Search of human proteins with 155969707

Search of human proteins with 155969707

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|155969707 insulin-degrading enzyme [Homo sapiens]
         (1019 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|155969707 insulin-degrading enzyme [Homo sapiens]                 2077   0.0  
gi|156071450 nardilysin isoform a [Homo sapiens]                      544   e-154
gi|156071452 nardilysin isoform b [Homo sapiens]                      541   e-154
gi|94538354 mitochondrial processing peptidase beta subunit prec...    44   8e-04
gi|46593007 ubiquinol-cytochrome c reductase core protein I [Hom...    43   0.001
gi|24308013 peptidase (mitochondrial processing) alpha [Homo sap...    40   0.015
gi|41352061 metalloprotease 1 [Homo sapiens]                           38   0.056
gi|31543980 zinc finger protein 263 [Homo sapiens]                     32   4.0  
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]             31   5.2  
gi|23308722 TTK protein kinase [Homo sapiens]                          30   8.9  
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              30   8.9  
gi|10863949 angiopoietin-like 7 [Homo sapiens]                         30   8.9  

>gi|155969707 insulin-degrading enzyme [Homo sapiens]
          Length = 1019

 Score = 2077 bits (5381), Expect = 0.0
 Identities = 1019/1019 (100%), Positives = 1019/1019 (100%)

Query: 1    MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
            MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1    MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60

Query: 61   KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
            KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61   KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120

Query: 121  YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
            YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121  YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180

Query: 181  REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
            REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181  REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240

Query: 241  LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
            LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241  LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300

Query: 301  LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
            LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301  LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360

Query: 361  GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
            GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361  GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420

Query: 421  AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
            AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421  AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480

Query: 481  VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
            VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481  VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540

Query: 541  EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
            EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541  EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600

Query: 601  KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
            KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601  KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660

Query: 661  IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
            IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661  IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720

Query: 721  SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
            SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721  SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780

Query: 781  QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
            QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781  QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840

Query: 841  NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
            NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841  NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900

Query: 901  SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
            SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901  SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960

Query: 961  REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
            REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961  REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019


>gi|156071450 nardilysin isoform a [Homo sapiens]
          Length = 1219

 Score =  544 bits (1401), Expect = e-154
 Identities = 316/936 (33%), Positives = 507/936 (54%), Gaps = 20/936 (2%)

Query: 36   KKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIG 95
            K TYSKM++  +    N       + R      LA         +  T  S+AAL V +G
Sbjct: 229  KSTYSKMSSTLLVETRNLYGVVGAESRSAPVQHLAGWQAEEQQGETDTVLSAAALCVGVG 288

Query: 96   SLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSH 155
            S +DP ++ GL+HF EHM+F+G+ KYP EN +  FL +H GS NA T  E T + FDV  
Sbjct: 289  SFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQR 348

Query: 156  EHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPF 215
            ++ + ALDR+AQFF+ PL      DREV AVDSE++    +DA R   L  +   P HP 
Sbjct: 349  KYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPM 408

Query: 216  SKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLF 275
             KF  GN  TL+  P +  ID    L +F   YYSS+ M + V  +E+LD L   V ++F
Sbjct: 409  GKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIF 468

Query: 276  SEVENKNVPLPEFPE--HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
            S++ N  +P P F     PF      +LY++VPI+ I  L +T+ +P  Q++Y+  P HY
Sbjct: 469  SQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHY 528

Query: 334  LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA----RGFMFFIINVDLTEEGLLHVED 389
            +  L+GHEG GS+LS L+ K W   L GG  E        +  F I++ LT+EG  H  +
Sbjct: 529  ISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYE 588

Query: 390  IILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEV 449
            +   +FQY++ L+  GP++ +F+E + +    F ++++  P  Y   +   +  YPL+++
Sbjct: 589  VAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDI 648

Query: 450  LTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEV 509
            LT + LL E++P++I   L++L P+   + ++S + EGK D  E+W+GTQY  E I +  
Sbjct: 649  LTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSW 708

Query: 510  IKKW-QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFF 568
             + W  N +LN    LP +N++I T+F +   +   T YP  I +T    LW+K+D+KF 
Sbjct: 709  AELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFK 768

