BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|157694526 Fc receptor-like 5 [Homo sapiens] (977 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|157694526 Fc receptor-like 5 [Homo sapiens] 1974 0.0 gi|21314764 Fc receptor-like 3 precursor [Homo sapiens] 452 e-127 gi|14550416 Fc receptor-like 4 precursor [Homo sapiens] 319 7e-87 gi|19923629 Fc receptor-like 2 precursor [Homo sapiens] 293 4e-79 gi|226958551 Fc receptor-like 1 isoform 3 precursor [Homo sapiens] 242 1e-63 gi|16418419 Fc receptor-like 1 isoform 1 precursor [Homo sapiens] 240 4e-63 gi|226958547 Fc receptor-like 1 isoform 2 precursor [Homo sapiens] 207 4e-53 gi|50878302 Fc receptor-like B [Homo sapiens] 166 1e-40 gi|10835133 Fc fragment of IgG, high affinity Ia, receptor (CD64... 157 5e-38 gi|157057547 Fc receptor-like 6 [Homo sapiens] 133 7e-31 gi|69885149 Fc receptor-like and mucin-like 1 [Homo sapiens] 124 6e-28 gi|110349719 titin isoform N2-A [Homo sapiens] 113 1e-24 gi|50511926 Fc fragment of IgG, low affinity IIb, receptor isofo... 112 2e-24 gi|50511930 Fc fragment of IgG, low affinity IIb, receptor isofo... 112 2e-24 gi|118572606 hemicentin 1 [Homo sapiens] 112 2e-24 gi|126116592 Fc fragment of IgG, low affinity IIc, receptor [Hom... 111 3e-24 gi|132814489 low affinity immunoglobulin gamma Fc region recepto... 110 6e-24 gi|110347451 platelet/endothelial cell adhesion molecule [Homo s... 109 1e-23 gi|50511928 Fc fragment of IgG, low affinity IIb, receptor isofo... 108 3e-23 gi|50511932 Fc fragment of IgG, low affinity IIb, receptor isofo... 108 3e-23 gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 107 4e-23 gi|189083840 Fc fragment of IgG, low affinity IIIa, receptor (CD... 107 7e-23 gi|189083838 Fc fragment of IgG, low affinity IIIa, receptor (CD... 107 7e-23 gi|189083836 Fc fragment of IgG, low affinity IIIa, receptor (CD... 107 7e-23 gi|50726979 Fc fragment of IgG, low affinity IIIa, receptor (CD1... 107 7e-23 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 107 7e-23 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 107 7e-23 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 107 7e-23 gi|189083842 Fc fragment of IgG, low affinity IIIa, receptor (CD... 106 1e-22 gi|4503675 Fc fragment of IgE, high affinity I, receptor for; al... 103 8e-22 >gi|157694526 Fc receptor-like 5 [Homo sapiens] Length = 977 Score = 1974 bits (5115), Expect = 0.0 Identities = 977/977 (100%), Positives = 977/977 (100%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR Sbjct: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 Query: 61 YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120 YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV Sbjct: 61 YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120 Query: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT Sbjct: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180 Query: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS Sbjct: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240 Query: 241 LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE 300 LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE Sbjct: 241 LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE 300 Query: 301 GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG 360 GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG Sbjct: 301 GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG 360 Query: 361 LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA 420 LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA Sbjct: 361 LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA 420 Query: 421 LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA 480 LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA Sbjct: 421 LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA 480 Query: 481 EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY 540 EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY Sbjct: 481 EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY 540 Query: 541 CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF 600 CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF Sbjct: 541 CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF 600 Query: 601 YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI 660 YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI Sbjct: 601 YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI 660 Query: 661 LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE 720 LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE Sbjct: 661 LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE 720 Query: 721 HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP 780 HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP Sbjct: 721 HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP 780 Query: 781 LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL 840 LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL Sbjct: 781 LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL 840 Query: 841 TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH 900 TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH Sbjct: 841 TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH 900 Query: 901 NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA 960 NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA Sbjct: 901 NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA 960 Query: 961 STPVSGSLFLASSAPHR 977 STPVSGSLFLASSAPHR Sbjct: 961 STPVSGSLFLASSAPHR 977 >gi|21314764 Fc receptor-like 3 precursor [Homo sapiens] Length = 734 Score = 452 bits (1163), Expect = e-127 Identities = 257/567 (45%), Positives = 332/567 (58%), Gaps = 11/567 (1%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ-KTKWYH 59 MLLW++LL+L P Q P+ ++ L PPW+T F+GE+V L C Q T WYH Sbjct: 1 MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYH 60 Query: 60 RYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSV 119 +++L+ D I ++ E G Y+C+ +GS LS VH++FS LILQA VFEGD+V Sbjct: 61 ---DEKLLKIKHDKI-QITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNV 116 Query: 120 VLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCC---PV 176 +LRC+ K + +Y D + + ++ +DN Y CT Y++ V Sbjct: 117 ILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEV 176 Query: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236 +S + IQVQE F PVLRASS PI G+P+TLTCETQLS +R DV L+F FRD QTLG Sbjct: 177 TSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLG 236 Query: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ-IPASHPVLTLSPEK 295 LGWS SP QI AMW++DSG YWC+ T+ +S+ S RS I+VQ +P S+ L + P Sbjct: 237 LGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTG 296 Query: 296 ALNFEGTKVTLHCETQEDSLRTLYRFYHEG--VPLRHKSVRCERGASISFSLTTENSGNY 353 EG + L C + S + ++ EG L K+ R ++ ++G Y Sbjct: 297 GQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRY 356 Query: 354 YCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQ 413 YC ADN S + ++V +PVSHPVL +P G + LHCE+ RGS PILY+ Sbjct: 357 YCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYR 416 Query: 414 FHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHP 473 F+HE L SA S GG + + SLTAEHSGNY C ADNG G Q S VSL VTVPVS P Sbjct: 417 FYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRP 476 Query: 474 VLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTE 533 VLTL + A G + LHCE RGS ILY FYHED L + S S G SF+ SLT Sbjct: 477 VLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTT 536 Query: 534 GHSGNYYCTADNGFGPQRSEVVSLFVT 560 HSGNY C ADNG G Q S+VV+L VT Sbjct: 537 EHSGNYSCEADNGLGAQHSKVVTLNVT 563 Score = 420 bits (1079), Expect = e-117 Identities = 294/711 (41%), Positives = 383/711 (53%), Gaps = 70/711 (9%) Query: 284 ASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRF-YHEGVPLRHKSVRCERGASIS 342 A VL L+P + F+G KV L C + SL + YH+ L+ K + + Sbjct: 20 APKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQ------ 73 Query: 343 FSLTTENSGNYYCTADNGLGAKPSKAVSLSVT-----VPVSHPVLNLSSPEDLIFEGAKV 397 GNY C G+ S AV + + + HPV FEG V Sbjct: 74 ----ITEPGNYQCKTR---GSSLSDAVHVEFSPDWLILQALHPV----------FEGDNV 116 Query: 398 TLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG-- 455 L C+ + ++ +G L NS I+ + + + Y+CTA F Sbjct: 117 ILRCQGKDNKNTHQKVYYKDGKQLP----NSYNLEKITVNSVSRDNSKYHCTAYRKFYIL 172 Query: 456 --PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ----RGSPQILYQFYH 509 SK +++ V HPVL SS+ + EG+ +TL CE Q R Q+ + + Sbjct: 173 DIEVTSKPLNIQVQELFLHPVLRASSSTPI--EGSPMTLTCETQLSPQRPDVQLQFSLFR 230 Query: 510 EDMPL---WSSSTPSVGRVSFSFSLTEGHSGNYYC---TADNGFGPQRSEVVSLFVTVPV 563 + L WS S R+ TE SG+Y+C T + + VPV Sbjct: 231 DSQTLGLGWSRSP----RLQIPAMWTED-SGSYWCEVETVTHSIKKRSLRSQIRVQRVPV 285 Query: 564 SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDV--TLGSSSAPSGGEASFN 621 S L +R Q + G+ + L C +GS + + ++ E +LG + S Sbjct: 286 SNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHV 345 Query: 622 LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681 L++ +G Y C A+N S I ++V +PVS P+LTFRAPRA VVGDLLELHCE Sbjct: 346 LTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCE 405 Query: 682 ALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMV 741 +LRGS PILY FYHEDVTLG SAPSGGGASFNLSLT EHSG YSC+ADNGL AQ S V Sbjct: 406 SLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGV 465 Query: 742 TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS- 800 +L+V VPVSRPVLTLRAPG A VGDLLELHCE+LRGS ILY F+HED TLGN S+ S Sbjct: 466 SLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSG 525 Query: 801 GGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIA 860 GGAS NLSLT EHSGNYSCEADNGLGAQ S+ VTL +TG + NR+G A G+ G +LSI Sbjct: 526 GGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSIL 585 Query: 861 GLAAGALLL-YCWLSRKAGRKPAS-----------DPARS-PSDSDSQEPTYHNVPAWEE 907 LAA A LL Y RK G A+ +P+ S PS D QEPT+ A E Sbjct: 586 VLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPME 645 Query: 908 LQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVK 958 L+P+Y+N NP N +YS++ IQ K+++ H ++ ++YSE+K Sbjct: 646 LEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELK 696 Score = 371 bits (953), Expect = e-102 Identities = 237/537 (44%), Positives = 308/537 (57%), Gaps = 36/537 (6%) Query: 254 DSGFYWCKA--ATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQ 311 + G Y CK +++ +V + W+ +Q A HPV FEG V L C+ + Sbjct: 76 EPGNYQCKTRGSSLSDAVHVEFSPDWLILQ--ALHPV----------FEGDNVILRCQGK 123 Query: 312 EDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSL 371 ++ +Y +G L + S E+ I+ + + ++ Y+CTA + S Sbjct: 124 DNKNTHQKVYYKDGKQLPN-SYNLEK---ITVNSVSRDNSKYHCTAYRKFYILDIEVTSK 179 Query: 372 SVTVPVS----HPVLNLSSPEDLIFEGAKVTLHCEAQ----RGSLPILYQFHHEGAALER 423 + + V HPVL SS + EG+ +TL CE Q R + + + + L Sbjct: 180 PLNIQVQELFLHPVLRASSSTPI--EGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGL 237 Query: 424 RSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV---PVSHPVLTLSSA 480 + S + I ++ E SG+Y+C + + +++ + V PVS+ L + Sbjct: 238 GWSRSPR-LQIP-AMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPT 295 Query: 481 EALTFEGATVTLHCEVQRGSPQILYQFYHEDM--PLWSSSTPSVGRVSFSFSLTEGHSGN 538 EG + L C V +GS + + ++ E L + S+ ++ E +G Sbjct: 296 GGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGR 355 Query: 539 YYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY 598 YYC ADN P S + + V +PVS P+LT R PRA VVGDLLELHCE+ RGSPPILY Sbjct: 356 YYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILY 415 Query: 599 WFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSR 658 FYHEDVTLG+SSAPSGG ASFNLSLTAEHSGNYSC+A+NGL AQHS +SL V VPVSR Sbjct: 416 RFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSR 475 Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLT 718 P+LT RAP AQAVVGDLLELHCE+LRGS PILYWFYHED TLG ISA SGGGASFNLSLT Sbjct: 476 PVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLT 535 Query: 719 TEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEA 775 TEHSG YSCEADNGL AQ S++VTL V SR L A G V +L L A Sbjct: 536 TEHSGNYSCEADNGLGAQHSKVVTLNV-TGTSRNRTGLTAAGITGLVLSILVLAAAA 591 >gi|14550416 Fc receptor-like 4 precursor [Homo sapiens] Length = 515 Score = 319 bits (818), Expect = 7e-87 Identities = 177/379 (46%), Positives = 226/379 (59%), Gaps = 6/379 (1%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW LL APV GQ A +P+I + PPWTT F+GERVTLTC GF+FY+ +KT WYHR Sbjct: 1 MLLWASLLAFAPVCGQSAAAHKPVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHR 60 Query: 61 YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120 + E L TP N LEV+ESG YRCQA+GSP S+PV L FSS SLILQAP SVFEGD++V Sbjct: 61 HYWGEKLTLTPGNTLEVRESGLYRCQARGSPRSNPVRLLFSSDSLILQAPYSVFEGDTLV 120 Query: 121 LRCRAKAEVTLNNTIYK-NDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSN 179 LRC + + L Y N N+L+ NK D IP A +NG YRC GY + SN Sbjct: 121 LRCHRRRKEKLTAVKYTWNGNILSISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSN 180 Query: 180 TVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW 239 I++QE F P L+A+ QP GN V L+CETQL ERSD PL F FFRD + + W Sbjct: 181 FKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVILSDW 240 Query: 240 SLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ-IPASHPVLTLSPEKALN 298 S P Q+ +W ++SG YWC A T+ ++ SP I VQ IP S +L P Sbjct: 241 STYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQA 300 Query: 299 FEGTKVTLHCETQEDSLRTLYRFYHEGV--PLRHKSVRCERGASISFSLTTENSGNYYCT 356 EG + L C E + T + ++ E + L K+ R R ++ ++G YYCT Sbjct: 301 VEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCT 360 Query: 357 ADNGLGAKPSKAVSLSVTV 375 ADN G P +++ L+VTV Sbjct: 361 ADNSYG--PVQSMVLNVTV 377 Score = 129 bits (324), Expect = 1e-29 Identities = 142/508 (27%), Positives = 220/508 (43%), Gaps = 55/508 (10%) Query: 473 PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFS--FS 530 PV+++ F+G VTL C +QFY + W +++ + + Sbjct: 23 PVISVHPPWTTFFKGERVTLTCNG--------FQFYATEKTTWYHRHYWGEKLTLTPGNT 74 Query: 531 LTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAP 590 L SG Y C A G RS V L S L L+ P + GD L L C Sbjct: 75 LEVRESGLYRCQAR---GSPRSNPVRLLF----SSDSLILQAPYS-VFEGDTLVLRCHRR 126 Query: 591 RGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSL---TAEHSGNYSCEA---NNGLVAQH 644 R + L S+ S++L + ++ ++GNY C N + + Sbjct: 127 RKEKLTAVKYTWNGNILSISNK------SWDLLIPQASSNNNGNYRCIGYGDENDVFRSN 180 Query: 645 SDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEAL----RGSSPILYWFYHE-DVT 699 I + + P P L +A +Q G+ + L CE R +P+ + F+ + +V Sbjct: 181 FKIIKIQELFP--HPEL--KATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVI 236 Query: 700 LGKISAPSGGGASFNLSLTT---EHSGIYSCEADN--GLEAQRSEMVTLKVA-VPVSRPV 753 L S L L T E+SG Y C A+ G + S + + V +PVS + Sbjct: 237 LSDWSTYP------ELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVL 290 Query: 754 LTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDV--TLGNRSSPSGGASLNL-SLT 810 L + G A G++L L C G+ + + ED+ +LG ++ S A L L ++ Sbjct: 291 LETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIR 350 Query: 811 AEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLY 870 H+G Y C ADN G +S + + + NR G A G GGLLS A L A ALL + Sbjct: 351 QSHAGGYYCTADNSYGPVQSMVLNVTVRETPGNRDGLVAAGATGGLLS-ALLLAVALLFH 409 Query: 871 CWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRII 930 CW RK+G D R P E ++ PA ELQ +Y + +P+ ++VYSE++ Sbjct: 410 CWRRRKSGVGFLGDETRLPPAPGPGESSHSICPAQVELQSLYVDVHPKKGDLVYSEIQTT 469 Query: 931 QEKKKHAVASDPRHLRNKGSPIIYSEVK 958 Q ++ + L +K ++YSEVK Sbjct: 470 QLGEEEEANTSRTLLEDKDVSVVYSEVK 497 Score = 87.0 bits (214), Expect = 8e-17 Identities = 95/375 (25%), Positives = 156/375 (41%), Gaps = 53/375 (14%) Query: 204 GNPVTLTCETQLSLERSDVPLRFRFFRDDQTL-------GLGWSLSPNFQITAMWSKDSG 256 G VTLTC F+F+ ++T G +L+P + ++SG Sbjct: 37 GERVTLTCNG------------FQFYATEKTTWYHRHYWGEKLTLTPGNTLEV---RESG 81 Query: 257 FYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLR 316 Y C+A SPRS + +S ++ +P FEG + L C + Sbjct: 82 LYRCQAR--------GSPRSNPVRLLFSSDSLILQAPYSV--FEGDTLVLRCHRRRKEKL 131 Query: 317 TLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTA---DNGLGAKPSKAVSLSV 373 T ++ G L S+ + + ++ N+GNY C +N + K + + Sbjct: 132 TAVKYTWNGNIL---SISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSNFKIIKIQE 188 Query: 374 TVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQ----RGSLPILYQFHHEGAALERRSANSA 429 P HP L + + EG V L CE Q R P+ + F +G + S S Sbjct: 189 LFP--HPELKATDSQPT--EGNSVNLSCETQLPPERSDTPLHFNFFRDGEVI--LSDWST 242 Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV---PVSHPVLTLSSAEALTFE 486 ++ E+SG+Y+C A+ G + SL + V PVS +L + E Sbjct: 243 YPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQAVE 302 Query: 487 GATVTLHCEVQRGSPQILYQFYHEDM--PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTAD 544 G + L C V G+ + ++ EDM L + S+ ++ + H+G YYCTAD Sbjct: 303 GEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCTAD 362 Query: 545 NGFGPQRSEVVSLFV 559 N +GP +S V+++ V Sbjct: 363 NSYGPVQSMVLNVTV 377 Score = 83.2 bits (204), Expect = 1e-15 Identities = 95/389 (24%), Positives = 159/389 (40%), Gaps = 57/389 (14%) Query: 380 PVLNLSSPEDLIFEGAKVTLHC---EAQRGSLPILYQFHHEGAALERRSANSAGGVAISF 436 PV+++ P F+G +VTL C + Y H+ G L N Sbjct: 23 PVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHRHYWGEKLTLTPGN--------- 73 Query: 437 SLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEAL-------TFEGAT 489 +L SG Y C A P S+PV L S+++L FEG T Sbjct: 74 TLEVRESGLYRCQARGS---------------PRSNPVRLLFSSDSLILQAPYSVFEGDT 118 Query: 490 VTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHS---GNYYCTADNG 546 + L C +R ++ W+ + S+ S+ + + S GNY C G Sbjct: 119 LVLRCHRRRKEKLTAVKY------TWNGNILSISNKSWDLLIPQASSNNNGNYRCI---G 169 Query: 547 FGPQRSEVVSLFVTVPVSR--PILTLRVPRAQAVVGDLLELHCEA---PRGSPPILYWFY 601 +G + S F + + P L+ +Q G+ + L CE P S L++ + Sbjct: 170 YGDENDVFRSNFKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNF 229 Query: 602 HEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSC--EANNGLVAQHSDTISLSV-IVPVSR 658 D + S + E ++ E+SG+Y C E G + +HS ++ + V +PVS Sbjct: 230 FRDGEVILSDWSTYPELQLP-TVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSG 288 Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDV--TLGKISAPSGGGASFNLS 716 +L + QAV G++L L C G+ + ++ ED+ +LG+ + S + Sbjct: 289 VLLETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPA 348 Query: 717 LTTEHSGIYSCEADNGLEAQRSEMVTLKV 745 + H+G Y C ADN +S ++ + V Sbjct: 349 IRQSHAGGYYCTADNSYGPVQSMVLNVTV 377 Score = 68.6 bits (166), Expect = 3e-11 Identities = 78/324 (24%), Positives = 135/324 (41%), Gaps = 38/324 (11%) Query: 158 LKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL 217 ++++G YRC SN V++ ++ + + G+ + L C + Sbjct: 77 VRESGLYRCQARGSP----RSNPVRLLFSSD---SLILQAPYSVFEGDTLVLRCHRR--- 126 Query: 218 ERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRS- 276 R + ++ + L + + S + I S ++G Y C + Y +D RS Sbjct: 127 -RKEKLTAVKYTWNGNILSIS-NKSWDLLIPQASSNNNGNYRC----IGYGDENDVFRSN 180 Query: 277 --WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRT----LYRFYHEGVPLRH 330 I++Q HP L + + EG V L CETQ R+ + F+ +G Sbjct: 181 FKIIKIQELFPHPELKATDSQPT--EGNSVNLSCETQLPPERSDTPLHFNFFRDG----- 233 Query: 331 KSVRCERGASISFSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTV---PVSHPVLNL 384 + + + L T ENSG+Y+C A+ G + SL + V PVS +L Sbjct: 234 EVILSDWSTYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLET 293 Query: 385 SSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGA--ALERRSANSAGGVAISFSLTAEH 442 EG + L C G+ + +H E +L R++ S ++ H Sbjct: 294 QPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSH 353 Query: 443 SGNYYCTADNGFGPQRSKAVSLSV 466 +G YYCTADN +GP +S ++++V Sbjct: 354 AGGYYCTADNSYGPVQSMVLNVTV 377 >gi|19923629 Fc receptor-like 2 precursor [Homo sapiens] Length = 508 Score = 293 bits (751), Expect = 4e-79 Identities = 172/371 (46%), Positives = 221/371 (59%), Gaps = 5/371 (1%) Query: 104 SLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNV-LAFLNKRTDFHIPHACLKDNG 162 SL L AP SVFEGDS+VL+C+ + + Y DN L+ K +DF I A L D+G Sbjct: 19 SLTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSG 78 Query: 163 AYRC-TGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSD 221 Y C T + +SN VKI+VQE F RPVL ASSFQPI G PV+L CET+LS +R D Sbjct: 79 NYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLD 138 Query: 222 VPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ 281 V L+F FFR++Q LG GWS SP QI+A+WS+D+G YWCKA T+ + + S +S I VQ Sbjct: 139 VQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQ 198 Query: 282 -IPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHE--GVPLRHKSVRCERG 338 IP S+ L + EG K+ L C + + +Y E G + K+ R Sbjct: 199 RIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSA 258 Query: 339 ASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVT 398 ++ ++G YYC ADNG SK V++ V +PVS PVL L SP G + Sbjct: 259 ELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLE 318 Query: 399 LHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQR 458 LHCEA RGS PILYQF+HE L SA S GG + + SLTAEHSGNY C A+NG G Q Sbjct: 319 LHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQC 378 Query: 459 SKAVSLSVTVP 469 S+AV +S++ P Sbjct: 379 SEAVPVSISGP 389 Score = 275 bits (703), Expect = 2e-73 Identities = 197/499 (39%), Positives = 265/499 (53%), Gaps = 36/499 (7%) Query: 480 AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF---SLTEGHS 536 A + FEG ++ L C+ ++ +I YH+D + SV + F S S Sbjct: 24 APSSVFEGDSIVLKCQGEQNW-KIQKMAYHKD-----NKELSVFKKFSDFLIQSAVLSDS 77 Query: 537 GNYYCTADNGF--GPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSP 594 GNY+C+ + S +V + V RP+LT Q + G + L CE R SP Sbjct: 78 GNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLT--ASSFQPIEGGPVSLKCET-RLSP 134 Query: 595 PIL-----YWFYHEDVTLGSSSAPSGGEASFNLSLTA---EHSGNYSCEANNGLVAQHSD 646 L + F+ E+ LGS G +S L ++A E +G+Y C+A Sbjct: 135 QRLDVQLQFCFFRENQVLGS-----GWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQ 189 Query: 647 TISLSVIV---PVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHE--DVTLG 701 ++ + V P+S L RAP Q G L L C G+ + + +Y E ++G Sbjct: 190 SLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMG 249 Query: 702 KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGT 761 K + S ++ +G Y C ADNG +S++V + V +PVSRPVLTLR+PG Sbjct: 250 KKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGA 309 Query: 762 HAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGG-ASLNLSLTAEHSGNYSCE 820 AAVGDLLELHCEALRGSP ILY+F+HEDVTLGN S+PSGG AS NLSLTAEHSGNYSCE Sbjct: 310 QAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCE 369 Query: 821 ADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRK 880 A+NGLGAQ SE V + I+G R GV GL + G ALLLY + +G Sbjct: 370 ANNGLGAQCSEAVPVSISGPDGYRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGES 429 Query: 881 PASDPARSPSDSDSQEPTYHN-VPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVA 939 A++ R S + QE TY + P EELQPVY N +VVYS+V +Q+ + + A Sbjct: 430 SATNEPRGASRPNPQEFTYSSPTPDMEELQPVYVNVGSVDVDVVYSQVWSMQQPE--SSA 487 Query: 940 SDPRHLRNKGSPIIYSEVK 958 + L NK S +IYS VK Sbjct: 488 NIRTLLENKDSQVIYSSVK 506 Score = 226 bits (576), Expect = 8e-59 Identities = 147/368 (39%), Positives = 207/368 (56%), Gaps = 18/368 (4%) Query: 299 FEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTAD 358 FEG + L C+ +++ ++ + L SV + + S +SGNY+C+ Sbjct: 29 FEGDSIVLKCQGEQNWKIQKMAYHKDNKEL---SVFKKFSDFLIQSAVLSDSGNYFCSTK 85 Query: 359 NGLGA--KPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEA----QRGSLPILY 412 L K S V + V PVL SS + + EG V+L CE QR + + + Sbjct: 86 GQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPI--EGGPVSLKCETRLSPQRLDVQLQF 143 Query: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV---P 469 F E L +S+ + IS ++ +E +G+Y+C A+ R +++ + V P Sbjct: 144 CFFRENQVLGS-GWSSSPELQIS-AVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQRIP 201 Query: 470 VSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHE--DMPLWSSSTPSVGRVSF 527 +S+ L + + EG + L C V G+ + + +Y E + + S+ Sbjct: 202 ISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSAELE 261 Query: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587 ++ E +G YYC ADNG P +S+VV++ V +PVSRP+LTLR P AQA VGDLLELHC Sbjct: 262 IPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHC 321 Query: 588 EAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDT 647 EA RGSPPILY FYHEDVTLG+SSAPSGG ASFNLSLTAEHSGNYSCEANNGL AQ S+ Sbjct: 322 EALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEA 381 Query: 648 ISLSVIVP 655 + +S+ P Sbjct: 382 VPVSISGP 389 Score = 218 bits (556), Expect = 2e-56 Identities = 162/437 (37%), Positives = 220/437 (50%), Gaps = 31/437 (7%) Query: 382 LNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAE 441 L L +P +FEG + L C+ ++ +H + L S + S Sbjct: 20 LTLVAPSS-VFEGDSIVLKCQGEQNWKIQKMAYHKDNKEL---SVFKKFSDFLIQSAVLS 75 Query: 442 HSGNYYCTADNGF--GPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEV--- 496 SGNY+C+ + S V + V PVLT SS + + EG V+L CE Sbjct: 76 DSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPI--EGGPVSLKCETRLS 133 Query: 497 -QRGSPQILYQFYHEDMPLWS--SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSE 553 QR Q+ + F+ E+ L S SS+P + ++S +S +G+Y+C A+ R + Sbjct: 134 PQRLDVQLQFCFFRENQVLGSGWSSSPEL-QISAVWS---EDTGSYWCKAETVTHRIRKQ 189 Query: 554 VVSLFVTV---PVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS 610 + + V P+S L +R P Q G L L C G+ + + +Y E T S Sbjct: 190 SLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYRE-ATGTSM 248 Query: 611 SAPSGGEASFNLSLTA---EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPR 667 + S L + A +G Y C A+NG V S +++ V +PVSRP+LT R+P Sbjct: 249 GKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPG 308 Query: 668 AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSC 727 AQA VGDLLELHCEALRGS PILY FYHEDVTLG SAPSGGGASFNLSLT EHSG YSC Sbjct: 309 AQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSC 368 Query: 728 EADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFF 787 EA+NGL AQ SE V + ++ P + A G L G L+LY F Sbjct: 369 EANNGLGAQCSEAVPVSISGPDGYRRDLMTAGVLWGLFGVL------GFTGVALLLYALF 422 Query: 788 HEDVTLGNRSSPSGGAS 804 H+ + ++ GAS Sbjct: 423 HKISGESSATNEPRGAS 439 Score = 126 bits (316), Expect = 1e-28 Identities = 115/401 (28%), Positives = 184/401 (45%), Gaps = 37/401 (9%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L++ V+ Q + L P ++VF+G+ + L C+G + + QK ++ Sbjct: 1 MLLWSLLVIFDAVTEQ-----ADSLTLVAP-SSVFEGDSIVLKCQGEQNWKIQKMAYHKD 54 Query: 61 YLGKEILRETPDNILE---VQESGEYRCQAQG-----SPLSSPVHL---DFSSASLILQA 109 + ++ D +++ + +SG Y C +G S+ V + + ++ + Sbjct: 55 NKELSVFKKFSDFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTAS 114 Query: 110 PLSVFEGDSVVLRCRA-----KAEVTLNNTIYKNDNVL-AFLNKRTDFHIPHACLKDNGA 163 EG V L+C + +V L ++ + VL + + + I +D G+ Sbjct: 115 SFQPIEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGS 174 Query: 164 YRCTGYKES-CCPVSSNTVKIQVQE-PFTRPVL--RASSFQPISGNPVTLTCETQLSLER 219 Y C + S +I VQ P + L RA Q G + L C S+ Sbjct: 175 YWCKAETVTHRIRKQSLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLC----SVAG 230 Query: 220 SDVPLRFRFFRDDQTLGLG----WSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPR 275 + F ++R+ +G SLS +I A+ D+G Y+C+A + S Sbjct: 231 GTGNVTFSWYREATGTSMGKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVN 290 Query: 276 SWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRC 335 I V+IP S PVLTL A G + LHCE S LY+FYHE V L + S Sbjct: 291 --IPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPS 348 Query: 336 ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVP 376 GAS + SLT E+SGNY C A+NGLGA+ S+AV +S++ P Sbjct: 349 GGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGP 389 >gi|226958551 Fc receptor-like 1 isoform 3 precursor [Homo sapiens] Length = 428 Score = 242 bits (617), Expect = 1e-63 Identities = 169/418 (40%), Positives = 222/418 (53%), Gaps = 19/418 (4%) Query: 557 LFVTVPVSRPI-LTLRVPRAQAVVGDLLELHCEAP---RGSPPILYWFYHEDVTLGSSSA 612 L + P+ P L L + G + L C+ P + F+ + LG Sbjct: 7 LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP--- 63 Query: 613 PSGGEASFNLSLTA---EHSGNYSCEAN---NGLVAQHSDTISLSVIVPVSRPILTFRAP 666 G +S L + A E +G+Y CEA + ++ I++ VPV+ L + P Sbjct: 64 --GWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHR-VPVADVSLETQPP 120 Query: 667 RAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG-GASFNL-SLTTEHSGI 724 Q + GD L L C G+ I + +Y V L S A + + S+ + Sbjct: 121 GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180 Query: 725 YSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILY 784 Y C A+NG S +V++ V +PVSRP+L LRAP AAV D+LELHCEALRGSP ILY Sbjct: 181 YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY 240 Query: 785 RFFHEDVTLGNRSSPSGG-ASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTAN 843 F+HED+TLG+RS+PSGG AS NLSLT EHSGNYSCEA+NGLGAQRSE VTL T T Sbjct: 241 WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGA 300 Query: 844 RSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVP 903 RS +GV GLLS G A ALL L RK GR+ A DP RS QE TY N P Sbjct: 301 RSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSP 360 Query: 904 AWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVAS 961 +LQP+Y N N + VYS Q +++ + H+ +K S IYS ++ A+ Sbjct: 361 TPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAETLGTHMEDKVSLDIYSRLRKAN 418 Score = 211 bits (538), Expect = 2e-54 Identities = 122/280 (43%), Positives = 161/280 (57%), Gaps = 7/280 (2%) Query: 194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253 L AS P G+PVTLTC+ L+ SD +F FFRD + LG GWS SP QI AMW + Sbjct: 21 LIASPSHPTEGSPVTLTCKMPF-LQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKE 79 Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQV-QIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312 D+G YWC+A TM V+ S RS I V ++P + L P EG ++ L C Sbjct: 80 DTGSYWCEAQTMASKVLR-SRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAM 138 Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF---SLTTENSGNYYCTADNGLGAKPSKAV 369 + + +Y V L +S + +R + + S+ ++ YYC A+NG G PS V Sbjct: 139 GTGDITFLWYKGAVGLNLQS-KTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLV 197 Query: 370 SLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA 429 S++V +PVS P+L L +P + LHCEA RGS PILY F+HE L RSA S Sbjct: 198 SITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSG 257 Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVP 469 GG + + SLT EHSGNY C A+NG G QRS+AV+L+ TVP Sbjct: 258 GGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297 Score = 203 bits (516), Expect = 7e-52 Identities = 124/270 (45%), Positives = 161/270 (59%), Gaps = 9/270 (3%) Query: 393 EGAKVTLHCEA---QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCT 449 EG+ VTL C+ Q + F + AL +S+ + I+ ++ E +G+Y+C Sbjct: 30 EGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP-GWSSSPKLQIA-AMWKEDTGSYWCE 87 Query: 450 ADNGFGPQ-RSKAVSLSV-TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF 507 A RS+ ++V VPV+ L EG + L C V G+ I + + Sbjct: 88 AQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLW 147 Query: 508 YHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565 Y + L S + S+ S+ E + YYC A+NG+GP S +VS+ V +PVSR Sbjct: 148 YKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSR 207 Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLT 625 PIL LR PRAQA V D+LELHCEA RGSPPILYWFYHED+TLGS SAPSGG ASFNLSLT Sbjct: 208 PILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLT 267 Query: 626 AEHSGNYSCEANNGLVAQHSDTISLSVIVP 655 EHSGNYSCEANNGL AQ S+ ++L+ VP Sbjct: 268 EEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297 Score = 198 bits (503), Expect = 2e-50 Identities = 130/296 (43%), Positives = 168/296 (56%), Gaps = 16/296 (5%) Query: 464 LSVTVPVSHPV-LTLSSAEALTFEGATVTLHCEV---QRGSPQILYQFYHEDMPL---WS 516 L + P+ P L L ++ + EG+ VTL C++ Q Q + F+ + L WS Sbjct: 7 LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWS 66 Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ-RSEVVSLFV-TVPVSRPILTLRVPR 574 SS ++ + ++ + +G+Y+C A RS + V VPV+ L + P Sbjct: 67 SSP----KLQIA-AMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPG 121 Query: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGG-EASFNL-SLTAEHSGNY 632 Q + GD L L C G+ I + +Y V L S A + + S+ + Y Sbjct: 122 GQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQY 181 Query: 633 SCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692 C A NG S +S++V +PVSRPIL RAPRAQA V D+LELHCEALRGS PILYW Sbjct: 182 YCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYW 241 Query: 693 FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVP 748 FYHED+TLG SAPSGGGASFNLSLT EHSG YSCEA+NGL AQRSE VTL VP Sbjct: 242 FYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297 Score = 95.9 bits (237), Expect = 2e-19 Identities = 90/326 (27%), Positives = 140/326 (42%), Gaps = 35/326 (10%) Query: 90 SPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA----KAEVTLNNTIYKNDNVLA-F 144 +PL P L ++ +P EG V L C+ ++ +++ L Sbjct: 11 APLCEPAEL------FLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPG 64 Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV---LRASSFQP 201 + I +D G+Y C + + S +I V V + Q Sbjct: 65 WSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQV 124 Query: 202 ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW----SLSPNFQITAMWSKDSGF 257 + G+ + L C S+ + F +++ L L SL+ ++I ++ D+ Sbjct: 125 MEGDRLVLIC----SVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180 Query: 258 YWCKAAT----MPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQED 313 Y+C A P ++S I V+IP S P+L L +A + LHCE Sbjct: 181 YYCVAENGYGPSPSGLVS------ITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRG 234 Query: 314 SLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSV 373 S LY FYHE + L +S GAS + SLT E+SGNY C A+NGLGA+ S+AV+L+ Sbjct: 235 SPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNF 294 Query: 374 TVPVSHPVLNLSSPEDLIFEGAKVTL 399 TVP +L+S + EG TL Sbjct: 295 TVPTGARSNHLTSG---VIEGLLSTL 317 >gi|16418419 Fc receptor-like 1 isoform 1 precursor [Homo sapiens] Length = 429 Score = 240 bits (613), Expect = 4e-63 Identities = 170/420 (40%), Positives = 226/420 (53%), Gaps = 22/420 (5%) Query: 557 LFVTVPVSRPI-LTLRVPRAQAVVGDLLELHCEAP---RGSPPILYWFYHEDVTLGSSSA 612 L + P+ P L L + G + L C+ P + F+ + LG Sbjct: 7 LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP--- 63 Query: 613 PSGGEASFNLSLTA---EHSGNYSCEAN---NGLVAQHSDTISLSVIVPVSRPILTFRAP 666 G +S L + A E +G+Y CEA + ++ I++ VPV+ L + P Sbjct: 64 --GWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHR-VPVADVSLETQPP 120 Query: 667 RAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG-GASFNL-SLTTEHSGI 724 Q + GD L L C G+ I + +Y V L S A + + S+ + Sbjct: 121 GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180 Query: 725 YSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILY 784 Y C A+NG S +V++ V +PVSRP+L LRAP AAV D+LELHCEALRGSP ILY Sbjct: 181 YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY 240 Query: 785 RFFHEDVTLGNRSSPSGG-ASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTAN 843 F+HED+TLG+RS+PSGG AS NLSLT EHSGNYSCEA+NGLGAQRSE VTL T T Sbjct: 241 WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGA 300 Query: 844 RSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVP 903 RS +GV GLLS G A ALL L RK GR+ A DP RS QE TY N P Sbjct: 301 RSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSP 360 Query: 904 AWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDP--RHLRNKGSPIIYSEVKVAS 961 +LQP+Y N N + VYS + + ++ +VA++ H+ +K S IYS ++ A+ Sbjct: 361 TPGQLQPIYENVNVVSGDEVYS-LAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKAN 419 Score = 211 bits (538), Expect = 2e-54 Identities = 122/280 (43%), Positives = 161/280 (57%), Gaps = 7/280 (2%) Query: 194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253 L AS P G+PVTLTC+ L+ SD +F FFRD + LG GWS SP QI AMW + Sbjct: 21 LIASPSHPTEGSPVTLTCKMPF-LQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKE 79 Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQV-QIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312 D+G YWC+A TM V+ S RS I V ++P + L P EG ++ L C Sbjct: 80 DTGSYWCEAQTMASKVLR-SRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAM 138 Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF---SLTTENSGNYYCTADNGLGAKPSKAV 369 + + +Y V L +S + +R + + S+ ++ YYC A+NG G PS V Sbjct: 139 GTGDITFLWYKGAVGLNLQS-KTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLV 197 Query: 370 SLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA 429 S++V +PVS P+L L +P + LHCEA RGS PILY F+HE L RSA S Sbjct: 198 SITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSG 257 Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVP 469 GG + + SLT EHSGNY C A+NG G QRS+AV+L+ TVP Sbjct: 258 GGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297 Score = 203 bits (516), Expect = 7e-52 Identities = 124/270 (45%), Positives = 161/270 (59%), Gaps = 9/270 (3%) Query: 393 EGAKVTLHCEA---QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCT 449 EG+ VTL C+ Q + F + AL +S+ + I+ ++ E +G+Y+C Sbjct: 30 EGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP-GWSSSPKLQIA-AMWKEDTGSYWCE 87 Query: 450 ADNGFGPQ-RSKAVSLSV-TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF 507 A RS+ ++V VPV+ L EG + L C V G+ I + + Sbjct: 88 AQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLW 147 Query: 508 YHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565 Y + L S + S+ S+ E + YYC A+NG+GP S +VS+ V +PVSR Sbjct: 148 YKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSR 207 Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLT 625 PIL LR PRAQA V D+LELHCEA RGSPPILYWFYHED+TLGS SAPSGG ASFNLSLT Sbjct: 208 PILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLT 267 Query: 626 AEHSGNYSCEANNGLVAQHSDTISLSVIVP 655 EHSGNYSCEANNGL AQ S+ ++L+ VP Sbjct: 268 EEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297 Score = 198 bits (503), Expect = 2e-50 Identities = 130/296 (43%), Positives = 168/296 (56%), Gaps = 16/296 (5%) Query: 464 LSVTVPVSHPV-LTLSSAEALTFEGATVTLHCEV---QRGSPQILYQFYHEDMPL---WS 516 L + P+ P L L ++ + EG+ VTL C++ Q Q + F+ + L WS Sbjct: 7 LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWS 66 Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ-RSEVVSLFV-TVPVSRPILTLRVPR 574 SS ++ + ++ + +G+Y+C A RS + V VPV+ L + P Sbjct: 67 SSP----KLQIA-AMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPG 121 Query: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGG-EASFNL-SLTAEHSGNY 632 Q + GD L L C G+ I + +Y V L S A + + S+ + Y Sbjct: 122 GQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQY 181 Query: 633 SCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692 C A NG S +S++V +PVSRPIL RAPRAQA V D+LELHCEALRGS PILYW Sbjct: 182 YCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYW 241 Query: 693 FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVP 748 FYHED+TLG SAPSGGGASFNLSLT EHSG YSCEA+NGL AQRSE VTL VP Sbjct: 242 FYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVP 297 Score = 95.9 bits (237), Expect = 2e-19 Identities = 90/326 (27%), Positives = 140/326 (42%), Gaps = 35/326 (10%) Query: 90 SPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA----KAEVTLNNTIYKNDNVLA-F 144 +PL P L ++ +P EG V L C+ ++ +++ L Sbjct: 11 APLCEPAEL------FLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPG 64 Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV---LRASSFQP 201 + I +D G+Y C + + S +I V V + Q Sbjct: 65 WSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQV 124 Query: 202 ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW----SLSPNFQITAMWSKDSGF 257 + G+ + L C S+ + F +++ L L SL+ ++I ++ D+ Sbjct: 125 MEGDRLVLIC----SVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180 Query: 258 YWCKAAT----MPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQED 313 Y+C A P ++S I V+IP S P+L L +A + LHCE Sbjct: 181 YYCVAENGYGPSPSGLVS------ITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRG 234 Query: 314 SLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSV 373 S LY FYHE + L +S GAS + SLT E+SGNY C A+NGLGA+ S+AV+L+ Sbjct: 235 SPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNF 294 Query: 374 TVPVSHPVLNLSSPEDLIFEGAKVTL 399 TVP +L+S + EG TL Sbjct: 295 TVPTGARSNHLTSG---VIEGLLSTL 317 >gi|226958547 Fc receptor-like 1 