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Search of human proteins with 153266841
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153266841 apolipoprotein H precursor [Homo sapiens]
(345 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153266841 apolipoprotein H precursor [Homo sapiens] 748 0.0
gi|157419154 selectin P precursor [Homo sapiens] 117 2e-26
gi|148886654 polydom [Homo sapiens] 115 7e-26
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 113 3e-25
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 109 3e-24
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 109 3e-24
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 109 3e-24
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 109 4e-24
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 109 4e-24
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 109 4e-24
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 108 5e-24
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 106 3e-23
gi|4502503 complement component 4 binding protein, alpha chain p... 105 5e-23
gi|187960042 selectin E precursor [Homo sapiens] 105 6e-23
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 101 1e-21
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 100 3e-21
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 100 3e-21
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 96 5e-20
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 95 8e-20
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 95 8e-20
gi|118442839 complement factor H-related 1 [Homo sapiens] 91 1e-18
gi|239758113 PREDICTED: similar to complement factor H-related 1... 91 1e-18
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 91 2e-18
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 748 bits (1930), Expect = 0.0
Identities = 345/345 (100%), Positives = 345/345 (100%)
Query: 1 MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG 60
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG
Sbjct: 1 MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG 60
Query: 61 MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD 120
MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD
Sbjct: 61 MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD 120
Query: 121 SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM 180
SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM
Sbjct: 121 SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM 180
Query: 181 FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL 240
FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL
Sbjct: 181 FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL 240
Query: 241 DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC 300
DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC
Sbjct: 241 DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC 300
Query: 301 KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC 345
KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC
Sbjct: 301 KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC 345
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 117 bits (292), Expect = 2e-26
Identities = 75/249 (30%), Positives = 107/249 (42%), Gaps = 12/249 (4%)
Query: 26 PDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW--PINT---LKCT 80
P + V PL T + G + C+PGY R G+ C +G W P+ T + C
Sbjct: 330 PSEGTMDCVHPL-TAFAYGSSCKFECQPGYRVR-GLDMLRCIDSGHWSAPLPTCEAISCE 387
Query: 81 PRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI 140
P P G ++ + F+Y SF C GF L GAD +C G+W+ PVC +
Sbjct: 388 PLESPVHGSMD-CSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQAL 446
Query: 141 ICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PE 199
C +P A + P Y+ F C + G + C GNW + PE
Sbjct: 447 QCQDLPVPNEARVNCSHPFGAFR--YQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE 504
Query: 200 CREVKCPFPSRPDNGFVN-YPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258
C+ + C P NG + + YK F C +GYSL GPE ++CT+ G W+ P
Sbjct: 505 CQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSP 564
Query: 259 SCKASCKVP 267
+ K P
Sbjct: 565 PMCEAIKCP 573
Score = 109 bits (272), Expect = 4e-24
Identities = 65/224 (29%), Positives = 100/224 (44%), Gaps = 10/224 (4%)
Query: 46 EITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYT----TFE 101
+ ++ C GY G K C +G+W +C CP I E G + F+
Sbjct: 225 QCSFHCTDGY-QVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQ 283
Query: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAG 161
+ ++ SFSC GF L G + +CT G W+ PVC + C P+ T+ P
Sbjct: 284 HQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTA 343
Query: 162 NNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVN-YP 219
Y + FEC P + + G D + C G+W+ LP C + C P +G ++ P
Sbjct: 344 --FAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSP 401
Query: 220 AKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262