Query: 569  LPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMY 628
            +PKA + F   SP       +  +  +++ +L  +L E AY A++A L Y L    +G+ 
Sbjct: 769  IPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLI 828

Query: 629  LSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRL 688
            + VKG+N K P+L + II+ +A F      F +I E   ++  N    +P   A     L
Sbjct: 829  IRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILI-KPETLAKDVRLL 887

Query: 689  LMTEVAWTK-DELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVED 747
            ++    W+  D+ +  +D ++L  L +F+ +  S+L +E L+ GN+T   ++  ++ V D
Sbjct: 888  ILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVD 947

Query: 748  TLIEHAHTKPLLPSQLVRYREVQLPDRGWFV-YQQRNEVHNNCGIEIYYQTDMQSTSENM 806
             L    + KPL     V+++ V+LP        +  N+   N  + +YYQ+  +S  E  
Sbjct: 948  KL----NFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYT 1003

Query: 807  FLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPH---YLESRV 863
             +EL    + EPCF+ LRTK+ LGY V+   R  +GI G    + ++   +    ++ ++
Sbjct: 1004 LMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKI 1063

Query: 864  EAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNT 923
            E FL + E+ IE++TEEAF   + AL   +  +   L  E  + W E+++QQY FDR   
Sbjct: 1064 EEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAH 1123

Query: 924  EVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVL 959
            E+  LK+ +K D++ ++K   A   P    +SVHV+
Sbjct: 1124 EIEALKSFSKSDLVNWFK---AHRGPGSKMLSVHVV 1156



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 15/27 (55%), Positives = 21/27 (77%)

Query: 54  ITKSPEDKREYRGLELANGIKVLLISD 80
           I KSP D ++YR ++L NG++ LLISD
Sbjct: 103 IVKSPSDPKQYRYIKLQNGLQALLISD 129


>gi|156071452 nardilysin isoform b [Homo sapiens]
          Length = 1151

 Score =  541 bits (1395), Expect = e-154
 Identities = 308/891 (34%), Positives = 495/891 (55%), Gaps = 21/891 (2%)

Query: 82   TTDK-SSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNA 140
            TT+K S+AAL V +GS +DP ++ GL+HF EHM+F+G+ KYP EN +  FL +H GS NA
Sbjct: 206  TTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNA 265

Query: 141  FTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWR 200
             T  E T + FDV  ++ + ALDR+AQFF+ PL      DREV AVDSE++    +DA R
Sbjct: 266  STDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANR 325

Query: 201  LFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLG 260
               L  +   P HP  KF  GN  TL+  P +  ID    L +F   YYSS+ M + V  
Sbjct: 326  KEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQS 385

Query: 261  RESLDDLTNLVVKLFSEVENKNVPLPEFPE--HPFQEEHLKQLYKIVPIKDIRNLYVTFP 318
            +E+LD L   V ++FS++ N  +P P F     PF      +LY++VPI+ I  L +T+ 
Sbjct: 386  KETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWA 445

Query: 319  IPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA----RGFMFFI 374
            +P  Q++Y+  P HY+  L+GHEG GS+LS L+ K W   L GG  E        +  F 
Sbjct: 446  LPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFS 505

Query: 375  INVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYT 434
            I++ LT+EG  H  ++   +FQY++ L+  GP++ +F+E + +    F ++++  P  Y 
Sbjct: 506  ISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYV 565

Query: 435  SKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEE 494
              +   +  YPL+++LT + LL E++P++I   L++L P+   + ++S + EGK D  E+
Sbjct: 566  ENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEK 625

Query: 495  WYGTQYKQEAIPDEVIKKW-QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKD 553
            W+GTQY  E I +   + W  N +LN    LP +N++I T+F +   +   T YP  I +
Sbjct: 626  WFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVN 685

Query: 554  TAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAEL 613
            T    LW+K+D+KF +PKA + F   SP       +  +  +++ +L  +L E AY A++
Sbjct: 686  TPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADV 745

Query: 614  AGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNF 673
            A L Y L    +G+ + VKG+N K P+L + II+ +A F      F +I E   ++  N 
Sbjct: 746  AQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNI 805