isoform 2 precursor [Homo sapiens] Length = 366 Score = 207 bits (527), Expect = 4e-53 Identities = 120/278 (43%), Positives = 159/278 (57%), Gaps = 7/278 (2%) Query: 194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253 L AS P G+PVTLTC+ L+ SD +F FFRD + LG GWS SP QI AMW + Sbjct: 21 LIASPSHPTEGSPVTLTCKMPF-LQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKE 79 Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQV-QIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312 D+G YWC+A TM V+ S RS I V ++P + L P EG ++ L C Sbjct: 80 DTGSYWCEAQTMASKVLR-SRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAM 138 Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF---SLTTENSGNYYCTADNGLGAKPSKAV 369 + + +Y V L +S + +R + + S+ ++ YYC A+NG G PS V Sbjct: 139 GTGDITFLWYKGAVGLNLQS-KTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLV 197 Query: 370 SLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA 429 S++V +PVS P+L L +P + LHCEA RGS PILY F+HE L RSA S Sbjct: 198 SITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSG 257 Query: 430 GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVT 467 GG + + SLT EHSGNY C A+NG G QRS+AV+L+ T Sbjct: 258 GGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFT 295 Score = 199 bits (507), Expect = 8e-51 Identities = 122/266 (45%), Positives = 159/266 (59%), Gaps = 9/266 (3%) Query: 393 EGAKVTLHCEA---QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCT 449 EG+ VTL C+ Q + F + AL +S+ + I+ ++ E +G+Y+C Sbjct: 30 EGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP-GWSSSPKLQIA-AMWKEDTGSYWCE 87 Query: 450 ADNGFGPQ-RSKAVSLSV-TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQF 507 A RS+ ++V VPV+ L EG + L C V G+ I + + Sbjct: 88 AQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLW 147 Query: 508 YHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565 Y + L S + S+ S+ E + YYC A+NG+GP S +VS+ V +PVSR Sbjct: 148 YKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSR 207 Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLT 625 PIL LR PRAQA V D+LELHCEA RGSPPILYWFYHED+TLGS SAPSGG ASFNLSLT Sbjct: 208 PILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLT 267 Query: 626 AEHSGNYSCEANNGLVAQHSDTISLS 651 EHSGNYSCEANNGL AQ S+ ++L+ Sbjct: 268 EEHSGNYSCEANNGLGAQRSEAVTLN 293 Score = 194 bits (493), Expect = 3e-49 Identities = 128/291 (43%), Positives = 166/291 (57%), Gaps = 16/291 (5%) Query: 464 LSVTVPVSHPV-LTLSSAEALTFEGATVTLHCEV---QRGSPQILYQFYHEDMPL---WS 516 L + P+ P L L ++ + EG+ VTL C++ Q Q + F+ + L WS Sbjct: 7 LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWS 66 Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ-RSEVVSLFV-TVPVSRPILTLRVPR 574 SS ++ + ++ + +G+Y+C A RS + V VPV+ L + P Sbjct: 67 SSP----KLQIA-AMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPG 121 Query: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGG-EASFNL-SLTAEHSGNY 632 Q + GD L L C G+ I + +Y V L S A + + S+ + Y Sbjct: 122 GQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQY 181 Query: 633 SCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692 C A NG S +S++V +PVSRPIL RAPRAQA V D+LELHCEALRGS PILYW Sbjct: 182 YCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYW 241 Query: 693 FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTL 743 FYHED+TLG SAPSGGGASFNLSLT EHSG YSCEA+NGL AQRSE VTL Sbjct: 242 FYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTL 292 Score = 191 bits (486), Expect = 2e-48 Identities = 143/379 (37%), Positives = 187/379 (49%), Gaps = 59/379 (15%) Query: 557 LFVTVPVSRPI-LTLRVPRAQAVVGDLLELHCEAP---RGSPPILYWFYHEDVTLGSSSA 612 L + P+ P L L + G + L C+ P + F+ + LG Sbjct: 7 LLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGP--- 63 Query: 613 PSGGEASFNLSLTA---EHSGNYSCEAN---NGLVAQHSDTISLSVIVPVSRPILTFRAP 666 G +S L + A E +G+Y CEA + ++ I++ VPV+ L + P Sbjct: 64 --GWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHR-VPVADVSLETQPP 120 Query: 667 RAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG-GASFNL-SLTTEHSGI 724 Q + GD L L C G+ I + +Y V L S A + + S+ + Sbjct: 121 GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ 180 Query: 725 YSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILY 784 Y C A+NG S +V++ V +PVSRP+L LRAP AAV D+LELHCEALRGSP ILY Sbjct: 181 YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY 240 Query: 785 RFFHEDVTLGNRSSPS-GGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTAN 843 F+HED+TLG+RS+PS GGAS NLSLT EHSGNYSCEA+NGLGAQRSE VTL T Sbjct: 241 WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFT----- 295 Query: 844 RSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVP 903 GR+ A DP RS QE TY N P Sbjct: 296 ----------------------------------GRRSARDPLRSLPSPLPQEFTYLNSP 321 Query: 904 AWEELQPVYTNANPRGENV 922 +LQP+Y N PR ++V Sbjct: 322 TPGQLQPIYEN-EPREQSV 339 Score = 148 bits (373), Expect = 3e-35 Identities = 105/306 (34%), Positives = 149/306 (48%), Gaps = 32/306 (10%) Query: 274 PRSWIQVQIPASHPV-LTLSPEKALNFEGTKVTLHCET---QEDSLRTLYRFYHEGVPLR 329 PR + + P P L L + EG+ VTL C+ Q + + F+ + L Sbjct: 3 PRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALG 62 Query: 330 ---HKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTV---PVSHPVLN 383 S + + A + E++G+Y+C A + +K ++ + V PV+ L Sbjct: 63 PGWSSSPKLQIAA-----MWKEDTGSYWCEAQT-MASKVLRSRRSQINVHRVPVADVSLE 116 Query: 384 LSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEH- 442 P + EG ++ L C G+ I + ++ L +S SLTAE+ Sbjct: 117 TQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQR-------SLTAEYE 169 Query: 443 --------SGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHC 494 + YYC A+NG+GP S VS++V +PVS P+L L + A + LHC Sbjct: 170 IPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHC 229 Query: 495 EVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV 554 E RGSP ILY FYHED+ L S S PS G SF+ SLTE HSGNY C A+NG G QRSE Sbjct: 230 EALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEA 289 Query: 555 VSLFVT 560 V+L T Sbjct: 290 VTLNFT 295 >gi|50878302 Fc receptor-like B [Homo sapiens] Length = 426 Score = 166 bits (419), Expect = 1e-40 Identities = 108/301 (35%), Positives = 158/301 (52%), Gaps = 21/301 (6%) Query: 7 LLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFR----FYSPQKTKWYHRYL 62 LL+L P SGQ A +PI+ L PPWTT+F+GERVTL C G+ P T W YL Sbjct: 7 LLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLW---YL 63 Query: 63 GKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS-VFEGDSVVL 121 G +L + +EVQ G YRCQ +G+P+S P+HL S+ LILQ P + VFEG+ +VL Sbjct: 64 G-HLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVL 122 Query: 122 RCRAKAEVTLNNTIYKND-NVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE---SCCPVS 177 RCR + + Y +D + + + ++ + A D+G Y+C+G P+ Sbjct: 123 RCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAPMF 182 Query: 178 SNTVKIQVQEPFTRPVLRASSFQPISG---NPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 S V + VQE F PVLR + G V L C+T+L ++ D PL+F F++ + Sbjct: 183 SAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRA 242 Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPAS--HPVLTLS 292 + + + + ++ YWC+AAT SV SP W+Q+ P S P T + Sbjct: 243 V-RRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSP--WLQLPGPGSPLDPASTTA 299 Query: 293 P 293 P Sbjct: 300 P 300 Score = 49.7 bits (117), Expect = 1e-05 Identities = 59/237 (24%), Positives = 90/237 (37%), Gaps = 37/237 (15%) Query: 287 PVLTLSPEKALNFEGTKVTLHCE------TQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340 P+L+L P F+G +VTL C+ + + TL+ H +P KS+ Sbjct: 23 PILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKKSIE------ 76 Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400 + G Y C GA S + LSV S+ L L P +FEG + L Sbjct: 77 ------VQTPGVYRCQTR---GAPVSDPIHLSV----SNDWLILQVPYAPVFEGEPLVLR 123 Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460 C + ++H+G A+ R +S+ + A SG Y C+ + + Sbjct: 124 CRGWYDKVVYKLHYYHDGQAV--RYFHSSANYTV-LQARASDSGRYQCSGTMRIPVESAP 180 Query: 461 AVSLSVTVPVSH----PVL-TLSSAEALTFEGATVTLHCEV----QRGSPQILYQFY 508 S V V V PVL + EA V L C+ Q+ + + FY Sbjct: 181 MFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFY 237 Score = 43.1 bits (100), Expect = 0.001 Identities = 77/320 (24%), Positives = 115/320 (35%), Gaps = 56/320 (17%) Query: 563 VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY--------WFYHEDVTLGSSSAPS 614 + +PIL+L P G+ + L C+ G P+L W+ LG PS Sbjct: 20 LEKPILSLHPPWTTIFKGERVTLKCD---GYHPLLLELQPISTLWY------LGHLLLPS 70 Query: 615 GGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD 674 + S+ + G Y C+ V SD I LSV S L + P A G+ Sbjct: 71 HKK-----SIEVQTPGVYRCQTRGAPV---SDPIHLSV----SNDWLILQVPYAPVFEGE 118 Query: 675 LLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFN-LSLTTEHSGIYSCEADNGL 733 L L C +YH+ G+ A++ L SG Y C + Sbjct: 119 PLVLRCRGWYDKVVYKLHYYHD----GQAVRYFHSSANYTVLQARASDSGRYQCSGTMRI 174 Query: 734 EAQRSEMVTLKVAVPVSR----PVLTLRAP--GTHAAVGDLLELHCEA-----LRGSPLI 782 + + M + KVAV V PVL + P AA+G ++ L C+ R +PL Sbjct: 175 PVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVV-LRCDTRLHPQKRDTPL- 232 Query: 783 LYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITG--- 839 +F + R G E +Y CEA + R + L + G Sbjct: 233 --QFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGS 290 Query: 840 ----LTANRSGPFATGVAGG 855 + P+A +A G Sbjct: 291 PLDPASTTAPAPWAAALAPG 310 Score = 40.8 bits (94), Expect = 0.006 Identities = 55/235 (23%), Positives = 88/235 (37%), Gaps = 41/235 (17%) Query: 204 GNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAA 263 G VTL C+ L P+ ++ LG L P+ + ++ + G Y C+ Sbjct: 37 GERVTLKCDGYHPLLLELQPISTLWY-------LGHLLLPSHK-KSIEVQTPGVYRCQTR 88 Query: 264 TMPYS--VISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRF 321 P S + W+ +Q+P + PV FEG + L C D + + Sbjct: 89 GAPVSDPIHLSVSNDWLILQVPYA-PV----------FEGEPLVLRCRGWYDKVVYKLHY 137 Query: 322 YHEGVPLR--HKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH 379 YH+G +R H S +SG Y C+ + + + S V V V Sbjct: 138 YHDGQAVRYFHSSAN-----YTVLQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQE 192 Query: 380 ----PVLNLSSPEDLIFEGAK---VTLHCEA----QRGSLPILYQFHHEGAALER 423 PVL + P + GA V L C+ Q+ P+ + F+ A+ R Sbjct: 193 LFRAPVLRVMGPREA--RGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRR 245 Score = 37.7 bits (86), Expect = 0.053 Identities = 58/241 (24%), Positives = 91/241 (37%), Gaps = 45/241 (18%) Query: 380 PVLNLSSPEDLIFEGAKVTLHCEAQRGSL----PI--LYQFHHEGAALERRSANSAGGVA 433 P+L+L P IF+G +VTL C+ L PI L+ H ++ Sbjct: 23 PILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKK--------- 73 Query: 434 ISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLH 493 S+ + G Y C R VS + + VS+ L L A FEG + L Sbjct: 74 ---SIEVQTPGVYRCQT-------RGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVLR 123 Query: 494 CEVQRGSPQILYQFYHEDMPL---WSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ 550 C +YH+ + SS+ +V + S SG Y C+ + Sbjct: 124 CRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARAS------DSGRYQCSGTMRIPVE 177 Query: 551 RSEVVSLFVTVPVSR----PILTLRVPRAQ--AVVGDLLELHCEA----PRGSPPILYWF 600 + + S V V V P+L + PR A +G ++ L C+ + P+ + F Sbjct: 178 SAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVV-LRCDTRLHPQKRDTPLQFAF 236 Query: 601 Y 601 Y Sbjct: 237 Y 237 >gi|10835133 Fc fragment of IgG, high affinity Ia, receptor (CD64) [Homo sapiens] Length = 374 Score = 157 bits (397), Expect = 5e-38 Identities = 105/286 (36%), Positives = 147/286 (51%), Gaps = 14/286 (4%) Query: 3 LWVI--LLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 +W + LL+ PV GQ T + +I LQPPW +VFQ E VTL C+ T+W+ Sbjct: 1 MWFLTTLLLWVPVDGQ-VDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLN 59 Query: 61 YLGKEILRETPD---NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF-EG 116 G TP V +SGEYRCQ S S P+ L+ L+LQ VF EG Sbjct: 60 --GTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEG 117 Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175 + + LRC A K ++ N Y+N F + ++ I + NG Y C+G + Sbjct: 118 EPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKH--R 175 Query: 176 VSSNTVKIQVQEPFTRPVLRASSFQP-ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 +S + + V+E F PVL AS P + GN VTL+CET+L L+R + L F F+ +T Sbjct: 176 YTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKT 235 Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQV 280 L G + S +QI +DSG YWC+AAT +V+ SP +QV Sbjct: 236 L-RGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQV 280 Score = 64.7 bits (156), Expect = 4e-10 Identities = 69/274 (25%), Positives = 109/274 (39%), Gaps = 28/274 (10%) Query: 277 WIQV--QIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVR 334 W+ V Q+ + V+TL P F+ VTLHCE + +++ G + + Sbjct: 10 WVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGT-----ATQ 64 Query: 335 CERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEG 394 + S + +SG Y C GL + S + + + L L + EG Sbjct: 65 TSTPSYRITSASVNDSGEYRC--QRGLSGR-----SDPIQLEIHRGWLLLQVSSRVFTEG 117 Query: 395 AKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGF 454 + L C A + L ++ G A + NS + H+G Y+C +G Sbjct: 118 EPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTI---LKTNISHNGTYHC---SGM 171 Query: 455 GPQRSKAVSLSVTVPVSHPVLTL-SSAEALTFEGATVTLHCE----VQRGSPQILYQFYH 509 G R + +SVTV P L +S + EG VTL CE +QR Q+ + FY Sbjct: 172 GKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYM 231 Query: 510 EDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTA 543 L +T S ++ + SG Y+C A Sbjct: 232 GSKTLRGRNTSSEYQI---LTARREDSGLYWCEA 262 Score = 46.2 bits (108), Expect = 1e-04 Identities = 85/326 (26%), Positives = 124/326 (38%), Gaps = 57/326 (17%) Query: 468 VPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSF 527 V + V+TL F+ TVTLHCEV Q++ +STPS S Sbjct: 17 VDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTAT-QTSTPSYRITSA 75 Query: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587 S + SG Y C G RS+ + L + R L L+V G+ L L C Sbjct: 76 SVN----DSGEYRC--QRGLS-GRSDPIQL----EIHRGWLLLQVSSRVFTEGEPLALRC 124 Query: 588 EAPRGS--PPILYW-------FYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANN 638 A + +LY+ F+H + L L H+G Y C + Sbjct: 125 HAWKDKLVYNVLYYRNGKAFKFFHWNSNLTI------------LKTNISHNGTYHC---S 169 Query: 639 GLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVV-GDLLELHCEA----LRGSSPILYWF 693 G+ + +SV V P A ++ G+L+ L CE R + + F Sbjct: 170 GMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSF 229 Query: 694 YHEDVTLGKISAPSGGGASFNLSLTT---EHSGIYSCEA--DNGLEAQRS-----EMVTL 743 Y TL G S + T E SG+Y CEA ++G +RS +++ L Sbjct: 230 YMGSKTL------RGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGL 283 Query: 744 KVAVPVSRPVLTLRAPGTHAAVGDLL 769 ++ PV VL A G V +L Sbjct: 284 QLPTPVWFHVLFYLAVGIMFLVNTVL 309 >gi|157057547 Fc receptor-like 6 [Homo sapiens] Length = 434 Score = 133 bits (335), Expect = 7e-31 Identities = 129/408 (31%), Positives = 187/408 (45%), Gaps = 45/408 (11%) Query: 580 GDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNG 639 GD L L C+ + +P FY + L S + + T + G YSC Sbjct: 32 GDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKE---NQTLSMGAATVQSRGQYSCSGQVM 88 Query: 640 LVAQHSDTISLSVIVPVSR----PILTFRAPRAQAVVGDLLELHCEA----LRGSSPILY 691 + Q S + +V V P+L+ P + G L+ L C+ LR + +L+ Sbjct: 89 YIPQTFTQTSETAMVQVQELFPPPVLS-AIPSPEPREGSLVTLRCQTKLHPLRSALRLLF 147 Query: 692 WFYHEDVTLGKISAPSGGGASFNLSLTTE-HSGIYSCEA--DNGLEAQRSEMVTLKVAVP 748 F+ + TL G + E SG+Y CE + G ++S + ++V P Sbjct: 148 SFHKDGHTL----QDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAP 203 Query: 749 VSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGG-ASLNL 807 VSRPVLTL AVGD+++L CEA RGSP ILY F+ ++ +GN S+P GG SL Sbjct: 204 VSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLF 263 Query: 808 SLTAEH-SGNYSCEADNGLGAQRSETVTLYITG---LTANRSGPFATGVAGGLLSIAGLA 863 + +E +GNYSCEA+N + +RSE L + G L S + LL + +A Sbjct: 264 PVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIA 323 Query: 864 AGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVV 923 A ALL+Y RKAG P+ P +P Q P Y NV + + E VV Sbjct: 324 A-ALLVYVRSWRKAGPLPSQIPPTAP--GGEQCPLYANV----------HHQKGKDEGVV 370 Query: 924 YSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVK------VASTPVS 965 YS V + K+ S + K S II +EV+ V+ST V+ Sbjct: 371 YSVVH--RTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVN 416 Score = 131 bits (330), Expect = 3e-30 Identities = 98/276 (35%), Positives = 134/276 (48%), Gaps = 8/276 (2%) Query: 105 LILQA-PLSVFEGDSVVLRCRAKAEVTLNNT-IYKNDNVLAFLNKRTDFHIPHACLKDNG 162 L LQA P VFEGD++ LRC+ L+ Y++ L F + + A ++ G Sbjct: 20 LYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRG 79 Query: 163 AYRCTG---YKESCCPVSSNTVKIQVQEPFTRPVLRA-SSFQPISGNPVTLTCETQLSLE 218 Y C+G Y +S T +QVQE F PVL A S +P G+ VTL C+T+L Sbjct: 80 QYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPL 139 Query: 219 RSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWI 278 RS + L F F +D TL P I DSG YWC+ A V SP+ + Sbjct: 140 RSALRLLFSFHKDGHTLQ-DRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEV 198 Query: 279 QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERG 338 +VQ P S PVLTL A G V L CE Q S LY FY + + + S C Sbjct: 199 RVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGT 258 Query: 339 ASISFSLTTE-NSGNYYCTADNGLGAKPSKAVSLSV 373 S+ F + +E ++GNY C A+N + + S+ LS+ Sbjct: 259 TSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSL 294 Score = 120 bits (301), Expect = 6e-27 Identities = 88/274 (32%), Positives = 135/274 (49%), Gaps = 20/274 (7%) Query: 391 IFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTA 450 +FEG +TL C+ + + +F+ +G L N + + T + G Y C+ Sbjct: 29 VFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAA---TVQSRGQYSCSG 85 Query: 451 DNGFGPQRSKAVSLSVTVPVSH----PVLT-LSSAEALTFEGATVTLHCEVQ----RGSP 501 + PQ S + V V PVL+ + S E EG+ VTL C+ + R + Sbjct: 86 QVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPR--EGSLVTLRCQTKLHPLRSAL 143 Query: 502 QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTA--DNGFGPQRSEVVSLFV 559 ++L+ F+ + L + EG SG Y+C + G ++S + + V Sbjct: 144 RLLFSFHKDGHTLQDRGPHPELCIP---GAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRV 200 Query: 560 TVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEAS 619 PVSRP+LTL A VGD+++L CEA RGSPPILY FY ++ +G+ SAP GG S Sbjct: 201 QAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTS 260 Query: 620 FNLSLTAEH-SGNYSCEANNGLVAQHSDTISLSV 652 + +E +GNYSCEA N + + S+ LS+ Sbjct: 261 LLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSL 294 Score = 97.1 bits (240), Expect = 7e-20 Identities = 86/280 (30%), Positives = 125/280 (44%), Gaps = 34/280 (12%) Query: 204 GNPVTLTCETQLSLERSDVPLR-----FRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFY 258 G+ +TL C+ + S V F +++QTL +G A + G Y Sbjct: 32 GDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMG----------AATVQSRGQY 81 Query: 259 WCKAATM--PYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQ----E 312 C M P + S + +QVQ PVL+ P EG+ VTL C+T+ Sbjct: 82 SCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPR-EGSLVTLRCQTKLHPLR 140 Query: 313 DSLRTLYRFYHEGVPLRHKSVR---CERGASISFSLTTENSGNYYCTA--DNGLGAKPSK 367 +LR L+ F+ +G L+ + C GA +SG Y+C + G K S Sbjct: 141 SALRLLFSFHKDGHTLQDRGPHPELCIPGAKEG------DSGLYWCEVAPEGGQVQKQSP 194 Query: 368 AVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSAN 427 + + V PVS PVL L G V L CEAQRGS PILY F+ + + SA Sbjct: 195 QLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAP 254 Query: 428 SAGGVAISFSLTAEH-SGNYYCTADNGFGPQRSKAVSLSV 466 G ++ F + +E +GNY C A+N +RS+ LS+ Sbjct: 255 CGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSL 294 Score = 70.1 bits (170), Expect = 1e-11 Identities = 78/293 (26%), Positives = 126/293 (43%), Gaps = 46/293 (15%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L+ P G+ ++LQ VF+G+ +TL C+G++ + K+Y Sbjct: 1 MLLWTAVLLFVPCVGKTVW-----LYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRD 55 Query: 61 YLGKEILRETPDNILE-----VQESGEYRCQAQGSPLSSPVHLDFSSASLILQA----PL 111 GK + + L VQ G+Y C G + P +S + ++Q P Sbjct: 56 --GKFLHFSKENQTLSMGAATVQSRGQYSC--SGQVMYIPQTFTQTSETAMVQVQELFPP 111 Query: 112 SVF---------EGDSVVLRCRAK-----AEVTLNNTIYKNDNVLAFLNKRTDFHIPHAC 157 V EG V LRC+ K + + L + +K+ + L + IP A Sbjct: 112 PVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAK 171 Query: 158 LKDNGAYRCTGYKE-SCCPVSSNTVKIQVQEPFTRPV--LRASSFQPISGNPVTLTCETQ 214 D+G Y C E S ++++VQ P +RPV L P G+ V L CE Q Sbjct: 172 EGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQ 231 Query: 215 LSLERSDVPLRFRFFRDDQTLG-----LGWSLSPNFQITAMWSKDSGFYWCKA 262 R P+ + F+ D++ +G G + S F + + +D+G Y C+A Sbjct: 232 ----RGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKS--EQDAGNYSCEA 278 >gi|69885149 Fc receptor-like and mucin-like 1 [Homo sapiens] Length = 376 Score = 124 bits (310), Expect = 6e-28 Identities = 88/236 (37%), Positives = 127/236 (53%), Gaps = 13/236 (5%) Query: 70 TPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS-VFEGDSVVLRCRAKAE 128 T D++ + +E+G Q + S P HL S LILQ P VFEGD +VLRC+A + Sbjct: 65 TEDDLTDAREAG---FQVKAYTFSEPFHLIVSYDWLILQGPAKPVFEGDLLVLRCQAWQD 121 Query: 129 VTLNN-TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESC---CPVSSNTVKIQ 184 L T Y++ + L +F I D+G Y C+G +S P +++ V I Sbjct: 122 WPLTQVTFYRDGSALGPPGPNREFSITVVQKADSGHYHCSGIFQSPGPGIPETASVVAIT 181 Query: 185 VQEPFTRPVLRA-SSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSP 243 VQE F P+LRA S +P +G+P+TL+C+T+L L+RS L F F++D + + LS Sbjct: 182 VQELFPAPILRAVPSAEPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIV-QSRGLSS 240 Query: 244 NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQ---IPASHPVLTLSPEKA 296 FQI SG YWC+AAT V SP+ I+VQ A+ P L +P+K+ Sbjct: 241 EFQIPTASEDHSGSYWCEAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKS 296 Score = 57.8 bits (138), Expect = 5e-08 Identities = 63/232 (27%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 377 VSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISF 436 VS+ L L P +FEG + L C+A + F+ +G+AL N + + Sbjct: 92 VSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALGPPGPNREFSITV-- 149 Query: 437 SLTAEHSGNYYCTA---DNGFG-PQRSKAVSLSVTVPVSHPVL-TLSSAEALTFEGATVT 491 + SG+Y+C+ G G P+ + V+++V P+L + SAE G+ +T Sbjct: 150 -VQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQA--GSPMT 206 Query: 492 LHCE----VQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYC---TAD 544 L C+ +QR + ++L+ FY + + S S ++ + +E HSG+Y+C T D Sbjct: 207 LSCQTKLPLQRSAARLLFSFYKDGRIVQSRGLSSEFQIP---TASEDHSGSYWCEAATED 263 Query: 545 NGFGPQRSEVVSLFVTVPVSRPILTLR-VPRAQAVVGDLLELHCEAPRGSPP 595 N Q ++ S TL P+ A G E EAP PP Sbjct: 264 NQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPGTAPE---EAPGPLPP 312 Score = 56.6 bits (135), Expect = 1e-07 Identities = 59/218 (27%), Positives = 98/218 (44%), Gaps = 23/218 (10%) Query: 563 VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL 622 VS L L+ P GDLL L C+A + P FY + GS+ P G F++ Sbjct: 92 VSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRD----GSALGPPGPNREFSI 147 Query: 623 SLTAE-HSGNYSC----EANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLE 677 ++ + SG+Y C ++ + + + ++++V PIL P A+ G + Sbjct: 148 TVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILR-AVPSAEPQAGSPMT 206 Query: 678 LHCEA----LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE-HSGIYSCEA--- 729 L C+ R ++ +L+ FY + G+I G + F + +E HSG Y CEA Sbjct: 207 LSCQTKLPLQRSAARLLFSFYKD----GRIVQSRGLSSEFQIPTASEDHSGSYWCEAATE 262 Query: 730 DNGLEAQRSEM-VTLKVAVPVSRPVLTLRAPGTHAAVG 766 DN + Q ++ + ++ A + P AP AA G Sbjct: 263 DNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPG 300 Score = 54.7 bits (130), Expect = 4e-07 Identities = 63/232 (27%), Positives = 99/232 (42%), Gaps = 41/232 (17%) Query: 277 WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCE 336 W+ +Q PA PV FEG + L C+ +D T FY +G S Sbjct: 96 WLILQGPAK-PV----------FEGDLLVLRCQAWQDWPLTQVTFYRDG------SALGP 138 Query: 337 RGASISFSLTT---ENSGNYYCTA---DNGLGAKPSKAVSLSVTVPVSHPVLNLSS-PED 389 G + FS+T +SG+Y+C+ G G P A +++TV P L + P Sbjct: 139 PGPNREFSITVVQKADSGHYHCSGIFQSPGPGI-PETASVVAITVQELFPAPILRAVPSA 197 Query: 390 LIFEGAKVTLHCEA----QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGN 445 G+ +TL C+ QR + +L+ F+ +G ++ R +S + + + +HSG+ Sbjct: 198 EPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIVQSRGLSSEFQIP---TASEDHSGS 254 Query: 446 YYC---TADNGFGPQ------RSKAVSLSVTVPVSHPVLTLSSAEALTFEGA 488 Y+C T DN Q R + S S P +P S+A E A Sbjct: 255 YWCEAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPGTAPEEA 306 Score = 43.9 bits (102), Expect = 7e-04 Identities = 53/206 (25%), Positives = 82/206 (39%), Gaps = 24/206 (11%) Query: 656 VSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNL 715 VS L + P GDLL L C+A + FY + LG P G F++ Sbjct: 92 VSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALG----PPGPNREFSI 147 Query: 716 SLTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSR--PVLTLRA-PGTHAAVGDLLEL 771 ++ + SG Y C VA+ V P LRA P G + L Sbjct: 148 TVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQAGSPMTL 207 Query: 772 HCEAL----RGSPLILYRFFHEDVTLGNRSSPSGGASLNLSL---TAEHSGNYSCEA--- 821 C+ R + +L+ F+ + R S G S + + +HSG+Y CEA Sbjct: 208 SCQTKLPLQRSAARLLFSFYKD-----GRIVQSRGLSSEFQIPTASEDHSGSYWCEAATE 262 Query: 822 DNGLGAQRSETVTLYITGLTANRSGP 847 DN + Q S + + + G +++ + P Sbjct: 263 DNQVWKQ-SPQLEIRVQGASSSAAPP 287 Score = 36.2 bits (82), Expect = 0.15 Identities = 36/166 (21%), Positives = 67/166 (40%), Gaps = 19/166 (11%) Query: 25 IFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKE-ILRETPDNILEVQESG 81 + LQ P VF+G+ + L C+ ++ + + +Y LG RE +++ +SG Sbjct: 97 LILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALGPPGPNREFSITVVQKADSG 156 Query: 82 EYRC----QAQGSPLSSPVHLDFSSASLILQAPL-------SVFEGDSVVLRCRAK---- 126 Y C Q+ G + + + + AP+ G + L C+ K Sbjct: 157 HYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQAGSPMTLSCQTKLPLQ 216 Query: 127 -AEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171 + L + YK+ ++ ++F IP A +G+Y C E Sbjct: 217 RSAARLLFSFYKDGRIVQSRGLSSEFQIPTASEDHSGSYWCEAATE 262 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 113 bits (282), Expect = 1e-24 Identities = 192/811 (23%), Positives = 304/811 (37%), Gaps = 100/811 (12%) Query: 76 EVQESGEYRCQAQ--GSPLSSPVHLDFSSASLILQ--APLSVFEGDSVVLRCRAKAEVTL 131 E +G+Y CQ + G + L ++I++ P++V G++ L C+ L Sbjct: 5674 EPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPEL 5733 Query: 132 NNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRC---TGYKESCCPVSSNT 180 + YK+ +L +F NK + I +D G Y +S C + Sbjct: 5734 SVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDV 5793 Query: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240 V FTR R + + G L C+ S P+ +F + + G Sbjct: 5794 SDRAVPPSFTR---RLKNTGGVLGASCILECKVAGSS-----PISVAWFHEKTKIVSGAK 5845 Query: 241 LSPNF-------QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293 F Q+ ++ S D G Y C AA + S D R+ + VQ P P P Sbjct: 5846 YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGS---DECRAVLTVQEP---PSFVKEP 5899 Query: 294 EKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRC-----ERGASIS-FSLTT 347 E G VT + + F G K RC + A + F++ Sbjct: 5900 EPLEVLPGKNVTFTSVIRGTPPFKVNWF--RGARELVKGDRCNIYFEDTVAELELFNIDI 5957 Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 SG Y C N G S + + V P L D E K + G+ Sbjct: 5958 SQSGEYTCVVSNNAGQ-----ASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGT 6012 Query: 408 LPILYQFHHEGAAL---ERRSANSAGGVAISFSL--TAEHSGNYYCTADNGFGPQRSKAV 462 LPI + +G + E+ + + I L T +G Y C +N G R Sbjct: 6013 LPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG--RDVCG 6070 Query: 463 SLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS---- 518 +L T+ + V L EA G +V+L C+V G+P+I +Y D L + Sbjct: 6071 ALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVA-GTPEITVSWYKGDTKLRPTPEYRT 6127 Query: 519 --TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQ 576 T +V + F+ + SG Y C A+N G S+ V + P ++ + Sbjct: 6128 YFTNNVATLVFN-KVNINDSGEYTCKAENSIGTASSKTVFRIQERQLP-PSFARQLKDIE 6185 Query: 577 AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGS-----SSAPSGGEASFNLSLTAEHSGN 631 VG + L C GS PI +Y + V L +S L HSG Sbjct: 6186 QTVGLPVTLTCRL-NGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQ 6244 Query: 632 YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILY 691 YSC A+N L S + L+ P P + + G+ + C + G+ P+ Sbjct: 6245 YSCSASNPL-GTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECH-VTGAQPMRI 6302 Query: 692 WFYHEDVTLGKISAPSGGGASFNLSLTTEH----------SGIYSCEADNGLEAQRSEMV 741 + ++ + GG + T H SG Y+C+A N + +M Sbjct: 6303 TWSKDNKEIRP-----GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVG---KDMC 6354 Query: 742 TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLG-----NR 796 + +++V + A G+ ++L C+ + GSP I +F D L N Sbjct: 6355 SAQLSVKEPPKFVKKLEASKVAKQGESIQLECK-ISGSPEIKVSWFRNDSELHESWKYNM 6413 Query: 797 SSPSGGASLNLS-LTAEHSGNYSCEADNGLG 826 S + A L ++ +AE SG+Y CEA NG+G Sbjct: 6414 SFINSVALLTINEASAEDSGDYICEAHNGVG 6444 Score = 112 bits (280), Expect = 2e-24 Identities = 201/827 (24%), Positives = 308/827 (37%), Gaps = 117/827 (14%) Query: 75 LEVQESGEYRCQAQGSPLSSPVHLDFSSASLIL---------QAPLSVFEGDSVVLRCRA 125 L +Q+ G Y C+A S+ D A LI+ P+ V L C+ Sbjct: 3613 LTIQDRGVYSCKA-----SNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQV 3667 Query: 126 KAEVTLNNTIYKN--------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVS 177 + + T K+ D + F +K IP A LKD+G Y CT E+ Sbjct: 3668 DEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSC 3727 Query: 178 SNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGL 237 S TV ++ F + V S+ + G L C+ L+ S V ++ +F++++ L Sbjct: 3728 SATVTVREPPSFVKKV--DPSYLMLPGESARLHCK----LKGSPV-IQVTWFKNNKELSE 3780 Query: 238 GWSLSPNF-------QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290 ++ F IT + +DSG Y C+A V SDS + I ++ P S + T Sbjct: 3781 SNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVN---DVGSDSCSTEIVIKEPPSF-IKT 3836 Query: 291 LSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASI----SFSLT 346 L P + GT L CE + F + K R S+ FS Sbjct: 3837 LEPADIV--RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFN 3894 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406 + + G Y C N +G A L + P + +DLI G + A RG Sbjct: 3895 SADVGEYECVVANEVGKCGCMATHL-----LKEPPTFVKKVDDLIALGGQTVTLQAAVRG 3949 Query: 407 SLPILYQFHHEGAALE-----RRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKA 461 S PI + + + S ++ V I + G Y C A+N G Q S Sbjct: 3950 SEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVG 4009 Query: 462 VSLSVTVPVSHPVLTLSSAEAL-TFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTP 520 + V P + AE + G TL V G+P++ ++Y + PL +S Sbjct: 4010 ELI-----VKEPAKIIERAELIQVTAGDPATLEYTV-AGTPELKPKWYKDGRPLVASKK- 4062 Query: 521 SVGRVSF-------SFSLTEGH-SGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572 R+SF F E H SG Y N G E + ++ P T + Sbjct: 4063 --YRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIA-PFFTKPL 4119 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS---APSGGEASFN-LSLTAEH 628 +VV L C+ P + WF S A G AS + + Sbjct: 4120 RNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMND 4179 Query: 629 SGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSP 688 +GN++C A N + ++ S S + V P P ++ V+ +GS+P Sbjct: 4180 AGNFTCRATNSVGSKDS-----SGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTP 4234 Query: 689 I-LYWFYHEDVTLGKISAPSGGG---------ASFNLSLT-TEHSGIYSCEADN---GLE 734 + + WF G SGG +S L L T SG Y+C+ N G+E Sbjct: 4235 LTIRWF------KGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVE 4288 Query: 735 AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLG 794 L V P + + P GD +L C+ + G+P I +F D + Sbjct: 4289 CS----ANLFVKEPAT--FVEKLEPSQLLKKGDATQLACK-VTGTPPIKITWFANDREIK 4341 Query: 795 NRSS-----PSGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTL 835 S A L L+ + E SG Y CEA N G+ ++ + Sbjct: 4342 ESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVI 4388 Score = 90.1 bits (222), Expect = 9e-18 Identities = 205/905 (22%), Positives = 347/905 (38%), Gaps = 117/905 (12%) Query: 16 QFARTPRPIIFLQPPWTTVFQGE-------RVTLTCKGFRFYSPQKTKWYHRYLGKEILR 68 QF + P P++ L+ +T F+ + RV+ G + QK H + L Sbjct: 4862 QFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQK----HGISFIDGLA 4917 Query: 69 ETPDNILEVQESGEYRCQAQ--GSPLSSPVHLDFSSASLILQ--APLSVFEGDSVVLRCR 124 + V+ SG Y C+A+ S + L ++ P+ V + V L C Sbjct: 4918 TFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECE 4977 Query: 125 AKAEVTLNNTIYKNDNVLAFLNKRT--------DFHIPHACLKDNGAYRCTGYKESCCPV 176 T KN+ + K T + HI D G Y+C E Sbjct: 4978 VTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCS 5037 Query: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236 S V ++ F + + ++ V + T S P+ + +DDQ L Sbjct: 5038 CSTRVALKEPPSFIKKIENTTT--------VLKSSATFQSTVAGSPPISITWLKDDQILD 5089 Query: 237 LGWSLSPNF-------QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVL 289 ++ +F QI ++ + SG Y C+A + +++ VQ PA Sbjct: 5090 EDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKN---ESGVERCYAFLLVQEPAQ---- 5142 Query: 290 TLSPEKALNFEGTK---VTLHC---ETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISF 343 EKA + + T+ +TL C T E ++ L + + VP R+ S+ E + SF Sbjct: 5143 --IVEKAKSVDVTEKDPMTLECVVAGTPELKVKWL-KDGKQIVPSRYFSMSFENNVA-SF 5198 Query: 344 ---SLTTENSGNYYCTADNGLGAKPSKAV--SLSVTVPVSHPVLNLSSPEDLIFEGAKVT 398 S+ ++SG Y +N G+ A L +P S L+ + ++ G+ + Sbjct: 5199 RIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSF-TKKLTKMDKVL--GSSIH 5255 Query: 399 LHCEAQRGSLPILYQFHHEG----AALERRSANSAGGVAISF-SLTAEHSGNYYCTADNG 453 + C+ GSLPI Q+ +G + + R V++ +L E + NY C N Sbjct: 5256 MECKVS-GSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNV 5314 Query: 454 FGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP 513 G + L+V P P + +TV + +G+P +++ +D+ Sbjct: 5315 AGDDACSGI-LTVKEP---PSFLVKPGRQQAIPDSTVEFKA-ILKGTPPFKIKWFKDDVE 5369 Query: 514 LWSSSTPSV---GRVSF--SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPIL 568 L S + G SF +S+ +G Y C N G S L VT P P Sbjct: 5370 LVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSD-SCTTMLLVTEP---PKF 5425 Query: 569 TLRVPRAQAV-VGDLLELHCEAPRGSPPI-LYWFYHEDVTLGSSS-----APSGGEASFN 621 ++ ++ V GD L C+ GSP I + WF +E S S N Sbjct: 5426 VKKLEASKIVKAGDSSRLECKI-AGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMN 5484 Query: 622 LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681 +L+ E SG++ CEA N S + S VIV P+ + P + + + L CE Sbjct: 5485 -NLSTEDSGDFICEAQN---PAGSTSCSTKVIVK-EPPVFSSFPPIVETLKNAEVSLECE 5539 Query: 682 ALRGSSPILYWFYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQ 736 L G+ P +Y + L KI++ + + L++ T G Y C+A N + + Sbjct: 5540 -LSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD 5598 Query: 737 RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR 796 + T+K+ P P + G+ EL ++ G+ I ++ E + Sbjct: 5599 TC-VCTVKLKEP---PRFVSKLNSLTVVAGEPAELQA-SIEGAQPIFVQWLKEKEEVIRE 5653 Query: 797 SS------PSGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYI--TGLTANRSGP 847 S A+L + ++G Y C+ N G R TL + + ++GP Sbjct: 5654 SENIRITFVENVATLQFAKAEPANAGKYICQIKND-GGMRENMATLMVLEPAVIVEKAGP 5712 Query: 848 FATGV 852 V Sbjct: 5713 MTVTV 5717 Score = 87.8 bits (216), Expect = 4e-17 Identities = 207/911 (22%), Positives = 334/911 (36%), Gaps = 150/911 (16%) Query: 13 VSGQFARTPRPIIF---LQPPWTTVFQGERVTLTCKGFRFYSPQKT-KWYHRYLGKEILR 68 V G T P F L+P V G+ V+L C+ +P+ T WY G LR Sbjct: 6068 VCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAG--TPEITVSWYK---GDTKLR 6120 Query: 69 ETPD--------------NILEVQESGEYRCQAQ---GSPLSSPV------HLDFSSASL 105 TP+ N + + +SGEY C+A+ G+ S V L S A Sbjct: 6121 PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQ 6180 Query: 106 ILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL--------AFLNKRTDFHIPHAC 157 + +V G V L CR + Y++ +L +F++ I Sbjct: 6181 LKDIEQTV--GLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTD 6238 Query: 158 LKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV--LRASSFQPISGNPVTLTCETQL 215 L +G Y C+ + +S++ ++ +EP P ++ S I+G C Sbjct: 6239 LSHSGQYSCSA--SNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHV-- 6294 Query: 216 SLERSDVPLRFRFFRDDQTLGLGWSL-------SPNFQITAMWSKDSGFYWCKAATMPYS 268 P+R + +D++ + G + +P+ +I + DSG Y C+A Sbjct: 6295 ---TGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQAT----- 6346 Query: 269 VISDSPRSWIQVQIPASHP---VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG 325 +D + Q+ P V L K +G + L C+ + F ++ Sbjct: 6347 --NDVGKDMCSAQLSVKEPPKFVKKLEASKVAK-QGESIQLECKISGSPEIKVSWFRNDS 6403 Query: 326 VPLRHKSVRCERGASISFSLTT------ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH 379 H+S + S +L T E+SG+Y C A NG+G S + +L+V P Sbjct: 6404 E--LHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVG-DASCSTALTVKAP--- 6457 Query: 380 PVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAIS---- 435 PV +G+ V L CE G+ P + +R+ ++ I+ Sbjct: 6458 PVFTQKPSPVGALKGSDVILQCEIS-GTPPFEVVW-----VKDRKQVRNSKKFKITSKHF 6511 Query: 436 ------FSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGAT 489 +L A G Y+C A N G S S SV P ++ T G Sbjct: 6512 DTSLHILNLEASDVGEYHCKATNEVG---SDTCSCSVKFK-EPPRFVKKLSDTSTLIGDA 6567 Query: 490 VTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG-----HSGNYYCTAD 544 V L V+ P + + S + + +L G +SG Y C Sbjct: 6568 VELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIK 6627 Query: 545 NGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAV-VGDLLELHCEAPRGSPPILYWFYHE 603 N G + V + V P + P V G+ L C G+P + ++ + Sbjct: 6628 NDAGMRECSAV-----LTVLEPARIIEKPEPMTVTTGNPFALEC-VVTGTPELSAKWFKD 6681 Query: 604 DVTLGSSSAPS----GGEASFNLSLT-AEHSGNYSCEANNGLVAQHSDTISLSVIVPVSR 658 L + S AS + G YS E N V + + T+S+ V + Sbjct: 6682 GRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNS-VGKSNCTVSVHVSDRIVP 6740 Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPI-LYWFY--HEDVTLGKI-SAPSGGGASFN 714 P + A++G + L C + GS+PI + WF +E V+ K S+ S + N Sbjct: 6741 PSFIRKLKDVNAILGASVVLECR-VSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLN 6799 Query: 715 LS-LTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHC 773 LS L +GIY+C A N + V + V P + P + + + Sbjct: 6800 LSLLEPSDTGIYTCVAANVAGSDECSAV-----LTVQEPPSFEQTPDSVEVLPGMSLTFT 6854 Query: 774 EALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSL------------TAEHSGNYSCEA 821 +RG+P ++F G+R G S N+SL SG+YSC Sbjct: 6855 SVIRGTPPFKVKWFK-----GSRELVP-GESCNISLEDFVTELELFEVQPLESGDYSCLV 6908 Query: 822 DNGLGAQRSET 832 N G+ T Sbjct: 6909 TNDAGSASCTT 6919 Score = 87.0 bits (214), Expect = 8e-17 Identities = 144/568 (25%), Positives = 221/568 (38%), Gaps = 57/568 (10%) Query: 301 GTKVTLHCETQEDSLRTLYRFYHEGVPLR----HKSVRCERGASISFSLTTEN-SGNYYC 355 G V+L C+ T+ +Y LR +++ A++ F+ N SG Y C Sbjct: 6093 GDSVSLQCQVAGTPEITV-SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTC 6151 Query: 356 TADNGLGAKPSKAVSL--SVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQ 413 A+N +G SK V +P S L E + G VTL C GS PI Sbjct: 6152 KAENSIGTASSKTVFRIQERQLPPSF-ARQLKDIEQTV--GLPVTLTCRLN-GSAPIQVC 6207 Query: 414 FHHEGAAL---ERRSANSAGGVAISFSLTAE--HSGNYYCTADNGFGPQRSKAVSLSVTV 468 ++ +G L E + VA L + HSG Y C+A N G S A L+ Sbjct: 6208 WYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSA-RLTARE 6266 Query: 469 PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSP-QILYQFYHEDM-PLWSSSTPSVGRVS 526 P P + G + C V P +I + ++++ P + + VG Sbjct: 6267 PKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTP 6326 Query: 527 FS--FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV--GDL 582 + +G SG Y C A N G + V P ++ A V G+ Sbjct: 6327 HLRILKVGKGDSGQYTCQATNDVGKDMCSA-----QLSVKEPPKFVKKLEASKVAKQGES 6381 Query: 583 LELHCEAPRGSPPI-LYWF-----YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEA 636 ++L C+ GSP I + WF HE S S + N +AE SG+Y CEA Sbjct: 6382 IQLECKIS-GSPEIKVSWFRNDSELHESWKYNMSFINSVALLTIN-EASAEDSGDYICEA 6439 Query: 637 NNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPI-LYWFYH 695 +NG V S + +L+V P P+ T + A+ G + L CE + G+ P + W Sbjct: 6440 HNG-VGDASCSTALTVKAP---PVFTQKPSPVGALKGSDVILQCE-ISGTPPFEVVWVKD 6494 Query: 696 EDVTLG----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSR 751 KI++ + L+L G Y C+A N + + ++K P Sbjct: 6495 RKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSC-SVKFKEP--- 6550 Query: 752 