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Search of human proteins with 153945765
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153945765 mitogen-activated protein kinase kinase kinase 1
[Homo sapiens]
(1512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 3018 0.0
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 204 4e-52
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 204 4e-52
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 199 2e-50
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 184 4e-46
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 182 2e-45
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 169 1e-41
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 164 8e-40
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 162 2e-39
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 162 2e-39
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 155 4e-37
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 145 2e-34
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 145 2e-34
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 145 2e-34
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 145 2e-34
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 145 2e-34
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 145 2e-34
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 140 7e-33
gi|41872374 polo-like kinase 3 [Homo sapiens] 139 3e-32
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 137 6e-32
gi|32483399 p21-activated kinase 2 [Homo sapiens] 137 1e-31
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 137 1e-31
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 136 1e-31
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 136 1e-31
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 136 1e-31
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 136 1e-31
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 136 1e-31
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 136 1e-31
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 135 4e-31
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 133 1e-30
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 3018 bits (7825), Expect = 0.0
Identities = 1512/1512 (100%), Positives = 1512/1512 (100%)
Query: 1 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR 60
MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR
Sbjct: 1 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR 60
Query: 61 QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG 120
QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG
Sbjct: 61 QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG 120
Query: 121 GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP 180
GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP
Sbjct: 121 GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP 180
Query: 181 EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA 240
EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA
Sbjct: 181 EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA 240
Query: 241 ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS 300
ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS
Sbjct: 241 ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS 300
Query: 301 PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF 360
PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF
Sbjct: 301 PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF 360
Query: 361 VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT 420
VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT
Sbjct: 361 VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT 420
Query: 421 LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR 480
LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR
Sbjct: 421 LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR 480
Query: 481 RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN 540
RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN
Sbjct: 481 RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN 540
Query: 541 LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG 600
LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG
Sbjct: 541 LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG 600
Query: 601 ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA 660
ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA
Sbjct: 601 ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA 660
Query: 661 MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG 720
MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG
Sbjct: 661 MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG 720
Query: 721 REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD 780
REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD
Sbjct: 721 REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD 780
Query: 781 VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM 840
VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM
Sbjct: 781 VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM 840
Query: 841 LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS 900
LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS
Sbjct: 841 LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS 900
Query: 901 SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG 960
SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG
Sbjct: 901 SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG 960
Query: 961 RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ 1020
RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ
Sbjct: 961 RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ 1020
Query: 1021 TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS 1080
TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS
Sbjct: 1021 TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS 1080
Query: 1081 MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM 1140
MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM
Sbjct: 1081 MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM 1140
Query: 1141 PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD 1200
PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD
Sbjct: 1141 PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD 1200
Query: 1201 ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA 1260
ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA
Sbjct: 1201 ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA 1260
Query: 1261 QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN 1320
QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN
Sbjct: 1261 QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN 1320
Query: 1321 LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST 1380
LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST
Sbjct: 1321 LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST 1380
Query: 1381 GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII 1440
GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
Sbjct: 1381 GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII 1440
Query: 1441 EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR 1500
EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR
Sbjct: 1441 EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR 1500
Query: 1501 ELLKHPVFRTTW 1512
ELLKHPVFRTTW
Sbjct: 1501 ELLKHPVFRTTW 1512
>gi|42794767 mitogen-activated protein kinase kinase kinase 3 isoform
1 [Homo sapiens]
Length = 657
Score = 204 bits (520), Expect = 4e-52
Identities = 118/268 (44%), Positives = 164/268 (61%), Gaps = 15/268 (5%)
Query: 1243 WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLN 1302
W +G+ +G GAF Y DV TG +A KQV + + S E + V AL EI+++ +L
Sbjct: 393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPD-SPETSKEVSALECEIQLLKNLQ 451
Query: 1303 HPNIIRMLGATCEKSNYNL--FIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYL 1360
H I++ G +++ L F+E+M GGSV L YGA ESV YT Q+L G+SYL
Sbjct: 452 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 511
Query: 1361 HENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGTIAFMA 1417
H N I+HRD+KGAN+L DS G +++ DFGA+ RL + GTG + GT +M+
Sbjct: 512 HSNMIVHRDIKGANILRDSAG-NVKLGDFGASKRLQTICMSGTG----MRSVTGTPYWMS 566
Query: 1418 PEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHL 1477
PEV+ G+ YGR DVWS+GC ++EM KPPW AE + +A IFKIA+ T P +PSH+
Sbjct: 567 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPW-AEYEA--MAAIFKIATQPTNPQLPSHI 623
Query: 1478 SPGLRDVALRCLELQPQDRPPSRELLKH 1505
S RD LR + ++ + RP + ELL H
Sbjct: 624 SEHGRDF-LRRIFVEARQRPSAEELLTH 650
>gi|42794765 mitogen-activated protein kinase kinase kinase 3 isoform
2 [Homo sapiens]
Length = 626
Score = 204 bits (520), Expect = 4e-52
Identities = 118/268 (44%), Positives = 164/268 (61%), Gaps = 15/268 (5%)
Query: 1243 WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLN 1302
W +G+ +G GAF Y DV TG +A KQV + + S E + V AL EI+++ +L
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPD-SPETSKEVSALECEIQLLKNLQ 420
Query: 1303 HPNIIRMLGATCEKSNYNL--FIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYL 1360
H I++ G +++ L F+E+M GGSV L YGA ESV YT Q+L G+SYL
Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 1361 HENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGTIAFMA 1417
H N I+HRD+KGAN+L DS G +++ DFGA+ RL + GTG + GT +M+
Sbjct: 481 HSNMIVHRDIKGANILRDSAG-NVKLGDFGASKRLQTICMSGTG----MRSVTGTPYWMS 535
Query: 1418 PEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHL 1477
PEV+ G+ YGR DVWS+GC ++EM KPPW AE + +A IFKIA+ T P +PSH+
Sbjct: 536 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPW-AEYEA--MAAIFKIATQPTNPQLPSHI 592
Query: 1478 SPGLRDVALRCLELQPQDRPPSRELLKH 1505
S RD LR + ++ + RP + ELL H
Sbjct: 593 SEHGRDF-LRRIFVEARQRPSAEELLTH 619
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 199 bits (505), Expect = 2e-50
Identities = 115/273 (42%), Positives = 165/273 (60%), Gaps = 15/273 (5%)
Query: 1238 REDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRM 1297
R T W G+ +G GAF Y DV TG +AVKQV + + S E + V AL EI++
Sbjct: 351 RAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPD-SPETSKEVNALECEIQL 409
Query: 1298 MSHLNHPNIIRMLGATCE--KSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLR 1355
+ +L H I++ G + + ++F+E+M GGS+ L YGA E+V YT Q+L
Sbjct: 410 LKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILE 469
Query: 1356 GLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGT 1412
G+ YLH N I+HRD+KGAN+L DSTG +++ DFGA+ RL + GTG + GT
Sbjct: 470 GVHYLHSNMIVHRDIKGANILRDSTG-NVKLGDFGASKRLQTICLSGTG----MKSVTGT 524
Query: 1413 IAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPS 1472
+M+PEV+ G+ YGR D+WSV C ++EM KPPW AE + +A IFKIA+ T P
Sbjct: 525 PYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPW-AEFEA--MAAIFKIATQPTNPK 581
Query: 1473 IPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 1505
+P H+S RD L+ + ++ + RP + ELL+H
Sbjct: 582 LPPHVSDYTRDF-LKRIFVEAKLRPSADELLRH 613
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 184 bits (468), Expect = 4e-46
Identities = 119/422 (28%), Positives = 211/422 (50%), Gaps = 39/422 (9%)
