Guide to the Human Genome
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Search of human proteins with 156071462

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
         (298 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156071462 solute carrier family 25, member A6 [Homo sapiens]       598   e-171
gi|156071459 solute carrier family 25, member 5 [Homo sapiens]        565   e-161
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade...   547   e-156
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade...   434   e-122
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ...   137   1e-32
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s...   137   1e-32
gi|48476342 solute carrier family 25, member 23 [Homo sapiens]        119   2e-27
gi|239755176 PREDICTED: similar to solute carrier family 25, mem...   115   6e-26
gi|239755174 PREDICTED: similar to solute carrier family 25, mem...   115   6e-26
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ...   115   6e-26
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ...   115   6e-26
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ...   115   6e-26
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ...   115   6e-26
gi|60460887 solute carrier family 25, member 42 [Homo sapiens]        114   1e-25
gi|21361103 solute carrier family 25, member 12 [Homo sapiens]        110   1e-24
gi|27544933 solute carrier family 25, member 16 [Homo sapiens]        110   2e-24
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s...   107   1e-23
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo...   107   1e-23
gi|149274607 solute carrier family 25, member 41 [Homo sapiens]       106   3e-23
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho...   106   3e-23
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H...   106   3e-23
gi|58197562 solute carrier family 25, member 30 [Homo sapiens]        105   4e-23
gi|21687151 mitochondrial solute carrier protein [Homo sapiens]       104   1e-22
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]           99   5e-21
gi|21314739 solute carrier family 25, member 32 [Homo sapiens]         98   8e-21
gi|13899342 solute carrier [Homo sapiens]                              96   3e-20
gi|13259541 uncoupling protein 2 [Homo sapiens]                        95   8e-20
gi|86198310 solute carrier family 25, member 29 [Homo sapiens]         93   3e-19
gi|108860679 solute carrier family 25, member 27 [Homo sapiens]        92   4e-19
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]          91   2e-18

>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
          Length = 298

 Score =  598 bits (1543), Expect = e-171
 Identities = 298/298 (100%), Positives = 298/298 (100%)

Query: 1   MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR 60
           MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR
Sbjct: 1   MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR 60

Query: 61  IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG 120
           IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG
Sbjct: 61  IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG 120

Query: 121 GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS 180
           GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS
Sbjct: 121 GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS 180

Query: 181 VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMM 240
           VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMM
Sbjct: 181 VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMM 240

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 298
           QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
Sbjct: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 298


>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
          Length = 298

 Score =  565 bits (1456), Expect = e-161
 Identities = 274/296 (92%), Positives = 287/296 (96%)

Query: 1   MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR 60
           MT+ A+SFAKDFLAGG+AAAISKTAVAPIERVKLLLQVQHASKQI ADKQYKGI+DC+VR
Sbjct: 1   MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR 60

Query: 61  IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG 120
           IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDK TQFW YFAGNLASG
Sbjct: 61  IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASG 120

Query: 121 GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS 180
           GAAGATSLCFVYPLDFARTRLAADVGK+G EREFRGLGDCLVKI KSDGI+GLYQGF+VS
Sbjct: 121 GAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVS 180

Query: 181 VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMM 240
           VQGIIIYRAAYFG+YDTAKGMLPDPKNTHIV+SWMIAQTVTAVAG+ SYPFDTVRRRMMM
Sbjct: 181 VQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMM 240

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKK 296
           QSGRKG DIMYTGT+DCWRKI RDEGGKAFFKGAWSNVLRGMGGAFVLVLYDE+KK
Sbjct: 241 QSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKK 296


>gi|55749577 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 4 [Homo
           sapiens]
          Length = 298

 Score =  547 bits (1409), Expect = e-156
 Identities = 263/298 (88%), Positives = 282/298 (94%)

Query: 1   MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR 60
           M + A SF KDFLAGG+AAA+SKTAVAPIERVKLLLQVQHASKQI+A+KQYKGI+DC+VR
Sbjct: 1   MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVR 60

Query: 61  IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG 120
           IPKEQG LSFWRGNLANVIRYFPTQALNFAFKDKYKQ+FLGGVD+H QFWRYFAGNLASG
Sbjct: 61  IPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASG 120

Query: 121 GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS 180
           GAAGATSLCFVYPLDFARTRLAADVGK   +REF GLGDC++KI KSDG+RGLYQGF+VS
Sbjct: 121 GAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVS 180

Query: 181 VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMM 240
           VQGIIIYRAAYFGVYDTAKGMLPDPKN HI VSWMIAQ+VTAVAG+VSYPFDTVRRRMMM
Sbjct: 181 VQGIIIYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMM 240

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 298
           QSGRKGADIMYTGTVDCWRKI +DEG KAFFKGAWSNVLRGMGGAFVLVLYDE+KK +
Sbjct: 241 QSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV 298


>gi|13775208 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 31 [Homo
           sapiens]
          Length = 315

 Score =  434 bits (1117), Expect = e-122
 Identities = 211/292 (72%), Positives = 247/292 (84%), Gaps = 2/292 (0%)

Query: 5   AISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKE 64
           A SF KD LAGG+AAA+SKTAVAPIERVKLLLQVQ +SKQI+ + +YKG+VDC+VRIP+E
Sbjct: 17  ASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPRE 76

Query: 65  QGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAG 124
           QG  SFWRGNLANVIRYFPTQALNFAFKDKYKQ+F+ GV+K  QFWR+F  NLASGGAAG
Sbjct: 77  QGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAG 136

Query: 125 ATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGI 184
           ATSLC VYPLDFARTRL  D+GK   ER+F+GLGDC++KI KSDGI GLYQGF VSVQGI
Sbjct: 137 ATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGI 196

Query: 185 IIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGR 244
           I+YRA+YFG YDT KG+LP PK T  +VS+ IAQ VT  +G++SYPFDTVRRRMMMQSG 
Sbjct: 197 IVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGE 256

Query: 245 KGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKK 296
             A   Y GT+DC+ KI++ EG  +FF+GA+SNVLRG GGA VLVLYD++K+
Sbjct: 257 --AKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGTGGALVLVLYDKIKE 306


>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
           sapiens]
          Length = 477

 Score =  137 bits (345), Expect = 1e-32
 Identities = 94/295 (31%), Positives = 155/295 (52%), Gaps = 24/295 (8%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  LAGGIA A+S+T+ AP++R+K+++QV H SK   +DK    I     ++ KE G+ S
Sbjct: 196 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSK---SDKM--NIFGGFRQMVKEGGIRS 249

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NVI+  P  A+ F   ++YK++      K   F R+ +G++     AGAT+  
Sbjct: 250 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM-----AGATAQT 304

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
           F+YP++  +TRLA  VGK+G   ++ G+ DC  KI K +G+   Y+G+  ++ GII Y  
Sbjct: 305 FIYPMEVMKTRLA--VGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAG 359

Query: 190 AYFGVYDTAK-----GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGR 244
               VY+  K         D  N  ++V        +    + SYP   VR RM  Q+  
Sbjct: 360 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 419

Query: 245 KGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELKKVI 298
           +G+  +    V  +R+I   EG    ++G   N ++ +    +  V+Y+ +K+ +
Sbjct: 420 EGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 472


