Guide to the Human Genome
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Search of human proteins with 157694526

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157694526 Fc receptor-like 5 [Homo sapiens]
         (977 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157694526 Fc receptor-like 5 [Homo sapiens]                       1974   0.0  
gi|21314764 Fc receptor-like 3 precursor [Homo sapiens]               452   e-127
gi|14550416 Fc receptor-like 4 precursor [Homo sapiens]               319   7e-87
gi|19923629 Fc receptor-like 2 precursor [Homo sapiens]               293   4e-79
gi|226958551 Fc receptor-like 1 isoform 3 precursor [Homo sapiens]    242   1e-63
gi|16418419 Fc receptor-like 1 isoform 1 precursor [Homo sapiens]     240   4e-63
gi|226958547 Fc receptor-like 1 isoform 2 precursor [Homo sapiens]    207   4e-53
gi|50878302 Fc receptor-like B [Homo sapiens]                         166   1e-40
gi|10835133 Fc fragment of IgG, high affinity Ia, receptor (CD64...   157   5e-38
gi|157057547 Fc receptor-like 6 [Homo sapiens]                        133   7e-31
gi|69885149 Fc receptor-like and mucin-like 1 [Homo sapiens]          124   6e-28
gi|110349719 titin isoform N2-A [Homo sapiens]                        113   1e-24
gi|50511926 Fc fragment of IgG, low affinity IIb, receptor isofo...   112   2e-24
gi|50511930 Fc fragment of IgG, low affinity IIb, receptor isofo...   112   2e-24
gi|118572606 hemicentin 1 [Homo sapiens]                              112   2e-24
gi|126116592 Fc fragment of IgG, low affinity IIc, receptor [Hom...   111   3e-24
gi|132814489 low affinity immunoglobulin gamma Fc region recepto...   110   6e-24
gi|110347451 platelet/endothelial cell adhesion molecule [Homo s...   109   1e-23
gi|50511928 Fc fragment of IgG, low affinity IIb, receptor isofo...   108   3e-23
gi|50511932 Fc fragment of IgG, low affinity IIb, receptor isofo...   108   3e-23
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            107   4e-23
gi|189083840 Fc fragment of IgG, low affinity IIIa, receptor (CD...   107   7e-23
gi|189083838 Fc fragment of IgG, low affinity IIIa, receptor (CD...   107   7e-23
gi|189083836 Fc fragment of IgG, low affinity IIIa, receptor (CD...   107   7e-23
gi|50726979 Fc fragment of IgG, low affinity IIIa, receptor (CD1...   107   7e-23
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   107   7e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   107   7e-23
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   107   7e-23
gi|189083842 Fc fragment of IgG, low affinity IIIa, receptor (CD...   106   1e-22
gi|4503675 Fc fragment of IgE, high affinity I, receptor for; al...   103   8e-22

>gi|157694526 Fc receptor-like 5 [Homo sapiens]
          Length = 977

 Score = 1974 bits (5115), Expect = 0.0
 Identities = 977/977 (100%), Positives = 977/977 (100%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR
Sbjct: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60

Query: 61  YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120
           YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV
Sbjct: 61  YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120

Query: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180
           LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT
Sbjct: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180

Query: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240
           VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS
Sbjct: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240

Query: 241 LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE 300
           LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE
Sbjct: 241 LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE 300

Query: 301 GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG 360
           GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG
Sbjct: 301 GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG 360

Query: 361 LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA 420
           LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA
Sbjct: 361 LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA 420

Query: 421 LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA 480
           LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA
Sbjct: 421 LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA 480

Query: 481 EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY 540
           EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY
Sbjct: 481 EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY 540

Query: 541 CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF 600
           CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF
Sbjct: 541 CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF 600

Query: 601 YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI 660
           YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI
Sbjct: 601 YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI 660

Query: 661 LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE 720
           LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE
Sbjct: 661 LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE 720

Query: 721 HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP 780
           HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP
Sbjct: 721 HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP 780

Query: 781 LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL 840
           LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL
Sbjct: 781 LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL 840

Query: 841 TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH 900
           TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH
Sbjct: 841 TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH 900

Query: 901 NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA 960
           NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA
Sbjct: 901 NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA 960

Query: 961 STPVSGSLFLASSAPHR 977
           STPVSGSLFLASSAPHR
Sbjct: 961 STPVSGSLFLASSAPHR 977


>gi|21314764 Fc receptor-like 3 precursor [Homo sapiens]
          Length = 734

 Score =  452 bits (1163), Expect = e-127
 Identities = 257/567 (45%), Positives = 332/567 (58%), Gaps = 11/567 (1%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ-KTKWYH 59
           MLLW++LL+L P   Q    P+ ++ L PPW+T F+GE+V L C        Q  T WYH
Sbjct: 1   MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYH 60

Query: 60  RYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSV 119
               +++L+   D I ++ E G Y+C+ +GS LS  VH++FS   LILQA   VFEGD+V
Sbjct: 61  ---DEKLLKIKHDKI-QITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNV 116

Query: 120 VLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCC---PV 176
           +LRC+ K     +  +Y  D      +   +    ++  +DN  Y CT Y++       V
Sbjct: 117 ILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEV 176

Query: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236
           +S  + IQVQE F  PVLRASS  PI G+P+TLTCETQLS +R DV L+F  FRD QTLG
Sbjct: 177 TSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLG 236

Query: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ-IPASHPVLTLSPEK 295
           LGWS SP  QI AMW++DSG YWC+  T+ +S+   S RS I+VQ +P S+  L + P  
Sbjct: 237 LGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTG 296

Query: 296 ALNFEGTKVTLHCETQEDSLRTLYRFYHEG--VPLRHKSVRCERGASISFSLTTENSGNY 353
               EG  + L C   + S    + ++ EG    L  K+ R         ++   ++G Y
Sbjct: 297 GQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRY 356

Query: 354 YCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQ 413
           YC ADN      S  + ++V +PVSHPVL   +P      G  + LHCE+ RGS PILY+
Sbjct: 357 YCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYR 416

Query: 414 FHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHP 473
           F+HE   L   SA S GG + + SLTAEHSGNY C ADNG G Q S  VSL VTVPVS P
Sbjct: 417 FYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRP 476

Query: 474 VLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTE 533
           VLTL +  A    G  + LHCE  RGS  ILY FYHED  L + S  S G  SF+ SLT 
Sbjct: 477 VLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTT 536

Query: 534 GHSGNYYCTADNGFGPQRSEVVSLFVT 560
            HSGNY C ADNG G Q S+VV+L VT
Sbjct: 537 EHSGNYSCEADNGLGAQHSKVVTLNVT 563



 Score =  420 bits (1079), Expect = e-117
 Identities = 294/711 (41%), Positives = 383/711 (53%), Gaps = 70/711 (9%)

Query: 284 ASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRF-YHEGVPLRHKSVRCERGASIS 342
           A   VL L+P  +  F+G KV L C +   SL     + YH+   L+ K  + +      
Sbjct: 20  APKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQ------ 73

Query: 343 FSLTTENSGNYYCTADNGLGAKPSKAVSLSVT-----VPVSHPVLNLSSPEDLIFEGAKV 397
                   GNY C      G+  S AV +  +     +   HPV          FEG  V
Sbjct: 74  ----ITEPGNYQCKTR---GSSLSDAVHVEFSPDWLILQALHPV----------FEGDNV 116

Query: 398 TLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG-- 455
            L C+ +         ++ +G  L     NS     I+ +  +  +  Y+CTA   F   
Sbjct: 117 ILRCQGKDNKNTHQKVYYKDGKQLP----NSYNLEKITVNSVSRDNSKYHCTAYRKFYIL 172

Query: 456 --PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ----RGSPQILYQFYH 509
                SK +++ V     HPVL  SS+  +  EG+ +TL CE Q    R   Q+ +  + 
Sbjct: 173 DIEVTSKPLNIQVQELFLHPVLRASSSTPI--EGSPMTLTCETQLSPQRPDVQLQFSLFR 230

Query: 510 EDMPL---WSSSTPSVGRVSFSFSLTEGHSGNYYC---TADNGFGPQRSEVVSLFVTVPV 563
           +   L   WS S     R+      TE  SG+Y+C   T  +    +          VPV
Sbjct: 231 DSQTLGLGWSRSP----RLQIPAMWTED-SGSYWCEVETVTHSIKKRSLRSQIRVQRVPV 285

Query: 564 SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDV--TLGSSSAPSGGEASFN 621
           S   L +R    Q + G+ + L C   +GS  + + ++ E    +LG  +  S       
Sbjct: 286 SNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHV 345

Query: 622 LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681
           L++    +G Y C A+N      S  I ++V +PVS P+LTFRAPRA  VVGDLLELHCE
Sbjct: 346 LTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCE 405

Query: 682 ALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMV 741
           +LRGS PILY FYHEDVTLG  SAPSGGGASFNLSLT EHSG YSC+ADNGL AQ S  V
Sbjct: 406 SLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGV 465

Query: 742 TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS- 800
           +L+V VPVSRPVLTLRAPG  A VGDLLELHCE+LRGS  ILY F+HED TLGN S+ S 
Sbjct: 466 SLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSG 525

Query: 801 GGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIA 860
           GGAS NLSLT EHSGNYSCEADNGLGAQ S+ VTL +TG + NR+G  A G+ G +LSI 
Sbjct: 526 GGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSIL 585

Query: 861 GLAAGALLL-YCWLSRKAGRKPAS-----------DPARS-PSDSDSQEPTYHNVPAWEE 907
            LAA A LL Y    RK G   A+           +P+ S PS  D QEPT+    A  E
Sbjct: 586 VLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPME 645

Query: 908 LQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVK 958
           L+P+Y+N NP   N +YS++  IQ  K+++      H  ++   ++YSE+K
Sbjct: 646 LEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELK 696



 Score =  371 bits (953), Expect = e-102
 Identities = 237/537 (44%), Positives = 308/537 (57%), Gaps = 36/537 (6%)

Query: 254 DSGFYWCKA--ATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQ 311
           + G Y CK   +++  +V  +    W+ +Q  A HPV          FEG  V L C+ +
Sbjct: 76  EPGNYQCKTRGSSLSDAVHVEFSPDWLILQ--ALHPV----------FEGDNVILRCQGK 123

Query: 312 EDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSL 371
           ++       +Y +G  L + S   E+   I+ +  + ++  Y+CTA         +  S 
Sbjct: 124 DNKNTHQKVYYKDGKQLPN-SYNLEK---ITVNSVSRDNSKYHCTAYRKFYILDIEVTSK 179

Query: 372 SVTVPVS----HPVLNLSSPEDLIFEGAKVTLHCEAQ----RGSLPILYQFHHEGAALER 423
            + + V     HPVL  SS   +  EG+ +TL CE Q    R  + + +    +   L  
Sbjct: 180 PLNIQVQELFLHPVLRASSSTPI--EGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGL 237

Query: 424 RSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV---PVSHPVLTLSSA 480
             + S   + I  ++  E SG+Y+C  +      + +++   + V   PVS+  L +   
Sbjct: 238 GWSRSPR-LQIP-AMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPT 295

Query: 481 EALTFEGATVTLHCEVQRGSPQILYQFYHEDM--PLWSSSTPSVGRVSFSFSLTEGHSGN 538
                EG  + L C V +GS  + + ++ E     L   +  S+       ++ E  +G 
Sbjct: 296 GGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGR 355

Query: 539 YYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY 598
           YYC ADN   P  S  + + V +PVS P+LT R PRA  VVGDLLELHCE+ RGSPPILY
Sbjct: 356 YYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILY 415

Query: 599 WFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSR 658
            FYHEDVTLG+SSAPSGG ASFNLSLTAEHSGNYSC+A+NGL AQHS  +SL V VPVSR
Sbjct: 416 RFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSR 475

Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLT 718
           P+LT RAP AQAVVGDLLELHCE+LRGS PILYWFYHED TLG ISA SGGGASFNLSLT
Sbjct: 476 PVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLT 535

Query: 719 TEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEA 775
           TEHSG YSCEADNGL AQ S++VTL V    SR    L A G    V  +L L   A
Sbjct: 536 TEHSGNYSCEADNGLGAQHSKVVTLNV-TGTSRNRTGLTAAGITGLVLSILVLAAAA 591


>gi|14550416 Fc receptor-like 4 precursor [Homo sapiens]
          Length = 515

 Score =  319 bits (818), Expect = 7e-87
 Identities = 177/379 (46%), Positives = 226/379 (59%), Gaps = 6/379 (1%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  LL  APV GQ A   +P+I + PPWTT F+GERVTLTC GF+FY+ +KT WYHR
Sbjct: 1   MLLWASLLAFAPVCGQSAAAHKPVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHR 60

Query: 61  YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120
           +   E L  TP N LEV+ESG YRCQA+GSP S+PV L FSS SLILQAP SVFEGD++V
Sbjct: 61  HYWGEKLTLTPGNTLEVRESGLYRCQARGSPRSNPVRLLFSSDSLILQAPYSVFEGDTLV 120

Query: 121 LRCRAKAEVTLNNTIYK-NDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSN 179
           LRC  + +  L    Y  N N+L+  NK  D  IP A   +NG YRC GY +      SN
Sbjct: 121 LRCHRRRKEKLTAVKYTWNGNILSISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSN 180

Query: 180 TVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW 239
              I++QE F  P L+A+  QP  GN V L+CETQL  ERSD PL F FFRD + +   W
Sbjct: 181 FKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVILSDW 240

Query: 240 SLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ-IPASHPVLTLSPEKALN 298
           S  P  Q+  +W ++SG YWC A T+  ++   SP   I VQ IP S  +L   P     
Sbjct: 241 STYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQA 300

Query: 299 FEGTKVTLHCETQEDSLRTLYRFYHEGV--PLRHKSVRCERGASISFSLTTENSGNYYCT 356
            EG  + L C   E +  T + ++ E +   L  K+ R  R      ++   ++G YYCT
Sbjct: 301 VEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCT 360

Query: 357 ADNGLGAKPSKAVSLSVTV 375
           ADN  G  P +++ L+VTV
Sbjct: 361 ADNSYG--PVQSMVLNVTV 377



 Score =  129 bits (324), Expect = 1e-29
 Identities = 142/508 (27%), Positives = 220/508 (43%), Gaps = 55/508 (10%)

Query: 473 PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFS--FS 530
           PV+++       F+G  VTL C          +QFY  +   W        +++ +   +
Sbjct: 23  PVISVHPPWTTFFKGERVTLTCNG--------FQFYATEKTTWYHRHYWGEKLTLTPGNT 74

Query: 531 LTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAP 590
           L    SG Y C A    G  RS  V L      S   L L+ P +    GD L L C   
Sbjct: 75  LEVRESGLYRCQAR---GSPRSNPVRLLF----SSDSLILQAPYS-VFEGDTLVLRCHRR 126

Query: 591 RGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSL---TAEHSGNYSCEA---NNGLVAQH 644
           R        +      L  S+       S++L +   ++ ++GNY C      N +   +
Sbjct: 127 RKEKLTAVKYTWNGNILSISNK------SWDLLIPQASSNNNGNYRCIGYGDENDVFRSN 180

Query: 645 SDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEAL----RGSSPILYWFYHE-DVT 699
              I +  + P   P L  +A  +Q   G+ + L CE      R  +P+ + F+ + +V 
Sbjct: 181 FKIIKIQELFP--HPEL--KATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVI 236

Query: 700 LGKISAPSGGGASFNLSLTT---EHSGIYSCEADN--GLEAQRSEMVTLKVA-VPVSRPV 753
           L   S          L L T   E+SG Y C A+   G   + S  + + V  +PVS  +
Sbjct: 237 LSDWSTYP------ELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVL 290

Query: 754 LTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDV--TLGNRSSPSGGASLNL-SLT 810
           L  +  G  A  G++L L C    G+    + +  ED+  +LG ++  S  A L L ++ 
Sbjct: 291 LETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIR 350

Query: 811 AEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLY 870
             H+G Y C ADN  G  +S  + + +     NR G  A G  GGLLS A L A ALL +
Sbjct: 351 QSHAGGYYCTADNSYGPVQSMVLNVTVRETPGNRDGLVAAGATGGLLS-ALLLAVALLFH 409

Query: 871 CWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRII 930
           CW  RK+G     D  R P      E ++   PA  ELQ +Y + +P+  ++VYSE++  
Sbjct: 410 CWRRRKSGVGFLGDETRLPPAPGPGESSHSICPAQVELQSLYVDVHPKKGDLVYSEIQTT 469

Query: 931 QEKKKHAVASDPRHLRNKGSPIIYSEVK 958
           Q  ++    +    L +K   ++YSEVK
Sbjct: 470 QLGEEEEANTSRTLLEDKDVSVVYSEVK 497



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 95/375 (25%), Positives = 156/375 (41%), Gaps = 53/375 (14%)

Query: 204 GNPVTLTCETQLSLERSDVPLRFRFFRDDQTL-------GLGWSLSPNFQITAMWSKDSG 256
           G  VTLTC              F+F+  ++T        G   +L+P   +     ++SG
Sbjct: 37  GERVTLTCNG------------FQFYATEKTTWYHRHYWGEKLTLTPGNTLEV---RESG 81

Query: 257 FYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLR 316
            Y C+A          SPRS     + +S  ++  +P     FEG  + L C  +     
Sbjct: 82  LYRCQAR--------GSPRSNPVRLLFSSDSLILQAPYSV--FEGDTLVLRCHRRRKEKL 131

Query: 317 TLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTA---DNGLGAKPSKAVSLSV 373
           T  ++   G  L   S+  +    +    ++ N+GNY C     +N +     K + +  
Sbjct: 132 TAVKYTWNGNIL---SISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSNFKIIKIQE 188

Query: 374 TVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQ----RGSLPILYQFHHEGAALERRSANSA 429
             P  HP L  +  +    EG  V L CE Q    R   P+ + F  +G  +   S  S 
Sbjct: 189 LFP--HPELKATDSQPT--EGNSVNLSCETQLPPERSDTPLHFNFFRDGEVI--LSDWST 242

Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV---PVSHPVLTLSSAEALTFE 486
                  ++  E+SG+Y+C A+   G     + SL + V   PVS  +L    +     E
Sbjct: 243 YPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQAVE 302

Query: 487 GATVTLHCEVQRGSPQILYQFYHEDM--PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTAD 544
           G  + L C V  G+    + ++ EDM   L   +  S+       ++ + H+G YYCTAD
Sbjct: 303 GEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCTAD 362

Query: 545 NGFGPQRSEVVSLFV 559
           N +GP +S V+++ V
Sbjct: 363 NSYGPVQSMVLNVTV 377



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 95/389 (24%), Positives = 159/389 (40%), Gaps = 57/389 (14%)

Query: 380 PVLNLSSPEDLIFEGAKVTLHC---EAQRGSLPILYQFHHEGAALERRSANSAGGVAISF 436
           PV+++  P    F+G +VTL C   +         Y  H+ G  L     N         
Sbjct: 23  PVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHRHYWGEKLTLTPGN--------- 73

Query: 437 SLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEAL-------TFEGAT 489
           +L    SG Y C A                  P S+PV  L S+++L        FEG T
Sbjct: 74  TLEVRESGLYRCQARGS---------------PRSNPVRLLFSSDSLILQAPYSVFEGDT 118

Query: 490 VTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHS---GNYYCTADNG 546
           + L C  +R       ++       W+ +  S+   S+   + +  S   GNY C    G
Sbjct: 119 LVLRCHRRRKEKLTAVKY------TWNGNILSISNKSWDLLIPQASSNNNGNYRCI---G 169

Query: 547 FGPQRSEVVSLFVTVPVSR--PILTLRVPRAQAVVGDLLELHCEA---PRGSPPILYWFY 601
           +G +     S F  + +    P   L+   +Q   G+ + L CE    P  S   L++ +
Sbjct: 170 YGDENDVFRSNFKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNF 229

Query: 602 HEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSC--EANNGLVAQHSDTISLSV-IVPVSR 658
             D  +  S   +  E     ++  E+SG+Y C  E   G + +HS ++ + V  +PVS 
Sbjct: 230 FRDGEVILSDWSTYPELQLP-TVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSG 288

Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDV--TLGKISAPSGGGASFNLS 716
            +L  +    QAV G++L L C    G+    + ++ ED+  +LG+ +  S        +
Sbjct: 289 VLLETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPA 348

Query: 717 LTTEHSGIYSCEADNGLEAQRSEMVTLKV 745
           +   H+G Y C ADN     +S ++ + V
Sbjct: 349 IRQSHAGGYYCTADNSYGPVQSMVLNVTV 377



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 78/324 (24%), Positives = 135/324 (41%), Gaps = 38/324 (11%)

Query: 158 LKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL 217
           ++++G YRC           SN V++         ++  + +    G+ + L C  +   
Sbjct: 77  VRESGLYRCQARGSP----RSNPVRLLFSSD---SLILQAPYSVFEGDTLVLRCHRR--- 126

Query: 218 ERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRS- 276
            R +     ++  +   L +  + S +  I    S ++G Y C    + Y   +D  RS 
Sbjct: 127 -RKEKLTAVKYTWNGNILSIS-NKSWDLLIPQASSNNNGNYRC----IGYGDENDVFRSN 180

Query: 277 --WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRT----LYRFYHEGVPLRH 330
              I++Q    HP L  +  +    EG  V L CETQ    R+     + F+ +G     
Sbjct: 181 FKIIKIQELFPHPELKATDSQPT--EGNSVNLSCETQLPPERSDTPLHFNFFRDG----- 233

Query: 331 KSVRCERGASISFSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTV---PVSHPVLNL 384
           + +  +        L T   ENSG+Y+C A+   G     + SL + V   PVS  +L  
Sbjct: 234 EVILSDWSTYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLET 293

Query: 385 SSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGA--ALERRSANSAGGVAISFSLTAEH 442
                   EG  + L C    G+    + +H E    +L R++  S        ++   H
Sbjct: 294 QPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSH 353

Query: 443 SGNYYCTADNGFGPQRSKAVSLSV 466
           +G YYCTADN +GP +S  ++++V
Sbjct: 354 AGGYYCTADNSYGPVQSMVLNVTV 377


>gi|19923629 Fc receptor-like 2 precursor [Homo sapiens]
          Length = 508

 Score =  293 bits (751), Expect = 4e-79
 Identities = 172/371 (46%), Positives = 221/371 (59%), Gaps = 5/371 (1%)

Query: 104 SLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNV-LAFLNKRTDFHIPHACLKDNG 162
           SL L AP SVFEGDS+VL+C+ +    +    Y  DN  L+   K +DF I  A L D+G
Sbjct: 19  SLTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSG 78

Query: 163 AYRC-TGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSD 221
            Y C T  +      +SN VKI+VQE F RPVL ASSFQPI G PV+L CET+LS +R D
Sbjct: 79  NYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLD 138

Query: 222 VPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ 281
           V L+F FFR++Q LG GWS SP  QI+A+WS+D+G YWCKA T+ + +   S +S I VQ
Sbjct: 139 VQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQ 198

Query: 282 -IPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHE--GVPLRHKSVRCERG 338
            IP S+  L +        EG K+ L C     +    + +Y E  G  +  K+ R    
Sbjct: 199 RIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSA 258

Query: 339 ASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVT 398
                ++   ++G YYC ADNG     SK V++ V +PVS PVL L SP      G  + 
Sbjct: 259 ELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLE 318

Query: 399 LHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQR 458
           LHCEA RGS PILYQF+HE   L   SA S GG + + SLTAEHSGNY C A+NG G Q 
Sbjct: 319 LHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQC 378

Query: 459 SKAVSLSVTVP 469
           S+AV +S++ P
Sbjct: 379 SEAVPVSISGP 389



 Score =  275 bits (703), Expect = 2e-73
 Identities = 197/499 (39%), Positives = 265/499 (53%), Gaps = 36/499 (7%)

Query: 480 AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF---SLTEGHS 536
           A +  FEG ++ L C+ ++   +I    YH+D     +   SV +    F   S     S
Sbjct: 24  APSSVFEGDSIVLKCQGEQNW-KIQKMAYHKD-----NKELSVFKKFSDFLIQSAVLSDS 77

Query: 537 GNYYCTADNGF--GPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSP 594
           GNY+C+         + S +V + V     RP+LT      Q + G  + L CE  R SP
Sbjct: 78  GNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLT--ASSFQPIEGGPVSLKCET-RLSP 134

Query: 595 PIL-----YWFYHEDVTLGSSSAPSGGEASFNLSLTA---EHSGNYSCEANNGLVAQHSD 646
             L     + F+ E+  LGS     G  +S  L ++A   E +G+Y C+A          
Sbjct: 135 QRLDVQLQFCFFRENQVLGS-----GWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQ 189

Query: 647 TISLSVIV---PVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHE--DVTLG 701
           ++   + V   P+S   L  RAP  Q   G  L L C    G+  + + +Y E    ++G
Sbjct: 190 SLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMG 249

Query: 702 KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGT 761
           K +  S        ++    +G Y C ADNG    +S++V + V +PVSRPVLTLR+PG 
Sbjct: 250 KKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGA 309

Query: 762 HAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGG-ASLNLSLTAEHSGNYSCE 820
            AAVGDLLELHCEALRGSP ILY+F+HEDVTLGN S+PSGG AS NLSLTAEHSGNYSCE
Sbjct: 310 QAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCE 369

Query: 821 ADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRK 880
           A+NGLGAQ SE V + I+G    R      GV  GL  + G    ALLLY    + +G  
Sbjct: 370 ANNGLGAQCSEAVPVSISGPDGYRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGES 429

Query: 881 PASDPARSPSDSDSQEPTYHN-VPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVA 939
            A++  R  S  + QE TY +  P  EELQPVY N      +VVYS+V  +Q+ +  + A
Sbjct: 430 SATNEPRGASRPNPQEFTYSSPTPDMEELQPVYVNVGSVDVDVVYSQVWSMQQPE--SSA 487

Query: 940 SDPRHLRNKGSPIIYSEVK 958
           +    L NK S +IYS VK
Sbjct: 488 NIRTLLENKDSQVIYSSVK 506



 Score =  226 bits (576), Expect = 8e-59
 Identities = 147/368 (39%), Positives = 207/368 (56%), Gaps = 18/368 (4%)

Query: 299 FEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTAD 358
           FEG  + L C+ +++       ++ +   L   SV  +    +  S    +SGNY+C+  
Sbjct: 29  FEGDSIVLKCQGEQNWKIQKMAYHKDNKEL---SVFKKFSDFLIQSAVLSDSGNYFCSTK 85

Query: 359 NGLGA--KPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEA----QRGSLPILY 412
             L    K S  V + V      PVL  SS + +  EG  V+L CE     QR  + + +
Sbjct: 86  GQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPI--EGGPVSLKCETRLSPQRLDVQLQF 143

Query: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV---P 469
            F  E   L     +S+  + IS ++ +E +G+Y+C A+      R +++   + V   P
Sbjct: 144 CFFRENQVLGS-GWSSSPELQIS-AVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQRIP 201

Query: 470 VSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHE--DMPLWSSSTPSVGRVSF 527
           +S+  L + +      EG  + L C V  G+  + + +Y E     +   +  S+     
Sbjct: 202 ISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSAELE 261

Query: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587
             ++ E  +G YYC ADNG  P +S+VV++ V +PVSRP+LTLR P AQA VGDLLELHC
Sbjct: 262 IPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHC 321

Query: 588 EAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDT 647
           EA RGSPPILY FYHEDVTLG+SSAPSGG ASFNLSLTAEHSGNYSCEANNGL AQ S+ 
Sbjct: 322 EALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEA 381

Query: 648 ISLSVIVP 655
           + +S+  P
Sbjct: 382 VPVSISGP 389



 Score =  218 bits (556), Expect = 2e-56
 Identities = 162/437 (37%), Positives = 220/437 (50%), Gaps = 31/437 (7%)

Query: 382 LNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAE 441
           L L +P   +FEG  + L C+ ++        +H +   L   S        +  S    
Sbjct: 20  LTLVAPSS-VFEGDSIVLKCQGEQNWKIQKMAYHKDNKEL---SVFKKFSDFLIQSAVLS 75

Query: 442 HSGNYYCTADNGF--GPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEV--- 496
            SGNY+C+         + S  V + V      PVLT SS + +  EG  V+L CE    
Sbjct: 76  DSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPI--EGGPVSLKCETRLS 133

Query: 497 -QRGSPQILYQFYHEDMPLWS--SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSE 553
            QR   Q+ + F+ E+  L S  SS+P + ++S  +S     +G+Y+C A+      R +
Sbjct: 134 PQRLDVQLQFCFFRENQVLGSGWSSSPEL-QISAVWS---EDTGSYWCKAETVTHRIRKQ 189

Query: 554 VVSLFVTV---PVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS 610
            +   + V   P+S   L +R P  Q   G  L L C    G+  + + +Y E  T  S 
Sbjct: 190 SLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYRE-ATGTSM 248

Query: 611 SAPSGGEASFNLSLTA---EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPR 667
              +    S  L + A     +G Y C A+NG V   S  +++ V +PVSRP+LT R+P 
Sbjct: 249 GKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPG 308

Query: 668 AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSC 727
           AQA VGDLLELHCEALRGS PILY FYHEDVTLG  SAPSGGGASFNLSLT EHSG YSC
Sbjct: 309 AQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSC 368

Query: 728 EADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFF 787
           EA+NGL AQ SE V + ++ P       + A       G L         G  L+LY  F
Sbjct: 369 EANNGLGAQCSEAVPVSISGPDGYRRDLMTAGVLWGLFGVL------GFTGVALLLYALF 422

Query: 788 HEDVTLGNRSSPSGGAS 804
           H+     + ++   GAS
Sbjct: 423 HKISGESSATNEPRGAS 439



 Score =  126 bits (316), Expect = 1e-28
 Identities = 115/401 (28%), Positives = 184/401 (45%), Gaps = 37/401 (9%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW +L++   V+ Q        + L  P ++VF+G+ + L C+G + +  QK  ++  
Sbjct: 1   MLLWSLLVIFDAVTEQ-----ADSLTLVAP-SSVFEGDSIVLKCQGEQNWKIQKMAYHKD 54

Query: 61  YLGKEILRETPDNILE---VQESGEYRCQAQG-----SPLSSPVHL---DFSSASLILQA 109
                + ++  D +++   + +SG Y C  +G        S+ V +   +     ++  +
Sbjct: 55  NKELSVFKKFSDFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTAS 114

Query: 110 PLSVFEGDSVVLRCRA-----KAEVTLNNTIYKNDNVL-AFLNKRTDFHIPHACLKDNGA 163
                EG  V L+C       + +V L    ++ + VL +  +   +  I     +D G+
Sbjct: 115 SFQPIEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGS 174

Query: 164 YRCTGYKES-CCPVSSNTVKIQVQE-PFTRPVL--RASSFQPISGNPVTLTCETQLSLER 219
           Y C     +      S   +I VQ  P +   L  RA   Q   G  + L C    S+  
Sbjct: 175 YWCKAETVTHRIRKQSLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLC----SVAG 230

Query: 220 SDVPLRFRFFRDDQTLGLG----WSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPR 275
               + F ++R+     +G     SLS   +I A+   D+G Y+C+A      + S    
Sbjct: 231 GTGNVTFSWYREATGTSMGKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVN 290

Query: 276 SWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRC 335
             I V+IP S PVLTL    A    G  + LHCE    S   LY+FYHE V L + S   
Sbjct: 291 --IPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPS 348

Query: 336 ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVP 376
             GAS + SLT E+SGNY C A+NGLGA+ S+AV +S++ P
Sbjct: 349 GGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGP 389


>gi|226958551 Fc receptor-like 1 isoform 3 precursor [Homo sapiens]
          Length = 428

 Score =  242 bits (617), Expect = 1e-63
 Identities = 169/418 (40%), Positives = 222/418 (53%), Gaps = 19/418 (4%)

Query: 557 LFVTVPVSRPI-LTLRVPRAQAVVGDLLELHCEAP---RGSPPILYWFYHEDVTLGSSSA 612
           L +  P+  P  L L    +    G  + L C+ P          + F+ +   LG    
Sbjct: 7   LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP--- 63

Query: 613 PSGGEASFNLSLTA---EHSGNYSCEAN---NGLVAQHSDTISLSVIVPVSRPILTFRAP 666
             G  +S  L + A   E +G+Y CEA    + ++      I++   VPV+   L  + P
Sbjct: 64  --GWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHR-VPVADVSLETQPP 120

Query: 667 RAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG-GASFNL-SLTTEHSGI 724
             Q + GD L L C    G+  I + +Y   V L   S       A + + S+    +  
Sbjct: 121 GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180

Query: 725 YSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILY 784
           Y C A+NG     S +V++ V +PVSRP+L LRAP   AAV D+LELHCEALRGSP ILY
Sbjct: 181 YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY 240

Query: 785 RFFHEDVTLGNRSSPSGG-ASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTAN 843
            F+HED+TLG+RS+PSGG AS NLSLT EHSGNYSCEA+NGLGAQRSE VTL  T  T  
Sbjct: 241 WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGA 300

Query: 844 RSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVP 903
           RS    +GV  GLLS  G A  ALL    L RK GR+ A DP RS      QE TY N P
Sbjct: 301 RSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSP 360

Query: 904 AWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVAS 961
              +LQP+Y N N    + VYS     Q +++    +   H+ +K S  IYS ++ A+
Sbjct: 361 TPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAETLGTHMEDKVSLDIYSRLRKAN 418



 Score =  211 bits (538), Expect = 2e-54
 Identities = 122/280 (43%), Positives = 161/280 (57%), Gaps = 7/280 (2%)

Query: 194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253
           L AS   P  G+PVTLTC+    L+ SD   +F FFRD + LG GWS SP  QI AMW +
Sbjct: 21  LIASPSHPTEGSPVTLTCKMPF-LQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKE 79

Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQV-QIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312
           D+G YWC+A TM   V+  S RS I V ++P +   L   P      EG ++ L C    
Sbjct: 80  DTGSYWCEAQTMASKVLR-SRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAM 138

Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF---SLTTENSGNYYCTADNGLGAKPSKAV 369
            +    + +Y   V L  +S + +R  +  +   S+   ++  YYC A+NG G  PS  V
Sbjct: 139 GTGDITFLWYKGAVGLNLQS-KTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLV 197

Query: 370 SLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA 429
           S++V +PVS P+L L +P         + LHCEA RGS PILY F+HE   L  RSA S 
Sbjct: 198 SITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSG 257

Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVP 469
           GG + + SLT EHSGNY C A+NG G QRS+AV+L+ TVP
Sbjct: 258 GGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297



 Score =  203 bits (516), Expect = 7e-52
 Identities = 124/270 (45%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 393 EGAKVTLHCEA---QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCT 449
           EG+ VTL C+    Q       + F  +  AL     +S+  + I+ ++  E +G+Y+C 
Sbjct: 30  EGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP-GWSSSPKLQIA-AMWKEDTGSYWCE 87

Query: 450 ADNGFGPQ-RSKAVSLSV-TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF 507
           A        RS+   ++V  VPV+   L          EG  + L C V  G+  I + +
Sbjct: 88  AQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLW 147

Query: 508 YHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565
           Y     + L S +  S+       S+ E  +  YYC A+NG+GP  S +VS+ V +PVSR
Sbjct: 148 YKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSR 207

Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLT 625
           PIL LR PRAQA V D+LELHCEA RGSPPILYWFYHED+TLGS SAPSGG ASFNLSLT
Sbjct: 208 PILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLT 267

Query: 626 AEHSGNYSCEANNGLVAQHSDTISLSVIVP 655
            EHSGNYSCEANNGL AQ S+ ++L+  VP
Sbjct: 268 EEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297



 Score =  198 bits (503), Expect = 2e-50
 Identities = 130/296 (43%), Positives = 168/296 (56%), Gaps = 16/296 (5%)

Query: 464 LSVTVPVSHPV-LTLSSAEALTFEGATVTLHCEV---QRGSPQILYQFYHEDMPL---WS 516
           L +  P+  P  L L ++ +   EG+ VTL C++   Q    Q  + F+ +   L   WS
Sbjct: 7   LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWS 66

Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ-RSEVVSLFV-TVPVSRPILTLRVPR 574
           SS     ++  + ++ +  +G+Y+C A        RS    + V  VPV+   L  + P 
Sbjct: 67  SSP----KLQIA-AMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPG 121

Query: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGG-EASFNL-SLTAEHSGNY 632
            Q + GD L L C    G+  I + +Y   V L   S       A + + S+    +  Y
Sbjct: 122 GQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQY 181

Query: 633 SCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692
            C A NG     S  +S++V +PVSRPIL  RAPRAQA V D+LELHCEALRGS PILYW
Sbjct: 182 YCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYW 241

Query: 693 FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVP 748
           FYHED+TLG  SAPSGGGASFNLSLT EHSG YSCEA+NGL AQRSE VTL   VP
Sbjct: 242 FYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 90/326 (27%), Positives = 140/326 (42%), Gaps = 35/326 (10%)

Query: 90  SPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA----KAEVTLNNTIYKNDNVLA-F 144
           +PL  P  L       ++ +P    EG  V L C+      ++       +++   L   
Sbjct: 11  APLCEPAEL------FLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPG 64

Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV---LRASSFQP 201
            +      I     +D G+Y C     +   + S   +I V       V    +    Q 
Sbjct: 65  WSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQV 124

Query: 202 ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW----SLSPNFQITAMWSKDSGF 257
           + G+ + L C    S+      + F +++    L L      SL+  ++I ++   D+  
Sbjct: 125 MEGDRLVLIC----SVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180

Query: 258 YWCKAAT----MPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQED 313
           Y+C A       P  ++S      I V+IP S P+L L   +A       + LHCE    
Sbjct: 181 YYCVAENGYGPSPSGLVS------ITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRG 234

Query: 314 SLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSV 373
           S   LY FYHE + L  +S     GAS + SLT E+SGNY C A+NGLGA+ S+AV+L+ 
Sbjct: 235 SPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNF 294

Query: 374 TVPVSHPVLNLSSPEDLIFEGAKVTL 399
           TVP      +L+S    + EG   TL
Sbjct: 295 TVPTGARSNHLTSG---VIEGLLSTL 317


>gi|16418419 Fc receptor-like 1 isoform 1 precursor [Homo sapiens]
          Length = 429

 Score =  240 bits (613), Expect = 4e-63
 Identities = 170/420 (40%), Positives = 226/420 (53%), Gaps = 22/420 (5%)

Query: 557 LFVTVPVSRPI-LTLRVPRAQAVVGDLLELHCEAP---RGSPPILYWFYHEDVTLGSSSA 612
           L +  P+  P  L L    +    G  + L C+ P          + F+ +   LG    
Sbjct: 7   LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP--- 63

Query: 613 PSGGEASFNLSLTA---EHSGNYSCEAN---NGLVAQHSDTISLSVIVPVSRPILTFRAP 666
             G  +S  L + A   E +G+Y CEA    + ++      I++   VPV+   L  + P
Sbjct: 64  --GWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHR-VPVADVSLETQPP 120

Query: 667 RAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG-GASFNL-SLTTEHSGI 724
             Q + GD L L C    G+  I + +Y   V L   S       A + + S+    +  
Sbjct: 121 GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180

Query: 725 YSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILY 784
           Y C A+NG     S +V++ V +PVSRP+L LRAP   AAV D+LELHCEALRGSP ILY
Sbjct: 181 YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY 240

Query: 785 RFFHEDVTLGNRSSPSGG-ASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTAN 843
            F+HED+TLG+RS+PSGG AS NLSLT EHSGNYSCEA+NGLGAQRSE VTL  T  T  
Sbjct: 241 WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGA 300

Query: 844 RSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVP 903
           RS    +GV  GLLS  G A  ALL    L RK GR+ A DP RS      QE TY N P
Sbjct: 301 RSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSP 360

Query: 904 AWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDP--RHLRNKGSPIIYSEVKVAS 961
              +LQP+Y N N    + VYS +    + ++ +VA++    H+ +K S  IYS ++ A+
Sbjct: 361 TPGQLQPIYENVNVVSGDEVYS-LAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKAN 419



 Score =  211 bits (538), Expect = 2e-54
 Identities = 122/280 (43%), Positives = 161/280 (57%), Gaps = 7/280 (2%)

Query: 194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253
           L AS   P  G+PVTLTC+    L+ SD   +F FFRD + LG GWS SP  QI AMW +
Sbjct: 21  LIASPSHPTEGSPVTLTCKMPF-LQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKE 79

Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQV-QIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312
           D+G YWC+A TM   V+  S RS I V ++P +   L   P      EG ++ L C    
Sbjct: 80  DTGSYWCEAQTMASKVLR-SRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAM 138

Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF---SLTTENSGNYYCTADNGLGAKPSKAV 369
            +    + +Y   V L  +S + +R  +  +   S+   ++  YYC A+NG G  PS  V
Sbjct: 139 GTGDITFLWYKGAVGLNLQS-KTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLV 197

Query: 370 SLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA 429
           S++V +PVS P+L L +P         + LHCEA RGS PILY F+HE   L  RSA S 
Sbjct: 198 SITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSG 257

Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVP 469
           GG + + SLT EHSGNY C A+NG G QRS+AV+L+ TVP
Sbjct: 258 GGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297



 Score =  203 bits (516), Expect = 7e-52
 Identities = 124/270 (45%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 393 EGAKVTLHCEA---QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCT 449
           EG+ VTL C+    Q       + F  +  AL     +S+  + I+ ++  E +G+Y+C 
Sbjct: 30  EGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP-GWSSSPKLQIA-AMWKEDTGSYWCE 87

Query: 450 ADNGFGPQ-RSKAVSLSV-TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF 507
           A        RS+   ++V  VPV+   L          EG  + L C V  G+  I + +
Sbjct: 88  AQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLW 147

Query: 508 YHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565
           Y     + L S +  S+       S+ E  +  YYC A+NG+GP  S +VS+ V +PVSR
Sbjct: 148 YKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSR 207

Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLT 625
           PIL LR PRAQA V D+LELHCEA RGSPPILYWFYHED+TLGS SAPSGG ASFNLSLT
Sbjct: 208 PILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLT 267

Query: 626 AEHSGNYSCEANNGLVAQHSDTISLSVIVP 655
            EHSGNYSCEANNGL AQ S+ ++L+  VP
Sbjct: 268 EEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297



 Score =  198 bits (503), Expect = 2e-50
 Identities = 130/296 (43%), Positives = 168/296 (56%), Gaps = 16/296 (5%)

Query: 464 LSVTVPVSHPV-LTLSSAEALTFEGATVTLHCEV---QRGSPQILYQFYHEDMPL---WS 516
           L +  P+  P  L L ++ +   EG+ VTL C++   Q    Q  + F+ +   L   WS
Sbjct: 7   LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWS 66

Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ-RSEVVSLFV-TVPVSRPILTLRVPR 574
           SS     ++  + ++ +  +G+Y+C A        RS    + V  VPV+   L  + P 
Sbjct: 67  SSP----KLQIA-AMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPG 121

Query: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGG-EASFNL-SLTAEHSGNY 632
            Q + GD L L C    G+  I + +Y   V L   S       A + + S+    +  Y
Sbjct: 122 GQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQY 181

Query: 633 SCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692
            C A NG     S  +S++V +PVSRPIL  RAPRAQA V D+LELHCEALRGS PILYW
Sbjct: 182 YCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYW 241

Query: 693 FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVP 748
           FYHED+TLG  SAPSGGGASFNLSLT EHSG YSCEA+NGL AQRSE VTL   VP
Sbjct: 242 FYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 90/326 (27%), Positives = 140/326 (42%), Gaps = 35/326 (10%)

Query: 90  SPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA----KAEVTLNNTIYKNDNVLA-F 144
           +PL  P  L       ++ +P    EG  V L C+      ++       +++   L   
Sbjct: 11  APLCEPAEL------FLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPG 64

Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV---LRASSFQP 201
            +      I     +D G+Y C     +   + S   +I V       V    +    Q 
Sbjct: 65  WSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQV 124

Query: 202 ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW----SLSPNFQITAMWSKDSGF 257
           + G+ + L C    S+      + F +++    L L      SL+  ++I ++   D+  
Sbjct: 125 MEGDRLVLIC----SVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180

Query: 258 YWCKAAT----MPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQED 313
           Y+C A       P  ++S      I V+IP S P+L L   +A       + LHCE    
Sbjct: 181 YYCVAENGYGPSPSGLVS------ITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRG 234

Query: 314 SLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSV 373
           S   LY FYHE + L  +S     GAS + SLT E+SGNY C A+NGLGA+ S+AV+L+ 
Sbjct: 235 SPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNF 294

Query: 374 TVPVSHPVLNLSSPEDLIFEGAKVTL 399
           TVP      +L+S    + EG   TL
Sbjct: 295 TVPTGARSNHLTSG---VIEGLLSTL 317


>gi|226958547 Fc receptor-like 1 isoform 2 precursor [Homo sapiens]
          Length = 366

 Score =  207 bits (527), Expect = 4e-53
 Identities = 120/278 (43%), Positives = 159/278 (57%), Gaps = 7/278 (2%)

Query: 194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253
           L AS   P  G+PVTLTC+    L+ SD   +F FFRD + LG GWS SP  QI AMW +
Sbjct: 21  LIASPSHPTEGSPVTLTCKMPF-LQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKE 79

Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQV-QIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312
           D+G YWC+A TM   V+  S RS I V ++P +   L   P      EG ++ L C    
Sbjct: 80  DTGSYWCEAQTMASKVLR-SRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAM 138

Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF---SLTTENSGNYYCTADNGLGAKPSKAV 369
            +    + +Y   V L  +S + +R  +  +   S+   ++  YYC A+NG G  PS  V
Sbjct: 139 GTGDITFLWYKGAVGLNLQS-KTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLV 197

Query: 370 SLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA 429
           S++V +PVS P+L L +P         + LHCEA RGS PILY F+HE   L  RSA S 
Sbjct: 198 SITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSG 257

Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVT 467
           GG + + SLT EHSGNY C A+NG G QRS+AV+L+ T
Sbjct: 258 GGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFT 295



 Score =  199 bits (507), Expect = 8e-51
 Identities = 122/266 (45%), Positives = 159/266 (59%), Gaps = 9/266 (3%)

Query: 393 EGAKVTLHCEA---QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCT 449
           EG+ VTL C+    Q       + F  +  AL     +S+  + I+ ++  E +G+Y+C 
Sbjct: 30  EGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP-GWSSSPKLQIA-AMWKEDTGSYWCE 87

Query: 450 ADNGFGPQ-RSKAVSLSV-TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF 507
           A        RS+   ++V  VPV+   L          EG  + L C V  G+  I + +
Sbjct: 88  AQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLW 147

