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Search of human proteins with 110349738
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110349738 serine/threonine kinase 24 isoform b [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 864 0.0
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 837 0.0
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 608 e-174
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 598 e-171
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 441 e-124
gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Hom... 395 e-110
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 310 2e-84
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 310 2e-84
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 262 5e-70
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 257 1e-68
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 256 2e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 256 2e-68
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 253 2e-67
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 253 2e-67
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 253 2e-67
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 253 2e-67
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 253 2e-67
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 253 2e-67
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 253 2e-67
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 253 2e-67
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 249 3e-66
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 249 3e-66
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 249 3e-66
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 249 3e-66
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 243 2e-64
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 243 2e-64
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 243 3e-64
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 243 3e-64
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 243 3e-64
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 241 9e-64
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 864 bits (2233), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 60
MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA
Sbjct: 1 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 120
EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ
Sbjct: 61 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 120
Query: 121 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 180
IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE 240
GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE
Sbjct: 181 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE 240
Query: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH 300
GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH
Sbjct: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH 300
Query: 301 DDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPF 360
DDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPF
Sbjct: 301 DDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPF 360
Query: 361 SQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQR 420
SQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQR
Sbjct: 361 SQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQR 420
Query: 421 YSLSGGGTSSH 431
YSLSGGGTSSH
Sbjct: 421 YSLSGGGTSSH 431
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 837 bits (2163), Expect = 0.0
Identities = 418/420 (99%), Positives = 418/420 (99%)
Query: 12 GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 71
G NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI
Sbjct: 24 GSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 83
Query: 72 TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKG 131
TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKG
Sbjct: 84 TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKG 143
Query: 132 LDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI 191
LDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI
Sbjct: 144 LDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI 203
Query: 192 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFV 251
KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFV
Sbjct: 204 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFV 263
Query: 252 EACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAE 311
EACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAE
Sbjct: 264 EACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAE 323
Query: 312 TDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPL 371
TDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPL
Sbjct: 324 TDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPL 383
Query: 372 FAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH 431
FAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
Sbjct: 384 FAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH 443
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 608 bits (1569), Expect = e-174
Identities = 304/411 (73%), Positives = 349/411 (84%), Gaps = 6/411 (1%)
Query: 14 QNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITV 73
Q+ + DPEELFTKL++IGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITV
Sbjct: 10 QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 69
Query: 74 LSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLD 133
LSQCDSPY+T+Y+GSYLK TKLWIIMEYLGGGSALDLL+PGPL+ET IATILREILKGLD
Sbjct: 70 LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 129
Query: 134 YLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 193
YLHSE+KIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ
Sbjct: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