Query: 1114 TPVEEKCRLDVNTE--LNSSIEDLLEA---SMPSSDTTVTFKSEVAVLSPEKAENDDTYK 1168
+P +E + D+ + +NSS+++ +A S P+ TV + + + P + +++ +
Sbjct: 91 SPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSR 150
Query: 1169 DDVNHN------QKCKE----------------KMEAEEEEALAIAMAMSASQDALPIVP 1206
+ N N + C E K + + E + + + +
Sbjct: 151 ELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSS 210
Query: 1207 QLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTG 1266
L++ + E+ +I + K+++P W KG+ +G GA+ + Y G
Sbjct: 211 GLRIYDREEKFLISNEKKIFSENSLKSEEPIL----WTKGEILGKGAYGTVYCGL-TSQG 265
Query: 1267 TLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWM 1326
L+AVKQV + E+ L+EE+ ++ L H NI+ LG +++ ++F+E++
Sbjct: 266 QLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFV 325
Query: 1327 AGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRI 1386
GGS++ +++++G E V YT+Q+L+G++YLHEN ++HRD+KG N+++ TG +++
Sbjct: 326 PGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTG-IIKL 384
Query: 1387 ADFGAAARLASKGTGA--GEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC 1444
DFG A RLA G + + GT +MAPEV+ YGR D+WS+GC + EMA
Sbjct: 385 IDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMAT 444
Query: 1445 AKPPWNAEKHSNHLALIFKI-ASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELL 1503
KPP + + +A +F I A P +P H S D CL +RP + +LL
Sbjct: 445 GKPPLAS---MDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLL 501
Query: 1504 KH 1505
KH
Sbjct: 502 KH 503
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 182 bits (463), Expect = 2e-45
Identities = 101/301 (33%), Positives = 166/301 (55%), Gaps = 12/301 (3%)
Query: 1208 LQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGT 1267
L++ + E+ +I + K+++P W KG+ +G GA+ + Y G
Sbjct: 1030 LRIYDREEKFLISNEKKIFSENSLKSEEPIL----WTKGEILGKGAYGTVYCGL-TSQGQ 1084
Query: 1268 LMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMA 1327
L+AVKQV + E+ L+EE+ ++ L H NI+ LG +++ ++F+E++
Sbjct: 1085 LIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVP 1144
Query: 1328 GGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIA 1387
GGS++ +++++G E V YT+Q+L+G++YLHEN ++HRD+KG N+++ TG +++
Sbjct: 1145 GGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTG-IIKLI 1203
Query: 1388 DFGAAARLASKGTGA--GEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACA 1445
DFG A RLA G + + GT +MAPEV+ YGR D+WS+GC + EMA
Sbjct: 1204 DFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATG 1263
Query: 1446 KPPWNAEKHSNHLALIFKI-ASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLK 1504
KPP + + +A +F I A P +P H S D CL +RP + +LLK
Sbjct: 1264 KPPLAS---MDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK 1320
Query: 1505 H 1505
H
Sbjct: 1321 H 1321
>gi|121583542 mitogen-activated protein kinase kinase kinase 15 [Homo
sapiens]
Length = 788
Score = 169 bits (429), Expect = 1e-41
Identities = 98/266 (36%), Positives = 145/266 (54%), Gaps = 19/266 (7%)
Query: 1249 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1308
+G G + Y +D+ +A+K++ + L EEI + +L H NI++
Sbjct: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIP------ERDSRYSQPLHEEIALHKYLKHRNIVQ 186
Query: 1309 MLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFKESVVINYTEQLLRGLSYLHENQIIH 1367
LG+ E +F+E + GGS++ LL SK+G KE + YT+Q+L GL YLHENQI+H
Sbjct: 187 YLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVH 246
Query: 1368 RDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL----RG 1423
RD+KG N+L+++ ++I+DFG + RLA G GT+ +MAPE++ RG
Sbjct: 247 RDIKGDNVLVNTYSGVVKISDFGTSKRLA----GVNPCTETFTGTLQYMAPEIIDQGPRG 302
Query: 1424 QQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRD 1483
YG D+WS+GC IIEMA +KPP++ + A +FK+ P IP LS R
Sbjct: 303 --YGAPADIWSLGCTIIEMATSKPPFH--ELGEPQAAMFKVGMFKIHPEIPEALSAEARA 358
Query: 1484 VALRCLELQPQDRPPSRELLKHPVFR 1509
L C E P R + ELL+ R
Sbjct: 359 FILSCFEPDPHKRATTAELLREGFLR 384
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 164 bits (414), Expect = 8e-40
Identities = 95/260 (36%), Positives = 145/260 (55%), Gaps = 17/260 (6%)
Query: 1249 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1308
+G G + Y +D+ +A+K++ + L EEI + HL H NI++
Sbjct: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIP------ERDSRYSQPLHEEIALHKHLKHKNIVQ 739
Query: 1309 MLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFK--ESVVINYTEQLLRGLSYLHENQI 1365
LG+ E +F+E + GGS++ LL SK+G K E + YT+Q+L GL YLH+NQI
Sbjct: 740 YLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 799
Query: 1366 IHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQ 1424
+HRD+KG N+LI++ L+I+DFG + RLA G GT+ +MAPE++ +G
Sbjct: 800 VHRDIKGDNVLINTYSGVLKISDFGTSKRLA----GINPCTETFTGTLQYMAPEIIDKGP 855
Query: 1425 Q-YGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRD 1483
+ YG++ D+WS+GC IIEMA KPP+ + A +FK+ P IP +S +
Sbjct: 856 RGYGKAADIWSLGCTIIEMATGKPPF--YELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
Query: 1484 VALRCLELQPQDRPPSRELL 1503
L+C E P R + +LL
Sbjct: 914 FILKCFEPDPDKRACANDLL 933
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 162 bits (411), Expect = 2e-39
Identities = 86/267 (32%), Positives = 151/267 (56%), Gaps = 13/267 (4%)
Query: 1242 EWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL 1301
+W +G +IG G + Y V TG LMA+K++ + N + ++ +E+++ +
Sbjct: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN----DHKTIKETADELKIFEGI 1397
Query: 1302 NHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLH 1361
HPN++R G + +F+E+ G++ + S+ G +E V+ Y++Q+ ++ LH
Sbjct: 1398 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLH 1455