Query: 508 YHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565
           Y     + L S +  S+       S+ E  +  YYC A+NG+GP  S +VS+ V +PVSR
Sbjct: 148 YKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSR 207

Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLT 625
           PIL LR PRAQA V D+LELHCEA RGSPPILYWFYHED+TLGS SAPSGG ASFNLSLT
Sbjct: 208 PILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLT 267

Query: 626 AEHSGNYSCEANNGLVAQHSDTISLS 651
            EHSGNYSCEANNGL AQ S+ ++L+
Sbjct: 268 EEHSGNYSCEANNGLGAQRSEAVTLN 293



 Score =  194 bits (493), Expect = 3e-49
 Identities = 128/291 (43%), Positives = 166/291 (57%), Gaps = 16/291 (5%)

Query: 464 LSVTVPVSHPV-LTLSSAEALTFEGATVTLHCEV---QRGSPQILYQFYHEDMPL---WS 516
           L +  P+  P  L L ++ +   EG+ VTL C++   Q    Q  + F+ +   L   WS
Sbjct: 7   LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWS 66

Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ-RSEVVSLFV-TVPVSRPILTLRVPR 574
           SS     ++  + ++ +  +G+Y+C A        RS    + V  VPV+   L  + P 
Sbjct: 67  SSP----KLQIA-AMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPG 121

Query: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGG-EASFNL-SLTAEHSGNY 632
            Q + GD L L C    G+  I + +Y   V L   S       A + + S+    +  Y
Sbjct: 122 GQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQY 181

Query: 633 SCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692
            C A NG     S  +S++V +PVSRPIL  RAPRAQA V D+LELHCEALRGS PILYW
Sbjct: 182 YCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYW 241

Query: 693 FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTL 743
           FYHED+TLG  SAPSGGGASFNLSLT EHSG YSCEA+NGL AQRSE VTL
Sbjct: 242 FYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTL 292



 Score =  191 bits (486), Expect = 2e-48
 Identities = 143/379 (37%), Positives = 187/379 (49%), Gaps = 59/379 (15%)

Query: 557 LFVTVPVSRPI-LTLRVPRAQAVVGDLLELHCEAP---RGSPPILYWFYHEDVTLGSSSA 612
           L +  P+  P  L L    +    G  + L C+ P          + F+ +   LG    
Sbjct: 7   LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP--- 63

Query: 613 PSGGEASFNLSLTA---EHSGNYSCEAN---NGLVAQHSDTISLSVIVPVSRPILTFRAP 666
             G  +S  L + A   E +G+Y CEA    + ++      I++   VPV+   L  + P
Sbjct: 64  --GWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHR-VPVADVSLETQPP 120

Query: 667 RAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG-GASFNL-SLTTEHSGI 724
             Q + GD L L C    G+  I + +Y   V L   S       A + + S+    +  
Sbjct: 121 GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180

Query: 725 YSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILY 784
           Y C A+NG     S +V++ V +PVSRP+L LRAP   AAV D+LELHCEALRGSP ILY
Sbjct: 181 YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY 240

Query: 785 RFFHEDVTLGNRSSPS-GGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTAN 843
            F+HED+TLG+RS+PS GGAS NLSLT EHSGNYSCEA+NGLGAQRSE VTL  T     
Sbjct: 241 WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFT----- 295

Query: 844 RSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVP 903
                                             GR+ A DP RS      QE TY N P
Sbjct: 296 ----------------------------------GRRSARDPLRSLPSPLPQEFTYLNSP 321

Query: 904 AWEELQPVYTNANPRGENV 922
              +LQP+Y N  PR ++V
Sbjct: 322 TPGQLQPIYEN-EPREQSV 339



 Score =  148 bits (373), Expect = 3e-35
 Identities = 105/306 (34%), Positives = 149/306 (48%), Gaps = 32/306 (10%)

Query: 274 PRSWIQVQIPASHPV-LTLSPEKALNFEGTKVTLHCET---QEDSLRTLYRFYHEGVPLR 329
           PR  + +  P   P  L L    +   EG+ VTL C+    Q    +  + F+ +   L 
Sbjct: 3   PRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALG 62

Query: 330 ---HKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTV---PVSHPVLN 383
                S + +  A     +  E++G+Y+C A   + +K  ++    + V   PV+   L 
Sbjct: 63  PGWSSSPKLQIAA-----MWKEDTGSYWCEAQT-MASKVLRSRRSQINVHRVPVADVSLE 116

Query: 384 LSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEH- 442
              P   + EG ++ L C    G+  I + ++     L  +S           SLTAE+ 
Sbjct: 117 TQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQR-------SLTAEYE 169

Query: 443 --------SGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHC 494
                   +  YYC A+NG+GP  S  VS++V +PVS P+L L +  A       + LHC
Sbjct: 170 IPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHC 229

Query: 495 EVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV 554
           E  RGSP ILY FYHED+ L S S PS G  SF+ SLTE HSGNY C A+NG G QRSE 
Sbjct: 230 EALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEA 289

Query: 555 VSLFVT 560
           V+L  T
Sbjct: 290 VTLNFT 295


>gi|50878302 Fc receptor-like B [Homo sapiens]
          Length = 426

 Score =  166 bits (419), Expect = 1e-40
 Identities = 108/301 (35%), Positives = 158/301 (52%), Gaps = 21/301 (6%)

Query: 7   LLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFR----FYSPQKTKWYHRYL 62
           LL+L P SGQ A   +PI+ L PPWTT+F+GERVTL C G+        P  T W   YL
Sbjct: 7   LLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLW---YL 63

Query: 63  GKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS-VFEGDSVVL 121
           G  +L  +    +EVQ  G YRCQ +G+P+S P+HL  S+  LILQ P + VFEG+ +VL
Sbjct: 64  G-HLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVL 122

Query: 122 RCRAKAEVTLNNTIYKND-NVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE---SCCPVS 177
           RCR   +  +    Y +D   + + +   ++ +  A   D+G Y+C+G         P+ 
Sbjct: 123 RCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAPMF 182

Query: 178 SNTVKIQVQEPFTRPVLRASSFQPISG---NPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
           S  V + VQE F  PVLR    +   G     V L C+T+L  ++ D PL+F F++  + 
Sbjct: 183 SAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRA 242

Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPAS--HPVLTLS 292
           +   +     + +     ++   YWC+AAT   SV   SP  W+Q+  P S   P  T +
Sbjct: 243 V-RRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSP--WLQLPGPGSPLDPASTTA 299

Query: 293 P 293
           P
Sbjct: 300 P 300



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 59/237 (24%), Positives = 90/237 (37%), Gaps = 37/237 (15%)

Query: 287 PVLTLSPEKALNFEGTKVTLHCE------TQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340
           P+L+L P     F+G +VTL C+       +   + TL+   H  +P   KS+       
Sbjct: 23  PILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKKSIE------ 76

Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400
                  +  G Y C      GA  S  + LSV    S+  L L  P   +FEG  + L 
Sbjct: 77  ------VQTPGVYRCQTR---GAPVSDPIHLSV----SNDWLILQVPYAPVFEGEPLVLR 123

Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460
           C      +     ++H+G A+  R  +S+    +     A  SG Y C+       + + 
Sbjct: 124 CRGWYDKVVYKLHYYHDGQAV--RYFHSSANYTV-LQARASDSGRYQCSGTMRIPVESAP 180

Query: 461 AVSLSVTVPVSH----PVL-TLSSAEALTFEGATVTLHCEV----QRGSPQILYQFY 508
             S  V V V      PVL  +   EA       V L C+     Q+    + + FY
Sbjct: 181 MFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFY 237



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 77/320 (24%), Positives = 115/320 (35%), Gaps = 56/320 (17%)

Query: 563 VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY--------WFYHEDVTLGSSSAPS 614
           + +PIL+L  P      G+ + L C+   G  P+L         W+      LG    PS
Sbjct: 20  LEKPILSLHPPWTTIFKGERVTLKCD---GYHPLLLELQPISTLWY------LGHLLLPS 70

Query: 615 GGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD 674
             +     S+  +  G Y C+     V   SD I LSV    S   L  + P A    G+
Sbjct: 71  HKK-----SIEVQTPGVYRCQTRGAPV---SDPIHLSV----SNDWLILQVPYAPVFEGE 118

Query: 675 LLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFN-LSLTTEHSGIYSCEADNGL 733
            L L C            +YH+    G+        A++  L      SG Y C     +
Sbjct: 119 PLVLRCRGWYDKVVYKLHYYHD----GQAVRYFHSSANYTVLQARASDSGRYQCSGTMRI 174

Query: 734 EAQRSEMVTLKVAVPVSR----PVLTLRAP--GTHAAVGDLLELHCEA-----LRGSPLI 782
             + + M + KVAV V      PVL +  P     AA+G ++ L C+       R +PL 
Sbjct: 175 PVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVV-LRCDTRLHPQKRDTPL- 232

Query: 783 LYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITG--- 839
             +F     +   R    G          E   +Y CEA     + R  +  L + G   
Sbjct: 233 --QFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGS 290

Query: 840 ----LTANRSGPFATGVAGG 855
                +     P+A  +A G
Sbjct: 291 PLDPASTTAPAPWAAALAPG 310



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 55/235 (23%), Positives = 88/235 (37%), Gaps = 41/235 (17%)

Query: 204 GNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAA 263
           G  VTL C+    L     P+   ++       LG  L P+ +  ++  +  G Y C+  
Sbjct: 37  GERVTLKCDGYHPLLLELQPISTLWY-------LGHLLLPSHK-KSIEVQTPGVYRCQTR 88

Query: 264 TMPYS--VISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRF 321
             P S  +       W+ +Q+P + PV          FEG  + L C    D +     +
Sbjct: 89  GAPVSDPIHLSVSNDWLILQVPYA-PV----------FEGEPLVLRCRGWYDKVVYKLHY 137

Query: 322 YHEGVPLR--HKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH 379
           YH+G  +R  H S                +SG Y C+    +  + +   S  V V V  
Sbjct: 138 YHDGQAVRYFHSSAN-----YTVLQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQE 192

Query: 380 ----PVLNLSSPEDLIFEGAK---VTLHCEA----QRGSLPILYQFHHEGAALER 423
               PVL +  P +    GA    V L C+     Q+   P+ + F+    A+ R
Sbjct: 193 LFRAPVLRVMGPREA--RGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRR 245



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 58/241 (24%), Positives = 91/241 (37%), Gaps = 45/241 (18%)

Query: 380 PVLNLSSPEDLIFEGAKVTLHCEAQRGSL----PI--LYQFHHEGAALERRSANSAGGVA 433
           P+L+L  P   IF+G +VTL C+     L    PI  L+   H      ++         
Sbjct: 23  PILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKK--------- 73

Query: 434 ISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLH 493
              S+  +  G Y C         R   VS  + + VS+  L L    A  FEG  + L 
Sbjct: 74  ---SIEVQTPGVYRCQT-------RGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVLR 123

Query: 494 CEVQRGSPQILYQFYHEDMPL---WSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ 550
           C            +YH+   +    SS+  +V +   S       SG Y C+       +
Sbjct: 124 CRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARAS------DSGRYQCSGTMRIPVE 177

Query: 551 RSEVVSLFVTVPVSR----PILTLRVPRAQ--AVVGDLLELHCEA----PRGSPPILYWF 600
            + + S  V V V      P+L +  PR    A +G ++ L C+      +   P+ + F
Sbjct: 178 SAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVV-LRCDTRLHPQKRDTPLQFAF 236

Query: 601 Y 601
           Y
Sbjct: 237 Y 237


>gi|10835133 Fc fragment of IgG, high affinity Ia, receptor (CD64)
           [Homo sapiens]
          Length = 374

 Score =  157 bits (397), Expect = 5e-38
 Identities = 105/286 (36%), Positives = 147/286 (51%), Gaps = 14/286 (4%)

Query: 3   LWVI--LLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           +W +  LL+  PV GQ   T + +I LQPPW +VFQ E VTL C+         T+W+  
Sbjct: 1   MWFLTTLLLWVPVDGQ-VDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLN 59

Query: 61  YLGKEILRETPD---NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF-EG 116
             G      TP        V +SGEYRCQ   S  S P+ L+     L+LQ    VF EG
Sbjct: 60  --GTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEG 117

Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175
           + + LRC A K ++  N   Y+N     F +  ++  I    +  NG Y C+G  +    
Sbjct: 118 EPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKH--R 175

Query: 176 VSSNTVKIQVQEPFTRPVLRASSFQP-ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
            +S  + + V+E F  PVL AS   P + GN VTL+CET+L L+R  + L F F+   +T
Sbjct: 176 YTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKT 235

Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQV 280
           L  G + S  +QI     +DSG YWC+AAT   +V+  SP   +QV
Sbjct: 236 L-RGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQV 280



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 69/274 (25%), Positives = 109/274 (39%), Gaps = 28/274 (10%)

Query: 277 WIQV--QIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVR 334
           W+ V  Q+  +  V+TL P     F+   VTLHCE       +  +++  G      + +
Sbjct: 10  WVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGT-----ATQ 64

Query: 335 CERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEG 394
               +    S +  +SG Y C    GL  +     S  + + +    L L     +  EG
Sbjct: 65  TSTPSYRITSASVNDSGEYRC--QRGLSGR-----SDPIQLEIHRGWLLLQVSSRVFTEG 117

Query: 395 AKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGF 454
             + L C A +  L     ++  G A +    NS   +         H+G Y+C   +G 
Sbjct: 118 EPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTI---LKTNISHNGTYHC---SGM 171

Query: 455 GPQRSKAVSLSVTVPVSHPVLTL-SSAEALTFEGATVTLHCE----VQRGSPQILYQFYH 509
           G  R  +  +SVTV    P   L +S  +   EG  VTL CE    +QR   Q+ + FY 
Sbjct: 172 GKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYM 231

Query: 510 EDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTA 543
               L   +T S  ++    +     SG Y+C A
Sbjct: 232 GSKTLRGRNTSSEYQI---LTARREDSGLYWCEA 262



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 85/326 (26%), Positives = 124/326 (38%), Gaps = 57/326 (17%)

Query: 468 VPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSF 527
           V  +  V+TL       F+  TVTLHCEV         Q++        +STPS    S 
Sbjct: 17  VDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTAT-QTSTPSYRITSA 75

Query: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587
           S +     SG Y C    G    RS+ + L     + R  L L+V       G+ L L C
Sbjct: 76  SVN----DSGEYRC--QRGLS-GRSDPIQL----EIHRGWLLLQVSSRVFTEGEPLALRC 124

Query: 588 EAPRGS--PPILYW-------FYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANN 638
            A +      +LY+       F+H +  L              L     H+G Y C   +
Sbjct: 125 HAWKDKLVYNVLYYRNGKAFKFFHWNSNLTI------------LKTNISHNGTYHC---S 169

Query: 639 GLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVV-GDLLELHCEA----LRGSSPILYWF 693
           G+      +  +SV V    P     A     ++ G+L+ L CE      R    + + F
Sbjct: 170 GMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSF 229

Query: 694 YHEDVTLGKISAPSGGGASFNLSLTT---EHSGIYSCEA--DNGLEAQRS-----EMVTL 743
           Y    TL       G   S    + T   E SG+Y CEA  ++G   +RS     +++ L
Sbjct: 230 YMGSKTL------RGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGL 283

Query: 744 KVAVPVSRPVLTLRAPGTHAAVGDLL 769
           ++  PV   VL   A G    V  +L
Sbjct: 284 QLPTPVWFHVLFYLAVGIMFLVNTVL 309


>gi|157057547 Fc receptor-like 6 [Homo sapiens]
          Length = 434

 Score =  133 bits (335), Expect = 7e-31
 Identities = 129/408 (31%), Positives = 187/408 (45%), Gaps = 45/408 (11%)

Query: 580 GDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNG 639
           GD L L C+  + +P     FY +   L  S      +     + T +  G YSC     
Sbjct: 32  GDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKE---NQTLSMGAATVQSRGQYSCSGQVM 88

Query: 640 LVAQHSDTISLSVIVPVSR----PILTFRAPRAQAVVGDLLELHCEA----LRGSSPILY 691
            + Q     S + +V V      P+L+   P  +   G L+ L C+     LR +  +L+
Sbjct: 89  YIPQTFTQTSETAMVQVQELFPPPVLS-AIPSPEPREGSLVTLRCQTKLHPLRSALRLLF 147

Query: 692 WFYHEDVTLGKISAPSGGGASFNLSLTTE-HSGIYSCEA--DNGLEAQRSEMVTLKVAVP 748
            F+ +  TL       G      +    E  SG+Y CE   + G   ++S  + ++V  P
Sbjct: 148 SFHKDGHTL----QDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAP 203

Query: 749 VSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGG-ASLNL 807
           VSRPVLTL       AVGD+++L CEA RGSP ILY F+ ++  +GN S+P GG  SL  
Sbjct: 204 VSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLF 263

Query: 808 SLTAEH-SGNYSCEADNGLGAQRSETVTLYITG---LTANRSGPFATGVAGGLLSIAGLA 863
            + +E  +GNYSCEA+N +  +RSE   L + G   L    S      +   LL +  +A
Sbjct: 264 PVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIA 323

Query: 864 AGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVV 923
           A ALL+Y    RKAG  P+  P  +P     Q P Y NV           +   + E VV
Sbjct: 324 A-ALLVYVRSWRKAGPLPSQIPPTAP--GGEQCPLYANV----------HHQKGKDEGVV 370

Query: 924 YSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVK------VASTPVS 965
           YS V   +  K+    S    +  K S II +EV+      V+ST V+
Sbjct: 371 YSVVH--RTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVN 416



 Score =  131 bits (330), Expect = 3e-30
 Identities = 98/276 (35%), Positives = 134/276 (48%), Gaps = 8/276 (2%)

Query: 105 LILQA-PLSVFEGDSVVLRCRAKAEVTLNNT-IYKNDNVLAFLNKRTDFHIPHACLKDNG 162
           L LQA P  VFEGD++ LRC+      L+    Y++   L F  +     +  A ++  G
Sbjct: 20  LYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRG 79

Query: 163 AYRCTG---YKESCCPVSSNTVKIQVQEPFTRPVLRA-SSFQPISGNPVTLTCETQLSLE 218
            Y C+G   Y       +S T  +QVQE F  PVL A  S +P  G+ VTL C+T+L   
Sbjct: 80  QYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPL 139

Query: 219 RSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWI 278
           RS + L F F +D  TL       P   I      DSG YWC+ A     V   SP+  +
Sbjct: 140 RSALRLLFSFHKDGHTLQ-DRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEV 198

Query: 279 QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERG 338
           +VQ P S PVLTL    A    G  V L CE Q  S   LY FY +   + + S  C   
Sbjct: 199 RVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGT 258

Query: 339 ASISFSLTTE-NSGNYYCTADNGLGAKPSKAVSLSV 373
            S+ F + +E ++GNY C A+N +  + S+   LS+
Sbjct: 259 TSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSL 294



 Score =  120 bits (301), Expect = 6e-27
 Identities = 88/274 (32%), Positives = 135/274 (49%), Gaps = 20/274 (7%)

Query: 391 IFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTA 450
           +FEG  +TL C+  + +     +F+ +G  L     N    +  +   T +  G Y C+ 
Sbjct: 29  VFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAA---TVQSRGQYSCSG 85

Query: 451 DNGFGPQRSKAVSLSVTVPVSH----PVLT-LSSAEALTFEGATVTLHCEVQ----RGSP 501
              + PQ     S +  V V      PVL+ + S E    EG+ VTL C+ +    R + 
Sbjct: 86  QVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPR--EGSLVTLRCQTKLHPLRSAL 143

Query: 502 QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTA--DNGFGPQRSEVVSLFV 559
           ++L+ F+ +   L          +       EG SG Y+C    + G   ++S  + + V
Sbjct: 144 RLLFSFHKDGHTLQDRGPHPELCIP---GAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRV 200

Query: 560 TVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEAS 619
             PVSRP+LTL    A   VGD+++L CEA RGSPPILY FY ++  +G+ SAP GG  S
Sbjct: 201 QAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTS 260

Query: 620 FNLSLTAEH-SGNYSCEANNGLVAQHSDTISLSV 652
               + +E  +GNYSCEA N +  + S+   LS+
Sbjct: 261 LLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSL 294



 Score = 97.1 bits (240), Expect = 7e-20
 Identities = 86/280 (30%), Positives = 125/280 (44%), Gaps = 34/280 (12%)

Query: 204 GNPVTLTCETQLSLERSDVPLR-----FRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFY 258
           G+ +TL C+   +   S V          F +++QTL +G          A   +  G Y
Sbjct: 32  GDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMG----------AATVQSRGQY 81

Query: 259 WCKAATM--PYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQ----E 312
            C    M  P +    S  + +QVQ     PVL+  P      EG+ VTL C+T+     
Sbjct: 82  SCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPR-EGSLVTLRCQTKLHPLR 140

Query: 313 DSLRTLYRFYHEGVPLRHKSVR---CERGASISFSLTTENSGNYYCTA--DNGLGAKPSK 367
            +LR L+ F+ +G  L+ +      C  GA         +SG Y+C    + G   K S 
Sbjct: 141 SALRLLFSFHKDGHTLQDRGPHPELCIPGAKEG------DSGLYWCEVAPEGGQVQKQSP 194

Query: 368 AVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSAN 427
            + + V  PVS PVL L         G  V L CEAQRGS PILY F+ +   +   SA 
Sbjct: 195 QLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAP 254

Query: 428 SAGGVAISFSLTAEH-SGNYYCTADNGFGPQRSKAVSLSV 466
             G  ++ F + +E  +GNY C A+N    +RS+   LS+
Sbjct: 255 CGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSL 294



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 78/293 (26%), Positives = 126/293 (43%), Gaps = 46/293 (15%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  +L+  P  G+        ++LQ     VF+G+ +TL C+G++     + K+Y  
Sbjct: 1   MLLWTAVLLFVPCVGKTVW-----LYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRD 55

Query: 61  YLGKEILRETPDNILE-----VQESGEYRCQAQGSPLSSPVHLDFSSASLILQA----PL 111
             GK +     +  L      VQ  G+Y C   G  +  P     +S + ++Q     P 
Sbjct: 56  --GKFLHFSKENQTLSMGAATVQSRGQYSC--SGQVMYIPQTFTQTSETAMVQVQELFPP 111

Query: 112 SVF---------EGDSVVLRCRAK-----AEVTLNNTIYKNDNVLAFLNKRTDFHIPHAC 157
            V          EG  V LRC+ K     + + L  + +K+ + L       +  IP A 
Sbjct: 112 PVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAK 171

Query: 158 LKDNGAYRCTGYKE-SCCPVSSNTVKIQVQEPFTRPV--LRASSFQPISGNPVTLTCETQ 214
             D+G Y C    E       S  ++++VQ P +RPV  L      P  G+ V L CE Q
Sbjct: 172 EGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQ 231

Query: 215 LSLERSDVPLRFRFFRDDQTLG-----LGWSLSPNFQITAMWSKDSGFYWCKA 262
               R   P+ + F+ D++ +G      G + S  F + +   +D+G Y C+A
Sbjct: 232 ----RGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKS--EQDAGNYSCEA 278


>gi|69885149 Fc receptor-like and mucin-like 1 [Homo sapiens]
          Length = 376

 Score =  124 bits (310), Expect = 6e-28
 Identities = 88/236 (37%), Positives = 127/236 (53%), Gaps = 13/236 (5%)

Query: 70  TPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS-VFEGDSVVLRCRAKAE 128
           T D++ + +E+G    Q +    S P HL  S   LILQ P   VFEGD +VLRC+A  +
Sbjct: 65  TEDDLTDAREAG---FQVKAYTFSEPFHLIVSYDWLILQGPAKPVFEGDLLVLRCQAWQD 121

Query: 129 VTLNN-TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESC---CPVSSNTVKIQ 184
             L   T Y++ + L       +F I      D+G Y C+G  +S     P +++ V I 
Sbjct: 122 WPLTQVTFYRDGSALGPPGPNREFSITVVQKADSGHYHCSGIFQSPGPGIPETASVVAIT 181

Query: 185 VQEPFTRPVLRA-SSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSP 243
           VQE F  P+LRA  S +P +G+P+TL+C+T+L L+RS   L F F++D + +     LS 
Sbjct: 182 VQELFPAPILRAVPSAEPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIV-QSRGLSS 240

Query: 244 NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ---IPASHPVLTLSPEKA 296
            FQI       SG YWC+AAT    V   SP+  I+VQ     A+ P L  +P+K+
Sbjct: 241 EFQIPTASEDHSGSYWCEAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKS 296



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 63/232 (27%), Positives = 103/232 (44%), Gaps = 24/232 (10%)

Query: 377 VSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISF 436
           VS+  L L  P   +FEG  + L C+A +        F+ +G+AL     N    + +  
Sbjct: 92  VSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALGPPGPNREFSITV-- 149

Query: 437 SLTAEHSGNYYCTA---DNGFG-PQRSKAVSLSVTVPVSHPVL-TLSSAEALTFEGATVT 491
            +    SG+Y+C+      G G P+ +  V+++V      P+L  + SAE     G+ +T
Sbjct: 150 -VQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQA--GSPMT 206

Query: 492 LHCE----VQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYC---TAD 544
           L C+    +QR + ++L+ FY +   + S    S  ++    + +E HSG+Y+C   T D
Sbjct: 207 LSCQTKLPLQRSAARLLFSFYKDGRIVQSRGLSSEFQIP---TASEDHSGSYWCEAATED 263

Query: 545 NGFGPQRSEVVSLFVTVPVSRPILTLR-VPRAQAVVGDLLELHCEAPRGSPP 595
           N    Q  ++         S    TL   P+  A  G   E   EAP   PP
Sbjct: 264 NQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPGTAPE---EAPGPLPP 312



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 59/218 (27%), Positives = 98/218 (44%), Gaps = 23/218 (10%)

Query: 563 VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL 622
           VS   L L+ P      GDLL L C+A +  P     FY +    GS+  P G    F++
Sbjct: 92  VSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRD----GSALGPPGPNREFSI 147

Query: 623 SLTAE-HSGNYSC----EANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLE 677
           ++  +  SG+Y C    ++    + + +  ++++V      PIL    P A+   G  + 
Sbjct: 148 TVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILR-AVPSAEPQAGSPMT 206

Query: 678 LHCEA----LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE-HSGIYSCEA--- 729
           L C+      R ++ +L+ FY +    G+I    G  + F +   +E HSG Y CEA   
Sbjct: 207 LSCQTKLPLQRSAARLLFSFYKD----GRIVQSRGLSSEFQIPTASEDHSGSYWCEAATE 262

Query: 730 DNGLEAQRSEM-VTLKVAVPVSRPVLTLRAPGTHAAVG 766
           DN +  Q  ++ + ++ A   + P     AP   AA G
Sbjct: 263 DNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPG 300



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 63/232 (27%), Positives = 99/232 (42%), Gaps = 41/232 (17%)

Query: 277 WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCE 336
           W+ +Q PA  PV          FEG  + L C+  +D   T   FY +G      S    
Sbjct: 96  WLILQGPAK-PV----------FEGDLLVLRCQAWQDWPLTQVTFYRDG------SALGP 138

Query: 337 RGASISFSLTT---ENSGNYYCTA---DNGLGAKPSKAVSLSVTVPVSHPVLNLSS-PED 389
            G +  FS+T     +SG+Y+C+      G G  P  A  +++TV    P   L + P  
Sbjct: 139 PGPNREFSITVVQKADSGHYHCSGIFQSPGPGI-PETASVVAITVQELFPAPILRAVPSA 197

Query: 390 LIFEGAKVTLHCEA----QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGN 445
               G+ +TL C+     QR +  +L+ F+ +G  ++ R  +S   +    + + +HSG+
Sbjct: 198 EPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIVQSRGLSSEFQIP---TASEDHSGS 254

Query: 446 YYC---TADNGFGPQ------RSKAVSLSVTVPVSHPVLTLSSAEALTFEGA 488
           Y+C   T DN    Q      R +  S S   P  +P    S+A     E A
Sbjct: 255 YWCEAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPGTAPEEA 306



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 53/206 (25%), Positives = 82/206 (39%), Gaps = 24/206 (11%)

Query: 656 VSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNL 715
           VS   L  + P      GDLL L C+A +        FY +   LG    P G    F++
Sbjct: 92  VSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALG----PPGPNREFSI 147

Query: 716 SLTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSR--PVLTLRA-PGTHAAVGDLLEL 771
           ++  +  SG Y C                 VA+ V    P   LRA P      G  + L
Sbjct: 148 TVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQAGSPMTL 207

Query: 772 HCEAL----RGSPLILYRFFHEDVTLGNRSSPSGGASLNLSL---TAEHSGNYSCEA--- 821
            C+      R +  +L+ F+ +      R   S G S    +   + +HSG+Y CEA   
Sbjct: 208 SCQTKLPLQRSAARLLFSFYKD-----GRIVQSRGLSSEFQIPTASEDHSGSYWCEAATE 262

Query: 822 DNGLGAQRSETVTLYITGLTANRSGP 847
           DN +  Q S  + + + G +++ + P
Sbjct: 263 DNQVWKQ-SPQLEIRVQGASSSAAPP 287



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 36/166 (21%), Positives = 67/166 (40%), Gaps = 19/166 (11%)

Query: 25  IFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKE-ILRETPDNILEVQESG 81
           + LQ P   VF+G+ + L C+ ++ +   +  +Y     LG     RE    +++  +SG
Sbjct: 97  LILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALGPPGPNREFSITVVQKADSG 156

Query: 82  EYRC----QAQGSPLSSPVHLDFSSASLILQAPL-------SVFEGDSVVLRCRAK---- 126
            Y C    Q+ G  +     +   +   +  AP+           G  + L C+ K    
Sbjct: 157 HYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQAGSPMTLSCQTKLPLQ 216

Query: 127 -AEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171
            +   L  + YK+  ++      ++F IP A    +G+Y C    E
Sbjct: 217 RSAARLLFSFYKDGRIVQSRGLSSEFQIPTASEDHSGSYWCEAATE 262


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  113 bits (282), Expect = 1e-24
 Identities = 192/811 (23%), Positives = 304/811 (37%), Gaps = 100/811 (12%)

Query: 76   EVQESGEYRCQAQ--GSPLSSPVHLDFSSASLILQ--APLSVFEGDSVVLRCRAKAEVTL 131
            E   +G+Y CQ +  G    +   L     ++I++   P++V  G++  L C+      L
Sbjct: 5674 EPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPEL 5733

Query: 132  NNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRC---TGYKESCCPVSSNT 180
            +   YK+  +L        +F NK +   I     +D G Y         +S C    + 
Sbjct: 5734 SVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDV 5793

Query: 181  VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240
                V   FTR   R  +   + G    L C+   S      P+   +F +   +  G  
Sbjct: 5794 SDRAVPPSFTR---RLKNTGGVLGASCILECKVAGSS-----PISVAWFHEKTKIVSGAK 5845

Query: 241  LSPNF-------QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293
                F       Q+ ++ S D G Y C AA +  S   D  R+ + VQ P   P     P
Sbjct: 5846 YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGS---DECRAVLTVQEP---PSFVKEP 5899

Query: 294  EKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRC-----ERGASIS-FSLTT 347
            E      G  VT     +      +  F   G     K  RC     +  A +  F++  
Sbjct: 5900 EPLEVLPGKNVTFTSVIRGTPPFKVNWF--RGARELVKGDRCNIYFEDTVAELELFNIDI 5957

Query: 348  ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
              SG Y C   N  G       S +  + V  P   L    D   E  K  +      G+
Sbjct: 5958 SQSGEYTCVVSNNAGQ-----ASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGT 6012

Query: 408  LPILYQFHHEGAAL---ERRSANSAGGVAISFSL--TAEHSGNYYCTADNGFGPQRSKAV 462
            LPI   +  +G  +   E+ +  +     I   L  T   +G Y C  +N  G  R    
Sbjct: 6013 LPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG--RDVCG 6070

Query: 463  SLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS---- 518
            +L  T+   + V  L   EA    G +V+L C+V  G+P+I   +Y  D  L  +     
Sbjct: 6071 ALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVA-GTPEITVSWYKGDTKLRPTPEYRT 6127

Query: 519  --TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQ 576
              T +V  + F+  +    SG Y C A+N  G   S+ V       +  P    ++   +
Sbjct: 6128 YFTNNVATLVFN-KVNINDSGEYTCKAENSIGTASSKTVFRIQERQLP-PSFARQLKDIE 6185

Query: 577  AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGS-----SSAPSGGEASFNLSLTAEHSGN 631
              VG  + L C    GS PI   +Y + V L       +S          L     HSG 
Sbjct: 6186 QTVGLPVTLTCRL-NGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQ 6244

Query: 632  YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILY 691
            YSC A+N L    S +  L+   P   P    +      + G+  +  C  + G+ P+  
Sbjct: 6245 YSCSASNPL-GTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECH-VTGAQPMRI 6302

Query: 692  WFYHEDVTLGKISAPSGGGASFNLSLTTEH----------SGIYSCEADNGLEAQRSEMV 741
             +  ++  +       GG  +      T H          SG Y+C+A N +     +M 
Sbjct: 6303 TWSKDNKEIRP-----GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVG---KDMC 6354

Query: 742  TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLG-----NR 796
            + +++V      +        A  G+ ++L C+ + GSP I   +F  D  L      N 
Sbjct: 6355 SAQLSVKEPPKFVKKLEASKVAKQGESIQLECK-ISGSPEIKVSWFRNDSELHESWKYNM 6413

Query: 797  SSPSGGASLNLS-LTAEHSGNYSCEADNGLG 826
            S  +  A L ++  +AE SG+Y CEA NG+G
Sbjct: 6414 SFINSVALLTINEASAEDSGDYICEAHNGVG 6444



 Score =  112 bits (280), Expect = 2e-24
 Identities = 201/827 (24%), Positives = 308/827 (37%), Gaps = 117/827 (14%)

Query: 75   LEVQESGEYRCQAQGSPLSSPVHLDFSSASLIL---------QAPLSVFEGDSVVLRCRA 125
            L +Q+ G Y C+A     S+    D   A LI+           P+       V L C+ 
Sbjct: 3613 LTIQDRGVYSCKA-----SNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQV 3667

Query: 126  KAEVTLNNTIYKN--------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVS 177
              +  +  T  K+        D  + F +K     IP A LKD+G Y CT   E+     
Sbjct: 3668 DEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSC 3727

Query: 178  SNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGL 237
            S TV ++    F + V    S+  + G    L C+    L+ S V ++  +F++++ L  
Sbjct: 3728 SATVTVREPPSFVKKV--DPSYLMLPGESARLHCK----LKGSPV-IQVTWFKNNKELSE 3780

Query: 238  GWSLSPNF-------QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290
              ++   F        IT +  +DSG Y C+A      V SDS  + I ++ P S  + T
Sbjct: 3781 SNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVN---DVGSDSCSTEIVIKEPPSF-IKT 3836

Query: 291  LSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASI----SFSLT 346
            L P   +   GT   L CE        +  F  +      K  R     S+     FS  
Sbjct: 3837 LEPADIV--RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFN 3894

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406
            + + G Y C   N +G     A  L     +  P   +   +DLI  G +      A RG
Sbjct: 3895 SADVGEYECVVANEVGKCGCMATHL-----LKEPPTFVKKVDDLIALGGQTVTLQAAVRG 3949

Query: 407  SLPILYQFHHEGAALE-----RRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKA 461
            S PI   +      +      + S ++   V I   +     G Y C A+N  G Q S  
Sbjct: 3950 SEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVG 4009

Query: 462  VSLSVTVPVSHPVLTLSSAEAL-TFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTP 520
              +     V  P   +  AE +    G   TL   V  G+P++  ++Y +  PL +S   
Sbjct: 4010 ELI-----VKEPAKIIERAELIQVTAGDPATLEYTV-AGTPELKPKWYKDGRPLVASKK- 4062

Query: 521  SVGRVSF-------SFSLTEGH-SGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572
               R+SF        F   E H SG Y     N  G    E     +   ++ P  T  +
Sbjct: 4063 --YRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIA-PFFTKPL 4119

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS---APSGGEASFN-LSLTAEH 628
                +VV     L C+     P  + WF        S     A   G AS   + +    
Sbjct: 4120 RNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMND 4179

Query: 629  SGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSP 688
            +GN++C A N + ++ S     S  + V  P      P ++ V+           +GS+P
Sbjct: 4180 AGNFTCRATNSVGSKDS-----SGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTP 4234

Query: 689  I-LYWFYHEDVTLGKISAPSGGG---------ASFNLSLT-TEHSGIYSCEADN---GLE 734
            + + WF       G     SGG          +S  L L  T  SG Y+C+  N   G+E
Sbjct: 4235 LTIRWF------KGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVE 4288

Query: 735  AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLG 794
                    L V  P +   +    P      GD  +L C+ + G+P I   +F  D  + 
Sbjct: 4289 CS----ANLFVKEPAT--FVEKLEPSQLLKKGDATQLACK-VTGTPPIKITWFANDREIK 4341

Query: 795  NRSS-----PSGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTL 835
              S          A L L+ +  E SG Y CEA N  G+    ++ +
Sbjct: 4342 ESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVI 4388



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 205/905 (22%), Positives = 347/905 (38%), Gaps = 117/905 (12%)

Query: 16   QFARTPRPIIFLQPPWTTVFQGE-------RVTLTCKGFRFYSPQKTKWYHRYLGKEILR 68
            QF + P P++ L+   +T F+ +       RV+    G    + QK    H     + L 
Sbjct: 4862 QFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQK----HGISFIDGLA 4917

Query: 69   ETPDNILEVQESGEYRCQAQ--GSPLSSPVHLDFSSASLILQ--APLSVFEGDSVVLRCR 124
                +   V+ SG Y C+A+      S  + L        ++   P+ V +   V L C 
Sbjct: 4918 TFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECE 4977

Query: 125  AKAEVTLNNTIYKNDNVLAFLNKRT--------DFHIPHACLKDNGAYRCTGYKESCCPV 176
                     T  KN+  +    K T        + HI      D G Y+C    E     
Sbjct: 4978 VTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCS 5037

Query: 177  SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236
             S  V ++    F + +   ++        V  +  T  S      P+   + +DDQ L 
Sbjct: 5038 CSTRVALKEPPSFIKKIENTTT--------VLKSSATFQSTVAGSPPISITWLKDDQILD 5089

Query: 237  LGWSLSPNF-------QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVL 289
               ++  +F       QI ++ +  SG Y C+A         +   +++ VQ PA     
Sbjct: 5090 EDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKN---ESGVERCYAFLLVQEPAQ---- 5142

Query: 290  TLSPEKALNFEGTK---VTLHC---ETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISF 343
                EKA + + T+   +TL C    T E  ++ L +   + VP R+ S+  E   + SF
Sbjct: 5143 --IVEKAKSVDVTEKDPMTLECVVAGTPELKVKWL-KDGKQIVPSRYFSMSFENNVA-SF 5198

Query: 344  ---SLTTENSGNYYCTADNGLGAKPSKAV--SLSVTVPVSHPVLNLSSPEDLIFEGAKVT 398
               S+  ++SG Y    +N  G+    A    L   +P S     L+  + ++  G+ + 
Sbjct: 5199 RIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSF-TKKLTKMDKVL--GSSIH 5255

Query: 399  LHCEAQRGSLPILYQFHHEG----AALERRSANSAGGVAISF-SLTAEHSGNYYCTADNG 453
            + C+   GSLPI  Q+  +G     + + R       V++   +L  E + NY C   N 
Sbjct: 5256 MECKVS-GSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNV 5314

Query: 454  FGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP 513
             G      + L+V  P   P   +          +TV     + +G+P    +++ +D+ 
Sbjct: 5315 AGDDACSGI-LTVKEP---PSFLVKPGRQQAIPDSTVEFKA-ILKGTPPFKIKWFKDDVE 5369

Query: 514  LWSSSTPSV---GRVSF--SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPIL 568
            L S     +   G  SF   +S+    +G Y C   N  G   S    L VT P   P  
Sbjct: 5370 LVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSD-SCTTMLLVTEP---PKF 5425

Query: 569  TLRVPRAQAV-VGDLLELHCEAPRGSPPI-LYWFYHEDVTLGSSS-----APSGGEASFN 621
              ++  ++ V  GD   L C+   GSP I + WF +E     S         S      N
Sbjct: 5426 VKKLEASKIVKAGDSSRLECKI-AGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMN 5484

Query: 622  LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681
             +L+ E SG++ CEA N      S + S  VIV    P+ +   P  + +    + L CE
Sbjct: 5485 -NLSTEDSGDFICEAQN---PAGSTSCSTKVIVK-EPPVFSSFPPIVETLKNAEVSLECE 5539

Query: 682  ALRGSSPILYWFYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQ 736
             L G+ P    +Y +   L      KI++ +   +   L++ T   G Y C+A N + + 
Sbjct: 5540 -LSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD 5598

Query: 737  RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR 796
               + T+K+  P   P    +        G+  EL   ++ G+  I  ++  E   +   
Sbjct: 5599 TC-VCTVKLKEP---PRFVSKLNSLTVVAGEPAELQA-SIEGAQPIFVQWLKEKEEVIRE 5653

Query: 797  SS------PSGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYI--TGLTANRSGP 847
            S           A+L  +     ++G Y C+  N  G  R    TL +    +   ++GP
Sbjct: 5654 SENIRITFVENVATLQFAKAEPANAGKYICQIKND-GGMRENMATLMVLEPAVIVEKAGP 5712

Query: 848  FATGV 852
                V
Sbjct: 5713 MTVTV 5717



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 207/911 (22%), Positives = 334/911 (36%), Gaps = 150/911 (16%)

Query: 13   VSGQFARTPRPIIF---LQPPWTTVFQGERVTLTCKGFRFYSPQKT-KWYHRYLGKEILR 68
            V G    T  P  F   L+P    V  G+ V+L C+     +P+ T  WY    G   LR
Sbjct: 6068 VCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAG--TPEITVSWYK---GDTKLR 6120

Query: 69   ETPD--------------NILEVQESGEYRCQAQ---GSPLSSPV------HLDFSSASL 105
             TP+              N + + +SGEY C+A+   G+  S  V       L  S A  
Sbjct: 6121 PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQ 6180

Query: 106  ILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL--------AFLNKRTDFHIPHAC 157
            +     +V  G  V L CR      +    Y++  +L        +F++      I    
Sbjct: 6181 LKDIEQTV--GLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTD 6238

Query: 158  LKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV--LRASSFQPISGNPVTLTCETQL 215
            L  +G Y C+    +    +S++ ++  +EP   P   ++  S   I+G      C    
Sbjct: 6239 LSHSGQYSCSA--SNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHV-- 6294

Query: 216  SLERSDVPLRFRFFRDDQTLGLGWSL-------SPNFQITAMWSKDSGFYWCKAATMPYS 268
                   P+R  + +D++ +  G +        +P+ +I  +   DSG Y C+A      
Sbjct: 6295 ---TGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQAT----- 6346

Query: 269  VISDSPRSWIQVQIPASHP---VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG 325
              +D  +     Q+    P   V  L   K    +G  + L C+        +  F ++ 
Sbjct: 6347 --NDVGKDMCSAQLSVKEPPKFVKKLEASKVAK-QGESIQLECKISGSPEIKVSWFRNDS 6403

Query: 326  VPLRHKSVRCERGASISFSLTT------ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH 379
                H+S +       S +L T      E+SG+Y C A NG+G   S + +L+V  P   
Sbjct: 6404 E--LHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVG-DASCSTALTVKAP--- 6457

Query: 380  PVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAIS---- 435
            PV           +G+ V L CE   G+ P    +       +R+   ++    I+    
Sbjct: 6458 PVFTQKPSPVGALKGSDVILQCEIS-GTPPFEVVW-----VKDRKQVRNSKKFKITSKHF 6511

Query: 436  ------FSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGAT 489
                   +L A   G Y+C A N  G   S   S SV      P      ++  T  G  
Sbjct: 6512 DTSLHILNLEASDVGEYHCKATNEVG---SDTCSCSVKFK-EPPRFVKKLSDTSTLIGDA 6567

Query: 490  VTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG-----HSGNYYCTAD 544
            V L   V+   P  +         +  S    +  +    +L  G     +SG Y C   
Sbjct: 6568 VELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIK 6627

Query: 545  NGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAV-VGDLLELHCEAPRGSPPILYWFYHE 603
            N  G +    V     + V  P   +  P    V  G+   L C    G+P +   ++ +
Sbjct: 6628 NDAGMRECSAV-----LTVLEPARIIEKPEPMTVTTGNPFALEC-VVTGTPELSAKWFKD 6681

Query: 604  DVTLGSSSAPS----GGEASFNLSLT-AEHSGNYSCEANNGLVAQHSDTISLSVIVPVSR 658
               L + S          AS  +        G YS E  N  V + + T+S+ V   +  
Sbjct: 6682 GRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNS-VGKSNCTVSVHVSDRIVP 6740

Query: 659  PILTFRAPRAQAVVGDLLELHCEALRGSSPI-LYWFY--HEDVTLGKI-SAPSGGGASFN 714
            P    +     A++G  + L C  + GS+PI + WF   +E V+  K  S+ S    + N
Sbjct: 6741 PSFIRKLKDVNAILGASVVLECR-VSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLN 6799

Query: 715  LS-LTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHC 773
            LS L    +GIY+C A N   +     V     + V  P    + P +   +  +     
Sbjct: 6800 LSLLEPSDTGIYTCVAANVAGSDECSAV-----LTVQEPPSFEQTPDSVEVLPGMSLTFT 6854

Query: 774  EALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSL------------TAEHSGNYSCEA 821
              +RG+P    ++F      G+R     G S N+SL                SG+YSC  
Sbjct: 6855 SVIRGTPPFKVKWFK-----GSRELVP-GESCNISLEDFVTELELFEVQPLESGDYSCLV 6908

Query: 822  DNGLGAQRSET 832
             N  G+    T
Sbjct: 6909 TNDAGSASCTT 6919



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 144/568 (25%), Positives = 221/568 (38%), Gaps = 57/568 (10%)

Query: 301  GTKVTLHCETQEDSLRTLYRFYHEGVPLR----HKSVRCERGASISFSLTTEN-SGNYYC 355
            G  V+L C+       T+  +Y     LR    +++      A++ F+    N SG Y C
Sbjct: 6093 GDSVSLQCQVAGTPEITV-SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTC 6151

Query: 356  TADNGLGAKPSKAVSL--SVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQ 413
             A+N +G   SK V       +P S     L   E  +  G  VTL C    GS PI   
Sbjct: 6152 KAENSIGTASSKTVFRIQERQLPPSF-ARQLKDIEQTV--GLPVTLTCRLN-GSAPIQVC 6207