>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
           sapiens]
          Length = 458

 Score =  137 bits (345), Expect = 1e-32
 Identities = 94/295 (31%), Positives = 155/295 (52%), Gaps = 24/295 (8%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  LAGGIA A+S+T+ AP++R+K+++QV H SK   +DK    I     ++ KE G+ S
Sbjct: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSK---SDKM--NIFGGFRQMVKEGGIRS 230

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NVI+  P  A+ F   ++YK++      K   F R+ +G++     AGAT+  
Sbjct: 231 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM-----AGATAQT 285

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
           F+YP++  +TRLA  VGK+G   ++ G+ DC  KI K +G+   Y+G+  ++ GII Y  
Sbjct: 286 FIYPMEVMKTRLA--VGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAG 340

Query: 190 AYFGVYDTAK-----GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGR 244
               VY+  K         D  N  ++V        +    + SYP   VR RM  Q+  
Sbjct: 341 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 400

Query: 245 KGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELKKVI 298
           +G+  +    V  +R+I   EG    ++G   N ++ +    +  V+Y+ +K+ +
Sbjct: 401 EGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453


>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
          Length = 468

 Score =  119 bits (299), Expect = 2e-27
 Identities = 88/296 (29%), Positives = 151/296 (51%), Gaps = 26/296 (8%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           K  +AG +A A+S+T  AP++R+K+ +QV HASK          I+  +  +  E G+ S
Sbjct: 187 KQLVAGAVAGAVSRTGTAPLDRLKVFMQV-HASK-----TNRLNILGGLRSMVLEGGIRS 240

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  LG  +      R+ AG+L     AGAT+  
Sbjct: 241 LWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSL-----AGATAQT 295

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TRL   + ++G   +++GL DC  +I + +G R  Y+G+  +V GII Y  
Sbjct: 296 IIYPMEVLKTRLT--LRRTG---QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAG 350

Query: 190 AYFGVYDTAKG-----MLPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMMQSG 243
               VY+T K         D  +  I+V  +   T+++  G + SYP   VR RM  Q+ 
Sbjct: 351 IDLAVYETLKNWWLQQYSHDSADPGILV-LLACGTISSTCGQIASYPLALVRTRMQAQAS 409

Query: 244 RKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELKKVI 298
            +G   +    +   R I   EG +  ++G   N ++ +    +  V+Y+ +K+ +
Sbjct: 410 IEGGPQL--SMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQAL 463



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 56/201 (27%), Positives = 93/201 (46%), Gaps = 12/201 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   + F+AG +A A ++T + P+E +K  L ++          QYKG++DC  RI 
Sbjct: 274 QETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTG-------QYKGLLDCARRIL 326

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
           + +G  +F+RG L NV+   P   ++ A  +  K  +L     H          LA G  
Sbjct: 327 EREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQY-SHDSADPGILVLLACGTI 385

Query: 123 AGATSLCFVYPLDFARTRLAADVG-KSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSV 181
           +        YPL   RTR+ A    + G +    GL   L  I   +G+RGLY+G + + 
Sbjct: 386 SSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGL---LRHILSQEGMRGLYRGIAPNF 442

Query: 182 QGIIIYRAAYFGVYDTAKGML 202
             +I   +  + VY+  K  L
Sbjct: 443 MKVIPAVSISYVVYENMKQAL 463


>gi|239755176 PREDICTED: similar to solute carrier family 25, member
           25 isoform 2 [Homo sapiens]
          Length = 469

 Score =  115 bits (287), Expect = 6e-26
 Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 32/296 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  +AGG A A+S+T  AP++R+K+L+QV HAS+         GIV    ++ +E G  S
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV-HASRS-----NNMGIVGGFTQMIREGGARS 241

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  L G D+ T         L +G  AGA +  
Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKR--LVGSDQET---LRIHERLVAGSLAGAIAQS 296

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TR+A  + K+G   ++ G+ DC  +I   +G+   Y+G+  ++ GII Y  
Sbjct: 297 SIYPMEVLKTRMA--LRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 351

Query: 190 AYFGVYDTAKGM--------LPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMM 240
               VY+T K            DP     V   +   T+++  G + SYP   VR RM  
Sbjct: 352 IDLAVYETLKNAWLQHYAVNSADPG----VFVLLACGTMSSTCGQLASYPLALVRTRMQA 407

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELK 295
           Q+  +GA  +   ++  ++ I R EG    ++G   N ++ +    +  V+Y+ LK
Sbjct: 408 QASIEGAPEVTMSSL--FKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/197 (23%), Positives = 90/197 (45%), Gaps = 10/197 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   +  +AG +A AI+++++ P+E +K  + ++          QY G++DC  RI 
Sbjct: 275 QETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG-------QYSGMLDCARRIL 327

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
             +GV +F++G + N++   P   ++ A  +  K  +L     ++     F   LA G  
Sbjct: 328 AREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTM 386

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQ 182
           +        YPL   RTR+ A     G       +      I +++G  GLY+G + +  
Sbjct: 387 SSTCGQLASYPLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFM 444

Query: 183 GIIIYRAAYFGVYDTAK 199
            +I   +  + VY+  K
Sbjct: 445 KVIPAVSISYVVYENLK 461


>gi|239755174 PREDICTED: similar to solute carrier family 25, member
           25 isoform 1 [Homo sapiens]
          Length = 503

 Score =  115 bits (287), Expect = 6e-26
 Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 32/296 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  +AGG A A+S+T  AP++R+K+L+QV HAS+         GIV    ++ +E G  S
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV-HASRS-----NNMGIVGGFTQMIREGGARS 275

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  L G D+ T         L +G  AGA +  
Sbjct: 276 LWRGNGINVLKIAPESAIKFMAYEQIKR--LVGSDQET---LRIHERLVAGSLAGAIAQS 330

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TR+A  + K+G   ++ G+ DC  +I   +G+   Y+G+  ++ GII Y  
Sbjct: 331 SIYPMEVLKTRMA--LRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 385

Query: 190 AYFGVYDTAKGM--------LPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMM 240
               VY+T K            DP     V   +   T+++  G + SYP   VR RM  
Sbjct: 386 IDLAVYETLKNAWLQHYAVNSADPG----VFVLLACGTMSSTCGQLASYPLALVRTRMQA 441

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELK 295
           Q+  +GA  +   ++  ++ I R EG    ++G   N ++ +    +  V+Y+ LK
Sbjct: 442 QASIEGAPEVTMSSL--FKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/197 (23%), Positives = 90/197 (45%), Gaps = 10/197 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   +  +AG +A AI+++++ P+E +K  + ++          QY G++DC  RI 
Sbjct: 309 QETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG-------QYSGMLDCARRIL 361

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
             +GV +F++G + N++   P   ++ A  +  K  +L     ++     F   LA G  
Sbjct: 362 AREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTM 420

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQ 182
           +        YPL   RTR+ A     G       +      I +++G  GLY+G + +  
Sbjct: 421 SSTCGQLASYPLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFM 478

Query: 183 GIIIYRAAYFGVYDTAK 199
            +I   +  + VY+  K
Sbjct: 479 KVIPAVSISYVVYENLK 495


>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
           sapiens]
          Length = 489