+ Y +F C +G+ L G + + C LG W+A P C+A
Sbjct: 402 SLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
Score = 109 bits (272), Expect = 4e-24
Identities = 66/227 (29%), Positives = 96/227 (42%), Gaps = 10/227 (4%)
Query: 48 TYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR----YTTFEYP 103
++ C G++ RG C G W C C + V + F Y
Sbjct: 413 SFRCAEGFMLRGA-DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQ 471
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
+ SF+CN G L GA +C G W+ P C I C P P T+ +P +
Sbjct: 472 SVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPL--GS 529
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-CREVKCPFPSRPDNGFVN-YPAK 221
S Y+ T F C +++ G + + CT G WT P C +KCP P+ G ++ +
Sbjct: 530 SSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTR 589
Query: 222 PTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSCKASCKVP 267
F C +G+ L+GP +ECT G WSA P+CK +P
Sbjct: 590 GEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLP 636
Score = 93.6 bits (231), Expect = 2e-19
Identities = 67/248 (27%), Positives = 105/248 (42%), Gaps = 27/248 (10%)
Query: 49 YSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTT----FEYPN 104
+ C GY S G + C +G W + C CP E G++ + F +
Sbjct: 538 FICDEGY-SLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
Query: 105 TISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPP------PSIPTFATLRVYKP 158
T FSC+ GF L G ++ +CT G+WS P C I P P++ T +Y
Sbjct: 597 TCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
Query: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PECREVKC-------PFPSR 210
+ T F C + G+ T++C G WT + P CR VKC P
Sbjct: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN 716
Query: 211 PDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKASCKVPVK 269
N + N+ Y +F C +G L+G + C + G+WS +P+C+A + ++
Sbjct: 717 CSNLWGNFS------YGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAG-PLTIQ 769
Query: 270 KATVVYQG 277
+A + G
Sbjct: 770 EALTYFGG 777
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/223 (26%), Positives = 93/223 (41%), Gaps = 12/223 (5%)
Query: 48 TYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR----YTTFEYP 103
++SC+ G+ + G C +G+W C C G + T F Y
Sbjct: 289 SFSCEEGF-ALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYG 347
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
++ F C G+ + G D +C + G WS LP C I C P P ++ PS
Sbjct: 348 SSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDC-SPSL-RA 405
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVN--YPA 220
Y F C + G D + C G WT P C+ ++C P+ VN +P
Sbjct: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPF 465
Query: 221 KPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSCKA 262
Y+ +F C++G L G ++C GNW+++ P C+A
Sbjct: 466 -GAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQA 507
Score = 88.2 bits (217), Expect = 1e-17
Identities = 51/181 (28%), Positives = 81/181 (44%), Gaps = 6/181 (3%)
Query: 89 ILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIP 148
+L N + F + + SF C G+ +NG +C G W+ + P C CPP IP
Sbjct: 209 VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIP 268
Query: 149 TFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPF 207
+ + ++ + F C A+ G + + CT G WT P C+ V+C
Sbjct: 269 ERGNMTCLHSAKAFQ--HQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQH 326
Query: 208 PSRPDNGFVNYPAKPTLY-YKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA-SC 264
P G ++ T + Y F C GY + G + + C G+WSA +P+C+A SC
Sbjct: 327 LEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISC 386
Query: 265 K 265
+
Sbjct: 387 E 387
Score = 87.8 bits (216), Expect = 1e-17
Identities = 63/235 (26%), Positives = 98/235 (41%), Gaps = 28/235 (11%)
Query: 48 TYSCKPGYVSRGGMRKFICPLTGLW-----PINTLKCTPRVCPFAGILENGAVRYT---- 98
+++C G + G C TG W + CTP + P +NG +
Sbjct: 475 SFTCNEGLLLVGAS-VLQCLATGNWNSVPPECQAIPCTPLLSP-----QNGTMTCVQPLG 528
Query: 99 TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKP 158
+ Y +T F C+ G+ L+G + CT G+W+ P+C I CP P +L
Sbjct: 529 SSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDT 588
Query: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-CRE--------VKCPFPS 209
N T F C + G + + CTT G W+ P C+ V+CP +
Sbjct: 589 RGEFN--VGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALT 646
Query: 210 RPDNGFVNYPAKP-TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSCKA 262
P G + P T + FGC+ G++L G + C G W+A+ P+C+A
Sbjct: 647 TPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRA 701
Score = 60.8 bits (146), Expect = 2e-09
Identities = 49/180 (27%), Positives = 66/180 (36%), Gaps = 28/180 (15%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC-------TPRV-CPFAGILEN 92
+ G +SC G+ G C +G W C TP V CP
Sbjct: 592 FNVGSTCHFSCDNGFKLEGP-NNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ 650
Query: 93 GAVRYT----TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIP 148