Query: 414  FHHEGAAL---ERRSANSAGGVAISFSLTAE--HSGNYYCTADNGFGPQRSKAVSLSVTV 468
            ++ +G  L   E    +    VA    L  +  HSG Y C+A N  G   S A  L+   
Sbjct: 6208 WYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSA-RLTARE 6266

Query: 469  PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSP-QILYQFYHEDM-PLWSSSTPSVGRVS 526
            P   P   +         G +    C V    P +I +   ++++ P  + +   VG   
Sbjct: 6267 PKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTP 6326

Query: 527  FS--FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV--GDL 582
                  + +G SG Y C A N  G            + V  P   ++   A  V   G+ 
Sbjct: 6327 HLRILKVGKGDSGQYTCQATNDVGKDMCSA-----QLSVKEPPKFVKKLEASKVAKQGES 6381

Query: 583  LELHCEAPRGSPPI-LYWF-----YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEA 636
            ++L C+   GSP I + WF      HE      S   S    + N   +AE SG+Y CEA
Sbjct: 6382 IQLECKIS-GSPEIKVSWFRNDSELHESWKYNMSFINSVALLTIN-EASAEDSGDYICEA 6439

Query: 637  NNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPI-LYWFYH 695
            +NG V   S + +L+V  P   P+ T +     A+ G  + L CE + G+ P  + W   
Sbjct: 6440 HNG-VGDASCSTALTVKAP---PVFTQKPSPVGALKGSDVILQCE-ISGTPPFEVVWVKD 6494

Query: 696  EDVTLG----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSR 751
                      KI++     +   L+L     G Y C+A N + +      ++K   P   
Sbjct: 6495 RKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSC-SVKFKEP--- 6550

Query: 752  PVLTLRAPGTHAAVGDLLELHC--EALRGSPLILYRFFHEDVTLGNRSSPS---GGASLN 806
            P    +   T   +GD +EL    E  +   ++  +   E +     +  S     A+L 
Sbjct: 6551 PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQ 6610

Query: 807  L-SLTAEHSGNYSCEADNGLGAQRSETV 833
            L S  A +SG Y C+  N  G +    V
Sbjct: 6611 LGSPEASNSGKYICQIKNDAGMRECSAV 6638



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 204/888 (22%), Positives = 317/888 (35%), Gaps = 145/888 (16%)

Query: 34   VFQGERVTLTCKGFRFYSPQKTKWY----HRYLGKEILRETPDNI-------LEVQESGE 82
            V QG+  TL  K F        KW+       LG +      D +        E ++SGE
Sbjct: 4590 VTQGDPATLQVK-FSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGE 4648

Query: 83   YRCQAQGSPLSSPVHLDFSSASLILQAP-------LSVFEGDSVVLRCRAKAEVTLNNTI 135
            Y  + Q     S      +   LI+          +   +G  + L C       ++   
Sbjct: 4649 YTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQW 4708

Query: 136  YKNDNVLAFLNK-RTDFHIPHACLK-------DNGAYRCTGYKESCCPVSSNTVKIQVQE 187
            +K+D  ++   K +  FH   A L+       D+G Y C+   ++     S  + ++   
Sbjct: 4709 FKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVK--- 4765

Query: 188  PFTRPVLRASSFQPISGNPVTLTCETQL-SLERSDVPLRFRFFRDDQTLGLG-----WS- 240
                P       Q    NP T     QL +L     P+  ++F+D++ L  G     W  
Sbjct: 4766 ---EPPYFVEKPQSQDVNPNT---RVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKD 4819

Query: 241  -LSPNFQITAMWSKDSGFYWCK------AATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293
              S + ++ A  + DSG Y C+       AT   ++    P  +I+       PVL L  
Sbjct: 4820 DTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIK----KPSPVLVLR- 4874

Query: 294  EKALNFEGTKVTLHCE-TQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTT----- 347
                   G   T  C+ T    +R  +  Y +G  +   +   + G S    L T     
Sbjct: 4875 ------NGQSTTFECQITGTPKIRVSW--YLDGNEI---TAIQKHGISFIDGLATFQISG 4923

Query: 348  ---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEA 403
               ENSG Y C A N  G       S S+ + V  P   +   + + + + + V L CE 
Sbjct: 4924 ARVENSGTYVCEARNDAGT-----ASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEV 4978

Query: 404  QRGSLPILYQFHHEGAALERRSANSAGGVAISFSL-----TAEHSGNYYCTADNGFGPQR 458
              G+ P    +      +      +       F+L         +G Y C   N  G   
Sbjct: 4979 T-GTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGG--- 5034

Query: 459  SKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILY------QFYHEDM 512
              + S S  V +  P   +   E  T    +         GSP I        Q   ED 
Sbjct: 5035 --SCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDD 5092

Query: 513  PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572
             ++ S   SV  +    S+  GHSG Y C A N  G +R     L V  P     +  + 
Sbjct: 5093 NVYISFVDSVATLQIR-SVDNGHSGRYTCQAKNESGVERC-YAFLLVQEPAQ---IVEKA 5147

Query: 573  PRAQAVVGDLLELHCEAPRGSPPI-LYWFYHEDVTLGS---SSAPSGGEASFNL-SLTAE 627
                    D + L C    G+P + + W       + S   S +     ASF + S+  +
Sbjct: 5148 KSVDVTEKDPMTLEC-VVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQ 5206

Query: 628  HSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSS 687
             SG Y+ +  N   +   D   L V+     P  T +  +   V+G  + + C+ + GS 
Sbjct: 5207 DSGQYTFKVENDFGSSSCDAY-LRVLDQNIPPSFTKKLTKMDKVLGSSIHMECK-VSGSL 5264

Query: 688  PI-LYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746
            PI   WF        K        A + L     H    S E +N LE + +   T KV+
Sbjct: 5265 PISAQWF--------KDGKEISTSAKYRLVC---HERSVSLEVNN-LELEDTANYTCKVS 5312

Query: 747  -----------VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGN 795
                       + V  P   L  PG   A+ D        L+G+P    ++F +DV L  
Sbjct: 5313 NVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVEL-- 5370

Query: 796  RSSP------SGGAS-LNL-SLTAEHSGNYSCEADNGLGAQRSETVTL 835
             S P       G  S LNL S+ A  +G Y+C   N +G+    T+ L
Sbjct: 5371 VSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLL 5418



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 184/814 (22%), Positives = 297/814 (36%), Gaps = 94/814 (11%)

Query: 76   EVQESGEYRCQAQ---GSPLSSPVHLDFSSASLILQA-PLSVFEGDSVVLRCRAKAEVTL 131
            E   SG+Y CQ +   G    S V      A +I +  P++V  G+   L C       L
Sbjct: 6615 EASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPEL 6674

Query: 132  NNTIYKNDNVLA--------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
            +   +K+   L+        F+NK     IP A + D G Y      ++    S+ TV +
Sbjct: 6675 SAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFE--VKNSVGKSNCTVSV 6732

Query: 184  QVQEPFTRP--VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSL 241
             V +    P  + +      I G  V L C    S      P+   +F+D   +  G   
Sbjct: 6733 HVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGS-----APISVGWFQDGNEIVSGPKC 6787

Query: 242  SPNFQ-------ITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294
              +F        ++ +   D+G Y C AA +  S   D   + + VQ P S      S E
Sbjct: 6788 QSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS---DECSAVLTVQEPPSFEQTPDSVE 6844

Query: 295  KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASIS--FSLTTENSGN 352
                   T  ++   T    ++  ++   E VP    ++  E   +    F +    SG+
Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKW-FKGSRELVPGESCNISLEDFVTELELFEVQPLESGD 6903

Query: 353  YYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE-GAKVTLHCEAQRGSLPIL 411
            Y C   N  G+      S +  + V  P   +    D   E G+ + L      G+ PI 
Sbjct: 6904 YSCLVTNDAGS-----ASCTTHLFVKEPATFVKRLADFSVETGSPIVLEA-TYTGTPPIS 6957

Query: 412  YQFHHEGAALERRSANSAGGVAISFSL-----TAEHSGNYYCTADNGFGPQRSKAVSLSV 466
              +  +   + +    S      S  L     T E    Y C  +N  G    +A+ +SV
Sbjct: 6958 VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEAL-VSV 7016

Query: 467  TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVS 526
              P  + +  L   EA+  E AT  L C+V  G+P+I   +Y E   L S+    +   +
Sbjct: 7017 LEP-PYFIEPLEHVEAVIGEPAT--LQCKVD-GTPEIRISWYKEHTKLRSAPAYKMQFKN 7072

Query: 527  FSFSLTEG---HS--GNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGD 581
               SL      HS  G Y C ADN  G   S  V L +      P    ++      +G 
Sbjct: 7073 NVASLVINKVDHSDVGEYSCKADNSVGAVASSAV-LVIKARKLPPFFARKLKDVHETLGF 7131

Query: 582  LLELHCEAPRGSPPILYWF-----YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEA 636
             +   C      P  + W+       +D  L +S   +       L     H G Y+C A
Sbjct: 7132 PVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQI-LQTDQSHIGQYNCSA 7190

Query: 637  NNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHE 696
            +N L    S +  L +      P    +       +G+     C  + G++PI       
Sbjct: 7191 SNPL-GTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCH-VTGTAPI------- 7241

Query: 697  DVTLGKISAPSGGGASFNLSLTTE------------HSGIYSCEADNGLEAQRSEMVTLK 744
             +T  K +     G ++ ++L                +G Y+C A N +  + S    L 
Sbjct: 7242 KITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASN-IAGKDSCSAQLG 7300

Query: 745  VAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----P 799
            V  P  R +  L  P       +     C+ + GSP I   ++ ++  +   S       
Sbjct: 7301 VQEP-PRFIKKLE-PSRIVKQDEFTRYECK-IGGSPEIKVLWYKDETEIQESSKFRMSFV 7357

Query: 800  SGGASLNL-SLTAEHSGNYSCEADNGLGAQRSET 832
               A L + +L+ E SG+Y+CEA N  G+  S T
Sbjct: 7358 DSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 176/822 (21%), Positives = 302/822 (36%), Gaps = 121/822 (14%)

Query: 79   ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---LSVFEGDSVVLR-------CRAKAE 128
            ++G+Y C A     S+    D  SA L +Q P   +   E   +V +       C+    
Sbjct: 7278 DAGQYTCYA-----SNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGS 7332

Query: 129  VTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180
              +    YK++  +        +F++      + +  ++D+G Y C  +  +    SS +
Sbjct: 7333 PEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTS 7392

Query: 181  VKIQVQEPFTRPVLRAS--SFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLG 238
            +K  V+EP   P+ R      + + G  V L CE Q        P    +++D + L  G
Sbjct: 7393 LK--VKEP---PIFRKKPHPIETLKGADVHLECELQ-----GTPPFHVSWYKDKRELRSG 7442

Query: 239  WS---LSPNF----QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291
                 +S NF     I  + + D G Y CKA      V SD+    I ++ P   P    
Sbjct: 7443 KKYKIMSENFLTSIHILNVDAADIGEYQCKATN---DVGSDTCVGSIALKAP---PRFVK 7496

Query: 292  SPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKS----VRCERGASISFS-LT 346
                     G +V L    +     ++  F  +G  +R          E  A++ FS + 
Sbjct: 7497 KLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVE 7556

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEAQR 405
              N+G Y C   N  G +   A     T+ V  P   +  PE + +  G   TL C    
Sbjct: 7557 PANAGKYTCQIKNDAGMQECFA-----TLSVLEPATIVEKPESIKVTTGDTCTLECTV-A 7610

Query: 406  GSLPILYQFHHEGAALERRSA------NSAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459
            G+  +  ++  +G  L   +       N   G+ I  ++    SG Y     N  G + S
Sbjct: 7611 GTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKI-INVAPSDSGVYSFEVQNPVG-KDS 7668

Query: 460  KAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSST 519
               SL V+     P  T    E     G++V + C+V  GSP I   ++HE   + S   
Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY-GSPPISVSWFHEGNEISSGRK 7727

Query: 520  PSVGRVSFSFSLT-----EGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPR 574
                    + +LT     E  SG+Y C A N  G            + V  P   ++ P 
Sbjct: 7728 YQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECS-----APLTVREPPSFVQKPD 7782

Query: 575  AQAVVGDLLELHCEAPRGSPPI-LYWFYHEDVTLGSSSAPSGGEASFNL----------S 623
               V+           +G+PP  + WF       GSS    G   + +L           
Sbjct: 7783 PMDVLTGTNVTFTSIVKGTPPFSVSWF------KGSSELVPGDRCNVSLEDSVAELELFD 7836

Query: 624  LTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVS--RPILTFRAPRAQAVVGDLLELHCE 681
            +    SG Y+C  +N    + S T  L +  P    + +  +   + + ++ +       
Sbjct: 7837 VDTSQSGEYTCIVSNE-AGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILE------G 7889

Query: 682  ALRGSSPILYWFYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQ 736
               G+ PI   +    + +       I+           S T E +G Y+C  +N   A 
Sbjct: 7890 TFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIEN---AS 7946

Query: 737  RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR 796
              +  + ++ + +  P    +      +VGD   L C+ L G+P I   ++  D  L   
Sbjct: 7947 GKDSCSAQILI-LEPPYFVKQLEPVKVSVGDSASLQCQ-LAGTPEIGVSWYKGDTKLRPT 8004

Query: 797  SSPSGGASLNLS------LTAEHSGNYSCEADNGLGAQRSET 832
            ++       N++      +    SG Y C+A+N +G   + T
Sbjct: 8005 TTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAST 8046



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 190/825 (23%), Positives = 307/825 (37%), Gaps = 117/825 (14%)

Query: 73   NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLN 132
            N L  ++SG++ C+AQ     +P      S  +I++ P  VF     ++     AEV+L 
Sbjct: 5484 NNLSTEDSGDFICEAQ-----NPAGSTSCSTKVIVKEP-PVFSSFPPIVETLKNAEVSLE 5537

Query: 133  NTI----------YKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCC 174
              +          YK+   L        A  N  T  HI +    D G Y C    E   
Sbjct: 5538 CELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 5597

Query: 175  PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
                 TVK++  EP  R V + +S   ++G P     E Q S+E +  P+  ++ ++ + 
Sbjct: 5598 DTCVCTVKLK--EP-PRFVSKLNSLTVVAGEPA----ELQASIEGAQ-PIFVQWLKEKEE 5649

Query: 235  LGLGWSLSPNFQITAMWS-----------KDSGFYWCKAATMPYSVISDSPRSWIQVQIP 283
            +      S N +IT + +            ++G Y C+       + +D         + 
Sbjct: 5650 V---IRESENIRITFVENVATLQFAKAEPANAGKYICQ-------IKNDGGMRENMATLM 5699

Query: 284  ASHPVLTLSPEKALNFE-GTKVTLHCE---TQEDSLRTLYRFYHEGVPL----RHKSVRC 335
               P + +     +    G   TL C+   T E S+     +Y +G  L    +HK    
Sbjct: 5700 VLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVE----WYKDGKLLTSSQKHKFSFY 5755

Query: 336  ERGASISF-SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEG 394
             + +S+   S+  +++G Y     N +G     AV + V+     P             G
Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAV-VDVSDRAVPPSFTRRLKNTGGVLG 5814

Query: 395  AKVTLHCEAQRGSLPILYQFHHE------GAALERRSANSAGGVAISFSLTAEHSGNYYC 448
            A   L C+   GS PI   + HE      GA  +   +++   + ++ SL +   GNY C
Sbjct: 5815 ASCILECKVA-GSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLN-SLDSSDMGNYTC 5872

Query: 449  TADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFY 508
             A N  G    +AV L+V  P S  V      E L  +  T T    V RG+P     ++
Sbjct: 5873 VAANVAGSDECRAV-LTVQEPPSF-VKEPEPLEVLPGKNVTFT---SVIRGTPPFKVNWF 5927

Query: 509  HEDMPLWSSST------PSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVP 562
                 L            +V  +   F++    SG Y C   N  G Q S    LFV  P
Sbjct: 5928 RGARELVKGDRCNIYFEDTVAELEL-FNIDISQSGEYTCVVSNNAG-QASCTTRLFVKEP 5985

Query: 563  VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFN- 621
             +      R+       G  + L      G+ PI   +  +   + +S   +        
Sbjct: 5986 AA---FLKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTC 6041

Query: 622  ----LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLE 677
                L+ T   +G YSCE  N    +    +  +++  +  P         +A VGD + 
Sbjct: 6042 ILEILNSTKRDAGQYSCEIEN----EAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVS 6097

Query: 678  LHCEALRGSSPILYWFYHEDVTLGKIS------APSGGGASFNLSLTTEHSGIYSCEADN 731
            L C+ + G+  I   +Y  D  L            +     FN  +    SG Y+C+A+N
Sbjct: 6098 LQCQ-VAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFN-KVNINDSGEYTCKAEN 6155

Query: 732  GLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDV 791
             +    S+ V  ++      P    +       VG  + L C  L GS  I   ++ + V
Sbjct: 6156 SIGTASSKTV-FRIQERQLPPSFARQLKDIEQTVGLPVTLTCR-LNGSAPIQVCWYRDGV 6213

Query: 792  TLGN-----RSSPSGGASLNLSLT-AEHSGNYSCEADNGLGAQRS 830
             L +      S     A+L +  T   HSG YSC A N LG   S
Sbjct: 6214 LLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASS 6258



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 164/814 (20%), Positives = 294/814 (36%), Gaps = 102/814 (12%)

Query: 80   SGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEVT 130
            SG Y CQA+         ++   A L++Q P         + V E D + L C       
Sbjct: 5115 SGRYTCQAKNES-----GVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPE 5169

Query: 131  LNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRC---TGYKESCCPVSSN 179
            L     K+   +        +F N    F I     +D+G Y       +  S C     
Sbjct: 5170 LKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLR 5229

Query: 180  TVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW 239
             +   +   FT+   + +    + G+ + + C+   SL     P+  ++F+D + +    
Sbjct: 5230 VLDQNIPPSFTK---KLTKMDKVLGSSIHMECKVSGSL-----PISAQWFKDGKEISTSA 5281

Query: 240  SL-------SPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLS 292
                     S + ++  +  +D+  Y CK + +      D+    + V+ P   P   + 
Sbjct: 5282 KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGD---DACSGILTVKEP---PSFLVK 5335

Query: 293  PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASIS------FSLT 346
            P +      + V      +      + +++ + V L     +C  G   S      +S+ 
Sbjct: 5336 PGRQQAIPDSTVEFKAILKGTPPFKI-KWFKDDVELV-SGPKCFIGLEGSTSFLNLYSVD 5393

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406
               +G Y C   N +G+     + L    P     L  S    ++  G    L C+   G
Sbjct: 5394 ASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASK---IVKAGDSSRLECKIA-G 5449

Query: 407  SLPIL---YQFHHEGAALERRSANSAGGVAI--SFSLTAEHSGNYYCTADNGFGPQRSKA 461
            S  I    ++  HE  A ++        VA+    +L+ E SG++ C A N  G     +
Sbjct: 5450 SPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAG-----S 5504

Query: 462  VSLSVTVPVSHPVLTLSSAEAL-TFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTP 520
             S S  V V  P +  S    + T + A V+L CE+  G+P     +Y +   L SS   
Sbjct: 5505 TSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELS-GTPPFEVVWYKDKRQLRSSKKY 5563

Query: 521  SVGRVSFSFSL-----TEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRA 575
             +   +F  S+          G Y+C A N  G     V ++ +  P   P    ++   
Sbjct: 5564 KIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTC-VCTVKLKEP---PRFVSKLNSL 5619

Query: 576  QAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS------APSGGEASFNLSLTAEHS 629
              V G+  EL        P  + W   ++  +  S         +     F  +  A ++
Sbjct: 5620 TVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPA-NA 5678

Query: 630  GNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPI 689
            G Y C+  N       +  +L V+ P    ++  +A      VG+   L C+        
Sbjct: 5679 GKYICQIKND-GGMRENMATLMVLEPA---VIVEKAGPMTVTVGETCTLECKVAGTPELS 5734

Query: 690  LYWFYHEDVTLG----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKV 745
            + W+    +       K S  +   +   LS+  + +G Y+ +  N +  + S    + V
Sbjct: 5735 VEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNV-GKSSCTAVVDV 5793

Query: 746  AVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASL 805
            +     P  T R   T   +G    L C+    SP+ +  +FHE   + + +      S 
Sbjct: 5794 SDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISV-AWFHEKTKIVSGAKYQTTFSD 5852

Query: 806  NL------SLTAEHSGNYSCEADNGLGAQRSETV 833
            N+      SL +   GNY+C A N  G+     V
Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 192/836 (22%), Positives = 312/836 (37%), Gaps = 111/836 (13%)

Query: 75   LEVQESGEYRCQAQGS--PLSSPVHLDFSSASLILQA--PLSVFEGDSVVLRCRAKAEVT 130
            L V++SG+Y C+A  +    SS   L      +  +   P+   +G  V L C  +    
Sbjct: 7368 LSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPP 7427

Query: 131  LNNTIYKNDNVLAFLNK--------RTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTV- 181
             + + YK+   L    K         T  HI +    D G Y+C    +    V S+T  
Sbjct: 7428 FHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATND----VGSDTCV 7483

Query: 182  -KIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD-----QTL 235
              I ++ P  R V + S    + G  V L    Q ++E ++ P+   +F+D      ++ 
Sbjct: 7484 GSIALKAP-PRFVKKLSDISTVVGKEVQL----QTTIEGAE-PISVVWFKDKGEIVRESD 7537

Query: 236  GLGWSLSPN---FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP-VLTL 291
             +  S S N    Q + +   ++G Y C+       + +D+        +    P  +  
Sbjct: 7538 NIWISYSENIATLQFSRVEPANAGKYTCQ-------IKNDAGMQECFATLSVLEPATIVE 7590

Query: 292  SPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISF-------- 343
             PE      G   TL C T   +     +++ +G     K +  +    ISF        
Sbjct: 7591 KPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDG-----KELTSDNKYKISFFNKVSGLK 7644

Query: 344  --SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHC 401
              ++   +SG Y     N +G K S   SL V+     P       E     G+ V + C
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVG-KDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703

Query: 402  EAQRGSLPILYQFHHEG----AALERRSANSAGGVAISFSLTAE-HSGNYYCTADNGFGP 456
            +   GS PI   + HEG    +  + ++  +    A++ ++  E  SG+Y C A N  G 
Sbjct: 7704 KVY-GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGS 7762

Query: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516
                A  L+V  P S  V      + LT    T T    + +G+P     ++     L  
Sbjct: 7763 DECSA-PLTVREPPSF-VQKPDPMDVLTGTNVTFT---SIVKGTPPFSVSWFKGSSELVP 7817

Query: 517  ------SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTL 570
                  S   SV  +   F +    SG Y C   N  G + S    L++  P        
Sbjct: 7818 GDRCNVSLEDSVAELEL-FDVDTSQSGEYTCIVSNEAG-KASCTTHLYIKAPAK---FVK 7872

Query: 571  RVPRAQAVVGDLLELHCEAPRGSPPILYWFYHE--DVTLGSSSAPSGGEASFNL---SLT 625
            R+       G  L L      G+PPI   +     +VT       +  E S  L   S T
Sbjct: 7873 RLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSST 7931

Query: 626  AEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRG 685
             E +G Y+C   N   A   D+ S  +++ +  P    +    +  VGD   L C+ L G
Sbjct: 7932 VEDAGQYNCYIEN---ASGKDSCSAQILI-LEPPYFVKQLEPVKVSVGDSASLQCQ-LAG 7986

Query: 686  SSPILYWFYHED-----VTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740
            +  I   +Y  D      T  K+   +         +    SG Y C+A+N +  + S  
Sbjct: 7987 TPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSV-GEVSAS 8045

Query: 741  VTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800
              L V      P  + +       VG  +   C A+ GS  I   ++ +   L  + SP+
Sbjct: 8046 TFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC-AISGSEPISVSWYKDGKPL--KDSPN 8102

Query: 801  -------GGASLNLSLTAEH-SGNYSCEADNGLGAQRSETVTLYITGLTANRSGPF 848
                     A+LN+  T    +G YSC A N +G+  S    +    LT  ++ PF
Sbjct: 8103 VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLI----LTEGKNPPF 8154



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 183/852 (21%), Positives = 303/852 (35%), Gaps = 126/852 (14%)

Query: 54   KTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQ---AP 110
            K  ++++  G +I+   P       +SG Y  + Q     +PV  D  +ASL +     P
Sbjct: 7633 KISFFNKVSGLKIINVAPS------DSGVYSFEVQ-----NPVGKDSCTASLQVSDRTVP 7681

Query: 111  LSV---------FEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACL--- 158
             S            G SVV+ C+      ++ + +   N ++   K       + C    
Sbjct: 7682 PSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTV 7741

Query: 159  -----KDNGAYRC-----TGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVT 208
                  D+G Y C      G  E   P++       VQ+P    VL        +G  VT
Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVL--------TGTNVT 7793

Query: 209  LTCETQLSLERSDVPLRFRFFRDDQTLGLG----WSLSPNFQITAMWSKD---SGFYWCK 261
             T     S+ +   P    +F+    L  G     SL  +     ++  D   SG Y C 
Sbjct: 7794 FT-----SIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848

Query: 262  AATMPYSVISDSPRSWIQVQIPASHPV----LTLSPEKALNFEGTKVTLHCETQEDSLRT 317
             +         S  + + ++ PA         ++   K L  EGT       T   S+  
Sbjct: 7849 VSNEAGKA---SCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGT----FTGTPPISVTW 7901

Query: 318  LYRFYHEGVPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVP 376
                 +     R      E+ A +   S T E++G Y C  +N  G       S S  + 
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKD-----SCSAQIL 7956

Query: 377  VSHPVLNLSSPEDL-IFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSA-------NS 428
            +  P   +   E + +  G   +L C  Q    P +    ++G    R +        N+
Sbjct: 7957 ILEPPYFVKQLEPVKVSVGDSASLQC--QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNN 8014

Query: 429  AGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGA 488
               +  +  +    SG Y C A+N  G + S +  L+V      P  +    +     G 
Sbjct: 8015 VATLVFN-QVDINDSGEYICKAENSVG-EVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072

Query: 489  TVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFS-----FSLTEGHSGNYYCTA 543
             V   C +  GS  I   +Y +  PL  S       +  +     F      +G Y CTA
Sbjct: 8073 PVVFDCAIS-GSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTA 8131

Query: 544  DNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHE 603
             N  G   S    L +T   + P   +R+    AVVG+  +  C      P  + W    
Sbjct: 8132 TNPIGSASSSA-RLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSW---- 8186

Query: 604  DVTLGSSSAPSGGEASFNLSLTAEH----------SGNYSCEANNGLVAQHSDTISLSVI 653
                 S    SGG+   +    + H          SG Y+C A N  V + S T  L++ 
Sbjct: 8187 --AKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNE-VGKDSCTAQLNIK 8243

Query: 654  VPVSRPILTFR-APRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGAS 712
              +  P  T R +   +   G+  +L    + GS PI   +Y  ++ +   S       +
Sbjct: 8244 ERLIPPSFTKRLSETVEETEGNSFKLEGR-VAGSQPITVAWYKNNIEIQPTSNCEITFKN 8302

Query: 713  FNLSLTTEHSG-----IYSCEADNGLEAQRSEMVTLKVAV--PVSRPVLTLRAPGTHAAV 765
              L L    +G     +Y+C+  N      S + T  + +  P   PV          + 
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAG---SALCTSSIVIKEPKKPPVFDQHLTPVTVSE 8359

Query: 766  GDLLELHCEALRGSPL-ILYRFFHEDVTLGNRSS---PSGGASLNLSLTAE-HSGNYSCE 820
            G+ ++L C      P+ I +     ++   +R S    SG A L L   A+  SG+Y C+
Sbjct: 8360 GEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCK 8419

Query: 821  ADNGLGAQRSET 832
            A N  G+  +++
Sbjct: 8420 ASNVAGSDTTKS 8431



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 195/841 (23%), Positives = 311/841 (36%), Gaps = 131/841 (15%)

Query: 79   ESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF----------EGDSVVLRCRAKAE 128
            +SG+Y CQA     ++ V  D  SA L ++ P              +G+S+ L C+    
Sbjct: 6337 DSGQYTCQA-----TNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGS 6391

Query: 129  VTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180
              +  + ++ND+ L        +F+N      I  A  +D+G Y C  +        S  
Sbjct: 6392 PEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTA 6451

Query: 181  VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240
            + ++    FT+   + S    + G+ V L CE          P    + +D + +     
Sbjct: 6452 LTVKAPPVFTQ---KPSPVGALKGSDVILQCEIS-----GTPPFEVVWVKDRKQV----R 6499

Query: 241  LSPNFQITA-----------MWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVL 289
             S  F+IT+           + + D G Y CKA      V SD+    ++ + P    V 
Sbjct: 6500 NSKKFKITSKHFDTSLHILNLEASDVGEYHCKATN---EVGSDTCSCSVKFKEPPRF-VK 6555

Query: 290  TLSPEKALNFEGTKVTLHCET-QEDSLRTLYRFYHEGVPLRHKSVRCERGASISF----- 343
             LS    L  +  ++    E  Q  S+  L          R + +R      ISF     
Sbjct: 6556 KLSDTSTLIGDAVELRAIVEGFQPISVVWLKD--------RGEVIRESENTRISFIDNIA 6607

Query: 344  -----SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKV 397
                 S    NSG Y C   N  G +   AV     + V  P   +  PE + +  G   
Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAV-----LTVLEPARIIEKPEPMTVTTGNPF 6662

Query: 398  TLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLT---AEHS--GNYYCTADN 452
             L C    G+  +  ++  +G  L   S +    +    SL    AE S  G Y     N
Sbjct: 6663 ALECVVT-GTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKN 6721

Query: 453  GFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDM 512
              G      VS+ V+  +  P       +     GA+V L C V  GS  I   ++ +  
Sbjct: 6722 SVGKSNC-TVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVS-GSAPISVGWFQDGN 6779

Query: 513  PLWSS----STPSVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPI 567
             + S     S+ S    + + SL E   +G Y C A N  G      V     + V  P 
Sbjct: 6780 EIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAV-----LTVQEPP 6834

Query: 568  LTLRVPRAQAVVGDLLELHCEAPRGSPPI-LYWFY-HEDVTLGSSSAPSGGEASFNLSLT 625
               + P +  V+  +        RG+PP  + WF    ++  G S   S  +    L L 
Sbjct: 6835 SFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELF 6894

Query: 626  AEH---SGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
                  SG+YSC     LV   + + S +  + V  P  TF    A   V     +  EA
Sbjct: 6895 EVQPLESGDYSC-----LVTNDAGSASCTTHLFVKEPA-TFVKRLADFSVETGSPIVLEA 6948

Query: 683  L-RGSSPILYWFYHEDVTLGK-----ISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQ 736
               G+ PI   +  ++  + +     I+          L  T E    YSC  +N    +
Sbjct: 6949 TYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIEN----E 7004

Query: 737  RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR 796
              + +   +   +  P          A +G+   L C+ + G+P I   ++ E   L  R
Sbjct: 7005 AGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCK-VDGTPEIRISWYKEHTKL--R 7061

Query: 797  SSPS-------GGASLNLSLTAEHS--GNYSCEADNGLGAQRSETVTLYITGLTANRSGP 847
            S+P+         ASL ++   +HS  G YSC+ADN +GA  S  V +    + A +  P
Sbjct: 7062 SAPAYKMQFKNNVASLVIN-KVDHSDVGEYSCKADNSVGAVASSAVLV----IKARKLPP 7116

Query: 848  F 848
            F
Sbjct: 7117 F 7117



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 186/827 (22%), Positives = 307/827 (37%), Gaps = 121/827 (14%)

Query: 75   LEVQESGEYRCQAQ---GSPLSSPVHLDFSSASLI--LQAPLSVFEGDSVVLRCRAKAEV 129
            ++  ++G+Y C      GS   + + L       +  L+A   V  GDS  L C+     
Sbjct: 5392 VDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSP 5451

Query: 130  TLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTV 181
             +    ++N++ L         F++      + +   +D+G + C    ++    +S + 
Sbjct: 5452 EIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEA--QNPAGSTSCST 5509

Query: 182  KIQVQEPFTRPVLRASSFQPI----SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGL 237
            K+ V+EP   PV   SSF PI        V+L CE          P    +++D + L  
Sbjct: 5510 KVIVKEP---PVF--SSFPPIVETLKNAEVSLECELS-----GTPPFEVVWYKDKRQLRS 5559

Query: 238  GWSL---SPNFQ----ITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290
                   S NF     I  + + D G Y CKA      V SD+    ++++ P    V  
Sbjct: 5560 SKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQN---EVGSDTCVCTVKLKEPPRF-VSK 5615

Query: 291  LSPEKALNFEGTKVTLHCETQEDS----LRTLYRFYHEGVPLRHKSVRCERGASISFSLT 346
            L+    +  E  ++    E  +      L+       E   +R   V  E  A++ F+  
Sbjct: 5616 LNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFV--ENVATLQFAKA 5673

Query: 347  TE-NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEAQ 404
               N+G Y C   N  G + + A     T+ V  P + +     + +  G   TL C+  
Sbjct: 5674 EPANAGKYICQIKNDGGMRENMA-----TLMVLEPAVIVEKAGPMTVTVGETCTLECKVA 5728

Query: 405  RGSLPILYQFHHEGAALERRSA------NSAGGVAISFSLTAEHSGNYYCTADNGFGPQR 458
             G+  +  +++ +G  L           N    + I  S+  + +G Y     N  G   
Sbjct: 5729 -GTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRI-LSVERQDAGTYTFQVQNNVGKSS 5786

Query: 459  SKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS 518
              AV + V+     P  T          GA+  L C+V   SP I   ++HE   + S +
Sbjct: 5787 CTAV-VDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSP-ISVAWFHEKTKIVSGA 5844

Query: 519  ------TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572
                  + +V  +  + SL     GNY C A N  G      V     + V  P   ++ 
Sbjct: 5845 KYQTTFSDNVCTLQLN-SLDSSDMGNYTCVAANVAGSDECRAV-----LTVQEPPSFVKE 5898

Query: 573  PRAQAVVGDLLELHCEAPRGSPPI-LYWFYHEDVTLGSSSAPSGGEAS------------ 619
            P    V+           RG+PP  + WF       G+     G   +            
Sbjct: 5899 PEPLEVLPGKNVTFTSVIRGTPPFKVNWFR------GARELVKGDRCNIYFEDTVAELEL 5952

Query: 620  FNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELH 679
            FN+ ++   SG Y+C  +N    Q S T  L V  P +      R        G  + L 
Sbjct: 5953 FNIDIS--QSGEYTCVVSNN-AGQASCTTRLFVKEPAA---FLKRLSDHSVEPGKSIILE 6006

Query: 680  CEALRGSSPILYWFYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLE 734
                 G+ PI   +  +   +       I           L+ T   +G YSCE +N  E
Sbjct: 6007 -STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIEN--E 6063

Query: 735  AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLG 794
            A R   V   +   +  P          AAVGD + L C+ + G+P I   ++  D  L 
Sbjct: 6064 AGRD--VCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQ-VAGTPEITVSWYKGDTKL- 6119

Query: 795  NRSSP-------SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETV 833
             R +P       +  A+L  + +    SG Y+C+A+N +G   S+TV
Sbjct: 6120 -RPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTV 6165



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 193/911 (21%), Positives = 331/911 (36%), Gaps = 169/911 (18%)

Query: 14   SGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR----------YLG 63
            SG       P    +P    V  G  V L    F+  +P   +W+            Y+ 
Sbjct: 4197 SGALIVQEPPSFVTKPGSKDVLPGSAVCLKST-FQGSTPLTIRWFKGNKELVSGGSCYIT 4255

Query: 64   KEILRETPD-NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFE------- 115
            KE L  + +  +++  +SG Y C+   S ++  V     SA+L ++ P +  E       
Sbjct: 4256 KEALESSLELYLVKTSDSGTYTCKV--SNVAGGVEC---SANLFVKEPATFVEKLEPSQL 4310

Query: 116  ---GDSVVLRCRAKAEVTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAY 164
               GD+  L C+      +  T + ND  +        +F+       +    ++D+G Y
Sbjct: 4311 LKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEY 4370

Query: 165  RCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDV-P 223
             C    E+     S+ V ++    FT+       F+PI    V    +  L  E +   P
Sbjct: 4371 MCEAQNEAGSDHCSSIVIVKESPYFTK------EFKPIE---VLKEYDVMLLAEVAGTPP 4421

Query: 224  LRFRFFRDDQTLGLGWSLSP-------NFQITAMWSKDSGFYWCKAATMPYSVISDS--- 273
                +F+D+  L  G            + QI    + D+G Y C+      S I  +   
Sbjct: 4422 FEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVT 4481

Query: 274  ---PRSWIQVQIPASHPV--------LTLSPEKALNFEGTKVTLHCETQEDSLRTLYR-- 320
               P S+I+ +I ++  +         TL     +     K +    T++D++R  +   
Sbjct: 4482 LREPPSFIK-KIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEI-TEDDNIRMTFENN 4539

Query: 321  ---FYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPV 377
                Y  G+ ++H                    G Y C A N  G +   A+ LSV  P 
Sbjct: 4540 VASLYLSGIEVKH-------------------DGKYVCQAKNDAGIQRCSAL-LSVKEPA 4579

Query: 378  SHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALE-----RRSANSAGGV 432
            +   +   +    + +G   TL  +   G+  I  ++  +G  L      + S      +
Sbjct: 4580 T---ITEEAVSIDVTQGDPATLQVKFS-GTKEITAKWFKDGQELTLGSKYKISVTDTVSI 4635

Query: 433  AISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTL 492
                S   + SG Y     N  G    KA  ++V   +  P  T    +  + +G+ + L
Sbjct: 4636 LKIISTEKKDSGEYTFEVQNDVGRSSCKA-RINVLDLIIPPSFTKKLKKMDSIKGSFIDL 4694

Query: 493  HCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF---------SLTEG-HSGNYYCT 542
             C +  GS  I  Q++ +D  + +S      +  FSF         S  EG  SG Y C+
Sbjct: 4695 EC-IVAGSHPISIQWFKDDQEISASE-----KYKFSFHDNTAFLEISQLEGTDSGTYTCS 4748

Query: 543  ADNGFGPQRS------EVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPI 596
            A N  G  +       +    FV  P S+ +      + +A+VG           G+ P+
Sbjct: 4749 ATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVG-----------GTAPM 4797

Query: 597  LYWFYHEDVTLGSSSAPSGGEASFNLSL-----TAEHSGNYSCEANNGLVAQHSDTISLS 651
               ++ ++  L S +A S  +   + SL      A  SG Y C+ +N +      T +  
Sbjct: 4798 TIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDV-----GTATSK 4852

Query: 652  VIVPVSRPILTFRAPRAQAVV--GDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG 709
              + V  P    + P    V+  G      C+ + G+  I   +Y +     +I+A    
Sbjct: 4853 ATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQ-ITGTPKIRVSWYLDG---NEITAIQKH 4908

Query: 710  GASFNLSLTT--------EHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGT 761
            G SF   L T        E+SG Y CEA N      S  + LKV  P   P         
Sbjct: 4909 GISFIDGLATFQISGARVENSGTYVCEARND-AGTASCSIELKVKEP---PTFIRELKPV 4964

Query: 762  HAAVGDLLELHCEALRGSPL-ILYRFFHEDVTLGNRSSPSGGASL-NLSLT---AEHSGN 816
                   +EL CE     P  + +   + ++    + + +   S+ NL +T      +G 
Sbjct: 4965 EVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGE 5024

Query: 817  YSCEADNGLGA 827
            Y C   N  G+
Sbjct: 5025 YQCIVSNEGGS 5035



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 170/820 (20%), Positives = 309/820 (37%), Gaps = 121/820 (14%)

Query: 75   LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS---------VFEGDSVVLRCRA 125
            +++ ++G + C+A  S  S       SS +LI+Q P S         V  G +V L+   
Sbjct: 4175 VDMNDAGNFTCRATNSVGSKD-----SSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTF 4229

Query: 126  KAEVTLNNTIYKNDNVLA-----FLNKR---TDFHIPHACLKDNGAYRCTGYKESCCPVS 177
            +    L    +K +  L      ++ K    +   +      D+G Y C     +     
Sbjct: 4230 QGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK--VSNVAGGV 4287

Query: 178  SNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGL 237
              +  + V+EP T       S     G+   L C+          P++  +F +D+ +  
Sbjct: 4288 ECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVT-----GTPPIKITWFANDREIKE 4342

Query: 238  GWSLSPNF-------QITAMWSKDSGFYWCKAATMPYS-------VISDSP---RSWIQV 280
                  +F       ++T +  +DSG Y C+A     S       ++ +SP   + +  +
Sbjct: 4343 SSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPI 4402

Query: 281  QIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340
            ++   + V+ L+        GT        +++++    R Y   +     S++      
Sbjct: 4403 EVLKEYDVMLLA-----EVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQI----- 4452

Query: 341  ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400
                    ++G Y C   N +G+    A  +++  P S  +  + S   L   G      
Sbjct: 4453 --LKFVAADAGEYQCRVTNEVGSSICSA-RVTLREPPSF-IKKIESTSSL--RGGTAAFQ 4506

Query: 401  CEAQRGSLPILYQFHHEGAALERRS------ANSAGGVAISFSLTAEHSGNYYCTADNGF 454
                +GSLPI   +  +   +           N+   + +S  +  +H G Y C A N  
Sbjct: 4507 ATL-KGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLS-GIEVKHDGKYVCQAKNDA 4564

Query: 455  GPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPL 514
            G QR  A+ LSV  P +   +T  +      +G   TL  +   G+ +I  +++ +   L
Sbjct: 4565 GIQRCSAL-LSVKEPAT---ITEEAVSIDVTQGDPATLQVKFS-GTKEITAKWFKDGQEL 4619

Query: 515  -----WSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ--RSEVVSLFVTVPVSRPI 567
                 +  S      +    S  +  SG Y     N  G    ++ +  L + +P   P 
Sbjct: 4620 TLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIP---PS 4676

Query: 568  LTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS----APSGGEASFNLS 623
             T ++ +  ++ G  ++L C    GS PI   ++ +D  + +S     +     A   +S
Sbjct: 4677 FTKKLKKMDSIKGSFIDLEC-IVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEIS 4735

Query: 624  -LTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
             L    SG Y+C A N   A H+     S  + V  P      P++Q V  +        
Sbjct: 4736 QLEGTDSGTYTCSATN--KAGHN---QCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKAL 4790

Query: 683  LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSL-----TTEHSGIYSCEADNGLEAQR 737
            + G++P+   ++ ++  L   +A S      + SL         SG Y C+  N +    
Sbjct: 4791 VGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTAT 4850

Query: 738  SEMVTLKVAVPVS-----RPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHE--D 790
            S+  TL V  P        PVL LR        G      C+ + G+P I   ++ +  +
Sbjct: 4851 SK-ATLFVKEPPQFIKKPSPVLVLRN-------GQSTTFECQ-ITGTPKIRVSWYLDGNE 4901

Query: 791  VTLGNRSSPS---GGASLNLS-LTAEHSGNYSCEADNGLG 826
            +T   +   S   G A+  +S    E+SG Y CEA N  G
Sbjct: 4902 ITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAG 4941



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 127/620 (20%), Positives = 211/620 (34%), Gaps = 130/620 (20%)

Query: 300  EGTKVTLHCETQEDSLRTLYRFYHEGVPL------RHKSVRCERGASISFSLTTENSGNY 353
            E  +  +  E  ED +     +Y +G+ +      RHK V   R   +  S T ++    
Sbjct: 3160 EKQRAVVEFEVNEDDVDA--HWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGE 3217

Query: 354  YCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------IFEGA---KVTLH 400
            Y      +  +   +V+L V  P    VL    P  +          +  G    K++ +
Sbjct: 3218 YTF----VAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWY 3273

Query: 401  CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460
             E Q  S     +F H+G               +      E +  Y C A N +G   + 
Sbjct: 3274 KEEQLLSTGFKCKFLHDGQEY----------TLLLIEAFPEDAAVYTCEAKNDYGVATTS 3323

Query: 461  AVSLSVTVP----------VSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHE 510
            A SLSV VP          V  P +     + +T EG      C V      +   +Y +
Sbjct: 3324 A-SLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVS--GTDLKVSWYSK 3380

Query: 511  DMPLWSSSTPSVGRVSFSFSLTEGHS-----GNYYCTADNGFGPQRSEVVSLFVTVPVS- 564
            D  +  S    + +   ++ L    +     G Y   A N  G Q S   +L +  P S 
Sbjct: 3381 DKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVG-QVSSTANLSLEAPESI 3439

Query: 565  ---------------RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF------YHE 603
                            P++  ++   +  +G L +  CE          WF      Y  
Sbjct: 3440 LHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES 3499

Query: 604  D-VTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILT 662
            D  ++ SS   S  E    L       G Y+C+A+N      S T +L+V      P   
Sbjct: 3500 DKCSIRSSKYISSLEI---LRTQVVDCGEYTCKASNEY-GSVSCTATLTV-TEAYPPTFL 3554

Query: 663  FRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNL------- 715
             R       VG   +  C      +P++   + +D   G   +PS      +        
Sbjct: 3555 SRPKSLTTFVGKAAKFICTVT--GTPVIETIWQKD---GAALSPSPNWRISDAENKHILE 3609

Query: 716  --SLTTEHSGIYSCEADN--GLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLEL 771
              +LT +  G+YSC+A N  G +  ++E++       + +P          +A+   + L
Sbjct: 3610 LSNLTIQDRGVYSCKASNKFGADICQAELII------IDKPHFIKELEPVQSAINKKVHL 3663

Query: 772  HCEALRGSPLIL--------------YRFFHEDVTLGNRSSPSGGASLNLSLT-AEHSGN 816
             C+      + +              Y+   ED            A+L + L   + SG 
Sbjct: 3664 ECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKI----------ATLEIPLAKLKDSGT 3713

Query: 817  YSCEADNGLGAQR-SETVTL 835
            Y C A N  G+   S TVT+
Sbjct: 3714 YVCTASNEAGSSSCSATVTV 3733



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 96/455 (21%), Positives = 162/455 (35%), Gaps = 62/455 (13%)

Query: 73   NILEVQESGEYRCQAQGS--PLSSPVHLDFSSASLILQAPLSVFE-----GDSVVLRCRA 125
            N +++ +SGEY C+A+ S   +S+   L      L       + +     G  VV  C  
Sbjct: 8021 NQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAI 8080

