbjct: 277 TSKVRPRKKARKYLYAVGGY-TRLQGGRWSDSRALSCVERFD-----TFSQYWTTVSSLH 330
Query: 178 APGRFRHG-AASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFS 236
+ R G ++ G +Y GG+ S T ++P + W +A ++ R
Sbjct: 331 ---QARSGLGVTVLGGMVYAIGGE---KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
Query: 237 LVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGG 296
+ G +YALGG +++E ++P+ N W + + ++G +YV GG
Sbjct: 385 VCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG 444
Query: 297 CGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLL-SF 355
G L S YDP L K + L PMG RA +AAL +Y GG ET+D L +
Sbjct: 445 ISNEGIELRSFEVYDP-LSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
Query: 356 EAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGG--YSHRTYALSHL--IHAYCPGL 411
E Y + W +A + P G + G L V GG SH A L + Y P
Sbjct: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHS 563
Query: 412 GRWLCLGTLPRPRAEMPACIL 432
W +G + R E +L
Sbjct: 564 DTWTEIGNMITSRCEGGVAVL 584
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 101 bits (252), Expect = 1e-21
Identities = 95/413 (23%), Positives = 163/413 (39%), Gaps = 37/413 (8%)
Query: 9 RLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANP 68
RL AR ++ + F L L ++ +D L+V++E F A W+ +
Sbjct: 149 RLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDK 208
Query: 69 ETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEAD-----VPGQER 123
E + + C+RF M+ + + + PDL ++ V D +P +
Sbjct: 209 ENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSK 268
Query: 124 RREPDRALVV---IGGDGLRPDMALRQPSRAVWWARAF-----RCGVGLVRTVEWGQLPA 175
A V +G + L P P ++ V T L A
Sbjct: 269 NAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTA 328
Query: 176 LPAPGRFRHGAASLAGSELYVCGG------------QDFYSHSNTLASTLRWEPSQEDWE 223
L H + +++YV GG Q ++ +++AS +W
Sbjct: 329 LAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS---------EWV 379
Query: 224 EMAPLSQARSLFSLVALDGKLYALGGR--HNDVALDSVETYNPELNVWRPAPALPAPCFA 281
+ PL AR LF L +D K+Y + G+ + +LDSV Y+P W LP +
Sbjct: 380 GLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYG 439
Query: 282 HAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLY 341
H +G +Y GG + + ++PK + L+PM +PR+ +A G++
Sbjct: 440 HNVISHKGMIYCLGGKTDDKKCTNRVFIFNPK-KGDWKDLAPMKIPRSMFGVAVHKGKIV 498
Query: 342 VAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYS 394
+AGG+ E S EA++L T+ W + P + L G L +GG++
Sbjct: 499 IAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFA 551
Score = 32.7 bits (73), Expect = 0.69
Identities = 26/102 (25%), Positives = 42/102 (41%), Gaps = 6/102 (5%)
Query: 326 VPRAGHVMAALGGRLYVAGGLGETEDLLS--FEAYELRTDS----WTHLAPLPSPHVGAA 379
+PR + ++YV GGL E+ ++Y + DS W L PLPS
Sbjct: 333 IPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFG 392
Query: 380 SAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLP 421
+ ++ V+ G +T A + Y P +W + LP
Sbjct: 393 LGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLP 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,454,198
Number of Sequences: 37866
Number of extensions: 1037530
Number of successful extensions: 3232
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2258
Number of HSP's gapped (non-prelim): 325
length of query: 453
length of database: 18,247,518
effective HSP length: 106
effective length of query: 347
effective length of database: 14,233,722
effective search space: 4939101534
effective search space used: 4939101534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.