Query: 1362 ENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL 1421
E+ I+HRD+KGAN+ + S+G +++ DFG + +L + LGT A+MAPEV+
Sbjct: 1456 EHGIVHRDIKGANIFLTSSGL-IKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI 1514
Query: 1422 ---RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLS 1478
+G+ +GR+ D+WS+GC +IEM K PW+ +H + +++K+ P IP LS
Sbjct: 1515 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH--NFQIMYKVGMG-HKPPIPERLS 1571
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKH 1505
P +D CLE P+ R + +LL H
Sbjct: 1572 PEGKDFLSHCLESDPKMRWTASQLLDH 1598
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 162 bits (411), Expect = 2e-39
Identities = 86/267 (32%), Positives = 151/267 (56%), Gaps = 13/267 (4%)
Query: 1242 EWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL 1301
+W +G +IG G + Y V TG LMA+K++ + N + ++ +E+++ +
Sbjct: 1292 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN----DHKTIKETADELKIFEGI 1347
Query: 1302 NHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLH 1361
HPN++R G + +F+E+ G++ + S+ G +E V+ Y++Q+ ++ LH
Sbjct: 1348 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLH 1405
Query: 1362 ENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL 1421
E+ I+HRD+KGAN+ + S+G +++ DFG + +L + LGT A+MAPEV+
Sbjct: 1406 EHGIVHRDIKGANIFLTSSGL-IKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI 1464
Query: 1422 ---RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLS 1478
+G+ +GR+ D+WS+GC +IEM K PW+ +H + +++K+ P IP LS
Sbjct: 1465 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH--NFQIMYKVGMG-HKPPIPERLS 1521
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKH 1505
P +D CLE P+ R + +LL H
Sbjct: 1522 PEGKDFLSHCLESDPKMRWTASQLLDH 1548
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 155 bits (391), Expect = 4e-37
Identities = 97/275 (35%), Positives = 150/275 (54%), Gaps = 21/275 (7%)
Query: 1239 EDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMM 1298
E TE + +G G + Y +D T +A+K++ + L EEI +
Sbjct: 644 EYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP------ERDSRFSQPLHEEIALH 697
Query: 1299 SHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFK--ESVVINYTEQLLR 1355
L H NI+R LG+ + +F+E + GGS++ LL S +G K ES + YT Q+L+
Sbjct: 698 RRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQ 757
Query: 1356 GLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAF 1415
GL YLH+N I+HRD+KG N+LI++ L+I+DFG + RLA G GT+ +
Sbjct: 758 GLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA----GITPCTETFTGTLQY 813
Query: 1416 MAPEVL----RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAP 1471
MAPE++ RG YG++ D+WS+GC +IEMA +PP++ + + A +F++ P
Sbjct: 814 MAPEIIDQGPRG--YGKAADIWSLGCTVIEMATGRPPFH--ELGSPQAAMFQVGMYKVHP 869
Query: 1472 SIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHP 1506
+PS LS + LR E P+ R ++ LL P
Sbjct: 870 PMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDP 904
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 145 bits (367), Expect = 2e-34
Identities = 96/309 (31%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 1198 SQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSC 1257
S+ LP P+ N E+ + +Q E+ K +Q ED E G+ +G G F +
Sbjct: 98 SKQPLPSAPE---NNPEEELASKQKNEES-----KKRQWALEDFEI--GRPLGKGKFGNV 147
Query: 1258 YQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS 1317
Y A++ + ++A+K + E+ V LR E+ + SHL HPNI+R+ G + +
Sbjct: 148 YLAREKQSKFILALKVLF---KAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT 204
Query: 1318 NYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI 1377
L +E+ G+V L K F E Y +L LSY H ++IHRD+K NLL+
Sbjct: 205 RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 264
Query: 1378 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGC 1437
S G+ L+IADFG + S + L GT+ ++ PE++ G+ + D+WS+G
Sbjct: 265 GSAGE-LKIADFGWSVHAPSSR------RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGV 317
Query: 1438 AIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRP 1497
E KPP+ A + I ++ + P ++ G RD+ R L+ P RP
Sbjct: 318 LCYEFLVGKPPFEANTYQETYKRISRVEF-----TFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 1498 PSRELLKHP 1506
RE+L+HP
Sbjct: 373 MLREVLEHP 381
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 145 bits (367), Expect = 2e-34
Identities = 96/309 (31%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 1198 SQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSC 1257
S+ LP P+ N E+ + +Q E+ K +Q ED E G+ +G G F +
Sbjct: 98 SKQPLPSAPE---NNPEEELASKQKNEES-----KKRQWALEDFEI--GRPLGKGKFGNV 147
Query: 1258 YQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS 1317
Y A++ + ++A+K + E+ V LR E+ + SHL HPNI+R+ G + +
Sbjct: 148 YLAREKQSKFILALKVLF---KAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT 204
Query: 1318 NYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI 1377
L +E+ G+V L K F E Y +L LSY H ++IHRD+K NLL+
Sbjct: 205 RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 264
Query: 1378 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGC 1437
S G+ L+IADFG + S + L GT+ ++ PE++ G+ + D+WS+G
Sbjct: 265 GSAGE-LKIADFGWSVHAPSSR------RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGV 317
Query: 1438 AIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRP 1497
E KPP+ A + I ++ + P ++ G RD+ R L+ P RP
Sbjct: 318 LCYEFLVGKPPFEANTYQETYKRISRVEF-----TFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 1498 PSRELLKHP 1506
RE+L+HP
Sbjct: 373 MLREVLEHP 381
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 145 bits (367), Expect = 2e-34