Query: 126  KAEVTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV- 176
                 ++ + YK+   L        +FL+     +I        G Y CT       P+ 
Sbjct: 8081 SGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATN----PIG 8136

Query: 177  -SSNTVKIQVQEPFTRPV--LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ 233
             +S++ ++ + E    P   +R +    + G      C           P++  + +D +
Sbjct: 8137 SASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHV-----TGTQPIKVSWAKDSR 8191

Query: 234  TLGLGWSL-------SPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASH 286
             +  G          S +  +  +   DSG Y C A      V  DS  + + ++     
Sbjct: 8192 EIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN---EVGKDSCTAQLNIKERLIP 8248

Query: 287  PVLTLS-PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSL 345
            P  T    E     EG    L          T+  +Y   + ++  S  CE    I+F  
Sbjct: 8249 PSFTKRLSETVEETEGNSFKLEGRVAGSQPITV-AWYKNNIEIQPTS-NCE----ITFKN 8302

Query: 346  TT----------ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395
             T           ++G Y C   N  G+    + S+ +  P   PV +       + EG 
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTS-SIVIKEPKKPPVFDQHLTPVTVSEGE 8361

Query: 396  KVTLHCEAQRGSLPILYQFHHEGAAL---ERRSANSAGGVAI--SFSLTAEHSGNYYCTA 450
             V L C  Q GS PI  Q+   G  +   +R S + A G A+     +    SG+Y C A
Sbjct: 8362 YVQLSCHVQ-GSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKA 8420

Query: 451  DNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTF 485
             N  G   +K+       P   P    ++ +   F
Sbjct: 8421 SNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLF 8455



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 39/167 (23%), Positives = 70/167 (41%), Gaps = 15/167 (8%)

Query: 672   VGDLLELHCEALRGSSPILYWF-YHEDVTLGKISAPSGGGASFNLSLTTEHS---GIYSC 727
             +G+  +L C+ +    P + W+ + +++   +    S  G +  L++ TE     G+Y+C
Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 30605

Query: 728   EADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFF 787
              A N +    +    L  A P   P   L+    + AVG  L LH   + G P+    +F
Sbjct: 30606 IATNEVGEVETSSKLLLQATPQFHPGYPLKEK-YYGAVGSTLRLHVMYI-GRPVPAMTWF 30663

Query: 788   H--------EDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLG 826
             H        E++T+ N    +     N+     H+G Y  +  N  G
Sbjct: 30664 HGQKLLQNSENITIENTEHYTHLVMKNVQ-RKTHAGKYKVQLSNVFG 30709



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 49/193 (25%), Positives = 74/193 (38%), Gaps = 18/193 (9%)

Query: 473 PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF--- 529
           P  T      +  EG+T T    +  G P     ++ +   + +S+ P V ++SFS    
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHIS-GFPVPEVSWFRDGQVISTSTLPGV-QISFSDGRA 63

Query: 530 -----SLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLE 584
                ++T+ +SG Y   A NG G Q +    L V    + P    R+       G  + 
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSG-QATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122

Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSS---SAPSGGEASFNLSLTA--EHSGNYSCEANNG 639
           L      G P  +  FY +   + SS        G+    L   A  E SG YS  A N 
Sbjct: 123 LQVRV-TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181

Query: 640 LVAQHSDTISLSV 652
            V + + T  L V
Sbjct: 182 -VGRATSTAELLV 193



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 11/109 (10%)

Query: 462  VSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS---- 517
            V   V +PV+ P L          EG +VTL C +  G P     +Y ED  + SS    
Sbjct: 932  VPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHIS-GYPSPTVTWYREDYQIESSIDFQ 990

Query: 518  --STPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVS 564
                  + R+    +  E  SG + C+A N  G   +   S ++ V VS
Sbjct: 991  ITFQSGIARLMIREAFAE-DSGRFTCSAVNEAG---TVSTSCYLAVQVS 1035



 Score = 33.5 bits (75), Expect = 1.00
 Identities = 28/103 (27%), Positives = 42/103 (40%), Gaps = 11/103 (10%)

Query: 559  VTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS-----SAP 613
            V +PV+ P L   +     + G+ + L C       P + W Y ED  + SS     +  
Sbjct: 936  VEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTW-YREDYQIESSIDFQITFQ 994

Query: 614  SGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656
            SG          AE SG ++C A N      + T+S S  + V
Sbjct: 995  SGIARLMIREAFAEDSGRFTCSAVN-----EAGTVSTSCYLAV 1032



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 34/116 (29%), Positives = 50/116 (43%), Gaps = 9/116 (7%)

Query: 439   TAEHSGNYYCTADNGFGPQRSKAVSLSVTV-PVSHPVLTLSSAEALTFEGATVTLHCEVQ 497
             T + SG Y  T  N   P   KAV ++V V     PV  L  ++ +T     V+      
Sbjct: 18669 TRDDSGKYSLTLVN---PAGEKAVFVNVRVLDTPGPVSDLKVSD-VTKTSCHVSWAPPEN 18724

Query: 498   RGSPQILYQFYHE---DMPLWSSSTPSVGRVSFSF-SLTEGHSGNYYCTADNGFGP 549
              G  Q+ +    +   D   WS+ TP V + SF   +L  G+   +  TA N +GP
Sbjct: 18725 DGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGP 18780



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 35/161 (21%), Positives = 63/161 (39%), Gaps = 19/161 (11%)

Query: 94   SPVHLDFSSASLILQAP-LSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL--------AF 144
            +PV +  +  +L+     ++V EG+SV L C      +   T Y+ D  +         F
Sbjct: 934  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993

Query: 145  LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISG 204
             +      I  A  +D+G + C+   E+    +S  + +QV E F +     +       
Sbjct: 994  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE------ 1047

Query: 205  NPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNF 245
                 T E +  +E  DV +      ++Q  G G   +P F
Sbjct: 1048 ---KFTTEEKRFVESRDVVMTDTSLTEEQA-GPGEPAAPYF 1084



 Score = 31.6 bits (70), Expect = 3.8
 Identities = 37/139 (26%), Positives = 51/139 (36%), Gaps = 17/139 (12%)

Query: 338 GASISFS----------LTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSP 387
           G  ISFS          +T  NSG Y   A NG G   S A  L V    + P       
Sbjct: 53  GVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTA-ELLVKAETAPPNFVQRLQ 111

Query: 388 EDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLT-----AEH 442
              + +G++V L         P++ +F+ +GA ++             +SL       E 
Sbjct: 112 SMTVRQGSQVRLQVRVTGIPTPVV-KFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPED 170

Query: 443 SGNYYCTADNGFGPQRSKA 461
           SG Y   A N  G   S A
Sbjct: 171 SGTYSVNATNSVGRATSTA 189



 Score = 31.6 bits (70), Expect = 3.8
 Identities = 27/119 (22%), Positives = 49/119 (41%), Gaps = 12/119 (10%)

Query: 99    DFSSASLILQAPLS--VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRT------- 149
             + S A   +  P S  + EG +V+  C    E +     +KN+  ++  +  +       
Sbjct: 33129 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNV 33188

Query: 150   -DFHIPHACLKDNGAY--RCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGN 205
                 I +A + D+G Y  +   ++  C   +S  V   V+EP    VLR S    + G+
Sbjct: 33189 YSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGS 33247



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 8/104 (7%)

Query: 635  EANNGLVAQHSDT--ISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692
            E  +G  A+ ++T  +   V +PV+ P L         + G+ + L C      SP + W
Sbjct: 917  EVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTW 976

Query: 693  FYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADN 731
             Y ED  +      +I+  SG           E SG ++C A N
Sbjct: 977  -YREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVN 1019



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 64/295 (21%), Positives = 99/295 (33%), Gaps = 31/295 (10%)

Query: 283   PASHPVLTLSPE---------KALNFEGTKVTLHCETQE-DSLRTLYRF---YHEGVPLR 329
             PAS PV+   P          + L+     VTL  E  E D  + +  +   Y +     
Sbjct: 30417 PASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSA 30476

Query: 330   HKSVRCERGASISFSL-----TTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH-PVLN 383
              K    ER     F++      TE     +   + GL      A+S+   +     P + 
Sbjct: 30477 WKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIR 30536

Query: 384   LSSPEDLIFEGAKVTLHCEAQRGSLPIL--YQFHHEGAALERRSANSAGGVAISFSLTAE 441
                 +     G    L C+     LP +  Y+F  E     +   +S G       +T E
Sbjct: 30537 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE 30596

Query: 442   HS--GNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRG 499
                 G Y C A N  G   + +  L    P  HP   L   +     G+T+ LH  +  G
Sbjct: 30597 QEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKE-KYYGAVGSTLRLHV-MYIG 30654

Query: 500   SPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLT------EGHSGNYYCTADNGFG 548
              P     ++H    L +S   ++        L       + H+G Y     N FG
Sbjct: 30655 RPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFG 30709


>gi|50511926 Fc fragment of IgG, low affinity IIb, receptor isoform
           3 [Homo sapiens]
          Length = 291

 Score =  112 bits (280), Expect = 2e-24
 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 8/198 (4%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  +L LAPV+G  A  P+ ++ L+P W  V Q + VTLTC+G         +W+H 
Sbjct: 28  MLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 87

Query: 61  YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116
             G  I   T  +        +SGEY CQ   + LS PVHL   S  L+LQ P L   EG
Sbjct: 88  --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 145

Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175
           +++VLRC + K +  +  T ++N     F     +F IP A    +G Y CTG       
Sbjct: 146 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 204

Query: 176 VSSNTVKIQVQEPFTRPV 193
            SS  V I VQ P + P+
Sbjct: 205 YSSKPVTITVQAPSSSPM 222



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 46/194 (23%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 283 PASHP--VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340
           PA+ P  VL L P+     +   VTL C           +++H G       +      S
Sbjct: 44  PAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPS 98

Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400
             F     +SG Y C       + P     LS  + +  P L          EG  + L 
Sbjct: 99  YRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLR 151

Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460
           C + +    +   F   G +  ++ + S    +I       HSG+Y+CT + G+    SK
Sbjct: 152 CHSWKDKPLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSK 208

Query: 461 AVSLSVTVPVSHPV 474
            V+++V  P S P+
Sbjct: 209 PVTITVQAPSSSPM 222



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 50/217 (23%), Positives = 83/217 (38%), Gaps = 23/217 (10%)

Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732
           D + L C       S  + WF++ ++       P+    S+        SG Y+C+    
Sbjct: 65  DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 116

Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
            +   S+ V L V        L L+ P      G+ + L C + +  PL+   FF     
Sbjct: 117 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 168

Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849
              +S     +  N S+      HSG+Y C  + G     S+ VT+ +   +++  G   
Sbjct: 169 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 225

Query: 850 TGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPA 886
             V  G+   A +AA   L+YC   R +      D A
Sbjct: 226 VAVVTGIAVAAIVAAVVALIYCRKKRISANPTNPDEA 262



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%)

Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440
           VL L      + +   VTL C           Q+ H G  +   +  S       F    
Sbjct: 51  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 105

Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500
             SG Y C            ++S  V + V    L L +      EG T+ L C   +  
Sbjct: 106 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 158

Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557
           P +   F+       +  +    R   +FS+ +    HSG+Y+CT + G+    S+ V++
Sbjct: 159 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 212

Query: 558 FVTVPVSRPI 567
            V  P S P+
Sbjct: 213 TVQAPSSSPM 222



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 18/174 (10%)

Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656
           + WF++ ++       P+  + S+        SG Y+C+     +   SD + L+V+   
Sbjct: 82  IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 129

Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716
               L  + P  +   G+ + L C + +    +   F+      GK    S    +F++ 
Sbjct: 130 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 184

Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLL 769
                HSG Y C  + G     S+ VT+ V  P S P+  + A  T  AV  ++
Sbjct: 185 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIV 238


>gi|50511930 Fc fragment of IgG, low affinity IIb, receptor isoform
           1 [Homo sapiens]
          Length = 310

 Score =  112 bits (280), Expect = 2e-24
 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 8/198 (4%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  +L LAPV+G  A  P+ ++ L+P W  V Q + VTLTC+G         +W+H 
Sbjct: 28  MLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 87

Query: 61  YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116
             G  I   T  +        +SGEY CQ   + LS PVHL   S  L+LQ P L   EG
Sbjct: 88  --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 145

Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175
           +++VLRC + K +  +  T ++N     F     +F IP A    +G Y CTG       
Sbjct: 146 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 204

Query: 176 VSSNTVKIQVQEPFTRPV 193
            SS  V I VQ P + P+
Sbjct: 205 YSSKPVTITVQAPSSSPM 222



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 46/194 (23%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 283 PASHP--VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340
           PA+ P  VL L P+     +   VTL C           +++H G       +      S
Sbjct: 44  PAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPS 98

Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400
             F     +SG Y C       + P     LS  + +  P L          EG  + L 
Sbjct: 99  YRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLR 151

Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460
           C + +    +   F   G +  ++ + S    +I       HSG+Y+CT + G+    SK
Sbjct: 152 CHSWKDKPLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSK 208

Query: 461 AVSLSVTVPVSHPV 474
            V+++V  P S P+
Sbjct: 209 PVTITVQAPSSSPM 222



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 47/202 (23%), Positives = 79/202 (39%), Gaps = 23/202 (11%)

Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732
           D + L C       S  + WF++ ++       P+    S+        SG Y+C+    
Sbjct: 65  DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 116

Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
            +   S+ V L V        L L+ P      G+ + L C + +  PL+   FF     
Sbjct: 117 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 168

Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849
              +S     +  N S+      HSG+Y C  + G     S+ VT+ +   +++  G   
Sbjct: 169 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 225

Query: 850 TGVAGGLLSIAGLAAGALLLYC 871
             V  G+   A +AA   L+YC
Sbjct: 226 VAVVTGIAVAAIVAAVVALIYC 247



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%)

Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440
           VL L      + +   VTL C           Q+ H G  +   +  S       F    
Sbjct: 51  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 105

Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500
             SG Y C            ++S  V + V    L L +      EG T+ L C   +  
Sbjct: 106 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 158

Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557
           P +   F+       +  +    R   +FS+ +    HSG+Y+CT + G+    S+ V++
Sbjct: 159 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 212

Query: 558 FVTVPVSRPI 567
            V  P S P+
Sbjct: 213 TVQAPSSSPM 222



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 43/191 (22%), Positives = 77/191 (40%), Gaps = 23/191 (12%)

Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656
           + WF++ ++       P+  + S+        SG Y+C+     +   SD + L+V+   
Sbjct: 82  IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 129

Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716
               L  + P  +   G+ + L C + +    +   F+      GK    S    +F++ 
Sbjct: 130 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 184

Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLE----- 770
                HSG Y C  + G     S+ VT+ V  P S P+  + A  T  AV  ++      
Sbjct: 185 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVAL 244

Query: 771 LHCEALRGSPL 781
           ++C   R S L
Sbjct: 245 IYCRKKRISAL 255


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  112 bits (279), Expect = 2e-24
 Identities = 205/866 (23%), Positives = 337/866 (38%), Gaps = 99/866 (11%)

Query: 21   PRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYH-----RYLGKEILRETPDNIL 75
            P P+I + P   TV  GER  LTC          T W       R      +R   +  L
Sbjct: 519  PPPVIQV-PNNVTVTPGERAVLTCLIISAVDYNLT-WQRNDRDVRLAEPARIRTLANLSL 576

Query: 76   EVQ-----ESGEYRCQ--AQGSPLSSPVHLDFSSASLILQAPL--SVFEGDSVVLRCRA- 125
            E++     ++GEY C   ++G   ++ V L       +   P   S   G  V + C A 
Sbjct: 577  ELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSAT 636

Query: 126  -----KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180
                 K   T+N+      +     +  T F I +A  KD G Y C     +     ++T
Sbjct: 637  GYPKPKIAWTVNDMFIVGSHRYRMTSDGTLF-IKNAAPKDAGIYGCLASNSAGTDKQNST 695

Query: 181  VKIQVQEPFTRPVLRASSFQPISGNPVTLTCET------QLSLERSDVPLR-FRFFRDDQ 233
            ++  ++ P  + ++  S      G+   + C+T      Q+   + D+ LR   F   D 
Sbjct: 696  LRY-IEAP--KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDP 752

Query: 234  TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293
             LGL        +I      D+G Y C A       I+++ R+  ++ +    P + +  
Sbjct: 753  LLGL-------LKIQETQDLDAGDYTCVA-------INEAGRATGKITLDVGSPPVFIQE 798

Query: 294  EKALNFE-GTKVTLHCETQEDSLRTLYRFYHEGVPL--RHKSV----RCERGASISFSLT 346
               ++ E G+ VTL C  Q     T+     + +P+  R  SV    +   GA    +L 
Sbjct: 799  PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLW 858

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406
              + G Y C A+N  G K     +++VT  V+ P++ +S     + EG ++TL C    G
Sbjct: 859  ASDKGTYICEAENQFG-KIQSETTVTVTGLVA-PLIGISPSVANVIEGQQLTLPCTLLAG 916

Query: 407  S-LPILYQFHHEGAALERR--SANSAGGVAISFSLTAEHSGNYYCTADNGFGP-QRSKAV 462
            + +P      +    L+    +  S G + I   +  +  G Y C A N  G   ++ +V
Sbjct: 917  NPIPERRWIKNSAMLLQNPYITVRSDGSLHIE-RVQLQDGGEYTCVASNVAGTNNKTTSV 975

Query: 463  SLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV 522
             + V   + H    LS     T EG  VTL C+        +      ++   SS+  S 
Sbjct: 976  VVHVLPTIQHGQQILS-----TIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSA 1030

Query: 523  GRVSFSFSLTEG--HSGNYYCTADNGFGPQRSEV-VSLFVTVPV---SRPILTLRVPRAQ 576
            G     + ++ G   SG Y CTA N  G  + +V ++++V   V    R +   +     
Sbjct: 1031 GADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS 1090

Query: 577  AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-----SGGEASFNLSLTAEHSGN 631
             + G+ + L CE     PPI+ W   ++  L S  +P       G      + T++ SG 
Sbjct: 1091 VLAGEEVTLPCEVKSLPPPIITW--AKETQLISPFSPRHTFLPSGSMKITETRTSD-SGM 1147

Query: 632  YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILY 691
            Y C A N +    +  + L+V VP   P +       +  VG  +++ C A     P++ 
Sbjct: 1148 YLCVATN-IAGNVTQAVKLNVHVP---PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVIT 1203

Query: 692  WFYHEDVTL--GKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPV 749
            W       L  G+    +  G       T   +GIY+C A N      +E +TL V  P 
Sbjct: 1204 WSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPP 1262

Query: 750  SRPVLTLRAPGT----HAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PS 800
            +  V  L  P             +E  C A +G+P    ++ H    L  R         
Sbjct: 1263 T--VEDLEPPYNTTFQERVANQRIEFPCPA-KGTPKPTIKWLHNGRELTGREPGISILED 1319

Query: 801  GGASLNLSLTAEHSGNYSCEADNGLG 826
            G   +  S+T   +G Y C A N  G
Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAG 1345



 Score =  102 bits (253), Expect = 2e-21
 Identities = 188/815 (23%), Positives = 316/815 (38%), Gaps = 101/815 (12%)

Query: 77   VQESGEYRCQAQGSPLS--SPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVTLN 132
            + + G Y C A  S  +  +    D S    ++Q P  ++V  G+  VL C   + V  N
Sbjct: 491  LSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYN 550

Query: 133  NTIYKNDNVLAFLNK-------RTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQV 185
             T  +ND  +                 +      D G Y C    E     +S  V + V
Sbjct: 551  LTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAAS--VFLTV 608

Query: 186  QEPFTRPVL-RASSFQPISGNPVTLTCET------QLSLERSDVPL----RFRFFRDDQT 234
            QEP    V+ +  SF    G+ V++ C        +++   +D+ +    R+R   D   
Sbjct: 609  QEPPKVTVMPKNQSFT--GGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTL 666

Query: 235  LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294
                        I     KD+G Y C A+    +   +S   +I+       P L +   
Sbjct: 667  F-----------IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEA------PKLMVVQS 709

Query: 295  KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKS---VRCERGASISFSLTTENSG 351
            + L   G    + C+T       + +++   + LR  +   +    G          ++G
Sbjct: 710  ELLVALGDITVMECKTSGIPPPQV-KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAG 768

Query: 352  NYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE-GAKVTLHCEAQRGSLPI 410
            +Y C A N  G    K     +T+ V  P + +  P D+  E G+ VTL C  Q    P 
Sbjct: 769  DYTCVAINEAGRATGK-----ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPT 823

Query: 411  LYQFHHEGAALERRSANSAG------GVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464
            +     +   +  R  + +       G     +L A   G Y C A+N FG  +S+  ++
Sbjct: 824  IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSE-TTV 882

Query: 465  SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS---STPS 521
            +VT  V+ P++ +S + A   EG  +TL C +  G+P    ++      L  +   +  S
Sbjct: 883  TVTGLVA-PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS 941

Query: 522  VGRVSFS-FSLTEGHSGNYYCTADNGFGPQR---SEVVSLFVTVPVSRPILTLRVPRAQA 577
             G +      L +G  G Y C A N  G      S VV +  T+   + IL+        
Sbjct: 942  DGSLHIERVQLQDG--GEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILS-------T 992

Query: 578  VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGE--ASFNLSLTAEHSGNYSCE 635
            + G  + L C+A     P + W    ++   SS+  S G   + + +S   E SG Y C 
Sbjct: 993  IEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCT 1052

Query: 636  ANNGLVAQHSDTISLSVIVPV-----SRPILTFRAPRAQAVVGDLLELHCEALRGSSPIL 690
            A N         + L+V V        R +   +      + G+ + L CE      PI+
Sbjct: 1053 ATN-TAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII 1111

Query: 691  YWFYHEDVTLGKISAPSGGGASFNLSLT---TEHSGIYSCEADNGLEAQRSEMVTLKVAV 747
             W   E   +   S       S ++ +T   T  SG+Y C A N +    ++ V L V V
Sbjct: 1112 TW-AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN-IAGNVTQAVKLNVHV 1169

Query: 748  PVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL-----GNRSSPSGG 802
            P   P +          VG  +++ C A +G+PL +  +     T+      + S+P G 
Sbjct: 1170 P---PKIQRGPKHLKVQVGQRVDIPCNA-QGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225

Query: 803  ASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYI 837
             S++   T   +G Y+C A N  G   +E +TL++
Sbjct: 1226 LSID-QATPSDAGIYTCVATNIAGTDETE-ITLHV 1258



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 209/867 (24%), Positives = 325/867 (37%), Gaps = 116/867 (13%)

Query: 28   QPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPD------------NIL 75
            +P   TV +  +VTL CK      P  T W       E L+ TP             N  
Sbjct: 3627 EPRDITVLRNRQVTLECKSDAVPPPVIT-WLRN---GERLQATPRVRILSGGRYLQINNA 3682

Query: 76   EVQESGEYRCQAQGSP----------LSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA 125
            ++ ++  Y C A              ++ P ++     SL+      +    S VL C A
Sbjct: 3683 DLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLV------ILLNKSTVLECIA 3736

Query: 126  KAEVTLNNTIYKNDNVLAFLNKRTDF------HIPHACLKDNGAYRCTGYKESCCPVSSN 179
            +   T   T  K+  VLA  + R         HI  A + D G Y C     +       
Sbjct: 3737 EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMA--TNAAGTDRR 3794

Query: 180  TVKIQVQEPFTRPVLRASSFQPISGN-PVTLTCETQLSLERSDVPLRFRFFR-------- 230
             + +QV  P         S  P   N  V +  +T L+ E + +P     +R        
Sbjct: 3795 RIDLQVHVP--------PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNV 3846

Query: 231  DDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290
            D          S +  I +    D+  Y C   T+      D     + VQ+P   P + 
Sbjct: 3847 DQNQNSYRLLSSGSLVIISPSVDDTATYEC---TVTNGAGDDKRTVDLTVQVP---PSIA 3900

Query: 291  LSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL--RHKSVRCERGASISFSLTTE 348
              P   L  +     + C        +++ +   G+ L  R    R     +I    T  
Sbjct: 3901 DEPTDFLVTKHAPAVITCTASGVPFPSIH-WTKNGIRLLPRGDGYRILSSGAIEILATQL 3959

Query: 349  N-SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
            N +G Y C A N  G+   + V+L V  P   PV+     E  +     + L CEA    
Sbjct: 3960 NHAGRYTCVARNAAGSA-HRHVTLHVHEP---PVIQPQPSELHVILNNPILLPCEATGTP 4015

Query: 408  LPILYQFHHEGAALERRSANSA----GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVS 463
             P +  +  EG  +     N A    GG+ IS ++  E +G Y C A N  G    K + 
Sbjct: 4016 SPFI-TWQKEGINVNTSGRNHAVLPSGGLQISRAVR-EDAGTYMCVAQNPAGTALGK-IK 4072

Query: 464  LSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV- 522
            L+V VP   PV++    E +      +TL CE   G P     ++ +   +  S    V 
Sbjct: 4073 LNVQVP---PVISPHLKEYVIAVDKPITLSCEAD-GLPPPDITWHKDGRAIVESIRQRVL 4128

Query: 523  --GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVG 580
              G +  +F +  G +G+Y C A N  G   S    L V VP       +R       V 
Sbjct: 4129 SSGSLQIAF-VQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPR-----IRSTEGHYTVN 4181

Query: 581  DLLE--LHCEAPRGSPPILYWFYHEDVT---LGSSSAPSGGEASFNLSLTAEHSGNYSCE 635
            +  +  L C A     P + W     +    LG  +A   GE     ++  E SG Y+C 
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILE-NVVLEDSGFYTCV 4240

Query: 636  ANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYH 695
            ANN    + + T+SL+V V    P  T          G+ L L C+A     P L W ++
Sbjct: 4241 ANNA-AGEDTHTVSLTVHV---LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFN 4296

Query: 696  EDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSR---P 752
             ++      + +G        ++ E SG Y C A+N +   ++         PV +   P
Sbjct: 4297 NNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYP 4356

Query: 753  VLTLRAPGTHAAVGDLLELHCEALRG--SPLILYRFFHEDVTLGNRSSPSGGASLNLSLT 810
               +   G +A       L+CE ++G  +P I +     D+ + +R    G  SL +  T
Sbjct: 4357 SNWIEPLGGNAI------LNCE-VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGT 4409

Query: 811  A-EHSGNYSCEADNGLG-AQRSETVTL 835
              E +G+Y+C A N  G  +RS ++TL
Sbjct: 4410 VNEDAGDYTCVATNEAGVVERSMSLTL 4436



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 190/869 (21%), Positives = 329/869 (37%), Gaps = 104/869 (11%)

Query: 23   PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR---YLGKEILRETPDNIL---- 75
            P+I + P    V +G+++TL C         + +W       L    +    D  L    
Sbjct: 890  PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIER 949

Query: 76   -EVQESGEYRCQAQGSPLSSPVHLDFSSASLIL---------QAPLSVFEGDSVVLRCRA 125
             ++Q+ GEY C A     S+    +  + S+++         Q  LS  EG  V L C+A
Sbjct: 950  VQLQDGGEYTCVA-----SNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKA 1004

Query: 126  KAEVTLNNTIYKNDNVLAFLNKR------TDFHIPHACLKDNGAYRCTGYKESCCPVSSN 179
                  +    K   +++  + +         ++     +++G Y CT    +       
Sbjct: 1005 SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKV 1064

Query: 180  TVKIQVQEPFTRPVLRASSFQPI-----SGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
             + + V+          S  +P+     +G  VTL CE      +S  P    + ++ Q 
Sbjct: 1065 QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV-----KSLPPPIITWAKETQL 1119

Query: 235  LG-----LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVL 289
            +        +  S + +IT   + DSG Y C A  +  +V   +    + V +P   P +
Sbjct: 1120 ISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV---TQAVKLNVHVP---PKI 1173

Query: 290  TLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG-----VPLRHKSVRCERGASISFS 344
               P+      G +V + C  Q   L  +   + +G     V   H     +   SI   
Sbjct: 1174 QRGPKHLKVQVGQRVDIPCNAQGTPLPVI--TWSKGGSTMLVDGEHHVSNPDGTLSID-Q 1230

Query: 345  LTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE----GAKVTLH 400
             T  ++G Y C A N  G   ++ ++L V  P +  V +L  P +  F+      ++   
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPT--VEDLEPPYNTTFQERVANQRIEFP 1287

Query: 401  CEAQRGSLPILYQFHHEGAALERR----SANSAGGVAISFSLTAEHSGNYYCTADNGFGP 456
            C A+    P + ++ H G  L  R    S    G + +  S+T   +G Y C A N  G 
Sbjct: 1288 CPAKGTPKPTI-KWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346

Query: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALT----FEGATVTLHCEVQRGSPQILYQFYHEDM 512
               K  +L V VP   PV  +   E +T           L CEV+ G+P  +  +Y +++
Sbjct: 1347 TERK-YNLKVHVP---PV--IKDKEQVTNVSVLLNQLTNLFCEVE-GTPSPIIMWYKDNV 1399

Query: 513  PLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILT 569
             +  SST      G++   F  T   +G Y C A N  G  + +  ++ V VP +  I+ 
Sbjct: 1400 QVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ-KYFNIDVLVPPT--IIG 1456

Query: 570  LRVPRAQAVVGDL-LELHCEAPRGSP-PILYWFYH-EDVTLGSSSAP--SGGEASFNLSL 624
               P   +VV +  + L C+  +G+P P ++WF   + + LG  +      G+     + 
Sbjct: 1457 TNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNA 1515

Query: 625  TAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALR 684
                 G Y C  +N    Q  D I L++ +P S             ++  L++L CE   
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKD-IKLTIYIPPSIKGGNVTTD-ISVLINSLIKLECETRG 1573

Query: 685  GSSPILYWFYHEDVTLGKISA--PSGGGASFNLSLTTEHSGIYSCEADN-GLEAQRSEMV 741
               P + W+      +    A     G            S  Y+C   N    A++S  V
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633

Query: 742  TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL---GNRSS 798
             + V   +   + T         +   L L C+A  G+P  +  +  + V +    N   
Sbjct: 1634 DVYVPPMIEGNLAT--PLNKQVVIAHSLTLECKA-AGNPSPILTWLKDGVPVKANDNIRI 1690

Query: 799  PSGGASLNLSLTAE-HSGNYSCEADNGLG 826
             +GG  L +    E   G Y C A +  G
Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAG 1719



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 182/818 (22%), Positives = 301/818 (36%), Gaps = 95/818 (11%)

Query: 78   QESGEYRCQAQGSP------------LSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA 125
            +ESGEY C A  +             +   V  D    S      +SV  G+ V L C  
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103

Query: 126  KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLK-------DNGAYRCTGYKESCCPVSS 178
            K+      T  K   +++  + R  F +P   +K       D+G Y C     +     +
Sbjct: 1104 KSLPPPIITWAKETQLISPFSPRHTF-LPSGSMKITETRTSDSGMYLCVA--TNIAGNVT 1160

Query: 179  NTVKIQVQEPFTRPVLRASSFQPIS-GNPVTLTCETQLSLERSDVPLRFRFFRDDQTL-- 235
              VK+ V  P    + R      +  G  V + C  Q     + +P+   + +   T+  
Sbjct: 1161 QAVKLNVHVP--PKIQRGPKHLKVQVGQRVDIPCNAQ----GTPLPV-ITWSKGGSTMLV 1213

Query: 236  -GLGWSLSPN--FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLS 292
             G     +P+    I      D+G Y C A  +  +   D     + VQ P +  V  L 
Sbjct: 1214 DGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT---DETEITLHVQEPPT--VEDLE 1268

Query: 293  PEKALNFE----GTKVTLHCETQEDSLRTLYRFYHEGVPLRHK----SVRCERGASISFS 344
            P     F+      ++   C  +     T+ ++ H G  L  +    S+  +    +  S
Sbjct: 1269 PPYNTTFQERVANQRIEFPCPAKGTPKPTI-KWLHNGRELTGREPGISILEDGTLLVIAS 1327

Query: 345  LTTENSGNYYCTADNGLGAKPSKAVSLSVTVPV----SHPVLNLSSPEDLIFEGAKVTLH 400
            +T  ++G Y C A N  G    K  +L V VP        V N+S     +       L 
Sbjct: 1328 VTPYDNGEYICVAVNEAGTTERK-YNLKVHVPPVIKDKEQVTNVS-----VLLNQLTNLF 1381

Query: 401  CEAQRGSLPILYQFHHEGAALERRSANSA--GGVAISFSLTAEHSGNYYCTADNGFGPQR 458
            CE +    PI+  +       E  +  +   G +   F  T E +G Y C A N  G  +
Sbjct: 1382 CEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ 1441

Query: 459  SKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS 518
             K  ++ V VP +  + T    E        V L C+V +G+P     ++ +  PL+   
Sbjct: 1442 -KYFNIDVLVPPTI-IGTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPLFLGD 1498

Query: 519  TPSV-----GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572
             P+V     G+V    +      G Y CT  N  G Q  ++ +++++   +    +T  +
Sbjct: 1499 -PNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDI 1557

Query: 573  PRAQAVVGDLLELHCEAPRGSP-PILYWFYHEDVTLGSSSAP--SGGEASFNLSLTAEHS 629
                 ++  L++L CE  RG P P + W+      + SS A     G+           S
Sbjct: 1558 ---SVLINSLIKLECET-RGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDS 1613

Query: 630  GNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPI 689
              Y+C   N +      +  + V VP             Q V+   L L C+A    SPI
Sbjct: 1614 ATYTCHVAN-VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI 1672

Query: 690  LYWFYHEDVTL---GKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746
            L W   + V +     I   +GG     +S      G Y C A   +  ++     + V 
Sbjct: 1673 LTWL-KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA-TSVAGEKEIKYEVDVL 1730

Query: 747  VPVSRPVLTLRAPGTH--AAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS----PS 800
            VP   P +      ++    V +LLEL C  + GSP     +  +   +  R       +
Sbjct: 1731 VP---PAIEGGDETSYFIVMVNNLLELDCH-VTGSPPPTIMWLKDGQLIDERDGFKILLN 1786

Query: 801  GGASLNLSLTAEHSGNYSCEADNGLGAQRSE-TVTLYI 837
            G   +       ++G Y C A N  G  + E  VT+++
Sbjct: 1787 GRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHV 1824



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 168/822 (20%), Positives = 306/822 (37%), Gaps = 94/822 (11%)

Query: 65   EILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP----------LSVF 114
            ++ R TP+      ++G Y C+A     +S  + +      +L  P          +SV 
Sbjct: 1417 KLFRATPE------DAGRYSCKAINIAGTSQKYFNID----VLVPPTIIGTNFPNEVSVV 1466

Query: 115  EGDSVVLRCRAKAEVTLN-------NTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCT 167
                V L C+ K     +         ++  D  +  L++    H+ +A   D G Y+CT
Sbjct: 1467 LNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCT 1526

Query: 168  GYKESCCPVSSNTVKIQVQEPFTRPVLRASS----FQPISGNPVTLTCETQLSLERSDVP 223
                +     +  +K+ +  P   P ++  +       +  + + L CET+       +P
Sbjct: 1527 --VSNAAGKQAKDIKLTIYIP---PSIKGGNVTTDISVLINSLIKLECETR------GLP 1575

Query: 224  L-RFRFFRDDQTL-----GLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW 277
            +    +++D Q +      L         I      DS  Y C  A    +V   + +S+
Sbjct: 1576 MPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVA----NVAGTAEKSF 1631

Query: 278  -IQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRC 335
             + V +P        +P          +TL C+   +    L  +  +GVP++ + ++R 
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL-TWLKDGVPVKANDNIRI 1690

Query: 336  ERGASISFSLTTE--NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPED--LI 391
            E G      ++ +  + G Y C A +  G K  K   + V VP   P +         ++
Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK-YEVDVLVP---PAIEGGDETSYFIV 1746

Query: 392  FEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA---GGVAISFSLTAEHSGNYYC 448
                 + L C    GS P    +  +G  ++ R        G   +       ++G Y C
Sbjct: 1747 MVNNLLELDCHVT-GSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRC 1805

Query: 449  TADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFY 508
             A N  G  + +     VTV V   + +   +E +  +   V L C +  G P     + 
Sbjct: 1806 MAANTAGDHKKE---FEVTVHVPPTIKSSGLSERVVVKYKPVALQC-IANGIPNPSITWL 1861

Query: 509  HEDMPLWSSS----TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVS 564
             +D P+ ++       S GRV          +G Y C A N  G +  + + L V  P S
Sbjct: 1862 KDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAG-ETQQHIQLHVHEPPS 1920

Query: 565  RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP--SGGEASFNL 622
                  ++     +V + ++L C+A     P++ W+    +  GS+S    + G+     
Sbjct: 1921 LEDAG-KMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIE 1979

Query: 623  SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
            S     +G Y C A N   A     +  S+ V V+ P ++        VV + + L CEA
Sbjct: 1980 SAQISDAGIYKCVAINSAGATE---LFYSLQVHVA-PSISGSNNMVAVVVNNPVRLECEA 2035

Query: 683  LRGSSPILYWFYHEDVT---LGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSE 739
                +P L W             +   SGG      S     +G Y+C A N    ++  
Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNA-AGEKQR 2094

Query: 740  MVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHC--EALRGSPLILYRFFHEDVTLGNRS 797
             + L+V VP   P +          +   +EL C  +A+    L   +  H  +     S
Sbjct: 2095 DIDLRVYVP---PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLS 2151

Query: 798  SPSGGASLNL-SLTAEHSGNYSCEADNGLG-AQRSETVTLYI 837
                 + L +     + +G Y+CEA N  G  +++  V +++
Sbjct: 2152 ISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWV 2193



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 144/643 (22%), Positives = 240/643 (37%), Gaps = 56/643 (8%)

Query: 222  VPLRFRFFRDDQTLG----LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW 277
            +P    F R+  TLG    L  S S N  I  +   D GFY C A +   S  +   +++
Sbjct: 457  LPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVS---SAGTGRAQTF 513

Query: 278  IQVQIPASHPVLTLSPEKALNFEGTKVTLHC--ETQEDSLRTLYRFYHEGVPLRHKSVRC 335
              V  P   P +   P       G +  L C   +  D   T  R   +        +R 
Sbjct: 514  FDVSEP---PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRT 570

Query: 336  ERGASISF-SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEG 394
                S+   S+   ++G Y+C   +  G   + +V L+V  P   P + +         G
Sbjct: 571  LANLSLELKSVKFNDAGEYHCMVSSE-GGSSAASVFLTVQEP---PKVTVMPKNQSFTGG 626

Query: 395  AKVTLHCEAQRGSLP-ILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNG 453
            ++V++ C A     P I +  +        R   ++ G     +   + +G Y C A N 
Sbjct: 627  SEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNS 686

Query: 454  FGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP 513
             G  +      S    +  P L +  +E L   G    + C+   G P    +++  D+ 
Sbjct: 687  AGTDKQN----STLRYIEAPKLMVVQSELLVALGDITVMECKTS-GIPPPQVKWFKGDLE 741

Query: 514  LWSSS----TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILT 569
            L  S+     P +G +       +  +G+Y C A N  G    +     +T+ V  P + 
Sbjct: 742  LRPSTFLIIDPLLGLLKIQ-ETQDLDAGDYTCVAINEAGRATGK-----ITLDVGSPPVF 795

Query: 570  LRVPRAQAV-VGDLLELHCEAPRGSPPILYW-------FYHEDVTLGSSSAPSGGEASFN 621
            ++ P   ++ +G  + L C       P + W        +    ++ S S    G A F 
Sbjct: 796  IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG-ALFI 854

Query: 622  LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681
            L+L A   G Y CEA N      S+T     +  +  P++      A  + G  L L C 
Sbjct: 855  LNLWASDKGTYICEAENQFGKIQSET--TVTVTGLVAPLIGISPSVANVIEGQQLTLPCT 912

Query: 682  ALRGSS-PILYWFYHEDVTLGK--ISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738
             L G+  P   W  +  + L    I+  S G       +  +  G Y+C A N      +
Sbjct: 913  LLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIE-RVQLQDGGEYTCVASN---VAGT 968

Query: 739  EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEAL-RGSPLILYRFFHEDVTLGNRS 797
               T  V V V  P +           G  + L C+A     P +++    E ++  +  
Sbjct: 969  NNKTTSVVVHV-LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAK 1027

Query: 798  SPSG--GASLNLSLTAEHSGNYSCEADNGLG-AQRSETVTLYI 837
              +G  G+   +S   E SG Y C A N  G A+R   +T+Y+
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYV 1070



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 179/784 (22%), Positives = 292/784 (37%), Gaps = 92/784 (11%)

Query: 113  VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRC 166
            V  G S+ L C  +       T  K+ + L        L++     + +  + D G Y C
Sbjct: 2304 VTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVC 2363

Query: 167  TGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-R 225
                 +        + +              +   +  N V+LTCE       S +PL  
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA------SGIPLPS 2417

Query: 226  FRFFRDDQTLGLGWS---LSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWIQV 280
              +F+D   + L  S   LS    +  M +  +D+G Y C       +   +     + V
Sbjct: 2418 ITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRN---AAGEERKIFGLSV 2474

Query: 281  QIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR----HKSVRCE 336
             +P  H V   + E     E   VTL CE   + +  +  ++ +G PL+    H  +   
Sbjct: 2475 LVPP-HIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEI-TWHKDGQPLQEDEAHHIISGG 2532

Query: 337  RGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTV-PVSHPVLNLSSPEDL-IFEG 394
            R   I+ ++   ++G Y C A +  G K S++ SL+V V P    V +  +PED+ +   
Sbjct: 2533 RFLQIT-NVQVPHTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590

Query: 395  AKVTLHCEAQRGSLPILYQFHHEGAALE--RRSANSAGGVAISF-SLTAEHSGNYYCTAD 451
            +  +L CEA     P    +  +G  LE  R      GG  +   +   +++G Y C A 
Sbjct: 2591 SPTSLVCEAYSYP-PATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVAT 2649

Query: 452  NGFGPQRSKAVSLSVTVPVSHPVLT--------LSSAEALTFEGATVTLHCEVQRGSPQI 503
            N  G +  K   + V +P   P++         LS  E       T+TL CE     P  
Sbjct: 2650 NEAG-EMIKHYEVKVYIP---PIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY-AIPSA 2704

Query: 504  LYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEVVSLFVT 560
               +Y +  PL S    ++     +  + E     +G Y C A N  G    +   + + 
Sbjct: 2705 SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDF-DVNIQ 2763

Query: 561  VPVSRPIL--------TLRVPRAQ-AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS 611
            VP S   L        T R   A+  ++ + + L+CE     PP L W Y +   L SS 
Sbjct: 2764 VPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW-YKDGHPLTSSD 2822

Query: 612  AP---SGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRA 668
                  GG          E +G Y+C A N    + S    + V+VP          P  
Sbjct: 2823 KVLILPGGRVLQIPRAKVEDAGRYTCVAVNE-AGEDSLQYDVRVLVPPIIKGANSDLPEE 2881

Query: 669  QAVVG------DLLELHCEALRGS-----SPILYWFYHEDVTLGKISAPSGGGASFNLSL 717
              V+       + L     A R S      P+L   +H+ ++ G+I          N  +
Sbjct: 2882 VTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRIL------QILNTQI 2935

Query: 718  TTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALR 777
            T    G Y C A+N       +   L V VP S  V+  ++      V + + L CE   
Sbjct: 2936 T--DIGRYVCVAEN-TAGSAKKYFNLNVHVPPS--VIGPKSENLTVVVNNFISLTCEVSG 2990

Query: 778  GSPLILYRFFHEDVTLGNRSS---PSGGASLNLSLTAEHSGNYSCEADNGLGAQRSE-TV 833
              P  L    +E     N ++   P G     +       G Y+C A N  G  + + ++
Sbjct: 2991 FPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSL 3050

Query: 834  TLYI 837
            T+Y+
Sbjct: 3051 TVYV 3054



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 157/707 (22%), Positives = 260/707 (36%), Gaps = 86/707 (12%)

Query: 202  ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSL-----SPNFQITAMWSKDSG 256
            I  +P +L CE       S  P    +F+D   L    ++         QI      ++G
Sbjct: 2588 ILNSPTSLVCEAY-----SYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAG 2642

Query: 257  FYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT--------LSPEKALNFEGTKVTLHC 308
             Y C A      +I       ++V IP   P++         LSP++        +TL C
Sbjct: 2643 RYSCVATNEAGEMIKHYE---VKVYIP---PIINKGDLWGPGLSPKEVKIKVNNTLTLEC 2696

Query: 309  ETQEDSLRTLYRFYHEGVPLR---HKSVRCERGASISFSLTTENSGNYYCTADNGLGAKP 365
            E       +L  +Y +G PL+   H ++               ++G Y C A N +  + 
Sbjct: 2697 EAYAIPSASL-SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASN-IAGED 2754

Query: 366  SKAVSLSVTVPVSHPVL----------NLSSPEDLIFEGAKVTLHCEAQRGSLPIL--YQ 413
                 +++ VP S   L               +D+I     ++L+CE      P L  Y+
Sbjct: 2755 ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP-ISLYCETNAAPPPTLTWYK 2813

Query: 414  FHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHP 473
              H   + ++      G V        E +G Y C A N  G + S    + V VP   P
Sbjct: 2814 DGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG-EDSLQYDVRVLVP---P 2869

Query: 474  VLTLSSA----EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTP---SVGRVS 526
            ++  +++    E       +  + C +  GSP     +  +  PL         S GR+ 
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIEC-LSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRIL 2928

Query: 527  FSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELH 586
               +      G Y C A+N  G  + +  +L V VP S  ++  +      VV + + L 
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAK-KYFNLNVHVPPS--VIGPKSENLTVVVNNFISLT 2985

Query: 587  CEAPRGSPPILYWFYHED-VTLGSSS-APSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644
            CE     PP L W  +E  + L +++    GG     +       G Y+C A N    + 
Sbjct: 2986 CEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAIN-QAGES 3044

Query: 645  SDTISLSVIVPVSRPILTFRAPRAQAVV----GDLLELHCEALRGSSPILYWFYHEDVTL 700
                SL+V VP   P +      + +VV    G  + L CE+     P++ W+ +  +  
Sbjct: 3045 KKKFSLTVYVP---PSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMIT 3101

Query: 701  GK--ISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRA 758
                +   + G            +G Y C A N +  +  +   L V VP S     +  
Sbjct: 3102 ESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAGRDDKNFHLNVYVPPS-----IEG 3155

Query: 759  PGTHAAVGDL---LELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLT 810
            P     V  +   + L C+A  G P     +      + N  S      SGG+ L ++ +
Sbjct: 3156 PEREVIVETISNPVTLTCDA-TGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARS 3214