Query: 674  RAEQPHQHAMYYLRLLMTEVAWTK-DELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGN 732
               +P   A     L++    W+  D+ +  +D ++L  L +F+ +  S+L +E L+ GN
Sbjct: 806  LI-KPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGN 864

Query: 733  ITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFV-YQQRNEVHNNCGI 791
            +T   ++  ++ V D L    + KPL     V+++ V+LP        +  N+   N  +
Sbjct: 865  VTSTESMDFLKYVVDKL----NFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEV 920

Query: 792  EIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQ 851
             +YYQ+  +S  E   +EL    + EPCF+ LRTK+ LGY V+   R  +GI G    + 
Sbjct: 921  TVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVG 980

Query: 852  SEKPPH---YLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYW 908
            ++   +    ++ ++E FL + E+ IE++TEEAF   + AL   +  +   L  E  + W
Sbjct: 981  TQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNW 1040

Query: 909  GEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVL 959
             E+++QQY FDR   E+  LK+ +K D++ ++K   A   P    +SVHV+
Sbjct: 1041 NEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFK---AHRGPGSKMLSVHVV 1088



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 15/27 (55%), Positives = 21/27 (77%)

Query: 54  ITKSPEDKREYRGLELANGIKVLLISD 80
           I KSP D ++YR ++L NG++ LLISD
Sbjct: 103 IVKSPSDPKQYRYIKLQNGLQALLISD 129


>gi|94538354 mitochondrial processing peptidase beta subunit
           precursor [Homo sapiens]
          Length = 489

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 46/202 (22%), Positives = 80/202 (39%), Gaps = 9/202 (4%)

Query: 69  LANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYS 128
           L +G++V    D      +  L +  GS  +     G +HF EHM F GTKK   + +  
Sbjct: 63  LESGLRVAS-EDSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKK-RSQLDLE 120

Query: 129 QFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDS 188
             +       NA+TS E T YY     + L  A++  A         E+  +RE   +  
Sbjct: 121 LEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILR 180

Query: 189 EHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAY 248
           E ++   N    +F    AT        +   G    +++         R++L+ + + +
Sbjct: 181 EMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSIS-------RKDLVDYITTH 233

Query: 249 YSSNLMAVCVLGRESLDDLTNL 270
           Y    + +   G  S D+L +L
Sbjct: 234 YKGPRIVLAAAGGVSHDELLDL 255


>gi|46593007 ubiquinol-cytochrome c reductase core protein I [Homo
           sapiens]
          Length = 480

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 45/207 (21%), Positives = 83/207 (40%), Gaps = 13/207 (6%)

Query: 69  LANGIKVLL--ISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENE 126
           L NG++V     S PT    +  + + +GS  +     G  +F EH+ F GTK  P  + 
Sbjct: 53  LDNGLRVASEQSSQPTC---TVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRP-GSA 108

Query: 127 YSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAV 186
             + +       NA+++ EHT YY     + L  A++           ++S  ++E + +
Sbjct: 109 LEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLGDIVQNCSLEDSQIEKERDVI 168

Query: 187 DSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHS 246
             E ++N  +    +F    AT     P ++   G    +           R +L ++ S
Sbjct: 169 LREMQENDASMRDVVFNYLHATAFQGTPLAQAVEGPSENVRKLS-------RADLTEYLS 221

Query: 247 AYYSSNLMAVCVLGRESLDDLTNLVVK 273
            +Y +  M +   G      L +L  K
Sbjct: 222 THYKAPRMVLAAAGGVEHQQLLDLAQK 248


>gi|24308013 peptidase (mitochondrial processing) alpha [Homo
           sapiens]
          Length = 525

 Score = 39.7 bits (91), Expect = 0.015
 Identities = 30/123 (24%), Positives = 56/123 (45%), Gaps = 2/123 (1%)

Query: 55  TKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHML 114
           T   ++K E +   L NG++V    +      +  + ++ GS  +   ++G++HF E + 
Sbjct: 58  TVDGQEKFETKVTTLDNGLRVAS-QNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLA 116

Query: 115 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP-L 173
           F  T ++  ++E    L +H G  +  TS + T Y      + L+  +   A   L P L
Sbjct: 117 FSSTARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRL 176