Identities = 96/309 (31%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 1198 SQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSC 1257
S+ LP P+ N E+ + +Q E+ K +Q ED E G+ +G G F +
Sbjct: 98 SKQPLPSAPE---NNPEEELASKQKNEES-----KKRQWALEDFEI--GRPLGKGKFGNV 147
Query: 1258 YQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS 1317
Y A++ + ++A+K + E+ V LR E+ + SHL HPNI+R+ G + +
Sbjct: 148 YLAREKQSKFILALKVLF---KAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT 204
Query: 1318 NYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI 1377
L +E+ G+V L K F E Y +L LSY H ++IHRD+K NLL+
Sbjct: 205 RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 264
Query: 1378 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGC 1437
S G+ L+IADFG + S + L GT+ ++ PE++ G+ + D+WS+G
Sbjct: 265 GSAGE-LKIADFGWSVHAPSSR------RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGV 317
Query: 1438 AIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRP 1497
E KPP+ A + I ++ + P ++ G RD+ R L+ P RP
Sbjct: 318 LCYEFLVGKPPFEANTYQETYKRISRVEF-----TFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 1498 PSRELLKHP 1506
RE+L+HP
Sbjct: 373 MLREVLEHP 381
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 145 bits (367), Expect = 2e-34
Identities = 96/309 (31%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 1198 SQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSC 1257
S+ LP P+ N E+ + +Q E+ K +Q ED E G+ +G G F +
Sbjct: 98 SKQPLPSAPE---NNPEEELASKQKNEES-----KKRQWALEDFEI--GRPLGKGKFGNV 147
Query: 1258 YQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS 1317
Y A++ + ++A+K + E+ V LR E+ + SHL HPNI+R+ G + +
Sbjct: 148 YLAREKQSKFILALKVLF---KAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT 204
Query: 1318 NYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI 1377
L +E+ G+V L K F E Y +L LSY H ++IHRD+K NLL+
Sbjct: 205 RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 264
Query: 1378 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGC 1437
S G+ L+IADFG + S + L GT+ ++ PE++ G+ + D+WS+G
Sbjct: 265 GSAGE-LKIADFGWSVHAPSSR------RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGV 317
Query: 1438 AIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRP 1497
E KPP+ A + I ++ + P ++ G RD+ R L+ P RP
Sbjct: 318 LCYEFLVGKPPFEANTYQETYKRISRVEF-----TFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 1498 PSRELLKHP 1506
RE+L+HP
Sbjct: 373 MLREVLEHP 381
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 145 bits (367), Expect = 2e-34
Identities = 96/309 (31%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 1198 SQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSC 1257
S+ LP P+ N E+ + +Q E+ K +Q ED E G+ +G G F +
Sbjct: 98 SKQPLPSAPE---NNPEEELASKQKNEES-----KKRQWALEDFEI--GRPLGKGKFGNV 147
Query: 1258 YQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS 1317
Y A++ + ++A+K + E+ V LR E+ + SHL HPNI+R+ G + +
Sbjct: 148 YLAREKQSKFILALKVLF---KAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT 204
Query: 1318 NYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI 1377
L +E+ G+V L K F E Y +L LSY H ++IHRD+K NLL+
Sbjct: 205 RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 264
Query: 1378 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGC 1437
S G+ L+IADFG + S + L GT+ ++ PE++ G+ + D+WS+G
Sbjct: 265 GSAGE-LKIADFGWSVHAPSSR------RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGV 317
Query: 1438 AIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRP 1497
E KPP+ A + I ++ + P ++ G RD+ R L+ P RP
Sbjct: 318 LCYEFLVGKPPFEANTYQETYKRISRVEF-----TFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 1498 PSRELLKHP 1506
RE+L+HP
Sbjct: 373 MLREVLEHP 381
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 145 bits (367), Expect = 2e-34
Identities = 96/309 (31%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 1198 SQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSC 1257
S+ LP P+ N E+ + +Q E+ K +Q ED E G+ +G G F +
Sbjct: 98 SKQPLPSAPE---NNPEEELASKQKNEES-----KKRQWALEDFEI--GRPLGKGKFGNV 147
Query: 1258 YQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS 1317
Y A++ + ++A+K + E+ V LR E+ + SHL HPNI+R+ G + +
Sbjct: 148 YLAREKQSKFILALKVLF---KAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT 204
Query: 1318 NYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI 1377
L +E+ G+V L K F E Y +L LSY H ++IHRD+K NLL+
Sbjct: 205 RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 264
Query: 1378 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGC 1437
S G+ L+IADFG + S + L GT+ ++ PE++ G+ + D+WS+G
Sbjct: 265 GSAGE-LKIADFGWSVHAPSSR------RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGV 317
Query: 1438 AIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRP 1497
E KPP+ A + I ++ + P ++ G RD+ R L+ P RP
Sbjct: 318 LCYEFLVGKPPFEANTYQETYKRISRVEF-----TFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 1498 PSRELLKHP 1506
RE+L+HP
Sbjct: 373 MLREVLEHP 381
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 140 bits (354), Expect = 7e-33
Identities = 90/275 (32%), Positives = 147/275 (53%), Gaps = 17/275 (6%)
Query: 1233 AKQPYREDTEWL--KGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEA 1290
A Q R D E L K +IG G+F Y+ D T ++A+K + E E+ +E
Sbjct: 8 ANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL-----EEAEDEIED 62
Query: 1291 LREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYT 1350
+++EI ++S + P I R G+ + + + +E++ GGS LL K G +E+ +
Sbjct: 63 IQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATIL 121
Query: 1351 EQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLL 1410
++L+GL YLH + IHRD+K AN+L+ G +++ADFG A +L F +