Query: 194 SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEA 253
SAYD KADIWSLGITAIELA+GEPP+S+LHPM+VLFLIPKN+PPTLEG +SKP KEFVEA
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEA 249
Query: 254 CLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETD 313
CLNK+P FRPTAKELLKHKFI R KKTS+LTELIDRYKRWK+E ++SSSEDSD D
Sbjct: 250 CLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSD--ID 307
Query: 314 GQASGGSDSGDWIF--TIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPL 371
G+A G W F TIR L G S + + + ++P SQCLST++ P+
Sbjct: 308 GEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHS--SQKPAEPVKRQPRSQCLSTLVRPV 365
Query: 372 FAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 422
F ELKEK + GG++G++EEL A LAEE+CPGISD ++ LV+R+QR+S
Sbjct: 366 FGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 598 bits (1542), Expect = e-171
Identities = 310/425 (72%), Positives = 358/425 (84%), Gaps = 17/425 (4%)
Query: 1 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 60
MAHSPV +PGMQN ADPEELFTKLE+IGKGSFGEVFKGIDNRTQ+VVAIKIIDLEEA
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 120
EDEIEDIQQEITVLSQCDS YVTKYYGSYLK +KLWIIMEYLGGGSALDLL GP DE Q
Sbjct: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
Query: 121 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 180
IAT+L+EILKGLDYLHSEKKIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE 240
GTPFWMAPEVI+QSAYDSKADIWSLGITAIELA+GEPP+S++HPM+VLFLIPKNNPPTL
Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV 240
Query: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAE-QS 299
G+++K KEF++ACLNK+PSFRPTAKELLKHKFI++N+KKTSYLTELIDR+KRWKAE S
Sbjct: 241 GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 300 HDDSSSEDSDAETDGQASGGSDSGDWIF-TIREK-DPKNLENGALQPSDLDRNKMKDIPK 357
D+S SE SD+E+ + + + +W F T+R+K DPK ++NGA Q DL +
Sbjct: 301 DDESDSEGSDSESTSREN--NTHPEWSFTTVRKKPDPKKVQNGAEQ--DLVQT------- 349
Query: 358 RPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQR 417
CLS II+P FAELK++ + +IEEL +I +AE ACPGI+D MV +L+++
Sbjct: 350 ---LSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEK 406
Query: 418 LQRYS 422
Q+ S
Sbjct: 407 FQKCS 411
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 441 bits (1133), Expect = e-124
Identities = 228/336 (67%), Positives = 275/336 (81%), Gaps = 17/336 (5%)
Query: 90 LKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAAN 149
++ +KLWIIMEYLGGGSALDLL GP DE QIAT+L+EILKGLDYLHSEKKIHRDIKAAN
Sbjct: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
Query: 150 VLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITA 209
VLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+QSAYDSKADIWSLGITA
Sbjct: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
Query: 210 IELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELL 269
IELA+GEPP+S++HPM+VLFLIPKNNPPTL G+++K KEF++ACLNK+PSFRPTAKELL
Sbjct: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
Query: 270 KHKFILRNAKKTSYLTELIDRYKRWKAE-QSHDDSSSEDSDAETDGQASGGSDSGDWIF- 327
KHKFI++N+KKTSYLTELIDR+KRWKAE S D+S SE SD+E+ + + + +W F
Sbjct: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN--NTHPEWSFT 250
Query: 328 TIREK-DPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNL 386
T+R+K DPK ++NGA Q DL + CLS II+P FAELK++ +
Sbjct: 251 TVRKKPDPKKVQNGAEQ--DLVQT----------LSCLSMIITPAFAELKQQDENNASRN 298
Query: 387 GSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 422
+IEEL +I +AE ACPGI+D MV +L+++ Q+ S
Sbjct: 299 QAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 334
>gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Homo
sapiens]
Length = 354
Score = 395 bits (1014), Expect = e-110
Identities = 238/424 (56%), Positives = 279/424 (65%), Gaps = 77/424 (18%)
Query: 1 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 60
MAHSPV +PGMQN ADPEELFTKLE+IGKGSFGEVFKGIDNRTQ+VVAIKIIDLEEA
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 120
EDEIEDIQQEITVLSQCDS YVTKYYGSYLK +KLWIIMEYLGGGSALDLL GP DE Q
Sbjct: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
Query: 121 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 180
IAT+L+EILKGLDYLHSEKKIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE 240
GTPFWMAPEVI+QSAYDSK TA EL + + I KN+ T
Sbjct: 181 GTPFWMAPEVIQQSAYDSKRP------TAKELLKHK-------------FIVKNSKKT-- 219
Query: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH 300
L E ++ + K + + D +E S
Sbjct: 220 ----SYLTELIDR---------------------FKRWKAEGHSDDESD------SEGSD 248
Query: 301 DDSSSEDSDAETDGQASGGSDSGDWIF-TIREK-DPKNLENGALQPSDLDRNKMKDIPKR 358
+S+S +++ + W F T+R+K DPK ++NGA Q DL +
Sbjct: 249 SESTSRENNTHPE-----------WSFTTVRKKPDPKKVQNGAEQ--DLVQT-------- 287
Query: 359 PFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRL 418
CLS II+P FAELK++ + +IEEL +I +AE ACPGI+D MV +L+++
Sbjct: 288 --LSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKF 345
Query: 419 QRYS 422
Q+ S
Sbjct: 346 QKCS 349
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 310 bits (794), Expect = 2e-84
Identities = 160/306 (52%), Positives = 213/306 (69%), Gaps = 13/306 (4%)
Query: 15 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL 74
+L PEE+F LEK+G+GS+G VFK I + +VVAIK + +E ++++I +EI+++
Sbjct: 18 SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIM 74
Query: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGL 132
QCDSPYV KYYGSY K+T LWI+MEY G GS D+ L L E +IATIL+ LKGL
Sbjct: 75 QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134
Query: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 192
+YLH +KIHRDIKA N+LL+ G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI+
Sbjct: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 194
Query: 193 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEF 250
+ Y+ ADIWSLGIT+IE+A G+PP++++HPM+ +F+IP N PPT +S +F
Sbjct: 195 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDF 254