 Score =  115 bits (287), Expect = 6e-26
 Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 32/296 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  +AGG A A+S+T  AP++R+K+L+QV HAS+         GIV    ++ +E G  S
Sbjct: 208 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV-HASRS-----NNMGIVGGFTQMIREGGARS 261

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  L G D+ T         L +G  AGA +  
Sbjct: 262 LWRGNGINVLKIAPESAIKFMAYEQIKR--LVGSDQET---LRIHERLVAGSLAGAIAQS 316

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TR+A  + K+G   ++ G+ DC  +I   +G+   Y+G+  ++ GII Y  
Sbjct: 317 SIYPMEVLKTRMA--LRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 371

Query: 190 AYFGVYDTAKGM--------LPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMM 240
               VY+T K            DP     V   +   T+++  G + SYP   VR RM  
Sbjct: 372 IDLAVYETLKNAWLQHYAVNSADPG----VFVLLACGTMSSTCGQLASYPLALVRTRMQA 427

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELK 295
           Q+  +GA  +   ++  ++ I R EG    ++G   N ++ +    +  V+Y+ LK
Sbjct: 428 QASIEGAPEVTMSSL--FKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 481



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/197 (23%), Positives = 90/197 (45%), Gaps = 10/197 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   +  +AG +A AI+++++ P+E +K  + ++          QY G++DC  RI 
Sbjct: 295 QETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG-------QYSGMLDCARRIL 347

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
             +GV +F++G + N++   P   ++ A  +  K  +L     ++     F   LA G  
Sbjct: 348 AREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTM 406

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQ 182
           +        YPL   RTR+ A     G       +      I +++G  GLY+G + +  
Sbjct: 407 SSTCGQLASYPLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFM 464

Query: 183 GIIIYRAAYFGVYDTAK 199
            +I   +  + VY+  K
Sbjct: 465 KVIPAVSISYVVYENLK 481


>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
           sapiens]
          Length = 469

 Score =  115 bits (287), Expect = 6e-26
 Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 32/296 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  +AGG A A+S+T  AP++R+K+L+QV HAS+         GIV    ++ +E G  S
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV-HASRS-----NNMGIVGGFTQMIREGGARS 241

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  L G D+ T         L +G  AGA +  
Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKR--LVGSDQET---LRIHERLVAGSLAGAIAQS 296

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TR+A  + K+G   ++ G+ DC  +I   +G+   Y+G+  ++ GII Y  
Sbjct: 297 SIYPMEVLKTRMA--LRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 351

Query: 190 AYFGVYDTAKGM--------LPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMM 240
               VY+T K            DP     V   +   T+++  G + SYP   VR RM  
Sbjct: 352 IDLAVYETLKNAWLQHYAVNSADPG----VFVLLACGTMSSTCGQLASYPLALVRTRMQA 407

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELK 295
           Q+  +GA  +   ++  ++ I R EG    ++G   N ++ +    +  V+Y+ LK
Sbjct: 408 QASIEGAPEVTMSSL--FKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/197 (23%), Positives = 90/197 (45%), Gaps = 10/197 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   +  +AG +A AI+++++ P+E +K  + ++          QY G++DC  RI 
Sbjct: 275 QETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG-------QYSGMLDCARRIL 327

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
             +GV +F++G + N++   P   ++ A  +  K  +L     ++     F   LA G  
Sbjct: 328 AREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTM 386

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQ 182
           +        YPL   RTR+ A     G       +      I +++G  GLY+G + +  
Sbjct: 387 SSTCGQLASYPLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFM 444

Query: 183 GIIIYRAAYFGVYDTAK 199
            +I   +  + VY+  K
Sbjct: 445 KVIPAVSISYVVYENLK 461


>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
           sapiens]
          Length = 366

 Score =  115 bits (287), Expect = 6e-26
 Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 32/296 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  +AGG A A+S+T  AP++R+K+L+QV HAS+         GIV    ++ +E G  S
Sbjct: 85  RHLVAGGGAGAVSRTCTAPLDRLKVLMQV-HASRS-----NNMGIVGGFTQMIREGGARS 138

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  L G D+ T         L +G  AGA +  
Sbjct: 139 LWRGNGINVLKIAPESAIKFMAYEQIKR--LVGSDQET---LRIHERLVAGSLAGAIAQS 193

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TR+A  + K+G   ++ G+ DC  +I   +G+   Y+G+  ++ GII Y  
Sbjct: 194 SIYPMEVLKTRMA--LRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 248

Query: 190 AYFGVYDTAKGM--------LPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMM 240
               VY+T K            DP     V   +   T+++  G + SYP   VR RM  
Sbjct: 249 IDLAVYETLKNAWLQHYAVNSADPG----VFVLLACGTMSSTCGQLASYPLALVRTRMQA 304

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELK 295
           Q+  +GA  +   ++  ++ I R EG    ++G   N ++ +    +  V+Y+ LK
Sbjct: 305 QASIEGAPEVTMSSL--FKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 358



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/197 (23%), Positives = 90/197 (45%), Gaps = 10/197 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   +  +AG +A AI+++++ P+E +K  + ++          QY G++DC  RI 
Sbjct: 172 QETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG-------QYSGMLDCARRIL 224

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
             +GV +F++G + N++   P   ++ A  +  K  +L     ++     F   LA G  
Sbjct: 225 AREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTM 283

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQ 182
           +        YPL   RTR+ A     G       +      I +++G  GLY+G + +  
Sbjct: 284 SSTCGQLASYPLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFM 341

Query: 183 GIIIYRAAYFGVYDTAK 199
            +I   +  + VY+  K
Sbjct: 342 KVIPAVSISYVVYENLK 358


>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
           sapiens]
          Length = 503

 Score =  115 bits (287), Expect = 6e-26
 Identities = 89/296 (30%), Positives = 149/296 (50%), Gaps = 32/296 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           +  +AGG A A+S+T  AP++R+K+L+QV HAS+         GIV    ++ +E G  S
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV-HASRS-----NNMGIVGGFTQMIREGGARS 275

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F   ++ K+  L G D+ T         L +G  AGA +  
Sbjct: 276 LWRGNGINVLKIAPESAIKFMAYEQIKR--LVGSDQET---LRIHERLVAGSLAGAIAQS 330

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            +YP++  +TR+A  + K+G   ++ G+ DC  +I   +G+   Y+G+  ++ GII Y  
Sbjct: 331 SIYPMEVLKTRMA--LRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 385

Query: 190 AYFGVYDTAKGM--------LPDPKNTHIVVSWMIAQTVTAVAG-VVSYPFDTVRRRMMM 240
               VY+T K            DP     V   +   T+++  G + SYP   VR RM  
Sbjct: 386 IDLAVYETLKNAWLQHYAVNSADPG----VFVLLACGTMSSTCGQLASYPLALVRTRMQA 441

Query: 241 QSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELK 295
           Q+  +GA  +   ++  ++ I R EG    ++G   N ++ +    +  V+Y+ LK
Sbjct: 442 QASIEGAPEVTMSSL--FKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/197 (23%), Positives = 90/197 (45%), Gaps = 10/197 (5%)