Query: 811  A-EHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSGPFATGVAGG 855
                SGNY+C A N  G AQ+   +++ +    A    P    V  G
Sbjct: 3215 QHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLG 3261



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 148/589 (25%), Positives = 231/589 (39%), Gaps = 60/589 (10%)

Query: 40   VTLTCKGFRFYSPQKTKWYHRYL----GKEILRETPDNILEVQ--ESGEYRCQAQGSPLS 93
            +T T  G  F S   TK   R L    G  IL      IL  Q   +G Y C A+ +  S
Sbjct: 3916 ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGS 3975

Query: 94   SPVH--LDFSSASLILQAP--LSVFEGDSVVLRCRA----------KAEVTLNNTIYKND 139
            +  H  L      +I   P  L V   + ++L C A          + E    NT  +N 
Sbjct: 3976 AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNH 4035

Query: 140  NVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSF 199
             VL          I  A  +D G Y C     +   +    + +QV  P   P L+   +
Sbjct: 4036 AVLP----SGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVP-PVISPHLK--EY 4088

Query: 200  QPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYW 259
                  P+TL+CE    L   D+          +++      S + QI  +   D+G Y 
Sbjct: 4089 VIAVDKPITLSCEAD-GLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYT 4147

Query: 260  CKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRT-L 318
            C AA +  S    S  + + V +P    + +      +N E ++  L C    D + T  
Sbjct: 4148 CMAANVAGS---SSTSTKLTVHVPPR--IRSTEGHYTVN-ENSQAILPCVA--DGIPTPA 4199

Query: 319  YRFYHEGVPLRH---KSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTV 375
              +  + V L +   K      G  I  ++  E+SG Y C A+N  G + +  VSL+V V
Sbjct: 4200 INWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVHV 4258

Query: 376  PVSHPVLNLSSPEDL-IFEGAKVTLHCEAQRGSLPIL-YQFHHEGAALERRSANSAGGVA 433
              +   L    P D+ + +G ++ L C+A    LP L + F++        S N    + 
Sbjct: 4259 LPTFTEL----PGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELV 4314

Query: 434  ISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLH 493
            I   ++ E SG Y CTA+N  G  ++         PV       +  E L   G    L+
Sbjct: 4315 IE-RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL---GGNAILN 4370

Query: 494  CEVQRGSPQILYQFYHEDMPLW-SSSTPSVGRVSFS-FSLTEGHSGNYYCTADNGFGP-Q 550
            CEV +G P    Q+  + + +  S     +G  S + +      +G+Y C A N  G  +
Sbjct: 4371 CEV-KGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE 4429

Query: 551  RSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYW 599
            RS  ++L      S PI+TL         G  + L+C+A     P + W
Sbjct: 4430 RSMSLTL-----QSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 129/555 (23%), Positives = 223/555 (40%), Gaps = 64/555 (11%)

Query: 161  NGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRA--SSFQPISGNPVTLTCETQLSLE 218
            N A R T    +    +   V + V EP   PV++   S    I  NP+ L CE      
Sbjct: 3960 NHAGRYTCVARNAAGSAHRHVTLHVHEP---PVIQPQPSELHVILNNPILLPCEA----- 4011

Query: 219  RSDVPLRFRFFRDD----QTLGLGWSLSPN--FQITAMWSKDSGFYWCKAATMPYSVISD 272
             +  P  F  ++ +     T G   ++ P+   QI+    +D+G Y C A     + +  
Sbjct: 4012 -TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG- 4069

Query: 273  SPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKS 332
              +  + VQ+P   PV++   ++ +      +TL CE   D L      +H+      +S
Sbjct: 4070 --KIKLNVQVP---PVISPHLKEYVIAVDKPITLSCEA--DGLPPPDITWHKDGRAIVES 4122

Query: 333  VRCERGASISFSLT---TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPED 389
            +R    +S S  +      ++G+Y C A N  G+  S +  L+V VP   P +  +    
Sbjct: 4123 IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVP---PRIRSTEGHY 4178

Query: 390  LIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAG-------GVAISFSLTAEH 442
             + E ++  L C A     P +  +  +   L    AN  G       G  I  ++  E 
Sbjct: 4179 TVNENSQAILPCVADGIPTPAI-NWKKDNVLL----ANLLGKYTAEPYGELILENVVLED 4233

Query: 443  SGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQR-GSP 501
            SG Y C A+N  G + +  VSL+V V    P  T    +    +G  + L C+      P
Sbjct: 4234 SGFYTCVANNAAG-EDTHTVSLTVHVL---PTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289

Query: 502  QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTV 561
            ++ + F +  +P    S      +     +++  SG Y CTA+N  G  ++ +  ++V  
Sbjct: 4290 KLTWTFNNNIIPAHFDSVNGHSELVIE-RVSKEDSGTYVCTAENSVGFVKA-IGFVYVKE 4347

Query: 562  PVSRPILTLRVPR--AQAVVGDLLELHCEAPRGSPPILYWFYHE-DVTLGSSSAPSGGEA 618
            P   P+     P    + + G+ + L+CE      P + W     D+ +       G  +
Sbjct: 4348 P---PVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS 4403

Query: 619  SFNLSLTAEHSGNYSCEANNGL-VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLE 677
                    E +G+Y+C A N   V + S +++L      S PI+T          G  + 
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQ-----SPPIITLEPVETVINAGGKII 4458

Query: 678  LHCEALRGSSPILYW 692
            L+C+A     P + W
Sbjct: 4459 LNCQATGEPQPTITW 4473



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 185/817 (22%), Positives = 296/817 (36%), Gaps = 112/817 (13%)

Query: 76   EVQESGEYRCQAQGSPLSS-----------PVHLDFSSASLILQAPLSVFEGDSVVLRCR 124
            +V + GEY C A      S           P   D  S SL +   ++V EG SV L C 
Sbjct: 3026 KVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV---VNVREGTSVSLECE 3082

Query: 125  AKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSS 178
            + A      T YKN  ++        L      HI  A + D G Y C     +     +
Sbjct: 3083 SNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKN 3142

Query: 179  NTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLG 238
              + + V      P  R    + IS NPVTLTC+          P    + ++ + +   
Sbjct: 3143 FHLNVYVPPSIEGPE-REVIVETIS-NPVTLTCDA-----TGIPPPTIAWLKNHKRIENS 3195

Query: 239  WSL-------SPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQVQIPAS 285
             SL           QI      DSG Y C A+ M       Y +    P S    +IP+ 
Sbjct: 3196 DSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD 3255

Query: 286  HPVLTLSPEKALNFEGTKVTLHCETQEDSLRT-LYRFYHEGVPLRHKSVRCER----GAS 340
              VL           G  V L C    + + T L ++  +G P+        R    G++
Sbjct: 3256 VSVLL----------GENVELVCNA--NGIPTPLIQWLKDGKPIASGETERIRVSANGST 3303

Query: 341  IS-FSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399
            ++ +   T ++G Y C A N  G +  +  +L+V V  +       + + +      + +
Sbjct: 3304 LNIYGALTSDTGKYTCVATNPAG-EEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINI 3362

Query: 400  HCEAQRGSLPILYQFHHEGAALERRS---ANSAGGVAISFSLTAEHSGNYYCTADNGFGP 456
             C A  G+ P    +   G  L   S     +AG V             Y C A N  G 
Sbjct: 3363 ECRA-TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV 3421

Query: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516
              +K  +L V  P +    ++ + E    +G++ ++ C +  G+P     +  +  PL  
Sbjct: 3422 D-NKHYNLQVFAPPNMD-NSMGTEEITVLKGSSTSMAC-ITDGTPAPSMAWLRDGQPLGL 3478

Query: 517  SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEVVSLFVTVPVSRPIL--TLR 571
             +  +V        L +     SG Y C A N  G    EV   F+   +  P +  +  
Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG----EVSKHFILKVLEPPHINGSEE 3534

Query: 572  VPRAQAVVGDLLELHCEAPRGSPPILYWF--------YHEDVTLGSSSAPSGGEASFNLS 623
                  +V + LEL C A     P + W           +  TLG      GGE     +
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLG------GGEVLRIST 3588

Query: 624  LTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD-LLELHCEA 682
               E +G Y+C A++       D     V V V   I     PR   V+ +  + L C++
Sbjct: 3589 AQVEDTGRYTCLASS---PAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKS 3645

Query: 683  LRGSSPILYWFYHED--VTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740
                 P++ W  + +      ++   SGG      +     +  Y+C A N +  + +  
Sbjct: 3646 DAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTRE 3704

Query: 741  VTLKVAVPVS-----RPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGN 795
              L V VP +     + ++ L    T      +LE   E +  +P I +R     V  GN
Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKST------VLECIAEGV-PTPRITWR-KDGAVLAGN 3756

Query: 796  RSSPSGGASLNLSLTAEH---SGNYSCEADNGLGAQR 829
             +  S   +  L + + H   +G Y C A N  G  R
Sbjct: 3757 HARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 120/508 (23%), Positives = 190/508 (37%), Gaps = 42/508 (8%)

Query: 344  SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEA 403
            S    ++G Y C A N  GA     +  S+ V V+ P ++ S+    +     V L CEA
Sbjct: 1980 SAQISDAGIYKCVAINSAGATE---LFYSLQVHVA-PSISGSNNMVAVVVNNPVRLECEA 2035

Query: 404  QRGSLPILYQFHHEGAALERRSAN----SAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459
            +    P L  +  +G+ +   S      S G +    S     +G Y C A N  G ++ 
Sbjct: 2036 RGIPAPSL-TWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG-EKQ 2093

Query: 460  KAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSST 519
            + + L V VP   P +              V L C+     P  L  +  +  PL     
Sbjct: 2094 RDIDLRVYVP---PNIMGEEQNVSVLISQAVELLCQSDAIPPPTL-TWLKDGHPLLKKPG 2149

Query: 520  PSVGRVSFSFSLTEGH---SGNYYCTADNGFGP-QRSEVVSLFVTVPVSRPILTLRVPRA 575
             S+        + +     +G Y C A N  G  +++  V+++V   +     +  + + 
Sbjct: 2150 LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGG---SDELTQL 2206

Query: 576  QAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP----SGGEASFNLSLTAEHSGN 631
              + G+L+ L CE+    PP L W       L  S       SGG            +  
Sbjct: 2207 TVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAAL 2266

Query: 632  YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVV---GDLLELHCEALRGSSP 688
            YSC A+N +        +L V +   RP +T        ++   G  + L CE      P
Sbjct: 2267 YSCVASN-VAGTAKKEYNLQVYI---RPTITNSGSHPTEIIVTRGKSISLECEVQGIPPP 2322

Query: 689  ILYWFY--HEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746
             + W    H  +    +     G      ++    +G Y C A N +     +   L V 
Sbjct: 2323 TVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN-VAGMTDKKYDLSVH 2381

Query: 747  VPVSRPVLTLRAPGTHAAV-GDLLELHCEALRGSPLILYRFFHE--DVTLGNR-SSPSGG 802
             P S  +   R+P   + V  + + L CEA  G PL    +F +   V+L N     SGG
Sbjct: 2382 APPS-IIGNHRSPENISVVEKNSVSLTCEA-SGIPLPSITWFKDGWPVSLSNSVRILSGG 2439

Query: 803  ASLNL-SLTAEHSGNYSCEADNGLGAQR 829
              L L   T E +G Y+C   N  G +R
Sbjct: 2440 RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 80/321 (24%), Positives = 131/321 (40%), Gaps = 31/321 (9%)

Query: 536 SGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPP 595
           +G Y+C   +  G   S   S+F+TV    P +T+         G  + + C A     P
Sbjct: 586 AGEYHCMVSSEGG---SSAASVFLTVQ-EPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP 641

Query: 596 ILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGLVAQHSDTISLSVIV 654
            + W  ++   +GS       + +  +   A + +G Y C A+N       +    S + 
Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN----STLR 697

Query: 655 PVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGK----ISAPSGGG 710
            +  P L          +GD+  + C+      P + WF   D+ L      I  P  G 
Sbjct: 698 YIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWF-KGDLELRPSTFLIIDPLLGL 756

Query: 711 ASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPG-THAAVGDLL 769
                +   + +G Y+C A N  EA R+   T K+ + V  P + ++ P      +G  +
Sbjct: 757 LKIQETQDLD-AGDYTCVAIN--EAGRA---TGKITLDVGSPPVFIQEPADVSMEIGSNV 810

Query: 770 ELHCEALRG--SPLILYR------FFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEA 821
            L C  ++G   P I +R       F    ++ + S    GA   L+L A   G Y CEA
Sbjct: 811 TLPCY-VQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869

Query: 822 DNGLGAQRSETVTLYITGLTA 842
           +N  G  +SET T+ +TGL A
Sbjct: 870 ENQFGKIQSET-TVTVTGLVA 889



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 136/578 (23%), Positives = 200/578 (34%), Gaps = 62/578 (10%)

Query: 290  TLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRCERGASISFSLT 346
            ++  E+    +G+  ++ C T      ++  +  +G PL    H +V             
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMVLQLLKAE 3497

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLI--FEGAKVTLHCEAQ 404
            TE+SG Y C A N  G + SK   L V  P   P +N S   + I       + L C A 
Sbjct: 3498 TEDSGKYTCIASNEAG-EVSKHFILKVLEP---PHINGSEEHEEISVIVNNPLELTCIAS 3553

Query: 405  RGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA--EHSGNYYCTADNGFGPQRSKAV 462
                P +          +     + GG  +    TA  E +G Y C A +  G    K  
Sbjct: 3554 GIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEY 3612

Query: 463  SLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV 522
             + V VP  +   T    +        VTL C+     P ++    + +      +TP V
Sbjct: 3613 LVRVHVP-PNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGER---LQATPRV 3668

Query: 523  -----GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQA 577
                 GR     +   G + NY C A N  G    E + L V VP   P +         
Sbjct: 3669 RILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI-LTVNVP---PNIKGGPQSLVI 3724

Query: 578  VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEH---SGNYSC 634
            ++     L C A     P + W     V  G+ +  S  E  F L + + H   +G Y C
Sbjct: 3725 LLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF-LHIQSAHVTDTGRYLC 3783

Query: 635  EANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW-- 692
             A N         I L V VP   P +         +V     L CEA     P + W  
Sbjct: 3784 MATNAAGTDRR-RIDLQVHVP---PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRK 3839

Query: 693  ---FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPV 749
                 + D         S G     +S + + +  Y C   NG    +   V L V VP 
Sbjct: 3840 NGHLLNVDQNQNSYRLLSSGSLVI-ISPSVDDTATYECTVTNGAGDDK-RTVDLTVQVPP 3897

Query: 750  SRP------VLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSP---- 799
            S        ++T  AP           + C A  G P     +    + L  R       
Sbjct: 3898 SIADEPTDFLVTKHAPAV---------ITCTA-SGVPFPSIHWTKNGIRLLPRGDGYRIL 3947

Query: 800  SGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYI 837
            S GA   L+    H+G Y+C A N  G+     VTL++
Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAHRH-VTLHV 3984



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 107/473 (22%), Positives = 181/473 (38%), Gaps = 86/473 (18%)

Query: 40   VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILE--------VQ--ESGEYRCQAQG 89
            +TL+C+      P  T W+    G+ I+      +L         VQ  ++G Y C A  
Sbjct: 4096 ITLSCEADGLPPPDIT-WHKD--GRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN 4152

Query: 90   SPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEVT--LNNTIYKN 138
               SS      +S  L +  P          +V E    +L C A    T  +N   +K 
Sbjct: 4153 VAGSSS-----TSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAIN---WKK 4204

Query: 139  DNVLA--FLNKRT-----DFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTR 191
            DNVL    L K T     +  + +  L+D+G Y C     +     + ++ + V   FT 
Sbjct: 4205 DNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTE 4264

Query: 192  PVLRASSFQPISGNPVTLTCETQ--------LSLERSDVPLRFRFFRDDQTLGLGWSLSP 243
                        G  + L+C+           +   + +P  F        L        
Sbjct: 4265 ---LPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSEL-------- 4313

Query: 244  NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLS-PEKALNFEGT 302
               I  +  +DSG Y C A     SV       ++ V+ P   PV     P   +   G 
Sbjct: 4314 --VIERVSKEDSGTYVCTAEN---SVGFVKAIGFVYVKEP---PVFKGDYPSNWIEPLGG 4365

Query: 303  KVTLHCETQEDSLRTLYRFYHEGVPLR--HKSVRCERGASISFSLTTENSGNYYCTADNG 360
               L+CE + D   T+ ++  +GV +   H+  +   G+   +    E++G+Y C A N 
Sbjct: 4366 NAILNCEVKGDPTPTI-QWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424

Query: 361  LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA 420
             G    +++SL++  P   P++ L   E +I  G K+ L+C+A     P +  +  +G +
Sbjct: 4425 AGVV-ERSMSLTLQSP---PIITLEPVETVINAGGKIILNCQATGEPQPTI-TWSRQGHS 4479

Query: 421  L---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPV 470
            +   +R +  S   + I+     E +  + C A N  G       S+ V VPV
Sbjct: 4480 ISWDDRVNVLSNNSLYIA-DAQKEDTSEFECVARNLMG-------SVLVRVPV 4524


>gi|126116592 Fc fragment of IgG, low affinity IIc, receptor [Homo
           sapiens]
          Length = 323

 Score =  111 bits (278), Expect = 3e-24
 Identities = 73/198 (36%), Positives = 98/198 (49%), Gaps = 8/198 (4%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  +L LAPV+G  A  P+ ++ L+P W  V Q + VTLTC+G          W+H 
Sbjct: 28  MLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHN 87

Query: 61  YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116
             G  I   T  +        +SGEY CQ   + LS PVHL   S  L+LQ P L   EG
Sbjct: 88  --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 145

Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175
           +++VLRC + K +  +  T ++N     F     +F IP A    +G Y CTG       
Sbjct: 146 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 204

Query: 176 VSSNTVKIQVQEPFTRPV 193
            SS  V I VQ P + P+
Sbjct: 205 YSSKPVTITVQAPSSSPM 222



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 57/245 (23%), Positives = 94/245 (38%), Gaps = 29/245 (11%)

Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732
           D + L C       S  + WF++ ++       P+    S+        SG Y+C+    
Sbjct: 65  DSVTLTCRGTHSPESDSIPWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 116

Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
            +   S+ V L V        L L+ P      G+ + L C + +  PL+   FF     
Sbjct: 117 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 168

Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849
              +S     +  N S+      HSG+Y C  + G     S+ VT+ +   +++  G   
Sbjct: 169 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 225

Query: 850 TGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQ 909
             V  G+   A +AA   L+YC       +K  S  +  P  +   EP    + A  + Q
Sbjct: 226 VAVVTGIAVAAIVAAVVALIYC------RKKRISANSTDPVKAAQFEPPGRQMIAIRKRQ 279

Query: 910 PVYTN 914
           P  TN
Sbjct: 280 PEETN 284



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 60/273 (21%), Positives = 99/273 (36%), Gaps = 30/273 (10%)

Query: 283 PASHP--VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340
           PA+ P  VL L P+     +   VTL C            ++H G       +      S
Sbjct: 44  PAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHNG-----NLIPTHTQPS 98

Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400
             F     +SG Y C       + P     LS  + +  P L          EG  + L 
Sbjct: 99  YRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLR 151

Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460
           C + +    +   F   G +  ++ + S    +I       HSG+Y+CT + G+    SK
Sbjct: 152 CHSWKDKPLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSK 208

Query: 461 AVSLSVTVPVSHPV-----LTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515
            V+++V  P S P+     +    A A         ++C  +R S        +   P+ 
Sbjct: 209 PVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISA-------NSTDPVK 261

Query: 516 SSSTPSVGRVSFSFSLTE-GHSGNYYCTADNGF 547
           ++     GR   +    +   + N Y TAD G+
Sbjct: 262 AAQFEPPGRQMIAIRKRQPEETNNDYETADGGY 294



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 39/172 (22%), Positives = 70/172 (40%), Gaps = 18/172 (10%)

Query: 599 WFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSR 658
           WF++ ++       P+  + S+        SG Y+C+     +   SD + L+V+     
Sbjct: 84  WFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL----S 130

Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLT 718
             L  + P  +   G+ + L C + +    +   F+      GK    S    +F++   
Sbjct: 131 EWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIPQA 186

Query: 719 TE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLL 769
              HSG Y C  + G     S+ VT+ V  P S P+  + A  T  AV  ++
Sbjct: 187 NHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIV 238



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 43/190 (22%), Positives = 69/190 (36%), Gaps = 21/190 (11%)

Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440
           VL L      + +   VTL C            + H G  +   +  S       F    
Sbjct: 51  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHNGNLIPTHTQPS-----YRFKANN 105

Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500
             SG Y C            ++S  V + V    L L +      EG T+ L C   +  
Sbjct: 106 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 158

Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557
           P +   F+       +  +    R   +FS+ +    HSG+Y+CT + G+    S+ V++
Sbjct: 159 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 212

Query: 558 FVTVPVSRPI 567
            V  P S P+
Sbjct: 213 TVQAPSSSPM 222


>gi|132814489 low affinity immunoglobulin gamma Fc region receptor
           III-B precursor [Homo sapiens]
          Length = 233

 Score =  110 bits (275), Expect = 6e-24
 Identities = 76/209 (36%), Positives = 108/209 (51%), Gaps = 16/209 (7%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58
           +LL   LL+L     +    P+ ++FL+P W +V + + VTL C+G   YSP+   T+W+
Sbjct: 4   LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQG--AYSPEDNSTQWF 61

Query: 59  HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114
           H    + ++     +       V +SGEYRCQ   S LS PV L+     L+LQAP  VF
Sbjct: 62  H---NENLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 118

Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172
            E D + LRC +     L+   Y +N     + +  +DFHIP A LKD+G+Y C G   S
Sbjct: 119 KEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGS 178

Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQP 201
              VSS TV I + +     V   SSF P
Sbjct: 179 -KNVSSETVNITITQGLA--VSTISSFSP 204



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 43/182 (23%), Positives = 85/182 (46%), Gaps = 18/182 (9%)

Query: 112 SVFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYK 170
           SV E DSV L+C+       N+T  + N+N+++  ++ + + I  A + D+G YRC    
Sbjct: 36  SVLEKDSVTLKCQGAYSPEDNSTQWFHNENLIS--SQASSYFIDAATVNDSGEYRC---- 89

Query: 171 ESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFR 230
           ++     S+ V+++V   +   +L+A  +     +P+ L C +  +     V    +  +
Sbjct: 90  QTNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVTY-LQNGK 146

Query: 231 DDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290
           D +     +  + +F I     KDSG Y+C+      +V S++    + + I     V T
Sbjct: 147 DRKY----FHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSET----VNITITQGLAVST 198

Query: 291 LS 292
           +S
Sbjct: 199 IS 200


>gi|110347451 platelet/endothelial cell adhesion molecule [Homo
           sapiens]
          Length = 738

 Score =  109 bits (273), Expect = 1e-23
 Identities = 161/703 (22%), Positives = 278/703 (39%), Gaps = 82/703 (11%)

Query: 299 FEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTAD 358
           F     T H + Q   L     FY + V   + S      +     +   +SG Y CT  
Sbjct: 58  FADVSTTSHVKPQHQML-----FYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVI 112

Query: 359 NGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFH--- 415
                K +    L V   V  P + L   E +  +G  V ++C       PI +      
Sbjct: 113 VNNKEKTTAEYQLLVE-GVPSPRVTLDKKEAI--QGGIVRVNCSVPEEKAPIHFTIEKLE 169

Query: 416 -HEGAALERRSANSAGGVAISFSLTAEHSG---NYYCTAD--NGFGPQRSKAVS---LSV 466
            +E     +R  NS     +      E      ++ C A   +G   Q S++     ++V
Sbjct: 170 LNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTV 229

Query: 467 TVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-----RGSPQILYQFYHEDMPLWSSSTPS 521
           T   S P   +S    +  EGA + + C +Q     +  P+I+ Q   +D  + + +   
Sbjct: 230 TESFSTPKFHISPT-GMIMEGAQLHIKCTIQVTHLAQEFPEIIIQ---KDKAIVAHNRHG 285

Query: 522 VGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGD 581
              V    ++ E HSGNY C  ++    + S +V + +T   S+P L           G+
Sbjct: 286 NKAVYSVMAMVE-HSGNYTCKVESSRISKVSSIV-VNITELFSKPELESSFTHLDQ--GE 341

Query: 582 LLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLV 641
            L L C  P G+PP  +    ED  +  +         F    +   SG Y C A    V
Sbjct: 342 RLNLSCSIP-GAPPANFTIQKEDTIVSQTQ-------DFTKIASKSDSGTYICTAGIDKV 393

Query: 642 AQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701
            + S+T+ + V   +S+P +++ A + + + G  +E+ CE++ G+ PI Y        L 
Sbjct: 394 VKKSNTVQIVVCEMLSQPRISYDA-QFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLE 452

Query: 702 KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQR--SEMVTLKVAVPVSRPVLTLRAP 759
             +  S   A F  + T +    Y C ADN     +  SE++ +KV  PV    +++ + 
Sbjct: 453 NSTKNSNDPAVFKDNPTEDVE--YQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSS 510

Query: 760 GTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGAS---LNLSLTAEHSGN 816
               +  D++ L C    GS  I Y+F+ E          S            + E  G 
Sbjct: 511 KVVESGEDIV-LQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKASKEQEGE 569

Query: 817 YSC----EADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCW 872
           Y C     A++     RS+ +T+ +  L   + G  A  + G ++++  +AA      C+
Sbjct: 570 YYCTAFNRANHASSVPRSKILTVRVI-LAPWKKGLIAVVIIGVIIALLIIAA-----KCY 623

Query: 873 LSRKAGRK----PASDPARSPSDSDSQEPTYHNVPAWEE-----------LQPVYTNANP 917
             RKA  K      S PA    +S++++ +  N+ A              ++P+  N  P
Sbjct: 624 FLRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEANSHYGHNDDVRNHAMKPINDNKEP 683

Query: 918 RGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA 960
              +V Y+EV++       + A   + L  K +  +YSEV+ A
Sbjct: 684 LNSDVQYTEVQV-------SSAESHKDLGKKDTETVYSEVRKA 719



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 132/575 (22%), Positives = 234/575 (40%), Gaps = 61/575 (10%)

Query: 203 SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSL---SPNFQITAMWSKDSGFYW 259
           +G  +TL C   +S      P     F  D  L    S    + ++ I  +   DSG Y 
Sbjct: 49  NGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYK 108

Query: 260 CKAATMPYSVISDSPRSWIQVQIPAS---HPVLTLSPEKALNFEGTKVTLHCETQEDSLR 316
           C        ++++  ++  + Q+       P +TL  ++A+  +G  V ++C   E+  +
Sbjct: 109 CTV------IVNNKEKTTAEYQLLVEGVPSPRVTLDKKEAI--QGGIVRVNCSVPEE--K 158

Query: 317 TLYRFYHEGVPLRHKSVRCERGAS--------ISFSLTTENSG-NYYCTADNGLG----- 362
               F  E + L  K V+ +R  +        + F +  ++   ++ C A    G     
Sbjct: 159 APIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQT 218

Query: 363 AKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL----PILYQFHHEG 418
           ++ +K+  ++VT   S P  ++S P  +I EGA++ + C  Q   L    P +     + 
Sbjct: 219 SESTKSELVTVTESFSTPKFHIS-PTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKA 277

Query: 419 AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLS 478
                R  N A     S     EHSGNY C  ++    + SK  S+ V +        L 
Sbjct: 278 IVAHNRHGNKA---VYSVMAMVEHSGNYTCKVESS---RISKVSSIVVNITELFSKPELE 331

Query: 479 SAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGN 538
           S+     +G  + L C +  G+P   +    ED  +  S T    +++     ++  SG 
Sbjct: 332 SSFTHLDQGERLNLSCSIP-GAPPANFTIQKEDTIV--SQTQDFTKIA-----SKSDSGT 383

Query: 539 YYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY 598
           Y CTA      ++S  V + V   +S+P ++    + + + G  +E+ CE+  G+ PI Y
Sbjct: 384 YICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDA-QFEVIKGQTIEVRCESISGTLPISY 442

Query: 599 WFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANN--GLVAQHSDTISLSVIVPV 656
                   L +S+  S   A F  + T +    Y C A+N        S+ + + VI PV
Sbjct: 443 QLLKTSKVLENSTKNSNDPAVFKDNPTEDVE--YQCVADNCHSHAKMLSEVLRVKVIAPV 500

Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASF--N 714
               ++  + +     G+ + L C    GS PI Y FY E          S    +F   
Sbjct: 501 DEVQISILSSKV-VESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTK 559

Query: 715 LSLTTEHSGIYSC----EADNGLEAQRSEMVTLKV 745
              + E  G Y C     A++     RS+++T++V
Sbjct: 560 QKASKEQEGEYYCTAFNRANHASSVPRSKILTVRV 594



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 138/580 (23%), Positives = 230/580 (39%), Gaps = 68/580 (11%)

Query: 112 SVFEGDSVVLRCRAKAEVTLN-----NTIYKNDNVLAF----LNKRTDFHIPHACLKDNG 162
           +V  G ++ L+C A    T +       ++  D+VL +    +     + IP   + D+G
Sbjct: 46  TVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSG 105

Query: 163 AYRCT-----------GYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTC 211
            Y+CT            Y+     V S  V +  +E     ++R +   P    P+  T 
Sbjct: 106 TYKCTVIVNNKEKTTAEYQLLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTI 165

Query: 212 ETQLSLERSDVPL-RFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP--YS 268
           E +L L    V L R +  RD   + L + +    ++ +        + C+A  +   + 
Sbjct: 166 E-KLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLS--------FRCQARIISGIHM 216

Query: 269 VISDSPRS-WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVP 327
             S+S +S  + V    S P   +SP   +  EG ++ + C  Q   +  L + + E + 
Sbjct: 217 QTSESTKSELVTVTESFSTPKFHISP-TGMIMEGAQLHIKCTIQ---VTHLAQEFPEIII 272

Query: 328 LRHKSV----RCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLN 383
            + K++    R    A  S     E+SGNY C  ++   +K S  V +++T   S P L 
Sbjct: 273 QKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIV-VNITELFSKPELE 331

Query: 384 LSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHS 443
            S     + +G ++ L C    G+ P  +    E   + +           +   +   S
Sbjct: 332 SSFTH--LDQGERLNLSCSIP-GAPPANFTIQKEDTIVSQTQ-------DFTKIASKSDS 381

Query: 444 GNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQI 503
           G Y CTA      ++S  V + V   +S P ++   A+    +G T+ + CE   G+  I
Sbjct: 382 GTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISY-DAQFEVIKGQTIEVRCESISGTLPI 440

Query: 504 LYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADN--GFGPQRSEVVSLFVTV 561
            YQ       L +S+  S     F  + TE     Y C ADN        SEV+ + V  
Sbjct: 441 SYQLLKTSKVLENSTKNSNDPAVFKDNPTE--DVEYQCVADNCHSHAKMLSEVLRVKVIA 498

Query: 562 PVSR---PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEA 618
           PV      IL+ +V  +    G+ + L C    GS PI Y FY E          S    
Sbjct: 499 PVDEVQISILSSKVVES----GEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQ 554

Query: 619 SF--NLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656
           +F      + E  G Y C A N   A H+ ++  S I+ V
Sbjct: 555 AFWTKQKASKEQEGEYYCTAFNR--ANHASSVPRSKILTV 592



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 59/265 (22%), Positives = 106/265 (40%), Gaps = 49/265 (18%)

Query: 27  LQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKE--ILRETPD--NILEVQESGE 82
           L+  +T + QGER+ L+C      S       +  + KE  I+ +T D   I    +SG 
Sbjct: 330 LESSFTHLDQGERLNLSC------SIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGT 383

Query: 83  YRCQA-------QGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA-KAEVTLNNT 134
           Y C A       + + +   V    S   +   A   V +G ++ +RC +    + ++  
Sbjct: 384 YICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQ 443

Query: 135 IYKNDNVLAFLNKRTDFHIPHACLKDNGA----YRCTGYK-ESCCPVSSNTVKIQVQEPF 189
           + K   VL    K ++     A  KDN      Y+C      S   + S  ++++V  P 
Sbjct: 444 LLKTSKVLENSTKNSN---DPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPV 500

Query: 190 TRPVLRASSFQPI-SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQIT 248
               +   S + + SG  + L C    ++     P+ ++F+R+ +         P +Q+T
Sbjct: 501 DEVQISILSSKVVESGEDIVLQC----AVNEGSGPITYKFYREKEG-------KPFYQMT 549

Query: 249 -----AMWSK------DSGFYWCKA 262
                A W+K        G Y+C A
Sbjct: 550 SNATQAFWTKQKASKEQEGEYYCTA 574


>gi|50511928 Fc fragment of IgG, low affinity IIb, receptor isoform
           4 [Homo sapiens]
          Length = 309

 Score =  108 bits (269), Expect = 3e-23
 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 9/198 (4%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  +L LAPV+G  A  P+ ++ L+P W  V Q + VTLTC+G         +W+H 
Sbjct: 28  MLLWTAVLFLAPVAGTPA-PPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 86

Query: 61  YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116
             G  I   T  +        +SGEY CQ   + LS PVHL   S  L+LQ P L   EG
Sbjct: 87  --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 144

Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175
           +++VLRC + K +  +  T ++N     F     +F IP A    +G Y CTG       
Sbjct: 145 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 203

Query: 176 VSSNTVKIQVQEPFTRPV 193
            SS  V I VQ P + P+
Sbjct: 204 YSSKPVTITVQAPSSSPM 221



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 43/187 (22%), Positives = 70/187 (37%), Gaps = 15/187 (8%)

Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTT 347
           VL L P+     +   VTL C           +++H G       +      S  F    
Sbjct: 50  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPSYRFKANN 104

Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
            +SG Y C       + P     LS  + +  P L          EG  + L C + +  
Sbjct: 105 NDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLRCHSWKDK 157

Query: 408 LPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVT 467
             +   F   G +  ++ + S    +I       HSG+Y+CT + G+    SK V+++V 
Sbjct: 158 PLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSKPVTITVQ 214

Query: 468 VPVSHPV 474
            P S P+
Sbjct: 215 APSSSPM 221



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 47/202 (23%), Positives = 79/202 (39%), Gaps = 23/202 (11%)

Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732
           D + L C       S  + WF++ ++       P+    S+        SG Y+C+    
Sbjct: 64  DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 115

Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
            +   S+ V L V        L L+ P      G+ + L C + +  PL+   FF     
Sbjct: 116 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 167

Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849
              +S     +  N S+      HSG+Y C  + G     S+ VT+ +   +++  G   
Sbjct: 168 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 224

Query: 850 TGVAGGLLSIAGLAAGALLLYC 871
             V  G+   A +AA   L+YC
Sbjct: 225 VAVVTGIAVAAIVAAVVALIYC 246



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%)

Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440
           VL L      + +   VTL C           Q+ H G  +   +  S       F    
Sbjct: 50  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 104

Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500
             SG Y C            ++S  V + V    L L +      EG T+ L C   +  
Sbjct: 105 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 157

Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557
           P +   F+       +  +    R   +FS+ +    HSG+Y+CT + G+    S+ V++
Sbjct: 158 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 211

Query: 558 FVTVPVSRPI 567
            V  P S P+
Sbjct: 212 TVQAPSSSPM 221



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 43/191 (22%), Positives = 77/191 (40%), Gaps = 23/191 (12%)

Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656
           + WF++ ++       P+  + S+        SG Y+C+     +   SD + L+V+   
Sbjct: 81  IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 128

Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716
               L  + P  +   G+ + L C + +    +   F+      GK    S    +F++ 
Sbjct: 129 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 183

Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLE----- 770
                HSG Y C  + G     S+ VT+ V  P S P+  + A  T  AV  ++      
Sbjct: 184 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVAL 243

Query: 771 LHCEALRGSPL 781
           ++C   R S L
Sbjct: 244 IYCRKKRISAL 254


>gi|50511932 Fc fragment of IgG, low affinity IIb, receptor isoform
           2 [Homo sapiens]
          Length = 290

 Score =  108 bits (269), Expect = 3e-23
 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 9/198 (4%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60
           MLLW  +L LAPV+G  A  P+ ++ L+P W  V Q + VTLTC+G         +W+H 
Sbjct: 28  MLLWTAVLFLAPVAGTPA-PPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 86

Query: 61  YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116
             G  I   T  +        +SGEY CQ   + LS PVHL   S  L+LQ P L   EG
Sbjct: 87  --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 144

Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175
           +++VLRC + K +  +  T ++N     F     +F IP A    +G Y CTG       
Sbjct: 145 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 203

Query: 176 VSSNTVKIQVQEPFTRPV 193
            SS  V I VQ P + P+
Sbjct: 204 YSSKPVTITVQAPSSSPM 221



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 50/217 (23%), Positives = 83/217 (38%), Gaps = 23/217 (10%)

Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732
           D + L C       S  + WF++ ++       P+    S+        SG Y+C+    
Sbjct: 64  DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 115

Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
            +   S+ V L V        L L+ P      G+ + L C + +  PL+   FF     
Sbjct: 116 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 167

Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849
              +S     +  N S+      HSG+Y C  + G     S+ VT+ +   +++  G   
Sbjct: 168 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 224

Query: 850 TGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPA 886
             V  G+   A +AA   L+YC   R +      D A
Sbjct: 225 VAVVTGIAVAAIVAAVVALIYCRKKRISANPTNPDEA 261



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 43/187 (22%), Positives = 70/187 (37%), Gaps = 15/187 (8%)

Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTT 347
           VL L P+     +   VTL C           +++H G       +      S  F    
Sbjct: 50  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPSYRFKANN 104

Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
            +SG Y C       + P     LS  + +  P L          EG  + L C + +  
Sbjct: 105 NDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLRCHSWKDK 157

Query: 408 LPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVT 467
             +   F   G +  ++ + S    +I       HSG+Y+CT + G+    SK V+++V 
Sbjct: 158 PLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSKPVTITVQ 214

Query: 468 VPVSHPV 474
            P S P+
Sbjct: 215 APSSSPM 221



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%)

Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440
           VL L      + +   VTL C           Q+ H G  +   +  S       F    
Sbjct: 50  VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 104

Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500
             SG Y C            ++S  V + V    L L +      EG T+ L C   +  
Sbjct: 105 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 157

Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557
           P +   F+       +  +    R   +FS+ +    HSG+Y+CT + G+    S+ V++
Sbjct: 158 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 211

Query: 558 FVTVPVSRPI 567
            V  P S P+
Sbjct: 212 TVQAPSSSPM 221



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 18/174 (10%)

Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656
           + WF++ ++       P+  + S+        SG Y+C+     +   SD + L+V+   
Sbjct: 81  IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 128

Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716
               L  + P  +   G+ + L C + +    +   F+      GK    S    +F++ 
Sbjct: 129 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 183

Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLL 769
                HSG Y C  + G     S+ VT+ V  P S P+  + A  T  AV  ++
Sbjct: 184 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIV 237


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  107 bits (268), Expect = 4e-23
 Identities = 178/816 (21%), Positives = 311/816 (38%), Gaps = 78/816 (9%)

Query: 108  QAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFH----IPHACLKDNGA 163
            Q   SV  G  V   C AK++      ++   +      +  DF+    I +  L D G 
Sbjct: 1778 QRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGT 1837

Query: 164  YRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVP 223
            Y CTG         + T+ +Q     + PV+     Q ++  P  L  E + S   S  P
Sbjct: 1838 YVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQ-LTVQPGQLA-EFRCSATGSPTP 1895

Query: 224  LRFRFFRDDQTLGLGWSLSPNFQI-------TAMWSKDSGFYWCKAATMPYSVISDSPRS 276
                    + T G G  L    QI        A+   D   Y C+A +     ++   R+
Sbjct: 1896 TL------EWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVA---RA 1946

Query: 277  WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTL-YRFYHEGVPLRHKSVRC 335
             + V      P + +SPE+     G  V L+C        T+ +R     +P + +S R 
Sbjct: 1947 VLHVH-GGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT 2005

Query: 336  ERGASISFSLTTENSGNYYCTADNGLGAKPSK--AVSLSVTVPVSHPVLNLSSPEDLIFE 393
            +    +  ++TT ++G Y C A +  G   ++   V LS +   S P + + S    + E
Sbjct: 2006 DIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSAS-DASPPPVKIESSSPSVTE 2064

Query: 394  GAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNG 453
            G  + L+C    GS      ++  G +L   +      + +   ++   SG Y C  +NG
Sbjct: 2065 GQTLDLNCVVA-GSAHAQVTWYRRGGSLPPHTQVHGSRLRLP-QVSPADSGEYVCRVENG 2122

Query: 454  FGPQRSKAVSLSVT-----------VPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSP 501
             GP+ + ++++SV            VP S   + +  + +   EG T+ L+C V  +   
Sbjct: 2123 SGPKEA-SITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHA 2181

Query: 502  QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTV 561
            Q+ +      +P    +  S+ R+     +T   SG Y C      GP  + V+      
Sbjct: 2182 QVTWHKRGGSLPARHQTHGSLLRLH---QVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238

Query: 562  PVSRPILTLRVPRAQAVV--GDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSG---- 615
             +  PI  +R+  + + V  G  L+L C     +   + W+          S P+     
Sbjct: 2239 VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR------GGSLPARHQVR 2292

Query: 616  GEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI-----LTFRAPRAQA 670
            G   +    +   +G Y C A+NG+ A  + T++ +    ++ P      +      +Q 
Sbjct: 2293 GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV 2352

Query: 671  VVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEA- 729
              G  L+L+C     S   + W  H+      +   + G        +   SG Y C   
Sbjct: 2353 AEGQTLDLNCVVPGQSHAQVTW--HKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL 2410

Query: 730  DNGLEAQRSEMVTLKVAVPVSR----PVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785
             + +  + S +VT++ A  V      P + + +  +  A G  L+L+C  + G       
Sbjct: 2411 GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC-LVAGQAHAQVT 2469

Query: 786  FFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRS 845
            +     +L  R    G     L +T   SG Y C      G Q +      +  +    S
Sbjct: 2470 WHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASV----LVTIQQRLS 2525

Query: 846  GPFATGVAGGL---LSIAGLAAGALL-LYCWLSRKA 877
            G  + GVA  +    S A LA G  L L C ++ +A
Sbjct: 2526 GSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA 2561



 Score =  101 bits (252), Expect = 3e-21
 Identities = 206/922 (22%), Positives = 339/922 (36%), Gaps = 133/922 (14%)

Query: 9    VLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILR 68
            VL  +       P P + ++   +TV +G+ + L+C        Q T WY R        
Sbjct: 2231 VLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT-WYKRGGSLPARH 2289

Query: 69   ETPDNILEV-----QESGEYRCQA---------------QGSPLSSPVHLDFSSASLILQ 108
            +   + L +      ++G+Y C+A               QG+ L+ P      S   I  
Sbjct: 2290 QVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPA----GSTQPIRI 2345

Query: 109  APLS--VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTD--FHIPHACLKDNGAY 164
             P S  V EG ++ L C    +     T +K    L   ++       +  A   D+G Y
Sbjct: 2346 EPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEY 2405

Query: 165  RCTGYKESCCPVSSNTVKIQ----VQEPFTRPVLR--ASSFQPISGNPVTLTC------E 212
             C     S    +S  V I+    V      P +R  +SS Q   G  + L C       
Sbjct: 2406 VCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAH 2465

Query: 213  TQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK----AATMPYS 268
             Q++  +    L  R       L L        Q+T     DSG Y C+    + T   S
Sbjct: 2466 AQVTWHKRGGSLPARHQVHGSRLRL-------LQVTPA---DSGEYVCRVVGSSGTQEAS 2515

Query: 269  VISDSPRSWIQVQIPASH------PVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFY 322
            V+       IQ ++  SH      PV   S   +L   G  + L+C     +  T+  + 
Sbjct: 2516 VLVT-----IQQRLSGSHSQGVAYPVRIESSSASLA-NGHTLDLNCLVASQAPHTITWYK 2569

Query: 323  HEG-VPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLGAKPSKAV-----SLSVTV 375
              G +P RH+ V    G+ +    +T  +SG Y C   NG G++ +  +     S S  V
Sbjct: 2570 RGGSLPSRHQIV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHV 2625

Query: 376  PVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAIS 435
            P   P + + S    + EG  + L+C   R    I+  +   G+   R   +  G     
Sbjct: 2626 PSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH--GSHLRL 2683

Query: 436  FSLTAEHSGNYYCTADNGFGPQRSKAV------SLSVTVPVSHPVLTLSSAEALTFEGAT 489
              ++   SG Y C A+N      +  V      + S + P S   + + S+ +   EG T
Sbjct: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743

Query: 490  VTLHCEVQ-RGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFG 548
            + L+C V  +   Q+ +      +P    +  S  R+     ++   SG Y C      G
Sbjct: 2744 LDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHH---VSPADSGEYVCRVMGSSG 2800

Query: 549  PQRSEVV---------SLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYW 599
            P  + V+         ++ V  P   P + +    ++   G  L+L C  P  +   + W
Sbjct: 2801 PLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTW 2860

Query: 600  FYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIV----- 654
             +     L +     G     N    A+ SG YSC+     V   S T+  SV+V     
Sbjct: 2861 -HKRGGNLPARHQVHGPLLRLNQVSPAD-SGEYSCQ-----VTGSSGTLEASVLVTIEPS 2913

Query: 655  ---PVSRPILT----FRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPS 707
               P+  P L       A  +    G  L+L+C  + G +     +Y    +L       
Sbjct: 2914 SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNC-VVPGQAHAQVTWYKRGGSLPARHQTH 2972

Query: 708  GGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSR--------PVLTLRAP 759
            G     +L ++   SG Y C A +G   ++    T  V VP S         PV+++  P
Sbjct: 2973 GSQLRLHL-VSPADSGEYVCRAASGPGPEQEASFT--VTVPPSEGSSYRLRSPVISIDPP 3029

Query: 760  GTHAAVGDLLELHCEALRGS-PLIL-YRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNY 817
             +    G      C    G+ P+ L ++  ++++      SP+G     +     + G Y
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTY 3089

Query: 818  SCEADNGLGAQRSETVTLYITG 839
             C A N  G  +S  V L + G
Sbjct: 3090 RCVASNAYGVAQS-VVNLSVHG 3110



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 184/799 (23%), Positives = 296/799 (37%), Gaps = 110/799 (13%)

Query: 112  SVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFH-----IPHACLKDNGAYRC 166
            SV EG ++ L C          T Y+    L      T  H     +P     D+G Y C
Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP---PHTQVHGSRLRLPQVSPADSGEYVC 2117

Query: 167  -----TGYKESCCPVS----SNTVKIQVQEP-FTRPV-LRASSFQPISGNPVTLTC---- 211
                 +G KE+   VS    +++       P  TRP+ +  SS     G  + L C    
Sbjct: 2118 RVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPG 2177