PVLTLRAPGTHAAVGDLLELHC--EALRGSPLILYRFFHEDVTLGNRSSPS---GGASLN 806 P + T +GD +EL E + ++ + E + + S A+L Sbjct: 6551 PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQ 6610 Query: 807 L-SLTAEHSGNYSCEADNGLGAQRSETV 833 L S A +SG Y C+ N G + V Sbjct: 6611 LGSPEASNSGKYICQIKNDAGMRECSAV 6638 Score = 85.5 bits (210), Expect = 2e-16 Identities = 204/888 (22%), Positives = 317/888 (35%), Gaps = 145/888 (16%) Query: 34 VFQGERVTLTCKGFRFYSPQKTKWY----HRYLGKEILRETPDNI-------LEVQESGE 82 V QG+ TL K F KW+ LG + D + E ++SGE Sbjct: 4590 VTQGDPATLQVK-FSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGE 4648 Query: 83 YRCQAQGSPLSSPVHLDFSSASLILQAP-------LSVFEGDSVVLRCRAKAEVTLNNTI 135 Y + Q S + LI+ + +G + L C ++ Sbjct: 4649 YTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQW 4708 Query: 136 YKNDNVLAFLNK-RTDFHIPHACLK-------DNGAYRCTGYKESCCPVSSNTVKIQVQE 187 +K+D ++ K + FH A L+ D+G Y C+ ++ S + ++ Sbjct: 4709 FKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVK--- 4765 Query: 188 PFTRPVLRASSFQPISGNPVTLTCETQL-SLERSDVPLRFRFFRDDQTLGLG-----WS- 240 P Q NP T QL +L P+ ++F+D++ L G W Sbjct: 4766 ---EPPYFVEKPQSQDVNPNT---RVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKD 4819 Query: 241 -LSPNFQITAMWSKDSGFYWCK------AATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293 S + ++ A + DSG Y C+ AT ++ P +I+ PVL L Sbjct: 4820 DTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIK----KPSPVLVLR- 4874 Query: 294 EKALNFEGTKVTLHCE-TQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTT----- 347 G T C+ T +R + Y +G + + + G S L T Sbjct: 4875 ------NGQSTTFECQITGTPKIRVSW--YLDGNEI---TAIQKHGISFIDGLATFQISG 4923 Query: 348 ---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEA 403 ENSG Y C A N G S S+ + V P + + + + + + V L CE Sbjct: 4924 ARVENSGTYVCEARNDAGT-----ASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEV 4978 Query: 404 QRGSLPILYQFHHEGAALERRSANSAGGVAISFSL-----TAEHSGNYYCTADNGFGPQR 458 G+ P + + + F+L +G Y C N G Sbjct: 4979 T-GTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGG--- 5034 Query: 459 SKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILY------QFYHEDM 512 + S S V + P + E T + GSP I Q ED Sbjct: 5035 --SCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDD 5092 Query: 513 PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572 ++ S SV + S+ GHSG Y C A N G +R L V P + + Sbjct: 5093 NVYISFVDSVATLQIR-SVDNGHSGRYTCQAKNESGVERC-YAFLLVQEPAQ---IVEKA 5147 Query: 573 PRAQAVVGDLLELHCEAPRGSPPI-LYWFYHEDVTLGS---SSAPSGGEASFNL-SLTAE 627 D + L C G+P + + W + S S + ASF + S+ + Sbjct: 5148 KSVDVTEKDPMTLEC-VVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQ 5206 Query: 628 HSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSS 687 SG Y+ + N + D L V+ P T + + V+G + + C+ + GS Sbjct: 5207 DSGQYTFKVENDFGSSSCDAY-LRVLDQNIPPSFTKKLTKMDKVLGSSIHMECK-VSGSL 5264 Query: 688 PI-LYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746 PI WF K A + L H S E +N LE + + T KV+ Sbjct: 5265 PISAQWF--------KDGKEISTSAKYRLVC---HERSVSLEVNN-LELEDTANYTCKVS 5312 Query: 747 -----------VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGN 795 + V P L PG A+ D L+G+P ++F +DV L Sbjct: 5313 NVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVEL-- 5370 Query: 796 RSSP------SGGAS-LNL-SLTAEHSGNYSCEADNGLGAQRSETVTL 835 S P G S LNL S+ A +G Y+C N +G+ T+ L Sbjct: 5371 VSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLL 5418 Score = 84.3 bits (207), Expect = 5e-16 Identities = 184/814 (22%), Positives = 297/814 (36%), Gaps = 94/814 (11%) Query: 76 EVQESGEYRCQAQ---GSPLSSPVHLDFSSASLILQA-PLSVFEGDSVVLRCRAKAEVTL 131 E SG+Y CQ + G S V A +I + P++V G+ L C L Sbjct: 6615 EASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPEL 6674 Query: 132 NNTIYKNDNVLA--------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + +K+ L+ F+NK IP A + D G Y ++ S+ TV + Sbjct: 6675 SAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFE--VKNSVGKSNCTVSV 6732 Query: 184 QVQEPFTRP--VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSL 241 V + P + + I G V L C S P+ +F+D + G Sbjct: 6733 HVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGS-----APISVGWFQDGNEIVSGPKC 6787 Query: 242 SPNFQ-------ITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294 +F ++ + D+G Y C AA + S D + + VQ P S S E Sbjct: 6788 QSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS---DECSAVLTVQEPPSFEQTPDSVE 6844 Query: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASIS--FSLTTENSGN 352 T ++ T ++ ++ E VP ++ E + F + SG+ Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKW-FKGSRELVPGESCNISLEDFVTELELFEVQPLESGD 6903 Query: 353 YYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE-GAKVTLHCEAQRGSLPIL 411 Y C N G+ S + + V P + D E G+ + L G+ PI Sbjct: 6904 YSCLVTNDAGS-----ASCTTHLFVKEPATFVKRLADFSVETGSPIVLEA-TYTGTPPIS 6957 Query: 412 YQFHHEGAALERRSANSAGGVAISFSL-----TAEHSGNYYCTADNGFGPQRSKAVSLSV 466 + + + + S S L T E Y C +N G +A+ +SV Sbjct: 6958 VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEAL-VSV 7016 Query: 467 TVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVS 526 P + + L EA+ E AT L C+V G+P+I +Y E L S+ + + Sbjct: 7017 LEP-PYFIEPLEHVEAVIGEPAT--LQCKVD-GTPEIRISWYKEHTKLRSAPAYKMQFKN 7072 Query: 527 FSFSLTEG---HS--GNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGD 581 SL HS G Y C ADN G S V L + P ++ +G Sbjct: 7073 NVASLVINKVDHSDVGEYSCKADNSVGAVASSAV-LVIKARKLPPFFARKLKDVHETLGF 7131 Query: 582 LLELHCEAPRGSPPILYWF-----YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEA 636 + C P + W+ +D L +S + L H G Y+C A Sbjct: 7132 PVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQI-LQTDQSHIGQYNCSA 7190 Query: 637 NNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHE 696 +N L S + L + P + +G+ C + G++PI Sbjct: 7191 SNPL-GTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCH-VTGTAPI------- 7241 Query: 697 DVTLGKISAPSGGGASFNLSLTTE------------HSGIYSCEADNGLEAQRSEMVTLK 744 +T K + G ++ ++L +G Y+C A N + + S L Sbjct: 7242 KITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASN-IAGKDSCSAQLG 7300 Query: 745 VAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----P 799 V P R + L P + C+ + GSP I ++ ++ + S Sbjct: 7301 VQEP-PRFIKKLE-PSRIVKQDEFTRYECK-IGGSPEIKVLWYKDETEIQESSKFRMSFV 7357 Query: 800 SGGASLNL-SLTAEHSGNYSCEADNGLGAQRSET 832 A L + +L+ E SG+Y+CEA N G+ S T Sbjct: 7358 DSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391 Score = 83.2 bits (204), Expect = 1e-15 Identities = 176/822 (21%), Positives = 302/822 (36%), Gaps = 121/822 (14%) Query: 79 ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---LSVFEGDSVVLR-------CRAKAE 128 ++G+Y C A S+ D SA L +Q P + E +V + C+ Sbjct: 7278 DAGQYTCYA-----SNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGS 7332 Query: 129 VTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180 + YK++ + +F++ + + ++D+G Y C + + SS + Sbjct: 7333 PEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTS 7392 Query: 181 VKIQVQEPFTRPVLRAS--SFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLG 238 +K V+EP P+ R + + G V L CE Q P +++D + L G Sbjct: 7393 LK--VKEP---PIFRKKPHPIETLKGADVHLECELQ-----GTPPFHVSWYKDKRELRSG 7442 Query: 239 WS---LSPNF----QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291 +S NF I + + D G Y CKA V SD+ I ++ P P Sbjct: 7443 KKYKIMSENFLTSIHILNVDAADIGEYQCKATN---DVGSDTCVGSIALKAP---PRFVK 7496 Query: 292 SPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKS----VRCERGASISFS-LT 346 G +V L + ++ F +G +R E A++ FS + Sbjct: 7497 KLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVE 7556 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEAQR 405 N+G Y C N G + A T+ V P + PE + + G TL C Sbjct: 7557 PANAGKYTCQIKNDAGMQECFA-----TLSVLEPATIVEKPESIKVTTGDTCTLECTV-A 7610 Query: 406 GSLPILYQFHHEGAALERRSA------NSAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459 G+ + ++ +G L + N G+ I ++ SG Y N G + S Sbjct: 7611 GTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKI-INVAPSDSGVYSFEVQNPVG-KDS 7668 Query: 460 KAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSST 519 SL V+ P T E G++V + C+V GSP I ++HE + S Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY-GSPPISVSWFHEGNEISSGRK 7727 Query: 520 PSVGRVSFSFSLT-----EGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPR 574 + +LT E SG+Y C A N G + V P ++ P Sbjct: 7728 YQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECS-----APLTVREPPSFVQKPD 7782 Query: 575 AQAVVGDLLELHCEAPRGSPPI-LYWFYHEDVTLGSSSAPSGGEASFNL----------S 623 V+ +G+PP + WF GSS G + +L Sbjct: 7783 PMDVLTGTNVTFTSIVKGTPPFSVSWF------KGSSELVPGDRCNVSLEDSVAELELFD 7836 Query: 624 LTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVS--RPILTFRAPRAQAVVGDLLELHCE 681 + SG Y+C +N + S T L + P + + + + + ++ + Sbjct: 7837 VDTSQSGEYTCIVSNE-AGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILE------G 7889 Query: 682 ALRGSSPILYWFYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQ 736 G+ PI + + + I+ S T E +G Y+C +N A Sbjct: 7890 TFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIEN---AS 7946 Query: 737 RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR 796 + + ++ + + P + +VGD L C+ L G+P I ++ D L Sbjct: 7947 GKDSCSAQILI-LEPPYFVKQLEPVKVSVGDSASLQCQ-LAGTPEIGVSWYKGDTKLRPT 8004 Query: 797 SSPSGGASLNLS------LTAEHSGNYSCEADNGLGAQRSET 832 ++ N++ + SG Y C+A+N +G + T Sbjct: 8005 TTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAST 8046 Score = 82.0 bits (201), Expect = 2e-15 Identities = 190/825 (23%), Positives = 307/825 (37%), Gaps = 117/825 (14%) Query: 73 NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLN 132 N L ++SG++ C+AQ +P S +I++ P VF ++ AEV+L Sbjct: 5484 NNLSTEDSGDFICEAQ-----NPAGSTSCSTKVIVKEP-PVFSSFPPIVETLKNAEVSLE 5537 Query: 133 NTI----------YKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCC 174 + YK+ L A N T HI + D G Y C E Sbjct: 5538 CELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 5597 Query: 175 PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 TVK++ EP R V + +S ++G P E Q S+E + P+ ++ ++ + Sbjct: 5598 DTCVCTVKLK--EP-PRFVSKLNSLTVVAGEPA----ELQASIEGAQ-PIFVQWLKEKEE 5649 Query: 235 LGLGWSLSPNFQITAMWS-----------KDSGFYWCKAATMPYSVISDSPRSWIQVQIP 283 + S N +IT + + ++G Y C+ + +D + Sbjct: 5650 V---IRESENIRITFVENVATLQFAKAEPANAGKYICQ-------IKNDGGMRENMATLM 5699 Query: 284 ASHPVLTLSPEKALNFE-GTKVTLHCE---TQEDSLRTLYRFYHEGVPL----RHKSVRC 335 P + + + G TL C+ T E S+ +Y +G L +HK Sbjct: 5700 VLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVE----WYKDGKLLTSSQKHKFSFY 5755 Query: 336 ERGASISF-SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEG 394 + +S+ S+ +++G Y N +G AV + V+ P G Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAV-VDVSDRAVPPSFTRRLKNTGGVLG 5814 Query: 395 AKVTLHCEAQRGSLPILYQFHHE------GAALERRSANSAGGVAISFSLTAEHSGNYYC 448 A L C+ GS PI + HE GA + +++ + ++ SL + GNY C Sbjct: 5815 ASCILECKVA-GSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLN-SLDSSDMGNYTC 5872 Query: 449 TADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFY 508 A N G +AV L+V P S V E L + T T V RG+P ++ Sbjct: 5873 VAANVAGSDECRAV-LTVQEPPSF-VKEPEPLEVLPGKNVTFT---SVIRGTPPFKVNWF 5927 Query: 509 HEDMPLWSSST------PSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVP 562 L +V + F++ SG Y C N G Q S LFV P Sbjct: 5928 RGARELVKGDRCNIYFEDTVAELEL-FNIDISQSGEYTCVVSNNAG-QASCTTRLFVKEP 5985 Query: 563 VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFN- 621 + R+ G + L G+ PI + + + +S + Sbjct: 5986 AA---FLKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTC 6041 Query: 622 ----LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLE 677 L+ T +G YSCE N + + +++ + P +A VGD + Sbjct: 6042 ILEILNSTKRDAGQYSCEIEN----EAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVS 6097 Query: 678 LHCEALRGSSPILYWFYHEDVTLGKIS------APSGGGASFNLSLTTEHSGIYSCEADN 731 L C+ + G+ I +Y D L + FN + SG Y+C+A+N Sbjct: 6098 LQCQ-VAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFN-KVNINDSGEYTCKAEN 6155 Query: 732 GLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDV 791 + S+ V ++ P + VG + L C L GS I ++ + V Sbjct: 6156 SIGTASSKTV-FRIQERQLPPSFARQLKDIEQTVGLPVTLTCR-LNGSAPIQVCWYRDGV 6213 Query: 792 TLGN-----RSSPSGGASLNLSLT-AEHSGNYSCEADNGLGAQRS 830 L + S A+L + T HSG YSC A N LG S Sbjct: 6214 LLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASS 6258 Score = 80.5 bits (197), Expect = 7e-15 Identities = 164/814 (20%), Positives = 294/814 (36%), Gaps = 102/814 (12%) Query: 80 SGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEVT 130 SG Y CQA+ ++ A L++Q P + V E D + L C Sbjct: 5115 SGRYTCQAKNES-----GVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPE 5169 Query: 131 LNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRC---TGYKESCCPVSSN 179 L K+ + +F N F I +D+G Y + S C Sbjct: 5170 LKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLR 5229 Query: 180 TVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGW 239 + + FT+ + + + G+ + + C+ SL P+ ++F+D + + Sbjct: 5230 VLDQNIPPSFTK---KLTKMDKVLGSSIHMECKVSGSL-----PISAQWFKDGKEISTSA 5281 Query: 240 SL-------SPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLS 292 S + ++ + +D+ Y CK + + D+ + V+ P P + Sbjct: 5282 KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGD---DACSGILTVKEP---PSFLVK 5335 Query: 293 PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASIS------FSLT 346 P + + V + + +++ + V L +C G S +S+ Sbjct: 5336 PGRQQAIPDSTVEFKAILKGTPPFKI-KWFKDDVELV-SGPKCFIGLEGSTSFLNLYSVD 5393 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406 +G Y C N +G+ + L P L S ++ G L C+ G Sbjct: 5394 ASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASK---IVKAGDSSRLECKIA-G 5449 Query: 407 SLPIL---YQFHHEGAALERRSANSAGGVAI--SFSLTAEHSGNYYCTADNGFGPQRSKA 461 S I ++ HE A ++ VA+ +L+ E SG++ C A N G + Sbjct: 5450 SPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAG-----S 5504 Query: 462 VSLSVTVPVSHPVLTLSSAEAL-TFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTP 520 S S V V P + S + T + A V+L CE+ G+P +Y + L SS Sbjct: 5505 TSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELS-GTPPFEVVWYKDKRQLRSSKKY 5563 Query: 521 SVGRVSFSFSL-----TEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRA 575 + +F S+ G Y+C A N G V ++ + P P ++ Sbjct: 5564 KIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTC-VCTVKLKEP---PRFVSKLNSL 5619 Query: 576 QAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS------APSGGEASFNLSLTAEHS 629 V G+ EL P + W ++ + S + F + A ++ Sbjct: 5620 TVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPA-NA 5678 Query: 630 GNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPI 689 G Y C+ N + +L V+ P ++ +A VG+ L C+ Sbjct: 5679 GKYICQIKND-GGMRENMATLMVLEPA---VIVEKAGPMTVTVGETCTLECKVAGTPELS 5734 Query: 690 LYWFYHEDVTLG----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKV 745 + W+ + K S + + LS+ + +G Y+ + N + + S + V Sbjct: 5735 VEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNV-GKSSCTAVVDV 5793 Query: 746 AVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASL 805 + P T R T +G L C+ SP+ + +FHE + + + S Sbjct: 5794 SDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISV-AWFHEKTKIVSGAKYQTTFSD 5852 Query: 806 NL------SLTAEHSGNYSCEADNGLGAQRSETV 833 N+ SL + GNY+C A N G+ V Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886 Score = 80.5 bits (197), Expect = 7e-15 Identities = 192/836 (22%), Positives = 312/836 (37%), Gaps = 111/836 (13%) Query: 75 LEVQESGEYRCQAQGS--PLSSPVHLDFSSASLILQA--PLSVFEGDSVVLRCRAKAEVT 130 L V++SG+Y C+A + SS L + + P+ +G V L C + Sbjct: 7368 LSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPP 7427 Query: 131 LNNTIYKNDNVLAFLNK--------RTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTV- 181 + + YK+ L K T HI + D G Y+C + V S+T Sbjct: 7428 FHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATND----VGSDTCV 7483 Query: 182 -KIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD-----QTL 235 I ++ P R V + S + G V L Q ++E ++ P+ +F+D ++ Sbjct: 7484 GSIALKAP-PRFVKKLSDISTVVGKEVQL----QTTIEGAE-PISVVWFKDKGEIVRESD 7537 Query: 236 GLGWSLSPN---FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP-VLTL 291 + S S N Q + + ++G Y C+ + +D+ + P + Sbjct: 7538 NIWISYSENIATLQFSRVEPANAGKYTCQ-------IKNDAGMQECFATLSVLEPATIVE 7590 Query: 292 SPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISF-------- 343 PE G TL C T + +++ +G K + + ISF Sbjct: 7591 KPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDG-----KELTSDNKYKISFFNKVSGLK 7644 Query: 344 --SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHC 401 ++ +SG Y N +G K S SL V+ P E G+ V + C Sbjct: 7645 IINVAPSDSGVYSFEVQNPVG-KDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703 Query: 402 EAQRGSLPILYQFHHEG----AALERRSANSAGGVAISFSLTAE-HSGNYYCTADNGFGP 456 + GS PI + HEG + + ++ + A++ ++ E SG+Y C A N G Sbjct: 7704 KVY-GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGS 7762 Query: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516 A L+V P S V + LT T T + +G+P ++ L Sbjct: 7763 DECSA-PLTVREPPSF-VQKPDPMDVLTGTNVTFT---SIVKGTPPFSVSWFKGSSELVP 7817 Query: 517 ------SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTL 570 S SV + F + SG Y C N G + S L++ P Sbjct: 7818 GDRCNVSLEDSVAELEL-FDVDTSQSGEYTCIVSNEAG-KASCTTHLYIKAPAK---FVK 7872 Query: 571 RVPRAQAVVGDLLELHCEAPRGSPPILYWFYHE--DVTLGSSSAPSGGEASFNL---SLT 625 R+ G L L G+PPI + +VT + E S L S T Sbjct: 7873 RLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSST 7931 Query: 626 AEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRG 685 E +G Y+C N A D+ S +++ + P + + VGD L C+ L G Sbjct: 7932 VEDAGQYNCYIEN---ASGKDSCSAQILI-LEPPYFVKQLEPVKVSVGDSASLQCQ-LAG 7986 Query: 686 SSPILYWFYHED-----VTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740 + I +Y D T K+ + + SG Y C+A+N + + S Sbjct: 7987 TPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSV-GEVSAS 8045 Query: 741 VTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800 L V P + + VG + C A+ GS I ++ + L + SP+ Sbjct: 8046 TFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC-AISGSEPISVSWYKDGKPL--KDSPN 8102 Query: 801 -------GGASLNLSLTAEH-SGNYSCEADNGLGAQRSETVTLYITGLTANRSGPF 848 A+LN+ T +G YSC A N +G+ S + LT ++ PF Sbjct: 8103 VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLI----LTEGKNPPF 8154 Score = 77.4 bits (189), Expect = 6e-14 Identities = 183/852 (21%), Positives = 303/852 (35%), Gaps = 126/852 (14%) Query: 54 KTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQ---AP 110 K ++++ G +I+ P +SG Y + Q +PV D +ASL + P Sbjct: 7633 KISFFNKVSGLKIINVAPS------DSGVYSFEVQ-----NPVGKDSCTASLQVSDRTVP 7681 Query: 111 LSV---------FEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACL--- 158 S G SVV+ C+ ++ + + N ++ K + C Sbjct: 7682 PSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTV 7741 Query: 159 -----KDNGAYRC-----TGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVT 208 D+G Y C G E P++ VQ+P VL +G VT Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVL--------TGTNVT 7793 Query: 209 LTCETQLSLERSDVPLRFRFFRDDQTLGLG----WSLSPNFQITAMWSKD---SGFYWCK 261 T S+ + P +F+ L G SL + ++ D SG Y C Sbjct: 7794 FT-----SIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848 Query: 262 AATMPYSVISDSPRSWIQVQIPASHPV----LTLSPEKALNFEGTKVTLHCETQEDSLRT 317 + S + + ++ PA ++ K L EGT T S+ Sbjct: 7849 VSNEAGKA---SCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGT----FTGTPPISVTW 7901 Query: 318 LYRFYHEGVPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVP 376 + R E+ A + S T E++G Y C +N G S S + Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKD-----SCSAQIL 7956 Query: 377 VSHPVLNLSSPEDL-IFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSA-------NS 428 + P + E + + G +L C Q P + ++G R + N+ Sbjct: 7957 ILEPPYFVKQLEPVKVSVGDSASLQC--QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNN 8014 Query: 429 AGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGA 488 + + + SG Y C A+N G + S + L+V P + + G Sbjct: 8015 VATLVFN-QVDINDSGEYICKAENSVG-EVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072 Query: 489 TVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFS-----FSLTEGHSGNYYCTA 543 V C + GS I +Y + PL S + + F +G Y CTA Sbjct: 8073 PVVFDCAIS-GSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTA 8131 Query: 544 DNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHE 603 N G S L +T + P +R+ AVVG+ + C P + W Sbjct: 8132 TNPIGSASSSA-RLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSW---- 8186 Query: 604 DVTLGSSSAPSGGEASFNLSLTAEH----------SGNYSCEANNGLVAQHSDTISLSVI 653 S SGG+ + + H SG Y+C A N V + S T L++ Sbjct: 8187 --AKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNE-VGKDSCTAQLNIK 8243 Query: 654 VPVSRPILTFR-APRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGAS 712 + P T R + + G+ +L + GS PI +Y ++ + S + Sbjct: 8244 ERLIPPSFTKRLSETVEETEGNSFKLEGR-VAGSQPITVAWYKNNIEIQPTSNCEITFKN 8302 Query: 713 FNLSLTTEHSG-----IYSCEADNGLEAQRSEMVTLKVAV--PVSRPVLTLRAPGTHAAV 765 L L +G +Y+C+ N S + T + + P PV + Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAG---SALCTSSIVIKEPKKPPVFDQHLTPVTVSE 8359 Query: 766 GDLLELHCEALRGSPL-ILYRFFHEDVTLGNRSS---PSGGASLNLSLTAE-HSGNYSCE 820 G+ ++L C P+ I + ++ +R S SG A L L A+ SG+Y C+ Sbjct: 8360 GEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCK 8419 Query: 821 ADNGLGAQRSET 832 A N G+ +++ Sbjct: 8420 ASNVAGSDTTKS 8431 Score = 76.6 bits (187), Expect = 1e-13 Identities = 195/841 (23%), Positives = 311/841 (36%), Gaps = 131/841 (15%) Query: 79 ESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF----------EGDSVVLRCRAKAE 128 +SG+Y CQA ++ V D SA L ++ P +G+S+ L C+ Sbjct: 6337 DSGQYTCQA-----TNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGS 6391 Query: 129 VTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180 + + ++ND+ L +F+N I A +D+G Y C + S Sbjct: 6392 PEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTA 6451 Query: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS 240 + ++ FT+ + S + G+ V L CE P + +D + + Sbjct: 6452 LTVKAPPVFTQ---KPSPVGALKGSDVILQCEIS-----GTPPFEVVWVKDRKQV----R 6499 Query: 241 LSPNFQITA-----------MWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVL 289 S F+IT+ + + D G Y CKA V SD+ ++ + P V Sbjct: 6500 NSKKFKITSKHFDTSLHILNLEASDVGEYHCKATN---EVGSDTCSCSVKFKEPPRF-VK 6555 Query: 290 TLSPEKALNFEGTKVTLHCET-QEDSLRTLYRFYHEGVPLRHKSVRCERGASISF----- 343 LS L + ++ E Q S+ L R + +R ISF Sbjct: 6556 KLSDTSTLIGDAVELRAIVEGFQPISVVWLKD--------RGEVIRESENTRISFIDNIA 6607 Query: 344 -----SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKV 397 S NSG Y C N G + AV + V P + PE + + G Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAV-----LTVLEPARIIEKPEPMTVTTGNPF 6662 Query: 398 TLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLT---AEHS--GNYYCTADN 452 L C G+ + ++ +G L S + + SL AE S G Y N Sbjct: 6663 ALECVVT-GTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKN 6721 Query: 453 GFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDM 512 G VS+ V+ + P + GA+V L C V GS I ++ + Sbjct: 6722 SVGKSNC-TVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVS-GSAPISVGWFQDGN 6779 Query: 513 PLWSS----STPSVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPI 567 + S S+ S + + SL E +G Y C A N G V + V P Sbjct: 6780 EIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAV-----LTVQEPP 6834 Query: 568 LTLRVPRAQAVVGDLLELHCEAPRGSPPI-LYWFY-HEDVTLGSSSAPSGGEASFNLSLT 625 + P + V+ + RG+PP + WF ++ G S S + L L Sbjct: 6835 SFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELF 6894 Query: 626 AEH---SGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 SG+YSC LV + + S + + V P TF A V + EA Sbjct: 6895 EVQPLESGDYSC-----LVTNDAGSASCTTHLFVKEPA-TFVKRLADFSVETGSPIVLEA 6948 Query: 683 L-RGSSPILYWFYHEDVTLGK-----ISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQ 736 G+ PI + ++ + + I+ L T E YSC +N + Sbjct: 6949 TYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIEN----E 7004 Query: 737 RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR 796 + + + + P A +G+ L C+ + G+P I ++ E L R Sbjct: 7005 AGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCK-VDGTPEIRISWYKEHTKL--R 7061 Query: 797 SSPS-------GGASLNLSLTAEHS--GNYSCEADNGLGAQRSETVTLYITGLTANRSGP 847 S+P+ ASL ++ +HS G YSC+ADN +GA S V + + A + P Sbjct: 7062 SAPAYKMQFKNNVASLVIN-KVDHSDVGEYSCKADNSVGAVASSAVLV----IKARKLPP 7116 Query: 848 F 848 F Sbjct: 7117 F 7117 Score = 72.8 bits (177), Expect = 1e-12 Identities = 186/827 (22%), Positives = 307/827 (37%), Gaps = 121/827 (14%) Query: 75 LEVQESGEYRCQAQ---GSPLSSPVHLDFSSASLI--LQAPLSVFEGDSVVLRCRAKAEV 129 ++ ++G+Y C GS + + L + L+A V GDS L C+ Sbjct: 5392 VDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSP 5451 Query: 130 TLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTV 181 + ++N++ L F++ + + +D+G + C ++ +S + Sbjct: 5452 EIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEA--QNPAGSTSCST 5509 Query: 182 KIQVQEPFTRPVLRASSFQPI----SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGL 237 K+ V+EP PV SSF PI V+L CE P +++D + L Sbjct: 5510 KVIVKEP---PVF--SSFPPIVETLKNAEVSLECELS-----GTPPFEVVWYKDKRQLRS 5559 Query: 238 GWSL---SPNFQ----ITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290 S NF I + + D G Y CKA V SD+ ++++ P V Sbjct: 5560 SKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQN---EVGSDTCVCTVKLKEPPRF-VSK 5615 Query: 291 LSPEKALNFEGTKVTLHCETQEDS----LRTLYRFYHEGVPLRHKSVRCERGASISFSLT 346 L+ + E ++ E + L+ E +R V E A++ F+ Sbjct: 5616 LNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFV--ENVATLQFAKA 5673 Query: 347 TE-NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEAQ 404 N+G Y C N G + + A T+ V P + + + + G TL C+ Sbjct: 5674 EPANAGKYICQIKNDGGMRENMA-----TLMVLEPAVIVEKAGPMTVTVGETCTLECKVA 5728 Query: 405 RGSLPILYQFHHEGAALERRSA------NSAGGVAISFSLTAEHSGNYYCTADNGFGPQR 458 G+ + +++ +G L N + I S+ + +G Y N G Sbjct: 5729 -GTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRI-LSVERQDAGTYTFQVQNNVGKSS 5786 Query: 459 SKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS 518 AV + V+ P T GA+ L C+V SP I ++HE + S + Sbjct: 5787 CTAV-VDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSP-ISVAWFHEKTKIVSGA 5844 Query: 519 ------TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572 + +V + + SL GNY C A N G V + V P ++ Sbjct: 5845 KYQTTFSDNVCTLQLN-SLDSSDMGNYTCVAANVAGSDECRAV-----LTVQEPPSFVKE 5898 Query: 573 PRAQAVVGDLLELHCEAPRGSPPI-LYWFYHEDVTLGSSSAPSGGEAS------------ 619 P V+ RG+PP + WF G+ G + Sbjct: 5899 PEPLEVLPGKNVTFTSVIRGTPPFKVNWFR------GARELVKGDRCNIYFEDTVAELEL 5952 Query: 620 FNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELH 679 FN+ ++ SG Y+C +N Q S T L V P + R G + L Sbjct: 5953 FNIDIS--QSGEYTCVVSNN-AGQASCTTRLFVKEPAA---FLKRLSDHSVEPGKSIILE 6006 Query: 680 CEALRGSSPILYWFYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADNGLE 734 G+ PI + + + I L+ T +G YSCE +N E Sbjct: 6007 -STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIEN--E 6063 Query: 735 AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLG 794 A R V + + P AAVGD + L C+ + G+P I ++ D L Sbjct: 6064 AGRD--VCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQ-VAGTPEITVSWYKGDTKL- 6119 Query: 795 NRSSP-------SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETV 833 R +P + A+L + + SG Y+C+A+N +G S+TV Sbjct: 6120 -RPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTV 6165 Score = 72.4 bits (176), Expect = 2e-12 Identities = 193/911 (21%), Positives = 331/911 (36%), Gaps = 169/911 (18%) Query: 14 SGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR----------YLG 63 SG P +P V G V L F+ +P +W+ Y+ Sbjct: 4197 SGALIVQEPPSFVTKPGSKDVLPGSAVCLKST-FQGSTPLTIRWFKGNKELVSGGSCYIT 4255 Query: 64 KEILRETPD-NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFE------- 115 KE L + + +++ +SG Y C+ S ++ V SA+L ++ P + E Sbjct: 4256 KEALESSLELYLVKTSDSGTYTCKV--SNVAGGVEC---SANLFVKEPATFVEKLEPSQL 4310 Query: 116 ---GDSVVLRCRAKAEVTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAY 164 GD+ L C+ + T + ND + +F+ + ++D+G Y Sbjct: 4311 LKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEY 4370 Query: 165 RCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDV-P 223 C E+ S+ V ++ FT+ F+PI V + L E + P Sbjct: 4371 MCEAQNEAGSDHCSSIVIVKESPYFTK------EFKPIE---VLKEYDVMLLAEVAGTPP 4421 Query: 224 LRFRFFRDDQTLGLGWSLSP-------NFQITAMWSKDSGFYWCKAATMPYSVISDS--- 273 +F+D+ L G + QI + D+G Y C+ S I + Sbjct: 4422 FEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVT 4481 Query: 274 ---PRSWIQVQIPASHPV--------LTLSPEKALNFEGTKVTLHCETQEDSLRTLYR-- 320 P S+I+ +I ++ + TL + K + T++D++R + Sbjct: 4482 LREPPSFIK-KIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEI-TEDDNIRMTFENN 4539 Query: 321 ---FYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPV 377 Y G+ ++H G Y C A N G + A+ LSV P Sbjct: 4540 VASLYLSGIEVKH-------------------DGKYVCQAKNDAGIQRCSAL-LSVKEPA 4579 Query: 378 SHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALE-----RRSANSAGGV 432 + + + + +G TL + G+ I ++ +G L + S + Sbjct: 4580 T---ITEEAVSIDVTQGDPATLQVKFS-GTKEITAKWFKDGQELTLGSKYKISVTDTVSI 4635 Query: 433 AISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTL 492 S + SG Y N G KA ++V + P T + + +G+ + L Sbjct: 4636 LKIISTEKKDSGEYTFEVQNDVGRSSCKA-RINVLDLIIPPSFTKKLKKMDSIKGSFIDL 4694 Query: 493 HCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF---------SLTEG-HSGNYYCT 542 C + GS I Q++ +D + +S + FSF S EG SG Y C+ Sbjct: 4695 EC-IVAGSHPISIQWFKDDQEISASE-----KYKFSFHDNTAFLEISQLEGTDSGTYTCS 4748 Query: 543 ADNGFGPQRS------EVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPI 596 A N G + + FV P S+ + + +A+VG G+ P+ Sbjct: 4749 ATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVG-----------GTAPM 4797 Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSL-----TAEHSGNYSCEANNGLVAQHSDTISLS 651 ++ ++ L S +A S + + SL A SG Y C+ +N + T + Sbjct: 4798 TIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDV-----GTATSK 4852 Query: 652 VIVPVSRPILTFRAPRAQAVV--GDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGG 709 + V P + P V+ G C+ + G+ I +Y + +I+A Sbjct: 4853 ATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQ-ITGTPKIRVSWYLDG---NEITAIQKH 4908 Query: 710 GASFNLSLTT--------EHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGT 761 G SF L T E+SG Y CEA N S + LKV P P Sbjct: 4909 GISFIDGLATFQISGARVENSGTYVCEARND-AGTASCSIELKVKEP---PTFIRELKPV 4964 Query: 762 HAAVGDLLELHCEALRGSPL-ILYRFFHEDVTLGNRSSPSGGASL-NLSLT---AEHSGN 816 +EL CE P + + + ++ + + + S+ NL +T +G Sbjct: 4965 EVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGE 5024 Query: 817 YSCEADNGLGA 827 Y C N G+ Sbjct: 5025 YQCIVSNEGGS 5035 Score = 66.2 bits (160), Expect = 1e-10 Identities = 170/820 (20%), Positives = 309/820 (37%), Gaps = 121/820 (14%) Query: 75 LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS---------VFEGDSVVLRCRA 125 +++ ++G + C+A S S SS +LI+Q P S V G +V L+ Sbjct: 4175 VDMNDAGNFTCRATNSVGSKD-----SSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTF 4229 Query: 126 KAEVTLNNTIYKNDNVLA-----FLNKR---TDFHIPHACLKDNGAYRCTGYKESCCPVS 177 + L +K + L ++ K + + D+G Y C + Sbjct: 4230 QGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK--VSNVAGGV 4287 Query: 178 SNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGL 237 + + V+EP T S G+ L C+ P++ +F +D+ + Sbjct: 4288 ECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVT-----GTPPIKITWFANDREIKE 4342 Query: 238 GWSLSPNF-------QITAMWSKDSGFYWCKAATMPYS-------VISDSP---RSWIQV 280 +F ++T + +DSG Y C+A S ++ +SP + + + Sbjct: 4343 SSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPI 4402 Query: 281 QIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340 ++ + V+ L+ GT +++++ R Y + S++ Sbjct: 4403 EVLKEYDVMLLA-----EVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQI----- 4452 Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400 ++G Y C N +G+ A +++ P S + + S L G Sbjct: 4453 --LKFVAADAGEYQCRVTNEVGSSICSA-RVTLREPPSF-IKKIESTSSL--RGGTAAFQ 4506 Query: 401 CEAQRGSLPILYQFHHEGAALERRS------ANSAGGVAISFSLTAEHSGNYYCTADNGF 454 +GSLPI + + + N+ + +S + +H G Y C A N Sbjct: 4507 ATL-KGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLS-GIEVKHDGKYVCQAKNDA 4564 Query: 455 GPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPL 514 G QR A+ LSV P + +T + +G TL + G+ +I +++ + L Sbjct: 4565 GIQRCSAL-LSVKEPAT---ITEEAVSIDVTQGDPATLQVKFS-GTKEITAKWFKDGQEL 4619 Query: 515 -----WSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQ--RSEVVSLFVTVPVSRPI 567 + S + S + SG Y N G ++ + L + +P P Sbjct: 4620 TLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIP---PS 4676 Query: 568 LTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS----APSGGEASFNLS 623 T ++ + ++ G ++L C GS PI ++ +D + +S + A +S Sbjct: 4677 FTKKLKKMDSIKGSFIDLEC-IVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEIS 4735 Query: 624 -LTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 L SG Y+C A N A H+ S + V P P++Q V + Sbjct: 4736 QLEGTDSGTYTCSATN--KAGHN---QCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKAL 4790 Query: 683 LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSL-----TTEHSGIYSCEADNGLEAQR 737 + G++P+ ++ ++ L +A S + SL SG Y C+ N + Sbjct: 4791 VGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTAT 4850 Query: 738 SEMVTLKVAVPVS-----RPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHE--D 790 S+ TL V P PVL LR G C+ + G+P I ++ + + Sbjct: 4851 SK-ATLFVKEPPQFIKKPSPVLVLRN-------GQSTTFECQ-ITGTPKIRVSWYLDGNE 4901 Query: 791 VTLGNRSSPS---GGASLNLS-LTAEHSGNYSCEADNGLG 826 +T + S G A+ +S E+SG Y CEA N G Sbjct: 4902 ITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAG 4941 Score = 49.3 bits (116), Expect = 2e-05 Identities = 127/620 (20%), Positives = 211/620 (34%), Gaps = 130/620 (20%) Query: 300 EGTKVTLHCETQEDSLRTLYRFYHEGVPL------RHKSVRCERGASISFSLTTENSGNY 353 E + + E ED + +Y +G+ + RHK V R + S T ++ Sbjct: 3160 EKQRAVVEFEVNEDDVDA--HWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGE 3217 Query: 354 YCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------IFEGA---KVTLH 400 Y + + +V+L V P VL P + + G K++ + Sbjct: 3218 YTF----VAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWY 3273 Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460 E Q S +F H+G + E + Y C A N +G + Sbjct: 3274 KEEQLLSTGFKCKFLHDGQEY----------TLLLIEAFPEDAAVYTCEAKNDYGVATTS 3323 Query: 461 AVSLSVTVP----------VSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHE 510 A SLSV VP V P + + +T EG C V + +Y + Sbjct: 3324 A-SLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVS--GTDLKVSWYSK 3380 Query: 511 DMPLWSSSTPSVGRVSFSFSLTEGHS-----GNYYCTADNGFGPQRSEVVSLFVTVPVS- 564 D + S + + ++ L + G Y A N G Q S +L + P S Sbjct: 3381 DKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVG-QVSSTANLSLEAPESI 3439 Query: 565 ---------------RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF------YHE 603 P++ ++ + +G L + CE WF Y Sbjct: 3440 LHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES 3499 Query: 604 D-VTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILT 662 D ++ SS S E L G Y+C+A+N S T +L+V P Sbjct: 3500 DKCSIRSSKYISSLEI---LRTQVVDCGEYTCKASNEY-GSVSCTATLTV-TEAYPPTFL 3554 Query: 663 FRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNL------- 715 R VG + C +P++ + +D G +PS + Sbjct: 3555 SRPKSLTTFVGKAAKFICTVT--GTPVIETIWQKD---GAALSPSPNWRISDAENKHILE 3609 Query: 716 --SLTTEHSGIYSCEADN--GLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLEL 771 +LT + G+YSC+A N G + ++E++ + +P +A+ + L Sbjct: 3610 LSNLTIQDRGVYSCKASNKFGADICQAELII------IDKPHFIKELEPVQSAINKKVHL 3663 Query: 772 HCEALRGSPLIL--------------YRFFHEDVTLGNRSSPSGGASLNLSLT-AEHSGN 816 C+ + + Y+ ED A+L + L + SG Sbjct: 3664 ECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKI----------ATLEIPLAKLKDSGT 3713 Query: 817 YSCEADNGLGAQR-SETVTL 835 Y C A N G+ S TVT+ Sbjct: 3714 YVCTASNEAGSSSCSATVTV 3733 Score = 44.7 bits (104), Expect = 4e-04 Identities = 96/455 (21%), Positives = 162/455 (35%), Gaps = 62/455 (13%) Query: 73 NILEVQESGEYRCQAQGS--PLSSPVHLDFSSASLILQAPLSVFE-----GDSVVLRCRA 125 N +++ +SGEY C+A+ S +S+ L L + + G VV C Sbjct: 8021 NQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAI 8080 Query: 126 KAEVTLNNTIYKNDNVL--------AFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV- 176 ++ + YK+ L +FL+ +I G Y CT P+ Sbjct: 8081 SGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATN----PIG 8136 Query: 177 -SSNTVKIQVQEPFTRPV--LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ 233 +S++ ++ + E P +R + + G C P++ + +D + Sbjct: 8137 SASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHV-----TGTQPIKVSWAKDSR 8191 Query: 234 TLGLGWSL-------SPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASH 286 + G S + + + DSG Y C A V DS + + ++ Sbjct: 8192 EIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN---EVGKDSCTAQLNIKERLIP 8248 Query: 287 PVLTLS-PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSL 345 P T E EG L T+ +Y + ++ S CE I+F Sbjct: 8249 PSFTKRLSETVEETEGNSFKLEGRVAGSQPITV-AWYKNNIEIQPTS-NCE----ITFKN 8302 Query: 346 TT----------ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395 T ++G Y C N G+ + S+ + P PV + + EG Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTS-SIVIKEPKKPPVFDQHLTPVTVSEGE 8361 Query: 396 KVTLHCEAQRGSLPILYQFHHEGAAL---ERRSANSAGGVAI--SFSLTAEHSGNYYCTA 450 V L C Q GS PI Q+ G + +R S + A G A+ + SG+Y C A Sbjct: 8362 YVQLSCHVQ-GSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKA 8420 Query: 451 DNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTF 485 N G +K+ P P ++ + F Sbjct: 8421 SNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLF 8455 Score = 42.4 bits (98), Expect = 0.002 Identities = 39/167 (23%), Positives = 70/167 (41%), Gaps = 15/167 (8%) Query: 672 VGDLLELHCEALRGSSPILYWF-YHEDVTLGKISAPSGGGASFNLSLTTEHS---GIYSC 727 +G+ +L C+ + P + W+ + +++ + S G + L++ TE G+Y+C Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 30605 Query: 728 EADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFF 787 A N + + L A P P L+ + AVG L LH + G P+ +F Sbjct: 30606 IATNEVGEVETSSKLLLQATPQFHPGYPLKEK-YYGAVGSTLRLHVMYI-GRPVPAMTWF 30663 Query: 788 H--------EDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLG 826 H E++T+ N + N+ H+G Y + N G Sbjct: 30664 HGQKLLQNSENITIENTEHYTHLVMKNVQ-RKTHAGKYKVQLSNVFG 30709 Score = 39.7 bits (91), Expect = 0.014 Identities = 49/193 (25%), Positives = 74/193 (38%), Gaps = 18/193 (9%) Query: 473 PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF--- 529 P T + EG+T T + G P ++ + + +S+ P V ++SFS Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHIS-GFPVPEVSWFRDGQVISTSTLPGV-QISFSDGRA 63 Query: 530 -----SLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLE 584 ++T+ +SG Y A NG G Q + L V + P R+ G + Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSG-QATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122 Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSS---SAPSGGEASFNLSLTA--EHSGNYSCEANNG 639 L G P + FY + + SS G+ L A E SG YS A N Sbjct: 123 LQVRV-TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181 Query: 640 LVAQHSDTISLSV 652 V + + T L V Sbjct: 182 -VGRATSTAELLV 193 Score = 36.2 bits (82), Expect = 0.15 Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 11/109 (10%) Query: 462 VSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS---- 517 V V +PV+ P L EG +VTL C + G P +Y ED + SS Sbjct: 932 VPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHIS-GYPSPTVTWYREDYQIESSIDFQ 990 Query: 518 --STPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVS 564 + R+ + E SG + C+A N G + S ++ V VS Sbjct: 991 ITFQSGIARLMIREAFAE-DSGRFTCSAVNEAG---TVSTSCYLAVQVS 1035 Score = 33.5 bits (75), Expect = 1.00 Identities = 28/103 (27%), Positives = 42/103 (40%), Gaps = 11/103 (10%) Query: 559 VTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS-----SAP 613 V +PV+ P L + + G+ + L C P + W Y ED + SS + Sbjct: 936 VEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTW-YREDYQIESSIDFQITFQ 994 Query: 614 SGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656 SG AE SG ++C A N + T+S S + V Sbjct: 995 SGIARLMIREAFAEDSGRFTCSAVN-----EAGTVSTSCYLAV 1032 Score = 33.1 bits (74), Expect = 1.3 Identities = 34/116 (29%), Positives = 50/116 (43%), Gaps = 9/116 (7%) Query: 439 TAEHSGNYYCTADNGFGPQRSKAVSLSVTV-PVSHPVLTLSSAEALTFEGATVTLHCEVQ 497 T + SG Y T N P KAV ++V V PV L ++ +T V+ Sbjct: 18669 TRDDSGKYSLTLVN---PAGEKAVFVNVRVLDTPGPVSDLKVSD-VTKTSCHVSWAPPEN 18724 Query: 498 RGSPQILYQFYHE---DMPLWSSSTPSVGRVSFSF-SLTEGHSGNYYCTADNGFGP 549 G Q+ + + D WS+ TP V + SF +L G+ + TA N +GP Sbjct: 18725 DGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGP 18780 Score = 32.3 bits (72), Expect = 2.2 Identities = 35/161 (21%), Positives = 63/161 (39%), Gaps = 19/161 (11%) Query: 94 SPVHLDFSSASLILQAP-LSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL--------AF 144 +PV + + +L+ ++V EG+SV L C + T Y+ D + F Sbjct: 934 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993 Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISG 204 + I A +D+G + C+ E+ +S + +QV E F + + Sbjct: 994 QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE------ 1047 Query: 205 NPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNF 245 T E + +E DV + ++Q G G +P F Sbjct: 1048 ---KFTTEEKRFVESRDVVMTDTSLTEEQA-GPGEPAAPYF 1084 Score = 31.6 bits (70), Expect = 3.8 Identities = 37/139 (26%), Positives = 51/139 (36%), Gaps = 17/139 (12%) Query: 338 GASISFS----------LTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSP 387 G ISFS +T NSG Y A NG G S A L V + P Sbjct: 53 GVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTA-ELLVKAETAPPNFVQRLQ 111 Query: 388 EDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLT-----AEH 442 + +G++V L P++ +F+ +GA ++ +SL E Sbjct: 112 SMTVRQGSQVRLQVRVTGIPTPVV-KFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPED 170 Query: 443 SGNYYCTADNGFGPQRSKA 461 SG Y A N G S A Sbjct: 171 SGTYSVNATNSVGRATSTA 189 Score = 31.6 bits (70), Expect = 3.8 Identities = 27/119 (22%), Positives = 49/119 (41%), Gaps = 12/119 (10%) Query: 99 DFSSASLILQAPLS--VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRT------- 149 + S A + P S + EG +V+ C E + +KN+ ++ + + Sbjct: 33129 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNV 33188 Query: 150 -DFHIPHACLKDNGAY--RCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGN 205 I +A + D+G Y + ++ C +S V V+EP VLR S + G+ Sbjct: 33189 YSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGS 33247 Score = 30.4 bits (67), Expect = 8.5 Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 8/104 (7%) Query: 635 EANNGLVAQHSDT--ISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW 692 E +G A+ ++T + V +PV+ P L + G+ + L C SP + W Sbjct: 917 EVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTW 976 Query: 693 FYHEDVTLG-----KISAPSGGGASFNLSLTTEHSGIYSCEADN 731 Y ED + +I+ SG E SG ++C A N Sbjct: 977 -YREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVN 1019 Score = 30.4 bits (67), Expect = 8.5 Identities = 64/295 (21%), Positives = 99/295 (33%), Gaps = 31/295 (10%) Query: 283 PASHPVLTLSPE---------KALNFEGTKVTLHCETQE-DSLRTLYRF---YHEGVPLR 329 PAS PV+ P + L+ VTL E E D + + + Y + Sbjct: 30417 PASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSA 30476 Query: 330 HKSVRCERGASISFSL-----TTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH-PVLN 383 K ER F++ TE + + GL A+S+ + P + Sbjct: 30477 WKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIR 30536 Query: 384 LSSPEDLIFEGAKVTLHCEAQRGSLPIL--YQFHHEGAALERRSANSAGGVAISFSLTAE 441 + G L C+ LP + Y+F E + +S G +T E Sbjct: 30537 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE 30596 Query: 442 HS--GNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRG 499 G Y C A N G + + L P HP L + G+T+ LH + G Sbjct: 30597 QEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKE-KYYGAVGSTLRLHV-MYIG 30654 Query: 500 SPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLT------EGHSGNYYCTADNGFG 548 P ++H L +S ++ L + H+G Y N FG Sbjct: 30655 RPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFG 30709 >gi|50511926 Fc fragment of IgG, low affinity IIb, receptor isoform 3 [Homo sapiens] Length = 291 Score = 112 bits (280), Expect = 2e-24 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 8/198 (4%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L LAPV+G A P+ ++ L+P W V Q + VTLTC+G +W+H Sbjct: 28 MLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 87 Query: 61 YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116 G I T + +SGEY CQ + LS PVHL S L+LQ P L EG Sbjct: 88 --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 145 Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175 +++VLRC + K + + T ++N F +F IP A +G Y CTG Sbjct: 146 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 204 Query: 176 VSSNTVKIQVQEPFTRPV 193 SS V I VQ P + P+ Sbjct: 205 YSSKPVTITVQAPSSSPM 222 Score = 49.7 bits (117), Expect = 1e-05 Identities = 46/194 (23%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 283 PASHP--VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340 PA+ P VL L P+ + VTL C +++H G + S Sbjct: 44 PAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPS 98 Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400 F +SG Y C + P LS + + P L EG + L Sbjct: 99 YRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLR 151 Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460 C + + + F G + ++ + S +I HSG+Y+CT + G+ SK Sbjct: 152 CHSWKDKPLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSK 208 Query: 461 AVSLSVTVPVSHPV 474 V+++V P S P+ Sbjct: 209 PVTITVQAPSSSPM 222 Score = 48.9 bits (115), Expect = 2e-05 Identities = 50/217 (23%), Positives = 83/217 (38%), Gaps = 23/217 (10%) Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732 D + L C S + WF++ ++ P+ S+ SG Y+C+ Sbjct: 65 DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 116 Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 + S+ V L V L L+ P G+ + L C + + PL+ FF Sbjct: 117 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 168 Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849 +S + N S+ HSG+Y C + G S+ VT+ + +++ G Sbjct: 169 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 225 Query: 850 TGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPA 886 V G+ A +AA L+YC R + D A Sbjct: 226 VAVVTGIAVAAIVAAVVALIYCRKKRISANPTNPDEA 262 Score = 45.4 bits (106), Expect = 3e-04 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%) Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440 VL L + + VTL C Q+ H G + + S F Sbjct: 51 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 105 Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500 SG Y C ++S V + V L L + EG T+ L C + Sbjct: 106 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 158 Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557 P + F+ + + R +FS+ + HSG+Y+CT + G+ S+ V++ Sbjct: 159 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 212 Query: 558 FVTVPVSRPI 567 V P S P+ Sbjct: 213 TVQAPSSSPM 222 Score = 44.3 bits (103), Expect = 6e-04 Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 18/174 (10%) Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656 + WF++ ++ P+ + S+ SG Y+C+ + SD + L+V+ Sbjct: 82 IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 129 Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716 L + P + G+ + L C + + + F+ GK S +F++ Sbjct: 130 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 184 Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLL 769 HSG Y C + G S+ VT+ V P S P+ + A T AV ++ Sbjct: 185 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIV 238 >gi|50511930 Fc fragment of IgG, low affinity IIb, receptor isoform 1 [Homo sapiens] Length = 310 Score = 112 bits (280), Expect = 2e-24 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 8/198 (4%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L LAPV+G A P+ ++ L+P W V Q + VTLTC+G +W+H Sbjct: 28 MLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 87 Query: 61 YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116 G I T + +SGEY CQ + LS PVHL S L+LQ P L EG Sbjct: 88 --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 145 Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175 +++VLRC + K + + T ++N F +F IP A +G Y CTG Sbjct: 146 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 204 Query: 176 VSSNTVKIQVQEPFTRPV 193 SS V I VQ P + P+ Sbjct: 205 YSSKPVTITVQAPSSSPM 222 Score = 49.7 bits (117), Expect = 1e-05 Identities = 46/194 (23%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 283 PASHP--VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340 PA+ P VL L P+ + VTL C +++H G + S Sbjct: 44 PAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPS 98 Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400 F +SG Y C + P LS + + P L EG + L Sbjct: 99 YRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLR 151 Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460 C + + + F G + ++ + S +I HSG+Y+CT + G+ SK Sbjct: 152 CHSWKDKPLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSK 208 Query: 461 AVSLSVTVPVSHPV 474 V+++V P S P+ Sbjct: 209 PVTITVQAPSSSPM 222 Score = 48.1 bits (113), Expect = 4e-05 Identities = 47/202 (23%), Positives = 79/202 (39%), Gaps = 23/202 (11%) Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732 D + L C S + WF++ ++ P+ S+ SG Y+C+ Sbjct: 65 DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 116 Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 + S+ V L V L L+ P G+ + L C + + PL+ FF Sbjct: 117 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 168 Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849 +S + N S+ HSG+Y C + G S+ VT+ + +++ G Sbjct: 169 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 225 Query: 850 TGVAGGLLSIAGLAAGALLLYC 871 V G+ A +AA L+YC Sbjct: 226 VAVVTGIAVAAIVAAVVALIYC 247 Score = 45.4 bits (106), Expect = 3e-04 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%) Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440 VL L + + VTL C Q+ H G + + S F Sbjct: 51 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 105 Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500 SG Y C ++S V + V L L + EG T+ L C + Sbjct: 106 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 158 Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557 P + F+ + + R +FS+ + HSG+Y+CT + G+ S+ V++ Sbjct: 159 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 212 Query: 558 FVTVPVSRPI 567 V P S P+ Sbjct: 213 TVQAPSSSPM 222 Score = 44.7 bits (104), Expect = 4e-04 Identities = 43/191 (22%), Positives = 77/191 (40%), Gaps = 23/191 (12%) Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656 + WF++ ++ P+ + S+ SG Y+C+ + SD + L+V+ Sbjct: 82 IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 129 Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716 L + P + G+ + L C + + + F+ GK S +F++ Sbjct: 130 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 184 Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLE----- 770 HSG Y C + G S+ VT+ V P S P+ + A T AV ++ Sbjct: 185 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVAL 244 Query: 771 LHCEALRGSPL 781 ++C R S L Sbjct: 245 IYCRKKRISAL 255 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 112 bits (279), Expect = 2e-24 Identities = 205/866 (23%), Positives = 337/866 (38%), Gaps = 99/866 (11%) Query: 21 PRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYH-----RYLGKEILRETPDNIL 75 P P+I + P TV GER LTC T W R +R + L Sbjct: 519 PPPVIQV-PNNVTVTPGERAVLTCLIISAVDYNLT-WQRNDRDVRLAEPARIRTLANLSL 576 Query: 76 EVQ-----ESGEYRCQ--AQGSPLSSPVHLDFSSASLILQAPL--SVFEGDSVVLRCRA- 125 E++ ++GEY C ++G ++ V L + P S G V + C A Sbjct: 577 ELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSAT 636 Query: 126 -----KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT 180 K T+N+ + + T F I +A KD G Y C + ++T Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDGTLF-IKNAAPKDAGIYGCLASNSAGTDKQNST 695 Query: 181 VKIQVQEPFTRPVLRASSFQPISGNPVTLTCET------QLSLERSDVPLR-FRFFRDDQ 233 ++ ++ P + ++ S G+ + C+T Q+ + D+ LR F D Sbjct: 696 LRY-IEAP--KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDP 752 Query: 234 TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293 LGL +I D+G Y C A I+++ R+ ++ + P + + Sbjct: 753 LLGL-------LKIQETQDLDAGDYTCVA-------INEAGRATGKITLDVGSPPVFIQE 798 Query: 294 EKALNFE-GTKVTLHCETQEDSLRTLYRFYHEGVPL--RHKSV----RCERGASISFSLT 346 ++ E G+ VTL C Q T+ + +P+ R SV + GA +L Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLW 858 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406 + G Y C A+N G K +++VT V+ P++ +S + EG ++TL C G Sbjct: 859 ASDKGTYICEAENQFG-KIQSETTVTVTGLVA-PLIGISPSVANVIEGQQLTLPCTLLAG 916 Query: 407 S-LPILYQFHHEGAALERR--SANSAGGVAISFSLTAEHSGNYYCTADNGFGP-QRSKAV 462 + +P + L+ + S G + I + + G Y C A N G ++ +V Sbjct: 917 NPIPERRWIKNSAMLLQNPYITVRSDGSLHIE-RVQLQDGGEYTCVASNVAGTNNKTTSV 975 Query: 463 SLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV 522 + V + H LS T EG VTL C+ + ++ SS+ S Sbjct: 976 VVHVLPTIQHGQQILS-----TIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSA 1030 Query: 523 GRVSFSFSLTEG--HSGNYYCTADNGFGPQRSEV-VSLFVTVPV---SRPILTLRVPRAQ 576 G + ++ G SG Y CTA N G + +V ++++V V R + + Sbjct: 1031 GADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS 1090 Query: 577 AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-----SGGEASFNLSLTAEHSGN 631 + G+ + L CE PPI+ W ++ L S +P G + T++ SG Sbjct: 1091 VLAGEEVTLPCEVKSLPPPIITW--AKETQLISPFSPRHTFLPSGSMKITETRTSD-SGM 1147 Query: 632 YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILY 691 Y C A N + + + L+V VP P + + VG +++ C A P++ Sbjct: 1148 YLCVATN-IAGNVTQAVKLNVHVP---PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVIT 1203 Query: 692 WFYHEDVTL--GKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPV 749 W L G+ + G T +GIY+C A N +E +TL V P Sbjct: 1204 WSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPP 1262 Query: 750 SRPVLTLRAPGT----HAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PS 800 + V L P +E C A +G+P ++ H L R Sbjct: 1263 T--VEDLEPPYNTTFQERVANQRIEFPCPA-KGTPKPTIKWLHNGRELTGREPGISILED 1319 Query: 801 GGASLNLSLTAEHSGNYSCEADNGLG 826 G + S+T +G Y C A N G Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAG 1345 Score = 102 bits (253), Expect = 2e-21 Identities = 188/815 (23%), Positives = 316/815 (38%), Gaps = 101/815 (12%) Query: 77 VQESGEYRCQAQGSPLS--SPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVTLN 132 + + G Y C A S + + D S ++Q P ++V G+ VL C + V N Sbjct: 491 LSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYN 550 Query: 133 NTIYKNDNVLAFLNK-------RTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQV 185 T +ND + + D G Y C E +S V + V Sbjct: 551 LTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAAS--VFLTV 608 Query: 186 QEPFTRPVL-RASSFQPISGNPVTLTCET------QLSLERSDVPL----RFRFFRDDQT 234 QEP V+ + SF G+ V++ C +++ +D+ + R+R D Sbjct: 609 QEPPKVTVMPKNQSFT--GGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTL 666 Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294 I KD+G Y C A+ + +S +I+ P L + Sbjct: 667 F-----------IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEA------PKLMVVQS 709 Query: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKS---VRCERGASISFSLTTENSG 351 + L G + C+T + +++ + LR + + G ++G Sbjct: 710 ELLVALGDITVMECKTSGIPPPQV-KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAG 768 Query: 352 NYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE-GAKVTLHCEAQRGSLPI 410 +Y C A N G K +T+ V P + + P D+ E G+ VTL C Q P Sbjct: 769 DYTCVAINEAGRATGK-----ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPT 823 Query: 411 LYQFHHEGAALERRSANSAG------GVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464 + + + R + + G +L A G Y C A+N FG +S+ ++ Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSE-TTV 882 Query: 465 SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS---STPS 521 +VT V+ P++ +S + A EG +TL C + G+P ++ L + + S Sbjct: 883 TVTGLVA-PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS 941 Query: 522 VGRVSFS-FSLTEGHSGNYYCTADNGFGPQR---SEVVSLFVTVPVSRPILTLRVPRAQA 577 G + L +G G Y C A N G S VV + T+ + IL+ Sbjct: 942 DGSLHIERVQLQDG--GEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILS-------T 992 Query: 578 VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGE--ASFNLSLTAEHSGNYSCE 635 + G + L C+A P + W ++ SS+ S G + + +S E SG Y C Sbjct: 993 IEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCT 1052 Query: 636 ANNGLVAQHSDTISLSVIVPV-----SRPILTFRAPRAQAVVGDLLELHCEALRGSSPIL 690 A N + L+V V R + + + G+ + L CE PI+ Sbjct: 1053 ATN-TAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII 1111 Query: 691 YWFYHEDVTLGKISAPSGGGASFNLSLT---TEHSGIYSCEADNGLEAQRSEMVTLKVAV 747 W E + S S ++ +T T SG+Y C A N + ++ V L V V Sbjct: 1112 TW-AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN-IAGNVTQAVKLNVHV 1169 Query: 748 PVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL-----GNRSSPSGG 802 P P + VG +++ C A +G+PL + + T+ + S+P G Sbjct: 1170 P---PKIQRGPKHLKVQVGQRVDIPCNA-QGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225 Query: 803 ASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYI 837 S++ T +G Y+C A N G +E +TL++ Sbjct: 1226 LSID-QATPSDAGIYTCVATNIAGTDETE-ITLHV 1258 Score = 99.0 bits (245), Expect = 2e-20 Identities = 209/867 (24%), Positives = 325/867 (37%), Gaps = 116/867 (13%) Query: 28 QPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPD------------NIL 75 +P TV + +VTL CK P T W E L+ TP N Sbjct: 3627 EPRDITVLRNRQVTLECKSDAVPPPVIT-WLRN---GERLQATPRVRILSGGRYLQINNA 3682 Query: 76 EVQESGEYRCQAQGSP----------LSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA 125 ++ ++ Y C A ++ P ++ SL+ + S VL C A Sbjct: 3683 DLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLV------ILLNKSTVLECIA 3736 Query: 126 KAEVTLNNTIYKNDNVLAFLNKRTDF------HIPHACLKDNGAYRCTGYKESCCPVSSN 179 + T T K+ VLA + R HI A + D G Y C + Sbjct: 3737 EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMA--TNAAGTDRR 3794 Query: 180 TVKIQVQEPFTRPVLRASSFQPISGN-PVTLTCETQLSLERSDVPLRFRFFR-------- 230 + +QV P S P N V + +T L+ E + +P +R Sbjct: 3795 RIDLQVHVP--------PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNV 3846 Query: 231 DDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290 D S + I + D+ Y C T+ D + VQ+P P + Sbjct: 3847 DQNQNSYRLLSSGSLVIISPSVDDTATYEC---TVTNGAGDDKRTVDLTVQVP---PSIA 3900 Query: 291 LSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL--RHKSVRCERGASISFSLTTE 348 P L + + C +++ + G+ L R R +I T Sbjct: 3901 DEPTDFLVTKHAPAVITCTASGVPFPSIH-WTKNGIRLLPRGDGYRILSSGAIEILATQL 3959 Query: 349 N-SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 N +G Y C A N G+ + V+L V P PV+ E + + L CEA Sbjct: 3960 NHAGRYTCVARNAAGSA-HRHVTLHVHEP---PVIQPQPSELHVILNNPILLPCEATGTP 4015 Query: 408 LPILYQFHHEGAALERRSANSA----GGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVS 463 P + + EG + N A GG+ IS ++ E +G Y C A N G K + Sbjct: 4016 SPFI-TWQKEGINVNTSGRNHAVLPSGGLQISRAVR-EDAGTYMCVAQNPAGTALGK-IK 4072 Query: 464 LSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV- 522 L+V VP PV++ E + +TL CE G P ++ + + S V Sbjct: 4073 LNVQVP---PVISPHLKEYVIAVDKPITLSCEAD-GLPPPDITWHKDGRAIVESIRQRVL 4128 Query: 523 --GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVG 580 G + +F + G +G+Y C A N G S L V VP +R V Sbjct: 4129 SSGSLQIAF-VQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPR-----IRSTEGHYTVN 4181 Query: 581 DLLE--LHCEAPRGSPPILYWFYHEDVT---LGSSSAPSGGEASFNLSLTAEHSGNYSCE 635 + + L C A P + W + LG +A GE ++ E SG Y+C Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILE-NVVLEDSGFYTCV 4240 Query: 636 ANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYH 695 ANN + + T+SL+V V P T G+ L L C+A P L W ++ Sbjct: 4241 ANNA-AGEDTHTVSLTVHV---LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFN 4296 Query: 696 EDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSR---P 752 ++ + +G ++ E SG Y C A+N + ++ PV + P Sbjct: 4297 NNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYP 4356 Query: 753 VLTLRAPGTHAAVGDLLELHCEALRG--SPLILYRFFHEDVTLGNRSSPSGGASLNLSLT 810 + G +A L+CE ++G +P I + D+ + +R G SL + T Sbjct: 4357 SNWIEPLGGNAI------LNCE-VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGT 4409 Query: 811 A-EHSGNYSCEADNGLG-AQRSETVTL 835 E +G+Y+C A N G +RS ++TL Sbjct: 4410 VNEDAGDYTCVATNEAGVVERSMSLTL 4436 Score = 84.7 bits (208), Expect = 4e-16 Identities = 190/869 (21%), Positives = 329/869 (37%), Gaps = 104/869 (11%) Query: 23 PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR---YLGKEILRETPDNIL---- 75 P+I + P V +G+++TL C + +W L + D L Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIER 949 Query: 76 -EVQESGEYRCQAQGSPLSSPVHLDFSSASLIL---------QAPLSVFEGDSVVLRCRA 125 ++Q+ GEY C A S+ + + S+++ Q LS EG V L C+A Sbjct: 950 VQLQDGGEYTCVA-----SNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKA 1004 Query: 126 KAEVTLNNTIYKNDNVLAFLNKR------TDFHIPHACLKDNGAYRCTGYKESCCPVSSN 179 + K +++ + + ++ +++G Y CT + Sbjct: 1005 SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKV 1064 Query: 180 TVKIQVQEPFTRPVLRASSFQPI-----SGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 + + V+ S +P+ +G VTL CE +S P + ++ Q Sbjct: 1065 QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV-----KSLPPPIITWAKETQL 1119 Query: 235 LG-----LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVL 289 + + S + +IT + DSG Y C A + +V + + V +P P + Sbjct: 1120 ISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV---TQAVKLNVHVP---PKI 1173 Query: 290 TLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG-----VPLRHKSVRCERGASISFS 344 P+ G +V + C Q L + + +G V H + SI Sbjct: 1174 QRGPKHLKVQVGQRVDIPCNAQGTPLPVI--TWSKGGSTMLVDGEHHVSNPDGTLSID-Q 1230 Query: 345 LTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE----GAKVTLH 400 T ++G Y C A N G ++ ++L V P + V +L P + F+ ++ Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPT--VEDLEPPYNTTFQERVANQRIEFP 1287 Query: 401 CEAQRGSLPILYQFHHEGAALERR----SANSAGGVAISFSLTAEHSGNYYCTADNGFGP 456 C A+ P + ++ H G L R S G + + S+T +G Y C A N G Sbjct: 1288 CPAKGTPKPTI-KWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346 Query: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALT----FEGATVTLHCEVQRGSPQILYQFYHEDM 512 K +L V VP PV + E +T L CEV+ G+P + +Y +++ Sbjct: 1347 TERK-YNLKVHVP---PV--IKDKEQVTNVSVLLNQLTNLFCEVE-GTPSPIIMWYKDNV 1399 Query: 513 PLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILT 569 + SST G++ F T +G Y C A N G + + ++ V VP + I+ Sbjct: 1400 QVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ-KYFNIDVLVPPT--IIG 1456 Query: 570 LRVPRAQAVVGDL-LELHCEAPRGSP-PILYWFYH-EDVTLGSSSAP--SGGEASFNLSL 624 P +VV + + L C+ +G+P P ++WF + + LG + G+ + Sbjct: 1457 TNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNA 1515 Query: 625 TAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALR 684 G Y C +N Q D I L++ +P S ++ L++L CE Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKD-IKLTIYIPPSIKGGNVTTD-ISVLINSLIKLECETRG 1573 Query: 685 GSSPILYWFYHEDVTLGKISA--PSGGGASFNLSLTTEHSGIYSCEADN-GLEAQRSEMV 741 P + W+ + A G S Y+C N A++S V Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633 Query: 742 TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL---GNRSS 798 + V + + T + L L C+A G+P + + + V + N Sbjct: 1634 DVYVPPMIEGNLAT--PLNKQVVIAHSLTLECKA-AGNPSPILTWLKDGVPVKANDNIRI 1690 Query: 799 PSGGASLNLSLTAE-HSGNYSCEADNGLG 826 +GG L + E G Y C A + G Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAG 1719 Score = 83.2 bits (204), Expect = 1e-15 Identities = 182/818 (22%), Positives = 301/818 (36%), Gaps = 95/818 (11%) Query: 78 QESGEYRCQAQGSP------------LSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA 125 +ESGEY C A + + V D S +SV G+ V L C Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103 Query: 126 KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLK-------DNGAYRCTGYKESCCPVSS 178 K+ T K +++ + R F +P +K D+G Y C + + Sbjct: 1104 KSLPPPIITWAKETQLISPFSPRHTF-LPSGSMKITETRTSDSGMYLCVA--TNIAGNVT 1160 Query: 179 NTVKIQVQEPFTRPVLRASSFQPIS-GNPVTLTCETQLSLERSDVPLRFRFFRDDQTL-- 235 VK+ V P + R + G V + C Q + +P+ + + T+ Sbjct: 1161 QAVKLNVHVP--PKIQRGPKHLKVQVGQRVDIPCNAQ----GTPLPV-ITWSKGGSTMLV 1213 Query: 236 -GLGWSLSPN--FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLS 292 G +P+ I D+G Y C A + + D + VQ P + V L Sbjct: 1214 DGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT---DETEITLHVQEPPT--VEDLE 1268 Query: 293 PEKALNFE----GTKVTLHCETQEDSLRTLYRFYHEGVPLRHK----SVRCERGASISFS 344 P F+ ++ C + T+ ++ H G L + S+ + + S Sbjct: 1269 PPYNTTFQERVANQRIEFPCPAKGTPKPTI-KWLHNGRELTGREPGISILEDGTLLVIAS 1327 Query: 345 LTTENSGNYYCTADNGLGAKPSKAVSLSVTVPV----SHPVLNLSSPEDLIFEGAKVTLH 400 +T ++G Y C A N G K +L V VP V N+S + L Sbjct: 1328 VTPYDNGEYICVAVNEAGTTERK-YNLKVHVPPVIKDKEQVTNVS-----VLLNQLTNLF 1381 Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSA--GGVAISFSLTAEHSGNYYCTADNGFGPQR 458 CE + PI+ + E + + G + F T E +G Y C A N G + Sbjct: 1382 CEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ 1441 Query: 459 SKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS 518 K ++ V VP + + T E V L C+V +G+P ++ + PL+ Sbjct: 1442 -KYFNIDVLVPPTI-IGTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPLFLGD 1498 Query: 519 TPSV-----GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572 P+V G+V + G Y CT N G Q ++ +++++ + +T + Sbjct: 1499 -PNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDI 1557 Query: 573 PRAQAVVGDLLELHCEAPRGSP-PILYWFYHEDVTLGSSSAP--SGGEASFNLSLTAEHS 629 ++ L++L CE RG P P + W+ + SS A G+ S Sbjct: 1558 ---SVLINSLIKLECET-RGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDS 1613 Query: 630 GNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPI 689 Y+C N + + + V VP Q V+ L L C+A SPI Sbjct: 1614 ATYTCHVAN-VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI 1672 Query: 690 LYWFYHEDVTL---GKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746 L W + V + I +GG +S G Y C A + ++ + V Sbjct: 1673 LTWL-KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA-TSVAGEKEIKYEVDVL 1730 Query: 747 VPVSRPVLTLRAPGTH--AAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS----PS 800 VP P + ++ V +LLEL C + GSP + + + R + Sbjct: 1731 VP---PAIEGGDETSYFIVMVNNLLELDCH-VTGSPPPTIMWLKDGQLIDERDGFKILLN 1786 Query: 801 GGASLNLSLTAEHSGNYSCEADNGLGAQRSE-TVTLYI 837 G + ++G Y C A N G + E VT+++ Sbjct: 1787 GRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHV 1824 Score = 79.0 bits (193), Expect = 2e-14 Identities = 168/822 (20%), Positives = 306/822 (37%), Gaps = 94/822 (11%) Query: 65 EILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP----------LSVF 114 ++ R TP+ ++G Y C+A +S + + +L P +SV Sbjct: 1417 KLFRATPE------DAGRYSCKAINIAGTSQKYFNID----VLVPPTIIGTNFPNEVSVV 1466 Query: 115 EGDSVVLRCRAKAEVTLN-------NTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCT 167 V L C+ K + ++ D + L++ H+ +A D G Y+CT Sbjct: 1467 LNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCT 1526 Query: 168 GYKESCCPVSSNTVKIQVQEPFTRPVLRASS----FQPISGNPVTLTCETQLSLERSDVP 223 + + +K+ + P P ++ + + + + L CET+ +P Sbjct: 1527 --VSNAAGKQAKDIKLTIYIP---PSIKGGNVTTDISVLINSLIKLECETR------GLP 1575 Query: 224 L-RFRFFRDDQTL-----GLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW 277 + +++D Q + L I DS Y C A +V + +S+ Sbjct: 1576 MPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVA----NVAGTAEKSF 1631 Query: 278 -IQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRC 335 + V +P +P +TL C+ + L + +GVP++ + ++R Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL-TWLKDGVPVKANDNIRI 1690 Query: 336 ERGASISFSLTTE--NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPED--LI 391 E G ++ + + G Y C A + G K K + V VP P + ++ Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK-YEVDVLVP---PAIEGGDETSYFIV 1746 Query: 392 FEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSA---GGVAISFSLTAEHSGNYYC 448 + L C GS P + +G ++ R G + ++G Y C Sbjct: 1747 MVNNLLELDCHVT-GSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRC 1805 Query: 449 TADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFY 508 A N G + + VTV V + + +E + + V L C + G P + Sbjct: 1806 MAANTAGDHKKE---FEVTVHVPPTIKSSGLSERVVVKYKPVALQC-IANGIPNPSITWL 1861 Query: 509 HEDMPLWSSS----TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVS 564 +D P+ ++ S GRV +G Y C A N G + + + L V P S Sbjct: 1862 KDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAG-ETQQHIQLHVHEPPS 1920 Query: 565 RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP--SGGEASFNL 622 ++ +V + ++L C+A P++ W+ + GS+S + G+ Sbjct: 1921 LEDAG-KMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIE 1979 Query: 623 SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 S +G Y C A N A + S+ V V+ P ++ VV + + L CEA Sbjct: 1980 SAQISDAGIYKCVAINSAGATE---LFYSLQVHVA-PSISGSNNMVAVVVNNPVRLECEA 2035 Query: 683 LRGSSPILYWFYHEDVT---LGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSE 739 +P L W + SGG S +G Y+C A N ++ Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNA-AGEKQR 2094 Query: 740 MVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHC--EALRGSPLILYRFFHEDVTLGNRS 797 + L+V VP P + + +EL C +A+ L + H + S Sbjct: 2095 DIDLRVYVP---PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLS 2151 Query: 798 SPSGGASLNL-SLTAEHSGNYSCEADNGLG-AQRSETVTLYI 837 + L + + +G Y+CEA N G +++ V +++ Sbjct: 2152 ISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWV 2193 Score = 78.6 bits (192), Expect = 3e-14 Identities = 144/643 (22%), Positives = 240/643 (37%), Gaps = 56/643 (8%) Query: 222 VPLRFRFFRDDQTLG----LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW 277 +P F R+ TLG L S S N I + D GFY C A + S + +++ Sbjct: 457 LPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVS---SAGTGRAQTF 513 Query: 278 IQVQIPASHPVLTLSPEKALNFEGTKVTLHC--ETQEDSLRTLYRFYHEGVPLRHKSVRC 335 V P P + P G + L C + D T R + +R Sbjct: 514 FDVSEP---PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRT 570 Query: 336 ERGASISF-SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEG 394 S+ S+ ++G Y+C + G + +V L+V P P + + G Sbjct: 571 LANLSLELKSVKFNDAGEYHCMVSSE-GGSSAASVFLTVQEP---PKVTVMPKNQSFTGG 626 Query: 395 AKVTLHCEAQRGSLP-ILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNG 453 ++V++ C A P I + + R ++ G + + +G Y C A N Sbjct: 627 SEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNS 686 Query: 454 FGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP 513 G + S + P L + +E L G + C+ G P +++ D+ Sbjct: 687 AGTDKQN----STLRYIEAPKLMVVQSELLVALGDITVMECKTS-GIPPPQVKWFKGDLE 741 Query: 514 LWSSS----TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILT 569 L S+ P +G + + +G+Y C A N G + +T+ V P + Sbjct: 742 LRPSTFLIIDPLLGLLKIQ-ETQDLDAGDYTCVAINEAGRATGK-----ITLDVGSPPVF 795 Query: 570 LRVPRAQAV-VGDLLELHCEAPRGSPPILYW-------FYHEDVTLGSSSAPSGGEASFN 621 ++ P ++ +G + L C P + W + ++ S S G A F Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG-ALFI 854 Query: 622 LSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681 L+L A G Y CEA N S+T + + P++ A + G L L C Sbjct: 855 LNLWASDKGTYICEAENQFGKIQSET--TVTVTGLVAPLIGISPSVANVIEGQQLTLPCT 912 Query: 682 ALRGSS-PILYWFYHEDVTLGK--ISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738 L G+ P W + + L I+ S G + + G Y+C A N + Sbjct: 913 LLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIE-RVQLQDGGEYTCVASN---VAGT 968 Query: 739 EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEAL-RGSPLILYRFFHEDVTLGNRS 797 T V V V P + G + L C+A P +++ E ++ + Sbjct: 969 NNKTTSVVVHV-LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAK 1027 Query: 798 SPSG--GASLNLSLTAEHSGNYSCEADNGLG-AQRSETVTLYI 837 +G G+ +S E SG Y C A N G A+R +T+Y+ Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYV 1070 Score = 76.6 bits (187), Expect = 1e-13 Identities = 179/784 (22%), Positives = 292/784 (37%), Gaps = 92/784 (11%) Query: 113 VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRC 166 V G S+ L C + T K+ + L L++ + + + D G Y C Sbjct: 2304 VTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVC 2363 Query: 167 TGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-R 225 + + + + + N V+LTCE S +PL Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA------SGIPLPS 2417 Query: 226 FRFFRDDQTLGLGWS---LSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWIQV 280 +F+D + L S LS + M + +D+G Y C + + + V Sbjct: 2418 ITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRN---AAGEERKIFGLSV 2474 Query: 281 QIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR----HKSVRCE 336 +P H V + E E VTL CE + + + ++ +G PL+ H + Sbjct: 2475 LVPP-HIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEI-TWHKDGQPLQEDEAHHIISGG 2532 Query: 337 RGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTV-PVSHPVLNLSSPEDL-IFEG 394 R I+ ++ ++G Y C A + G K S++ SL+V V P V + +PED+ + Sbjct: 2533 RFLQIT-NVQVPHTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590 Query: 395 AKVTLHCEAQRGSLPILYQFHHEGAALE--RRSANSAGGVAISF-SLTAEHSGNYYCTAD 451 + +L CEA P + +G LE R GG + + +++G Y C A Sbjct: 2591 SPTSLVCEAYSYP-PATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVAT 2649 Query: 452 NGFGPQRSKAVSLSVTVPVSHPVLT--------LSSAEALTFEGATVTLHCEVQRGSPQI 503 N G + K + V +P P++ LS E T+TL CE P Sbjct: 2650 NEAG-EMIKHYEVKVYIP---PIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY-AIPSA 2704 Query: 504 LYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEVVSLFVT 560 +Y + PL S ++ + + E +G Y C A N G + + + Sbjct: 2705 SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDF-DVNIQ 2763 Query: 561 VPVSRPIL--------TLRVPRAQ-AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS 611 VP S L T R A+ ++ + + L+CE PP L W Y + L SS Sbjct: 2764 VPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW-YKDGHPLTSSD 2822 Query: 612 AP---SGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRA 668 GG E +G Y+C A N + S + V+VP P Sbjct: 2823 KVLILPGGRVLQIPRAKVEDAGRYTCVAVNE-AGEDSLQYDVRVLVPPIIKGANSDLPEE 2881 Query: 669 QAVVG------DLLELHCEALRGS-----SPILYWFYHEDVTLGKISAPSGGGASFNLSL 717 V+ + L A R S P+L +H+ ++ G+I N + Sbjct: 2882 VTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRIL------QILNTQI 2935 Query: 718 TTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALR 777 T G Y C A+N + L V VP S V+ ++ V + + L CE Sbjct: 2936 T--DIGRYVCVAEN-TAGSAKKYFNLNVHVPPS--VIGPKSENLTVVVNNFISLTCEVSG 2990 Query: 778 GSPLILYRFFHEDVTLGNRSS---PSGGASLNLSLTAEHSGNYSCEADNGLGAQRSE-TV 833 P L +E N ++ P G + G Y+C A N G + + ++ Sbjct: 2991 FPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSL 3050 Query: 834 TLYI 837 T+Y+ Sbjct: 3051 TVYV 3054 Score = 75.1 bits (183), Expect = 3e-13 Identities = 157/707 (22%), Positives = 260/707 (36%), Gaps = 86/707 (12%) Query: 202 ISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSL-----SPNFQITAMWSKDSG 256 I +P +L CE S P +F+D L ++ QI ++G Sbjct: 2588 ILNSPTSLVCEAY-----SYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAG 2642 Query: 257 FYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT--------LSPEKALNFEGTKVTLHC 308 Y C A +I ++V IP P++ LSP++ +TL C Sbjct: 2643 RYSCVATNEAGEMIKHYE---VKVYIP---PIINKGDLWGPGLSPKEVKIKVNNTLTLEC 2696 Query: 309 ETQEDSLRTLYRFYHEGVPLR---HKSVRCERGASISFSLTTENSGNYYCTADNGLGAKP 365 E +L +Y +G PL+ H ++ ++G Y C A N + + Sbjct: 2697 EAYAIPSASL-SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASN-IAGED 2754 Query: 366 SKAVSLSVTVPVSHPVL----------NLSSPEDLIFEGAKVTLHCEAQRGSLPIL--YQ 413 +++ VP S L +D+I ++L+CE P L Y+ Sbjct: 2755 ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP-ISLYCETNAAPPPTLTWYK 2813 Query: 414 FHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHP 473 H + ++ G V E +G Y C A N G + S + V VP P Sbjct: 2814 DGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG-EDSLQYDVRVLVP---P 2869 Query: 474 VLTLSSA----EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTP---SVGRVS 526 ++ +++ E + + C + GSP + + PL S GR+ Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIEC-LSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRIL 2928 Query: 527 FSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELH 586 + G Y C A+N G + + +L V VP S ++ + VV + + L Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAK-KYFNLNVHVPPS--VIGPKSENLTVVVNNFISLT 2985 Query: 587 CEAPRGSPPILYWFYHED-VTLGSSS-APSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644 CE PP L W +E + L +++ GG + G Y+C A N + Sbjct: 2986 CEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAIN-QAGES 3044 Query: 645 SDTISLSVIVPVSRPILTFRAPRAQAVV----GDLLELHCEALRGSSPILYWFYHEDVTL 700 SL+V VP P + + +VV G + L CE+ P++ W+ + + Sbjct: 3045 KKKFSLTVYVP---PSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMIT 3101 Query: 701 GK--ISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRA 758 + + G +G Y C A N + + + L V VP S + Sbjct: 3102 ESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAGRDDKNFHLNVYVPPS-----IEG 3155 Query: 759 PGTHAAVGDL---LELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLT 810 P V + + L C+A G P + + N S SGG+ L ++ + Sbjct: 3156 PEREVIVETISNPVTLTCDA-TGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARS 3214 Query: 811 A-EHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSGPFATGVAGG 855 SGNY+C A N G AQ+ +++ + A P V G Sbjct: 3215 QHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLG 3261 Score = 73.9 bits (180), Expect = 7e-13 Identities = 148/589 (25%), Positives = 231/589 (39%), Gaps = 60/589 (10%) Query: 40 VTLTCKGFRFYSPQKTKWYHRYL----GKEILRETPDNILEVQ--ESGEYRCQAQGSPLS 93 +T T G F S TK R L G IL IL Q +G Y C A+ + S Sbjct: 3916 ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGS 3975 Query: 94 SPVH--LDFSSASLILQAP--LSVFEGDSVVLRCRA----------KAEVTLNNTIYKND 139 + H L +I P L V + ++L C A + E NT +N Sbjct: 3976 AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNH 4035 Query: 140 NVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSF 199 VL I A +D G Y C + + + +QV P P L+ + Sbjct: 4036 AVLP----SGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVP-PVISPHLK--EY 4088 Query: 200 QPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYW 259 P+TL+CE L D+ +++ S + QI + D+G Y Sbjct: 4089 VIAVDKPITLSCEAD-GLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYT 4147 Query: 260 CKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRT-L 318 C AA + S S + + V +P + + +N E ++ L C D + T Sbjct: 4148 CMAANVAGS---SSTSTKLTVHVPPR--IRSTEGHYTVN-ENSQAILPCVA--DGIPTPA 4199 Query: 319 YRFYHEGVPLRH---KSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTV 375 + + V L + K G I ++ E+SG Y C A+N G + + VSL+V V Sbjct: 4200 INWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVHV 4258 Query: 376 PVSHPVLNLSSPEDL-IFEGAKVTLHCEAQRGSLPIL-YQFHHEGAALERRSANSAGGVA 433 + L P D+ + +G ++ L C+A LP L + F++ S N + Sbjct: 4259 LPTFTEL----PGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELV 4314 Query: 434 ISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLH 493 I ++ E SG Y CTA+N G ++ PV + E L G L+ Sbjct: 4315 IE-RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL---GGNAILN 4370 Query: 494 CEVQRGSPQILYQFYHEDMPLW-SSSTPSVGRVSFS-FSLTEGHSGNYYCTADNGFGP-Q 550 CEV +G P Q+ + + + S +G S + + +G+Y C A N G + Sbjct: 4371 CEV-KGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE 4429 Query: 551 RSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYW 599 RS ++L S PI+TL G + L+C+A P + W Sbjct: 4430 RSMSLTL-----QSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473 Score = 73.6 bits (179), Expect = 9e-13 Identities = 129/555 (23%), Positives = 223/555 (40%), Gaps = 64/555 (11%) Query: 161 NGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRA--SSFQPISGNPVTLTCETQLSLE 218 N A R T + + V + V EP PV++ S I NP+ L CE Sbjct: 3960 NHAGRYTCVARNAAGSAHRHVTLHVHEP---PVIQPQPSELHVILNNPILLPCEA----- 4011 Query: 219 RSDVPLRFRFFRDD----QTLGLGWSLSPN--FQITAMWSKDSGFYWCKAATMPYSVISD 272 + P F ++ + T G ++ P+ QI+ +D+G Y C A + + Sbjct: 4012 -TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG- 4069 Query: 273 SPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKS 332 + + VQ+P PV++ ++ + +TL CE D L +H+ +S Sbjct: 4070 --KIKLNVQVP---PVISPHLKEYVIAVDKPITLSCEA--DGLPPPDITWHKDGRAIVES 4122 Query: 333 VRCERGASISFSLT---TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPED 389 +R +S S + ++G+Y C A N G+ S + L+V VP P + + Sbjct: 4123 IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVP---PRIRSTEGHY 4178 Query: 390 LIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAG-------GVAISFSLTAEH 442 + E ++ L C A P + + + L AN G G I ++ E Sbjct: 4179 TVNENSQAILPCVADGIPTPAI-NWKKDNVLL----ANLLGKYTAEPYGELILENVVLED 4233 Query: 443 SGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQR-GSP 501 SG Y C A+N G + + VSL+V V P T + +G + L C+ P Sbjct: 4234 SGFYTCVANNAAG-EDTHTVSLTVHVL---PTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289 Query: 502 QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTV 561 ++ + F + +P S + +++ SG Y CTA+N G ++ + ++V Sbjct: 4290 