Query: 3   EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIP 62
           ++ +   +  +AG +A AI+++++ P+E +K  + ++          QY G++DC  RI 
Sbjct: 309 QETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG-------QYSGMLDCARRIL 361

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGA 122
             +GV +F++G + N++   P   ++ A  +  K  +L     ++     F   LA G  
Sbjct: 362 AREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTM 420

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQ 182
           +        YPL   RTR+ A     G       +      I +++G  GLY+G + +  
Sbjct: 421 SSTCGQLASYPLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFM 478

Query: 183 GIIIYRAAYFGVYDTAK 199
            +I   +  + VY+  K
Sbjct: 479 KVIPAVSISYVVYENLK 495


>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
          Length = 318

 Score =  114 bits (285), Expect = 1e-25
 Identities = 87/280 (31%), Positives = 138/280 (49%), Gaps = 33/280 (11%)

Query: 13  LAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWR 72
           L G +A A++KTAVAP++R K++ QV  +SK+ +A + ++ +    +     +G LS WR
Sbjct: 38  LPGALAGALAKTAVAPLDRTKIIFQV--SSKRFSAKEAFRVLYYTYLN----EGFLSLWR 91

Query: 73  GNLANVIRYFPTQALNFAFKDKYKQI---FLGGVDKHTQFW-RYFAGNLASGGAAGATSL 128
           GN A ++R  P  A+ F+  ++YK+I   + G   +    W R FAG L     AG T+ 
Sbjct: 92  GNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGAL-----AGTTAA 146

Query: 129 CFVYPLDFARTRLAADVGKSGTERE-FRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIY 187
              YPLD  R R+A       T +E +  +    ++I++ +G++ LY GF  +V G+I Y
Sbjct: 147 SLTYPLDLVRARMAV------TPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPY 200

Query: 188 RAAYFGVYDTAKGM---LPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQ--S 242
               F  Y+T K +       +  +     +       +    SYP D VRRRM     +
Sbjct: 201 AGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVT 260

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGG-KAFFKGAWSNVLRG 281
           G   A I  T      R I R+EG  +  +KG   N ++G
Sbjct: 261 GYPRASIART-----LRTIVREEGAVRGLYKGLSMNWVKG 295



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 41/174 (23%), Positives = 66/174 (37%), Gaps = 14/174 (8%)

Query: 111 RYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGI 170
           R    +L  G  AGA +   V PLD  +        +   +  FR     L     ++G 
Sbjct: 31  RQVLSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFR----VLYYTYLNEGF 86

Query: 171 RGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPD--PKNTHIVVSW---MIAQTVTAVAG 225
             L++G S ++  ++ Y A  F  ++  K +L          +  W            A 
Sbjct: 87  LSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAA 146

Query: 226 VVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVL 279
            ++YP D VR RM +         MY+     + +I R+EG K  + G    VL
Sbjct: 147 SLTYPLDLVRARMAVTPKE-----MYSNIFHVFIRISREEGLKTLYHGFMPTVL 195


>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
          Length = 678

 Score =  110 bits (276), Expect = 1e-24
 Identities = 88/301 (29%), Positives = 135/301 (44%), Gaps = 27/301 (8%)

Query: 4   QAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPK 63
           Q    A  F  G +A A+  TAV PI+ VK  +Q Q  S  +  +  YK   DC  ++ +
Sbjct: 322 QIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLR 381

Query: 64  EQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFL---GGVDKHTQFWRYFAGNLASG 120
            +G    +RG +  +I   P +A+     D  +  F    G V             + +G
Sbjct: 382 YEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVP--------LPAEVLAG 433

Query: 121 GAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVS 180
           G AG + + F  PL+  + RL    G+  T      L      + +  GI GLY+G    
Sbjct: 434 GCAGGSQVIFTNPLEIVKIRLQV-AGEITTGPRVSAL-----NVLRDLGIFGLYKGAKAC 487

Query: 181 VQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGV----VSYPFDTVRR 236
               I + A YF VY   K +L D +N H+    ++A    A+AGV    +  P D ++ 
Sbjct: 488 FLRDIPFSAIYFPVYAHCKLLLAD-ENGHVGGLNLLA--AGAMAGVPAASLVTPADVIKT 544

Query: 237 RMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGG-AFVLVLYDELK 295
           R  +Q   +     Y+G +DC+RKI R+EG  AF+KG  + V R        LV Y+ L+
Sbjct: 545 R--LQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQ 602

Query: 296 K 296
           +
Sbjct: 603 R 603


>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
          Length = 332

 Score =  110 bits (274), Expect = 2e-24
 Identities = 80/259 (30%), Positives = 120/259 (46%), Gaps = 38/259 (14%)

Query: 2   TEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYK--GIVDCIV 59
           T +   + + FLAGGIA   +KT VAP++RVK+LLQ        A +  YK  G+   + 
Sbjct: 30  TRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQ--------AHNHHYKHLGVFSALR 81

Query: 60  RIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG--GVDKHTQFWRYFAGNL 117
            +P+++G L  ++GN A +IR FP  A+ F   + YK +     G+  H          L
Sbjct: 82  AVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RL 134

Query: 118 ASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKI-TKSDGIRGLYQG 176
            +G  AG T++   YPLD  R RLA  V     E  + G+      I  K  G  G Y+G
Sbjct: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQV---KGEHSYTGIIHAFKTIYAKEGGFFGFYRG 191

Query: 177 FSVSVQGIIIYRAAYFGVYDTAKGM----------LPDPKNTHIV-----VSWMIAQTVT 221
              ++ G+  Y    F  + T K +           P   N +++     V+ +      
Sbjct: 192 LMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG 251

Query: 222 AVAGVVSYPFDTVRRRMMM 240
           A+A  +SYPFD  RRRM +
Sbjct: 252 AIAQTISYPFDVTRRRMQL 270



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 46/172 (26%), Positives = 78/172 (45%), Gaps = 13/172 (7%)

Query: 112 YFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLG--DCLVKITKSDG 169
           Y+  +  +GG AG  +   V PLD  +  L A          ++ LG    L  + + +G
Sbjct: 35  YWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH------NHHYKHLGVFSALRAVPQKEG 88

Query: 170 IRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVV-S 228
             GLY+G    +  I  Y A  F  ++  K ++         V  ++A ++  +  V+ +
Sbjct: 89  FLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICT 148

Query: 229 YPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGG-KAFFKGAWSNVL 279
           YP D VR R+  Q   KG +  YTG +  ++ I+  EGG   F++G    +L
Sbjct: 149 YPLDMVRVRLAFQV--KG-EHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTIL 197



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 49/198 (24%), Positives = 77/198 (38%), Gaps = 17/198 (8%)

Query: 13  LAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRI-PKEQGVLSFW 71
           +AG +A   +     P++ V++ L  Q     +  +  Y GI+     I  KE G   F+
Sbjct: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQ-----VKGEHSYTGIIHAFKTIYAKEGGFFGFY 189

Query: 72  RGNLANVIRYFPTQALNFAFKDKYKQIFLGGV---------DKHTQFWRYFAGNLASGGA 122
           RG +  ++   P   ++F      K + L            D           NL  GG 
Sbjct: 190 RGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGV 249