Query: 212  --ETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK----AATM 265
                Q++  +    L  R     QT G   SL    Q+T     DSG Y C     +  +
Sbjct: 2178 QAHAQVTWHKRGGSLPARH----QTHG---SLLRLHQVTPA---DSGEYVCHVVGTSGPL 2227

Query: 266  PYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG 325
              SV+     S     IP   P + +    +   EG  + L C     +   +  +   G
Sbjct: 2228 EASVLVTIEAS----VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG 2283

Query: 326  -VPLRHKSVRCERGASIS-FSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPV-- 381
             +P RH+     RG+ +  F  +  ++G Y C A NG+ A  +  V+ +    +++P   
Sbjct: 2284 SLPARHQV----RGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGS 2339

Query: 382  ---LNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSL 438
               + +      + EG  + L+C    G       +H  G +L  R   + G +   +  
Sbjct: 2340 TQPIRIEPSSSQVAEGQTLDLNCVVP-GQSHAQVTWHKRGGSLPVRH-QTHGSLLRLYQA 2397

Query: 439  TAEHSGNYYCTADNGFGP-QRSKAVSL----SVTVPVSHPVLTLSSAEALTFEGATVTLH 493
            +   SG Y C       P + S  V++    SV      P + + S+ +   EG T+ L+
Sbjct: 2398 SPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLN 2457

Query: 494  CEVQ-RGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRS 552
            C V  +   Q+ +      +P       S  R+     +T   SG Y C      G Q +
Sbjct: 2458 CLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRL---LQVTPADSGEYVCRVVGSSGTQEA 2514

Query: 553  EVVSLFVTVP----------VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYH 602
             V+   VT+           V+ P+  +    A    G  L+L+C     +P  + W Y 
Sbjct: 2515 SVL---VTIQQRLSGSHSQGVAYPV-RIESSSASLANGHTLDLNCLVASQAPHTITW-YK 2569

Query: 603  EDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTI-----SLSVIVPVS 657
               +L S     G        +T   SG Y C  +NG  ++ +  I     S S  VP  
Sbjct: 2570 RGGSLPSRHQIVGSRLRIP-QVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628

Query: 658  RPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSL 717
             P +   +     V G  L+L+C   R    I+ W Y    +L       G     +  +
Sbjct: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITW-YKRGGSLPSRHQTHGSHLRLH-QM 2686

Query: 718  TTEHSGIYSCEADNGLEAQRSEMVTL------KVAVPVSRPVLTLRAPGTHAAVGDLLEL 771
            +   SG Y C A+N ++A  + +V          + P S   + + +  +H A G+ L+L
Sbjct: 2687 SVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746

Query: 772  HCEALRGSPLILYRFFHEDVTLGNR--SSPSGGASLNLSLTAEH-----SGNYSCEADNG 824
            +C        ++    H  VT   R  S PS   +    L   H     SG Y C     
Sbjct: 2747 NC--------VVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGS 2798

Query: 825  LG-AQRSETVTLYITGLTA 842
             G  + S  VT+  +G +A
Sbjct: 2799 SGPLEASVLVTIEASGSSA 2817



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 192/822 (23%), Positives = 288/822 (35%), Gaps = 102/822 (12%)

Query: 79   ESGEYRCQAQGS--PLSSPVHLDFS---SASLILQAP------------LSVFEGDSVVL 121
            +SGEY C+  GS  PL + V +      S+++ + AP              V EG ++ L
Sbjct: 2787 DSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDL 2846

Query: 122  RCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLK-----DNGAYRCTGYKESCCPV 176
            +C    +     T +K    L     R   H P   L      D+G Y C     S    
Sbjct: 2847 KCVVPGQAHAQVTWHKRGGNLP---ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLE 2903

Query: 177  SSNTVKIQVQEPFTRPV--------LRASSFQPISGNPVTLTC------ETQLSLERSDV 222
            +S  V I+   P   P         + ASS     G  + L C        Q++  +   
Sbjct: 2904 ASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGG 2963

Query: 223  PLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQI 282
             L  R     QT G         ++  +   DSG Y C+AA+ P         +   V +
Sbjct: 2964 SLPARH----QTHG------SQLRLHLVSPADSGEYVCRAASGP----GPEQEASFTVTV 3009

Query: 283  PASH--------PVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVR 334
            P S         PV+++ P  +   +G   +  C   + +      +      L      
Sbjct: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 3069

Query: 335  CERGASISFSLTT-ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE 393
               G+ I+   T   N G Y C A N  G   S  V+LSV  P +  VL    PE  ++ 
Sbjct: 3070 SPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS-VVNLSVHGPPTVSVL----PEGPVWV 3124

Query: 394  --GAKVTLHCEA--QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHS--GNYY 447
              G  VTL C +  +  S     +     A LE+R+       A+    +A+ S  G Y 
Sbjct: 3125 KVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYV 3184

Query: 448  CTADNGFGPQRSKAVSLSVTVPVSH--PVLTLSSAEALTFEGATVTLHCEVQRGSPQILY 505
            C A N  G  + +   +  T  ++   P +    AE     G T TL C    GSP    
Sbjct: 3185 CLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT-GSPAPTI 3243

Query: 506  QFYHEDMPL-WSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVS 564
             +     PL W       G       + +  SG Y C A +  G   + ++ L V  P  
Sbjct: 3244 HWSKLRSPLPWQHRLE--GDTLIIPRVAQQDSGQYICNATSPAGHAEATII-LHVESP-- 3298

Query: 565  RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSL 624
             P  T     A    G+ ++L C A  G+PP+ + +     +L   +        F  + 
Sbjct: 3299 -PYATTVPEHASVQAGETVQLQCLA-HGTPPLTFQWSRVGSSLPGRATARNELLHFERA- 3355

Query: 625  TAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAV----------VGD 674
              E SG Y C   N + +  +    L    P S P  +  A     V          +G 
Sbjct: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGA 3415

Query: 675  LLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL- 733
             +E HC         L WF          S   G     NL  + +  G Y C+A     
Sbjct: 3416 SVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQ--GTYICQAHGPWG 3473

Query: 734  EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL 793
            +AQ S  + ++    V   ++ +R       VG  +E  C AL G P     +      L
Sbjct: 3474 KAQASAQLVIQALPSV---LINIRTSVQTVVVGHAVEFECLAL-GDPKPQVTWSKVGGHL 3529

Query: 794  GNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTL 835
                  SGG      +    +G Y C A N  G  +S  + L
Sbjct: 3530 RPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLL 3571



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 184/885 (20%), Positives = 321/885 (36%), Gaps = 114/885 (12%)

Query: 23   PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDN-------IL 75
            P++ + PP  TV  G+     C      SP  T  +    G ++  +   +        +
Sbjct: 1866 PVVSIHPPQLTVQPGQLAEFRCSATG--SPTPTLEWTGGPGGQLPAKAQIHGGILRLPAV 1923

Query: 76   EVQESGEYRCQAQGSP----LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEV 129
            E  +  +Y C+A  S       + +H+       +  +P    V  G +V L CRA    
Sbjct: 1924 EPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVP 1983

Query: 130  TLNNTIYKNDNVL--AFLNKRTDFH---IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQ 184
            +   T  K    L     ++RTD     IP     D G Y C     +  P  +   +IQ
Sbjct: 1984 SATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCV----ATSPAGTAQARIQ 2039

Query: 185  V-----QEPFTRPV-LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLG 238
            V      +    PV + +SS     G  + L C    S        R            G
Sbjct: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR-----------RG 2088

Query: 239  WSLSPNFQI-------TAMWSKDSGFYWC--------KAATMPYSVISDSPRSWIQVQIP 283
             SL P+ Q+         +   DSG Y C        K A++  SV+  +        +P
Sbjct: 2089 GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVP 2148

Query: 284  ASHPVLTLSPEKALNFEGTKVTLHCETQ-EDSLRTLYRFYHEGVPLRHKSVRCERGASIS 342
             S   + + P  +   EG  + L+C    +   +  +      +P RH++     G+ + 
Sbjct: 2149 GSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQT----HGSLLR 2204

Query: 343  F-SLTTENSGNYYCTADNGLG-AKPSKAVSLSVTV-PVSHPVLNLSSPEDLIFEGAKVTL 399
               +T  +SG Y C      G  + S  V++  +V P   P + + S    + EG  + L
Sbjct: 2205 LHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264

Query: 400  HCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459
             C    G       ++  G +L  R     G     F  +   +G Y C A NG     +
Sbjct: 2265 SC-VVAGQAHAQVTWYKRGGSLPARH-QVRGSRLYIFQASPADAGQYVCRASNGMEASIT 2322

Query: 460  KAVSLSVTVPVSHPV-----LTLSSAEALTFEGATVTLHCEVQ-RGSPQILYQFYHEDMP 513
              V+ +    +++P      + +  + +   EG T+ L+C V  +   Q+ +      +P
Sbjct: 2323 VTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP 2382

Query: 514  LWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFV---TVPVSRPILTL 570
            +   +  S+ R+   +  +   SG Y C       P  + V+       +VP      T+
Sbjct: 2383 VRHQTHGSLLRL---YQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTV 2439

Query: 571  RV--PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEH 628
            R+    +Q   G  L+L+C     +   + W +    +L +     G      L +T   
Sbjct: 2440 RIESSSSQVAEGQTLDLNCLVAGQAHAQVTW-HKRGGSLPARHQVHGSRLRL-LQVTPAD 2497

Query: 629  SGNYSCEANNGLVAQHSDTISLSVIVPVSRPI-----------LTFRAPRAQAVVGDLLE 677
            SG Y C      V   S T   SV+V + + +           +   +  A    G  L+
Sbjct: 2498 SGEYVCR-----VVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552

Query: 678  LHCEALRGSSPILYWFYHEDVTLGKISAPSGG---GASFNL-SLTTEHSGIYSCEADNGL 733
            L+C     +   + W+          S PS     G+   +  +T   SG Y C   NG 
Sbjct: 2553 LNCLVASQAPHTITWYKRGG------SLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606

Query: 734  EAQRSEM-VTLKVA----VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFH 788
             ++ + + VT++ +    VP   P + + +       G  L+L+C   R  P  +  ++ 
Sbjct: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAR-QPQAIITWYK 2665

Query: 789  EDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETV 833
               +L +R    G       ++   SG Y C A+N + A  +  V
Sbjct: 2666 RGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIV 2710



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 150/669 (22%), Positives = 251/669 (37%), Gaps = 79/669 (11%)

Query: 149  TDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVL------RASSFQPI 202
            ++ H P     D G Y CT    +    +++  ++ V E  ++P+       R+ S +P 
Sbjct: 1729 SELHFPSVQPSDAGVYICTC--RNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRP- 1785

Query: 203  SGNPVTLTCETQLS----------LERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS 252
             G  VT  C  +            L    +P R   F    T+        N Q++    
Sbjct: 1786 -GADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIR-------NVQLS---- 1833

Query: 253  KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312
             D+G Y C  + M +++   +    +Q     S PV+++ P +     G      C    
Sbjct: 1834 -DAGTYVCTGSNM-FAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATG 1891

Query: 313  DSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLS 372
                TL      G  L  K+ +   G     ++   +   Y C A +  G + ++AV L 
Sbjct: 1892 SPTPTLEWTGGPGGQLPAKA-QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAV-LH 1949

Query: 373  VTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGV 432
            V      P + +S     +  G  V L+C A  G       +  EG +L  ++ +    +
Sbjct: 1950 VHGG-GGPRVQVSPERTQVHAGRTVRLYCRAA-GVPSATITWRKEGGSLPPQARSERTDI 2007

Query: 433  AISF--SLTAEHSGNYYCTADN--GFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGA 488
            A     ++T   +G Y C A +  G    R + V LS +     PV   SS+ ++T EG 
Sbjct: 2008 ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT-EGQ 2066

Query: 489  TVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFG 548
            T+ L+C V  GS      +Y     L   +     R+     ++   SG Y C  +NG G
Sbjct: 2067 TLDLNCVVA-GSAHAQVTWYRRGGSLPPHTQVHGSRLRLP-QVSPADSGEYVCRVENGSG 2124

Query: 549  PQRSEV-VSL---------FVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY 598
            P+ + + VS+         +  VP S   + +    +    G  L+L+C  P  +   + 
Sbjct: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184

Query: 599  WFYHEDVTLGSSSAPSGGEASFNL----SLTAEHSGNYSCE---ANNGLVAQHSDTISLS 651
            W           S P+  +   +L     +T   SG Y C     +  L A    TI  S
Sbjct: 2185 WHKR------GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238

Query: 652  VIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISA--PSGG 709
            VI P   P +   +  +    G  L+L C     +   + W+       G + A     G
Sbjct: 2239 VI-PGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG----GSLPARHQVRG 2293

Query: 710  GASFNLSLTTEHSGIYSCEADNGLEAQRSEMVT----LKVAVPV-SRPVLTLRAPGTHAA 764
               +    +   +G Y C A NG+EA  +  VT      +A P  S   + +    +  A
Sbjct: 2294 SRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA 2353

Query: 765  VGDLLELHC 773
             G  L+L+C
Sbjct: 2354 EGQTLDLNC 2362



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 190/868 (21%), Positives = 299/868 (34%), Gaps = 110/868 (12%)

Query: 23   PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQE--- 79
            P I ++P  + V +G+ + L C        Q T W+ R        +    +L + +   
Sbjct: 2827 PPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT-WHKRGGNLPARHQVHGPLLRLNQVSP 2885

Query: 80   --SGEYRCQAQGSP-----------------------LSSPVHLDFSSASLILQAPLSVF 114
              SGEY CQ  GS                        L+ P++++ SS+         V 
Sbjct: 2886 ADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH--------VT 2937

Query: 115  EGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKR--TDFHIPHACLKDNGAYRCTGYKES 172
            EG ++ L C    +     T YK    L   ++   +   +      D+G Y C      
Sbjct: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRA---- 2993

Query: 173  CCPVSSNTVKIQVQEPFTRPVLRASSFQ----PISGNPVTLTCET------QLSLERSDV 222
                S    + +     T P    SS++     IS +P + T +       +  +     
Sbjct: 2994 ---ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA 3050

Query: 223  PLRFRFFRDDQTLGLGWSLSPNFQI-TAMWSKDS--GFYWCKAATMPYSVISDSPRSWIQ 279
            P+   +   +Q L     +SPN  I T + ++ S  G Y C A+   Y V     +S + 
Sbjct: 3051 PISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNA-YGVA----QSVVN 3105

Query: 280  VQIPASHPVLTLSPEKALNFE-GTKVTLHC----ETQEDSLRTLYRFYHEGVPLRHKSVR 334
            + +    P +++ PE  +  + G  VTL C    E +  +  T        +  R   + 
Sbjct: 3106 LSVHGP-PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLM 3164

Query: 335  CERGASISFSLTTENSGNYYCTADNGLGA--KPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392
                     S    ++G Y C A N LG   K  + +  +  +    P +     E  + 
Sbjct: 3165 DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE 3224

Query: 393  EGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADN 452
             G   TL C A     P ++          +      G   I   +  + SG Y C A +
Sbjct: 3225 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE--GDTLIIPRVAQQDSGQYICNATS 3282

Query: 453  GFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDM 512
              G   +  + L V  P   P  T     A    G TV L C +  G+P + +Q+     
Sbjct: 3283 PAGHAEATII-LHVESP---PYATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGS 3337

Query: 513  PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTL-- 570
             L   +T     + F  +  E  SG Y C   N  G   +    L    P S P  ++  
Sbjct: 3338 SLPGRATARNELLHFERAAPED-SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPA 3396

Query: 571  -RVPRAQAV-------VGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL 622
               P  Q         +G  +E HC  P      L WF          S   G     NL
Sbjct: 3397 GSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNL 3456

Query: 623  SLTAEHSGNYSCEANNGL-VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681
              + +  G Y C+A+     AQ S  + +  +  V   ++  R      VVG  +E  C 
Sbjct: 3457 DQSCQ--GTYICQAHGPWGKAQASAQLVIQALPSV---LINIRTSVQTVVVGHAVEFECL 3511

Query: 682  ALRGSSPILYWFYHEDVTLGKISAPS---GGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738
            AL    P + W       +G    P     GG      +    +G Y C A N     +S
Sbjct: 3512 ALGDPKPQVTWS-----KVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQS 3566

Query: 739  EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS 798
             ++ L  A+P       +R P   AAV       C A  G P     +   D +L   S 
Sbjct: 3567 HVLLLVQALPQISMPQEVRVPAGSAAV-----FPCIA-SGYPTPDISWSKLDGSLPPDSR 3620

Query: 799  PSGGASLNLSLTAEHSGNYSCEADNGLG 826
                  +  S+  + +G Y C A N  G
Sbjct: 3621 LENNMLMLPSVRPQDAGTYVCTATNRQG 3648



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 155/719 (21%), Positives = 258/719 (35%), Gaps = 72/719 (10%)

Query: 162  GAYRCTG--------YKESCCPVSSNTVKIQV--------QEPFTRPVLRASSFQPISGN 205
            G YRCT         Y E C P       +Q         Q P    V  A S  P  G+
Sbjct: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693

Query: 206  PVTLTCETQLSLERSDVPLRFRFFRDD-QTLGLGWSL---SPNFQITAMWSKDSGFYWCK 261
              +L C+   S      P  F + R+D + +  G             ++   D+G Y C 
Sbjct: 1694 H-SLRCQVSGS-----PPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICT 1747

Query: 262  AATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE-GTKVTLHCETQEDS--LRTL 318
               +  S  + S    +  + P+    +T+  +++ +   G  VT  C  +  S     +
Sbjct: 1748 CRNLHQS--NTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805

Query: 319  YRFYHEG-VPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKA-VSLSVTVP 376
            +   H G +P R        G     ++   ++G Y CT  N        A + +  +  
Sbjct: 1806 WTRLHNGKLPTRAMDFN---GILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGT 1862

Query: 377  VSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISF 436
            +S PV+++  P+  +  G      C A     P L      G  L  + A   GG+    
Sbjct: 1863 LSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAK-AQIHGGILRLP 1921

Query: 437  SLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEV 496
            ++       Y C A +  G Q ++AV L V      P + +S        G TV L+C  
Sbjct: 1922 AVEPTDQAQYLCRAHSSAGQQVARAV-LHVHGG-GGPRVQVSPERTQVHAGRTVRLYCRA 1979

Query: 497  QRGSPQILYQFYHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV 554
              G P     +  E   +P  + S  +        ++T   +G Y C A +  G  ++ +
Sbjct: 1980 A-GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARI 2038

Query: 555  -VSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP 613
             V +      S P + +         G  L+L+C     +   + W+       G S  P
Sbjct: 2039 QVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR-----GGSLPP 2093

Query: 614  SGGEASFNLSL---TAEHSGNYSCEANNGLVAQHSDTISLSVI-----------VPVSRP 659
                    L L   +   SG Y C   NG   + + +I++SV+           VP S  
Sbjct: 2094 HTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEA-SITVSVLHGTHSGPSYTPVPGSTR 2152

Query: 660  ILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTT 719
             +      +    G  L+L+C  + G +     ++    +L       G     +  +T 
Sbjct: 2153 PIRIEPSSSHVAEGQTLDLNC-VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLH-QVTP 2210

Query: 720  EHSGIYSCEA---DNGLEAQRSEMVTLKVAV-PVSRPVLTLRAPGTHAAVGDLLELHCEA 775
              SG Y C        LEA  S +VT++ +V P   P + + +  +  A G  L+L C  
Sbjct: 2211 ADSGEYVCHVVGTSGPLEA--SVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC-V 2267

Query: 776  LRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVT 834
            + G       ++    +L  R    G        +   +G Y C A NG+ A  + TVT
Sbjct: 2268 VAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVT 2326



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 158/695 (22%), Positives = 242/695 (34%), Gaps = 120/695 (17%)

Query: 8    LVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEIL 67
            + + P  G   R   P+I + PP +TV QG+  +  C      +P   +W  R       
Sbjct: 3007 VTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN------ 3060

Query: 68   RETPDNI-------------LEVQESGEYRCQAQGS--PLSSPVHLDFS---SASLILQA 109
            +E  DN+                   G YRC A  +     S V+L      + S++ + 
Sbjct: 3061 QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG 3120

Query: 110  PLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRT----DFH----IPHACLKDN 161
            P+ V  G +V L C +  E   +    +  +  A L +RT    D H    I  A   D 
Sbjct: 3121 PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA 3180

Query: 162  GAYRCTGYKESCCPVSSNTVKIQVQEPFTRP-----VLRASSFQPISGNPVTLTCET--- 213
            G Y C    ++    +   V++ V      P         +     +G+  TL C     
Sbjct: 3181 GTYVCLA--QNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGS 3238

Query: 214  -----QLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYS 268
                   S  RS +P + R   D               I  +  +DSG Y C A      
Sbjct: 3239 PAPTIHWSKLRSPLPWQHRLEGD------------TLIIPRVAQQDSGQYICNAT----- 3281

Query: 269  VISDSPRSWIQVQI---PASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG 325
                SP    +  I     S P  T  PE A    G  V L C        T +++   G
Sbjct: 3282 ----SPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLT-FQWSRVG 3336

Query: 326  VPL------RHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH 379
              L      R++ +  ER A        E+SG Y C   N +G+  + A  L    P S 
Sbjct: 3337 SSLPGRATARNELLHFERAAP-------EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3389

Query: 380  PVLNL---SSPEDLIFE-------GAKVTLHCE--AQRGSLPILYQFHHEGAALERRSAN 427
            P  ++   S+P   +         GA V  HC   + RG+     ++  EG  L    + 
Sbjct: 3390 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQ---LRWFKEGGQLPPGHSV 3446

Query: 428  SAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEG 487
              G + I  +L     G Y C A   +G  ++ A  +   +P    ++ + ++      G
Sbjct: 3447 QDGVLRIQ-NLDQSCQGTYICQAHGPWGKAQASAQLVIQALP--SVLINIRTSVQTVVVG 3503

Query: 488  ATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGF 547
              V   C +  G P+    +      L      S G V  +  +    +G Y CTA N  
Sbjct: 3504 HAVEFEC-LALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAH-VELADAGQYRCTATNAA 3561

Query: 548  GPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTL 607
            G  +S V+ L   +P       +RVP   A V       C A     P + W      + 
Sbjct: 3562 GTTQSHVLLLVQALPQISMPQEVRVPAGSAAV-----FPCIASGYPTPDISW------SK 3610

Query: 608  GSSSAPSGGEASFNL----SLTAEHSGNYSCEANN 638
               S P       N+    S+  + +G Y C A N
Sbjct: 3611 LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATN 3645



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 114/506 (22%), Positives = 184/506 (36%), Gaps = 66/506 (13%)

Query: 436  FSLTAEH--SGNYYCTADN-----------GFGPQRSKAVSLSVTVPVSHP---VLTLSS 479
            FS T E   +G Y CTA             G G   + +V     +P ++    V+ +  
Sbjct: 1624 FSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHP 1683

Query: 480  AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF-SLTEGHSGN 538
            A ++  +G + +L C+V    P   Y    +  P+ S +          F S+    +G 
Sbjct: 1684 ARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGV 1743

Query: 539  YYCTADNGFGPQRSEVVSLFVTVPVSRPI-LTLRVPRAQAV-VGDLLELHCEAPRGSPPI 596
            Y CT  N      S    L VT   S+PI +T+   R+Q+V  G  +   C A   SP  
Sbjct: 1744 YICTCRNLHQSNTSRA-ELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAY 1802

Query: 597  -LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVA-QHSDTISLSVIV 654
             L W    +  L + +    G  +   ++    +G Y C  +N     Q + T+ +    
Sbjct: 1803 TLVWTRLHNGKLPTRAMDFNGILTIR-NVQLSDAGTYVCTGSNMFAMDQGTATLHVQASG 1861

Query: 655  PVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFN 714
             +S P+++   P+     G L E  C A    +P L W       L   +   GG     
Sbjct: 1862 TLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLP 1921

Query: 715  LSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPG----------THAA 764
                T+ +  Y C A +    Q            V+R VL +   G          T   
Sbjct: 1922 AVEPTDQAQ-YLCRAHSSAGQQ------------VARAVLHVHGGGGPRVQVSPERTQVH 1968

Query: 765  VGDLLELHCEALR-GSPLILYRFFHEDVTLGNRSSPSGGASLNL-SLTAEHSGNYSCEAD 822
             G  + L+C A    S  I +R     +    RS  +  A+L + ++T   +G Y C A 
Sbjct: 1969 AGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVAT 2028

Query: 823  NGLGAQRSETVTLYITGLTAN-------RSGPFATGVAGGLLSIAGLAAGALLLYCWLSR 875
            +  G  ++    + ++   A+        S P  T   G  L +  + AG+        R
Sbjct: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT--EGQTLDLNCVVAGSAHAQVTWYR 2086

Query: 876  KAGRKPASD---------PARSPSDS 892
            + G  P            P  SP+DS
Sbjct: 2087 RGGSLPPHTQVHGSRLRLPQVSPADS 2112


>gi|189083840 Fc fragment of IgG, low affinity IIIa, receptor
           (CD16a) isoform c precursor [Homo sapiens]
          Length = 254

 Score =  107 bits (266), Expect = 7e-23
 Identities = 89/269 (33%), Positives = 127/269 (47%), Gaps = 31/269 (11%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58
           +LL   LL+L     +    P+ ++FL+P W  V + + VTL C+G   YSP+   T+W+
Sbjct: 4   LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQWF 61

Query: 59  HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114
           H    + ++     +       V +SGEYRCQ   S LS PV L+     L+LQAP  VF
Sbjct: 62  H---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 118

Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172
            E D + LRC +     L+   Y +N     + +  +DF+IP A LKD+G+Y C G   S
Sbjct: 119 KEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGS 178

Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232
              VSS TV I + +     V   SSF P  G  V+  C   + L   D           
Sbjct: 179 -KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT---------- 223

Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWCK 261
              GL +S+  N + +    KD  F W K
Sbjct: 224 ---GLYFSVKTNIRSSTRDWKDHKFKWRK 249



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 18/181 (9%)

Query: 113 VFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171
           V E DSV L+C+       N+T  + N+++++  ++ + + I  A + D+G YRC    +
Sbjct: 37  VLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQASSYFIDAATVDDSGEYRC----Q 90

Query: 172 SCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD 231
           +     S+ V+++V   +   +L+A  +     +P+ L C +  +     V      +  
Sbjct: 91  TNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVT-----YLQ 143

Query: 232 DQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291
           +      +  + +F I     KDSG Y+C+      +V S++    + + I     V T+
Sbjct: 144 NGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSET----VNITITQGLAVSTI 199

Query: 292 S 292
           S
Sbjct: 200 S 200


>gi|189083838 Fc fragment of IgG, low affinity IIIa, receptor
           (CD16a) isoform c precursor [Homo sapiens]
          Length = 254

 Score =  107 bits (266), Expect = 7e-23
 Identities = 89/269 (33%), Positives = 127/269 (47%), Gaps = 31/269 (11%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58
           +LL   LL+L     +    P+ ++FL+P W  V + + VTL C+G   YSP+   T+W+
Sbjct: 4   LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQWF 61

Query: 59  HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114
           H    + ++     +       V +SGEYRCQ   S LS PV L+     L+LQAP  VF
Sbjct: 62  H---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 118

Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172
            E D + LRC +     L+   Y +N     + +  +DF+IP A LKD+G+Y C G   S
Sbjct: 119 KEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGS 178

Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232
              VSS TV I + +     V   SSF P  G  V+  C   + L   D           
Sbjct: 179 -KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT---------- 223

Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWCK 261
              GL +S+  N + +    KD  F W K
Sbjct: 224 ---GLYFSVKTNIRSSTRDWKDHKFKWRK 249



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 18/181 (9%)

Query: 113 VFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171
           V E DSV L+C+       N+T  + N+++++  ++ + + I  A + D+G YRC    +
Sbjct: 37  VLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQASSYFIDAATVDDSGEYRC----Q 90

Query: 172 SCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD 231
           +     S+ V+++V   +   +L+A  +     +P+ L C +  +     V      +  
Sbjct: 91  TNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVT-----YLQ 143

Query: 232 DQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291
           +      +  + +F I     KDSG Y+C+      +V S++    + + I     V T+
Sbjct: 144 NGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSET----VNITITQGLAVSTI 199

Query: 292 S 292
           S
Sbjct: 200 S 200


>gi|189083836 Fc fragment of IgG, low affinity IIIa, receptor
           (CD16a) isoform b precursor [Homo sapiens]
          Length = 289

 Score =  107 bits (266), Expect = 7e-23
 Identities = 89/272 (32%), Positives = 129/272 (47%), Gaps = 35/272 (12%)

Query: 2   LLWVILL----VLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KT 55
           ++W +LL    +L   +G     P+ ++FL+P W  V + + VTL C+G   YSP+   T
Sbjct: 36  IMWQLLLPTALLLLVSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNST 93

Query: 56  KWYHRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPL 111
           +W+H    + ++     +       V +SGEYRCQ   S LS PV L+     L+LQAP 
Sbjct: 94  QWFH---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPR 150

Query: 112 SVF-EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGY 169
            VF E D + LRC +     L+   Y +N     + +  +DF+IP A LKD+G+Y C G 
Sbjct: 151 WVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGL 210

Query: 170 KESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFF 229
             S   VSS TV I + +     V   SSF P  G  V+  C   + L   D        
Sbjct: 211 FGS-KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT------- 258

Query: 230 RDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK 261
                 GL +S+  N + +    KD  F W K
Sbjct: 259 ------GLYFSVKTNIRSSTRDWKDHKFKWRK 284



 Score = 33.5 bits (75), Expect = 1.00
 Identities = 44/203 (21%), Positives = 91/203 (44%), Gaps = 19/203 (9%)

Query: 92  LSSPVHLDFSSASLILQAP-LSVFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRT 149
           +S+ +  D   A + L+     V E DSV L+C+       N+T  + N+++++  ++ +
Sbjct: 50  VSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQAS 107

Query: 150 DFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTL 209
            + I  A + D+G YRC    ++     S+ V+++V   +   +L+A  +     +P+ L
Sbjct: 108 SYFIDAATVDDSGEYRC----QTNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHL 161

Query: 210 TCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSV 269
            C +  +     V      +  +      +  + +F I     KDSG Y+C+      +V
Sbjct: 162 RCHSWKNTALHKVT-----YLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNV 216

Query: 270 ISDSPRSWIQVQIPASHPVLTLS 292
            S++    + + I     V T+S
Sbjct: 217 SSET----VNITITQGLAVSTIS 235


>gi|50726979 Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
           isoform a precursor [Homo sapiens]
          Length = 290

 Score =  107 bits (266), Expect = 7e-23
 Identities = 89/269 (33%), Positives = 127/269 (47%), Gaps = 31/269 (11%)

Query: 1   MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58
           +LL   LL+L     +    P+ ++FL+P W  V + + VTL C+G   YSP+   T+W+
Sbjct: 40  LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQWF 97

Query: 59  HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114
           H    + ++     +       V +SGEYRCQ   S LS PV L+     L+LQAP  VF
Sbjct: 98  H---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 154

Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172
            E D + LRC +     L+   Y +N     + +  +DF+IP A LKD+G+Y C G   S
Sbjct: 155 KEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGS 214

Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232
              VSS TV I + +     V   SSF P  G  V+  C   + L   D           
Sbjct: 215 -KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT---------- 259

Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWCK 261
              GL +S+  N + +    KD  F W K
Sbjct: 260 ---GLYFSVKTNIRSSTRDWKDHKFKWRK 285



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 18/181 (9%)

Query: 113 VFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171
           V E DSV L+C+       N+T  + N+++++  ++ + + I  A + D+G YRC    +
Sbjct: 73  VLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQASSYFIDAATVDDSGEYRC----Q 126

Query: 172 SCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD 231
           +     S+ V+++V   +   +L+A  +     +P+ L C +  +     V      +  
Sbjct: 127 TNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVT-----YLQ 179

Query: 232 DQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291
           +      +  + +F I     KDSG Y+C+      +V S++    + + I     V T+
Sbjct: 180 NGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSET----VNITITQGLAVSTI 235

Query: 292 S 292
           S
Sbjct: 236 S 236


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  107 bits (266), Expect = 7e-23
 Identities = 197/818 (24%), Positives = 319/818 (38%), Gaps = 121/818 (14%)

Query: 74   ILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSV-----------FEGDSVVLR 122
            +L V+++G Y C A+     SP      S  + +QAP ++                +VL 
Sbjct: 2357 VLRVRDAGLYTCLAE-----SPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE 2411

Query: 123  CRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV 176
            C  +AE     T +++  VL       F  +     +      D+G Y CT    +    
Sbjct: 2412 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA---- 2467

Query: 177  SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL---ERSDVPLRFRFFRDDQ 233
             S +V  +V E  T P +R       SG P       Q +L   +   VP     +R D+
Sbjct: 2468 GSTSVAFRV-EIHTVPTIR-------SGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 2519

Query: 234  T----LGLGWSLSP--NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP 287
                     + + P  + +I  + ++D+G Y C A+    S  SD     ++V  P   P
Sbjct: 2520 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN---SAGSDRQGRDLRVLEP---P 2573

Query: 288  VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGA-----SIS 342
             +  SP        T   L CE    S + L  ++ +G  L     R ++GA     S +
Sbjct: 2574 AIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKL---DFRLQQGAYRLLPSNA 2629

Query: 343  FSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399
              LT    ++S  + C   N +G +  +   ++V VP   P +     +  +   A V L
Sbjct: 2630 LLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVHVP---PTIADDQTDFTVTMMAPVVL 2685

Query: 400  HCEAQRGSLPILYQFHHEGAALERRSA----NSAGGVAISFSLTAEHSGNYYCTADNGFG 455
             C +     P +  +   GA L  R +    + +G + I  +L   H+G Y C+A N  G
Sbjct: 2686 TCHSTGIPAPTV-SWSKAGAQLGARGSGYRVSPSGALEIGQALPI-HAGRYTCSARNSAG 2743

Query: 456  PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515
                         PV  P+ ++  A A       V L CE   G P+    +  E + + 
Sbjct: 2744 VAHKHVFLTVQASPVVKPLPSVVRAVA----EEEVLLPCEAS-GIPRPTITWQKEGLNVA 2798

Query: 516  SSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572
            +  +  V   G++  + +  E  +GNY C A N  G    +   L V VP   P++   +
Sbjct: 2799 TGVSTQVLPGGQLRIAHASPED-AGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGL 2853

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-SGGEASFNL--------- 622
            P      G    L C+A RGSP         ++T      P SG E  F +         
Sbjct: 2854 PDLSTTEGSHAFLPCKA-RGSP-------EPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2905

Query: 623  SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
            +L  + +G Y+C A N  V +    + L+++V    P+ T         +GD L L C A
Sbjct: 2906 NLEGQDAGTYTCTAENA-VGRARRRVHLTILV---LPVFTTLPGDRSLRLGDRLWLRCAA 2961

Query: 683  LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL-EAQRSEMV 741
                +P + W  ++      +S   GG      +++ E SG Y C A+N +   Q    V
Sbjct: 2962 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021

Query: 742  TLKVAVPVSRPVLTLRA-PGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800
             +K A     PVL   A       VG  ++L C  +RG P+    +  + + L  R S  
Sbjct: 3022 HVKEA-----PVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDIHWIKDGLPL--RGSHL 3073

Query: 801  GGASLNLSLT-----AEHSGNYSCEADNGLGAQRSETV 833
                 N SLT      + +G Y C A+N +G  +   +
Sbjct: 3074 RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVI 3111



 Score =  106 bits (264), Expect = 1e-22
 Identities = 207/857 (24%), Positives = 326/857 (38%), Gaps = 83/857 (9%)

Query: 19   RTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY----LGKEILRETPDNI 74
            + P  I  L     T      V+L C      +P+ T WY       LG+E+      + 
Sbjct: 1743 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT-WYKDSQALSLGEEVFLLPGTHT 1801

Query: 75   LEV-----QESGEYRCQAQGSP--------LSSPVHLDFSSASLILQAPLSVFEGDSVVL 121
            L++      +SG Y C+A  +         LS  V   F  A    Q  + V  GD  VL
Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1861

Query: 122  RCRAKAEVTLNNTIYKNDNVLAFLNKRTD-------FHIPHACLKDNGAYRCTGYKESCC 174
             C   A      T YK+   L  L +RT          I  A + D G Y C     +  
Sbjct: 1862 SCETDALPEPTVTWYKDGQPLV-LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1920

Query: 175  PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
             V + T+ +QV   F  P  +  +   ++G+P+ LTC+       +   L+ R   +   
Sbjct: 1921 AVRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA 1978

Query: 235  LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294
            +    S     Q++ +    +G Y C A     +  +++ + ++   + A     +    
Sbjct: 1979 VHGVVSRGGRLQLSRLQPAQAGTYTCVAE----NTQAEARKDFVVAVLVAPRIRSSGVAR 2034

Query: 295  KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-----RHKSVRCERGASISFSLTTEN 349
            +    EG +V L CE        +  +  +G PL      H     + G+ +   L   +
Sbjct: 2035 EHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2093

Query: 350  SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLP 409
            +G Y C A N  G + ++  +++V VP +       S   +   G  VT+ C   RGS P
Sbjct: 2094 AGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPP 2151

Query: 410  ILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466
            I   +  +G  L   +R   + +G       +    +G + C A +  G    +  +L V
Sbjct: 2152 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQV 2210

Query: 467  TV-PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRV 525
             V PV  PV   +  + +   G+ V L CE  RG P  L  +  +  PL S S      +
Sbjct: 2211 QVPPVLEPVEFQN--DVVVVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLEQGPSL 2267

Query: 526  SFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV-GDLLE 584
                ++  G SG Y C A +  G  R       +TV     I     P   ++  G  +E
Sbjct: 2268 QLE-AVGAGDSGTYSCVAVSEAGEARRH---FQLTVMEPPHIEDSGQPTELSLTPGAPME 2323

Query: 585  LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644
            L C+A     P + W  H+D   G +       +     L    +G Y+C     L    
Sbjct: 2324 LLCDAQGTPQPNITW--HKD---GQALTRLENNSRATRVLRVRDAGLYTC-----LAESP 2373

Query: 645  SDTISLSVIVPVSRP--ILTFRAPR-AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701
            +  I  S  V V  P  I+  R PR    +    L L C      +P + W  H D  + 
Sbjct: 2374 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW--HRDGIVL 2431

Query: 702  KISA----PSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757
            +  A    P  G      +L+T  SG YSC A N   A  S  V  +V +  + P +   
Sbjct: 2432 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARN---AAGSTSVAFRVEIH-TVPTIRSG 2487

Query: 758  APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLTAE 812
             P  + +V     L C+A  G P  L  +  + V L  RS      P G   +   + A+
Sbjct: 2488 PPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ-PVLAQ 2545

Query: 813  HSGNYSCEADNGLGAQR 829
             +G+Y C A N  G+ R
Sbjct: 2546 DAGHYLCLASNSAGSDR 2562



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 213/899 (23%), Positives = 324/899 (36%), Gaps = 141/899 (15%)

Query: 34   VFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRE-----TPDNIL------EVQESGE 82
            V  G+   L C       P+ T W+    G+ + R      +PD +L       +  +G 
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLT-WFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGH 1322

Query: 83   YRCQAQGSPLSSPVHLDFSSASLILQAP-------------LSVFEGDSVVLRCRAKAEV 129
            Y C A  +      H   S    +L AP             ++V   + + L C A A  
Sbjct: 1323 YSCIAANAVGEKTKHFQLS----VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 1378

Query: 130  TLNNTIYKN------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
            + N T  K+         +  L       I +A  +D G Y C    E    V +  V++
Sbjct: 1379 SPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1438

Query: 184  QVQEPFTRP----VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ------ 233
             +    ++      +     +    + +TL CE+      +  P   R+++D Q      
Sbjct: 1439 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW-----AVPPPTIRWYKDGQPVTPSS 1493

Query: 234  ---TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQV-QIP 283
                LG G  L    QI      DSG Y C A  +       ++V+   P  + +V    
Sbjct: 1494 RLQVLGEGRLL----QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 1549

Query: 284  ASHPVLTLSPEKALNF-------EGTKVTLHCETQEDSLRTLYRFYHEGVPLR---HKSV 333
            A+  +L+   E            E     L+C+T       L  +Y E  PL      SV
Sbjct: 1550 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSV 1608

Query: 334  RCERGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392
              + G  +   L   EN+G Y C A N +G        L +T PV      L   E+L+ 
Sbjct: 1609 -LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-----LGDTEELVE 1662

Query: 393  E-----GAKVTLHCEAQRGSLPILYQFHH--EGAALERRSANSAGGVAISFSLTAEHSGN 445
            E      + V+L C A    +P +    +    +   R      G V    +     + +
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1722

Query: 446  YYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSPQIL 504
            Y C A+N  G    K  +L V VP     L L    A+    ++V+L C+V    +P++ 
Sbjct: 1723 YMCVAENQAG-SAEKLFTLRVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 1779

Query: 505  Y-------QFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSL 557
            +           E   L  + T  +GR   S       SG Y C A N  G +  ++V L
Sbjct: 1780 WYKDSQALSLGEEVFLLPGTHTLQLGRARLS------DSGMYTCEALNAAG-RDQKLVQL 1832

Query: 558  FVTVPVSRPILTLRVPRA--QAV---VGDLLELHCEAPRGSPPILYWFYHED--VTLGSS 610
             V VP +      + PR    AV   VGD   L CE      P + W+      V    +
Sbjct: 1833 SVLVPPA----FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 1888

Query: 611  SAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQA 670
             A  GG+            G YSC+ +N +  +   T +L+V VP      TF  P+ + 
Sbjct: 1889 QALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTVQVPP-----TFENPKTET 1942

Query: 671  ---VVGDLLELHCEALRGSSPILYWFYHE-DVTLGKISAPSGGGASFNLS-LTTEHSGIY 725
               V G  L L C+     +P + W      V    +      G    LS L    +G Y
Sbjct: 1943 VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTY 2002

Query: 726  SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785
            +C A+N     R + V   +  P  R     R    H   G  + L CEA  G P     
Sbjct: 2003 TCVAENTQAEARKDFVVAVLVAPRIRSSGVARE--HHVLEGQEVRLDCEA-DGQPPPDVA 2059

Query: 786  FFHEDVTLGNRSSP------SGGASLNLSLTAEHSGNYSCEADNGLGAQ-RSETVTLYI 837
            +  +   LG    P       GG+ +   L A  +G Y+C A N  G   R  TV + +
Sbjct: 2060 WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 2118



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 203/898 (22%), Positives = 328/898 (36%), Gaps = 136/898 (15%)

Query: 40   VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNIL------------EVQESGEYRCQA 87
            +TL C+      P   +W+    G+E +    D  L            + Q+SG Y C A
Sbjct: 1179 LTLLCEAMGI-PPPAIRWFR---GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1234

Query: 88   QGSPLSSPVHLDFSSASLI--------LQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKND 139
                 +     +FS   L+        L+  + V +G +  L C          T +K+ 
Sbjct: 1235 SNE--AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 1292

Query: 140  NVLAFLNKRTDFH----------IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPF 189
              LA    R D H          +  A L   G Y C         V   T   Q+    
Sbjct: 1293 RPLA----RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLL 1344

Query: 190  TRPVLRA---SSFQPIS---GNPVTLTCET------QLSLERSDVPLRFRFFRDDQTLGL 237
               +L     S+ + ++    NP++L CE        ++  +   P  F   R+ Q L  
Sbjct: 1345 APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPG 1402

Query: 238  GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPAS----HPVLTLS 292
               L    QI     +D+G Y C       + + ++ +++ ++V IP S     P+  + 
Sbjct: 1403 THGL----QILNAQKEDAGQYTCVVT----NELGEAVKNYHVEVLIPPSISKDDPLGEVG 1454

Query: 293  PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLT---TEN 349
             ++      + +TL CE+      T+ R+Y +G P+   S     G      +      +
Sbjct: 1455 VKEVKTKVNSTLTLECESWAVPPPTI-RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSD 1513

Query: 350  SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------------IFE 393
            SG Y C A N  G        L    P+   V + S+  ++                I E
Sbjct: 1514 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 1573

Query: 394  GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAEHSGNYYCTAD 451
                 L+C+      P L  +  +   +A +  S    G V     + AE++G Y C A 
Sbjct: 1574 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1633

Query: 452  NGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFE-----GATVTLHCEVQRGSPQILYQ 506
            N  G        L +T PV      L   E L  E      +TV+L C    G+P     
Sbjct: 1634 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTIS 1687

Query: 507  FYHEDMPLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPV 563
            +    +P   S    V   G+V    +     + +Y C A+N  G    ++ +L V VP 
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG-SAEKLFTLRVQVPP 1746

Query: 564  SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHED-VTLGSSSAPSGGEASFNL 622
               I  L + +  A++   + L C+      P + W+     ++LG       G  +  L
Sbjct: 1747 R--IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 1804

Query: 623  SLTA-EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR-APRA--QAV---VGDL 675
                   SG Y+CEA N    +    + LSV+VP +     FR APR    AV   VGD 
Sbjct: 1805 GRARLSDSGMYTCEALNA-AGRDQKLVQLSVLVPPA-----FRQAPRGPQDAVLVRVGDK 1858

Query: 676  LELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLS-LTTEHSGIYSCEADNGL 733
              L CE      P + W+   + + L + +    GG    +        G+YSC+  N  
Sbjct: 1859 AVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVA 1918

Query: 734  -EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
             EA R+  +T++V      P    +        G  L L C+ + G P     +  + + 
Sbjct: 1919 GEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCD-VSGVPAPTVTWLKDRMP 1973

Query: 793  LGNRSSP---SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSG 846
            + + +     S G  L LS L    +G Y+C A+N     R + V   +       SG
Sbjct: 1974 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG 2031



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 102/392 (26%), Positives = 160/392 (40%), Gaps = 27/392 (6%)

Query: 348  ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
            E++GNY C A N  G+   K   L V VP   PV+    P+    EG+   L C+A RGS
Sbjct: 2819 EDAGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGLPDLSTTEGSHAFLPCKA-RGS 2873

Query: 408  LPILYQFHHEG---AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464
                  +  +G   +  E +      G  +  +L  + +G Y CTA+N  G  R + V L
Sbjct: 2874 PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR-VHL 2932

Query: 465  SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGR 524
            ++ V    PV T    +     G  + L C   RGSP     +   D P+    +   G 
Sbjct: 2933 TILVL---PVFTTLPGDRSLRLGDRLWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDGG 2988

Query: 525  VSFS-FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583
             +    +++   SG Y C A+N  G  R++ VS FV V  +  +           VG  +
Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVG--RTQAVS-FVHVKEAPVLQGEAFSYLVEPVGGSI 3045