Sbjct: 122 REILKGLDYLHSERKIHRDIKAANVLLSEQGD-VKLADFGVAGQLTDTQIKRNTF----V 176
Query: 1411 GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTA 1470
GT +MAPEV++ Y D+WS+G IE+A +PP N++ H + ++F I +
Sbjct: 177 GTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP-NSDLHP--MRVLFLIPK-NSP 232
Query: 1471 PSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 1505
P++ S ++ CL P+ RP ++ELLKH
Sbjct: 233 PTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKH 267
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 139 bits (349), Expect = 3e-32
Identities = 87/271 (32%), Positives = 131/271 (48%), Gaps = 13/271 (4%)
Query: 1238 REDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRM 1297
R +LKG+ +G G F+ CY+A D TG+ AVK + R Q E + EI +
Sbjct: 57 RSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKI---LNEIEL 113
Query: 1298 MSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGL 1357
L H +I+R + N +F+E + S+AH+ E V Y Q+L GL
Sbjct: 114 HRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGL 173
Query: 1358 SYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMA 1417
YLH+ I+HRD+K N I + L++ DFG AARL + + + GT ++A
Sbjct: 174 KYLHQRGILHRDLKLGNFFI-TENMELKVGDFGLAARLEP----PEQRKKTICGTPNYVA 228
Query: 1418 PEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHL 1477
PEVL Q +G DVWS+GC + + C PP+ I ++ ++P+ L
Sbjct: 229 PEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHY-----TLPASL 283
Query: 1478 SPGLRDVALRCLELQPQDRPPSRELLKHPVF 1508
S R + L P+DRP ++L+H F
Sbjct: 284 SLPARQLLAAILRASPRDRPSIDQILRHDFF 314
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 137 bits (346), Expect = 6e-32
Identities = 88/282 (31%), Positives = 150/282 (53%), Gaps = 18/282 (6%)
Query: 1226 TLPGHTKAKQPYREDTEWL--KGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSE 1283
TLP H + D E L K ++IG G+F ++ D T ++A+K + E
Sbjct: 18 TLP-HPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL-----EE 71
Query: 1284 QEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKE 1343
E+ +E +++EI ++S + P + + G+ + + + +E++ GGS LL G E
Sbjct: 72 AEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDE 130
Query: 1344 SVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAG 1403
+ + ++L+GL YLH + IHRD+K AN+L+ G+ +++ADFG A +L
Sbjct: 131 TQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGE-VKLADFGVAGQLTDTQIKRN 189
Query: 1404 EFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFK 1463
F +GT +MAPEV++ Y D+WS+G IE+A +PP ++E H + ++F
Sbjct: 190 TF----VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPP-HSELHP--MKVLFL 242
Query: 1464 IASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 1505
I P++ + S L++ CL +P RP ++ELLKH
Sbjct: 243 IPK-NNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKH 283
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 137 bits (344), Expect = 1e-31
Identities = 84/269 (31%), Positives = 146/269 (54%), Gaps = 16/269 (5%)
Query: 1242 EWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL 1301
++ + ++IG GA + + A DV G +A+KQ+ +++ E + EI +M L
Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINL------QKQPKKELIINEILVMKEL 301
Query: 1302 NHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLH 1361
+PNI+ L + + +E++AGGS+ ++++ E+ + + L+ L +LH
Sbjct: 302 KNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLH 360
Query: 1362 ENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL 1421
NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPEV+
Sbjct: 361 ANQVIHRDIKSDNVLLGMEGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPEVV 415
Query: 1422 RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLSPG 1480
+ YG D+WS+G IEM +PP+ E N L ++ IA + T P LSP
Sbjct: 416 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPEKLSPI 472
Query: 1481 LRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ + R ++ELL+HP +
Sbjct: 473 FRDFLNRCLEMDVEKRGSAKELLQHPFLK 501
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 137 bits (344), Expect = 1e-31
Identities = 86/279 (30%), Positives = 148/279 (53%), Gaps = 17/279 (6%)
Query: 1227 LPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEE 1286
LPG K E + K ++IG G+F ++ D T ++A+K + E E+
Sbjct: 10 LPGMQNLKADPEE--LFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL-----EEAED 62
Query: 1287 VVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVV 1346
+E +++EI ++S + P + + G+ + + + +E++ GGS LL G E+ +
Sbjct: 63 EIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQI 121
Query: 1347 INYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQ 1406
++L+GL YLH + IHRD+K AN+L+ G+ +++ADFG A +L F
Sbjct: 122 ATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGE-VKLADFGVAGQLTDTQIKRNTF- 179
Query: 1407 GQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIAS 1466
+GT +MAPEV++ Y D+WS+G IE+A +PP ++E H + ++F I
Sbjct: 180 ---VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPP-HSELHP--MKVLFLIPK 233
Query: 1467 ATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 1505
P++ + S L++ CL +P RP ++ELLKH
Sbjct: 234 -NNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKH 271
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 136 bits (343), Expect = 1e-31
Identities = 108/391 (27%), Positives = 182/391 (46%), Gaps = 41/391 (10%)
Query: 1138 ASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA 1197
A+ PSS T SE + P E D+ +++ + N+ + E +I
Sbjct: 167 AAHPSSTKTA---SEPPLAPPVSEEEDEEEEEEEDENEP-PPVIAPRPEHTKSIYTRSVV 222
Query: 1198 SQDALPIVPQLQV-----ENGEDIIIIQ-------------QDTPETLPGHTKAKQPYRE 1239
A P VP +V EN + + ++ E L P ++
Sbjct: 223 ESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKK 282