Query: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID-----RYKRWKAEQSHDDSSS 305
V+ CL K P R TA +LL+H FI +NAK S L +LI + KR + +Q +
Sbjct: 255 VKKCLVKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEE 313
Query: 306 EDSDAE 311
E+SD +
Sbjct: 314 ENSDED 319
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 310 bits (794), Expect = 2e-84
Identities = 158/308 (51%), Positives = 215/308 (69%), Gaps = 13/308 (4%)
Query: 15 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL 74
+L PEE+F LEK+G+GS+G V+K I T ++VAIK + +E ++++I +EI+++
Sbjct: 21 SLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIM 77
Query: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGL 132
QCDSP+V KYYGSY K+T LWI+MEY G GS D+ L L E +IATIL+ LKGL
Sbjct: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
Query: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 192
+YLH +KIHRDIKA N+LL+ G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI+
Sbjct: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 197
Query: 193 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEF 250
+ Y+ ADIWSLGITAIE+A G+PP++++HPM+ +F+IP N PPT +S +F
Sbjct: 198 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDF 257
Query: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID-----RYKRWKAEQSHDDSSS 305
V+ CL K P R TA +LL+H F+ R+AK S L +LI+ + KR +++Q D
Sbjct: 258 VKQCLVKSPEQRATATQLLQHPFV-RSAKGVSILRDLINEAMDVKLKRQESQQREVDQDD 316
Query: 306 EDSDAETD 313
E++ E +
Sbjct: 317 EENSEEDE 324
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 262 bits (669), Expect = 5e-70
Identities = 140/309 (45%), Positives = 199/309 (64%), Gaps = 13/309 (4%)
Query: 11 PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 70
PG + +P+E F +++IG G++G+V+K + T ++ AIK+I LE ED +QQE
Sbjct: 3 PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQE 61
Query: 71 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 129
I ++ C P + Y+GSYL+ KLWI ME+ GGGS D+ GPL E QIA + RE L
Sbjct: 62 IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETL 121
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
+GL YLHS+ K+HRDIK AN+LL+++G VKLADFGV+ Q+T T KR +F+GTP+WMAPE
Sbjct: 122 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE 181
Query: 190 VI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--N 242
V ++ Y+ D+W++GITAIELA +PP +LHPM+ LFL+ K+N PP L+
Sbjct: 182 VAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK 241
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD 302
+S FV+ L K P RPTA++LL+H F+ ++ + S EL+D+ HD
Sbjct: 242 WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHD- 299
Query: 303 SSSEDSDAE 311
+D D E
Sbjct: 300 --FDDDDPE 306
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 257 bits (657), Expect = 1e-68
Identities = 138/303 (45%), Positives = 199/303 (65%), Gaps = 16/303 (5%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + F L+++G G++G+V+K D T ++ A+KI+ L+ +D I +QQEIT+L +C
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-ISSLQQEITILRECR 69
Query: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHS 137
P V Y GSYL++ +LWI ME+ GGGS ++ GPL+E QIA + RE LKGL +LHS
Sbjct: 70 HPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHS 129
Query: 138 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---KQS 194
+ KIHRDIK AN+LL+ G+VKLADFGV+G+LT + KR +F+GTP+WMAPEV ++
Sbjct: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKG 189
Query: 195 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTL--EGNYSKPLKEF 250
Y+ D+W+LGITAIEL +PP LHPM+ L L+ K++ PP L + +++ F
Sbjct: 190 GYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHF 249
Query: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH-DDSSSEDSD 309
++ L K P RPTA++LL+H F + + + LT+L+D KA H S ED +
Sbjct: 250 LKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLD-----KASDPHLGTPSPEDCE 303
Query: 310 AET 312
ET
Sbjct: 304 LET 306
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 2e-68
Identities = 133/305 (43%), Positives = 192/305 (62%), Gaps = 9/305 (2%)
Query: 11 PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 70
P L+ +P++ + ++++G G++G+V+K + T ++ A+KII LE +D IQQE
Sbjct: 7 PAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQE 65
Query: 71 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 129
I ++ +C + Y+GSYL KLWI MEY GGGS D+ GPL E QIA + RE L
Sbjct: 66 IFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETL 125
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
+GL YLH++ K+HRDIK AN+LL++HG+VKLADFGVA ++T T KR +F+GTP+WMAPE
Sbjct: 126 QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPE 185
Query: 190 VI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--N 242
V K Y+ DIW++GITAIEL +PP +LHPM+ LFL+ K+N PP L+
Sbjct: 186 VAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTK 245
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD 302
+S FV+ L K P RPTA+ LL H F+ + + EL+D+ + +
Sbjct: 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTE 305
Query: 303 SSSED 307
+ +D
Sbjct: 306 ADDDD 310
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 2e-68
Identities = 133/305 (43%), Positives = 192/305 (62%), Gaps = 9/305 (2%)
Query: 11 PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 70
P L+ +P++ + ++++G G++G+V+K + T ++ A+KII LE +D IQQE
Sbjct: 7 PAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQE 65
Query: 71 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 129
I ++ +C + Y+GSYL KLWI MEY GGGS D+ GPL E QIA + RE L
Sbjct: 66 IFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETL 125
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
+GL YLH++ K+HRDIK AN+LL++HG+VKLADFGVA ++T T KR +F+GTP+WMAPE
Sbjct: 126 QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPE 185
Query: 190 VI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--N 242
V K Y+ DIW++GITAIEL +PP +LHPM+ LFL+ K+N PP L+