KLTWTFNNNIIPAHFDSVNGHSELVIE-RVSKEDSGTYVCTAENSVGFVKA-IGFVYVKE 4347 Query: 562 PVSRPILTLRVPR--AQAVVGDLLELHCEAPRGSPPILYWFYHE-DVTLGSSSAPSGGEA 618 P P+ P + + G+ + L+CE P + W D+ + G + Sbjct: 4348 P---PVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS 4403 Query: 619 SFNLSLTAEHSGNYSCEANNGL-VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLE 677 E +G+Y+C A N V + S +++L S PI+T G + Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQ-----SPPIITLEPVETVINAGGKII 4458 Query: 678 LHCEALRGSSPILYW 692 L+C+A P + W Sbjct: 4459 LNCQATGEPQPTITW 4473 Score = 64.7 bits (156), Expect = 4e-10 Identities = 185/817 (22%), Positives = 296/817 (36%), Gaps = 112/817 (13%) Query: 76 EVQESGEYRCQAQGSPLSS-----------PVHLDFSSASLILQAPLSVFEGDSVVLRCR 124 +V + GEY C A S P D S SL + ++V EG SV L C Sbjct: 3026 KVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV---VNVREGTSVSLECE 3082 Query: 125 AKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSS 178 + A T YKN ++ L HI A + D G Y C + + Sbjct: 3083 SNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKN 3142 Query: 179 NTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLG 238 + + V P R + IS NPVTLTC+ P + ++ + + Sbjct: 3143 FHLNVYVPPSIEGPE-REVIVETIS-NPVTLTCDA-----TGIPPPTIAWLKNHKRIENS 3195 Query: 239 WSL-------SPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQVQIPAS 285 SL QI DSG Y C A+ M Y + P S +IP+ Sbjct: 3196 DSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD 3255 Query: 286 HPVLTLSPEKALNFEGTKVTLHCETQEDSLRT-LYRFYHEGVPLRHKSVRCER----GAS 340 VL G V L C + + T L ++ +G P+ R G++ Sbjct: 3256 VSVLL----------GENVELVCNA--NGIPTPLIQWLKDGKPIASGETERIRVSANGST 3303 Query: 341 IS-FSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399 ++ + T ++G Y C A N G + + +L+V V + + + + + + Sbjct: 3304 LNIYGALTSDTGKYTCVATNPAG-EEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINI 3362 Query: 400 HCEAQRGSLPILYQFHHEGAALERRS---ANSAGGVAISFSLTAEHSGNYYCTADNGFGP 456 C A G+ P + G L S +AG V Y C A N G Sbjct: 3363 ECRA-TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV 3421 Query: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516 +K +L V P + ++ + E +G++ ++ C + G+P + + PL Sbjct: 3422 D-NKHYNLQVFAPPNMD-NSMGTEEITVLKGSSTSMAC-ITDGTPAPSMAWLRDGQPLGL 3478 Query: 517 SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEVVSLFVTVPVSRPIL--TLR 571 + +V L + SG Y C A N G EV F+ + P + + Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG----EVSKHFILKVLEPPHINGSEE 3534 Query: 572 VPRAQAVVGDLLELHCEAPRGSPPILYWF--------YHEDVTLGSSSAPSGGEASFNLS 623 +V + LEL C A P + W + TLG GGE + Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLG------GGEVLRIST 3588 Query: 624 LTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD-LLELHCEA 682 E +G Y+C A++ D V V V I PR V+ + + L C++ Sbjct: 3589 AQVEDTGRYTCLASS---PAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKS 3645 Query: 683 LRGSSPILYWFYHED--VTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740 P++ W + + ++ SGG + + Y+C A N + + + Sbjct: 3646 DAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTRE 3704 Query: 741 VTLKVAVPVS-----RPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGN 795 L V VP + + ++ L T +LE E + +P I +R V GN Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKST------VLECIAEGV-PTPRITWR-KDGAVLAGN 3756 Query: 796 RSSPSGGASLNLSLTAEH---SGNYSCEADNGLGAQR 829 + S + L + + H +G Y C A N G R Sbjct: 3757 HARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793 Score = 60.1 bits (144), Expect = 1e-08 Identities = 120/508 (23%), Positives = 190/508 (37%), Gaps = 42/508 (8%) Query: 344 SLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEA 403 S ++G Y C A N GA + S+ V V+ P ++ S+ + V L CEA Sbjct: 1980 SAQISDAGIYKCVAINSAGATE---LFYSLQVHVA-PSISGSNNMVAVVVNNPVRLECEA 2035 Query: 404 QRGSLPILYQFHHEGAALERRSAN----SAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459 + P L + +G+ + S S G + S +G Y C A N G ++ Sbjct: 2036 RGIPAPSL-TWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG-EKQ 2093 Query: 460 KAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSST 519 + + L V VP P + V L C+ P L + + PL Sbjct: 2094 RDIDLRVYVP---PNIMGEEQNVSVLISQAVELLCQSDAIPPPTL-TWLKDGHPLLKKPG 2149 Query: 520 PSVGRVSFSFSLTEGH---SGNYYCTADNGFGP-QRSEVVSLFVTVPVSRPILTLRVPRA 575 S+ + + +G Y C A N G +++ V+++V + + + + Sbjct: 2150 LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGG---SDELTQL 2206 Query: 576 QAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP----SGGEASFNLSLTAEHSGN 631 + G+L+ L CE+ PP L W L S SGG + Sbjct: 2207 TVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAAL 2266 Query: 632 YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVV---GDLLELHCEALRGSSP 688 YSC A+N + +L V + RP +T ++ G + L CE P Sbjct: 2267 YSCVASN-VAGTAKKEYNLQVYI---RPTITNSGSHPTEIIVTRGKSISLECEVQGIPPP 2322 Query: 689 ILYWFY--HEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746 + W H + + G ++ +G Y C A N + + L V Sbjct: 2323 TVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN-VAGMTDKKYDLSVH 2381 Query: 747 VPVSRPVLTLRAPGTHAAV-GDLLELHCEALRGSPLILYRFFHE--DVTLGNR-SSPSGG 802 P S + R+P + V + + L CEA G PL +F + V+L N SGG Sbjct: 2382 APPS-IIGNHRSPENISVVEKNSVSLTCEA-SGIPLPSITWFKDGWPVSLSNSVRILSGG 2439 Query: 803 ASLNL-SLTAEHSGNYSCEADNGLGAQR 829 L L T E +G Y+C N G +R Sbjct: 2440 RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467 Score = 58.9 bits (141), Expect = 2e-08 Identities = 80/321 (24%), Positives = 131/321 (40%), Gaps = 31/321 (9%) Query: 536 SGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPP 595 +G Y+C + G S S+F+TV P +T+ G + + C A P Sbjct: 586 AGEYHCMVSSEGG---SSAASVFLTVQ-EPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP 641 Query: 596 ILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGLVAQHSDTISLSVIV 654 + W ++ +GS + + + A + +G Y C A+N + S + Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN----STLR 697 Query: 655 PVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGK----ISAPSGGG 710 + P L +GD+ + C+ P + WF D+ L I P G Sbjct: 698 YIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWF-KGDLELRPSTFLIIDPLLGL 756 Query: 711 ASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPG-THAAVGDLL 769 + + +G Y+C A N EA R+ T K+ + V P + ++ P +G + Sbjct: 757 LKIQETQDLD-AGDYTCVAIN--EAGRA---TGKITLDVGSPPVFIQEPADVSMEIGSNV 810 Query: 770 ELHCEALRG--SPLILYR------FFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEA 821 L C ++G P I +R F ++ + S GA L+L A G Y CEA Sbjct: 811 TLPCY-VQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869 Query: 822 DNGLGAQRSETVTLYITGLTA 842 +N G +SET T+ +TGL A Sbjct: 870 ENQFGKIQSET-TVTVTGLVA 889 Score = 56.2 bits (134), Expect = 1e-07 Identities = 136/578 (23%), Positives = 200/578 (34%), Gaps = 62/578 (10%) Query: 290 TLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRCERGASISFSLT 346 ++ E+ +G+ ++ C T ++ + +G PL H +V Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMVLQLLKAE 3497 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLI--FEGAKVTLHCEAQ 404 TE+SG Y C A N G + SK L V P P +N S + I + L C A Sbjct: 3498 TEDSGKYTCIASNEAG-EVSKHFILKVLEP---PHINGSEEHEEISVIVNNPLELTCIAS 3553 Query: 405 RGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA--EHSGNYYCTADNGFGPQRSKAV 462 P + + + GG + TA E +G Y C A + G K Sbjct: 3554 GIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEY 3612 Query: 463 SLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV 522 + V VP + T + VTL C+ P ++ + + +TP V Sbjct: 3613 LVRVHVP-PNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGER---LQATPRV 3668 Query: 523 -----GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQA 577 GR + G + NY C A N G E + L V VP P + Sbjct: 3669 RILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI-LTVNVP---PNIKGGPQSLVI 3724 Query: 578 VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEH---SGNYSC 634 ++ L C A P + W V G+ + S E F L + + H +G Y C Sbjct: 3725 LLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF-LHIQSAHVTDTGRYLC 3783 Query: 635 EANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYW-- 692 A N I L V VP P + +V L CEA P + W Sbjct: 3784 MATNAAGTDRR-RIDLQVHVP---PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRK 3839 Query: 693 ---FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPV 749 + D S G +S + + + Y C NG + V L V VP Sbjct: 3840 NGHLLNVDQNQNSYRLLSSGSLVI-ISPSVDDTATYECTVTNGAGDDK-RTVDLTVQVPP 3897 Query: 750 SRP------VLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSP---- 799 S ++T AP + C A G P + + L R Sbjct: 3898 SIADEPTDFLVTKHAPAV---------ITCTA-SGVPFPSIHWTKNGIRLLPRGDGYRIL 3947 Query: 800 SGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYI 837 S GA L+ H+G Y+C A N G+ VTL++ Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAHRH-VTLHV 3984 Score = 51.6 bits (122), Expect = 4e-06 Identities = 107/473 (22%), Positives = 181/473 (38%), Gaps = 86/473 (18%) Query: 40 VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILE--------VQ--ESGEYRCQAQG 89 +TL+C+ P T W+ G+ I+ +L VQ ++G Y C A Sbjct: 4096 ITLSCEADGLPPPDIT-WHKD--GRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN 4152 Query: 90 SPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEVT--LNNTIYKN 138 SS +S L + P +V E +L C A T +N +K Sbjct: 4153 VAGSSS-----TSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAIN---WKK 4204 Query: 139 DNVLA--FLNKRT-----DFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTR 191 DNVL L K T + + + L+D+G Y C + + ++ + V FT Sbjct: 4205 DNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTE 4264 Query: 192 PVLRASSFQPISGNPVTLTCETQ--------LSLERSDVPLRFRFFRDDQTLGLGWSLSP 243 G + L+C+ + + +P F L Sbjct: 4265 ---LPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSEL-------- 4313 Query: 244 NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLS-PEKALNFEGT 302 I + +DSG Y C A SV ++ V+ P PV P + G Sbjct: 4314 --VIERVSKEDSGTYVCTAEN---SVGFVKAIGFVYVKEP---PVFKGDYPSNWIEPLGG 4365 Query: 303 KVTLHCETQEDSLRTLYRFYHEGVPLR--HKSVRCERGASISFSLTTENSGNYYCTADNG 360 L+CE + D T+ ++ +GV + H+ + G+ + E++G+Y C A N Sbjct: 4366 NAILNCEVKGDPTPTI-QWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424 Query: 361 LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA 420 G +++SL++ P P++ L E +I G K+ L+C+A P + + +G + Sbjct: 4425 AGVV-ERSMSLTLQSP---PIITLEPVETVINAGGKIILNCQATGEPQPTI-TWSRQGHS 4479 Query: 421 L---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPV 470 + +R + S + I+ E + + C A N G S+ V VPV Sbjct: 4480 ISWDDRVNVLSNNSLYIA-DAQKEDTSEFECVARNLMG-------SVLVRVPV 4524 >gi|126116592 Fc fragment of IgG, low affinity IIc, receptor [Homo sapiens] Length = 323 Score = 111 bits (278), Expect = 3e-24 Identities = 73/198 (36%), Positives = 98/198 (49%), Gaps = 8/198 (4%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L LAPV+G A P+ ++ L+P W V Q + VTLTC+G W+H Sbjct: 28 MLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHN 87 Query: 61 YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116 G I T + +SGEY CQ + LS PVHL S L+LQ P L EG Sbjct: 88 --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 145 Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175 +++VLRC + K + + T ++N F +F IP A +G Y CTG Sbjct: 146 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 204 Query: 176 VSSNTVKIQVQEPFTRPV 193 SS V I VQ P + P+ Sbjct: 205 YSSKPVTITVQAPSSSPM 222 Score = 51.2 bits (121), Expect = 5e-06 Identities = 57/245 (23%), Positives = 94/245 (38%), Gaps = 29/245 (11%) Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732 D + L C S + WF++ ++ P+ S+ SG Y+C+ Sbjct: 65 DSVTLTCRGTHSPESDSIPWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 116 Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 + S+ V L V L L+ P G+ + L C + + PL+ FF Sbjct: 117 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 168 Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849 +S + N S+ HSG+Y C + G S+ VT+ + +++ G Sbjct: 169 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 225 Query: 850 TGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQ 909 V G+ A +AA L+YC +K S + P + EP + A + Q Sbjct: 226 VAVVTGIAVAAIVAAVVALIYC------RKKRISANSTDPVKAAQFEPPGRQMIAIRKRQ 279 Query: 910 PVYTN 914 P TN Sbjct: 280 PEETN 284 Score = 49.7 bits (117), Expect = 1e-05 Identities = 60/273 (21%), Positives = 99/273 (36%), Gaps = 30/273 (10%) Query: 283 PASHP--VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGAS 340 PA+ P VL L P+ + VTL C ++H G + S Sbjct: 44 PAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHNG-----NLIPTHTQPS 98 Query: 341 ISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLH 400 F +SG Y C + P LS + + P L EG + L Sbjct: 99 YRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLR 151 Query: 401 CEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSK 460 C + + + F G + ++ + S +I HSG+Y+CT + G+ SK Sbjct: 152 CHSWKDKPLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSK 208 Query: 461 AVSLSVTVPVSHPV-----LTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515 V+++V P S P+ + A A ++C +R S + P+ Sbjct: 209 PVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISA-------NSTDPVK 261 Query: 516 SSSTPSVGRVSFSFSLTE-GHSGNYYCTADNGF 547 ++ GR + + + N Y TAD G+ Sbjct: 262 AAQFEPPGRQMIAIRKRQPEETNNDYETADGGY 294 Score = 43.9 bits (102), Expect = 7e-04 Identities = 39/172 (22%), Positives = 70/172 (40%), Gaps = 18/172 (10%) Query: 599 WFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSR 658 WF++ ++ P+ + S+ SG Y+C+ + SD + L+V+ Sbjct: 84 WFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL----S 130 Query: 659 PILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLT 718 L + P + G+ + L C + + + F+ GK S +F++ Sbjct: 131 EWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIPQA 186 Query: 719 TE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLL 769 HSG Y C + G S+ VT+ V P S P+ + A T AV ++ Sbjct: 187 NHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIV 238 Score = 43.1 bits (100), Expect = 0.001 Identities = 43/190 (22%), Positives = 69/190 (36%), Gaps = 21/190 (11%) Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440 VL L + + VTL C + H G + + S F Sbjct: 51 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHNGNLIPTHTQPS-----YRFKANN 105 Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500 SG Y C ++S V + V L L + EG T+ L C + Sbjct: 106 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 158 Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557 P + F+ + + R +FS+ + HSG+Y+CT + G+ S+ V++ Sbjct: 159 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 212 Query: 558 FVTVPVSRPI 567 V P S P+ Sbjct: 213 TVQAPSSSPM 222 >gi|132814489 low affinity immunoglobulin gamma Fc region receptor III-B precursor [Homo sapiens] Length = 233 Score = 110 bits (275), Expect = 6e-24 Identities = 76/209 (36%), Positives = 108/209 (51%), Gaps = 16/209 (7%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58 +LL LL+L + P+ ++FL+P W +V + + VTL C+G YSP+ T+W+ Sbjct: 4 LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQG--AYSPEDNSTQWF 61 Query: 59 HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114 H + ++ + V +SGEYRCQ S LS PV L+ L+LQAP VF Sbjct: 62 H---NENLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 118 Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172 E D + LRC + L+ Y +N + + +DFHIP A LKD+G+Y C G S Sbjct: 119 KEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGS 178 Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQP 201 VSS TV I + + V SSF P Sbjct: 179 -KNVSSETVNITITQGLA--VSTISSFSP 204 Score = 37.7 bits (86), Expect = 0.053 Identities = 43/182 (23%), Positives = 85/182 (46%), Gaps = 18/182 (9%) Query: 112 SVFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYK 170 SV E DSV L+C+ N+T + N+N+++ ++ + + I A + D+G YRC Sbjct: 36 SVLEKDSVTLKCQGAYSPEDNSTQWFHNENLIS--SQASSYFIDAATVNDSGEYRC---- 89 Query: 171 ESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFR 230 ++ S+ V+++V + +L+A + +P+ L C + + V + + Sbjct: 90 QTNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVTY-LQNGK 146 Query: 231 DDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLT 290 D + + + +F I KDSG Y+C+ +V S++ + + I V T Sbjct: 147 DRKY----FHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSET----VNITITQGLAVST 198 Query: 291 LS 292 +S Sbjct: 199 IS 200 >gi|110347451 platelet/endothelial cell adhesion molecule [Homo sapiens] Length = 738 Score = 109 bits (273), Expect = 1e-23 Identities = 161/703 (22%), Positives = 278/703 (39%), Gaps = 82/703 (11%) Query: 299 FEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTAD 358 F T H + Q L FY + V + S + + +SG Y CT Sbjct: 58 FADVSTTSHVKPQHQML-----FYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVI 112 Query: 359 NGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFH--- 415 K + L V V P + L E + +G V ++C PI + Sbjct: 113 VNNKEKTTAEYQLLVE-GVPSPRVTLDKKEAI--QGGIVRVNCSVPEEKAPIHFTIEKLE 169 Query: 416 -HEGAALERRSANSAGGVAISFSLTAEHSG---NYYCTAD--NGFGPQRSKAVS---LSV 466 +E +R NS + E ++ C A +G Q S++ ++V Sbjct: 170 LNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTV 229 Query: 467 TVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-----RGSPQILYQFYHEDMPLWSSSTPS 521 T S P +S + EGA + + C +Q + P+I+ Q +D + + + Sbjct: 230 TESFSTPKFHISPT-GMIMEGAQLHIKCTIQVTHLAQEFPEIIIQ---KDKAIVAHNRHG 285 Query: 522 VGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGD 581 V ++ E HSGNY C ++ + S +V + +T S+P L G+ Sbjct: 286 NKAVYSVMAMVE-HSGNYTCKVESSRISKVSSIV-VNITELFSKPELESSFTHLDQ--GE 341 Query: 582 LLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLV 641 L L C P G+PP + ED + + F + SG Y C A V Sbjct: 342 RLNLSCSIP-GAPPANFTIQKEDTIVSQTQ-------DFTKIASKSDSGTYICTAGIDKV 393 Query: 642 AQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701 + S+T+ + V +S+P +++ A + + + G +E+ CE++ G+ PI Y L Sbjct: 394 VKKSNTVQIVVCEMLSQPRISYDA-QFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLE 452 Query: 702 KISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQR--SEMVTLKVAVPVSRPVLTLRAP 759 + S A F + T + Y C ADN + SE++ +KV PV +++ + Sbjct: 453 NSTKNSNDPAVFKDNPTEDVE--YQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSS 510 Query: 760 GTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGAS---LNLSLTAEHSGN 816 + D++ L C GS I Y+F+ E S + E G Sbjct: 511 KVVESGEDIV-LQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKASKEQEGE 569 Query: 817 YSC----EADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCW 872 Y C A++ RS+ +T+ + L + G A + G ++++ +AA C+ Sbjct: 570 YYCTAFNRANHASSVPRSKILTVRVI-LAPWKKGLIAVVIIGVIIALLIIAA-----KCY 623 Query: 873 LSRKAGRK----PASDPARSPSDSDSQEPTYHNVPAWEE-----------LQPVYTNANP 917 RKA K S PA +S++++ + N+ A ++P+ N P Sbjct: 624 FLRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEANSHYGHNDDVRNHAMKPINDNKEP 683 Query: 918 RGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA 960 +V Y+EV++ + A + L K + +YSEV+ A Sbjct: 684 LNSDVQYTEVQV-------SSAESHKDLGKKDTETVYSEVRKA 719 Score = 96.3 bits (238), Expect = 1e-19 Identities = 132/575 (22%), Positives = 234/575 (40%), Gaps = 61/575 (10%) Query: 203 SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSL---SPNFQITAMWSKDSGFYW 259 +G +TL C +S P F D L S + ++ I + DSG Y Sbjct: 49 NGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYK 108 Query: 260 CKAATMPYSVISDSPRSWIQVQIPAS---HPVLTLSPEKALNFEGTKVTLHCETQEDSLR 316 C ++++ ++ + Q+ P +TL ++A+ +G V ++C E+ + Sbjct: 109 CTV------IVNNKEKTTAEYQLLVEGVPSPRVTLDKKEAI--QGGIVRVNCSVPEE--K 158 Query: 317 TLYRFYHEGVPLRHKSVRCERGAS--------ISFSLTTENSG-NYYCTADNGLG----- 362 F E + L K V+ +R + + F + ++ ++ C A G Sbjct: 159 APIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQT 218 Query: 363 AKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL----PILYQFHHEG 418 ++ +K+ ++VT S P ++S P +I EGA++ + C Q L P + + Sbjct: 219 SESTKSELVTVTESFSTPKFHIS-PTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKA 277 Query: 419 AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLS 478 R N A S EHSGNY C ++ + SK S+ V + L Sbjct: 278 IVAHNRHGNKA---VYSVMAMVEHSGNYTCKVESS---RISKVSSIVVNITELFSKPELE 331 Query: 479 SAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGN 538 S+ +G + L C + G+P + ED + S T +++ ++ SG Sbjct: 332 SSFTHLDQGERLNLSCSIP-GAPPANFTIQKEDTIV--SQTQDFTKIA-----SKSDSGT 383 Query: 539 YYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY 598 Y CTA ++S V + V +S+P ++ + + + G +E+ CE+ G+ PI Y Sbjct: 384 YICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDA-QFEVIKGQTIEVRCESISGTLPISY 442 Query: 599 WFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANN--GLVAQHSDTISLSVIVPV 656 L +S+ S A F + T + Y C A+N S+ + + VI PV Sbjct: 443 QLLKTSKVLENSTKNSNDPAVFKDNPTEDVE--YQCVADNCHSHAKMLSEVLRVKVIAPV 500 Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASF--N 714 ++ + + G+ + L C GS PI Y FY E S +F Sbjct: 501 DEVQISILSSKV-VESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTK 559 Query: 715 LSLTTEHSGIYSC----EADNGLEAQRSEMVTLKV 745 + E G Y C A++ RS+++T++V Sbjct: 560 QKASKEQEGEYYCTAFNRANHASSVPRSKILTVRV 594 Score = 89.4 bits (220), Expect = 2e-17 Identities = 138/580 (23%), Positives = 230/580 (39%), Gaps = 68/580 (11%) Query: 112 SVFEGDSVVLRCRAKAEVTLN-----NTIYKNDNVLAF----LNKRTDFHIPHACLKDNG 162 +V G ++ L+C A T + ++ D+VL + + + IP + D+G Sbjct: 46 TVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSG 105 Query: 163 AYRCT-----------GYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTC 211 Y+CT Y+ V S V + +E ++R + P P+ T Sbjct: 106 TYKCTVIVNNKEKTTAEYQLLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTI 165 Query: 212 ETQLSLERSDVPL-RFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP--YS 268 E +L L V L R + RD + L + + ++ + + C+A + + Sbjct: 166 E-KLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLS--------FRCQARIISGIHM 216 Query: 269 VISDSPRS-WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVP 327 S+S +S + V S P +SP + EG ++ + C Q + L + + E + Sbjct: 217 QTSESTKSELVTVTESFSTPKFHISP-TGMIMEGAQLHIKCTIQ---VTHLAQEFPEIII 272 Query: 328 LRHKSV----RCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLN 383 + K++ R A S E+SGNY C ++ +K S V +++T S P L Sbjct: 273 QKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIV-VNITELFSKPELE 331 Query: 384 LSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHS 443 S + +G ++ L C G+ P + E + + + + S Sbjct: 332 SSFTH--LDQGERLNLSCSIP-GAPPANFTIQKEDTIVSQTQ-------DFTKIASKSDS 381 Query: 444 GNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQI 503 G Y CTA ++S V + V +S P ++ A+ +G T+ + CE G+ I Sbjct: 382 GTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISY-DAQFEVIKGQTIEVRCESISGTLPI 440 Query: 504 LYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADN--GFGPQRSEVVSLFVTV 561 YQ L +S+ S F + TE Y C ADN SEV+ + V Sbjct: 441 SYQLLKTSKVLENSTKNSNDPAVFKDNPTE--DVEYQCVADNCHSHAKMLSEVLRVKVIA 498 Query: 562 PVSR---PILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEA 618 PV IL+ +V + G+ + L C GS PI Y FY E S Sbjct: 499 PVDEVQISILSSKVVES----GEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQ 554 Query: 619 SF--NLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656 +F + E G Y C A N A H+ ++ S I+ V Sbjct: 555 AFWTKQKASKEQEGEYYCTAFNR--ANHASSVPRSKILTV 592 Score = 38.1 bits (87), Expect = 0.041 Identities = 59/265 (22%), Positives = 106/265 (40%), Gaps = 49/265 (18%) Query: 27 LQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKE--ILRETPD--NILEVQESGE 82 L+ +T + QGER+ L+C S + + KE I+ +T D I +SG Sbjct: 330 LESSFTHLDQGERLNLSC------SIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGT 383 Query: 83 YRCQA-------QGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA-KAEVTLNNT 134 Y C A + + + V S + A V +G ++ +RC + + ++ Sbjct: 384 YICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQ 443 Query: 135 IYKNDNVLAFLNKRTDFHIPHACLKDNGA----YRCTGYK-ESCCPVSSNTVKIQVQEPF 189 + K VL K ++ A KDN Y+C S + S ++++V P Sbjct: 444 LLKTSKVLENSTKNSN---DPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPV 500 Query: 190 TRPVLRASSFQPI-SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQIT 248 + S + + SG + L C ++ P+ ++F+R+ + P +Q+T Sbjct: 501 DEVQISILSSKVVESGEDIVLQC----AVNEGSGPITYKFYREKEG-------KPFYQMT 549 Query: 249 -----AMWSK------DSGFYWCKA 262 A W+K G Y+C A Sbjct: 550 SNATQAFWTKQKASKEQEGEYYCTA 574 >gi|50511928 Fc fragment of IgG, low affinity IIb, receptor isoform 4 [Homo sapiens] Length = 309 Score = 108 bits (269), Expect = 3e-23 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 9/198 (4%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L LAPV+G A P+ ++ L+P W V Q + VTLTC+G +W+H Sbjct: 28 MLLWTAVLFLAPVAGTPA-PPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 86 Query: 61 YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116 G I T + +SGEY CQ + LS PVHL S L+LQ P L EG Sbjct: 87 --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 144 Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175 +++VLRC + K + + T ++N F +F IP A +G Y CTG Sbjct: 145 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 203 Query: 176 VSSNTVKIQVQEPFTRPV 193 SS V I VQ P + P+ Sbjct: 204 YSSKPVTITVQAPSSSPM 221 Score = 48.1 bits (113), Expect = 4e-05 Identities = 43/187 (22%), Positives = 70/187 (37%), Gaps = 15/187 (8%) Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTT 347 VL L P+ + VTL C +++H G + S F Sbjct: 50 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPSYRFKANN 104 Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 +SG Y C + P LS + + P L EG + L C + + Sbjct: 105 NDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLRCHSWKDK 157 Query: 408 LPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVT 467 + F G + ++ + S +I HSG+Y+CT + G+ SK V+++V Sbjct: 158 PLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSKPVTITVQ 214 Query: 468 VPVSHPV 474 P S P+ Sbjct: 215 APSSSPM 221 Score = 48.1 bits (113), Expect = 4e-05 Identities = 47/202 (23%), Positives = 79/202 (39%), Gaps = 23/202 (11%) Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732 D + L C S + WF++ ++ P+ S+ SG Y+C+ Sbjct: 64 DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 115 Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 + S+ V L V L L+ P G+ + L C + + PL+ FF Sbjct: 116 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 167 Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849 +S + N S+ HSG+Y C + G S+ VT+ + +++ G Sbjct: 168 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 224 Query: 850 TGVAGGLLSIAGLAAGALLLYC 871 V G+ A +AA L+YC Sbjct: 225 VAVVTGIAVAAIVAAVVALIYC 246 Score = 45.4 bits (106), Expect = 3e-04 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%) Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440 VL L + + VTL C Q+ H G + + S F Sbjct: 50 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 104 Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500 SG Y C ++S V + V L L + EG T+ L C + Sbjct: 105 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 157 Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557 P + F+ + + R +FS+ + HSG+Y+CT + G+ S+ V++ Sbjct: 158 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 211 Query: 558 FVTVPVSRPI 567 V P S P+ Sbjct: 212 TVQAPSSSPM 221 Score = 44.7 bits (104), Expect = 4e-04 Identities = 43/191 (22%), Positives = 77/191 (40%), Gaps = 23/191 (12%) Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656 + WF++ ++ P+ + S+ SG Y+C+ + SD + L+V+ Sbjct: 81 IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 128 Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716 L + P + G+ + L C + + + F+ GK S +F++ Sbjct: 129 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 183 Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLE----- 770 HSG Y C + G S+ VT+ V P S P+ + A T AV ++ Sbjct: 184 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVAL 243 Query: 771 LHCEALRGSPL 781 ++C R S L Sbjct: 244 IYCRKKRISAL 254 >gi|50511932 Fc fragment of IgG, low affinity IIb, receptor isoform 2 [Homo sapiens] Length = 290 Score = 108 bits (269), Expect = 3e-23 Identities = 73/198 (36%), Positives = 99/198 (50%), Gaps = 9/198 (4%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR 60 MLLW +L LAPV+G A P+ ++ L+P W V Q + VTLTC+G +W+H Sbjct: 28 MLLWTAVLFLAPVAGTPA-PPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHN 86 Query: 61 YLGKEILRETPDNI---LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAP-LSVFEG 116 G I T + +SGEY CQ + LS PVHL S L+LQ P L EG Sbjct: 87 --GNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG 144 Query: 117 DSVVLRCRA-KAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCP 175 +++VLRC + K + + T ++N F +F IP A +G Y CTG Sbjct: 145 ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTG-NIGYTL 203 Query: 176 VSSNTVKIQVQEPFTRPV 193 SS V I VQ P + P+ Sbjct: 204 YSSKPVTITVQAPSSSPM 221 Score = 48.9 bits (115), Expect = 2e-05 Identities = 50/217 (23%), Positives = 83/217 (38%), Gaps = 23/217 (10%) Query: 674 DLLELHCEALRG-SSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNG 732 D + L C S + WF++ ++ P+ S+ SG Y+C+ Sbjct: 64 DSVTLTCRGTHSPESDSIQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTG-- 115 Query: 733 LEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 + S+ V L V L L+ P G+ + L C + + PL+ FF Sbjct: 116 -QTSLSDPVHLTVL----SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN--- 167 Query: 793 LGNRSSPSGGASLNLSLTA---EHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFA 849 +S + N S+ HSG+Y C + G S+ VT+ + +++ G Sbjct: 168 --GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMG-II 224 Query: 850 TGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPA 886 V G+ A +AA L+YC R + D A Sbjct: 225 VAVVTGIAVAAIVAAVVALIYCRKKRISANPTNPDEA 261 Score = 48.1 bits (113), Expect = 4e-05 Identities = 43/187 (22%), Positives = 70/187 (37%), Gaps = 15/187 (8%) Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTT 347 VL L P+ + VTL C +++H G + S F Sbjct: 50 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNG-----NLIPTHTQPSYRFKANN 104 Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 +SG Y C + P LS + + P L EG + L C + + Sbjct: 105 NDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQ-------EGETIVLRCHSWKDK 157 Query: 408 LPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVT 467 + F G + ++ + S +I HSG+Y+CT + G+ SK V+++V Sbjct: 158 PLVKVTFFQNGKS--KKFSRSDPNFSIP-QANHSHSGDYHCTGNIGYTLYSSKPVTITVQ 214 Query: 468 VPVSHPV 474 P S P+ Sbjct: 215 APSSSPM 221 Score = 45.4 bits (106), Expect = 3e-04 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 21/190 (11%) Query: 381 VLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTA 440 VL L + + VTL C Q+ H G + + S F Sbjct: 50 VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPS-----YRFKANN 104 Query: 441 EHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGS 500 SG Y C ++S V + V L L + EG T+ L C + Sbjct: 105 NDSGEYTCQTGQ-------TSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDK 157 Query: 501 PQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEG---HSGNYYCTADNGFGPQRSEVVSL 557 P + F+ + + R +FS+ + HSG+Y+CT + G+ S+ V++ Sbjct: 158 PLVKVTFFQ------NGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTI 211 Query: 558 FVTVPVSRPI 567 V P S P+ Sbjct: 212 TVQAPSSSPM 221 Score = 44.3 bits (103), Expect = 6e-04 Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 18/174 (10%) Query: 597 LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPV 656 + WF++ ++ P+ + S+ SG Y+C+ + SD + L+V+ Sbjct: 81 IQWFHNGNLI------PTHTQPSYRFKANNNDSGEYTCQTGQTSL---SDPVHLTVL--- 128 Query: 657 SRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLS 716 L + P + G+ + L C + + + F+ GK S +F++ Sbjct: 129 -SEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQN----GKSKKFSRSDPNFSIP 183 Query: 717 LTTE-HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLL 769 HSG Y C + G S+ VT+ V P S P+ + A T AV ++ Sbjct: 184 QANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIV 237 >gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] Length = 4391 Score = 107 bits (268), Expect = 4e-23 Identities = 178/816 (21%), Positives = 311/816 (38%), Gaps = 78/816 (9%) Query: 108 QAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFH----IPHACLKDNGA 163 Q SV G V C AK++ ++ + + DF+ I + L D G Sbjct: 1778 QRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGT 1837 Query: 164 YRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVP 223 Y CTG + T+ +Q + PV+ Q ++ P L E + S S P Sbjct: 1838 YVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQ-LTVQPGQLA-EFRCSATGSPTP 1895 Query: 224 LRFRFFRDDQTLGLGWSLSPNFQI-------TAMWSKDSGFYWCKAATMPYSVISDSPRS 276 + T G G L QI A+ D Y C+A + ++ R+ Sbjct: 1896 TL------EWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVA---RA 1946 Query: 277 WIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTL-YRFYHEGVPLRHKSVRC 335 + V P + +SPE+ G V L+C T+ +R +P + +S R Sbjct: 1947 VLHVH-GGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT 2005 Query: 336 ERGASISFSLTTENSGNYYCTADNGLGAKPSK--AVSLSVTVPVSHPVLNLSSPEDLIFE 393 + + ++TT ++G Y C A + G ++ V LS + S P + + S + E Sbjct: 2006 DIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSAS-DASPPPVKIESSSPSVTE 2064 Query: 394 GAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNG 453 G + L+C GS ++ G +L + + + ++ SG Y C +NG Sbjct: 2065 GQTLDLNCVVA-GSAHAQVTWYRRGGSLPPHTQVHGSRLRLP-QVSPADSGEYVCRVENG 2122 Query: 454 FGPQRSKAVSLSVT-----------VPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSP 501 GP+ + ++++SV VP S + + + + EG T+ L+C V + Sbjct: 2123 SGPKEA-SITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHA 2181 Query: 502 QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTV 561 Q+ + +P + S+ R+ +T SG Y C GP + V+ Sbjct: 2182 QVTWHKRGGSLPARHQTHGSLLRLH---QVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238 Query: 562 PVSRPILTLRVPRAQAVV--GDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSG---- 615 + PI +R+ + + V G L+L C + + W+ S P+ Sbjct: 2239 VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR------GGSLPARHQVR 2292 Query: 616 GEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI-----LTFRAPRAQA 670 G + + +G Y C A+NG+ A + T++ + ++ P + +Q Sbjct: 2293 GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV 2352 Query: 671 VVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEA- 729 G L+L+C S + W H+ + + G + SG Y C Sbjct: 2353 AEGQTLDLNCVVPGQSHAQVTW--HKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL 2410 Query: 730 DNGLEAQRSEMVTLKVAVPVSR----PVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785 + + + S +VT++ A V P + + + + A G L+L+C + G Sbjct: 2411 GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC-LVAGQAHAQVT 2469 Query: 786 FFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRS 845 + +L R G L +T SG Y C G Q + + + S Sbjct: 2470 WHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASV----LVTIQQRLS 2525 Query: 846 GPFATGVAGGL---LSIAGLAAGALL-LYCWLSRKA 877 G + GVA + S A LA G L L C ++ +A Sbjct: 2526 GSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA 2561 Score = 101 bits (252), Expect = 3e-21 Identities = 206/922 (22%), Positives = 339/922 (36%), Gaps = 133/922 (14%) Query: 9 VLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILR 68 VL + P P + ++ +TV +G+ + L+C Q T WY R Sbjct: 2231 VLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT-WYKRGGSLPARH 2289 Query: 69 ETPDNILEV-----QESGEYRCQA---------------QGSPLSSPVHLDFSSASLILQ 108 + + L + ++G+Y C+A QG+ L+ P S I Sbjct: 2290 QVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPA----GSTQPIRI 2345 Query: 109 APLS--VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTD--FHIPHACLKDNGAY 164 P S V EG ++ L C + T +K L ++ + A D+G Y Sbjct: 2346 EPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEY 2405 Query: 165 RCTGYKESCCPVSSNTVKIQ----VQEPFTRPVLR--ASSFQPISGNPVTLTC------E 212 C S +S V I+ V P +R +SS Q G + L C Sbjct: 2406 VCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAH 2465 Query: 213 TQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK----AATMPYS 268 Q++ + L R L L Q+T DSG Y C+ + T S Sbjct: 2466 AQVTWHKRGGSLPARHQVHGSRLRL-------LQVTPA---DSGEYVCRVVGSSGTQEAS 2515 Query: 269 VISDSPRSWIQVQIPASH------PVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFY 322 V+ IQ ++ SH PV S +L G + L+C + T+ + Sbjct: 2516 VLVT-----IQQRLSGSHSQGVAYPVRIESSSASLA-NGHTLDLNCLVASQAPHTITWYK 2569 Query: 323 HEG-VPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLGAKPSKAV-----SLSVTV 375 G +P RH+ V G+ + +T +SG Y C NG G++ + + S S V Sbjct: 2570 RGGSLPSRHQIV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHV 2625 Query: 376 PVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAIS 435 P P + + S + EG + L+C R I+ + G+ R + G Sbjct: 2626 PSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH--GSHLRL 2683 Query: 436 FSLTAEHSGNYYCTADNGFGPQRSKAV------SLSVTVPVSHPVLTLSSAEALTFEGAT 489 ++ SG Y C A+N + V + S + P S + + S+ + EG T Sbjct: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743 Query: 490 VTLHCEVQ-RGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFG 548 + L+C V + Q+ + +P + S R+ ++ SG Y C G Sbjct: 2744 LDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHH---VSPADSGEYVCRVMGSSG 2800 Query: 549 PQRSEVV---------SLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYW 599 P + V+ ++ V P P + + ++ G L+L C P + + W Sbjct: 2801 PLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTW 2860 Query: 600 FYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIV----- 654 + L + G N A+ SG YSC+ V S T+ SV+V Sbjct: 2861 -HKRGGNLPARHQVHGPLLRLNQVSPAD-SGEYSCQ-----VTGSSGTLEASVLVTIEPS 2913 Query: 655 ---PVSRPILT----FRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPS 707 P+ P L A + G L+L+C + G + +Y +L Sbjct: 2914 SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNC-VVPGQAHAQVTWYKRGGSLPARHQTH 2972 Query: 708 GGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSR--------PVLTLRAP 759 G +L ++ SG Y C A +G ++ T V VP S PV+++ P Sbjct: 2973 GSQLRLHL-VSPADSGEYVCRAASGPGPEQEASFT--VTVPPSEGSSYRLRSPVISIDPP 3029 Query: 760 GTHAAVGDLLELHCEALRGS-PLIL-YRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNY 817 + G C G+ P+ L ++ ++++ SP+G + + G Y Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTY 3089 Query: 818 SCEADNGLGAQRSETVTLYITG 839 C A N G +S V L + G Sbjct: 3090 RCVASNAYGVAQS-VVNLSVHG 3110 Score = 96.3 bits (238), Expect = 1e-19 Identities = 184/799 (23%), Positives = 296/799 (37%), Gaps = 110/799 (13%) Query: 112 SVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFH-----IPHACLKDNGAYRC 166 SV EG ++ L C T Y+ L T H +P D+G Y C Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP---PHTQVHGSRLRLPQVSPADSGEYVC 2117 Query: 167 -----TGYKESCCPVS----SNTVKIQVQEP-FTRPV-LRASSFQPISGNPVTLTC---- 211 +G KE+ VS +++ P TRP+ + SS G + L C Sbjct: 2118 RVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPG 2177 Query: 212 --ETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK----AATM 265 Q++ + L R QT G SL Q+T DSG Y C + + Sbjct: 2178 QAHAQVTWHKRGGSLPARH----QTHG---SLLRLHQVTPA---DSGEYVCHVVGTSGPL 2227 Query: 266 PYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG 325 SV+ S IP P + + + EG + L C + + + G Sbjct: 2228 EASVLVTIEAS----VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG 2283 Query: 326 -VPLRHKSVRCERGASIS-FSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPV-- 381 +P RH+ RG+ + F + ++G Y C A NG+ A + V+ + +++P Sbjct: 2284 SLPARHQV----RGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGS 2339 Query: 382 ---LNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSL 438 + + + EG + L+C G +H G +L R + G + + Sbjct: 2340 TQPIRIEPSSSQVAEGQTLDLNCVVP-GQSHAQVTWHKRGGSLPVRH-QTHGSLLRLYQA 2397 Query: 439 TAEHSGNYYCTADNGFGP-QRSKAVSL----SVTVPVSHPVLTLSSAEALTFEGATVTLH 493 + SG Y C P + S V++ SV P + + S+ + EG T+ L+ Sbjct: 2398 SPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLN 2457 Query: 494 CEVQ-RGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRS 552 C V + Q+ + +P S R+ +T SG Y C G Q + Sbjct: 2458 CLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRL---LQVTPADSGEYVCRVVGSSGTQEA 2514 Query: 553 EVVSLFVTVP----------VSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYH 602 V+ VT+ V+ P+ + A G L+L+C +P + W Y Sbjct: 2515 SVL---VTIQQRLSGSHSQGVAYPV-RIESSSASLANGHTLDLNCLVASQAPHTITW-YK 2569 Query: 603 EDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTI-----SLSVIVPVS 657 +L S G +T SG Y C +NG ++ + I S S VP Sbjct: 2570 RGGSLPSRHQIVGSRLRIP-QVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628 