Query: 1240 DTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMS 1299
T + ++IG GA + Y A D+ TG +A+KQ+ +Q+ E + EI +M
Sbjct: 283 YTRF---EKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIINEILVMR 333
Query: 1300 HLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSY 1359
+PNI+ L + + +E++AGGS+ ++++ E + + L+ L +
Sbjct: 334 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 392
Query: 1360 LHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE 1419
LH NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPE
Sbjct: 393 LHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPE 447
Query: 1420 VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLS 1478
V+ + YG D+WS+G IEM +PP+ E N L ++ IA + T P LS
Sbjct: 448 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPERLS 504
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ R ++ELL+HP +
Sbjct: 505 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 535
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 136 bits (343), Expect = 1e-31
Identities = 108/391 (27%), Positives = 182/391 (46%), Gaps = 41/391 (10%)
Query: 1138 ASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA 1197
A+ PSS T SE + P E D+ +++ + N+ + E +I
Sbjct: 173 AAHPSSTKTA---SEPPLAPPVSEEEDEEEEEEEDENEP-PPVIAPRPEHTKSIYTRSVV 228
Query: 1198 SQDALPIVPQLQV-----ENGEDIIIIQ-------------QDTPETLPGHTKAKQPYRE 1239
A P VP +V EN + + ++ E L P ++
Sbjct: 229 ESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKK 288
Query: 1240 DTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMS 1299
T + ++IG GA + Y A D+ TG +A+KQ+ +Q+ E + EI +M
Sbjct: 289 YTRF---EKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIINEILVMR 339
Query: 1300 HLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSY 1359
+PNI+ L + + +E++AGGS+ ++++ E + + L+ L +
Sbjct: 340 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 398
Query: 1360 LHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE 1419
LH NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPE
Sbjct: 399 LHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPE 453
Query: 1420 VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLS 1478
V+ + YG D+WS+G IEM +PP+ E N L ++ IA + T P LS
Sbjct: 454 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPERLS 510
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ R ++ELL+HP +
Sbjct: 511 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 541
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 136 bits (343), Expect = 1e-31
Identities = 108/391 (27%), Positives = 182/391 (46%), Gaps = 41/391 (10%)
Query: 1138 ASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA 1197
A+ PSS T SE + P E D+ +++ + N+ + E +I
Sbjct: 188 AAHPSSTKTA---SEPPLAPPVSEEEDEEEEEEEDENEP-PPVIAPRPEHTKSIYTRSVV 243
Query: 1198 SQDALPIVPQLQV-----ENGEDIIIIQ-------------QDTPETLPGHTKAKQPYRE 1239
A P VP +V EN + + ++ E L P ++
Sbjct: 244 ESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKK 303
Query: 1240 DTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMS 1299
T + ++IG GA + Y A D+ TG +A+KQ+ +Q+ E + EI +M
Sbjct: 304 YTRF---EKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIINEILVMR 354
Query: 1300 HLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSY 1359
+PNI+ L + + +E++AGGS+ ++++ E + + L+ L +
Sbjct: 355 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 413
Query: 1360 LHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE 1419
LH NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPE
Sbjct: 414 LHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPE 468
Query: 1420 VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLS 1478
V+ + YG D+WS+G IEM +PP+ E N L ++ IA + T P LS
Sbjct: 469 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPERLS 525
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ R ++ELL+HP +
Sbjct: 526 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 556
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 136 bits (343), Expect = 1e-31
Identities = 108/391 (27%), Positives = 182/391 (46%), Gaps = 41/391 (10%)
Query: 1138 ASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA 1197
A+ PSS T SE + P E D+ +++ + N+ + E +I
Sbjct: 152 AAHPSSTKTA---SEPPLAPPVSEEEDEEEEEEEDENEP-PPVIAPRPEHTKSIYTRSVV 207
Query: 1198 SQDALPIVPQLQV-----ENGEDIIIIQ-------------QDTPETLPGHTKAKQPYRE 1239
A P VP +V EN + + ++ E L P ++
Sbjct: 208 ESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKK 267
Query: 1240 DTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMS 1299
T + ++IG GA + Y A D+ TG +A+KQ+ +Q+ E + EI +M
Sbjct: 268 YTRF---EKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIINEILVMR 318
Query: 1300 HLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSY 1359
+PNI+ L + + +E++AGGS+ ++++ E + + L+ L +
Sbjct: 319 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 377
Query: 1360 LHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE 1419
LH NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPE
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPE 432
Query: 1420 VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLS 1478
V+ + YG D+WS+G IEM +PP+ E N L ++ IA + T P LS
Sbjct: 433 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPERLS 489
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ R ++ELL+HP +
Sbjct: 490 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 520
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 136 bits (343), Expect = 1e-31
Identities = 108/391 (27%), Positives = 182/391 (46%), Gaps = 41/391 (10%)