Query: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIR-GLYQGFSVSV 181
           AGA +    YP D  R R+         E+    + D +  +    GIR GLY+G S++ 
Sbjct: 250 AGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLT-MRDTMKYVYGHHGIRKGLYRGLSLNY 308

Query: 182 QGIIIYRAAYFGVYDTAK 199
              I  +A  F  Y+  K
Sbjct: 309 IRCIPSQAVAFTTYELMK 326



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 23/90 (25%), Positives = 42/90 (46%), Gaps = 4/90 (4%)

Query: 11  DFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS- 69
           + L GG+A AI++T   P +  +  +Q+     +    ++   + D +  +    G+   
Sbjct: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEF---EKCLTMRDTMKYVYGHHGIRKG 299

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIF 99
            +RG   N IR  P+QA+ F   +  KQ F
Sbjct: 300 LYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329


>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
           sapiens]
          Length = 675

 Score =  107 bits (267), Expect = 1e-23
 Identities = 79/292 (27%), Positives = 126/292 (43%), Gaps = 14/292 (4%)

Query: 4   QAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPK 63
           Q    A  F  G +A A+  TAV PI+ VK  +Q Q ++     +  YK   DC  ++ +
Sbjct: 324 QVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLR 383

Query: 64  EQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAA 123
            +G    +RG L  ++   P +A+     D  +  F+     H       A  + +GG A
Sbjct: 384 YEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFM-----HKDGSVPLAAEILAGGCA 438

Query: 124 GATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQG 183
           G + + F  PL+  + RL    G+  T      L      + +  G  G+Y+G       
Sbjct: 439 GGSQVIFTNPLEIVKIRLQV-AGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLR 492

Query: 184 IIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAV-AGVVSYPFDTVRRRMMMQS 242
            I + A YF  Y   K    +        S ++A  +  + A  +  P D ++ R  +Q 
Sbjct: 493 DIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTR--LQV 550

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEL 294
             +     Y+G +DC+RKI R+EG KA +KGA + V R      V +L  EL
Sbjct: 551 AARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 602


>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
           sapiens]
          Length = 676

 Score =  107 bits (267), Expect = 1e-23
 Identities = 79/292 (27%), Positives = 126/292 (43%), Gaps = 14/292 (4%)

Query: 4   QAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPK 63
           Q    A  F  G +A A+  TAV PI+ VK  +Q Q ++     +  YK   DC  ++ +
Sbjct: 325 QVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLR 384

Query: 64  EQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAA 123
            +G    +RG L  ++   P +A+     D  +  F+     H       A  + +GG A
Sbjct: 385 YEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFM-----HKDGSVPLAAEILAGGCA 439

Query: 124 GATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQG 183
           G + + F  PL+  + RL    G+  T      L      + +  G  G+Y+G       
Sbjct: 440 GGSQVIFTNPLEIVKIRLQV-AGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLR 493

Query: 184 IIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAV-AGVVSYPFDTVRRRMMMQS 242
            I + A YF  Y   K    +        S ++A  +  + A  +  P D ++ R  +Q 
Sbjct: 494 DIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTR--LQV 551

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEL 294
             +     Y+G +DC+RKI R+EG KA +KGA + V R      V +L  EL
Sbjct: 552 AARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 603


>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
          Length = 370

 Score =  106 bits (264), Expect = 3e-23
 Identities = 82/297 (27%), Positives = 143/297 (48%), Gaps = 30/297 (10%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           K  L+G +A A+S+T  AP++R K+ +QV ++SK       +  ++  +  + +E G  S
Sbjct: 94  KFLLSGAMAGAVSRTGTAPLDRAKVYMQV-YSSKT-----NFTNLLGGLQSMVQEGGFRS 147

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            WRGN  NV++  P  A+ F+  ++ K  F G      Q    F   L +G  A A S  
Sbjct: 148 LWRGNGINVLKIAPEYAIKFSVFEQCKNYFCG-----IQGSPPFQERLLAGSLAVAISQT 202

Query: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189
            + P++  +TRL   + ++G   +++GL DC  +I + +G R LY+G+  ++ GII Y  
Sbjct: 203 LINPMEVLKTRLT--LRRTG---QYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYAC 257

Query: 190 AYFGVYDTAKGM-------LPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242
               VY+  +         + DP     +VS       T    + SYP   VR RM  Q 
Sbjct: 258 TDLAVYEMLQCFWVKSGRDMGDPSG---LVSLSSVTLSTTCGQMASYPLTLVRTRMQAQD 314

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGM-GGAFVLVLYDELKKVI 298
             +G++    G +   ++I   +G    ++G    +L+ +  G    V+Y+ +KK +
Sbjct: 315 TVEGSNPTMRGVL---QRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKTL 368



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 55/206 (26%), Positives = 90/206 (43%), Gaps = 34/206 (16%)

Query: 8   FAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGV 67
           F +  LAG +A AIS+T + P+E +K  L ++          QYKG++DC  +I + +G 
Sbjct: 186 FQERLLAGSLAVAISQTLINPMEVLKTRLTLRRTG-------QYKGLLDCARQILQREGT 238

Query: 68  LSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATS 127
            + +RG L N++   P    + A  +  +            FW     ++  G  +G  S
Sbjct: 239 RALYRGYLPNMLGIIPYACTDLAVYEMLQ-----------CFWVKSGRDM--GDPSGLVS 285

Query: 128 LCFV-----------YPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQG 176
           L  V           YPL   RTR+ A     G+    RG+   L +I    G  GLY+G
Sbjct: 286 LSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPTMRGV---LQRILAQQGWLGLYRG 342

Query: 177 FSVSVQGIIIYRAAYFGVYDTAKGML 202
            + ++  ++      + VY+  K  L
Sbjct: 343 MTPTLLKVLPAGGISYVVYEAMKKTL 368


>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
           sapiens]
          Length = 325

 Score =  106 bits (264), Expect = 3e-23
 Identities = 85/296 (28%), Positives = 135/296 (45%), Gaps = 22/296 (7%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK-QYKGIVDCIVRIPKEQGVL 68
           K F+ GG+A+ +++    P++  K  LQVQ  S      + +Y+G+   + RI KE+GVL
Sbjct: 42  KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 101

Query: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
           + + G    ++R      +        K++F+  ++  T        N+  G  +G  S 
Sbjct: 102 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI-----NMICGVVSGVISS 156

Query: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
               P D  + R+ A     G+  +   +G   + I + +G RGL++G   + Q   I  
Sbjct: 157 TIANPTDVLKIRMQAQ----GSLFQGSMIGS-FIDIYQQEGTRGLWRGVVPTAQRAAIVV 211

Query: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242
                VYD  K      GM+ D   TH V S+    T      + S P D VR RMM Q 
Sbjct: 212 GVELPVYDITKKHLILSGMMGDTILTHFVSSF----TCGLAGALASNPVDVVRTRMMNQR 267

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKV 297
              G   +Y GTVD   K+++ EG  A +KG W N LR G       + Y++LK++
Sbjct: 268 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 323


>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
           sapiens]
          Length = 322