Query: 174 FDE 176
            DE
Sbjct: 177 TDE 179


>gi|41352061 metalloprotease 1 [Homo sapiens]
          Length = 1037

 Score = 37.7 bits (86), Expect = 0.056
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 4/76 (5%)

Query: 100 PPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGS-SNAFTSGEHTNYYFDVSH-EH 157
           P +  G+ H  EH +  G++KYP  + + + L+    +  NAFT+ ++T Y F   + + 
Sbjct: 96  PMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKD 155

Query: 158 LEGALDRF--AQFFLC 171
            +  L  +  A FF C
Sbjct: 156 FQNLLSVYLDATFFPC 171


>gi|31543980 zinc finger protein 263 [Homo sapiens]
          Length = 683

 Score = 31.6 bits (70), Expect = 4.0
 Identities = 34/162 (20%), Positives = 65/162 (40%), Gaps = 18/162 (11%)

Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
           E   L    FRF++   PR   S++  + H +   E+ T E +LE     ++E  L  L 
Sbjct: 38  EASHLRFRRFRFQEAAGPREALSRLQELCHGWLRPEMRTKEQILELL---VLEQFLTIL- 93

Query: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
           P+ ++  +     E   +        Q +   +  +V    +  ++  +  LP +     
Sbjct: 94  PQEIQSRVQELHPESGEEAVTLVEDMQRELGRLRQQVTNHGRGTEVLLEEPLPLETARES 153

Query: 533 TNFEILPLEKEATPYPAL--------------IKDTAMSKLW 560
            +F++ P+E E +P P L              +K+ A+S  W
Sbjct: 154 PSFKLEPMETERSPGPRLQELLGPSPQRDPQAVKERALSAPW 195


>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
          Length = 1061

 Score = 31.2 bits (69), Expect = 5.2
 Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 14/77 (18%)

Query: 34  FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
           F K  Y K N  A+KR+              + +EL    KVL       D  +  L   
Sbjct: 553 FAKTAYYKGNLVAVKRVNR------------KRIELTR--KVLFELKHMRDVQNEHLTRF 598

Query: 94  IGSLSDPPNIAGLSHFC 110
           +G+ +DPPNI  L+ +C
Sbjct: 599 VGACTDPPNICILTEYC 615


>gi|23308722 TTK protein kinase [Homo sapiens]
          Length = 857

 Score = 30.4 bits (67), Expect = 8.9
 Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 11/103 (10%)

Query: 260 GRESLDDLTNLVVKLFSEVE-NKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIR------N 312
           G+     + N + KL + ++ N  +  P+ PE   Q+  LK   K  P + I       +
Sbjct: 730 GKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDV-LKCCLKRDPKQRISIPELLAH 788

Query: 313 LYV---TFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
            YV   T P+  + K       + LG L+G   P S+L   K+
Sbjct: 789 PYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKT 831


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 30.4 bits (67), Expect = 8.9
 Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 1/57 (1%)

Query: 77  LISDPTTDKSSAAL-DVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLS 132
           L + P  D S  AL +         PN AG  HF E++L +  KK   E++Y   ++
Sbjct: 20  LRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVVSLKKKRSEDDYEPIIT 76


>gi|10863949 angiopoietin-like 7 [Homo sapiens]
          Length = 346

 Score = 30.4 bits (67), Expect = 8.9
 Identities = 20/78 (25%), Positives = 29/78 (37%), Gaps = 3/78 (3%)

Query: 125 NEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVN 184
           N Y  FL  + G+        H N  F    +  +  LD+ AQ      +   C D  +N
Sbjct: 245 NSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLN 304

Query: 185 AVD---SEHEKNVMNDAW 199
            V     EH K++    W
Sbjct: 305 GVYYRLGEHNKHLDGITW 322


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,601,834
Number of Sequences: 37866
Number of extensions: 1815968
Number of successful extensions: 3962
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 3942
Number of HSP's gapped (non-prelim): 15
length of query: 1019
length of database: 18,247,518
effective HSP length: 112
effective length of query: 907
effective length of database: 14,006,526
effective search space: 12703919082
effective search space used: 12703919082
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.