Query: 584  ELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGL- 640
            +L C   RG P P ++W        GS         S  +  T  + +G Y C A N + 
Sbjct: 3046 QLDCVV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMG 3104

Query: 641  VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFY-HEDVT 699
            VA+      + ++V  S P+            GD + L C+A    +P + W    + + 
Sbjct: 3105 VAK-----KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR 3159

Query: 700  LGKISAPSGGGASFNLSLTTEHSGIYSCEADN 731
              +       G+ +  ++ T  +G Y C A N
Sbjct: 3160 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3191



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 211/869 (24%), Positives = 301/869 (34%), Gaps = 122/869 (14%)

Query: 37   GERVTLTCKGFRFYSPQKTKWYHRYL----GKEILRETPDNILEVQESGEYRCQAQGSPL 92
            G  V L C      SP  + W+H  L      E   ET  ++L ++  GE          
Sbjct: 420  GRPVALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478

Query: 93   SSPVHLDFSSASLILQAP-----------LSVFEGDSVVLRCRAKAEVTLNNTIYKNDNV 141
            SSP        S+ +Q P           ++   G  + L C+A           +N   
Sbjct: 479  SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538

Query: 142  LAFL------NKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLR 195
               L      ++ T  HI H  L  +G + C    E+    +   V++ V   +   VL 
Sbjct: 539  AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA--GTAGAEVEVSVHGEWAPGVLE 596

Query: 196  ASSFQPISG----NPVTLTCETQLSLERSDVPLR---------FRFFRDDQTLGLGWSLS 242
                Q   G    +     C+  +       P              + +   + + +SL 
Sbjct: 597  VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 656

Query: 243  PNFQITAMWSKDSGFYWCKAATMPYSVISDSPRS-WIQVQIPASHPVLTLSPEKALNFEG 301
            P  QI  +  +D G Y C A     ++  +S R   ++V +P   P +   P      E 
Sbjct: 657  PPLQIEKVDLRDEGIYTCAAT----NLAGESKREVALKVLVP---PNIEPGPVNKAVLEN 709

Query: 302  TKVTLHCETQEDSLRTLYRFYHEGVP-------LRHKSVRCERGASISF--------SLT 346
              VTL C                GVP         H+ V    G ++S            
Sbjct: 710  ASVTLEC-------------LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQ 756

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNL-SSPEDLIFEGAKVTLHCEAQR 405
              ++G+Y C A N  G+   +   L V VP   P + L  S    +     V L C A  
Sbjct: 757  LSDAGSYRCVASNVAGSTELR-YGLRVNVP---PRITLPPSLPGPVLVNTPVRLTCNATG 812

Query: 406  GSLPILYQFHH----EGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKA 461
               P L           A          G V    S  A  SG Y C A +  G  R   
Sbjct: 813  APSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 872

Query: 462  VSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPS 521
            V L V +P   P +             +V L C+     P +L  ++ +  PL     P 
Sbjct: 873  V-LQVHMP---PSILGEELNVSVVANESVALECQSHAMPPPVL-SWWKDGRPL--EPRPG 925

Query: 522  VGRVSFSFSLTE------GHSGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRVPR 574
            V  +S   +L +        +G+Y C A N  G  RSE   +L V V    P+  LR   
Sbjct: 926  V-HLSADKALLQVDRADVWDAGHYTCEALNQAG--RSEKHYNLNVWV---APVFPLRESH 979

Query: 575  AQAV-VGDLLELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTAE----H 628
               V  G    L CE  RG P P + W        G  +      A   L    +     
Sbjct: 980  TLTVREGHPTSLSCEC-RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ 1038

Query: 629  SGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQ-AVVGD-LLELHCEALRGS 686
             G Y+CE +N +V   S  + L V VP    I   R P  Q +VV D +  L C A    
Sbjct: 1039 EGTYTCECSN-VVGNSSQDLQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKP 1095

Query: 687  SPILYWFYHEDVTLGKISAP-SGGGASFNLS-LTTEHSGIYSCEADNGLEAQRSEMVTLK 744
             P + W         ++       G S ++      H+G YSC A+N L  +      L 
Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELS 1154

Query: 745  VAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFF--HEDVTLGNRS-SPSG 801
            V VP              AA+   L L CEA+ G P    R+F   E V+ G  +   +G
Sbjct: 1155 VLVPPELIGDLDPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGEEPVSPGEDTYLLAG 1213

Query: 802  GASLNLSLTAEH-SGNYSCEADNGLGAQR 829
            G  L ++ T E  SG YSC A N  G  R
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEAR 1242



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 185/837 (22%), Positives = 291/837 (34%), Gaps = 141/837 (16%)

Query: 79   ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEV 129
            +SG Y C A      S V  D     L +  P         +SV   +SV L C++ A  
Sbjct: 853  DSGRYSCVAV-----SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMP 907

Query: 130  TLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
                + +K+   L           +    +  A + D G Y C    ++        + +
Sbjct: 908  PPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967

Query: 184  QVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTL-GLGWSL 241
             V   F  P+  + +     G+P +L+CE +       VP  +  + +D Q L G G  L
Sbjct: 968  WVAPVF--PLRESHTLTVREGHPTSLSCECR------GVPFPKISWRKDGQPLPGEGAGL 1019

Query: 242  SPNFQITAMWS------KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEK 295
                 +  +           G Y C+ + +   V + S    ++V +P         P +
Sbjct: 1020 QHVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQ 1076

Query: 296  ALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE------- 348
                +    TL C        T+  +  +G P+         GA +   L  +       
Sbjct: 1077 VSVVQDGVATLECNATGKPPPTV-TWERDGQPV---------GAELGLQLQNQGQSLHVE 1126

Query: 349  -----NSGNYYCTADNGLGAKPSKAVSLSVTVPVS-----HPVLNLSSPEDLIFEGAKVT 398
                 ++G Y C A+N L  +  +   LSV VP        P+ N+++        + +T
Sbjct: 1127 RAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPELIGDLDPLTNITAALH-----SPLT 1180

Query: 399  LHCEAQRGSLPILYQFHHEGAALERRSANS-AGGVAISFSLTAEH-SGNYYCTADNGFGP 456
            L CEA     P +  F  E            AGG  +  + T E  SG Y C A N  G 
Sbjct: 1181 LLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE 1240

Query: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516
             R +  S+ V VP S     L     +  +G T  L C V  G PQ    ++ +  PL  
Sbjct: 1241 AR-RNFSVEVLVPPSIENEDLEEVIKV-LDGQTAHLMCNVT-GHPQPKLTWFKDGRPLAR 1297

Query: 517  SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572
                 +        + + +   +G+Y C A N  G +     +S+ +   +         
Sbjct: 1298 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1357

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTA------ 626
                  V + + L CEA     P + W            AP   EAS N+ L        
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWM--------KDGAPF--EASRNIQLLPGTHGLQ 1407

Query: 627  ------EHSGNYSCEANNGLVAQHSDTISLSVIVPVS----RPILTFRAPRAQAVVGDLL 676
                  E +G Y+C   N L  +      + V++P S     P+        +  V   L
Sbjct: 1408 ILNAQKEDAGQYTCVVTNEL-GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTL 1466

Query: 677  ELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLSLT-TEHSGIYSCEADNGLE 734
             L CE+     P + W+   + VT        G G    +  T    SG Y C A N   
Sbjct: 1467 TLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1526

Query: 735  AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG----------SPLILY 784
                +   L    P+ + V      G  +A  ++L    EA  G          +P  LY
Sbjct: 1527 EDDQDFNVLIQVPPMFQKV------GDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580

Query: 785  -----------RFFHEDVTLGNRSSPS---GGASLNLSLT-AEHSGNYSCEADNGLG 826
                        ++ ED  L      S   GG  L + L  AE++G YSC+A N +G
Sbjct: 1581 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1637



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 137/528 (25%), Positives = 193/528 (36%), Gaps = 69/528 (13%)

Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE---GAKVTLHCEA 403
           + ++G Y C A N +GA   KA  L V VP   P +  +     + +   G  V L C A
Sbjct: 374 SSDAGVYTCKASNAVGAA-EKATRLDVYVP---PTIEGAGGRPYVVKAVAGRPVALECVA 429

Query: 404 QRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAE-HSGNYYCTADNGFGPQRSK 460
           +    P L  +HHEG   A    S     G  +      E  SG Y C A +   P    
Sbjct: 430 RGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASS---PAGEA 485

Query: 461 AVSLSVTVPVSHPVLTLSS-AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP---LWS 516
            +  SV V V   +L      +  T  G  + L C+   GSP    Q+     P   L  
Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS-GSPVPTIQWLQNGRPAEELAG 544

Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQ 576
               S G       +   HSG + C A N  G   +EV    V+V        L VP  Q
Sbjct: 545 VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVE---VSVHGEWAPGVLEVPIGQ 601

Query: 577 AVVGDLLELHCEAPRGSPPILY--WFYHEDVTLGSS--------SAPSGGEASFNL---- 622
              G   E H   P    P ++  W  H    L             P+G   +++L    
Sbjct: 602 YHWGX--EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPL 659

Query: 623 ---SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDL-LEL 678
               +     G Y+C A N L  +    ++L V+VP +        P  +AV+ +  + L
Sbjct: 660 QIEKVDLRDEGIYTCAATN-LAGESKREVALKVLVPPNIE----PGPVNKAVLENASVTL 714

Query: 679 HCEALRGSSPILYWFY-HEDVTLGKISAPSGGGASFNLSLTT-EHSGIYSCEADNGLEAQ 736
            C A     P + WF  H+ V+       S  G    +       +G Y C A N +   
Sbjct: 715 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGS 773

Query: 737 RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG-SPLILYRFFHEDVTLGN 795
                 L+V VP  R  L    PG    V   + L C A    SP +++      +  GN
Sbjct: 774 TELRYGLRVNVP-PRITLPPSLPGP-VLVNTPVRLTCNATGAPSPTLMW------LKDGN 825

Query: 796 RSSPSGGASLNL----------SLTAEHSGNYSCEADNGLGAQRSETV 833
             SP+G   L +          S  A  SG YSC A + +G  R + V
Sbjct: 826 PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 113/488 (23%), Positives = 193/488 (39%), Gaps = 39/488 (7%)

Query: 162  GAYRCTGYKESCCPVSSNTVKIQVQ-EPFTRPVLRASSFQPISGNPVTLTCETQLSLERS 220
            G Y C+    +   V+   V + VQ  P  +P+   S  + ++   V L CE    + R 
Sbjct: 2732 GRYTCSA--RNSAGVAHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEAS-GIPRP 2786

Query: 221  DVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWI 278
             +  +      +   G+   + P  Q+    +  +D+G Y C A     S +    ++ +
Sbjct: 2787 TITWQKEGL--NVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMG---KTRL 2841

Query: 279  QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRC 335
             VQ+P   PV+          EG+   L C+ +  S      +  +G P+     K    
Sbjct: 2842 VVQVP---PVIENGLPDLSTTEGSHAFLPCKAR-GSPEPNITWDKDGQPVSGAEGKFTIQ 2897

Query: 336  ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395
              G  +  +L  +++G Y CTA+N +G +  + V L++ V    PV      +  +  G 
Sbjct: 2898 PSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVL---PVFTTLPGDRSLRLGD 2953

Query: 396  KVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG 455
            ++ L C A+    P +    ++    E  S    G      +++ E SG Y C A+N  G
Sbjct: 2954 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 3013

Query: 456  PQRSKAVSLSVTVPVSHPVLTLSSAEALTFE--GATVTLHCEVQRGSPQILYQFYHEDMP 513
              R++AVS    V V    +    A +   E  G ++ L C V RG P     +  + +P
Sbjct: 3014 --RTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLP 3067

Query: 514  LWSSSTP-SVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLR 571
            L  S     +   S +   TE   +G Y C A+N  G  +  V    + V  S P+  + 
Sbjct: 3068 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV----ILVLQSAPVFQVE 3123

Query: 572  VPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL-SLTAEHSG 630
                    GD + L C+A     P + W         S    +  + S  L ++    +G
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3183

Query: 631  NYSCEANN 638
             Y C A+N
Sbjct: 3184 TYDCVAHN 3191



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 151/638 (23%), Positives = 239/638 (37%), Gaps = 97/638 (15%)

Query: 246 QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVT 305
           Q+    S D+G Y CKA+    +V +    + + V +P +       P       G  V 
Sbjct: 368 QLGRAQSSDAGVYTCKASN---AVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVA 424

Query: 306 LHCETQEDSLRTLYRFYHEGVPLRHKS-VRCERGASI--SFSLTTENSGNYYCTADNGLG 362
           L C  +     TL  ++HEG+P+   +  R E   S+    S    +SG Y C A +  G
Sbjct: 425 LECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 483

Query: 363 AKPSKAVSLSVTVPVSHPVL---NLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGA 419
                 +  SV V V   +L    L     ++  G  + L C+A    +P + Q+   G 
Sbjct: 484 ---EAVLQYSVEVQVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTI-QWLQNG- 536

Query: 420 ALERRSANSAGGVAISFSLTA--------EHSGNYYCTADNGFGPQRSKAVSLSVTVPVS 471
               R A    GV ++   T         +HSG + C A N  G   ++ V +SV    +
Sbjct: 537 ----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE-VEVSVHGEWA 591

Query: 472 HPVLTLSSAEAL--TFEGATVTLHCE--VQRG----SPQILYQFYHEDMPLWSSSTPSVG 523
             VL +   +        ++    C+  V RG        L + +     LW   T    
Sbjct: 592 PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPT---- 647

Query: 524 RVSFSFSLTE---------GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPR 574
            +  ++SL              G Y C A N  G  + EV    +  P   P      P 
Sbjct: 648 GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP-----GPV 702

Query: 575 AQAVVGDL-LELHCEAPRGSPPILYWFY-HEDVT--LGSSSAPSGGEASFNLSLTAEHSG 630
            +AV+ +  + L C A    PP + WF  H+ V+  +G + +  G       +  ++ +G
Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSD-AG 761

Query: 631 NYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPIL 690
           +Y C A+N      S  +   + V V   I    +     +V   + L C A    SP L
Sbjct: 762 SYRCVASN---VAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTL 818

Query: 691 YWFYHEDVTLGKISAPSG--------GGASFNL-SLTTEHSGIYSCEADNGLEAQRSEMV 741
            W        G   +P+G        GG    L S     SG YSC A + +   R ++V
Sbjct: 819 MWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873

Query: 742 TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSG 801
            L+V +P   P +            + + L C++    P +L   + +D   G    P  
Sbjct: 874 -LQVHMP---PSILGEELNVSVVANESVALECQSHAMPPPVL--SWWKD---GRPLEPRP 924

Query: 802 GASLNLS--------LTAEHSGNYSCEADNGLGAQRSE 831
           G  L+               +G+Y+CEA N  G  RSE
Sbjct: 925 GVHLSADKALLQVDRADVWDAGHYTCEALNQAG--RSE 960



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 40/314 (12%)

Query: 75   LEVQESGEYRCQAQGSP--LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVT 130
            LE Q++G Y C A+ +       VHL      +    P   S+  GD + LRC A+   T
Sbjct: 2907 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 2966

Query: 131  LNNTIYKNDNVLAFLNKRTD----FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQ 186
                   ND  +       D            +D+G Y C  + E+    +     + V+
Sbjct: 2967 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC--WAENRVGRTQAVSFVHVK 3024

Query: 187  EPFTRPVLRASSF----QPISGNPVTLTCETQ------LSLERSDVPLRFRFFRDDQTLG 236
            E    PVL+  +F    +P+ G+ + L C  +      +   +  +PLR    R     G
Sbjct: 3025 EA---PVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG 3080

Query: 237  LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296
                   +  I      D+G Y C A               + + +  S PV  + P+  
Sbjct: 3081 -------SLTIHRTERDDAGRYQCLAEN------EMGVAKKVVILVLQSAPVFQVEPQDM 3127

Query: 297  LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRCERGASISF-SLTTENSGNYY 354
                G  V L C+   +   T+  +   G PLR  + +R     S+   ++ T ++G Y 
Sbjct: 3128 TVRSGDDVALRCQATGEPTPTI-EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 3186

Query: 355  CTADNGLGAKPSKA 368
            C A N LG+  ++A
Sbjct: 3187 CVAHNLLGSATARA 3200


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  107 bits (266), Expect = 7e-23
 Identities = 197/818 (24%), Positives = 319/818 (38%), Gaps = 121/818 (14%)

Query: 74   ILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSV-----------FEGDSVVLR 122
            +L V+++G Y C A+     SP      S  + +QAP ++                +VL 
Sbjct: 3548 VLRVRDAGLYTCLAE-----SPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE 3602

Query: 123  CRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV 176
            C  +AE     T +++  VL       F  +     +      D+G Y CT    +    
Sbjct: 3603 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA---- 3658

Query: 177  SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL---ERSDVPLRFRFFRDDQ 233
             S +V  +V E  T P +R       SG P       Q +L   +   VP     +R D+
Sbjct: 3659 GSTSVAFRV-EIHTVPTIR-------SGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 3710

Query: 234  T----LGLGWSLSP--NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP 287
                     + + P  + +I  + ++D+G Y C A+    S  SD     ++V  P   P
Sbjct: 3711 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN---SAGSDRQGRDLRVLEP---P 3764

Query: 288  VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGA-----SIS 342
             +  SP        T   L CE    S + L  ++ +G  L     R ++GA     S +
Sbjct: 3765 AIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKL---DFRLQQGAYRLLPSNA 3820

Query: 343  FSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399
              LT    ++S  + C   N +G +  +   ++V VP   P +     +  +   A V L
Sbjct: 3821 LLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVHVP---PTIADDQTDFTVTMMAPVVL 3876

Query: 400  HCEAQRGSLPILYQFHHEGAALERRSA----NSAGGVAISFSLTAEHSGNYYCTADNGFG 455
             C +     P +  +   GA L  R +    + +G + I  +L   H+G Y C+A N  G
Sbjct: 3877 TCHSTGIPAPTV-SWSKAGAQLGARGSGYRVSPSGALEIGQALPI-HAGRYTCSARNSAG 3934

Query: 456  PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515
                         PV  P+ ++  A A       V L CE   G P+    +  E + + 
Sbjct: 3935 VAHKHVFLTVQASPVVKPLPSVVRAVA----EEEVLLPCEAS-GIPRPTITWQKEGLNVA 3989

Query: 516  SSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572
            +  +  V   G++  + +  E  +GNY C A N  G    +   L V VP   P++   +
Sbjct: 3990 TGVSTQVLPGGQLRIAHASPED-AGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGL 4044

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-SGGEASFNL--------- 622
            P      G    L C+A RGSP         ++T      P SG E  F +         
Sbjct: 4045 PDLSTTEGSHAFLPCKA-RGSP-------EPNITWDKDGQPVSGAEGKFTIQPSGELLVK 4096

Query: 623  SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
            +L  + +G Y+C A N  V +    + L+++V    P+ T         +GD L L C A
Sbjct: 4097 NLEGQDAGTYTCTAENA-VGRARRRVHLTILV---LPVFTTLPGDRSLRLGDRLWLRCAA 4152

Query: 683  LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL-EAQRSEMV 741
                +P + W  ++      +S   GG      +++ E SG Y C A+N +   Q    V
Sbjct: 4153 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212

Query: 742  TLKVAVPVSRPVLTLRA-PGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800
             +K A     PVL   A       VG  ++L C  +RG P+    +  + + L  R S  
Sbjct: 4213 HVKEA-----PVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDIHWIKDGLPL--RGSHL 4264

Query: 801  GGASLNLSLT-----AEHSGNYSCEADNGLGAQRSETV 833
                 N SLT      + +G Y C A+N +G  +   +
Sbjct: 4265 RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVI 4302



 Score =  106 bits (264), Expect = 1e-22
 Identities = 207/857 (24%), Positives = 326/857 (38%), Gaps = 83/857 (9%)

Query: 19   RTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY----LGKEILRETPDNI 74
            + P  I  L     T      V+L C      +P+ T WY       LG+E+      + 
Sbjct: 2934 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT-WYKDSQALSLGEEVFLLPGTHT 2992

Query: 75   LEV-----QESGEYRCQAQGSP--------LSSPVHLDFSSASLILQAPLSVFEGDSVVL 121
            L++      +SG Y C+A  +         LS  V   F  A    Q  + V  GD  VL
Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 3052

Query: 122  RCRAKAEVTLNNTIYKNDNVLAFLNKRTD-------FHIPHACLKDNGAYRCTGYKESCC 174
             C   A      T YK+   L  L +RT          I  A + D G Y C     +  
Sbjct: 3053 SCETDALPEPTVTWYKDGQPLV-LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 3111

Query: 175  PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
             V + T+ +QV   F  P  +  +   ++G+P+ LTC+       +   L+ R   +   
Sbjct: 3112 AVRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA 3169

Query: 235  LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294
            +    S     Q++ +    +G Y C A     +  +++ + ++   + A     +    
Sbjct: 3170 VHGVVSRGGRLQLSRLQPAQAGTYTCVAE----NTQAEARKDFVVAVLVAPRIRSSGVAR 3225

Query: 295  KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-----RHKSVRCERGASISFSLTTEN 349
            +    EG +V L CE        +  +  +G PL      H     + G+ +   L   +
Sbjct: 3226 EHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 3284

Query: 350  SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLP 409
            +G Y C A N  G + ++  +++V VP +       S   +   G  VT+ C   RGS P
Sbjct: 3285 AGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPP 3342

Query: 410  ILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466
            I   +  +G  L   +R   + +G       +    +G + C A +  G    +  +L V
Sbjct: 3343 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQV 3401

Query: 467  TV-PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRV 525
             V PV  PV   +  + +   G+ V L CE  RG P  L  +  +  PL S S      +
Sbjct: 3402 QVPPVLEPVEFQN--DVVVVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLEQGPSL 3458

Query: 526  SFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV-GDLLE 584
                ++  G SG Y C A +  G  R       +TV     I     P   ++  G  +E
Sbjct: 3459 QLE-AVGAGDSGTYSCVAVSEAGEARRH---FQLTVMEPPHIEDSGQPTELSLTPGAPME 3514

Query: 585  LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644
            L C+A     P + W  H+D   G +       +     L    +G Y+C     L    
Sbjct: 3515 LLCDAQGTPQPNITW--HKD---GQALTRLENNSRATRVLRVRDAGLYTC-----LAESP 3564

Query: 645  SDTISLSVIVPVSRP--ILTFRAPR-AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701
            +  I  S  V V  P  I+  R PR    +    L L C      +P + W  H D  + 
Sbjct: 3565 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW--HRDGIVL 3622

Query: 702  KISA----PSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757
            +  A    P  G      +L+T  SG YSC A N   A  S  V  +V +  + P +   
Sbjct: 3623 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARN---AAGSTSVAFRVEIH-TVPTIRSG 3678

Query: 758  APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLTAE 812
             P  + +V     L C+A  G P  L  +  + V L  RS      P G   +   + A+
Sbjct: 3679 PPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ-PVLAQ 3736

Query: 813  HSGNYSCEADNGLGAQR 829
             +G+Y C A N  G+ R
Sbjct: 3737 DAGHYLCLASNSAGSDR 3753



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 228/981 (23%), Positives = 344/981 (35%), Gaps = 179/981 (18%)

Query: 16   QFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKEILR--ETP 71
            Q   T  P   +  P  TV  GE   L+C+     +P    W    R L     R  +  
Sbjct: 510  QIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG-EAPYNLTWVRDWRVLPASTGRVAQLA 568

Query: 72   DNILEVQ-----ESGEYRC---QAQGSPLSSPVHLDFSSASLILQAPLSVF-EGDSVVLR 122
            D  LE+      + G Y+C    A G   +S   L   +  + +      F +G  V + 
Sbjct: 569  DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 628

Query: 123  CRAKAEVTLNNTIYKNDNVLA-----FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVS 177
            C A    T + +  +    L       ++ +    I     +D G Y C    E      
Sbjct: 629  CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE--VGTD 686

Query: 178  SNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD--DQTL 235
              TV +   +P +   + A     + G    L CE          P R  ++R   +  L
Sbjct: 687  QETVTLYYTDPPSVSAVNAVVLVAV-GEEAVLVCEAS-----GVPPPRVIWYRGGLEMIL 740

Query: 236  GLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASH-PVLTLSPE 294
                S S   +I A   +D+G Y C+A       +++   +  ++Q+   H P LT  P 
Sbjct: 741  APEGSSSGKLRIPAAQERDAGTYTCRA-------VNELGDASAEIQLAVGHAPQLTELPR 793

Query: 295  KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR--------HKSVRCERGASISFSLT 346
                  G    L C        T+     +G PL          +S + + G     S+ 
Sbjct: 794  DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853

Query: 347  TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406
             E+   Y C A N  G   ++A    +    + P +  S+P   + EG  V+L C    G
Sbjct: 854  PEDQAPYVCEARNVFGKVQAEA--RLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAG 911

Query: 407  SLPILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVS 463
                   +  +G  L    R S  + G + +  +L  EH+G Y C A N  G Q  + V 
Sbjct: 912  RPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQ-EHAGRYSCVATNTAGSQH-RDVE 969

Query: 464  LSVTVPVS-HPVLTLSSAEALTFEGATVTL--------------------------HCEV 496
            L V VP   HP  T      +T EG   +L                          H  V
Sbjct: 970  LVVQVPPRIHPTAT----HHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV 1025

Query: 497  QRGSPQILYQFYHEDMPLWSSSTP------------SVGRVSFSFSLTE----------- 533
             +    ++ Q   +D   +  +              SV R++ S  + E           
Sbjct: 1026 SKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLR 1085

Query: 534  ------GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRA-QAVVGDLLELH 586
                  G SG+Y CTA N  G      V      P  +P      PR  + +VG+ L+L+
Sbjct: 1086 LAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQP-----GPRVLKVLVGEALDLN 1140

Query: 587  CEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSD 646
            C A     P L W   +D  +     P G  +    ++    +G Y CEA+N      + 
Sbjct: 1141 CVAEGNPEPQLSW--SKDGVVLQGRGPQG--SVHFAAIRTSDAGRYRCEASNS-AGVDAW 1195

Query: 647  TISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAP 706
             + L V+ P         +   + V G+   L C A     P + W        G  S P
Sbjct: 1196 EVELRVLEPPHWG-ADETSGLLERVAGENASLPCPARGTPKPQVTW------RKGPSSEP 1248

Query: 707  SGG---------GASFNLSLTTEHSGIYSCEADN--GLEAQRSEMVTLKVAVPVSRPVLT 755
              G         G+ F  S++   SG Y C+A N  G  ++R+++V   V VP S     
Sbjct: 1249 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLV---VYVPPS----- 1300

Query: 756  LRAPGTHAAV----GDLLELHCEA---------------LRGSPL--ILYRFFHEDVTLG 794
            +R  G  A V    G  L L C+A               L G PL    Y +      +G
Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360

Query: 795  NRSSPSGGASLNLSLTAE-HSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVA 853
                   G SL+     E  SG YSC A+N  G  + +   L +T        P +   A
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT--------PPSVLGA 1412

Query: 854  GGLLSIAGLAAGALLLYCWLS 874
            G    + GLA   + L CW S
Sbjct: 1413 GAAQEVLGLAGADVELQCWTS 1433



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 213/899 (23%), Positives = 324/899 (36%), Gaps = 141/899 (15%)

Query: 34   VFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRE-----TPDNIL------EVQESGE 82
            V  G+   L C       P+ T W+    G+ + R      +PD +L       +  +G 
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLT-WFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGH 2513

Query: 83   YRCQAQGSPLSSPVHLDFSSASLILQAP-------------LSVFEGDSVVLRCRAKAEV 129
            Y C A  +      H   S    +L AP             ++V   + + L C A A  
Sbjct: 2514 YSCIAANAVGEKTKHFQLS----VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 2569

Query: 130  TLNNTIYKN------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
            + N T  K+         +  L       I +A  +D G Y C    E    V +  V++
Sbjct: 2570 SPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 2629

Query: 184  QVQEPFTRP----VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ------ 233
             +    ++      +     +    + +TL CE+      +  P   R+++D Q      
Sbjct: 2630 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW-----AVPPPTIRWYKDGQPVTPSS 2684

Query: 234  ---TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQV-QIP 283
                LG G  L    QI      DSG Y C A  +       ++V+   P  + +V    
Sbjct: 2685 RLQVLGEGRLL----QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 2740

Query: 284  ASHPVLTLSPEKALNF-------EGTKVTLHCETQEDSLRTLYRFYHEGVPLR---HKSV 333
            A+  +L+   E            E     L+C+T       L  +Y E  PL      SV
Sbjct: 2741 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSV 2799

Query: 334  RCERGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392
              + G  +   L   EN+G Y C A N +G        L +T PV      L   E+L+ 
Sbjct: 2800 -LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-----LGDTEELVE 2853

Query: 393  E-----GAKVTLHCEAQRGSLPILYQFHH--EGAALERRSANSAGGVAISFSLTAEHSGN 445
            E      + V+L C A    +P +    +    +   R      G V    +     + +
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 2913

Query: 446  YYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSPQIL 504
            Y C A+N  G    K  +L V VP     L L    A+    ++V+L C+V    +P++ 
Sbjct: 2914 YMCVAENQAG-SAEKLFTLRVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 2970

Query: 505  Y-------QFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSL 557
            +           E   L  + T  +GR   S       SG Y C A N  G +  ++V L
Sbjct: 2971 WYKDSQALSLGEEVFLLPGTHTLQLGRARLS------DSGMYTCEALNAAG-RDQKLVQL 3023

Query: 558  FVTVPVSRPILTLRVPRA--QAV---VGDLLELHCEAPRGSPPILYWFYHED--VTLGSS 610
             V VP +      + PR    AV   VGD   L CE      P + W+      V    +
Sbjct: 3024 SVLVPPA----FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 3079

Query: 611  SAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQA 670
             A  GG+            G YSC+ +N +  +   T +L+V VP      TF  P+ + 
Sbjct: 3080 QALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTVQVPP-----TFENPKTET 3133

Query: 671  ---VVGDLLELHCEALRGSSPILYWFYHE-DVTLGKISAPSGGGASFNLS-LTTEHSGIY 725
               V G  L L C+     +P + W      V    +      G    LS L    +G Y
Sbjct: 3134 VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTY 3193

Query: 726  SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785
            +C A+N     R + V   +  P  R     R    H   G  + L CEA  G P     
Sbjct: 3194 TCVAENTQAEARKDFVVAVLVAPRIRSSGVARE--HHVLEGQEVRLDCEA-DGQPPPDVA 3250

Query: 786  FFHEDVTLGNRSSP------SGGASLNLSLTAEHSGNYSCEADNGLGAQ-RSETVTLYI 837
            +  +   LG    P       GG+ +   L A  +G Y+C A N  G   R  TV + +
Sbjct: 3251 WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 3309



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 203/898 (22%), Positives = 328/898 (36%), Gaps = 136/898 (15%)

Query: 40   VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNIL------------EVQESGEYRCQA 87
            +TL C+      P   +W+    G+E +    D  L            + Q+SG Y C A
Sbjct: 2370 LTLLCEAMGI-PPPAIRWFR---GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 2425

Query: 88   QGSPLSSPVHLDFSSASLI--------LQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKND 139
                 +     +FS   L+        L+  + V +G +  L C          T +K+ 
Sbjct: 2426 SNE--AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 2483

Query: 140  NVLAFLNKRTDFH----------IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPF 189
              LA    R D H          +  A L   G Y C         V   T   Q+    
Sbjct: 2484 RPLA----RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLL 2535

Query: 190  TRPVLRA---SSFQPIS---GNPVTLTCET------QLSLERSDVPLRFRFFRDDQTLGL 237
               +L     S+ + ++    NP++L CE        ++  +   P  F   R+ Q L  
Sbjct: 2536 APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPG 2593

Query: 238  GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPAS----HPVLTLS 292
               L    QI     +D+G Y C       + + ++ +++ ++V IP S     P+  + 
Sbjct: 2594 THGL----QILNAQKEDAGQYTCVVT----NELGEAVKNYHVEVLIPPSISKDDPLGEVG 2645

Query: 293  PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLT---TEN 349
             ++      + +TL CE+      T+ R+Y +G P+   S     G      +      +
Sbjct: 2646 VKEVKTKVNSTLTLECESWAVPPPTI-RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSD 2704

Query: 350  SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------------IFE 393
            SG Y C A N  G        L    P+   V + S+  ++                I E
Sbjct: 2705 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 2764

Query: 394  GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAEHSGNYYCTAD 451
                 L+C+      P L  +  +   +A +  S    G V     + AE++G Y C A 
Sbjct: 2765 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 2824

Query: 452  NGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFE-----GATVTLHCEVQRGSPQILYQ 506
            N  G        L +T PV      L   E L  E      +TV+L C    G+P     
Sbjct: 2825 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTIS 2878

Query: 507  FYHEDMPLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPV 563
            +    +P   S    V   G+V    +     + +Y C A+N  G    ++ +L V VP 
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG-SAEKLFTLRVQVPP 2937

Query: 564  SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHED-VTLGSSSAPSGGEASFNL 622
               I  L + +  A++   + L C+      P + W+     ++LG       G  +  L
Sbjct: 2938 R--IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 2995

Query: 623  SLTA-EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR-APRA--QAV---VGDL 675
                   SG Y+CEA N    +    + LSV+VP +     FR APR    AV   VGD 
Sbjct: 2996 GRARLSDSGMYTCEALNA-AGRDQKLVQLSVLVPPA-----FRQAPRGPQDAVLVRVGDK 3049

Query: 676  LELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLS-LTTEHSGIYSCEADNGL 733
              L CE      P + W+   + + L + +    GG    +        G+YSC+  N  
Sbjct: 3050 AVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVA 3109

Query: 734  -EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
             EA R+  +T++V      P    +        G  L L C+ + G P     +  + + 
Sbjct: 3110 GEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCD-VSGVPAPTVTWLKDRMP 3164

Query: 793  LGNRSSP---SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSG 846
            + + +     S G  L LS L    +G Y+C A+N     R + V   +       SG
Sbjct: 3165 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG 3222



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 127/498 (25%), Positives = 185/498 (37%), Gaps = 39/498 (7%)

Query: 351 GNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPI 410
           G Y CTA +  G   +KA  + VT P   P   + +P   +  G    L C    G  P 
Sbjct: 492 GTYECTAVSRAGTGRAKA-QIVVTDP---PPQLVPAPNVTVSPGETAVLSCRVL-GEAPY 546

Query: 411 LYQFHHEGAALERRSANSAGGVAISFSLTA---EHSGNYYCTADNGFGPQRSKAVSLSVT 467
              +  +   L   +   A    +S  ++       G Y C A N  G  R+     SV 
Sbjct: 547 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-----SVW 601

Query: 468 VPVSH-PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVS 526
           + V   P +++ ++     +G  V + C    G P     +  E   L   S   V    
Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSAS-GYPTPHISWSRESQALQEDSRIHVDAQG 660

Query: 527 FSF--SLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLE 584
                 +    +GNY C A N  G  + E V+L+ T P S   +   V  A   VG+   
Sbjct: 661 TLIIQGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYTDPPSVSAVNAVVLVA---VGEEAV 716

Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644
           L CEA    PP + W+      + +    S G+     +   + +G Y+C A N L    
Sbjct: 717 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD-AGTYTCRAVNEL-GDA 774

Query: 645 SDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG-KI 703
           S  I L+V      P LT         +G    L C A     P + W   +   LG ++
Sbjct: 775 SAEIQLAV---GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 831

Query: 704 SAPSGG-------GASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTL 756
            A  G        G  F  S+  E    Y CEA N     ++E     +    + P +  
Sbjct: 832 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAE--ARLIVTGHAPPQIAS 889

Query: 757 RAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL--GNRSSPSGGASLNLSLTA-EH 813
            AP      G  + L C  L G PL    +  +   L  G+R S     SL+L     EH
Sbjct: 890 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEH 949

Query: 814 SGNYSCEADNGLGAQRSE 831
           +G YSC A N  G+Q  +
Sbjct: 950 AGRYSCVATNTAGSQHRD 967



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 220/899 (24%), Positives = 319/899 (35%), Gaps = 157/899 (17%)

Query: 37   GERVTLTCKGFRFYSPQKTKW--------YHRYLGKEILRETPDNILEVQ--ESGEYRCQ 86
            GE  +L C       PQ T W         H   G  +L E    +  V   +SG+Y CQ
Sbjct: 1221 GENASLPCPARGTPKPQVT-WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279

Query: 87   AQGSPLSSPVHLDFSSASLILQAPLSVFE-----------GDSVVLRCRAKAEVTLNNTI 135
            A     ++ V      A L++  P S+ E           G S+ L C A     +   +
Sbjct: 1280 A-----TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANG-FPVPEIV 1333

Query: 136  YKNDNVLA----------------------FLNKRTDFHIPHACLKDNGAYRCTGYKESC 173
            +  D  L                        L++    H P     D+G Y C    E+ 
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA--ENQ 1391

Query: 174  CPVSSNTVKIQVQEPFTRPVLRASSFQPI---SGNPVTLTCETQLSLERSDVPL-RFRFF 229
               +     + V  P +  VL A + Q +   +G  V L C T      S VP  +  + 
Sbjct: 1392 AGTAQRDFHLLVLTPPS--VLGAGAAQEVLGLAGADVELQCWT------SGVPTPQVEWT 1443

Query: 230  RDDQTLGLGWSLSPNFQ---------ITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQV 280
            +D Q +  G    P+ Q         IT     D G Y C A    +S      R + Q+
Sbjct: 1444 KDRQPVLPG---GPHLQVQEDGQVLRITGSHVGDEGRYQCVA----FSPAGQQARDF-QL 1495

Query: 281  QIPASHPVLTLSPE--KALNFEGTKVTLHCETQEDSLRTLYRFYHEG--VPLRHKSVRCE 336
            ++ A  P +  S E  +    E   V L CE +      +  ++ +G  +P   K V   
Sbjct: 1496 RVHAP-PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI-TWFKDGALLPTSTKVVYTR 1553

Query: 337  RGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE-- 393
             G  +      + ++G Y C A N +GA   KA  L V VP   P +  +     + +  
Sbjct: 1554 GGRQLQLGRAQSSDAGVYTCKASNAVGAA-EKATRLDVYVP---PTIEGAGGRPYVVKAV 1609

Query: 394  -GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAE-HSGNYYCT 449
             G  V L C A+    P L  +HHEG   A    S     G  +      E  SG Y C 
Sbjct: 1610 AGRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV 1668

Query: 450  ADNGFGPQRSKAVSLSVTVPVSHPVLTLSS-AEALTFEGATVTLHCEVQRGSPQILYQFY 508
            A +   P     +  SV V V   +L      +  T  G  + L C+   GSP    Q+ 
Sbjct: 1669 ASS---PAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS-GSPVPTIQWL 1724

Query: 509  HEDMP---LWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565
                P   L      S G       +   HSG + C A N  G   +EV    V+V    
Sbjct: 1725 QNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVE---VSVHGEW 1781

Query: 566  PILTLRVPRAQAVVGDLLELHCEAPRGSPPILY--WFYHEDVTLGSS--------SAPSG 615
                L VP  Q   G   E H   P    P ++  W  H    L             P+G
Sbjct: 1782 APGVLEVPIGQYHWGX--EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG 1839

Query: 616  GEASFNL-------SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRA 668
               +++L        +     G Y+C A N L  +    ++L V+VP +        P  
Sbjct: 1840 IPVAYSLPPPLQIEKVDLRDEGIYTCAATN-LAGESKREVALKVLVPPNIE----PGPVN 1894

Query: 669  QAVVGDL-LELHCEALRGSSPILYWFY-HEDVTLGKISAPSGGGASFNLSLTT-EHSGIY 725
            +AV+ +  + L C A     P + WF  H+ V+       S  G    +       +G Y
Sbjct: 1895 KAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSY 1954

Query: 726  SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG-SPLILY 784
             C A N +         L+V VP  R  L    PG    V   + L C A    SP +++
Sbjct: 1955 RCVASN-VAGSTELRYGLRVNVP-PRITLPPSLPGP-VLVNTPVRLTCNATGAPSPTLMW 2011

Query: 785  RFFHEDVTLGNRSSPSGGASLNL----------SLTAEHSGNYSCEADNGLGAQRSETV 833
                  +  GN  SP+G   L +          S  A  SG YSC A + +G  R + V
Sbjct: 2012 ------LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 2064



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 150/652 (23%), Positives = 241/652 (36%), Gaps = 62/652 (9%)

Query: 206  PVTLTCETQLSLERSDVPLRFRFFRDDQTLG----LGWSLSPNFQITAMWSKDSGFYWCK 261
            P+ ++C    +L     P R +  R +  LG       S + +++I      + G Y C 
Sbjct: 443  PLLVSCSVHSAL-----PFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECT 497

Query: 262  AATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRF 321
            A +      + + R+  Q+ +    P L  +P   ++  G    L C    ++   L  +
Sbjct: 498  AVSR-----AGTGRAKAQIVVTDPPPQLVPAPNVTVS-PGETAVLSCRVLGEAPYNL-TW 550

Query: 322  YHEGVPLRHKSVRCERGASISFSLT---TENSGNYYCTADNGLGAKPSKAVSLSVTVPVS 378
              +   L   + R  + A +S  ++     + G Y C A N  G   +     SV + V 
Sbjct: 551  VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-----SVWLLVR 605

Query: 379  H-PVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSAN--SAGGVAIS 435
              P +++ +      +G +V + C A     P +  +  E  AL+  S     A G  I 
Sbjct: 606  EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI-SWSRESQALQEDSRIHVDAQGTLII 664

Query: 436  FSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCE 495
              +  E +GNY C A N  G  + + V+L  T P   P ++  +A  L   G    L CE
Sbjct: 665  QGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYTDP---PSVSAVNAVVLVAVGEEAVLVCE 720

Query: 496  VQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVV 555
                 P  +  +      + +    S G++    +  E  +G Y C A N  G   +E+ 
Sbjct: 721  ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP-AAQERDAGTYTCRAVNELGDASAEI- 778

Query: 556  SLFVTVPVSRPILTLRVPRAQAV-VGDLLELHCEAPRGSPPILYWFYHEDVTLG------ 608
                 + V        +PR   V +G    L C A    PP + W   +   LG      
Sbjct: 779  ----QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAG 834

Query: 609  ---SSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRA 665
                S  P  G   F  S+  E    Y CEA N      ++  +  ++   + P +   A
Sbjct: 835  RGSRSRQPDSGVLFFE-SVAPEDQAPYVCEARNVFGKVQAE--ARLIVTGHAPPQIASSA 891

Query: 666  PRAQAVVGDLLELHCEALRGSS-PILYWFYH-EDVTLGKISAPSGGGASFNLSLTTEHSG 723
            P  + + G  + L C  L G   P  +W      +  G   +    G+        EH+G
Sbjct: 892  PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 951

Query: 724  IYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLIL 783
             YSC A N   +Q  + V L V VP   P +   A       G    L C A  G P   
Sbjct: 952  RYSCVATNTAGSQHRD-VELVVQVP---PRIHPTATHHITNEGVPASLPCVA-SGVPAPT 1006

Query: 784  YRFFHEDVTLGNR----SSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSE 831
              +  E   L +R    +    G  L    +A+ +G Y C A N +G    E
Sbjct: 1007 ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE 1058



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 102/392 (26%), Positives = 160/392 (40%), Gaps = 27/392 (6%)

Query: 348  ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
            E++GNY C A N  G+   K   L V VP   PV+    P+    EG+   L C+A RGS
Sbjct: 4010 EDAGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGLPDLSTTEGSHAFLPCKA-RGS 4064

Query: 408  LPILYQFHHEG---AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464
                  +  +G   +  E +      G  +  +L  + +G Y CTA+N  G  R + V L
Sbjct: 4065 PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR-VHL 4123

Query: 465  SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGR 524
            ++ V    PV T    +     G  + L C   RGSP     +   D P+    +   G 
Sbjct: 4124 TILVL---PVFTTLPGDRSLRLGDRLWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDGG 4179

Query: 525  VSFS-FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583
             +    +++   SG Y C A+N  G  R++ VS FV V  +  +           VG  +
Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVG--RTQAVS-FVHVKEAPVLQGEAFSYLVEPVGGSI 4236

Query: 584  ELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGL- 640
            +L C   RG P P ++W        GS         S  +  T  + +G Y C A N + 
Sbjct: 4237 QLDCVV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMG 4295

Query: 641  VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFY-HEDVT 699
            VA+      + ++V  S P+            GD + L C+A    +P + W    + + 
Sbjct: 4296 VAK-----KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR 4350

Query: 700  LGKISAPSGGGASFNLSLTTEHSGIYSCEADN 731
              +       G+ +  ++ T  +G Y C A N
Sbjct: 4351 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 4382



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 134/520 (25%), Positives = 188/520 (36%), Gaps = 84/520 (16%)

Query: 349  NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL 408
            + G Y C A N L  +  + V+L V VP   P +        + E A VTL C A     
Sbjct: 1859 DEGIYTCAATN-LAGESKREVALKVLVP---PNIEPGPVNKAVLENASVTLECLASGVPP 1914

Query: 409  PILYQF--HHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466
            P +  F  H   ++    + +  G V          +G+Y C A N  G    +   L V
Sbjct: 1915 PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRV 1973

Query: 467  TVPVSHPVLTLS-SAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV--- 522
             VP   P +TL  S          V L C    G+P     +  +  P+  + TP +   
Sbjct: 1974 NVP---PRITLPPSLPGPVLVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVF 2029

Query: 523  --GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVG 580
              GRV    S     SG Y C A +  G  R +VV L V +P   P +         V  
Sbjct: 2030 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMP---PSILGEELNVSVVAN 2085

Query: 581  DLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHS----------- 629
            + + L C++    PP+L W+       G    P  G     + L+A+ +           
Sbjct: 2086 ESVALECQSHAMPPPVLSWWKD-----GRPLEPRPG-----VHLSADKALLQVDRADVWD 2135

Query: 630  -GNYSCEANNGLVAQHSDT-ISLSVIVPVSRPILTFRAPRAQAV-VGDLLELHCEALRGS 686
             G+Y+CEA N   A HS+   +L+V V    P+   R      V  G    L CE     
Sbjct: 2136 AGHYTCEALNQ--AGHSEKHYNLNVWVA---PVFPLRESHTLTVREGHPTSLSCECRGVP 2190

Query: 687  SPILYW------FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740
             P + W         E   L  +SA   G   +         G Y+CE  N +    S+ 
Sbjct: 2191 FPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSN-VVGNSSQD 2247