 Score =  106 bits (264), Expect = 3e-23
 Identities = 85/296 (28%), Positives = 135/296 (45%), Gaps = 22/296 (7%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK-QYKGIVDCIVRIPKEQGVL 68
           K F+ GG+A+ +++    P++  K  LQVQ  S      + +Y+G+   + RI KE+GVL
Sbjct: 39  KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98

Query: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
           + + G    ++R      +        K++F+  ++  T        N+  G  +G  S 
Sbjct: 99  ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI-----NMICGVVSGVISS 153

Query: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
               P D  + R+ A     G+  +   +G   + I + +G RGL++G   + Q   I  
Sbjct: 154 TIANPTDVLKIRMQAQ----GSLFQGSMIGS-FIDIYQQEGTRGLWRGVVPTAQRAAIVV 208

Query: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242
                VYD  K      GM+ D   TH V S+    T      + S P D VR RMM Q 
Sbjct: 209 GVELPVYDITKKHLILSGMMGDTILTHFVSSF----TCGLAGALASNPVDVVRTRMMNQR 264

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKV 297
              G   +Y GTVD   K+++ EG  A +KG W N LR G       + Y++LK++
Sbjct: 265 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320


>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
          Length = 291

 Score =  105 bits (263), Expect = 4e-23
 Identities = 85/297 (28%), Positives = 139/297 (46%), Gaps = 23/297 (7%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK-QYKGIVDCIVRIPKEQGVL 68
           K F+ GG+A+  ++    PI+  K  LQ+Q  +      + +Y+G++  +VRI +E+G+ 
Sbjct: 7   KPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLK 66

Query: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
           + + G    ++R      +        K++F+   +  T        N+  G  +G  S 
Sbjct: 67  ALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDET-----LPINVICGILSGVISS 121

Query: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
               P D  + R+ A   +S T +   G+    + I + +G RGL++G S++ Q   I  
Sbjct: 122 TIANPTDVLKIRMQA---QSNTIQG--GMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVV 176

Query: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242
                VYD  K      G++ D   TH + S+    T      + S P D VR RMM Q 
Sbjct: 177 GVELPVYDITKKHLILSGLMGDTVYTHFLSSF----TCGLAGALASNPVDVVRTRMMNQR 232

Query: 243 G-RKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKV 297
             R G    YTGT+DC  + +++EG  A +KG W N LR G       V Y++LKK+
Sbjct: 233 VLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKL 289



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 19/85 (22%), Positives = 41/85 (48%), Gaps = 4/85 (4%)

Query: 16  GIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNL 75
           G+A A++     P++ V+  +  Q   +       Y G +DC+++  K +G  + ++G  
Sbjct: 211 GLAGALASN---PVDVVRTRMMNQRVLRD-GRCSGYTGTLDCLLQTWKNEGFFALYKGFW 266

Query: 76  ANVIRYFPTQALNFAFKDKYKQIFL 100
            N +R  P   + F   ++ K++ L
Sbjct: 267 PNWLRLGPWNIIFFVTYEQLKKLDL 291


>gi|21687151 mitochondrial solute carrier protein [Homo sapiens]
          Length = 341

 Score =  104 bits (259), Expect = 1e-22
 Identities = 77/277 (27%), Positives = 131/277 (47%), Gaps = 27/277 (9%)

Query: 13  LAGGIAAAISKTAVAPIERVKLLLQVQ----HASKQIAADKQYKGIVDCIVRIPKEQGVL 68
           L  G+A  +S +  AP+E   +L QV     HA    A             R+ + +G+ 
Sbjct: 17  LCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGH----------RVWRAEGLR 66

Query: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
           + W+GN    +R FP  A+  A   K+  +F   +   +Q+    AG+L     AG  S 
Sbjct: 67  ALWKGNAVACLRLFPCSAVQLAAYRKFVVLFTDDLGHISQWSSIMAGSL-----AGMVST 121

Query: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
              YP D  +TRL   + ++  E  +RGL      I + +G   LY+G S++V G + + 
Sbjct: 122 IVTYPTDLIKTRL---IMQNILEPSYRGLLHAFSTIYQQEGFLALYRGVSLTVVGALPFS 178

Query: 189 AAYFGVYDTAKGMLPDPKNT-HIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS----G 243
           A    VY   + +   P++   +  ++       AV   +S+PF+TV+R+M  QS     
Sbjct: 179 AGSLLVYMNLEKIWNGPRDQFSLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQSPYLPH 238

Query: 244 RKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR 280
             G D+ ++G VDC+R+I + +G    + G  +N+L+
Sbjct: 239 SGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLK 275



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 44/198 (22%), Positives = 85/198 (42%), Gaps = 14/198 (7%)

Query: 6   ISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQ 65
           IS     +AG +A  +S     P + +K  L +Q+       +  Y+G++     I +++
Sbjct: 104 ISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNI-----LEPSYRGLLHAFSTIYQQE 158

Query: 66  GVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGA 125
           G L+ +RG    V+   P  A +       ++I+ G  D+ +        N A+   A A
Sbjct: 159 GFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQFS-----LPQNFANVCLAAA 213

Query: 126 TSLCFVYPLDFARTRLAADVG----KSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSV 181
            +    +P +  + ++ A         G +  F G  DC  +I K+ G+ GL+ G + ++
Sbjct: 214 VTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANL 273

Query: 182 QGIIIYRAAYFGVYDTAK 199
             I+ Y    F  ++  K
Sbjct: 274 LKIVPYFGIMFSTFEFCK 291



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 32/96 (33%), Positives = 49/96 (51%), Gaps = 2/96 (2%)

Query: 7   SFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQ--HASKQIAADKQYKGIVDCIVRIPKE 64
           S  ++F    +AAA+++T   P E VK  +Q Q  +       D  + G VDC  +I K 
Sbjct: 200 SLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKA 259

Query: 65  QGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFL 100
           QGVL  W G  AN+++  P   + F+  +  K+I L
Sbjct: 260 QGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRICL 295


>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
          Length = 312

 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 80/303 (26%), Positives = 134/303 (44%), Gaps = 24/303 (7%)

Query: 7   SFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK--QYKGIVDCIVRIPKE 64
           + A  FL  G AA  +     P++  K+ LQ+Q  ++ +   +  QY+G++  I+ + + 
Sbjct: 12  TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRT 71

Query: 65  QGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG-GVDKHTQFWRYFAGNLASGGAA 123
           +G  S + G +A + R     ++     D  KQ++   G D  +   R  AG        
Sbjct: 72  EGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC-----TT 126

Query: 124 GATSLCFVYPLDFARTRLAADV--GKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSV 181
           GA ++    P D  + R  A +  G S ++R++ G  D    I + +G+RGL++G   ++
Sbjct: 127 GAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186

Query: 182 QGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTA-----VAGVVSYPFDTVRR 236
               I   A    YD  K  L D    H++        V+A      A VV+ P D V+ 
Sbjct: 187 MRNAIVNCAEVVTYDILKEKLLD---YHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKT 243

Query: 237 RMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELK 295
           R M           Y   +DC  K+   EG  AF+KG   + LR G     + V Y++LK
Sbjct: 244 RYM-----NSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLK 298