Query: 658 RPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSL 717 P + + V G L+L+C R I+ W Y +L G + + Sbjct: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITW-YKRGGSLPSRHQTHGSHLRLH-QM 2686 Query: 718 TTEHSGIYSCEADNGLEAQRSEMVTL------KVAVPVSRPVLTLRAPGTHAAVGDLLEL 771 + SG Y C A+N ++A + +V + P S + + + +H A G+ L+L Sbjct: 2687 SVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746 Query: 772 HCEALRGSPLILYRFFHEDVTLGNR--SSPSGGASLNLSLTAEH-----SGNYSCEADNG 824 +C ++ H VT R S PS + L H SG Y C Sbjct: 2747 NC--------VVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGS 2798 Query: 825 LG-AQRSETVTLYITGLTA 842 G + S VT+ +G +A Sbjct: 2799 SGPLEASVLVTIEASGSSA 2817 Score = 94.4 bits (233), Expect = 5e-19 Identities = 192/822 (23%), Positives = 288/822 (35%), Gaps = 102/822 (12%) Query: 79 ESGEYRCQAQGS--PLSSPVHLDFS---SASLILQAP------------LSVFEGDSVVL 121 +SGEY C+ GS PL + V + S+++ + AP V EG ++ L Sbjct: 2787 DSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDL 2846 Query: 122 RCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLK-----DNGAYRCTGYKESCCPV 176 +C + T +K L R H P L D+G Y C S Sbjct: 2847 KCVVPGQAHAQVTWHKRGGNLP---ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLE 2903 Query: 177 SSNTVKIQVQEPFTRPV--------LRASSFQPISGNPVTLTC------ETQLSLERSDV 222 +S V I+ P P + ASS G + L C Q++ + Sbjct: 2904 ASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGG 2963 Query: 223 PLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQI 282 L R QT G ++ + DSG Y C+AA+ P + V + Sbjct: 2964 SLPARH----QTHG------SQLRLHLVSPADSGEYVCRAASGP----GPEQEASFTVTV 3009 Query: 283 PASH--------PVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVR 334 P S PV+++ P + +G + C + + + L Sbjct: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 3069 Query: 335 CERGASISFSLTT-ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE 393 G+ I+ T N G Y C A N G S V+LSV P + VL PE ++ Sbjct: 3070 SPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS-VVNLSVHGPPTVSVL----PEGPVWV 3124 Query: 394 --GAKVTLHCEA--QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHS--GNYY 447 G VTL C + + S + A LE+R+ A+ +A+ S G Y Sbjct: 3125 KVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYV 3184 Query: 448 CTADNGFGPQRSKAVSLSVTVPVSH--PVLTLSSAEALTFEGATVTLHCEVQRGSPQILY 505 C A N G + + + T ++ P + AE G T TL C GSP Sbjct: 3185 CLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT-GSPAPTI 3243 Query: 506 QFYHEDMPL-WSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVS 564 + PL W G + + SG Y C A + G + ++ L V P Sbjct: 3244 HWSKLRSPLPWQHRLE--GDTLIIPRVAQQDSGQYICNATSPAGHAEATII-LHVESP-- 3298 Query: 565 RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSL 624 P T A G+ ++L C A G+PP+ + + +L + F + Sbjct: 3299 -PYATTVPEHASVQAGETVQLQCLA-HGTPPLTFQWSRVGSSLPGRATARNELLHFERA- 3355 Query: 625 TAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAV----------VGD 674 E SG Y C N + + + L P S P + A V +G Sbjct: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGA 3415 Query: 675 LLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL- 733 +E HC L WF S G NL + + G Y C+A Sbjct: 3416 SVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQ--GTYICQAHGPWG 3473 Query: 734 EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL 793 +AQ S + ++ V ++ +R VG +E C AL G P + L Sbjct: 3474 KAQASAQLVIQALPSV---LINIRTSVQTVVVGHAVEFECLAL-GDPKPQVTWSKVGGHL 3529 Query: 794 GNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTL 835 SGG + +G Y C A N G +S + L Sbjct: 3530 RPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLL 3571 Score = 93.2 bits (230), Expect = 1e-18 Identities = 184/885 (20%), Positives = 321/885 (36%), Gaps = 114/885 (12%) Query: 23 PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDN-------IL 75 P++ + PP TV G+ C SP T + G ++ + + + Sbjct: 1866 PVVSIHPPQLTVQPGQLAEFRCSATG--SPTPTLEWTGGPGGQLPAKAQIHGGILRLPAV 1923 Query: 76 EVQESGEYRCQAQGSP----LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEV 129 E + +Y C+A S + +H+ + +P V G +V L CRA Sbjct: 1924 EPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVP 1983 Query: 130 TLNNTIYKNDNVL--AFLNKRTDFH---IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQ 184 + T K L ++RTD IP D G Y C + P + +IQ Sbjct: 1984 SATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCV----ATSPAGTAQARIQ 2039 Query: 185 V-----QEPFTRPV-LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLG 238 V + PV + +SS G + L C S R G Sbjct: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR-----------RG 2088 Query: 239 WSLSPNFQI-------TAMWSKDSGFYWC--------KAATMPYSVISDSPRSWIQVQIP 283 SL P+ Q+ + DSG Y C K A++ SV+ + +P Sbjct: 2089 GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVP 2148 Query: 284 ASHPVLTLSPEKALNFEGTKVTLHCETQ-EDSLRTLYRFYHEGVPLRHKSVRCERGASIS 342 S + + P + EG + L+C + + + +P RH++ G+ + Sbjct: 2149 GSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQT----HGSLLR 2204 Query: 343 F-SLTTENSGNYYCTADNGLG-AKPSKAVSLSVTV-PVSHPVLNLSSPEDLIFEGAKVTL 399 +T +SG Y C G + S V++ +V P P + + S + EG + L Sbjct: 2205 LHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264 Query: 400 HCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459 C G ++ G +L R G F + +G Y C A NG + Sbjct: 2265 SC-VVAGQAHAQVTWYKRGGSLPARH-QVRGSRLYIFQASPADAGQYVCRASNGMEASIT 2322 Query: 460 KAVSLSVTVPVSHPV-----LTLSSAEALTFEGATVTLHCEVQ-RGSPQILYQFYHEDMP 513 V+ + +++P + + + + EG T+ L+C V + Q+ + +P Sbjct: 2323 VTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP 2382 Query: 514 LWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFV---TVPVSRPILTL 570 + + S+ R+ + + SG Y C P + V+ +VP T+ Sbjct: 2383 VRHQTHGSLLRL---YQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTV 2439 Query: 571 RV--PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEH 628 R+ +Q G L+L+C + + W + +L + G L +T Sbjct: 2440 RIESSSSQVAEGQTLDLNCLVAGQAHAQVTW-HKRGGSLPARHQVHGSRLRL-LQVTPAD 2497 Query: 629 SGNYSCEANNGLVAQHSDTISLSVIVPVSRPI-----------LTFRAPRAQAVVGDLLE 677 SG Y C V S T SV+V + + + + + A G L+ Sbjct: 2498 SGEYVCR-----VVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552 Query: 678 LHCEALRGSSPILYWFYHEDVTLGKISAPSGG---GASFNL-SLTTEHSGIYSCEADNGL 733 L+C + + W+ S PS G+ + +T SG Y C NG Sbjct: 2553 LNCLVASQAPHTITWYKRGG------SLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606 Query: 734 EAQRSEM-VTLKVA----VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFH 788 ++ + + VT++ + VP P + + + G L+L+C R P + ++ Sbjct: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAR-QPQAIITWYK 2665 Query: 789 EDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETV 833 +L +R G ++ SG Y C A+N + A + V Sbjct: 2666 RGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIV 2710 Score = 87.4 bits (215), Expect = 6e-17 Identities = 150/669 (22%), Positives = 251/669 (37%), Gaps = 79/669 (11%) Query: 149 TDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVL------RASSFQPI 202 ++ H P D G Y CT + +++ ++ V E ++P+ R+ S +P Sbjct: 1729 SELHFPSVQPSDAGVYICTC--RNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRP- 1785 Query: 203 SGNPVTLTCETQLS----------LERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS 252 G VT C + L +P R F T+ N Q++ Sbjct: 1786 -GADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIR-------NVQLS---- 1833 Query: 253 KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312 D+G Y C + M +++ + +Q S PV+++ P + G C Sbjct: 1834 -DAGTYVCTGSNM-FAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATG 1891 Query: 313 DSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLS 372 TL G L K+ + G ++ + Y C A + G + ++AV L Sbjct: 1892 SPTPTLEWTGGPGGQLPAKA-QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAV-LH 1949 Query: 373 VTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGV 432 V P + +S + G V L+C A G + EG +L ++ + + Sbjct: 1950 VHGG-GGPRVQVSPERTQVHAGRTVRLYCRAA-GVPSATITWRKEGGSLPPQARSERTDI 2007 Query: 433 AISF--SLTAEHSGNYYCTADN--GFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGA 488 A ++T +G Y C A + G R + V LS + PV SS+ ++T EG Sbjct: 2008 ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT-EGQ 2066 Query: 489 TVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFG 548 T+ L+C V GS +Y L + R+ ++ SG Y C +NG G Sbjct: 2067 TLDLNCVVA-GSAHAQVTWYRRGGSLPPHTQVHGSRLRLP-QVSPADSGEYVCRVENGSG 2124 Query: 549 PQRSEV-VSL---------FVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILY 598 P+ + + VS+ + VP S + + + G L+L+C P + + Sbjct: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184 Query: 599 WFYHEDVTLGSSSAPSGGEASFNL----SLTAEHSGNYSCE---ANNGLVAQHSDTISLS 651 W S P+ + +L +T SG Y C + L A TI S Sbjct: 2185 WHKR------GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238 Query: 652 VIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISA--PSGG 709 VI P P + + + G L+L C + + W+ G + A G Sbjct: 2239 VI-PGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG----GSLPARHQVRG 2293 Query: 710 GASFNLSLTTEHSGIYSCEADNGLEAQRSEMVT----LKVAVPV-SRPVLTLRAPGTHAA 764 + + +G Y C A NG+EA + VT +A P S + + + A Sbjct: 2294 SRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA 2353 Query: 765 VGDLLELHC 773 G L+L+C Sbjct: 2354 EGQTLDLNC 2362 Score = 83.2 bits (204), Expect = 1e-15 Identities = 190/868 (21%), Positives = 299/868 (34%), Gaps = 110/868 (12%) Query: 23 PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQE--- 79 P I ++P + V +G+ + L C Q T W+ R + +L + + Sbjct: 2827 PPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT-WHKRGGNLPARHQVHGPLLRLNQVSP 2885 Query: 80 --SGEYRCQAQGSP-----------------------LSSPVHLDFSSASLILQAPLSVF 114 SGEY CQ GS L+ P++++ SS+ V Sbjct: 2886 ADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH--------VT 2937 Query: 115 EGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKR--TDFHIPHACLKDNGAYRCTGYKES 172 EG ++ L C + T YK L ++ + + D+G Y C Sbjct: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRA---- 2993 Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQ----PISGNPVTLTCET------QLSLERSDV 222 S + + T P SS++ IS +P + T + + + Sbjct: 2994 ---ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA 3050 Query: 223 PLRFRFFRDDQTLGLGWSLSPNFQI-TAMWSKDS--GFYWCKAATMPYSVISDSPRSWIQ 279 P+ + +Q L +SPN I T + ++ S G Y C A+ Y V +S + Sbjct: 3051 PISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNA-YGVA----QSVVN 3105 Query: 280 VQIPASHPVLTLSPEKALNFE-GTKVTLHC----ETQEDSLRTLYRFYHEGVPLRHKSVR 334 + + P +++ PE + + G VTL C E + + T + R + Sbjct: 3106 LSVHGP-PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLM 3164 Query: 335 CERGASISFSLTTENSGNYYCTADNGLGA--KPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392 S ++G Y C A N LG K + + + + P + E + Sbjct: 3165 DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE 3224 Query: 393 EGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADN 452 G TL C A P ++ + G I + + SG Y C A + Sbjct: 3225 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE--GDTLIIPRVAQQDSGQYICNATS 3282 Query: 453 GFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDM 512 G + + L V P P T A G TV L C + G+P + +Q+ Sbjct: 3283 PAGHAEATII-LHVESP---PYATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGS 3337 Query: 513 PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTL-- 570 L +T + F + E SG Y C N G + L P S P ++ Sbjct: 3338 SLPGRATARNELLHFERAAPED-SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPA 3396 Query: 571 -RVPRAQAV-------VGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL 622 P Q +G +E HC P L WF S G NL Sbjct: 3397 GSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNL 3456 Query: 623 SLTAEHSGNYSCEANNGL-VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCE 681 + + G Y C+A+ AQ S + + + V ++ R VVG +E C Sbjct: 3457 DQSCQ--GTYICQAHGPWGKAQASAQLVIQALPSV---LINIRTSVQTVVVGHAVEFECL 3511 Query: 682 ALRGSSPILYWFYHEDVTLGKISAPS---GGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738 AL P + W +G P GG + +G Y C A N +S Sbjct: 3512 ALGDPKPQVTWS-----KVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQS 3566 Query: 739 EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS 798 ++ L A+P +R P AAV C A G P + D +L S Sbjct: 3567 HVLLLVQALPQISMPQEVRVPAGSAAV-----FPCIA-SGYPTPDISWSKLDGSLPPDSR 3620 Query: 799 PSGGASLNLSLTAEHSGNYSCEADNGLG 826 + S+ + +G Y C A N G Sbjct: 3621 LENNMLMLPSVRPQDAGTYVCTATNRQG 3648 Score = 78.2 bits (191), Expect = 4e-14 Identities = 155/719 (21%), Positives = 258/719 (35%), Gaps = 72/719 (10%) Query: 162 GAYRCTG--------YKESCCPVSSNTVKIQV--------QEPFTRPVLRASSFQPISGN 205 G YRCT Y E C P +Q Q P V A S P G+ Sbjct: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693 Query: 206 PVTLTCETQLSLERSDVPLRFRFFRDD-QTLGLGWSL---SPNFQITAMWSKDSGFYWCK 261 +L C+ S P F + R+D + + G ++ D+G Y C Sbjct: 1694 H-SLRCQVSGS-----PPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICT 1747 Query: 262 AATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE-GTKVTLHCETQEDS--LRTL 318 + S + S + + P+ +T+ +++ + G VT C + S + Sbjct: 1748 CRNLHQS--NTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805 Query: 319 YRFYHEG-VPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKA-VSLSVTVP 376 + H G +P R G ++ ++G Y CT N A + + + Sbjct: 1806 WTRLHNGKLPTRAMDFN---GILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGT 1862 Query: 377 VSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISF 436 +S PV+++ P+ + G C A P L G L + A GG+ Sbjct: 1863 LSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAK-AQIHGGILRLP 1921 Query: 437 SLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEV 496 ++ Y C A + G Q ++AV L V P + +S G TV L+C Sbjct: 1922 AVEPTDQAQYLCRAHSSAGQQVARAV-LHVHGG-GGPRVQVSPERTQVHAGRTVRLYCRA 1979 Query: 497 QRGSPQILYQFYHE--DMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV 554 G P + E +P + S + ++T +G Y C A + G ++ + Sbjct: 1980 A-GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARI 2038 Query: 555 -VSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP 613 V + S P + + G L+L+C + + W+ G S P Sbjct: 2039 QVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR-----GGSLPP 2093 Query: 614 SGGEASFNLSL---TAEHSGNYSCEANNGLVAQHSDTISLSVI-----------VPVSRP 659 L L + SG Y C NG + + +I++SV+ VP S Sbjct: 2094 HTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEA-SITVSVLHGTHSGPSYTPVPGSTR 2152 Query: 660 ILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTT 719 + + G L+L+C + G + ++ +L G + +T Sbjct: 2153 PIRIEPSSSHVAEGQTLDLNC-VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLH-QVTP 2210 Query: 720 EHSGIYSCEA---DNGLEAQRSEMVTLKVAV-PVSRPVLTLRAPGTHAAVGDLLELHCEA 775 SG Y C LEA S +VT++ +V P P + + + + A G L+L C Sbjct: 2211 ADSGEYVCHVVGTSGPLEA--SVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC-V 2267 Query: 776 LRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVT 834 + G ++ +L R G + +G Y C A NG+ A + TVT Sbjct: 2268 VAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVT 2326 Score = 70.5 bits (171), Expect = 7e-12 Identities = 158/695 (22%), Positives = 242/695 (34%), Gaps = 120/695 (17%) Query: 8 LVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEIL 67 + + P G R P+I + PP +TV QG+ + C +P +W R Sbjct: 3007 VTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN------ 3060 Query: 68 RETPDNI-------------LEVQESGEYRCQAQGS--PLSSPVHLDFS---SASLILQA 109 +E DN+ G YRC A + S V+L + S++ + Sbjct: 3061 QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG 3120 Query: 110 PLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRT----DFH----IPHACLKDN 161 P+ V G +V L C + E + + + A L +RT D H I A D Sbjct: 3121 PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA 3180 Query: 162 GAYRCTGYKESCCPVSSNTVKIQVQEPFTRP-----VLRASSFQPISGNPVTLTCET--- 213 G Y C ++ + V++ V P + +G+ TL C Sbjct: 3181 GTYVCLA--QNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGS 3238 Query: 214 -----QLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYS 268 S RS +P + R D I + +DSG Y C A Sbjct: 3239 PAPTIHWSKLRSPLPWQHRLEGD------------TLIIPRVAQQDSGQYICNAT----- 3281 Query: 269 VISDSPRSWIQVQI---PASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEG 325 SP + I S P T PE A G V L C T +++ G Sbjct: 3282 ----SPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLT-FQWSRVG 3336 Query: 326 VPL------RHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSH 379 L R++ + ER A E+SG Y C N +G+ + A L P S Sbjct: 3337 SSLPGRATARNELLHFERAAP-------EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3389 Query: 380 PVLNL---SSPEDLIFE-------GAKVTLHCE--AQRGSLPILYQFHHEGAALERRSAN 427 P ++ S+P + GA V HC + RG+ ++ EG L + Sbjct: 3390 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQ---LRWFKEGGQLPPGHSV 3446 Query: 428 SAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEG 487 G + I +L G Y C A +G ++ A + +P ++ + ++ G Sbjct: 3447 QDGVLRIQ-NLDQSCQGTYICQAHGPWGKAQASAQLVIQALP--SVLINIRTSVQTVVVG 3503 Query: 488 ATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGF 547 V C + G P+ + L S G V + + +G Y CTA N Sbjct: 3504 HAVEFEC-LALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAH-VELADAGQYRCTATNAA 3561 Query: 548 GPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTL 607 G +S V+ L +P +RVP A V C A P + W + Sbjct: 3562 GTTQSHVLLLVQALPQISMPQEVRVPAGSAAV-----FPCIASGYPTPDISW------SK 3610 Query: 608 GSSSAPSGGEASFNL----SLTAEHSGNYSCEANN 638 S P N+ S+ + +G Y C A N Sbjct: 3611 LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATN 3645 Score = 55.8 bits (133), Expect = 2e-07 Identities = 114/506 (22%), Positives = 184/506 (36%), Gaps = 66/506 (13%) Query: 436 FSLTAEH--SGNYYCTADN-----------GFGPQRSKAVSLSVTVPVSHP---VLTLSS 479 FS T E +G Y CTA G G + +V +P ++ V+ + Sbjct: 1624 FSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHP 1683 Query: 480 AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF-SLTEGHSGN 538 A ++ +G + +L C+V P Y + P+ S + F S+ +G Sbjct: 1684 ARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGV 1743 Query: 539 YYCTADNGFGPQRSEVVSLFVTVPVSRPI-LTLRVPRAQAV-VGDLLELHCEAPRGSPPI 596 Y CT N S L VT S+PI +T+ R+Q+V G + C A SP Sbjct: 1744 YICTCRNLHQSNTSRA-ELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAY 1802 Query: 597 -LYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVA-QHSDTISLSVIV 654 L W + L + + G + ++ +G Y C +N Q + T+ + Sbjct: 1803 TLVWTRLHNGKLPTRAMDFNGILTIR-NVQLSDAGTYVCTGSNMFAMDQGTATLHVQASG 1861 Query: 655 PVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFN 714 +S P+++ P+ G L E C A +P L W L + GG Sbjct: 1862 TLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLP 1921 Query: 715 LSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPG----------THAA 764 T+ + Y C A + Q V+R VL + G T Sbjct: 1922 AVEPTDQAQ-YLCRAHSSAGQQ------------VARAVLHVHGGGGPRVQVSPERTQVH 1968 Query: 765 VGDLLELHCEALR-GSPLILYRFFHEDVTLGNRSSPSGGASLNL-SLTAEHSGNYSCEAD 822 G + L+C A S I +R + RS + A+L + ++T +G Y C A Sbjct: 1969 AGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVAT 2028 Query: 823 NGLGAQRSETVTLYITGLTAN-------RSGPFATGVAGGLLSIAGLAAGALLLYCWLSR 875 + G ++ + ++ A+ S P T G L + + AG+ R Sbjct: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT--EGQTLDLNCVVAGSAHAQVTWYR 2086 Query: 876 KAGRKPASD---------PARSPSDS 892 + G P P SP+DS Sbjct: 2087 RGGSLPPHTQVHGSRLRLPQVSPADS 2112 >gi|189083840 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) isoform c precursor [Homo sapiens] Length = 254 Score = 107 bits (266), Expect = 7e-23 Identities = 89/269 (33%), Positives = 127/269 (47%), Gaps = 31/269 (11%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58 +LL LL+L + P+ ++FL+P W V + + VTL C+G YSP+ T+W+ Sbjct: 4 LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQWF 61 Query: 59 HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114 H + ++ + V +SGEYRCQ S LS PV L+ L+LQAP VF Sbjct: 62 H---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 118 Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172 E D + LRC + L+ Y +N + + +DF+IP A LKD+G+Y C G S Sbjct: 119 KEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGS 178 Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232 VSS TV I + + V SSF P G V+ C + L D Sbjct: 179 -KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT---------- 223 Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWCK 261 GL +S+ N + + KD F W K Sbjct: 224 ---GLYFSVKTNIRSSTRDWKDHKFKWRK 249 Score = 32.7 bits (73), Expect = 1.7 Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 18/181 (9%) Query: 113 VFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171 V E DSV L+C+ N+T + N+++++ ++ + + I A + D+G YRC + Sbjct: 37 VLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQASSYFIDAATVDDSGEYRC----Q 90 Query: 172 SCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD 231 + S+ V+++V + +L+A + +P+ L C + + V + Sbjct: 91 TNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVT-----YLQ 143 Query: 232 DQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291 + + + +F I KDSG Y+C+ +V S++ + + I V T+ Sbjct: 144 NGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSET----VNITITQGLAVSTI 199 Query: 292 S 292 S Sbjct: 200 S 200 >gi|189083838 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) isoform c precursor [Homo sapiens] Length = 254 Score = 107 bits (266), Expect = 7e-23 Identities = 89/269 (33%), Positives = 127/269 (47%), Gaps = 31/269 (11%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58 +LL LL+L + P+ ++FL+P W V + + VTL C+G YSP+ T+W+ Sbjct: 4 LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQWF 61 Query: 59 HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114 H + ++ + V +SGEYRCQ S LS PV L+ L+LQAP VF Sbjct: 62 H---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 118 Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172 E D + LRC + L+ Y +N + + +DF+IP A LKD+G+Y C G S Sbjct: 119 KEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGS 178 Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232 VSS TV I + + V SSF P G V+ C + L D Sbjct: 179 -KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT---------- 223 Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWCK 261 GL +S+ N + + KD F W K Sbjct: 224 ---GLYFSVKTNIRSSTRDWKDHKFKWRK 249 Score = 32.7 bits (73), Expect = 1.7 Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 18/181 (9%) Query: 113 VFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171 V E DSV L+C+ N+T + N+++++ ++ + + I A + D+G YRC + Sbjct: 37 VLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQASSYFIDAATVDDSGEYRC----Q 90 Query: 172 SCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD 231 + S+ V+++V + +L+A + +P+ L C + + V + Sbjct: 91 TNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVT-----YLQ 143 Query: 232 DQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291 + + + +F I KDSG Y+C+ +V S++ + + I V T+ Sbjct: 144 NGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSET----VNITITQGLAVSTI 199 Query: 292 S 292 S Sbjct: 200 S 200 >gi|189083836 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) isoform b precursor [Homo sapiens] Length = 289 Score = 107 bits (266), Expect = 7e-23 Identities = 89/272 (32%), Positives = 129/272 (47%), Gaps = 35/272 (12%) Query: 2 LLWVILL----VLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KT 55 ++W +LL +L +G P+ ++FL+P W V + + VTL C+G YSP+ T Sbjct: 36 IMWQLLLPTALLLLVSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNST 93 Query: 56 KWYHRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPL 111 +W+H + ++ + V +SGEYRCQ S LS PV L+ L+LQAP Sbjct: 94 QWFH---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPR 150 Query: 112 SVF-EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGY 169 VF E D + LRC + L+ Y +N + + +DF+IP A LKD+G+Y C G Sbjct: 151 WVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGL 210 Query: 170 KESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFF 229 S VSS TV I + + V SSF P G V+ C + L D Sbjct: 211 FGS-KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT------- 258 Query: 230 RDDQTLGLGWSLSPNFQITAMWSKDSGFYWCK 261 GL +S+ N + + KD F W K Sbjct: 259 ------GLYFSVKTNIRSSTRDWKDHKFKWRK 284 Score = 33.5 bits (75), Expect = 1.00 Identities = 44/203 (21%), Positives = 91/203 (44%), Gaps = 19/203 (9%) Query: 92 LSSPVHLDFSSASLILQAP-LSVFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRT 149 +S+ + D A + L+ V E DSV L+C+ N+T + N+++++ ++ + Sbjct: 50 VSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQAS 107 Query: 150 DFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTL 209 + I A + D+G YRC ++ S+ V+++V + +L+A + +P+ L Sbjct: 108 SYFIDAATVDDSGEYRC----QTNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHL 161 Query: 210 TCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSV 269 C + + V + + + + +F I KDSG Y+C+ +V Sbjct: 162 RCHSWKNTALHKVT-----YLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNV 216 Query: 270 ISDSPRSWIQVQIPASHPVLTLS 292 S++ + + I V T+S Sbjct: 217 SSET----VNITITQGLAVSTIS 235 >gi|50726979 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) isoform a precursor [Homo sapiens] Length = 290 Score = 107 bits (266), Expect = 7e-23 Identities = 89/269 (33%), Positives = 127/269 (47%), Gaps = 31/269 (11%) Query: 1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTKWY 58 +LL LL+L + P+ ++FL+P W V + + VTL C+G YSP+ T+W+ Sbjct: 40 LLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQWF 97 Query: 59 HRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVF 114 H + ++ + V +SGEYRCQ S LS PV L+ L+LQAP VF Sbjct: 98 H---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF 154 Query: 115 -EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172 E D + LRC + L+ Y +N + + +DF+IP A LKD+G+Y C G S Sbjct: 155 KEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGS 214 Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232 VSS TV I + + V SSF P G V+ C + L D Sbjct: 215 -KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT---------- 259 Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWCK 261 GL +S+ N + + KD F W K Sbjct: 260 ---GLYFSVKTNIRSSTRDWKDHKFKWRK 285 Score = 32.7 bits (73), Expect = 1.7 Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 18/181 (9%) Query: 113 VFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE 171 V E DSV L+C+ N+T + N+++++ ++ + + I A + D+G YRC + Sbjct: 73 VLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQASSYFIDAATVDDSGEYRC----Q 126 Query: 172 SCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD 231 + S+ V+++V + +L+A + +P+ L C + + V + Sbjct: 127 TNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHLRCHSWKNTALHKVT-----YLQ 179 Query: 232 DQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTL 291 + + + +F I KDSG Y+C+ +V S++ + + I V T+ Sbjct: 180 NGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSET----VNITITQGLAVSTI 235 Query: 292 S 292 S Sbjct: 236 S 236 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 107 bits (266), Expect = 7e-23 Identities = 197/818 (24%), Positives = 319/818 (38%), Gaps = 121/818 (14%) Query: 74 ILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSV-----------FEGDSVVLR 122 +L V+++G Y C A+ SP S + +QAP ++ +VL Sbjct: 2357 VLRVRDAGLYTCLAE-----SPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE 2411 Query: 123 CRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV 176 C +AE T +++ VL F + + D+G Y CT + Sbjct: 2412 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA---- 2467 Query: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL---ERSDVPLRFRFFRDDQ 233 S +V +V E T P +R SG P Q +L + VP +R D+ Sbjct: 2468 GSTSVAFRV-EIHTVPTIR-------SGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 2519 Query: 234 T----LGLGWSLSP--NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP 287 + + P + +I + ++D+G Y C A+ S SD ++V P P Sbjct: 2520 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN---SAGSDRQGRDLRVLEP---P 2573 Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGA-----SIS 342 + SP T L CE S + L ++ +G L R ++GA S + Sbjct: 2574 AIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKL---DFRLQQGAYRLLPSNA 2629 Query: 343 FSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399 LT ++S + C N +G + + ++V VP P + + + A V L Sbjct: 2630 LLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVHVP---PTIADDQTDFTVTMMAPVVL 2685 Query: 400 HCEAQRGSLPILYQFHHEGAALERRSA----NSAGGVAISFSLTAEHSGNYYCTADNGFG 455 C + P + + GA L R + + +G + I +L H+G Y C+A N G Sbjct: 2686 TCHSTGIPAPTV-SWSKAGAQLGARGSGYRVSPSGALEIGQALPI-HAGRYTCSARNSAG 2743 Query: 456 PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515 PV P+ ++ A A V L CE G P+ + E + + Sbjct: 2744 VAHKHVFLTVQASPVVKPLPSVVRAVA----EEEVLLPCEAS-GIPRPTITWQKEGLNVA 2798 Query: 516 SSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572 + + V G++ + + E +GNY C A N G + L V VP P++ + Sbjct: 2799 TGVSTQVLPGGQLRIAHASPED-AGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGL 2853 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-SGGEASFNL--------- 622 P G L C+A RGSP ++T P SG E F + Sbjct: 2854 PDLSTTEGSHAFLPCKA-RGSP-------EPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2905 Query: 623 SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 +L + +G Y+C A N V + + L+++V P+ T +GD L L C A Sbjct: 2906 NLEGQDAGTYTCTAENA-VGRARRRVHLTILV---LPVFTTLPGDRSLRLGDRLWLRCAA 2961 Query: 683 LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL-EAQRSEMV 741 +P + W ++ +S GG +++ E SG Y C A+N + Q V Sbjct: 2962 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021 Query: 742 TLKVAVPVSRPVLTLRA-PGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800 +K A PVL A VG ++L C +RG P+ + + + L R S Sbjct: 3022 HVKEA-----PVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDIHWIKDGLPL--RGSHL 3073 Query: 801 GGASLNLSLT-----AEHSGNYSCEADNGLGAQRSETV 833 N SLT + +G Y C A+N +G + + Sbjct: 3074 RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVI 3111 Score = 106 bits (264), Expect = 1e-22 Identities = 207/857 (24%), Positives = 326/857 (38%), Gaps = 83/857 (9%) Query: 19 RTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY----LGKEILRETPDNI 74 + P I L T V+L C +P+ T WY LG+E+ + Sbjct: 1743 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT-WYKDSQALSLGEEVFLLPGTHT 1801 Query: 75 LEV-----QESGEYRCQAQGSP--------LSSPVHLDFSSASLILQAPLSVFEGDSVVL 121 L++ +SG Y C+A + LS V F A Q + V GD VL Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1861 Query: 122 RCRAKAEVTLNNTIYKNDNVLAFLNKRTD-------FHIPHACLKDNGAYRCTGYKESCC 174 C A T YK+ L L +RT I A + D G Y C + Sbjct: 1862 SCETDALPEPTVTWYKDGQPLV-LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1920 Query: 175 PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 V + T+ +QV F P + + ++G+P+ LTC+ + L+ R + Sbjct: 1921 AVRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA 1978 Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294 + S Q++ + +G Y C A + +++ + ++ + A + Sbjct: 1979 VHGVVSRGGRLQLSRLQPAQAGTYTCVAE----NTQAEARKDFVVAVLVAPRIRSSGVAR 2034 Query: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-----RHKSVRCERGASISFSLTTEN 349 + EG +V L CE + + +G PL H + G+ + L + Sbjct: 2035 EHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2093 Query: 350 SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLP 409 +G Y C A N G + ++ +++V VP + S + G VT+ C RGS P Sbjct: 2094 AGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPP 2151 Query: 410 ILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466 I + +G L +R + +G + +G + C A + G + +L V Sbjct: 2152 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQV 2210 Query: 467 TV-PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRV 525 V PV PV + + + G+ V L CE RG P L + + PL S S + Sbjct: 2211 QVPPVLEPVEFQN--DVVVVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLEQGPSL 2267 Query: 526 SFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV-GDLLE 584 ++ G SG Y C A + G R +TV I P ++ G +E Sbjct: 2268 QLE-AVGAGDSGTYSCVAVSEAGEARRH---FQLTVMEPPHIEDSGQPTELSLTPGAPME 2323 Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644 L C+A P + W H+D G + + L +G Y+C L Sbjct: 2324 LLCDAQGTPQPNITW--HKD---GQALTRLENNSRATRVLRVRDAGLYTC-----LAESP 2373 Query: 645 SDTISLSVIVPVSRP--ILTFRAPR-AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701 + I S V V P I+ R PR + L L C +P + W H D + Sbjct: 2374 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW--HRDGIVL 2431 Query: 702 KISA----PSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757 + A P G +L+T SG YSC A N A S V +V + + P + Sbjct: 2432 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARN---AAGSTSVAFRVEIH-TVPTIRSG 2487 Query: 758 APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLTAE 812 P + +V L C+A G P L + + V L RS P G + + A+ Sbjct: 2488 PPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ-PVLAQ 2545 Query: 813 HSGNYSCEADNGLGAQR 829 +G+Y C A N G+ R Sbjct: 2546 DAGHYLCLASNSAGSDR 2562 Score = 92.8 bits (229), Expect = 1e-18 Identities = 213/899 (23%), Positives = 324/899 (36%), Gaps = 141/899 (15%) Query: 34 VFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRE-----TPDNIL------EVQESGE 82 V G+ L C P+ T W+ G+ + R +PD +L + +G Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLT-WFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGH 1322 Query: 83 YRCQAQGSPLSSPVHLDFSSASLILQAP-------------LSVFEGDSVVLRCRAKAEV 129 Y C A + H S +L AP ++V + + L C A A Sbjct: 1323 YSCIAANAVGEKTKHFQLS----VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 1378 Query: 130 TLNNTIYKN------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + N T K+ + L I +A +D G Y C E V + V++ Sbjct: 1379 SPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1438 Query: 184 QVQEPFTRP----VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ------ 233 + ++ + + + +TL CE+ + P R+++D Q Sbjct: 1439 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW-----AVPPPTIRWYKDGQPVTPSS 1493 Query: 234 ---TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQV-QIP 283 LG G L QI DSG Y C A + ++V+ P + +V Sbjct: 1494 RLQVLGEGRLL----QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 1549 Query: 284 ASHPVLTLSPEKALNF-------EGTKVTLHCETQEDSLRTLYRFYHEGVPLR---HKSV 333 A+ +L+ E E L+C+T L +Y E PL SV Sbjct: 1550 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSV 1608 Query: 334 RCERGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392 + G + L EN+G Y C A N +G L +T PV L E+L+ Sbjct: 1609 -LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-----LGDTEELVE 1662 Query: 393 E-----GAKVTLHCEAQRGSLPILYQFHH--EGAALERRSANSAGGVAISFSLTAEHSGN 445 E + V+L C A +P + + + R G V + + + Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1722 Query: 446 YYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSPQIL 504 Y C A+N G K +L V VP L L A+ ++V+L C+V +P++ Sbjct: 1723 YMCVAENQAG-SAEKLFTLRVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 1779 Query: 505 Y-------QFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSL 557 + E L + T +GR S SG Y C A N G + ++V L Sbjct: 1780 WYKDSQALSLGEEVFLLPGTHTLQLGRARLS------DSGMYTCEALNAAG-RDQKLVQL 1832 Query: 558 FVTVPVSRPILTLRVPRA--QAV---VGDLLELHCEAPRGSPPILYWFYHED--VTLGSS 610 V VP + + PR AV VGD L CE P + W+ V + Sbjct: 1833 SVLVPPA----FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 1888 Query: 611 SAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQA 670 A GG+ G YSC+ +N + + T +L+V VP TF P+ + Sbjct: 1889 QALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTVQVPP-----TFENPKTET 1942 Query: 671 ---VVGDLLELHCEALRGSSPILYWFYHE-DVTLGKISAPSGGGASFNLS-LTTEHSGIY 725 V G L L C+ +P + W V + G LS L +G Y Sbjct: 1943 VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTY 2002 Query: 726 SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785 +C A+N R + V + P R R H G + L CEA G P Sbjct: 2003 TCVAENTQAEARKDFVVAVLVAPRIRSSGVARE--HHVLEGQEVRLDCEA-DGQPPPDVA 2059 Query: 786 FFHEDVTLGNRSSP------SGGASLNLSLTAEHSGNYSCEADNGLGAQ-RSETVTLYI 837 + + LG P GG+ + L A +G Y+C A N G R TV + + Sbjct: 2060 WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 2118 Score = 90.1 bits (222), Expect = 9e-18 Identities = 203/898 (22%), Positives = 328/898 (36%), Gaps = 136/898 (15%) Query: 40 VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNIL------------EVQESGEYRCQA 87 +TL C+ P +W+ G+E + D L + Q+SG Y C A Sbjct: 1179 LTLLCEAMGI-PPPAIRWFR---GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1234 Query: 88 QGSPLSSPVHLDFSSASLI--------LQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKND 139 + +FS L+ L+ + V +G + L C T +K+ Sbjct: 1235 SNE--AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 1292 Query: 140 NVLAFLNKRTDFH----------IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPF 189 LA R D H + A L G Y C V T Q+ Sbjct: 1293 RPLA----RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLL 1344 Query: 190 TRPVLRA---SSFQPIS---GNPVTLTCET------QLSLERSDVPLRFRFFRDDQTLGL 237 +L S+ + ++ NP++L CE ++ + P F R+ Q L Sbjct: 1345 APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPG 1402 Query: 238 GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPAS----HPVLTLS 292 L QI +D+G Y C + + ++ +++ ++V IP S P+ + Sbjct: 1403 THGL----QILNAQKEDAGQYTCVVT----NELGEAVKNYHVEVLIPPSISKDDPLGEVG 1454 Query: 293 PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLT---TEN 349 ++ + +TL CE+ T+ R+Y +G P+ S G + + Sbjct: 1455 VKEVKTKVNSTLTLECESWAVPPPTI-RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSD 1513 Query: 350 SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------------IFE 393 SG Y C A N G L P+ V + S+ ++ I E Sbjct: 1514 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 1573 Query: 394 GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAEHSGNYYCTAD 451 L+C+ P L + + +A + S G V + AE++G Y C A Sbjct: 1574 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1633 Query: 452 NGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFE-----GATVTLHCEVQRGSPQILYQ 506 N G L +T PV L E L E +TV+L C G+P Sbjct: 1634 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTIS 1687 Query: 507 FYHEDMPLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPV 563 + +P S V G+V + + +Y C A+N G ++ +L V VP Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG-SAEKLFTLRVQVPP 1746 Query: 564 SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHED-VTLGSSSAPSGGEASFNL 622 I L + + A++ + L C+ P + W+ ++LG G + L Sbjct: 1747 R--IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 1804 Query: 623 SLTA-EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR-APRA--QAV---VGDL 675 SG Y+CEA N + + LSV+VP + FR APR AV VGD Sbjct: 1805 GRARLSDSGMYTCEALNA-AGRDQKLVQLSVLVPPA-----FRQAPRGPQDAVLVRVGDK 1858 Query: 676 LELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLS-LTTEHSGIYSCEADNGL 733 L CE P + W+ + + L + + GG + G+YSC+ N Sbjct: 1859 AVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVA 1918 Query: 734 -EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 EA R+ +T++V P + G L L C+ + G P + + + Sbjct: 1919 GEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCD-VSGVPAPTVTWLKDRMP 1973 Query: 793 LGNRSSP---SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSG 846 + + + S G L LS L +G Y+C A+N R + V + SG Sbjct: 1974 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG 2031 Score = 79.3 bits (194), Expect = 2e-14 Identities = 102/392 (26%), Positives = 160/392 (40%), Gaps = 27/392 (6%) Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 E++GNY C A N G+ K L V VP PV+ P+ EG+ L C+A RGS Sbjct: 2819 EDAGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGLPDLSTTEGSHAFLPCKA-RGS 2873 Query: 408 LPILYQFHHEG---AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464 + +G + E + G + +L + +G Y CTA+N G R + V L Sbjct: 2874 PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR-VHL 2932 Query: 465 SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGR 524 ++ V PV T + G + L C RGSP + D P+ + G Sbjct: 2933 TILVL---PVFTTLPGDRSLRLGDRLWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDGG 2988 Query: 525 VSFS-FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583 + +++ SG Y C A+N G R++ VS FV V + + VG + Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVG--RTQAVS-FVHVKEAPVLQGEAFSYLVEPVGGSI 3045 Query: 584 ELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGL- 640 +L C RG P P ++W GS S + T + +G Y C A N + Sbjct: 3046 QLDCVV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMG 3104 Query: 641 VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFY-HEDVT 699 VA+ + ++V S P+ GD + L C+A +P + W + + Sbjct: 3105 VAK-----KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR 3159 Query: 700 LGKISAPSGGGASFNLSLTTEHSGIYSCEADN 731 + G+ + ++ T +G Y C A N Sbjct: 3160 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3191 Score = 77.0 bits (188), Expect = 8e-14 Identities = 211/869 (24%), Positives = 301/869 (34%), Gaps = 122/869 (14%) Query: 37 GERVTLTCKGFRFYSPQKTKWYHRYL----GKEILRETPDNILEVQESGEYRCQAQGSPL 92 G V L C SP + W+H L E ET ++L ++ GE Sbjct: 420 GRPVALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478 Query: 93 SSPVHLDFSSASLILQAP-----------LSVFEGDSVVLRCRAKAEVTLNNTIYKNDNV 141 SSP S+ +Q P ++ G + L C+A +N Sbjct: 479 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538 Query: 142 LAFL------NKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLR 195 L ++ T HI H L +G + C E+ + V++ V + VL Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA--GTAGAEVEVSVHGEWAPGVLE 596 Query: 196 ASSFQPISG----NPVTLTCETQLSLERSDVPLR---------FRFFRDDQTLGLGWSLS 242 Q G + C+ + P + + + + +SL Sbjct: 597 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 656 Query: 243 PNFQITAMWSKDSGFYWCKAATMPYSVISDSPRS-WIQVQIPASHPVLTLSPEKALNFEG 301 P QI + +D G Y C A ++ +S R ++V +P P + P E Sbjct: 657 PPLQIEKVDLRDEGIYTCAAT----NLAGESKREVALKVLVP---PNIEPGPVNKAVLEN 709 Query: 302 TKVTLHCETQEDSLRTLYRFYHEGVP-------LRHKSVRCERGASISF--------SLT 346 VTL C GVP H+ V G ++S Sbjct: 710 ASVTLEC-------------LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQ 756 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNL-SSPEDLIFEGAKVTLHCEAQR 405 ++G+Y C A N G+ + L V VP P + L S + V L C A Sbjct: 757 LSDAGSYRCVASNVAGSTELR-YGLRVNVP---PRITLPPSLPGPVLVNTPVRLTCNATG 812 Query: 406 GSLPILYQFHH----EGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKA 461 P L A G V S A SG Y C A + G R Sbjct: 813 APSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 872 Query: 462 VSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPS 521 V L V +P P + +V L C+ P +L ++ + PL P Sbjct: 873 V-LQVHMP---PSILGEELNVSVVANESVALECQSHAMPPPVL-SWWKDGRPL--EPRPG 925 Query: 522 VGRVSFSFSLTE------GHSGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRVPR 574 V +S +L + +G+Y C A N G RSE +L V V P+ LR Sbjct: 926 V-HLSADKALLQVDRADVWDAGHYTCEALNQAG--RSEKHYNLNVWV---APVFPLRESH 979 Query: 575 AQAV-VGDLLELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTAE----H 628 V G L CE RG P P + W G + A L + Sbjct: 980 TLTVREGHPTSLSCEC-RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ 1038 Query: 629 SGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQ-AVVGD-LLELHCEALRGS 686 G Y+CE +N +V S + L V VP I R P Q +VV D + L C A Sbjct: 1039 EGTYTCECSN-VVGNSSQDLQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKP 1095 Query: 687 SPILYWFYHEDVTLGKISAP-SGGGASFNLS-LTTEHSGIYSCEADNGLEAQRSEMVTLK 744 P + W ++ G S ++ H+G YSC A+N L + L Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELS 1154 Query: 745 VAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFF--HEDVTLGNRS-SPSG 801 V VP AA+ L L CEA+ G P R+F E V+ G + +G Sbjct: 1155 VLVPPELIGDLDPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGEEPVSPGEDTYLLAG 1213 Query: 802 GASLNLSLTAEH-SGNYSCEADNGLGAQR 829 G L ++ T E SG YSC A N G R Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEAR 1242 Score = 75.9 bits (185), Expect = 2e-13 Identities = 185/837 (22%), Positives = 291/837 (34%), Gaps = 141/837 (16%) Query: 79 ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEV 129 +SG Y C A S V D L + P +SV +SV L C++ A Sbjct: 853 DSGRYSCVAV-----SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMP 907 Query: 130 TLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + +K+ L + + A + D G Y C ++ + + Sbjct: 908 PPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967 Query: 184 QVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTL-GLGWSL 241 V F P+ + + G+P +L+CE + VP + + +D Q L G G L Sbjct: 968 WVAPVF--PLRESHTLTVREGHPTSLSCECR------GVPFPKISWRKDGQPLPGEGAGL 1019 Query: 242 SPNFQITAMWS------KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEK 295 + + G Y C+ + + V + S ++V +P P + Sbjct: 1020 QHVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQ 1076 Query: 296 ALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE------- 348 + TL C T+ + +G P+ GA + L + Sbjct: 1077 VSVVQDGVATLECNATGKPPPTV-TWERDGQPV---------GAELGLQLQNQGQSLHVE 1126 Query: 349 -----NSGNYYCTADNGLGAKPSKAVSLSVTVPVS-----HPVLNLSSPEDLIFEGAKVT 398 ++G Y C A+N L + + LSV VP P+ N+++ + +T Sbjct: 1127 RAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPELIGDLDPLTNITAALH-----SPLT 1180 Query: 399 LHCEAQRGSLPILYQFHHEGAALERRSANS-AGGVAISFSLTAEH-SGNYYCTADNGFGP 456 L CEA P + F E AGG + + T E SG Y C A N G Sbjct: 1181 LLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE 1240 Query: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516 R + S+ V VP S L + +G T L C V G PQ ++ + PL Sbjct: 1241 AR-RNFSVEVLVPPSIENEDLEEVIKV-LDGQTAHLMCNVT-GHPQPKLTWFKDGRPLAR 1297 Query: 517 SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572 + + + + +G+Y C A N G + +S+ + + Sbjct: 1298 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1357 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTA------ 626 V + + L CEA P + W AP EAS N+ L Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWM--------KDGAPF--EASRNIQLLPGTHGLQ 1407 Query: 627 ------EHSGNYSCEANNGLVAQHSDTISLSVIVPVS----RPILTFRAPRAQAVVGDLL 676 E +G Y+C N L + + V++P S P+ + V L Sbjct: 1408 ILNAQKEDAGQYTCVVTNEL-GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTL 1466 Query: 677 ELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLSLT-TEHSGIYSCEADNGLE 734 L CE+ P + W+ + VT G G + T SG Y C A N Sbjct: 1467 TLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1526 Query: 735 AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG----------SPLILY 784 + L P+ + V G +A ++L EA G +P LY Sbjct: 1527 EDDQDFNVLIQVPPMFQKV------GDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580 Query: 785 -----------RFFHEDVTLGNRSSPS---GGASLNLSLT-AEHSGNYSCEADNGLG 826 ++ ED L S GG L + L AE++G YSC+A N +G Sbjct: 1581 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1637 Score = 73.2 bits (178), Expect = 1e-12 Identities = 137/528 (25%), Positives = 193/528 (36%), Gaps = 69/528 (13%) Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE---GAKVTLHCEA 403 + ++G Y C A N +GA KA L V VP P + + + + G V L C A Sbjct: 374 SSDAGVYTCKASNAVGAA-EKATRLDVYVP---PTIEGAGGRPYVVKAVAGRPVALECVA 429 Query: 404 QRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAE-HSGNYYCTADNGFGPQRSK 460 + P L +HHEG A S G + E SG Y C A + P Sbjct: 430 RGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASS---PAGEA 485 Query: 461 AVSLSVTVPVSHPVLTLSS-AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP---LWS 516 + SV V V +L + T G + L C+ GSP Q+ P L Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS-GSPVPTIQWLQNGRPAEELAG 544 Query: 517 SSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQ 576 S G + HSG + C A N G +EV V+V L VP Q Sbjct: 545 VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVE---VSVHGEWAPGVLEVPIGQ 601 Query: 577 AVVGDLLELHCEAPRGSPPILY--WFYHEDVTLGSS--------SAPSGGEASFNL---- 622 G E H P P ++ W H L P+G +++L Sbjct: 602 YHWGX--EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPL 659 Query: 623 ---SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDL-LEL 678 + G Y+C A N L + ++L V+VP + P +AV+ + + L Sbjct: 660 QIEKVDLRDEGIYTCAATN-LAGESKREVALKVLVPPNIE----PGPVNKAVLENASVTL 714 Query: 679 HCEALRGSSPILYWFY-HEDVTLGKISAPSGGGASFNLSLTT-EHSGIYSCEADNGLEAQ 736 C A P + WF H+ V+ S G + +G Y C A N + Sbjct: 715 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGS 773 Query: 737 RSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG-SPLILYRFFHEDVTLGN 795 L+V VP R L PG V + L C A SP +++ + GN Sbjct: 774 TELRYGLRVNVP-PRITLPPSLPGP-VLVNTPVRLTCNATGAPSPTLMW------LKDGN 825 Query: 796 RSSPSGGASLNL----------SLTAEHSGNYSCEADNGLGAQRSETV 833 SP+G L + S A SG YSC A + +G R + V Sbjct: 826 PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873 Score = 69.7 bits (169), Expect = 1e-11 Identities = 113/488 (23%), Positives = 193/488 (39%), Gaps = 39/488 (7%) Query: 162 GAYRCTGYKESCCPVSSNTVKIQVQ-EPFTRPVLRASSFQPISGNPVTLTCETQLSLERS 220 G Y C+ + V+ V + VQ P +P+ S + ++ V L CE + R Sbjct: 2732 GRYTCSA--RNSAGVAHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEAS-GIPRP 2786 Query: 221 DVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWI 278 + + + G+ + P Q+ + +D+G Y C A S + ++ + Sbjct: 2787 TITWQKEGL--NVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMG---KTRL 2841 Query: 279 QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRC 335 VQ+P PV+ EG+ L C+ + S + +G P+ K Sbjct: 2842 VVQVP---PVIENGLPDLSTTEGSHAFLPCKAR-GSPEPNITWDKDGQPVSGAEGKFTIQ 2897 Query: 336 ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395 G + +L +++G Y CTA+N +G + + V L++ V PV + + G Sbjct: 2898 PSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVL---PVFTTLPGDRSLRLGD 2953 Query: 396 KVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG 455 ++ L C A+ P + ++ E S G +++ E SG Y C A+N G Sbjct: 2954 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 3013 Query: 456 PQRSKAVSLSVTVPVSHPVLTLSSAEALTFE--GATVTLHCEVQRGSPQILYQFYHEDMP 513 R++AVS V V + A + E G ++ L C V RG P + + +P Sbjct: 3014 --RTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLP 3067 Query: 514 LWSSSTP-SVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLR 571 L S + S + TE +G Y C A+N G + V + V S P+ + Sbjct: 3068 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV----ILVLQSAPVFQVE 3123 Query: 572 VPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL-SLTAEHSG 630 GD + L C+A P + W S + + S L ++ +G Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3183 Query: 631 NYSCEANN 638 Y C A+N Sbjct: 3184 TYDCVAHN 3191 Score = 57.8 bits (138), Expect = 5e-08 Identities = 151/638 (23%), Positives = 239/638 (37%), Gaps = 97/638 (15%) Query: 246 QITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVT 305 Q+ S D+G Y CKA+ +V + + + V +P + P G V Sbjct: 368 QLGRAQSSDAGVYTCKASN---AVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVA 424 Query: 306 LHCETQEDSLRTLYRFYHEGVPLRHKS-VRCERGASI--SFSLTTENSGNYYCTADNGLG 362 L C + TL ++HEG+P+ + R E S+ S +SG Y C A + G Sbjct: 425 LECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 483 Query: 363 AKPSKAVSLSVTVPVSHPVL---NLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGA 419 + SV V V +L L ++ G + L C+A +P + Q+ G Sbjct: 484 ---EAVLQYSVEVQVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTI-QWLQNG- 536 Query: 420 ALERRSANSAGGVAISFSLTA--------EHSGNYYCTADNGFGPQRSKAVSLSVTVPVS 471 R A GV ++ T +HSG + C A N G ++ V +SV + Sbjct: 537 ----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE-VEVSVHGEWA 591 Query: 472 HPVLTLSSAEAL--TFEGATVTLHCE--VQRG----SPQILYQFYHEDMPLWSSSTPSVG 523 VL + + ++ C+ V RG L + + LW T Sbjct: 592 PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPT---- 647 Query: 524 RVSFSFSLTE---------GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPR 574 + ++SL G Y C A N G + EV + P P P Sbjct: 648 GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP-----GPV 702 Query: 575 AQAVVGDL-LELHCEAPRGSPPILYWFY-HEDVT--LGSSSAPSGGEASFNLSLTAEHSG 630 +AV+ + + L C A PP + WF H+ V+ +G + + G + ++ +G Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSD-AG 761 Query: 631 NYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPIL 690 +Y C A+N S + + V V I + +V + L C A SP L Sbjct: 762 SYRCVASN---VAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTL 818 Query: 691 YWFYHEDVTLGKISAPSG--------GGASFNL-SLTTEHSGIYSCEADNGLEAQRSEMV 741 W G +P+G GG L S SG YSC A + + R ++V Sbjct: 819 MWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873 Query: 742 TLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSG 801 L+V +P P + + + L C++ P +L + +D G P Sbjct: 874 -LQVHMP---PSILGEELNVSVVANESVALECQSHAMPPPVL--SWWKD---GRPLEPRP 924 Query: 802 GASLNLS--------LTAEHSGNYSCEADNGLGAQRSE 831 G L+ +G+Y+CEA N G RSE Sbjct: 925 GVHLSADKALLQVDRADVWDAGHYTCEALNQAG--RSE 960 Score = 40.8 bits (94), Expect = 0.006 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 40/314 (12%) Query: 75 LEVQESGEYRCQAQGSP--LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVT 130 LE Q++G Y C A+ + VHL + P S+ GD + LRC A+ T Sbjct: 2907 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 2966 Query: 131 LNNTIYKNDNVLAFLNKRTD----FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQ 186 ND + D +D+G Y C + E+ + + V+ Sbjct: 2967 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC--WAENRVGRTQAVSFVHVK 3024 Query: 187 EPFTRPVLRASSF----QPISGNPVTLTCETQ------LSLERSDVPLRFRFFRDDQTLG 236 E PVL+ +F +P+ G+ + L C + + + +PLR R G Sbjct: 3025 EA---PVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG 3080 Query: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296 + I D+G Y C A + + + S PV + P+ Sbjct: 3081 -------SLTIHRTERDDAGRYQCLAEN------EMGVAKKVVILVLQSAPVFQVEPQDM 3127 Query: 297 LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRCERGASISF-SLTTENSGNYY 354 G V L C+ + T+ + G PLR + +R S+ ++ T ++G Y Sbjct: 3128 TVRSGDDVALRCQATGEPTPTI-EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 3186 Query: 355 CTADNGLGAKPSKA 368 C A N LG+ ++A Sbjct: 3187 CVAHNLLGSATARA 3200 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 107 bits (266), Expect = 7e-23 Identities = 197/818 (24%), Positives = 319/818 (38%), Gaps = 121/818 (14%) Query: 74 ILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSV-----------FEGDSVVLR 122 +L V+++G Y C A+ SP S + +QAP ++ +VL Sbjct: 3548 VLRVRDAGLYTCLAE-----SPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE 3602 Query: 123 CRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV 176 C +AE T +++ VL F + + D+G Y CT + Sbjct: 3603 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA---- 3658 Query: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL---ERSDVPLRFRFFRDDQ 233 S +V +V E T P +R SG P Q +L + VP +R D+ Sbjct: 3659 GSTSVAFRV-EIHTVPTIR-------SGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 3710 Query: 234 T----LGLGWSLSP--NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP 287 + + P + +I + ++D+G Y C A+ S SD ++V P P Sbjct: 3711 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN---SAGSDRQGRDLRVLEP---P 3764 Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGA-----SIS 342 + SP T L CE S + L ++ +G L R ++GA S + Sbjct: 3765 AIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKL---DFRLQQGAYRLLPSNA 3820 Query: 343 FSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399 LT ++S + C N +G + + ++V VP P + + + A V L Sbjct: 3821 LLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVHVP---PTIADDQTDFTVTMMAPVVL 3876 Query: 400 HCEAQRGSLPILYQFHHEGAALERRSA----NSAGGVAISFSLTAEHSGNYYCTADNGFG 455 C + P + + GA L R + + +G + I +L H+G Y C+A N G Sbjct: 3877 TCHSTGIPAPTV-SWSKAGAQLGARGSGYRVSPSGALEIGQALPI-HAGRYTCSARNSAG 3934 Query: 456 PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515 PV P+ ++ A A V L CE G P+ + E + + Sbjct: 3935 VAHKHVFLTVQASPVVKPLPSVVRAVA----EEEVLLPCEAS-GIPRPTITWQKEGLNVA 3989 Query: 516 SSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572 + + V G++ + + E +GNY C A N G + L V VP P++ + Sbjct: 3990 TGVSTQVLPGGQLRIAHASPED-AGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGL 4044 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-SGGEASFNL--------- 622 P G L C+A RGSP ++T P SG E F + Sbjct: 4045 PDLSTTEGSHAFLPCKA-RGSP-------EPNITWDKDGQPVSGAEGKFTIQPSGELLVK 4096 Query: 623 SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 +L + +G Y+C A N V + + L+++V P+ T +GD L L C A Sbjct: 4097 NLEGQDAGTYTCTAENA-VGRARRRVHLTILV---LPVFTTLPGDRSLRLGDRLWLRCAA 4152 Query: 683 LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL-EAQRSEMV 741 +P + W ++ +S GG +++ E SG Y C A+N + Q V Sbjct: 4153 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212 Query: 742 TLKVAVPVSRPVLTLRA-PGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800 +K A PVL A VG ++L C +RG P+ + + + L R S Sbjct: 4213 HVKEA-----PVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDIHWIKDGLPL--RGSHL 4264 Query: 801 GGASLNLSLT-----AEHSGNYSCEADNGLGAQRSETV 833 N SLT + +G Y C A+N +G + + Sbjct: 4265 RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVI 4302 Score = 106 bits (264), Expect = 1e-22 Identities = 207/857 (24%), Positives = 326/857 (38%), Gaps = 83/857 (9%) Query: 19 RTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY----LGKEILRETPDNI 74 + P I L T V+L C +P+ T WY LG+E+ + Sbjct: 2934 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT-WYKDSQALSLGEEVFLLPGTHT 2992 Query: 75 LEV-----QESGEYRCQAQGSP--------LSSPVHLDFSSASLILQAPLSVFEGDSVVL 121 L++ +SG Y C+A + LS V F A Q + V GD VL Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 3052 Query: 122 RCRAKAEVTLNNTIYKNDNVLAFLNKRTD-------FHIPHACLKDNGAYRCTGYKESCC 174 C A T YK+ L L +RT I A + D G Y C + Sbjct: 3053 SCETDALPEPTVTWYKDGQPLV-LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 3111 Query: 175 PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 V + T+ +QV F P + + ++G+P+ LTC+ + L+ R + Sbjct: 3112 AVRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA 3169 Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294 + S Q++ + +G Y C A + +++ + ++ + A + Sbjct: 3170 VHGVVSRGGRLQLSRLQPAQAGTYTCVAE----NTQAEARKDFVVAVLVAPRIRSSGVAR 3225 Query: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-----RHKSVRCERGASISFSLTTEN 349 + EG +V L CE + + +G PL H + G+ + L + Sbjct: 3226 EHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 3284 Query: 350 SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLP 409 +G Y C A N G + ++ +++V VP + S + G VT+ C RGS P Sbjct: 3285 AGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPP 3342 Query: 410 ILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466 I + +G L +R + +G + +G + C A + G + +L V Sbjct: 3343 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQV 3401 Query: 467 TV-PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRV 525 V PV PV + + + G+ V L CE RG P L + + PL S S + Sbjct: 3402 QVPPVLEPVEFQN--DVVVVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLEQGPSL 3458 Query: 526 SFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV-GDLLE 584 ++ G SG Y C A + G R +TV I P ++ G +E Sbjct: 3459 QLE-AVGAGDSGTYSCVAVSEAGEARRH---FQLTVMEPPHIEDSGQPTELSLTPGAPME 3514 Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644 L C+A P + W H+D G + + L +G Y+C L Sbjct: 3515 LLCDAQGTPQPNITW--HKD---GQALTRLENNSRATRVLRVRDAGLYTC-----LAESP 3564 Query: 645 SDTISLSVIVPVSRP--ILTFRAPR-AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701 + I S V V P I+ R PR + L L C +P + W H D + Sbjct: 3565 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW--HRDGIVL 3622 Query: 702 KISA----PSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757 + A P G +L+T SG YSC A N A S V +V + + P + Sbjct: 3623 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARN---AAGSTSVAFRVEIH-TVPTIRSG 3678 Query: 758 APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLTAE 812 P + +V L C+A G P L + + V L RS P G + + A+ Sbjct: 3679 PPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ-PVLAQ 3736 Query: 813 HSGNYSCEADNGLGAQR 829 +G+Y C A N G+ R Sbjct: 3737 DAGHYLCLASNSAGSDR 3753 Score = 94.0 bits (232), Expect = 6e-19 Identities = 228/981 (23%), Positives = 344/981 (35%), Gaps = 179/981 (18%) Query: 16 QFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKEILR--ETP 71 Q T P + P TV GE L+C+ +P W R L R + Sbjct: 510 QIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG-EAPYNLTWVRDWRVLPASTGRVAQLA 568 Query: 72 DNILEVQ-----ESGEYRC---QAQGSPLSSPVHLDFSSASLILQAPLSVF-EGDSVVLR 122 D LE+ + G Y+C A G +S L + + + F +G V + Sbjct: 569 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 628 Query: 123 CRAKAEVTLNNTIYKNDNVLA-----FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVS 177 C A T + + + L ++ + I +D G Y C E Sbjct: 629 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE--VGTD 686 Query: 178 SNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRD--DQTL 235 TV + +P + + A + G L CE P R ++R + L Sbjct: 687 QETVTLYYTDPPSVSAVNAVVLVAV-GEEAVLVCEAS-----GVPPPRVIWYRGGLEMIL 740 Query: 236 GLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASH-PVLTLSPE 294 S S +I A +D+G Y C+A +++ + ++Q+ H P LT P Sbjct: 741 APEGSSSGKLRIPAAQERDAGTYTCRA-------VNELGDASAEIQLAVGHAPQLTELPR 793 Query: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR--------HKSVRCERGASISFSLT 346 G L C T+ +G PL +S + + G S+ Sbjct: 794 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853 Query: 347 TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG 406 E+ Y C A N G ++A + + P + S+P + EG V+L C G Sbjct: 854 PEDQAPYVCEARNVFGKVQAEA--RLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAG 911 Query: 407 SLPILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVS 463 + +G L R S + G + + +L EH+G Y C A N G Q + V Sbjct: 912 RPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQ-EHAGRYSCVATNTAGSQH-RDVE 969 Query: 464 LSVTVPVS-HPVLTLSSAEALTFEGATVTL--------------------------HCEV 496 L V VP HP T +T EG +L H V Sbjct: 970 LVVQVPPRIHPTAT----HHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV 1025 Query: 497 QRGSPQILYQFYHEDMPLWSSSTP------------SVGRVSFSFSLTE----------- 533 + ++ Q +D + + SV R++ S + E Sbjct: 1026 SKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLR 1085 Query: 534 ------GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRA-QAVVGDLLELH 586 G SG+Y CTA N G V P +P PR + +VG+ L+L+ Sbjct: 1086 LAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQP-----GPRVLKVLVGEALDLN 1140 Query: 587 CEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSD 646 C A P L W +D + P G + ++ +G Y CEA+N + Sbjct: 1141 CVAEGNPEPQLSW--SKDGVVLQGRGPQG--SVHFAAIRTSDAGRYRCEASNS-AGVDAW 1195 Query: 647 TISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAP 706 + L V+ P + + V G+ L C A P + W G S P Sbjct: 1196 EVELRVLEPPHWG-ADETSGLLERVAGENASLPCPARGTPKPQVTW------RKGPSSEP 1248 Query: 707 SGG---------GASFNLSLTTEHSGIYSCEADN--GLEAQRSEMVTLKVAVPVSRPVLT 755 G G+ F S++ SG Y C+A N G ++R+++V V VP S Sbjct: 1249 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLV---VYVPPS----- 1300 Query: 756 LRAPGTHAAV----GDLLELHCEA---------------LRGSPL--ILYRFFHEDVTLG 794 +R G A V G L L C+A L G PL Y + +G Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360 Query: 795 NRSSPSGGASLNLSLTAE-HSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVA 853 G SL+ E SG YSC A+N G + + L +T P + A Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT--------PPSVLGA 1412 Query: 854 GGLLSIAGLAAGALLLYCWLS 874 G + GLA + L CW S Sbjct: 1413 GAAQEVLGLAGADVELQCWTS 1433 Score = 92.8 bits (229), Expect = 1e-18 Identities = 213/899 (23%), Positives = 324/899 (36%), Gaps = 141/899 (15%) Query: 34 VFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRE-----TPDNIL------EVQESGE 82 V G+ L C P+ T W+ G+ + R +PD +L + +G Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLT-WFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGH 2513 Query: 83 YRCQAQGSPLSSPVHLDFSSASLILQAP-------------LSVFEGDSVVLRCRAKAEV 129 Y C A + H S +L AP ++V + + L C A A Sbjct: 2514 YSCIAANAVGEKTKHFQLS----VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 2569 Query: 130 TLNNTIYKN------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + N T K+ + L I +A +D G Y C E V + V++ Sbjct: 2570 SPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 2629 Query: 184 QVQEPFTRP----VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ------ 233 + ++ + + + +TL CE+ + P R+++D Q Sbjct: 2630 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW-----AVPPPTIRWYKDGQPVTPSS 2684 Query: 234 ---TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQV-QIP 283 LG G L QI DSG Y C A + ++V+ P + +V Sbjct: 2685 RLQVLGEGRLL----QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 2740 Query: 284 ASHPVLTLSPEKALNF-------EGTKVTLHCETQEDSLRTLYRFYHEGVPLR---HKSV 333 A+ +L+ E E L+C+T L +Y E PL SV Sbjct: 2741 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSV 2799 Query: 334 RCERGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392 + G + L EN+G Y C A N +G L +T PV L E+L+ Sbjct: 2800 -LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-----LGDTEELVE 2853 Query: 393 E-----GAKVTLHCEAQRGSLPILYQFHH--EGAALERRSANSAGGVAISFSLTAEHSGN 445 E + V+L C A +P + + + R G V + + + Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 2913 Query: 446 YYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSPQIL 504 Y C A+N G K +L V VP L L A+ ++V+L C+V +P++ Sbjct: 2914 YMCVAENQAG-SAEKLFTLRVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 2970 Query: 505 Y-------QFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSL 557 + E L + T +GR S SG Y C A N G + ++V L Sbjct: 2971 WYKDSQALSLGEEVFLLPGTHTLQLGRARLS------DSGMYTCEALNAAG-RDQKLVQL 3023 Query: 558 FVTVPVSRPILTLRVPRA--QAV---VGDLLELHCEAPRGSPPILYWFYHED--VTLGSS 610 V VP + + PR AV VGD L CE P + W+ V + Sbjct: 3024 SVLVPPA----FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 3079 Query: 611 SAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQA 670 A GG+ G YSC+ +N + + T +L+V VP TF P+ + Sbjct: 3080 QALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTVQVPP-----TFENPKTET 3133 Query: 671 ---VVGDLLELHCEALRGSSPILYWFYHE-DVTLGKISAPSGGGASFNLS-LTTEHSGIY 725 V G L L C+ +P + W V + G LS L +G Y Sbjct: 3134 VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTY 3193 Query: 726 SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785 +C A+N R + V + P R R H G + L CEA G P Sbjct: 3194 TCVAENTQAEARKDFVVAVLVAPRIRSSGVARE--HHVLEGQEVRLDCEA-DGQPPPDVA 3250 Query: 786 FFHEDVTLGNRSSP------SGGASLNLSLTAEHSGNYSCEADNGLGAQ-RSETVTLYI 837 + + LG P GG+ + L A +G Y+C A N G R TV + + Sbjct: 3251 WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 3309 Score = 90.1 bits (222), Expect = 9e-18 Identities = 203/898 (22%), Positives = 328/898 (36%), Gaps = 136/898 (15%) Query: 40 VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNIL------------EVQESGEYRCQA 87 +TL C+ P +W+ G+E + D L + Q+SG Y C A Sbjct: 2370 LTLLCEAMGI-PPPAIRWFR---GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 2425 Query: 88 QGSPLSSPVHLDFSSASLI--------LQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKND 139 + +FS L+ L+ + V +G + L C T +K+ Sbjct: 2426 SNE--AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 2483 Query: 140 NVLAFLNKRTDFH----------IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPF 189 LA R D H + A L G Y C V T Q+ Sbjct: 2484 RPLA----RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLL 2535 Query: 190 TRPVLRA---SSFQPIS---GNPVTLTCET------QLSLERSDVPLRFRFFRDDQTLGL 237 +L S+ + ++ NP++L CE ++ + P F R+ Q L Sbjct: 2536 APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPG 2593 Query: 238 GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPAS----HPVLTLS 292 L QI +D+G Y C + + ++ +++ ++V IP S P+ + Sbjct: 2594 THGL----QILNAQKEDAGQYTCVVT----NELGEAVKNYHVEVLIPPSISKDDPLGEVG 2645 Query: 293 PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLT---TEN 349 ++ + +TL CE+ T+ R+Y +G P+ S G + + Sbjct: 2646 VKEVKTKVNSTLTLECESWAVPPPTI-RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSD 2704 Query: 350 SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------------IFE 393 SG Y C A N G L P+ V + S+ ++ I E Sbjct: 2705 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 2764 Query: 394 GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAEHSGNYYCTAD 451 L+C+ P L + + +A + S G V + AE++G Y C A Sbjct: 2765 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 2824 Query: 452 NGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFE-----GATVTLHCEVQRGSPQILYQ 506 N G L +T PV L E L E +TV+L C G+P Sbjct: 2825 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTIS 2878 Query: 507 FYHEDMPLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPV 563 + +P S V G+V + + +Y C A+N G ++ +L V VP Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG-SAEKLFTLRVQVPP 2937 Query: 564 SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHED-VTLGSSSAPSGGEASFNL 622 I L + + A++ + L C+ P + W+ ++LG G + L Sbjct: 2938 R--IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 2995 Query: 623 SLTA-EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR-APRA--QAV---VGDL 675 SG Y+CEA N + + LSV+VP + FR APR AV VGD Sbjct: 2996 GRARLSDSGMYTCEALNA-AGRDQKLVQLSVLVPPA-----FRQAPRGPQDAVLVRVGDK 3049 Query: 676 LELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLS-LTTEHSGIYSCEADNGL 733 L CE P + W+ + + L + + GG + G+YSC+ N Sbjct: 3050 AVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVA 3109 Query: 734 -EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 EA R+ +T++V P + G L L C+ + G P + + + Sbjct: 3110 GEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCD-VSGVPAPTVTWLKDRMP 3164 Query: 793 LGNRSSP---SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSG 846 + + + S G L LS L +G Y+C A+N R + V + SG Sbjct: 3165 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG 3222 Score = 84.0 bits (206), Expect = 6e-16 Identities = 127/498 (25%), Positives = 185/498 (37%), Gaps = 39/498 (7%) Query: 351 GNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPI 410 G Y CTA + G +KA + VT P P + +P + G L C G P Sbjct: 492 GTYECTAVSRAGTGRAKA-QIVVTDP---PPQLVPAPNVTVSPGETAVLSCRVL-GEAPY 546 Query: 411 LYQFHHEGAALERRSANSAGGVAISFSLTA---EHSGNYYCTADNGFGPQRSKAVSLSVT 467 + + L + A +S ++ G Y C A N G R+ SV Sbjct: 547 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-----SVW 601 Query: 468 VPVSH-PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVS 526 + V P +++ ++ +G V + C G P + E L S V Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSAS-GYPTPHISWSRESQALQEDSRIHVDAQG 660 Query: 527 FSF--SLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLE 584 + +GNY C A N G + E V+L+ T P S + V A VG+ Sbjct: 661 TLIIQGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYTDPPSVSAVNAVVLVA---VGEEAV 716 Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644 L CEA PP + W+ + + S G+ + + +G Y+C A N L Sbjct: 717 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD-AGTYTCRAVNEL-GDA 774 Query: 645 SDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG-KI 703 S I L+V P LT +G L C A P + W + LG ++ Sbjct: 775 SAEIQLAV---GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 831 Query: 704 SAPSGG-------GASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTL 756 A G G F S+ E Y CEA N ++E + + P + Sbjct: 832 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAE--ARLIVTGHAPPQIAS 889 Query: 757 RAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTL--GNRSSPSGGASLNLSLTA-EH 813 AP G + L C L G PL + + L G+R S SL+L EH Sbjct: 890 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEH 949 Query: 814 SGNYSCEADNGLGAQRSE 831 +G YSC A N G+Q + Sbjct: 950 AGRYSCVATNTAGSQHRD 967 Score = 80.5 bits (197), Expect = 7e-15 Identities = 220/899 (24%), Positives = 319/899 (35%), Gaps = 157/899 (17%) Query: 37 GERVTLTCKGFRFYSPQKTKW--------YHRYLGKEILRETPDNILEVQ--ESGEYRCQ 86 GE +L C PQ T W H G +L E + V +SG+Y CQ Sbjct: 1221 GENASLPCPARGTPKPQVT-WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279 Query: 87 AQGSPLSSPVHLDFSSASLILQAPLSVFE-----------GDSVVLRCRAKAEVTLNNTI 135 A ++ V A L++ P S+ E G S+ L C A + + Sbjct: 1280 A-----TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANG-FPVPEIV 1333 Query: 136 YKNDNVLA----------------------FLNKRTDFHIPHACLKDNGAYRCTGYKESC 173 + D L L++ H P D+G Y C E+ Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA--ENQ 1391 Query: 174 CPVSSNTVKIQVQEPFTRPVLRASSFQPI---SGNPVTLTCETQLSLERSDVPL-RFRFF 229 + + V P + VL A + Q + +G V L C T S VP + + Sbjct: 1392 AGTAQRDFHLLVLTPPS--VLGAGAAQEVLGLAGADVELQCWT------SGVPTPQVEWT 1443 Query: 230 RDDQTLGLGWSLSPNFQ---------ITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQV 280 +D Q + G P+ Q IT D G Y C A +S R + Q+ Sbjct: 1444 KDRQPVLPG---GPHLQVQEDGQVLRITGSHVGDEGRYQCVA----FSPAGQQARDF-QL 1495 Query: 281 QIPASHPVLTLSPE--KALNFEGTKVTLHCETQEDSLRTLYRFYHEG--VPLRHKSVRCE 336 ++ A P + S E + E V L CE + + ++ +G +P K V Sbjct: 1496 RVHAP-PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI-TWFKDGALLPTSTKVVYTR 1553 Query: 337 RGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFE-- 393 G + + ++G Y C A N +GA KA L V VP P + + + + Sbjct: 1554 GGRQLQLGRAQSSDAGVYTCKASNAVGAA-EKATRLDVYVP---PTIEGAGGRPYVVKAV 1609 Query: 394 -GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAE-HSGNYYCT 449 G V L C A+ P L +HHEG A S G + E SG Y C Sbjct: 1610 AGRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV 1668 Query: 450 ADNGFGPQRSKAVSLSVTVPVSHPVLTLSS-AEALTFEGATVTLHCEVQRGSPQILYQFY 508 A + P + SV V V +L + T G + L C+ GSP Q+ Sbjct: 1669 ASS---PAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS-GSPVPTIQWL 1724 Query: 509 HEDMP---LWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSR 565 P L S G + HSG + C A N G +EV V+V Sbjct: 1725 QNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVE---VSVHGEW 1781 Query: 566 PILTLRVPRAQAVVGDLLELHCEAPRGSPPILY--WFYHEDVTLGSS--------SAPSG 615 L VP Q G E H P P ++ W H L P+G Sbjct: 1782 APGVLEVPIGQYHWGX--EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG 1839 Query: 616 GEASFNL-------SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRA 668 +++L + G Y+C A N L + ++L V+VP + P Sbjct: 1840 IPVAYSLPPPLQIEKVDLRDEGIYTCAATN-LAGESKREVALKVLVPPNIE----PGPVN 1894 Query: 669 QAVVGDL-LELHCEALRGSSPILYWFY-HEDVTLGKISAPSGGGASFNLSLTT-EHSGIY 725 +AV+ + + L C A P + WF H+ V+ S G + +G Y Sbjct: 1895 KAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSY 1954 Query: 726 SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG-SPLILY 784 C A N + L+V VP R L PG V + L C A SP +++ Sbjct: 1955 RCVASN-VAGSTELRYGLRVNVP-PRITLPPSLPGP-VLVNTPVRLTCNATGAPSPTLMW 2011 Query: 785 RFFHEDVTLGNRSSPSGGASLNL----------SLTAEHSGNYSCEADNGLGAQRSETV 833 + GN SP+G L + S A SG YSC A + +G R + V Sbjct: 2012 ------LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 2064 Score = 80.1 bits (196), Expect = 9e-15 Identities = 150/652 (23%), Positives = 241/652 (36%), Gaps = 62/652 (9%) Query: 206 PVTLTCETQLSLERSDVPLRFRFFRDDQTLG----LGWSLSPNFQITAMWSKDSGFYWCK 261 P+ ++C +L P R + R + LG S + +++I + G Y C Sbjct: 443 PLLVSCSVHSAL-----PFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECT 497 Query: 262 AATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRF 321 A + + + R+ Q+ + P L +P ++ G L C ++ L + Sbjct: 498 AVSR-----AGTGRAKAQIVVTDPPPQLVPAPNVTVS-PGETAVLSCRVLGEAPYNL-TW 550 Query: 322 YHEGVPLRHKSVRCERGASISFSLT---TENSGNYYCTADNGLGAKPSKAVSLSVTVPVS 378 + L + R + A +S ++ + G Y C A N G + SV + V Sbjct: 551 VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-----SVWLLVR 605 Query: 379 H-PVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSAN--SAGGVAIS 435 P +++ + +G +V + C A P + + E AL+ S A G I Sbjct: 606 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI-SWSRESQALQEDSRIHVDAQGTLII 664 Query: 436 FSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCE 495 + E +GNY C A N G + + V+L T P P ++ +A L G L CE Sbjct: 665 QGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYTDP---PSVSAVNAVVLVAVGEEAVLVCE 720 Query: 496 VQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVV 555 P + + + + S G++ + E +G Y C A N G +E+ Sbjct: 721 ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP-AAQERDAGTYTCRAVNELGDASAEI- 778 Query: 556 SLFVTVPVSRPILTLRVPRAQAV-VGDLLELHCEAPRGSPPILYWFYHEDVTLG------ 608 + V +PR V +G L C A PP + W + LG Sbjct: 779 ----QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAG 834 Query: 609 ---SSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRA 665 S P G F S+ E Y CEA N ++ + ++ + P + A Sbjct: 835 RGSRSRQPDSGVLFFE-SVAPEDQAPYVCEARNVFGKVQAE--ARLIVTGHAPPQIASSA 891 Query: 666 PRAQAVVGDLLELHCEALRGSS-PILYWFYH-EDVTLGKISAPSGGGASFNLSLTTEHSG 723 P + + G + L C L G P +W + G + G+ EH+G Sbjct: 892 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 951 Query: 724 IYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLIL 783 YSC A N +Q + V L V VP P + A G L C A G P Sbjct: 952 RYSCVATNTAGSQHRD-VELVVQVP---PRIHPTATHHITNEGVPASLPCVA-SGVPAPT 1006 Query: 784 YRFFHEDVTLGNR----SSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSE 831 + E L +R + G L +A+ +G Y C A N +G E Sbjct: 1007 ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE 1058 Score = 79.3 bits (194), Expect = 2e-14 Identities = 102/392 (26%), Positives = 160/392 (40%), Gaps = 27/392 (6%) Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 E++GNY C A N G+ K L V VP PV+ P+ EG+ L C+A RGS Sbjct: 4010 EDAGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGLPDLSTTEGSHAFLPCKA-RGS 4064 Query: 408 LPILYQFHHEG---AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464 + +G + E + G + +L + +G Y CTA+N G R + V L Sbjct: 4065 PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR-VHL 4123 Query: 465 SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGR 524 ++ V PV T + G + L C RGSP + D P+ + G Sbjct: 4124 TILVL---PVFTTLPGDRSLRLGDRLWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDGG 4179 Query: 525 VSFS-FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583 + +++ SG Y C A+N G R++ VS FV V + + VG + Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVG--RTQAVS-FVHVKEAPVLQGEAFSYLVEPVGGSI 4236 Query: 584 ELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGL- 640 +L C RG P P ++W GS S + T + +G Y C A N + Sbjct: 4237 QLDCVV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMG 4295 Query: 641 VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFY-HEDVT 699 VA+ + ++V S P+ GD + L C+A +P + W + + Sbjct: 4296 VAK-----KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR 4350 Query: 700 LGKISAPSGGGASFNLSLTTEHSGIYSCEADN 731 + G+ + ++ T +G Y C A N Sbjct: 4351 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 4382 Score = 76.6 bits (187), Expect = 1e-13 Identities = 134/520 (25%), Positives = 188/520 (36%), Gaps = 84/520 (16%) Query: 349 NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL 408 + G Y C A N L + + V+L V VP P + + E A VTL C A Sbjct: 1859 DEGIYTCAATN-LAGESKREVALKVLVP---PNIEPGPVNKAVLENASVTLECLASGVPP 1914 Query: 409 PILYQF--HHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466 P + F H ++ + + G V +G+Y C A N G + L V Sbjct: 1915 PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRV 1973 Query: 467 TVPVSHPVLTLS-SAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV--- 522 VP P +TL S V L C G+P + + P+ + TP + Sbjct: 1974 NVP---PRITLPPSLPGPVLVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVF 2029 Query: 523 --GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVG 580 GRV S SG Y C A + G R +VV L V +P P + V Sbjct: 2030 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMP---PSILGEELNVSVVAN 2085 Query: 581 DLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHS----------- 629 + + L C++ PP+L W+ G P G + L+A+ + Sbjct: 2086 ESVALECQSHAMPPPVLSWWKD-----GRPLEPRPG-----VHLSADKALLQVDRADVWD 2135 Query: 630 -GNYSCEANNGLVAQHSDT-ISLSVIVPVSRPILTFRAPRAQAV-VGDLLELHCEALRGS 686 G+Y+CEA N A HS+ +L+V V P+ R V G L CE Sbjct: 2136 AGHYTCEALNQ--AGHSEKHYNLNVWVA---PVFPLRESHTLTVREGHPTSLSCECRGVP 2190 Query: 687 SPILYW------FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740 P + W E L +SA G + G Y+CE N + S+ Sbjct: 2191 FPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSN-VVGNSSQD 2247 Query: 741 VTLKVAVPVSRPVLTLRAPGTHAAV--GDLLELHCEALRGSPLILYRFFHEDVTLGNRSS 798 + L+V VP + R P T +V + L C A P R Sbjct: 2248 LQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPP---------PTVTWERDG 2296 Query: 799 PSGGASLNLSLT------------AEHSGNYSCEADNGLG 826 GA L L L A H+G YSC A+N G Sbjct: 2297 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 2336 Score = 75.9 bits (185), Expect = 2e-13 Identities = 185/837 (22%), Positives = 291/837 (34%), Gaps = 141/837 (16%) Query: 79 ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEV 129 +SG Y C A S V D L + P +SV +SV L C++ A Sbjct: 2044 DSGRYSCVAV-----SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMP 2098 Query: 130 TLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + +K+ L + + A + D G Y C ++ + + Sbjct: 2099 PPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158 Query: 184 QVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTL-GLGWSL 241 V F P+ + + G+P +L+CE + VP + + +D Q L G G L Sbjct: 2159 WVAPVF--PLRESHTLTVREGHPTSLSCECR------GVPFPKISWRKDGQPLPGEGAGL 2210 Query: 242 SPNFQITAMWS------KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEK 295 + + G Y C+ + + V + S ++V +P P + Sbjct: 2211 QHVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQ 2267 Query: 296 ALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE------- 348 + TL C T+ + +G P+ GA + L + Sbjct: 2268 VSVVQDGVATLECNATGKPPPTV-TWERDGQPV---------GAELGLQLQNQGQSLHVE 2317 Query: 349 -----NSGNYYCTADNGLGAKPSKAVSLSVTVPVS-----HPVLNLSSPEDLIFEGAKVT 398 ++G Y C A+N L + + LSV VP P+ N+++ + +T Sbjct: 2318 RAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPELIGDLDPLTNITAALH-----SPLT 2371 Query: 399 LHCEAQRGSLPILYQFHHEGAALERRSANS-AGGVAISFSLTAEH-SGNYYCTADNGFGP 456 L CEA P + F E AGG + + T E SG Y C A N G Sbjct: 2372 LLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE 2431 Query: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516 R + S+ V VP S L + +G T L C V G PQ ++ + PL Sbjct: 2432 AR-RNFSVEVLVPPSIENEDLEEVIKV-LDGQTAHLMCNVT-GHPQPKLTWFKDGRPLAR 2488 Query: 517 SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572 + + + + +G+Y C A N G + +S+ + + Sbjct: 2489 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 2548 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTA------ 626 V + + L CEA P + W AP EAS N+ L Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWM--------KDGAPF--EASRNIQLLPGTHGLQ 2598 Query: 627 ------EHSGNYSCEANNGLVAQHSDTISLSVIVPVS----RPILTFRAPRAQAVVGDLL 676 E +G Y+C N L + + V++P S P+ + V L Sbjct: 2599 ILNAQKEDAGQYTCVVTNEL-GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTL 2657 Query: 677 ELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLSLT-TEHSGIYSCEADNGLE 734 L CE+ P + W+ + VT G G + T SG Y C A N Sbjct: 2658 TLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 2717 Query: 735 AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG----------SPLILY 784 + L P+ + V G +A ++L EA G +P LY Sbjct: 2718 EDDQDFNVLIQVPPMFQKV------GDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 2771 Query: 785 -----------RFFHEDVTLGNRSSPS---GGASLNLSLT-AEHSGNYSCEADNGLG 826 ++ ED L S GG L + L AE++G YSC+A N +G Sbjct: 2772 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 2828 Score = 70.9 bits (172), Expect = 6e-12 Identities = 159/613 (25%), Positives = 230/613 (37%), Gaps = 71/613 (11%) Query: 254 DSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQED 313 DSG Y C A+ S S R + VQ+P P + P G + L+C E Sbjct: 1093 DSGHYECTASNPAGSA---SHRYVLGVQVP---PQVQPGPRVLKVLVGEALDLNC-VAEG 1145 Query: 314 SLRTLYRFYHEGVPLRHKSVRCERGASISFS-LTTENSGNYYCTADNGLGAKPSKAVSLS 372 + + +GV L+ + + S+ F+ + T ++G Y C A N G + V L Sbjct: 1146 NPEPQLSWSKDGVVLQGRGPQ----GSVHFAAIRTSDAGRYRCEASNSAGV-DAWEVELR 1200 Query: 373 VTVPVSHPVLNLSSPEDLI--FEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAG 430 V P P L+ G +L C A RG+ P +G + E + Sbjct: 1201 VLEP---PHWGADETSGLLERVAGENASLPCPA-RGT-PKPQVTWRKGPSSE--PLHGQP 1253 Query: 431 GVAI-------SFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEAL 483 GVA+ S++ SG+Y C A N G S+ L V VP S A Sbjct: 1254 GVAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIRE-DGRKANVS 1311 Query: 484 TFEGATVTLHCEVQR-GSPQILY--QFYHEDMPL------WSSSTPSVG-------RVSF 527 G ++TL C+ P+I++ +PL W VG S Sbjct: 1312 GMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL 1371 Query: 528 SF-SLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDL---L 583 F + EG SG Y C A+N G + + L +T P L AQ V+G + Sbjct: 1372 HFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP-----SVLGAGAAQEVLGLAGADV 1426 Query: 584 ELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEH---SGNYSCEANNGL 640 EL C P + W L E L +T H G Y C A + Sbjct: 1427 ELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP- 1485 Query: 641 VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD-LLELHCEALRGSSPILYWFYHEDV- 698 Q + L V P + I AV+ D L++L CEA +P + WF + Sbjct: 1486 AGQQARDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 1543 Query: 699 -TLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757 T K+ GG + +G+Y+C+A N + A + L V VP + R Sbjct: 1544 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGR 1602 Query: 758 APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS---PSGGASLNLSLTAE-H 813 A G + L C A RG P + HE + + + + G+ L L E Sbjct: 1603 PYVVKAVAGRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEAS 1661 Query: 814 SGNYSCEADNGLG 826 SG YSC A + G Sbjct: 1662 SGLYSCVASSPAG 1674 Score = 69.7 bits (169), Expect = 1e-11 Identities = 113/488 (23%), Positives = 193/488 (39%), Gaps = 39/488 (7%) Query: 162 GAYRCTGYKESCCPVSSNTVKIQVQ-EPFTRPVLRASSFQPISGNPVTLTCETQLSLERS 220 G Y C+ + V+ V + VQ P +P+ S + ++ V L CE + R Sbjct: 3923 GRYTCSA--RNSAGVAHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEAS-GIPRP 3977 Query: 221 DVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWI 278 + + + G+ + P Q+ + +D+G Y C A S + ++ + Sbjct: 3978 TITWQKEGL--NVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMG---KTRL 4032 Query: 279 QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRC 335 VQ+P PV+ EG+ L C+ + S + +G P+ K Sbjct: 4033 VVQVP---PVIENGLPDLSTTEGSHAFLPCKAR-GSPEPNITWDKDGQPVSGAEGKFTIQ 4088 Query: 336 ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395 G + +L +++G Y CTA+N +G + + V L++ V PV + + G Sbjct: 4089 PSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVL---PVFTTLPGDRSLRLGD 4144 Query: 396 KVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG 455 ++ L C A+ P + ++ E S G +++ E SG Y C A+N G Sbjct: 4145 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 4204 Query: 456 PQRSKAVSLSVTVPVSHPVLTLSSAEALTFE--GATVTLHCEVQRGSPQILYQFYHEDMP 513 R++AVS V V + A + E G ++ L C V RG P + + +P Sbjct: 4205 --RTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLP 4258 Query: 514 LWSSSTP-SVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLR 571 L S + S + TE +G Y C A+N G + V + V S P+ + Sbjct: 4259 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV----ILVLQSAPVFQVE 4314 Query: 572 VPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL-SLTAEHSG 630 GD + L C+A P + W S + + S L ++ +G Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 4374 Query: 631 NYSCEANN 638 Y C A+N Sbjct: 4375 TYDCVAHN 4382 Score = 67.8 bits (164), Expect = 5e-11 Identities = 142/559 (25%), Positives = 211/559 (37%), Gaps = 71/559 (12%) Query: 349 NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL 408 +SG+Y CTA N G+ + V L V VP P + + G + L+C A+ Sbjct: 1093 DSGHYECTASNPAGSASHRYV-LGVQVP---PQVQPGPRVLKVLVGEALDLNCVAEGNPE 1148 Query: 409 PILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV 468 P L + +G L+ R + A ++ +G Y C A N G + V L V Sbjct: 1149 PQL-SWSKDGVVLQGRGPQGSVHFA---AIRTSDAGRYRCEASNSAGVD-AWEVELRVLE 1203 Query: 469 PVSHPVLTLSSAEALTFEGATVTLHCEVQRGS--PQILYQFYHEDMPLWSSSTPSVGRVS 526 P H +S G +L C RG+ PQ+ ++ PL P V + Sbjct: 1204 P-PHWGADETSGLLERVAGENASLPCPA-RGTPKPQVTWRKGPSSEPL--HGQPGVAVLE 1259 Query: 527 ----FSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDL 582 F S++ SG+Y C A N G S L V VP S R + G Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIR-EDGRKANVSGMAGQS 1317 Query: 583 LELHCEAPRGSPPILYWF--------------YHEDV---TLGSSSAPSGGEASFNLSLT 625 L L C+A P + W Y D+ +G G++ + Sbjct: 1318 LTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 1377 Query: 626 AEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDL---LELHCEA 682 SG YSC A N D L V+ P S A AQ V+G +EL C Sbjct: 1378 EGDSGLYSCRAENQAGTAQRD-FHLLVLTPPS----VLGAGAAQEVLGLAGADVELQCWT 1432 Query: 683 LRGSSPILYWFYHEDVTLGKISAPSGGGASFN-----LSLTTEH---SGIYSCEADNGLE 734 +P + W L P G L +T H G Y C A + Sbjct: 1433 SGVPTPQVEWTKDRQPVL-----PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP-A 1486 Query: 735 AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGD-LLELHCEALRGSPLILYRFFHEDVTL 793 Q++ L+V P + + G A + D L++L CEA RG P +F + L Sbjct: 1487 GQQARDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEA-RGVPTPNITWFKDGALL 1543 Query: 794 GNRSS---PSGGASLNLS-LTAEHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSG-P 847 + GG L L + +G Y+C+A N +G A+++ + +Y+ G P Sbjct: 1544 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRP 1603 Query: 848 FAT-GVAGGLLSIAGLAAG 865 + VAG +++ +A G Sbjct: 1604 YVVKAVAGRPVALECVARG 1622 Score = 47.0 bits (110), Expect = 9e-05 Identities = 60/235 (25%), Positives = 89/235 (37%), Gaps = 25/235 (10%) Query: 614 SGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVG 673 SG + L + G Y C A V++ + + IV P AP G Sbjct: 476 SGNSSWEILRASKAEEGTYECTA----VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPG 531 Query: 674 DLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGI-------YS 726 + L C L + L W V ++ S G + L+ E SGI Y Sbjct: 532 ETAVLSCRVLGEAPYNLTW-----VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 586 Query: 727 CEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRF 786 C A N R+ + L P +++ H + G +++ C A G P + Sbjct: 587 CVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISW 641 Query: 787 FHEDVTLGNRSS---PSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYIT 838 E L S + G + + E +GNYSC+A N +G + ETVTLY T Sbjct: 642 SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYT 695 Score = 40.8 bits (94), Expect = 0.006 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 40/314 (12%) Query: 75 LEVQESGEYRCQAQGSP--LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVT 130 LE Q++G Y C A+ + VHL + P S+ GD + LRC A+ T Sbjct: 4098 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 4157 Query: 131 LNNTIYKNDNVLAFLNKRTD----FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQ 186 ND + D +D+G Y C + E+ + + V+ Sbjct: 4158 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC--WAENRVGRTQAVSFVHVK 4215 Query: 187 EPFTRPVLRASSF----QPISGNPVTLTCETQ------LSLERSDVPLRFRFFRDDQTLG 236 E PVL+ +F +P+ G+ + L C + + + +PLR R G Sbjct: 4216 EA---PVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG 4271 Query: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296 + I D+G Y C A + + + S PV + P+ Sbjct: 4272 -------SLTIHRTERDDAGRYQCLAEN------EMGVAKKVVILVLQSAPVFQVEPQDM 4318 Query: 297 LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRCERGASISF-SLTTENSGNYY 354 G V L C+ + T+ + G PLR + +R S+ ++ T ++G Y Sbjct: 4319 TVRSGDDVALRCQATGEPTPTI-EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 4377 Query: 355 CTADNGLGAKPSKA 368 C A N LG+ ++A Sbjct: 4378 CVAHNLLGSATARA 4391 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 107 bits (266), Expect = 7e-23 Identities = 197/818 (24%), Positives = 319/818 (38%), Gaps = 121/818 (14%) Query: 74 ILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSV-----------FEGDSVVLR 122 +L V+++G Y C A+ SP S + +QAP ++ +VL Sbjct: 2266 VLRVRDAGLYTCLAE-----SPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE 2320 Query: 123 CRAKAEVTLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPV 176 C +AE T +++ VL F + + D+G Y CT + Sbjct: 2321 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA---- 2376 Query: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSL---ERSDVPLRFRFFRDDQ 233 S +V +V E T P +R SG P Q +L + VP +R D+ Sbjct: 2377 GSTSVAFRV-EIHTVPTIR-------SGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 2428 Query: 234 T----LGLGWSLSP--NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHP 287 + + P + +I + ++D+G Y C A+ S SD ++V P P Sbjct: 2429 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN---SAGSDRQGRDLRVLEP---P 2482 Query: 288 VLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGA-----SIS 342 + SP T L CE S + L ++ +G L R ++GA S + Sbjct: 2483 AIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKL---DFRLQQGAYRLLPSNA 2538 Query: 343 FSLTT---ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTL 399 LT ++S + C N +G + + ++V VP P + + + A V L Sbjct: 2539 LLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVHVP---PTIADDQTDFTVTMMAPVVL 2594 Query: 400 HCEAQRGSLPILYQFHHEGAALERRSA----NSAGGVAISFSLTAEHSGNYYCTADNGFG 455 C + P + + GA L R + + +G + I +L H+G Y C+A N G Sbjct: 2595 TCHSTGIPAPTV-SWSKAGAQLGARGSGYRVSPSGALEIGQALPI-HAGRYTCSARNSAG 2652 Query: 456 PQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLW 515 PV P+ ++ A A V L CE G P+ + E + + Sbjct: 2653 VAHKHVFLTVQASPVVKPLPSVVRAVA----EEEVLLPCEAS-GIPRPTITWQKEGLNVA 2707 Query: 516 SSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRV 572 + + V G++ + + E +GNY C A N G + L V VP P++ + Sbjct: 2708 TGVSTQVLPGGQLRIAHASPED-AGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGL 2762 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP-SGGEASFNL--------- 622 P G L C+A RGSP ++T P SG E F + Sbjct: 2763 PDLSTTEGSHAFLPCKA-RGSP-------EPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2814 Query: 623 SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 +L + +G Y+C A N V + + L+++V P+ T +GD L L C A Sbjct: 2815 NLEGQDAGTYTCTAENA-VGRARRRVHLTILV---LPVFTTLPGDRSLRLGDRLWLRCAA 2870 Query: 683 LRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGL-EAQRSEMV 741 +P + W ++ +S GG +++ E SG Y C A+N + Q V Sbjct: 2871 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930 Query: 742 TLKVAVPVSRPVLTLRA-PGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPS 800 +K A PVL A VG ++L C +RG P+ + + + L R S Sbjct: 2931 HVKEA-----PVLQGEAFSYLVEPVGGSIQLDC-VVRGDPVPDIHWIKDGLPL--RGSHL 2982 Query: 801 GGASLNLSLT-----AEHSGNYSCEADNGLGAQRSETV 833 N SLT + +G Y C A+N +G + + Sbjct: 2983 RHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVI 3020 Score = 106 bits (264), Expect = 1e-22 Identities = 207/857 (24%), Positives = 326/857 (38%), Gaps = 83/857 (9%) Query: 19 RTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY----LGKEILRETPDNI 74 + P I L T V+L C +P+ T WY LG+E+ + Sbjct: 1652 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT-WYKDSQALSLGEEVFLLPGTHT 1710 Query: 75 LEV-----QESGEYRCQAQGSP--------LSSPVHLDFSSASLILQAPLSVFEGDSVVL 121 L++ +SG Y C+A + LS V F A Q + V GD VL Sbjct: 1711 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1770 Query: 122 RCRAKAEVTLNNTIYKNDNVLAFLNKRTD-------FHIPHACLKDNGAYRCTGYKESCC 174 C A T YK+ L L +RT I A + D G Y C + Sbjct: 1771 SCETDALPEPTVTWYKDGQPLV-LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829 Query: 175 PVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234 V + T+ +QV F P + + ++G+P+ LTC+ + L+ R + Sbjct: 1830 AVRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA 1887 Query: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294 + S Q++ + +G Y C A + +++ + ++ + A + Sbjct: 1888 VHGVVSRGGRLQLSRLQPAQAGTYTCVAE----NTQAEARKDFVVAVLVAPRIRSSGVAR 1943 Query: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-----RHKSVRCERGASISFSLTTEN 349 + EG +V L CE + + +G PL H + G+ + L + Sbjct: 1944 EHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2002 Query: 350 SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLP 409 +G Y C A N G + ++ +++V VP + S + G VT+ C RGS P Sbjct: 2003 AGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPP 2060 Query: 410 ILYQFHHEGAAL---ERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466 I + +G L +R + +G + +G + C A + G + +L V Sbjct: 2061 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG-VADRNFTLQV 2119 Query: 467 TV-PVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRV 525 V PV PV + + + G+ V L CE RG P L + + PL S S + Sbjct: 2120 QVPPVLEPVEFQN--DVVVVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLEQGPSL 2176 Query: 526 SFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVV-GDLLE 584 ++ G SG Y C A + G R +TV I P ++ G +E Sbjct: 2177 QLE-AVGAGDSGTYSCVAVSEAGEARRH---FQLTVMEPPHIEDSGQPTELSLTPGAPME 2232 Query: 585 LHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQH 644 L C+A P + W H+D G + + L +G Y+C L Sbjct: 2233 LLCDAQGTPQPNITW--HKD---GQALTRLENNSRATRVLRVRDAGLYTC-----LAESP 2282 Query: 645 SDTISLSVIVPVSRP--ILTFRAPR-AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLG 701 + I S V V P I+ R PR + L L C +P + W H D + Sbjct: 2283 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW--HRDGIVL 2340 Query: 702 KISA----PSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLR 757 + A P G +L+T SG YSC A N A S V +V + + P + Sbjct: 2341 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARN---AAGSTSVAFRVEIH-TVPTIRSG 2396 Query: 758 APGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSS-----PSGGASLNLSLTAE 812 P + +V L C+A G P L + + V L RS P G + + A+ Sbjct: 2397 PPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ-PVLAQ 2454 Query: 813 HSGNYSCEADNGLGAQR 829 +G+Y C A N G+ R Sbjct: 2455 DAGHYLCLASNSAGSDR 2471 Score = 92.8 bits (229), Expect = 1e-18 Identities = 213/899 (23%), Positives = 324/899 (36%), Gaps = 141/899 (15%) Query: 34 VFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRE-----TPDNIL------EVQESGE 82 V G+ L C P+ T W+ G+ + R +PD +L + +G Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLT-WFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGH 1231 Query: 83 YRCQAQGSPLSSPVHLDFSSASLILQAP-------------LSVFEGDSVVLRCRAKAEV 129 Y C A + H S +L AP ++V + + L C A A Sbjct: 1232 YSCIAANAVGEKTKHFQLS----VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFP 1287 Query: 130 TLNNTIYKN------DNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + N T K+ + L I +A +D G Y C E V + V++ Sbjct: 1288 SPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1347 Query: 184 QVQEPFTRP----VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ------ 233 + ++ + + + +TL CE+ + P R+++D Q Sbjct: 1348 LIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW-----AVPPPTIRWYKDGQPVTPSS 1402 Query: 234 ---TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMP------YSVISDSPRSWIQV-QIP 283 LG G L QI DSG Y C A + ++V+ P + +V Sbjct: 1403 RLQVLGEGRLL----QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 1458 Query: 284 ASHPVLTLSPEKALNF-------EGTKVTLHCETQEDSLRTLYRFYHEGVPLR---HKSV 333 A+ +L+ E E L+C+T L +Y E PL SV Sbjct: 1459 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSV 1517 Query: 334 RCERGASISFSLT-TENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIF 392 + G + L EN+G Y C A N +G L +T PV L E+L+ Sbjct: 1518 -LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-----LGDTEELVE 1571 Query: 393 E-----GAKVTLHCEAQRGSLPILYQFHH--EGAALERRSANSAGGVAISFSLTAEHSGN 445 E + V+L C A +P + + + R G V + + + Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1631 Query: 446 YYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQ-RGSPQIL 504 Y C A+N G K +L V VP L L A+ ++V+L C+V +P++ Sbjct: 1632 YMCVAENQAG-SAEKLFTLRVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 1688 Query: 505 Y-------QFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSL 557 + E L + T +GR S SG Y C A N G + ++V L Sbjct: 1689 WYKDSQALSLGEEVFLLPGTHTLQLGRARLS------DSGMYTCEALNAAG-RDQKLVQL 1741 Query: 558 FVTVPVSRPILTLRVPRA--QAV---VGDLLELHCEAPRGSPPILYWFYHED--VTLGSS 610 V VP + + PR AV VGD L CE P + W+ V + Sbjct: 1742 SVLVPPA----FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 1797 Query: 611 SAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQA 670 A GG+ G YSC+ +N + + T +L+V VP TF P+ + Sbjct: 1798 QALRGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTVQVPP-----TFENPKTET 1851 Query: 671 ---VVGDLLELHCEALRGSSPILYWFYHE-DVTLGKISAPSGGGASFNLS-LTTEHSGIY 725 V G L L C+ +P + W V + G LS L +G Y Sbjct: 1852 VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTY 1911 Query: 726 SCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYR 785 +C A+N R + V + P R R H G + L CEA G P Sbjct: 1912 TCVAENTQAEARKDFVVAVLVAPRIRSSGVARE--HHVLEGQEVRLDCEA-DGQPPPDVA 1968 Query: 786 FFHEDVTLGNRSSP------SGGASLNLSLTAEHSGNYSCEADNGLGAQ-RSETVTLYI 837 + + LG P GG+ + L A +G Y+C A N G R TV + + Sbjct: 1969 WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 2027 Score = 91.3 bits (225), Expect = 4e-18 Identities = 203/898 (22%), Positives = 328/898 (36%), Gaps = 136/898 (15%) Query: 40 VTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNIL------------EVQESGEYRCQA 87 +TL C+ P +W+ G+E + D L + Q+SG Y C A Sbjct: 1088 LTLLCEAMGI-PPPAIRWFR---GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1143 Query: 88 QGSPLSSPVHLDFSSASLI--------LQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKND 139 + +FS L+ L+ + V +G + L C T +K+ Sbjct: 1144 SNE--AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 1201 Query: 140 NVLAFLNKRTDFH----------IPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPF 189 LA R D H + A L G Y C V T Q+ Sbjct: 1202 RPLA----RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLL 1253 Query: 190 TRPVLRA---SSFQPIS---GNPVTLTCET------QLSLERSDVPLRFRFFRDDQTLGL 237 +L S+ + ++ NP++L CE ++ + P F R+ Q L Sbjct: 1254 APTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPG 1311 Query: 238 GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPAS----HPVLTLS 292 L QI +D+G Y C + + ++ +++ ++V IP S P+ + Sbjct: 1312 THGL----QILNAQKEDAGQYTCVVT----NELGEAVKNYHVEVLIPPSISKDDPLAEVG 1363 Query: 293 PEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLT---TEN 349 ++ + +TL CE+ T+ R+Y +G P+ S G + + Sbjct: 1364 VKEVKTKVNSTLTLECESWAVPPPTI-RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSD 1422 Query: 350 SGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL----------------IFE 393 SG Y C A N G L P+ V + S+ ++ I E Sbjct: 1423 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 1482 Query: 394 GAKVTLHCEAQRGSLPILYQFHHEG--AALERRSANSAGGVAISFSLTAEHSGNYYCTAD 451 L+C+ P L + + +A + S G V + AE++G Y C A Sbjct: 1483 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1542 Query: 452 NGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFE-----GATVTLHCEVQRGSPQILYQ 506 N G L +T PV L E L E +TV+L C G+P Sbjct: 1543 NEVGEDWLHYELLVLTPPV-----ILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTIS 1596 Query: 507 FYHEDMPLWSSSTPSV---GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPV 563 + +P S V G+V + + +Y C A+N G ++ +L V VP Sbjct: 1597 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG-SAEKLFTLRVQVPP 1655 Query: 564 SRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHED-VTLGSSSAPSGGEASFNL 622 I L + + A++ + L C+ P + W+ ++LG G + L Sbjct: 1656 R--IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 1713 Query: 623 SLTA-EHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR-APRA--QAV---VGDL 675 SG Y+CEA N + + LSV+VP + FR APR AV VGD Sbjct: 1714 GRARLSDSGMYTCEALNA-AGRDQKLVQLSVLVPPA-----FRQAPRGPQDAVLVRVGDK 1767 Query: 676 LELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLS-LTTEHSGIYSCEADNGL 733 L CE P + W+ + + L + + GG + G+YSC+ N Sbjct: 1768 AVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVA 1827 Query: 734 -EAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVT 792 EA R+ +T++V P + G L L C+ + G P + + + Sbjct: 1828 GEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCD-VSGVPAPTVTWLKDRMP 1882 Query: 793 LGNRSSP---SGGASLNLS-LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSG 846 + + + S G L LS L +G Y+C A+N R + V + SG Sbjct: 1883 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG 1940 Score = 79.3 bits (194), Expect = 2e-14 Identities = 102/392 (26%), Positives = 160/392 (40%), Gaps = 27/392 (6%) Query: 348 ENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGS 407 E++GNY C A N G+ K L V VP PV+ P+ EG+ L C+A RGS Sbjct: 2728 EDAGNYLCIAKNSAGSAMGKT-RLVVQVP---PVIENGLPDLSTTEGSHAFLPCKA-RGS 2782 Query: 408 LPILYQFHHEG---AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL 464 + +G + E + G + +L + +G Y CTA+N G R + V L Sbjct: 2783 PEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR-VHL 2841 Query: 465 SVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGR 524 ++ V PV T + G + L C RGSP + D P+ + G Sbjct: 2842 TILVL---PVFTTLPGDRSLRLGDRLWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDGG 2897 Query: 525 VSFS-FSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583 + +++ SG Y C A+N G R++ VS FV V + + VG + Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVG--RTQAVS-FVHVKEAPVLQGEAFSYLVEPVGGSI 2954 Query: 584 ELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLSLTA-EHSGNYSCEANNGL- 640 +L C RG P P ++W GS S + T + +G Y C A N + Sbjct: 2955 QLDCVV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMG 3013 Query: 641 VAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFY-HEDVT 699 VA+ + ++V S P+ GD + L C+A +P + W + + Sbjct: 3014 VAK-----KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR 3068 Query: 700 LGKISAPSGGGASFNLSLTTEHSGIYSCEADN 731 + G+ + ++ T +G Y C A N Sbjct: 3069 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3100 Score = 76.6 bits (187), Expect = 1e-13 Identities = 134/520 (25%), Positives = 188/520 (36%), Gaps = 84/520 (16%) Query: 349 NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSL 408 + G Y C A N L + + V+L V VP P + + E A VTL C A Sbjct: 577 DEGIYTCAATN-LAGESKREVALKVLVP---PNIEPGPVNKAVLENASVTLECLASGVPP 632 Query: 409 PILYQF--HHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466 P + F H ++ + + G V +G+Y C A N G + L V Sbjct: 633 PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRV 691 Query: 467 TVPVSHPVLTLS-SAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSV--- 522 VP P +TL S V L C G+P + + P+ + TP + Sbjct: 692 NVP---PRITLPPSLPGPVLVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVF 747 Query: 523 --GRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVG 580 GRV S SG Y C A + G R +VV L V +P P + V Sbjct: 748 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMP---PSILGEELNVSVVAN 803 Query: 581 DLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHS----------- 629 + + L C++ PP+L W+ G P G + L+A+ + Sbjct: 804 ESVALECQSHAMPPPVLSWWKD-----GRPLEPRPG-----VHLSADKALLQVDRADVWD 853 Query: 630 -GNYSCEANNGLVAQHSDT-ISLSVIVPVSRPILTFRAPRAQAV-VGDLLELHCEALRGS 686 G+Y+CEA N A HS+ +L+V V P+ R V G L CE Sbjct: 854 AGHYTCEALNQ--AGHSEKHYNLNVWVA---PVFPLRESHTLTVREGHPTRLSCECRGVP 908 Query: 687 SPILYW------FYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEM 740 P + W E L +SA G + G Y+CE N + S+ Sbjct: 909 FPKISWRKDGQPLPGEGAGLQHVSAV--GRLLYLGQAQLAQEGTYTCECSN-VVGNSSQD 965 Query: 741 VTLKVAVPVSRPVLTLRAPGTHAAV--GDLLELHCEALRGSPLILYRFFHEDVTLGNRSS 798 + L+V VP + R P T +V + L C A P R Sbjct: 966 LQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPP---------PTVTWERDG 1014 Query: 799 PSGGASLNLSLT------------AEHSGNYSCEADNGLG 826 GA L L L A H+G YSC A+N G Sbjct: 1015 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1054 Score = 76.3 bits (186), Expect = 1e-13 Identities = 185/837 (22%), Positives = 290/837 (34%), Gaps = 141/837 (16%) Query: 79 ESGEYRCQAQGSPLSSPVHLDFSSASLILQAP---------LSVFEGDSVVLRCRAKAEV 129 +SG Y C A S V D L + P +SV +SV L C++ A Sbjct: 762 DSGRYSCVAV-----SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMP 816 Query: 130 TLNNTIYKNDNVLA------FLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKI 183 + +K+ L + + A + D G Y C ++ + + Sbjct: 817 PPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876 Query: 184 QVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTL-GLGWSL 241 V F P+ + + G+P L+CE + VP + + +D Q L G G L Sbjct: 877 WVAPVF--PLRESHTLTVREGHPTRLSCECR------GVPFPKISWRKDGQPLPGEGAGL 928 Query: 242 SPNFQITAMWS------KDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEK 295 + + G Y C+ + + V + S ++V +P P + Sbjct: 929 QHVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQ 985 Query: 296 ALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTE------- 348 + TL C T+ + +G P+ GA + L + Sbjct: 986 VSVVQDGVATLECNATGKPPPTV-TWERDGQPV---------GAELGLQLQNQGQSLHVE 1035 Query: 349 -----NSGNYYCTADNGLGAKPSKAVSLSVTVPVS-----HPVLNLSSPEDLIFEGAKVT 398 ++G Y C A+N L + + LSV VP P+ N+++ + +T Sbjct: 1036 RAQAAHTGRYSCVAEN-LAGRAERKFELSVLVPPELIGDLDPLTNITAALH-----SPLT 1089 Query: 399 LHCEAQRGSLPILYQFHHEGAALERRSANS-AGGVAISFSLTAEH-SGNYYCTADNGFGP 456 L CEA P + F E AGG + + T E SG Y C A N G Sbjct: 1090 LLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE 1149 Query: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516 R + S+ V VP S L + +G T L C V G PQ ++ + PL Sbjct: 1150 AR-RNFSVEVLVPPSIENEDLEEVIKV-LDGQTAHLMCNVT-GHPQPKLTWFKDGRPLAR 1206 Query: 517 SSTPSVGRVSFSFSLTEGH---SGNYYCTADNGFGPQRSEV-VSLFVTVPVSRPILTLRV 572 + + + + +G+Y C A N G + +S+ + + Sbjct: 1207 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1266 Query: 573 PRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTA------ 626 V + + L CEA P + W AP EAS N+ L Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITWM--------KDGAPF--EASRNIQLLPGTHGLQ 1316 Query: 627 ------EHSGNYSCEANNGLVAQHSDTISLSVIVPVS----RPILTFRAPRAQAVVGDLL 676 E +G Y+C N L + + V++P S P+ + V L Sbjct: 1317 ILNAQKEDAGQYTCVVTNEL-GEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTL 1375 Query: 677 ELHCEALRGSSPILYWFYH-EDVTLGKISAPSGGGASFNLSLT-TEHSGIYSCEADNGLE 734 L CE+ P + W+ + VT G G + T SG Y C A N Sbjct: 1376 TLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1435 Query: 735 AQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRG----------SPLILY 784 + L P+ + V G +A ++L EA G +P LY Sbjct: 1436 EDDQDFNVLIQVPPMFQKV------GDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489 Query: 785 -----------RFFHEDVTLGNRSSPS---GGASLNLSLT-AEHSGNYSCEADNGLG 826 ++ ED L S GG L + L AE++G YSC+A N +G Sbjct: 1490 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1546 Score = 75.5 bits (184), Expect = 2e-13 Identities = 188/748 (25%), Positives = 273/748 (36%), Gaps = 107/748 (14%) Query: 145 LNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPI-- 202 L++ H P D+G Y C E+ + + V P + VL A + Q + Sbjct: 83 LDEGQSLHFPRIQEGDSGLYSCRA--ENQAGTAQRDFHLLVLTPPS--VLGAGAAQEVLG 138 Query: 203 -SGNPVTLTCETQLSLERSDVPL-RFRFFRDDQTLGLGWSLSPNFQ---------ITAMW 251 +G V L C T S VP + + +D Q + G P+ Q IT Sbjct: 139 LAGADVELQCWT------SGVPTPQVEWTKDRQPVLPG---GPHLQVQEDGQVLRITGSH 189 Query: 252 SKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE--KALNFEGTKVTLHCE 309 D G Y C A +S R + Q+++ A P + S E + E V L CE Sbjct: 190 VGDEGRYQCVA----FSPAGQQARDF-QLRVHAP-PTIWGSNETGEVAVMEDHLVQLLCE 243 Query: 310 TQEDSLRTLYRFYHEG--VPLRHKSVRCERGASISFSLT-TENSGNYYCTADNGLGAKPS 366 + + ++ +G +P K V G + + ++G Y C A N +GA Sbjct: 244 ARGVPTPNI-TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA-E 301 Query: 367 KAVSLSVTVPVSHPVLNLSSPEDLIFE---GAKVTLHCEAQRGSLPILYQFHHEG--AAL 421 KA L V VP P + + + + G V L C A+ P L +HHEG A Sbjct: 302 KATRLDVYVP---PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL-SWHHEGLPVAE 357 Query: 422 ERRSANSAGGVAISFSLTAE-HSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSS- 479 S G + E SG Y C A + P + SV V V +L Sbjct: 358 SNESRLETDGSVLRLESPGEASSGLYSCVASS---PAGEAVLQYSVEVQVPPQLLVAEGL 414 Query: 480 AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP---LWSSSTPSVGRVSFSFSLTEGHS 536 + T G + L C+ GSP Q+ P L S G + HS Sbjct: 415 GQVTTIVGQPLELPCQAS-GSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHS 473 Query: 537 GNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPI 596 G + C A N G +EV V+V L VP Q G E H P P Sbjct: 474 GLFACQATNEAGTAGAEVE---VSVHGEWAPGVLEVPIGQYHWGX--EHHSSFPAACDPP 528 Query: 597 LY--WFYHEDVTLGSS--------SAPSGGEASFNL-------SLTAEHSGNYSCEANNG 639 ++ W H L P+G +++L + G Y+C A N Sbjct: 529 VHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATN- 587 Query: 640 LVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDL-LELHCEALRGSSPILYWFY-HED 697 L + ++L V+VP + P +AV+ + + L C A P + WF H+ Sbjct: 588 LAGESKREVALKVLVPPNIE----PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 643 Query: 698 VTLGKISAPSGGGASFNLSLTT-EHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTL 756 V+ S G + +G Y C A N + L+V VP R L Sbjct: 644 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELRYGLRVNVP-PRITLPP 701 Query: 757 RAPGTHAAVGDLLELHCEALRG-SPLILYRFFHEDVTLGNRSSPSGGASLNL-------- 807 PG V + L C A SP +++ + GN SP+G L + Sbjct: 702 SLPGP-VLVNTPVRLTCNATGAPSPTLMW------LKDGNPVSPAGTPGLQVFPGGRVLT 754 Query: 808 --SLTAEHSGNYSCEADNGLGAQRSETV 833 S A SG YSC A + +G R + V Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVV 782 Score = 69.7 bits (169), Expect = 1e-11 Identities = 113/488 (23%), Positives = 193/488 (39%), Gaps = 39/488 (7%) Query: 162 GAYRCTGYKESCCPVSSNTVKIQVQ-EPFTRPVLRASSFQPISGNPVTLTCETQLSLERS 220 G Y C+ + V+ V + VQ P +P+ S + ++ V L CE + R Sbjct: 2641 GRYTCSA--RNSAGVAHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEAS-GIPRP 2695 Query: 221 DVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS--KDSGFYWCKAATMPYSVISDSPRSWI 278 + + + G+ + P Q+ + +D+G Y C A S + ++ + Sbjct: 2696 TITWQKEGL--NVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMG---KTRL 2750 Query: 279 QVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPL---RHKSVRC 335 VQ+P PV+ EG+ L C+ + S + +G P+ K Sbjct: 2751 VVQVP---PVIENGLPDLSTTEGSHAFLPCKAR-GSPEPNITWDKDGQPVSGAEGKFTIQ 2806 Query: 336 ERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA 395 G + +L +++G Y CTA+N +G + + V L++ V PV + + G Sbjct: 2807 PSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVL---PVFTTLPGDRSLRLGD 2862 Query: 396 KVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFG 455 ++ L C A+ P + ++ E S G +++ E SG Y C A+N G Sbjct: 2863 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 2922 Query: 456 PQRSKAVSLSVTVPVSHPVLTLSSAEALTFE--GATVTLHCEVQRGSPQILYQFYHEDMP 513 R++AVS V V + A + E G ++ L C V RG P + + +P Sbjct: 2923 --RTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLP 2976 Query: 514 LWSSSTP-SVGRVSFSFSLTE-GHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLR 571 L S + S + TE +G Y C A+N G + V + V S P+ + Sbjct: 2977 LRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVV----ILVLQSAPVFQVE 3032 Query: 572 VPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNL-SLTAEHSG 630 GD + L C+A P + W S + + S L ++ +G Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3092 Query: 631 NYSCEANN 638 Y C A+N Sbjct: 3093 TYDCVAHN 3100 Score = 41.2 bits (95), Expect = 0.005 Identities = 72/314 (22%), Positives = 119/314 (37%), Gaps = 40/314 (12%) Query: 75 LEVQESGEYRCQAQGSP--LSSPVHLDFSSASLILQAP--LSVFEGDSVVLRCRAKAEVT 130 LE Q++G Y C A+ + VHL + P S+ GD + LRC A+ T Sbjct: 2816 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 2875 Query: 131 LNNTIYKNDNVLAFLNKRTD----FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQ 186 ND + D +D+G Y C + E+ + + V+ Sbjct: 2876 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC--WAENRVGRTQAVSFVHVK 2933 Query: 187 EPFTRPVLRASSF----QPISGNPVTLTCETQ------LSLERSDVPLRFRFFRDDQTLG 236 E PVL+ +F +P+ G+ + L C + + + +PLR R G Sbjct: 2934 EA---PVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG 2989 Query: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296 + I D+G Y C A + + + S PV + P+ Sbjct: 2990 -------SLTIRRTERDDAGRYQCLAEN------EMGVAKKVVILVLQSAPVFQVEPQDM 3036 Query: 297 LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLR-HKSVRCERGASISF-SLTTENSGNYY 354 G V L C+ + T+ + G PLR + +R S+ ++ T ++G Y Sbjct: 3037 TVRSGDDVALRCQATGEPTPTI-EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 3095 Query: 355 CTADNGLGAKPSKA 368 C A N LG+ ++A Sbjct: 3096 CVAHNLLGSATARA 3109 Score = 32.0 bits (71), Expect = 2.9 Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 9/74 (12%) Query: 802 GASLNLSLTAE-HSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIA 860 G SL+ E SG YSC A+N G + + L +T P + AG + Sbjct: 86 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT--------PPSVLGAGAAQEVL 137 Query: 861 GLAAGALLLYCWLS 874 GLA + L CW S Sbjct: 138 GLAGADVELQCWTS 151 >gi|189083842 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) isoform d precursor [Homo sapiens] Length = 253 Score = 106 bits (264), Expect = 1e-22 Identities = 89/271 (32%), Positives = 128/271 (47%), Gaps = 35/271 (12%) Query: 3 LWVILL----VLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQ--KTK 56 +W +LL +L +G P+ ++FL+P W V + + VTL C+G YSP+ T+ Sbjct: 1 MWQLLLPTALLLLVSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQG--AYSPEDNSTQ 58 Query: 57 WYHRYLGKEILRETPDNIL----EVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS 112 W+H + ++ + V +SGEYRCQ S LS PV L+ L+LQAP Sbjct: 59 WFH---NESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRW 115 Query: 113 VF-EGDSVVLRCRAKAEVTLNNTIY-KNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYK 170 VF E D + LRC + L+ Y +N + + +DF+IP A LKD+G+Y C G Sbjct: 116 VFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLF 175 Query: 171 ESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFR 230 S VSS TV I + + V SSF P G V+ C + L D Sbjct: 176 GS-KNVSSETVNITITQGLA--VSTISSFFP-PGYQVSF-CLVMVLLFAVDT-------- 222 Query: 231 DDQTLGLGWSLSPNFQITAMWSKDSGFYWCK 261 GL +S+ N + + KD F W K Sbjct: 223 -----GLYFSVKTNIRSSTRDWKDHKFKWRK 248 Score = 33.5 bits (75), Expect = 1.00 Identities = 44/203 (21%), Positives = 91/203 (44%), Gaps = 19/203 (9%) Query: 92 LSSPVHLDFSSASLILQAP-LSVFEGDSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRT 149 +S+ + D A + L+ V E DSV L+C+ N+T + N+++++ ++ + Sbjct: 14 VSAGMRTDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLIS--SQAS 71 Query: 150 DFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTL 209 + I A + D+G YRC ++ S+ V+++V + +L+A + +P+ L Sbjct: 72 SYFIDAATVDDSGEYRC----QTNLSTLSDPVQLEVHIGWL--LLQAPRWVFKEEDPIHL 125 Query: 210 TCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSV 269 C + + V + + + + +F I KDSG Y+C+ +V Sbjct: 126 RCHSWKNTALHKVT-----YLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNV 180 Query: 270 ISDSPRSWIQVQIPASHPVLTLS 292 S++ + + I V T+S Sbjct: 181 SSET----VNITITQGLAVSTIS 199 >gi|4503675 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide precursor [Homo sapiens] Length = 257 Score = 103 bits (257), Expect = 8e-22 Identities = 64/173 (36%), Positives = 90/173 (52%), Gaps = 10/173 (5%) Query: 2 LLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRY 61 LL V LL AP G A +P + L PPW +F+GE VTLTC G F+ TKW+H Sbjct: 10 LLCVALLFFAP-DGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFH-- 66 Query: 62 LGKEILRETPDNI----LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS-VFEG 116 + ET ++ + ++SGEY+CQ Q S PV+L+ S L+LQA V EG Sbjct: 67 -NGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEG 125 Query: 117 DSVVLRCRAKAEVTLNNTI-YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTG 168 + LRC + I YK+ L + + + I +A ++D+G Y CTG Sbjct: 126 QPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTG 178 Score = 42.4 bits (98), Expect = 0.002 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 22/181 (12%) Query: 113 VFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKES 172 +F+G++V L C +++T + ++ L+ + +I +A +D+G Y+C + + Sbjct: 41 IFKGENVTLTCNGNNFFEVSSTKWFHNGSLSE-ETNSSLNIVNAKFEDSGEYKCQHQQVN 99 Query: 173 CCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDD 232 S V ++V + +L+AS+ + G P+ L C DV + +++D Sbjct: 100 ----ESEPVYLEVFSDWL--LLQASAEVVMEGQPLFLRCH---GWRNWDV-YKVIYYKDG 149 Query: 233 QTLGLGWSLSPNFQITAMWSKDSGFYWC--KAATMPYS------VISDSPRS--WIQVQI 282 + L W + N IT +DSG Y+C K + Y + +PR W+Q I Sbjct: 150 EALKY-WYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFI 208 Query: 283 P 283 P Sbjct: 209 P 209 Score = 37.0 bits (84), Expect = 0.090 Identities = 46/165 (27%), Positives = 69/165 (41%), Gaps = 19/165 (11%) Query: 380 PVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLT 439 P ++L+ P + IF+G VTL C ++ H G +L + +S V F Sbjct: 30 PKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNG-SLSEETNSSLNIVNAKF--- 85 Query: 440 AEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRG 499 E SG Y C S+ V L V S +L +SAE + EG + L C R Sbjct: 86 -EDSGEYKCQHQQ---VNESEPVYLEV---FSDWLLLQASAE-VVMEGQPLFLRCHGWRN 137 Query: 500 SP--QILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCT 542 +++Y E + W + +S + + E SG YYCT Sbjct: 138 WDVYKVIYYKDGEALKYWYEN----HNISITNATVE-DSGTYYCT 177 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.132 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 40,044,295 Number of Sequences: 37866 Number of extensions: 1946179 Number of successful extensions: 8722 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 74 Number of HSP's successfully gapped in prelim test: 277 Number of HSP's that attempted gapping in prelim test: 5143 Number of HSP's gapped (non-prelim): 2116 length of query: 977 length of database: 18,247,518 effective HSP length: 112 effective length of query: 865 effective length of database: 14,006,526 effective search space: 12115644990 effective search space used: 12115644990 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.