Query: 1138 ASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA 1197
A+ PSS T SE + P E D+ +++ + N+ + E +I
Sbjct: 152 AAHPSSTKTA---SEPPLAPPVSEEEDEEEEEEEDENEP-PPVIAPRPEHTKSIYTRSVV 207
Query: 1198 SQDALPIVPQLQV-----ENGEDIIIIQ-------------QDTPETLPGHTKAKQPYRE 1239
A P VP +V EN + + ++ E L P ++
Sbjct: 208 ESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKK 267
Query: 1240 DTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMS 1299
T + ++IG GA + Y A D+ TG +A+KQ+ +Q+ E + EI +M
Sbjct: 268 YTRF---EKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIINEILVMR 318
Query: 1300 HLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSY 1359
+PNI+ L + + +E++AGGS+ ++++ E + + L+ L +
Sbjct: 319 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 377
Query: 1360 LHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE 1419
LH NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPE
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPE 432
Query: 1420 VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLS 1478
V+ + YG D+WS+G IEM +PP+ E N L ++ IA + T P LS
Sbjct: 433 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPERLS 489
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ R ++ELL+HP +
Sbjct: 490 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 520
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 136 bits (343), Expect = 1e-31
Identities = 108/391 (27%), Positives = 182/391 (46%), Gaps = 41/391 (10%)
Query: 1138 ASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA 1197
A+ PSS T SE + P E D+ +++ + N+ + E +I
Sbjct: 152 AAHPSSTKTA---SEPPLAPPVSEEEDEEEEEEEDENEP-PPVIAPRPEHTKSIYTRSVV 207
Query: 1198 SQDALPIVPQLQV-----ENGEDIIIIQ-------------QDTPETLPGHTKAKQPYRE 1239
A P VP +V EN + + ++ E L P ++
Sbjct: 208 ESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKK 267
Query: 1240 DTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMS 1299
T + ++IG GA + Y A D+ TG +A+KQ+ +Q+ E + EI +M
Sbjct: 268 YTRF---EKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIINEILVMR 318
Query: 1300 HLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSY 1359
+PNI+ L + + +E++AGGS+ ++++ E + + L+ L +
Sbjct: 319 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 377
Query: 1360 LHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE 1419
LH NQ+IHRD+K N+L+ G +++ DFG A++ + + + ++GT +MAPE
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK----RSTMVGTPYWMAPE 432
Query: 1420 VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLS 1478
V+ + YG D+WS+G IEM +PP+ E N L ++ IA + T P LS
Sbjct: 433 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELQNPERLS 489
Query: 1479 PGLRDVALRCLELQPQDRPPSRELLKHPVFR 1509
RD RCLE+ R ++ELL+HP +
Sbjct: 490 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 520
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 135 bits (339), Expect = 4e-31
Identities = 94/266 (35%), Positives = 145/266 (54%), Gaps = 21/266 (7%)
Query: 1248 QIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNII 1307
++G GAF Y+AQ+ T L A K + +T SE+E +E EI +++ +HPNI+
Sbjct: 39 ELGDGAFGKVYKAQNKETSVLAAAKVI----DTKSEEE--LEDYMVEIDILASCDHPNIV 92
Query: 1308 RMLGATCEKSNYNLFIEWMAGGSV-AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQII 1366
++L A ++N + IE+ AGG+V A +L ES + +Q L L+YLH+N+II
Sbjct: 93 KLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKII 152
Query: 1367 HRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL----- 1421
HRD+K N+L G +++ADFG +A K T + + +GT +MAPEV+
Sbjct: 153 HRDLKAGNILFTLDGD-IKLADFGVSA----KNTRTIQRRDSFIGTPYWMAPEVVMCETS 207
Query: 1422 RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA-SATTAPSIPSHLSPG 1480
+ + Y DVWS+G +IEMA +PP N + ++ KIA S + PS S
Sbjct: 208 KDRPYDYKADVWSLGITLIEMAEIEPP---HHELNPMRVLLKIAKSEPPTLAQPSRWSSN 264
Query: 1481 LRDVALRCLELQPQDRPPSRELLKHP 1506
+D +CLE R + +LL+HP
Sbjct: 265 FKDFLKKCLEKNVDARWTTSQLLQHP 290
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 133 bits (335), Expect = 1e-30
Identities = 79/261 (30%), Positives = 136/261 (52%), Gaps = 15/261 (5%)
Query: 1249 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1308
+G GAF + L+ +KQ+ + T E++ A + E +++ LNHPN+I
Sbjct: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQ----AAQNECQVLKLLNHPNVIE 65
Query: 1309 MLGATCEKSNYNLFIEWMAGGSVAHLLSKY--GAFKESVVINYTEQLLRGLSYLHENQII 1366
E + +E+ GG++A + K +E ++++ Q+L L ++H + I+
Sbjct: 66 YYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLIL 125
Query: 1367 HRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQY 1426
HRD+K N+L+D ++I DFG + L+SK ++GT +++PE+ G+ Y
Sbjct: 126 HRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAY-----TVVGTPCYISPELCEGKPY 180
Query: 1427 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVAL 1486
+ D+W++GC + E+A K + A +N AL+ KI S T AP I SP LR + L
Sbjct: 181 NQKSDIWALGCVLYELASLKRAFEA---ANLPALVLKIMSGTFAP-ISDRYSPELRQLVL 236
Query: 1487 RCLELQPQDRPPSRELLKHPV 1507
L L+P RPP ++ P+
Sbjct: 237 SLLSLEPAQRPPLSHIMAQPL 257
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,455,121
Number of Sequences: 37866
Number of extensions: 3374443
Number of successful extensions: 26589
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 716
Number of HSP's successfully gapped in prelim test: 999
Number of HSP's that attempted gapping in prelim test: 18667
Number of HSP's gapped (non-prelim): 6839
length of query: 1512
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1397
effective length of database: 13,892,928
effective search space: 19408420416
effective search space used: 19408420416
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.