Query: 296 KVI 298
           + +
Sbjct: 299 RAL 301



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 26/103 (25%), Positives = 48/103 (46%), Gaps = 5/103 (4%)

Query: 200 GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGAD----IMYTGTV 255
           G+ P      + V ++ A T    A +V++P DT + R+ +Q   +       + Y G +
Sbjct: 3   GLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVL 62

Query: 256 DCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLV-LYDELKKV 297
                + R EG  + + G  + + R M  A + + LYD +K+V
Sbjct: 63  GTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQV 105


>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
          Length = 315

 Score = 98.2 bits (243), Expect = 8e-21
 Identities = 82/281 (29%), Positives = 130/281 (46%), Gaps = 26/281 (9%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           ++ +AG     +S  A+ P++ VK+   V   S  +    +Y GI+ C+  I K  G+  
Sbjct: 24  ENLIAGVSGGVLSNLALHPLDLVKIRFAV---SDGLELRPKYNGILHCLTTIWKLDGLRG 80

Query: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
            ++G   N+     +  L F F +  K     G  +  +   Y    L S   AGA +LC
Sbjct: 81  LYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEY----LVSAAEAGAMTLC 136

Query: 130 FVYPLDFARTRLAA--DVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIY 187
              PL   +TRL    D   +   R+++G+ D LVKI K +G+RGLY+GF   + G   +
Sbjct: 137 ITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFG-TSH 195

Query: 188 RAAYFGVYDTAK-------GMLPDPK-NTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMM 239
            A  F  Y+  K         LP+ + +T   +S      + AVA   +YP+  VR R+ 
Sbjct: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA--ATYPYQVVRARLQ 253

Query: 240 MQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR 280
            Q       + Y+G +D   K +R EG   F+KG   N++R
Sbjct: 254 DQ------HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIR 288



 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 49/184 (26%), Positives = 80/184 (43%), Gaps = 5/184 (2%)

Query: 116 NLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQ 175
           NL +G + G  S   ++PLD  + R A   G      ++ G+  CL  I K DG+RGLYQ
Sbjct: 25  NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLE-LRPKYNGILHCLTTIWKLDGLRGLYQ 83

Query: 176 GFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGV--VSYPFDT 233
           G + ++ G  +    YF  Y+  K    + +   +  +  +     A A    ++ P   
Sbjct: 84  GVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWV 143

Query: 234 VRRRMMMQSGR--KGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLY 291
            + R+M+Q           Y G  D   KI++ EG +  +KG    +     GA   + Y
Sbjct: 144 TKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAY 203

Query: 292 DELK 295
           + LK
Sbjct: 204 ELLK 207



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 11/189 (5%)

Query: 18  AAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLAN 77
           A A++     P+   K  L +Q+ +   +  +QYKG+ D +V+I K +GV   ++G +  
Sbjct: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG 189

Query: 78  VIRYFPTQ--ALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLD 135
           +   F T   AL F   +  K  +   +++  +        ++    +   ++   YP  
Sbjct: 190 L---FGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQ 246

Query: 136 FARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVY 195
             R RL            + G+ D + K  + +G+ G Y+G + ++  +       F VY
Sbjct: 247 VVRARL------QDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300

Query: 196 DTAKGMLPD 204
           +     L D
Sbjct: 301 ENVSHFLLD 309


>gi|13899342 solute carrier [Homo sapiens]
          Length = 315

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 75/306 (24%), Positives = 132/306 (43%), Gaps = 44/306 (14%)

Query: 1   MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR 60
           MT Q +S     + GG+A  +  T V PI+  K  LQ QH          YKG++DC+++
Sbjct: 1   MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAM------YKGMIDCLMK 54

Query: 61  IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFL-GGVDKHTQFWRYFAGNLAS 119
             + +G    +RG   N+    P +A+  A  D ++++ +  G+ ++ +        + +
Sbjct: 55  TARAEGFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKM------EMLA 108

Query: 120 GGAAGATSLCFVYPLDFARTRLAADVGK-------------------SGTEREFRGLGDC 160
           G  AG   +    P++  + +L  D G+                   +G+    R     
Sbjct: 109 GCGAGMCQVVVTCPMEMLKIQL-QDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSAT 167

Query: 161 LV--KITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKG-----MLPDPKNTHIVVS 213
           L+  ++ ++ G+ GLY+G   ++   I +   YF ++          +       H  VS
Sbjct: 168 LIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVS 227

Query: 214 WMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKG 273
             +A ++ AVA     P D ++ R+       G D MY+G  DC RK++  EG  AF KG
Sbjct: 228 GCVAGSIAAVAVT---PLDVLKTRIQTLKKGLGED-MYSGITDCARKLWIQEGPSAFMKG 283

Query: 274 AWSNVL 279
           A    L
Sbjct: 284 AGCRAL 289


>gi|13259541 uncoupling protein 2 [Homo sapiens]
          Length = 309

 Score = 94.7 bits (234), Expect = 8e-20
 Identities = 74/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%)

Query: 12  FLAGGIAAAISKTAVAPIERVKLLLQVQHASK---QIAADKQYKGIVDCIVRIPKEQGVL 68
           FL  G AA I+     P++  K+ LQ+Q  S+   +  A  QY+G++  I+ + + +G  
Sbjct: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76

Query: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
           S + G +A + R     ++     D  KQ +  G +  +         L +G   GA ++
Sbjct: 77  SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAV 131

Query: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
               P D  + R  A   ++G  R ++   +    I + +G RGL++G S +V    I  
Sbjct: 132 AVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVN 190

Query: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242
            A    YD  K       ++ D    H   ++      T +A     P D V+ R M   
Sbjct: 191 CAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS----PVDVVKTRYM--- 243

Query: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKVI 298
               A   Y+    C   + + EG +AF+KG   + LR G     + V Y++LK+ +
Sbjct: 244 --NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)

Query: 212 VSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKG-----ADIMYTGTVDCWRKIFRDEG 266
           V ++ A T   +A ++++P DT + R+ +Q   +G     A   Y G +     + R EG
Sbjct: 15  VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74

Query: 267 GKAFFKGAWSNVLRGMGGAFVLV-LYDELKK 296
            ++ + G  + + R M  A V + LYD +K+
Sbjct: 75  PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQ 105


>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
          Length = 303

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 80/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 9   AKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVL 68
           A DFLAG            P + VK+ LQVQ   K      QY+G + C   I K++ VL
Sbjct: 2   ALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKP-----QYRGTLHCFKSIIKQESVL 56

Query: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
             ++G  + ++      AL F  +    +  LG      QF         +G AAGA   
Sbjct: 57  GLYKGLGSPLMGLTFINALVFGVQGNTLRA-LGHDSPLNQF--------LAGAAAGAIQC 107

Query: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
               P++ A+TRL   +  +G  R ++G  DCL +I   +G+RG+ +G   ++       
Sbjct: 108 VICCPMELAKTRL--QLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSF 165

Query: 189 AAYFGVYDTAKGMLP-DPKNTHIVVSWMIAQTVTAVAGVVS-YPFDTVRRRMMMQSGRKG 246
             YF  YD     L  +P +  +V   ++A   + +   +S YP D V+ R+    G +G
Sbjct: 166 GVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQAD-GLRG 224