Sbjct: 186 VAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTK 245
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD 302
+S FV+ L K P RPTA+ LL H F+ + + EL+D+ + +
Sbjct: 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTE 305
Query: 303 SSSED 307
+ +D
Sbjct: 306 ADDDD 310
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 253 bits (647), Expect = 2e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 299 --SHDDSSSEDSDAETD 313
++ S SE+ + E D
Sbjct: 318 ETEYEYSGSEEEEEEND 334
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 249 bits (637), Expect = 3e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
Query: 300 HDDSSSEDSDAETDGQASGGSDS 322
+ S+ E D G S
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 249 bits (637), Expect = 3e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
Query: 300 HDDSSSEDSDAETDGQASGGSDS 322
+ S+ E D G S
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 249 bits (637), Expect = 3e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
Query: 300 HDDSSSEDSDAETDGQASGGSDS 322
+ S+ E D G S
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 249 bits (637), Expect = 3e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
Query: 300 HDDSSSEDSDAETDGQASGGSDS 322
+ S+ E D G S
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 243 bits (620), Expect = 2e-64
Identities = 125/299 (41%), Positives = 191/299 (63%), Gaps = 9/299 (3%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + + L+++G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
Query: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHS 137
+ Y+GSYL KLWI ME+ G GS D+ + G L E QI+ + RE+L+GL YLHS
Sbjct: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 138 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 194
+KKIHRDIK AN+L+++ GEV+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
Query: 195 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKN--NPPTL--EGNYSKPLKEF 250
Y+ DIWSLGITAIELA +PP ++HP++VLFL+ K+ PP L +G +S F
Sbjct: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Query: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 309
++ L K P RP+A ++L H+ + + + +L+D+ K S D E+ +
Sbjct: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPE 309
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 243 bits (620), Expect = 2e-64
Identities = 125/299 (41%), Positives = 191/299 (63%), Gaps = 9/299 (3%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + + L+++G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
Query: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHS 137
+ Y+GSYL KLWI ME+ G GS D+ + G L E QI+ + RE+L+GL YLHS
Sbjct: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 138 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 194
+KKIHRDIK AN+L+++ GEV+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
Query: 195 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKN--NPPTL--EGNYSKPLKEF 250
Y+ DIWSLGITAIELA +PP ++HP++VLFL+ K+ PP L +G +S F
Sbjct: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Query: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 309
++ L K P RP+A ++L H+ + + + +L+D+ K S D E+ +
Sbjct: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPE 309
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 243 bits (619), Expect = 3e-64
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 296
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
Query: 297 EQSHDDSSSEDSDAETDGQ 315
E ++ S SE+ + E Q
Sbjct: 318 ETEYEYSGSEEEEEEVPEQ 336
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 243 bits (619), Expect = 3e-64
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 296
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
Query: 297 EQSHDDSSSEDSDAETDGQ 315
E ++ S SE+ + E Q
Sbjct: 318 ETEYEYSGSEEEEEEVPEQ 336
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 243 bits (619), Expect = 3e-64
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
Query: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
Query: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
Query: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 296
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
Query: 297 EQSHDDSSSEDSDAETDGQ 315
E ++ S SE+ + E Q
Sbjct: 318 ETEYEYSGSEEEEEEVPEQ 336
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 241 bits (615), Expect = 9e-64
Identities = 129/302 (42%), Positives = 196/302 (64%), Gaps = 12/302 (3%)
Query: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP E++ + ++G G+FG+V+K + T + A K+I+ + +E+E+ED EI +L+ CD
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYIVEIEILATCD 89
Query: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGS--ALDLLEPGPLDETQIATILREILKGLDYLH 136
PY+ K G+Y D KLWI++E+ GG+ A+ L L E QI + R++L+ L++LH
Sbjct: 90 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 149
Query: 137 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----- 191
S++ IHRD+KA NVL++ G+++LADFGV+ + T KR++F+GTP+WMAPEV+
Sbjct: 150 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 209
Query: 192 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL--EGNYSKPLKE 249
K + YD KADIWSLGIT IE+A+ EPPH EL+PM+VL I K++PPTL +S ++
Sbjct: 210 KDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRD 269
Query: 250 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD-SSSEDS 308
F++ L+K P RP+A +LL+H F+ + L EL+ K E+ D E+
Sbjct: 270 FLKIALDKNPETRPSAAQLLEHPFV-SSITSNKALRELVAEAKAEVMEEIEDGRDEGEEE 328
Query: 309 DA 310
DA
Sbjct: 329 DA 330
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,243,358
Number of Sequences: 37866
Number of extensions: 787449
Number of successful extensions: 4931
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 767
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 2148
Number of HSP's gapped (non-prelim): 1073
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.