Query: 741  VTLKVAVPVSRPVLTLRAPGTHAAV--GDLLELHCEALRGSPLILYRFFHEDVTLGNRSS 798
            + L+V VP    +   R P T  +V    +  L C A    P               R  
Sbjct: 2248 LQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPP---------PTVTWERDG 2296

Query: 799  PSGGASLNLSLT------------AEHSGNYSCEADNGLG 826
               GA L L L             A H+G YSC A+N  G
Sbjct: 2297 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 2336



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 185/837 (22%), Positives = 291/837 (34%), Gaps = 141/837 (16%)

Query: 79   ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEV 129
            +SG Y C A      S V  D     L +  P         +SV   +SV L C++ A  
Sbjct: 2044 DSGRYSCVAV-----SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMP 2098

Query: 130  TLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
                + +K+   L           +    +  A + D G Y C    ++        + +
Sbjct: 2099 PPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158

Query: 184  QVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTL-GLGWSL 241
             V   F  P+  + +     G+P +L+CE +       VP  +  + +D Q L G G  L
Sbjct: 2159 WVAPVF--PLRESHTLTVREGHPTSLSCECR------GVPFPKISWRKDGQPLPGEGAGL 2210

Query: 242  SPNFQITAMWS------KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEK 295
                 +  +           G Y C+ + +   V + S    ++V +P         P +
Sbjct: 2211 QHVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQ 2267

Query: 296  ALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE------- 348
                +    TL C        T+  +  +G P+         GA +   L  +       
Sbjct: 2268 VSVVQDGVATLECNATGKPPPTV-TWERDGQPV---------GAELGLQLQNQGQSLHVE 2317

Query: 349  -----NSGNYYCTADNGLGAKPSKAVSLSVTVPVS-----HPVLNLSSPEDLIFEGAKVT 398
                 ++G Y C A+N L  +  +   LSV VP        P+ N+++        + +T
Sbjct: 2318 RAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPELIGDLDPLTNITAALH-----SPLT 2371

Query: 399  LHCEAQRGSLPILYQFHHEGAALERRSANS-AGGVAISFSLTAEH-SGNYYCTADNGFGP 456
            L CEA     P +  F  E            AGG  +  + T E  SG Y C A N  G 
Sbjct: 2372 LLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE 2431

Query: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516
             R +  S+ V VP S     L     +  +G T  L C V  G PQ    ++ +  PL  
Sbjct: 2432 AR-RNFSVEVLVPPSIENEDLEEVIKV-LDGQTAHLMCNVT-GHPQPKLTWFKDGRPLAR 2488

Query: 517  SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572
                 +        + + +   +G+Y C A N  G +     +S+ +   +         
Sbjct: 2489 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 2548

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTA------ 626
                  V + + L CEA     P + W            AP   EAS N+ L        
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWM--------KDGAPF--EASRNIQLLPGTHGLQ 2598

Query: 627  ------EHSGNYSCEANNGLVAQHSDTISLSVIVPVS----RPILTFRAPRAQAVVGDLL 676
                  E +G Y+C   N L  +      + V++P S     P+        +  V   L
Sbjct: 2599 ILNAQKEDAGQYTCVVTNEL-GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTL 2657

Query: 677  ELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLSLT-TEHSGIYSCEADNGLE 734
             L CE+     P + W+   + VT        G G    +  T    SG Y C A N   
Sbjct: 2658 TLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 2717

Query: 735  AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG----------SPLILY 784
                +   L    P+ + V      G  +A  ++L    EA  G          +P  LY
Sbjct: 2718 EDDQDFNVLIQVPPMFQKV------GDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 2771

Query: 785  -----------RFFHEDVTLGNRSSPS---GGASLNLSLT-AEHSGNYSCEADNGLG 826
                        ++ ED  L      S   GG  L + L  AE++G YSC+A N +G
Sbjct: 2772 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 2828



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 159/613 (25%), Positives = 230/613 (37%), Gaps = 71/613 (11%)

Query: 254  DSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQED 313
            DSG Y C A+    S    S R  + VQ+P   P +   P       G  + L+C   E 
Sbjct: 1093 DSGHYECTASNPAGSA---SHRYVLGVQVP---PQVQPGPRVLKVLVGEALDLNC-VAEG 1145

Query: 314  SLRTLYRFYHEGVPLRHKSVRCERGASISFS-LTTENSGNYYCTADNGLGAKPSKAVSLS 372
            +      +  +GV L+ +  +     S+ F+ + T ++G Y C A N  G   +  V L 
Sbjct: 1146 NPEPQLSWSKDGVVLQGRGPQ----GSVHFAAIRTSDAGRYRCEASNSAGV-DAWEVELR 1200

Query: 373  VTVPVSHPVLNLSSPEDLI--FEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAG 430
            V  P   P         L+    G   +L C A RG+ P       +G + E    +   
Sbjct: 1201 VLEP---PHWGADETSGLLERVAGENASLPCPA-RGT-PKPQVTWRKGPSSE--PLHGQP 1253

Query: 431  GVAI-------SFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEAL 483
            GVA+         S++   SG+Y C A N  G   S+   L V VP S        A   
Sbjct: 1254 GVAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIRE-DGRKANVS 1311

Query: 484  TFEGATVTLHCEVQR-GSPQILY--QFYHEDMPL------WSSSTPSVG-------RVSF 527
               G ++TL C+      P+I++        +PL      W      VG         S 
Sbjct: 1312 GMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL 1371

Query: 528  SF-SLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDL---L 583
             F  + EG SG Y C A+N  G  + +   L +T P       L    AQ V+G     +
Sbjct: 1372 HFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP-----SVLGAGAAQEVLGLAGADV 1426

Query: 584  ELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEH---SGNYSCEANNGL 640
            EL C       P + W       L         E    L +T  H    G Y C A +  
Sbjct: 1427 ELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP- 1485

Query: 641  VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD-LLELHCEALRGSSPILYWFYHEDV- 698
              Q +    L V  P +  I         AV+ D L++L CEA    +P + WF    + 
Sbjct: 1486 AGQQARDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 1543

Query: 699  -TLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757
             T  K+    GG         +  +G+Y+C+A N + A   +   L V VP +      R
Sbjct: 1544 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGR 1602

Query: 758  APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS---PSGGASLNLSLTAE-H 813
                 A  G  + L C A RG P     + HE + +   +     + G+ L L    E  
Sbjct: 1603 PYVVKAVAGRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEAS 1661

Query: 814  SGNYSCEADNGLG 826
            SG YSC A +  G
Sbjct: 1662 SGLYSCVASSPAG 1674



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 113/488 (23%), Positives = 193/488 (39%), Gaps = 39/488 (7%)

Query: 162  GAYRCTGYKESCCPVSSNTVKIQVQ-EPFTRPVLRASSFQPISGNPVTLTCETQLSLERS 220
            G Y C+    +   V+   V + VQ  P  +P+   S  + ++   V L CE    + R 
Sbjct: 3923 GRYTCSA--RNSAGVAHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEAS-GIPRP 3977

Query: 221  DVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWI 278
             +  +      +   G+   + P  Q+    +  +D+G Y C A     S +    ++ +
Sbjct: 3978 TITWQKEGL--NVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMG---KTRL 4032

Query: 279  QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRC 335
             VQ+P   PV+          EG+   L C+ +  S      +  +G P+     K    
Sbjct: 4033 VVQVP---PVIENGLPDLSTTEGSHAFLPCKAR-GSPEPNITWDKDGQPVSGAEGKFTIQ 4088

Query: 336  ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395
              G  +  +L  +++G Y CTA+N +G +  + V L++ V    PV      +  +  G 
Sbjct: 4089 PSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVL---PVFTTLPGDRSLRLGD 4144

Query: 396  KVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG 455
            ++ L C A+    P +    ++    E  S    G      +++ E SG Y C A+N  G
Sbjct: 4145 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 4204

Query: 456  PQRSKAVSLSVTVPVSHPVLTLSSAEALTFE--GATVTLHCEVQRGSPQILYQFYHEDMP 513
              R++AVS    V V    +    A +   E  G ++ L C V RG P     +  + +P
Sbjct: 4205 --RTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLP 4258

Query: 514  LWSSSTP-SVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLR 571
            L  S     +   S +   TE   +G Y C A+N  G  +  V    + V  S P+  + 
Sbjct: 4259 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV----ILVLQSAPVFQVE 4314

Query: 572  VPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL-SLTAEHSG 630
                    GD + L C+A     P + W         S    +  + S  L ++    +G
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 4374

Query: 631  NYSCEANN 638
             Y C A+N
Sbjct: 4375 TYDCVAHN 4382



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 142/559 (25%), Positives = 211/559 (37%), Gaps = 71/559 (12%)

Query: 349  NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL 408
            +SG+Y CTA N  G+   + V L V VP   P +        +  G  + L+C A+    
Sbjct: 1093 DSGHYECTASNPAGSASHRYV-LGVQVP---PQVQPGPRVLKVLVGEALDLNCVAEGNPE 1148

Query: 409  PILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV 468
            P L  +  +G  L+ R    +   A   ++    +G Y C A N  G   +  V L V  
Sbjct: 1149 PQL-SWSKDGVVLQGRGPQGSVHFA---AIRTSDAGRYRCEASNSAGVD-AWEVELRVLE 1203

Query: 469  PVSHPVLTLSSAEALTFEGATVTLHCEVQRGS--PQILYQFYHEDMPLWSSSTPSVGRVS 526
            P  H     +S       G   +L C   RG+  PQ+ ++      PL     P V  + 
Sbjct: 1204 P-PHWGADETSGLLERVAGENASLPCPA-RGTPKPQVTWRKGPSSEPL--HGQPGVAVLE 1259

Query: 527  ----FSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDL 582
                F  S++   SG+Y C A N  G   S    L V VP S      R      + G  
Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIR-EDGRKANVSGMAGQS 1317

Query: 583  LELHCEAPRGSPPILYWF--------------YHEDV---TLGSSSAPSGGEASFNLSLT 625
            L L C+A     P + W               Y  D+    +G       G++     + 
Sbjct: 1318 LTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 1377

Query: 626  AEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDL---LELHCEA 682
               SG YSC A N       D   L V+ P S       A  AQ V+G     +EL C  
Sbjct: 1378 EGDSGLYSCRAENQAGTAQRD-FHLLVLTPPS----VLGAGAAQEVLGLAGADVELQCWT 1432

Query: 683  LRGSSPILYWFYHEDVTLGKISAPSGGGASFN-----LSLTTEH---SGIYSCEADNGLE 734
                +P + W       L     P G           L +T  H    G Y C A +   
Sbjct: 1433 SGVPTPQVEWTKDRQPVL-----PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP-A 1486

Query: 735  AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGD-LLELHCEALRGSPLILYRFFHEDVTL 793
             Q++    L+V  P +  +      G  A + D L++L CEA RG P     +F +   L
Sbjct: 1487 GQQARDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEA-RGVPTPNITWFKDGALL 1543

Query: 794  GNRSS---PSGGASLNLS-LTAEHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSG-P 847
               +      GG  L L    +  +G Y+C+A N +G A+++  + +Y+        G P
Sbjct: 1544 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRP 1603

Query: 848  FAT-GVAGGLLSIAGLAAG 865
            +    VAG  +++  +A G
Sbjct: 1604 YVVKAVAGRPVALECVARG 1622



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 60/235 (25%), Positives = 89/235 (37%), Gaps = 25/235 (10%)

Query: 614 SGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVG 673
           SG  +   L  +    G Y C A    V++     + + IV    P     AP      G
Sbjct: 476 SGNSSWEILRASKAEEGTYECTA----VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPG 531

Query: 674 DLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGI-------YS 726
           +   L C  L  +   L W     V   ++   S G  +    L+ E SGI       Y 
Sbjct: 532 ETAVLSCRVLGEAPYNLTW-----VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 586

Query: 727 CEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRF 786
           C A N     R+ +  L    P     +++     H + G  +++ C A  G P     +
Sbjct: 587 CVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISW 641

Query: 787 FHEDVTLGNRSS---PSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYIT 838
             E   L   S     + G  +   +  E +GNYSC+A N +G  + ETVTLY T
Sbjct: 642 SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYT 695



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 40/314 (12%)

Query: 75   LEVQESGEYRCQAQGSP--LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVT 130
            LE Q++G Y C A+ +       VHL      +    P   S+  GD + LRC A+   T
Sbjct: 4098 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 4157

Query: 131  LNNTIYKNDNVLAFLNKRTD----FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQ 186
                   ND  +       D            +D+G Y C  + E+    +     + V+
Sbjct: 4158 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC--WAENRVGRTQAVSFVHVK 4215

Query: 187  EPFTRPVLRASSF----QPISGNPVTLTCETQ------LSLERSDVPLRFRFFRDDQTLG 236
            E    PVL+  +F    +P+ G+ + L C  +      +   +  +PLR    R     G
Sbjct: 4216 EA---PVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG 4271

Query: 237  LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296
                   +  I      D+G Y C A               + + +  S PV  + P+  
Sbjct: 4272 -------SLTIHRTERDDAGRYQCLAEN------EMGVAKKVVILVLQSAPVFQVEPQDM 4318

Query: 297  LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRCERGASISF-SLTTENSGNYY 354
                G  V L C+   +   T+  +   G PLR  + +R     S+   ++ T ++G Y 
Sbjct: 4319 TVRSGDDVALRCQATGEPTPTI-EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 4377

Query: 355  CTADNGLGAKPSKA 368
            C A N LG+  ++A
Sbjct: 4378 CVAHNLLGSATARA 4391


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  107 bits (266), Expect = 7e-23
 Identities = 197/818 (24%), Positives = 319/818 (38%), Gaps = 121/818 (14%)

Query: 74   ILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSV-----------FEGDSVVLR 122
            +L V+++G Y C A+     SP      S  + +QAP ++                +VL 
Sbjct: 2266 VLRVRDAGLYTCLAE-----SPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE 2320

Query: 123  CRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV 176
            C  +AE     T +++  VL       F  +     +      D+G Y CT    +    
Sbjct: 2321 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA---- 2376

Query: 177  SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL---ERSDVPLRFRFFRDDQ 233
             S +V  +V E  T P +R       SG P       Q +L   +   VP     +R D+
Sbjct: 2377 GSTSVAFRV-EIHTVPTIR-------SGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 2428

Query: 234  T----LGLGWSLSP--NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP 287
                     + + P  + +I  + ++D+G Y C A+    S  SD     ++V  P   P
Sbjct: 2429 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN---SAGSDRQGRDLRVLEP---P 2482

Query: 288  VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGA-----SIS 342
             +  SP        T   L CE    S + L  ++ +G  L     R ++GA     S +
Sbjct: 2483 AIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKL---DFRLQQGAYRLLPSNA 2538

Query: 343  FSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399
              LT    ++S  + C   N +G +  +   ++V VP   P +     +  +   A V L
Sbjct: 2539 LLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVHVP---PTIADDQTDFTVTMMAPVVL 2594

Query: 400  HCEAQRGSLPILYQFHHEGAALERRSA----NSAGGVAISFSLTAEHSGNYYCTADNGFG 455
             C +     P +  +   GA L  R +    + +G + I  +L   H+G Y C+A N  G
Sbjct: 2595 TCHSTGIPAPTV-SWSKAGAQLGARGSGYRVSPSGALEIGQALPI-HAGRYTCSARNSAG 2652

Query: 456  PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515
                         PV  P+ ++  A A       V L CE   G P+    +  E + + 
Sbjct: 2653 VAHKHVFLTVQASPVVKPLPSVVRAVA----EEEVLLPCEAS-GIPRPTITWQKEGLNVA 2707

Query: 516  SSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572
            +  +  V   G++  + +  E  +GNY C A N  G    +   L V VP   P++   +
Sbjct: 2708 TGVSTQVLPGGQLRIAHASPED-AGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGL 2762

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-SGGEASFNL--------- 622
            P      G    L C+A RGSP         ++T      P SG E  F +         
Sbjct: 2763 PDLSTTEGSHAFLPCKA-RGSP-------EPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2814

Query: 623  SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
            +L  + +G Y+C A N  V +    + L+++V    P+ T         +GD L L C A
Sbjct: 2815 NLEGQDAGTYTCTAENA-VGRARRRVHLTILV---LPVFTTLPGDRSLRLGDRLWLRCAA 2870

Query: 683  LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL-EAQRSEMV 741
                +P + W  ++      +S   GG      +++ E SG Y C A+N +   Q    V
Sbjct: 2871 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930

Query: 742  TLKVAVPVSRPVLTLRA-PGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800
             +K A     PVL   A       VG  ++L C  +RG P+    +  + + L  R S  
Sbjct: 2931 HVKEA-----PVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDIHWIKDGLPL--RGSHL 2982

Query: 801  GGASLNLSLT-----AEHSGNYSCEADNGLGAQRSETV 833
                 N SLT      + +G Y C A+N +G  +   +
Sbjct: 2983 RHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVI 3020



 Score =  106 bits (264), Expect = 1e-22
 Identities = 207/857 (24%), Positives = 326/857 (38%), Gaps = 83/857 (9%)

Query: 19   RTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY----LGKEILRETPDNI 74
            + P  I  L     T      V+L C      +P+ T WY       LG+E+      + 
Sbjct: 1652 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT-WYKDSQALSLGEEVFLLPGTHT 1710

Query: 75   LEV-----QESGEYRCQAQGSP--------LSSPVHLDFSSASLILQAPLSVFEGDSVVL 121
            L++      +SG Y C+A  +         LS  V   F  A    Q  + V  GD  VL
Sbjct: 1711 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1770

Query: 122  RCRAKAEVTLNNTIYKNDNVLAFLNKRTD-------FHIPHACLKDNGAYRCTGYKESCC 174
             C   A      T YK+   L  L +RT          I  A + D G Y C     +  
Sbjct: 1771 SCETDALPEPTVTWYKDGQPLV-LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829

Query: 175  PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
             V + T+ +QV   F  P  +  +   ++G+P+ LTC+       +   L+ R   +   
Sbjct: 1830 AVRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA 1887

Query: 235  LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294
            +    S     Q++ +    +G Y C A     +  +++ + ++   + A     +    
Sbjct: 1888 VHGVVSRGGRLQLSRLQPAQAGTYTCVAE----NTQAEARKDFVVAVLVAPRIRSSGVAR 1943

Query: 295  KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-----RHKSVRCERGASISFSLTTEN 349
            +    EG +V L CE        +  +  +G PL      H     + G+ +   L   +
Sbjct: 1944 EHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2002

Query: 350  SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLP 409
            +G Y C A N  G + ++  +++V VP +       S   +   G  VT+ C   RGS P
Sbjct: 2003 AGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPP 2060

Query: 410  ILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466
            I   +  +G  L   +R   + +G       +    +G + C A +  G    +  +L V
Sbjct: 2061 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQV 2119

Query: 467  TV-PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRV 525
             V PV  PV   +  + +   G+ V L CE  RG P  L  +  +  PL S S      +
Sbjct: 2120 QVPPVLEPVEFQN--DVVVVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLEQGPSL 2176

Query: 526  SFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV-GDLLE 584
                ++  G SG Y C A +  G  R       +TV     I     P   ++  G  +E
Sbjct: 2177 QLE-AVGAGDSGTYSCVAVSEAGEARRH---FQLTVMEPPHIEDSGQPTELSLTPGAPME 2232

Query: 585  LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644
            L C+A     P + W  H+D   G +       +     L    +G Y+C     L    
Sbjct: 2233 LLCDAQGTPQPNITW--HKD---GQALTRLENNSRATRVLRVRDAGLYTC-----LAESP 2282

Query: 645  SDTISLSVIVPVSRP--ILTFRAPR-AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701
            +  I  S  V V  P  I+  R PR    +    L L C      +P + W  H D  + 
Sbjct: 2283 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW--HRDGIVL 2340

Query: 702  KISA----PSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757
            +  A    P  G      +L+T  SG YSC A N   A  S  V  +V +  + P +   
Sbjct: 2341 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARN---AAGSTSVAFRVEIH-TVPTIRSG 2396

Query: 758  APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLTAE 812
             P  + +V     L C+A  G P  L  +  + V L  RS      P G   +   + A+
Sbjct: 2397 PPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ-PVLAQ 2454

Query: 813  HSGNYSCEADNGLGAQR 829
             +G+Y C A N  G+ R
Sbjct: 2455 DAGHYLCLASNSAGSDR 2471



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 213/899 (23%), Positives = 324/899 (36%), Gaps = 141/899 (15%)

Query: 34   VFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRE-----TPDNIL------EVQESGE 82
            V  G+   L C       P+ T W+    G+ + R      +PD +L       +  +G 
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLT-WFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGH 1231

Query: 83   YRCQAQGSPLSSPVHLDFSSASLILQAP-------------LSVFEGDSVVLRCRAKAEV 129
            Y C A  +      H   S    +L AP             ++V   + + L C A A  
Sbjct: 1232 YSCIAANAVGEKTKHFQLS----VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 1287

Query: 130  TLNNTIYKN------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
            + N T  K+         +  L       I +A  +D G Y C    E    V +  V++
Sbjct: 1288 SPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1347

Query: 184  QVQEPFTRP----VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ------ 233
             +    ++      +     +    + +TL CE+      +  P   R+++D Q      
Sbjct: 1348 LIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW-----AVPPPTIRWYKDGQPVTPSS 1402

Query: 234  ---TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQV-QIP 283
                LG G  L    QI      DSG Y C A  +       ++V+   P  + +V    
Sbjct: 1403 RLQVLGEGRLL----QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 1458

Query: 284  ASHPVLTLSPEKALNF-------EGTKVTLHCETQEDSLRTLYRFYHEGVPLR---HKSV 333
            A+  +L+   E            E     L+C+T       L  +Y E  PL      SV
Sbjct: 1459 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSV 1517

Query: 334  RCERGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392
              + G  +   L   EN+G Y C A N +G        L +T PV      L   E+L+ 
Sbjct: 1518 -LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-----LGDTEELVE 1571

Query: 393  E-----GAKVTLHCEAQRGSLPILYQFHH--EGAALERRSANSAGGVAISFSLTAEHSGN 445
            E      + V+L C A    +P +    +    +   R      G V    +     + +
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1631

Query: 446  YYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSPQIL 504
            Y C A+N  G    K  +L V VP     L L    A+    ++V+L C+V    +P++ 
Sbjct: 1632 YMCVAENQAG-SAEKLFTLRVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 1688

Query: 505  Y-------QFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSL 557
            +           E   L  + T  +GR   S       SG Y C A N  G +  ++V L
Sbjct: 1689 WYKDSQALSLGEEVFLLPGTHTLQLGRARLS------DSGMYTCEALNAAG-RDQKLVQL 1741

Query: 558  FVTVPVSRPILTLRVPRA--QAV---VGDLLELHCEAPRGSPPILYWFYHED--VTLGSS 610
             V VP +      + PR    AV   VGD   L CE      P + W+      V    +
Sbjct: 1742 SVLVPPA----FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 1797

Query: 611  SAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQA 670
             A  GG+            G YSC+ +N +  +   T +L+V VP      TF  P+ + 
Sbjct: 1798 QALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTVQVPP-----TFENPKTET 1851

Query: 671  ---VVGDLLELHCEALRGSSPILYWFYHE-DVTLGKISAPSGGGASFNLS-LTTEHSGIY 725
               V G  L L C+     +P + W      V    +      G    LS L    +G Y
Sbjct: 1852 VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTY 1911

Query: 726  SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785
            +C A+N     R + V   +  P  R     R    H   G  + L CEA  G P     
Sbjct: 1912 TCVAENTQAEARKDFVVAVLVAPRIRSSGVARE--HHVLEGQEVRLDCEA-DGQPPPDVA 1968

Query: 786  FFHEDVTLGNRSSP------SGGASLNLSLTAEHSGNYSCEADNGLGAQ-RSETVTLYI 837
            +  +   LG    P       GG+ +   L A  +G Y+C A N  G   R  TV + +
Sbjct: 1969 WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 2027



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 203/898 (22%), Positives = 328/898 (36%), Gaps = 136/898 (15%)

Query: 40   VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNIL------------EVQESGEYRCQA 87
            +TL C+      P   +W+    G+E +    D  L            + Q+SG Y C A
Sbjct: 1088 LTLLCEAMGI-PPPAIRWFR---GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1143

Query: 88   QGSPLSSPVHLDFSSASLI--------LQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKND 139
                 +     +FS   L+        L+  + V +G +  L C          T +K+ 
Sbjct: 1144 SNE--AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 1201

Query: 140  NVLAFLNKRTDFH----------IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPF 189
              LA    R D H          +  A L   G Y C         V   T   Q+    
Sbjct: 1202 RPLA----RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLL 1253

Query: 190  TRPVLRA---SSFQPIS---GNPVTLTCET------QLSLERSDVPLRFRFFRDDQTLGL 237
               +L     S+ + ++    NP++L CE        ++  +   P  F   R+ Q L  
Sbjct: 1254 APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPG 1311

Query: 238  GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPAS----HPVLTLS 292
               L    QI     +D+G Y C       + + ++ +++ ++V IP S     P+  + 
Sbjct: 1312 THGL----QILNAQKEDAGQYTCVVT----NELGEAVKNYHVEVLIPPSISKDDPLAEVG 1363

Query: 293  PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLT---TEN 349
             ++      + +TL CE+      T+ R+Y +G P+   S     G      +      +
Sbjct: 1364 VKEVKTKVNSTLTLECESWAVPPPTI-RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSD 1422

Query: 350  SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------------IFE 393
            SG Y C A N  G        L    P+   V + S+  ++                I E
Sbjct: 1423 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 1482

Query: 394  GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAEHSGNYYCTAD 451
                 L+C+      P L  +  +   +A +  S    G V     + AE++G Y C A 
Sbjct: 1483 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1542

Query: 452  NGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFE-----GATVTLHCEVQRGSPQILYQ 506
            N  G        L +T PV      L   E L  E      +TV+L C    G+P     
Sbjct: 1543 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTIS 1596

Query: 507  FYHEDMPLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPV 563
            +    +P   S    V   G+V    +     + +Y C A+N  G    ++ +L V VP 
Sbjct: 1597 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG-SAEKLFTLRVQVPP 1655

Query: 564  SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHED-VTLGSSSAPSGGEASFNL 622
               I  L + +  A++   + L C+      P + W+     ++LG       G  +  L
Sbjct: 1656 R--IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 1713

Query: 623  SLTA-EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR-APRA--QAV---VGDL 675
                   SG Y+CEA N    +    + LSV+VP +     FR APR    AV   VGD 
Sbjct: 1714 GRARLSDSGMYTCEALNA-AGRDQKLVQLSVLVPPA-----FRQAPRGPQDAVLVRVGDK 1767

Query: 676  LELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLS-LTTEHSGIYSCEADNGL 733
              L CE      P + W+   + + L + +    GG    +        G+YSC+  N  
Sbjct: 1768 AVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVA 1827

Query: 734  -EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792
             EA R+  +T++V      P    +        G  L L C+ + G P     +  + + 
Sbjct: 1828 GEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCD-VSGVPAPTVTWLKDRMP 1882

Query: 793  LGNRSSP---SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSG 846
            + + +     S G  L LS L    +G Y+C A+N     R + V   +       SG
Sbjct: 1883 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG 1940



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 102/392 (26%), Positives = 160/392 (40%), Gaps = 27/392 (6%)

Query: 348  ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407
            E++GNY C A N  G+   K   L V VP   PV+    P+    EG+   L C+A RGS
Sbjct: 2728 EDAGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGLPDLSTTEGSHAFLPCKA-RGS 2782

Query: 408  LPILYQFHHEG---AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464
                  +  +G   +  E +      G  +  +L  + +G Y CTA+N  G  R + V L
Sbjct: 2783 PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR-VHL 2841

Query: 465  SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGR 524
            ++ V    PV T    +     G  + L C   RGSP     +   D P+    +   G 
Sbjct: 2842 TILVL---PVFTTLPGDRSLRLGDRLWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDGG 2897

Query: 525  VSFS-FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583
             +    +++   SG Y C A+N  G  R++ VS FV V  +  +           VG  +
Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVG--RTQAVS-FVHVKEAPVLQGEAFSYLVEPVGGSI 2954

Query: 584  ELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGL- 640
            +L C   RG P P ++W        GS         S  +  T  + +G Y C A N + 
Sbjct: 2955 QLDCVV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMG 3013

Query: 641  VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFY-HEDVT 699
            VA+      + ++V  S P+            GD + L C+A    +P + W    + + 
Sbjct: 3014 VAK-----KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR 3068

Query: 700  LGKISAPSGGGASFNLSLTTEHSGIYSCEADN 731
              +       G+ +  ++ T  +G Y C A N
Sbjct: 3069 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3100



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 134/520 (25%), Positives = 188/520 (36%), Gaps = 84/520 (16%)

Query: 349  NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL 408
            + G Y C A N L  +  + V+L V VP   P +        + E A VTL C A     
Sbjct: 577  DEGIYTCAATN-LAGESKREVALKVLVP---PNIEPGPVNKAVLENASVTLECLASGVPP 632

Query: 409  PILYQF--HHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466
            P +  F  H   ++    + +  G V          +G+Y C A N  G    +   L V
Sbjct: 633  PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRV 691

Query: 467  TVPVSHPVLTLS-SAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV--- 522
             VP   P +TL  S          V L C    G+P     +  +  P+  + TP +   
Sbjct: 692  NVP---PRITLPPSLPGPVLVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVF 747

Query: 523  --GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVG 580
              GRV    S     SG Y C A +  G  R +VV L V +P   P +         V  
Sbjct: 748  PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMP---PSILGEELNVSVVAN 803

Query: 581  DLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHS----------- 629
            + + L C++    PP+L W+       G    P  G     + L+A+ +           
Sbjct: 804  ESVALECQSHAMPPPVLSWWKD-----GRPLEPRPG-----VHLSADKALLQVDRADVWD 853

Query: 630  -GNYSCEANNGLVAQHSDT-ISLSVIVPVSRPILTFRAPRAQAV-VGDLLELHCEALRGS 686
             G+Y+CEA N   A HS+   +L+V V    P+   R      V  G    L CE     
Sbjct: 854  AGHYTCEALNQ--AGHSEKHYNLNVWVA---PVFPLRESHTLTVREGHPTRLSCECRGVP 908

Query: 687  SPILYW------FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740
             P + W         E   L  +SA   G   +         G Y+CE  N +    S+ 
Sbjct: 909  FPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSN-VVGNSSQD 965

Query: 741  VTLKVAVPVSRPVLTLRAPGTHAAV--GDLLELHCEALRGSPLILYRFFHEDVTLGNRSS 798
            + L+V VP    +   R P T  +V    +  L C A    P               R  
Sbjct: 966  LQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPP---------PTVTWERDG 1014

Query: 799  PSGGASLNLSLT------------AEHSGNYSCEADNGLG 826
               GA L L L             A H+G YSC A+N  G
Sbjct: 1015 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1054



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 185/837 (22%), Positives = 290/837 (34%), Gaps = 141/837 (16%)

Query: 79   ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEV 129
            +SG Y C A      S V  D     L +  P         +SV   +SV L C++ A  
Sbjct: 762  DSGRYSCVAV-----SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMP 816

Query: 130  TLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183
                + +K+   L           +    +  A + D G Y C    ++        + +
Sbjct: 817  PPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876

Query: 184  QVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTL-GLGWSL 241
             V   F  P+  + +     G+P  L+CE +       VP  +  + +D Q L G G  L
Sbjct: 877  WVAPVF--PLRESHTLTVREGHPTRLSCECR------GVPFPKISWRKDGQPLPGEGAGL 928

Query: 242  SPNFQITAMWS------KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEK 295
                 +  +           G Y C+ + +   V + S    ++V +P         P +
Sbjct: 929  QHVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQ 985

Query: 296  ALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE------- 348
                +    TL C        T+  +  +G P+         GA +   L  +       
Sbjct: 986  VSVVQDGVATLECNATGKPPPTV-TWERDGQPV---------GAELGLQLQNQGQSLHVE 1035

Query: 349  -----NSGNYYCTADNGLGAKPSKAVSLSVTVPVS-----HPVLNLSSPEDLIFEGAKVT 398
                 ++G Y C A+N L  +  +   LSV VP        P+ N+++        + +T
Sbjct: 1036 RAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPELIGDLDPLTNITAALH-----SPLT 1089

Query: 399  LHCEAQRGSLPILYQFHHEGAALERRSANS-AGGVAISFSLTAEH-SGNYYCTADNGFGP 456
            L CEA     P +  F  E            AGG  +  + T E  SG Y C A N  G 
Sbjct: 1090 LLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE 1149

Query: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516
             R +  S+ V VP S     L     +  +G T  L C V  G PQ    ++ +  PL  
Sbjct: 1150 AR-RNFSVEVLVPPSIENEDLEEVIKV-LDGQTAHLMCNVT-GHPQPKLTWFKDGRPLAR 1206

Query: 517  SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572
                 +        + + +   +G+Y C A N  G +     +S+ +   +         
Sbjct: 1207 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1266

Query: 573  PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTA------ 626
                  V + + L CEA     P + W            AP   EAS N+ L        
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITWM--------KDGAPF--EASRNIQLLPGTHGLQ 1316

Query: 627  ------EHSGNYSCEANNGLVAQHSDTISLSVIVPVS----RPILTFRAPRAQAVVGDLL 676
                  E +G Y+C   N L  +      + V++P S     P+        +  V   L
Sbjct: 1317 ILNAQKEDAGQYTCVVTNEL-GEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTL 1375

Query: 677  ELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLSLT-TEHSGIYSCEADNGLE 734
             L CE+     P + W+   + VT        G G    +  T    SG Y C A N   
Sbjct: 1376 TLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1435

Query: 735  AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG----------SPLILY 784
                +   L    P+ + V      G  +A  ++L    EA  G          +P  LY
Sbjct: 1436 EDDQDFNVLIQVPPMFQKV------GDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489

Query: 785  -----------RFFHEDVTLGNRSSPS---GGASLNLSLT-AEHSGNYSCEADNGLG 826
                        ++ ED  L      S   GG  L + L  AE++G YSC+A N +G
Sbjct: 1490 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1546



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 188/748 (25%), Positives = 273/748 (36%), Gaps = 107/748 (14%)

Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPI-- 202
           L++    H P     D+G Y C    E+    +     + V  P +  VL A + Q +  
Sbjct: 83  LDEGQSLHFPRIQEGDSGLYSCRA--ENQAGTAQRDFHLLVLTPPS--VLGAGAAQEVLG 138

Query: 203 -SGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTLGLGWSLSPNFQ---------ITAMW 251
            +G  V L C T      S VP  +  + +D Q +  G    P+ Q         IT   
Sbjct: 139 LAGADVELQCWT------SGVPTPQVEWTKDRQPVLPG---GPHLQVQEDGQVLRITGSH 189

Query: 252 SKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE--KALNFEGTKVTLHCE 309
             D G Y C A    +S      R + Q+++ A  P +  S E  +    E   V L CE
Sbjct: 190 VGDEGRYQCVA----FSPAGQQARDF-QLRVHAP-PTIWGSNETGEVAVMEDHLVQLLCE 243

Query: 310 TQEDSLRTLYRFYHEG--VPLRHKSVRCERGASISFSLT-TENSGNYYCTADNGLGAKPS 366
            +      +  ++ +G  +P   K V    G  +      + ++G Y C A N +GA   
Sbjct: 244 ARGVPTPNI-TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA-E 301

Query: 367 KAVSLSVTVPVSHPVLNLSSPEDLIFE---GAKVTLHCEAQRGSLPILYQFHHEG--AAL 421
           KA  L V VP   P +  +     + +   G  V L C A+    P L  +HHEG   A 
Sbjct: 302 KATRLDVYVP---PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL-SWHHEGLPVAE 357

Query: 422 ERRSANSAGGVAISFSLTAE-HSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSS- 479
              S     G  +      E  SG Y C A +   P     +  SV V V   +L     
Sbjct: 358 SNESRLETDGSVLRLESPGEASSGLYSCVASS---PAGEAVLQYSVEVQVPPQLLVAEGL 414

Query: 480 AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP---LWSSSTPSVGRVSFSFSLTEGHS 536
            +  T  G  + L C+   GSP    Q+     P   L      S G       +   HS
Sbjct: 415 GQVTTIVGQPLELPCQAS-GSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHS 473

Query: 537 GNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPI 596
           G + C A N  G   +EV    V+V        L VP  Q   G   E H   P    P 
Sbjct: 474 GLFACQATNEAGTAGAEVE---VSVHGEWAPGVLEVPIGQYHWGX--EHHSSFPAACDPP 528

Query: 597 LY--WFYHEDVTLGSS--------SAPSGGEASFNL-------SLTAEHSGNYSCEANNG 639
           ++  W  H    L             P+G   +++L        +     G Y+C A N 
Sbjct: 529 VHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATN- 587

Query: 640 LVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDL-LELHCEALRGSSPILYWFY-HED 697
           L  +    ++L V+VP +        P  +AV+ +  + L C A     P + WF  H+ 
Sbjct: 588 LAGESKREVALKVLVPPNIE----PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 643

Query: 698 VTLGKISAPSGGGASFNLSLTT-EHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTL 756
           V+       S  G    +       +G Y C A N +         L+V VP  R  L  
Sbjct: 644 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELRYGLRVNVP-PRITLPP 701

Query: 757 RAPGTHAAVGDLLELHCEALRG-SPLILYRFFHEDVTLGNRSSPSGGASLNL-------- 807
             PG    V   + L C A    SP +++      +  GN  SP+G   L +        
Sbjct: 702 SLPGP-VLVNTPVRLTCNATGAPSPTLMW------LKDGNPVSPAGTPGLQVFPGGRVLT 754

Query: 808 --SLTAEHSGNYSCEADNGLGAQRSETV 833
             S  A  SG YSC A + +G  R + V
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVV 782



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 113/488 (23%), Positives = 193/488 (39%), Gaps = 39/488 (7%)

Query: 162  GAYRCTGYKESCCPVSSNTVKIQVQ-EPFTRPVLRASSFQPISGNPVTLTCETQLSLERS 220
            G Y C+    +   V+   V + VQ  P  +P+   S  + ++   V L CE    + R 
Sbjct: 2641 GRYTCSA--RNSAGVAHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEAS-GIPRP 2695

Query: 221  DVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWI 278
             +  +      +   G+   + P  Q+    +  +D+G Y C A     S +    ++ +
Sbjct: 2696 TITWQKEGL--NVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMG---KTRL 2750

Query: 279  QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRC 335
             VQ+P   PV+          EG+   L C+ +  S      +  +G P+     K    
Sbjct: 2751 VVQVP---PVIENGLPDLSTTEGSHAFLPCKAR-GSPEPNITWDKDGQPVSGAEGKFTIQ 2806

Query: 336  ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395
              G  +  +L  +++G Y CTA+N +G +  + V L++ V    PV      +  +  G 
Sbjct: 2807 PSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVL---PVFTTLPGDRSLRLGD 2862

Query: 396  KVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG 455
            ++ L C A+    P +    ++    E  S    G      +++ E SG Y C A+N  G
Sbjct: 2863 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 2922

Query: 456  PQRSKAVSLSVTVPVSHPVLTLSSAEALTFE--GATVTLHCEVQRGSPQILYQFYHEDMP 513
              R++AVS    V V    +    A +   E  G ++ L C V RG P     +  + +P
Sbjct: 2923 --RTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLP 2976

Query: 514  LWSSSTP-SVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLR 571
            L  S     +   S +   TE   +G Y C A+N  G  +  V    + V  S P+  + 
Sbjct: 2977 LRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVV----ILVLQSAPVFQVE 3032

Query: 572  VPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL-SLTAEHSG 630
                    GD + L C+A     P + W         S    +  + S  L ++    +G
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3092

Query: 631  NYSCEANN 638
             Y C A+N
Sbjct: 3093 TYDCVAHN 3100



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 40/314 (12%)

Query: 75   LEVQESGEYRCQAQGSP--LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVT 130
            LE Q++G Y C A+ +       VHL      +    P   S+  GD + LRC A+   T
Sbjct: 2816 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 2875

Query: 131  LNNTIYKNDNVLAFLNKRTD----FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQ 186
                   ND  +       D            +D+G Y C  + E+    +     + V+
Sbjct: 2876 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC--WAENRVGRTQAVSFVHVK 2933

Query: 187  EPFTRPVLRASSF----QPISGNPVTLTCETQ------LSLERSDVPLRFRFFRDDQTLG 236
            E    PVL+  +F    +P+ G+ + L C  +      +   +  +PLR    R     G
Sbjct: 2934 EA---PVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG 2989

Query: 237  LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296
                   +  I      D+G Y C A               + + +  S PV  + P+  
Sbjct: 2990 -------SLTIRRTERDDAGRYQCLAEN------EMGVAKKVVILVLQSAPVFQVEPQDM 3036

Query: 297  LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRCERGASISF-SLTTENSGNYY 354
                G  V L C+   +   T+  +   G PLR  + +R     S+   ++ T ++G Y 
Sbjct: 3037 TVRSGDDVALRCQATGEPTPTI-EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 3095

Query: 355  CTADNGLGAKPSKA 368
            C A N LG+  ++A
Sbjct: 3096 CVAHNLLGSATARA 3109



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 9/74 (12%)

Query: 802 GASLNLSLTAE-HSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIA 860
           G SL+     E  SG YSC A+N  G  + +   L +T        P +   AG    + 
Sbjct: 86  GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT--------PPSVLGAGAAQEVL 137

Query: 861 GLAAGALLLYCWLS 874
           GLA   + L CW S
Sbjct: 138 GLAGADVELQCWTS 151


>gi|189083842 Fc fragment of IgG, low affinity IIIa, receptor
           (CD16a) isoform d precursor [Homo sapiens]
          Length = 253

 Score =  106 bits (264), Expect = 1e-22
 Identities = 89/271 (32%), Positives = 128/271 (47%), Gaps = 35/271 (12%)

Query: 3   LWVILL----VLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTK 56
           +W +LL    +L   +G     P+ ++FL+P W  V + + VTL C+G   YSP+   T+
Sbjct: 1   MWQLLLPTALLLLVSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQ 58

Query: 57  WYHRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS 112
           W+H    + ++     +       V +SGEYRCQ   S LS PV L+     L+LQAP  
Sbjct: 59  WFH---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRW 115

Query: 113 VF-EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYK 170
           VF E D + LRC +     L+   Y +N     + +  +DF+IP A LKD+G+Y C G  
Sbjct: 116 VFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLF 175

Query: 171 ESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFR 230
            S   VSS TV I + +     V   SSF P  G  V+  C   + L   D         
Sbjct: 176 GS-KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT-------- 222

Query: 231 DDQTLGLGWSLSPNFQITAMWSKDSGFYWCK 261
                GL +S+  N + +    KD  F W K
Sbjct: 223 -----GLYFSVKTNIRSSTRDWKDHKFKWRK 248



 Score = 33.5 bits (75), Expect = 1.00
 Identities = 44/203 (21%), Positives = 91/203 (44%), Gaps = 19/203 (9%)

Query: 92  LSSPVHLDFSSASLILQAP-LSVFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRT 149
           +S+ +  D   A + L+     V E DSV L+C+       N+T  + N+++++  ++ +
Sbjct: 14  VSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQAS 71

Query: 150 DFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTL 209
            + I  A + D+G YRC    ++     S+ V+++V   +   +L+A  +     +P+ L
Sbjct: 72  SYFIDAATVDDSGEYRC----QTNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHL 125

Query: 210 TCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSV 269
            C +  +     V      +  +      +  + +F I     KDSG Y+C+      +V
Sbjct: 126 RCHSWKNTALHKVT-----YLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNV 180

Query: 270 ISDSPRSWIQVQIPASHPVLTLS 292
            S++    + + I     V T+S
Sbjct: 181 SSET----VNITITQGLAVSTIS 199


>gi|4503675 Fc fragment of IgE, high affinity I, receptor for; alpha
           polypeptide precursor [Homo sapiens]
          Length = 257

 Score =  103 bits (257), Expect = 8e-22
 Identities = 64/173 (36%), Positives = 90/173 (52%), Gaps = 10/173 (5%)

Query: 2   LLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY 61
           LL V LL  AP  G  A   +P + L PPW  +F+GE VTLTC G  F+    TKW+H  
Sbjct: 10  LLCVALLFFAP-DGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFH-- 66

Query: 62  LGKEILRETPDNI----LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS-VFEG 116
               +  ET  ++     + ++SGEY+CQ Q    S PV+L+  S  L+LQA    V EG
Sbjct: 67  -NGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEG 125

Query: 117 DSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTG 168
             + LRC       +   I YK+   L +  +  +  I +A ++D+G Y CTG
Sbjct: 126 QPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTG 178



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 22/181 (12%)

Query: 113 VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172
           +F+G++V L C       +++T + ++  L+     +  +I +A  +D+G Y+C   + +
Sbjct: 41  IFKGENVTLTCNGNNFFEVSSTKWFHNGSLSE-ETNSSLNIVNAKFEDSGEYKCQHQQVN 99

Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232
                S  V ++V   +   +L+AS+   + G P+ L C         DV  +  +++D 
Sbjct: 100 ----ESEPVYLEVFSDWL--LLQASAEVVMEGQPLFLRCH---GWRNWDV-YKVIYYKDG 149

Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWC--KAATMPYS------VISDSPRS--WIQVQI 282
           + L   W  + N  IT    +DSG Y+C  K   + Y        +  +PR   W+Q  I
Sbjct: 150 EALKY-WYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFI 208

Query: 283 P 283
           P
Sbjct: 209 P 209



 Score = 37.0 bits (84), Expect = 0.090
 Identities = 46/165 (27%), Positives = 69/165 (41%), Gaps = 19/165 (11%)

Query: 380 PVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLT 439
           P ++L+ P + IF+G  VTL C           ++ H G +L   + +S   V   F   
Sbjct: 30  PKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNG-SLSEETNSSLNIVNAKF--- 85

Query: 440 AEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRG 499
            E SG Y C          S+ V L V    S  +L  +SAE +  EG  + L C   R 
Sbjct: 86  -EDSGEYKCQHQQ---VNESEPVYLEV---FSDWLLLQASAE-VVMEGQPLFLRCHGWRN 137

Query: 500 SP--QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCT 542
               +++Y    E +  W  +      +S + +  E  SG YYCT
Sbjct: 138 WDVYKVIYYKDGEALKYWYEN----HNISITNATVE-DSGTYYCT 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,044,295
Number of Sequences: 37866
Number of extensions: 1946179
Number of successful extensions: 8722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 277
Number of HSP's that attempted gapping in prelim test: 5143
Number of HSP's gapped (non-prelim): 2116
length of query: 977
length of database: 18,247,518
effective HSP length: 112
effective length of query: 865
effective length of database: 14,006,526
effective search space: 12115644990
effective search space used: 12115644990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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