Query: 247 ADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR 280
           A   Y G +DC  + +R EG + F +G  S +LR
Sbjct: 225 AP-RYRGILDCVHQSYRAEGWRVFTRGLASTLLR 257



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 53/181 (29%), Positives = 86/181 (47%), Gaps = 10/181 (5%)

Query: 12  FLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFW 71
           FLAG  A AI      P+E  K  LQ+Q A       + YKG +DC+ +I   +G+    
Sbjct: 96  FLAGAAAGAIQCVICCPMELAKTRLQLQDAGPA----RTYKGSLDCLAQIYGHEGLRGVN 151

Query: 72  RGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFV 131
           RG ++ ++R  P+  + F   D   +    G +   +        L +GG +G  S    
Sbjct: 152 RGMVSTLLRETPSFGVYFLTYDALTRAL--GCEPGDRL--LVPKLLLAGGTSGIVSWLST 207

Query: 132 YPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAY 191
           YP+D  ++RL AD G  G  R +RG+ DC+ +  +++G R   +G + ++       AA 
Sbjct: 208 YPVDVVKSRLQAD-GLRGAPR-YRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAAT 265

Query: 192 F 192
           F
Sbjct: 266 F 266



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 48/183 (26%), Positives = 81/183 (44%), Gaps = 13/183 (7%)

Query: 119 SGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFS 178
           +G A G   +   +P D  + RL     +S  + ++RG   C   I K + + GLY+G  
Sbjct: 7   AGCAGGVAGVLVGHPFDTVKVRLQV---QSVEKPQYRGTLHCFKSIIKQESVLGLYKGLG 63

Query: 179 VSVQGIIIYRAAYFGVY-DTAKGMLPD-PKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRR 236
             + G+    A  FGV  +T + +  D P N      ++      A+  V+  P +  + 
Sbjct: 64  SPLMGLTFINALVFGVQGNTLRALGHDSPLN-----QFLAGAAAGAIQCVICCPMELAKT 118

Query: 237 RMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVL-YDELK 295
           R+ +Q    G    Y G++DC  +I+  EG +   +G  S +LR      V  L YD L 
Sbjct: 119 RLQLQDA--GPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALT 176

Query: 296 KVI 298
           + +
Sbjct: 177 RAL 179



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 4/81 (4%)

Query: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
           K  LAGG +  +S  +  P++ VK  LQ       +    +Y+GI+DC+ +  + +G   
Sbjct: 191 KLLLAGGTSGIVSWLSTYPVDVVKSRLQADG----LRGAPRYRGILDCVHQSYRAEGWRV 246

Query: 70  FWRGNLANVIRYFPTQALNFA 90
           F RG  + ++R FP  A  FA
Sbjct: 247 FTRGLASTLLRAFPVNAATFA 267


>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
          Length = 323

 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 74/303 (24%), Positives = 131/303 (43%), Gaps = 19/303 (6%)

Query: 9   AKDFLAGGIAAAISKTAVAPIERVKLLLQVQ------HASKQIAADKQYKGIVDCIVRIP 62
           A  FL  G AA +++ A  P++  K  LQ+Q                 Y+G+V   + I 
Sbjct: 20  ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79

Query: 63  KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG-GVDKHTQFWRYFAGNLASGG 121
           +E+G L  W+G    + R+           +  +++  G   D+H   W+   G    G 
Sbjct: 80  EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIG----GM 135

Query: 122 AAGATSLCFVYPLDFARTRLAADVGK---SGTEREFRGLGDCLVKITKSDGIRGLYQGFS 178
            AG        P D  + ++  + GK    G    FRG+     KI    GIRGL+ G+ 
Sbjct: 136 MAGVIGQFLANPTDLVKVQMQME-GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWV 194

Query: 179 VSVQGIIIYRAAYFGVYDTAKG--MLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRR 236
            ++Q   +        YDT K   +L  P   +I+   + +     VA ++  P D ++ 
Sbjct: 195 PNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKS 254

Query: 237 RMMMQ-SGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVL-YDEL 294
           R+M Q   ++G  ++Y  + DC  +  + EG  + +KG   + LR    + V  L Y+++
Sbjct: 255 RIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKI 314

Query: 295 KKV 297
           +++
Sbjct: 315 REM 317


>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
          Length = 275

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 73/277 (26%), Positives = 121/277 (43%), Gaps = 23/277 (8%)

Query: 7   SFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK--QYKGIVDCIVRIPKE 64
           + A  FL  G AA  +     P++  K+ LQ+Q  ++ +   +  QY+G++  I+ + + 
Sbjct: 12  TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRT 71

Query: 65  QGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG-GVDKHTQFWRYFAGNLASGGAA 123
           +G  S + G +A + R     ++     D  KQ++   G D  +   R  AG        
Sbjct: 72  EGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC-----TT 126

Query: 124 GATSLCFVYPLDFARTRLAADV--GKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSV 181
           GA ++    P D  + R  A +  G S ++R++ G  D    I + +G+RGL++G   ++
Sbjct: 127 GAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186

Query: 182 QGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTA-----VAGVVSYPFDTVRR 236
               I   A    YD  K  L D    H++        V+A      A VV+ P D V+ 
Sbjct: 187 MRNAIVNCAEVVTYDILKEKLLD---YHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKT 243

Query: 237 RMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKG 273
           R M           Y   +DC  K+   EG  AF+KG
Sbjct: 244 RYM-----NSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 49/185 (26%), Positives = 88/185 (47%), Gaps = 15/185 (8%)

Query: 126 TSLCFV----YPLDFARTRLAADVGKSGTER----EFRGLGDCLVKITKSDGIRGLYQGF 177
           T+ CF     +PLD A+ RL         +     ++RG+   ++ + +++G    Y G 
Sbjct: 22  TAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL 81

Query: 178 SVSVQGIIIYRAAYFGVYDTAKGMLPDPK---NTHIVVSWMIAQTVTAVAGVVSYPFDTV 234
              +Q  + + +   G+YD+ K +   PK   N+ +    +   T  A+A   + P D V
Sbjct: 82  VAGLQRQMSFASIRIGLYDSVKQVYT-PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140

Query: 235 RRRMM--MQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLY 291
           + R    +  G   +D  Y+GT+D +R I R+EG +  +KG   N++R  +     +V Y
Sbjct: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200

Query: 292 DELKK 296
           D LK+
Sbjct: 201 DILKE 205



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 26/103 (25%), Positives = 48/103 (46%), Gaps = 5/103 (4%)

Query: 200 GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGAD----IMYTGTV 255
           G+ P      + V ++ A T    A +V++P DT + R+ +Q   +       + Y G +
Sbjct: 3   GLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVL 62

Query: 256 DCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLV-LYDELKKV 297
                + R EG  + + G  + + R M  A + + LYD +K+V
Sbjct: 63  GTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQV 105


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,933,705
Number of Sequences: 37866
Number of extensions: 388439
Number of successful extensions: 1461
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 917
Number of HSP's gapped (non-prelim): 179
length of query: 298
length of database: 18,247,518
effective HSP length: 102
effective length of query: 196
effective length of database: 14,385,186
effective search space: 2819496456
effective search space used: 2819496456
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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