G + TF + T F CN GF L G + C G+W+ P C + C
Sbjct: 651 GTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKC------ 704
Query: 149 TFATLRVYKPSAGN------NSLYRDTAVFECLPQHAMFGNDTITCTTHGNW-TKLPECR 201
+ L V KP A N N Y F CL + G+ C +G+W T +P C+
Sbjct: 705 --SELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/103 (31%), Positives = 48/103 (46%), Gaps = 15/103 (14%)
Query: 173 ECLPQHAMFGNDTITCTT--HGNWTKLPECREVK-CPFPSRPDNGFVN--YPAKPTLYYK 227
ECL GN T +C +G PEC V+ C P + +N +P +
Sbjct: 173 ECLET---IGNYTCSCYPGFYG-----PECEYVRECGELELPQHVLMNCSHPLG-NFSFN 223
Query: 228 DKATFGCHDGYSLDGPEEIECTKLGNW-SAMPSCKASCKVPVK 269
+ +F C DGY ++GP ++EC G W + P C A+ P+K
Sbjct: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLK 266
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 115 bits (287), Expect = 7e-26
Identities = 82/296 (27%), Positives = 121/296 (40%), Gaps = 27/296 (9%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLW-PINTLKCTPRVCPFAGILENGAVRYTT 99
+E G ++ + C GY G + C +G W + KC P CP +LEN V
Sbjct: 2280 FEVGSKVQFFCNEGYELVGDS-SWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKEL 2338
Query: 100 FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
++FSC G L G KC +W+ PVC ++C PP + +F P
Sbjct: 2339 TTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGV-----PI 2393
Query: 160 AGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK-LPECREVKCPFPSRPDNGFVNY 218
+ + T + C+ + GN T C G W+ LPEC V+CP P NG ++
Sbjct: 2394 PSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDV 2453
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW-SAMPSCKASCKVPVKKATVVYQG 277
L Y A + C G+ L G C + G+W P+CKA + K + G
Sbjct: 2454 QG---LAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKA---IECLKPKEILNG 2507
Query: 278 ERVKIQEKFKNGMLH-GDKVSFFCKNKEKKCSYTEDAQCI---DGTIEVPKCFKEH 329
KF LH G V++ C N+ + C+ D ++ P C H
Sbjct: 2508 -------KFSYTDLHYGQTVTYSC-NRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555
Score = 112 bits (281), Expect = 4e-25
Identities = 76/256 (29%), Positives = 107/256 (41%), Gaps = 18/256 (7%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
+C KP+ VV K +E I Y C+PGY G R+ +C W C
Sbjct: 3240 SCGKPESPEHGFVVGSKYTFE--STIIYQCEPGYELEGN-RERVCQENRQWSGGVAICKE 3296
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPII 141
C NG + +SCN G+ L G A CTE G WS +P+C P
Sbjct: 3297 TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP 3356
Query: 142 CPPP-SIPTFATLRVYKPSAGNNSLYRDTAV-FECLPQHAMFGNDTITCTTHGNWTKL-P 198
CP P IP A L Y D V +C + G+ ITC WT+
Sbjct: 3357 CPVPFVIPENALL-------SEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSA 3409
Query: 199 ECREVKCPFPSRPDNGFVNYPAKPTLY-YKDKATFGCHDGYSLDGPEEIECTKLGNWSAM 257
+C ++ C P+ +N A+ Y Y D T+ C+ GY L+G C + G W++
Sbjct: 3410 KCEKISCGPPAHVENAI----ARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSP 3465
Query: 258 PSCKASCKVPVKKATV 273
P C+A C+ P + +
Sbjct: 3466 PICRAVCRFPCQNGGI 3481
Score = 112 bits (280), Expect = 5e-25
Identities = 66/261 (25%), Positives = 114/261 (43%), Gaps = 25/261 (9%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYP 103
G + YSCKPG++ G + +C W + +C C + NG+++ + + Y
Sbjct: 2736 GSAVQYSCKPGHILAGSDLR-LCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYL 2794
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
+T+ + C+ G+ LNG + C ++ W + P+C P+ C P + +R G+
Sbjct: 2795 STLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVR------GDE 2848
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKP 222
++ + C + G + C +G+W+ P+C V+C P + NG
Sbjct: 2849 YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTE---GL 2905
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKASCKVPVKKATVVYQGERVK 281
+ + TF CH+GY L G ++ C GNW A +P CK V G
Sbjct: 2906 DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKP-----------VNCGPPED 2954
Query: 282 IQEKFKNG--MLHGDKVSFFC 300
+ F NG +HG + + C
Sbjct: 2955 LAHGFPNGFSFIHGGHIQYQC 2975
Score = 108 bits (269), Expect = 9e-24
Identities = 76/256 (29%), Positives = 103/256 (40%), Gaps = 27/256 (10%)
Query: 22 TCPKPD-----DLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINT 76
+C KP+ + S L T Y Y C PGYV G R+ C W +
Sbjct: 2774 SCKKPNPVMNGSIKGSNYTYLSTLY-------YECDPGYVLNGTERR-TCQDDKNWDEDE 2825
Query: 77 LKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPV 136
C P C + NG VR + + I ++CN GF L GA S C G WS P
Sbjct: 2826 PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885
Query: 137 CAPIIC-PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNW- 194
C P+ C PP + T G + + F C + + G +TC + GNW
Sbjct: 2886 CVPVRCATPPQLANGVT-------EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938
Query: 195 TKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW 254
++P C+ V C P +GF P + + + C GY L G C G+W
Sbjct: 2939 AEIPLCKPVNCGPPEDLAHGF---PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSW 2995
Query: 255 S-AMPSC-KASCKVPV 268
S + PSC C PV
Sbjct: 2996 SGSSPSCLPCRCSTPV 3011
Score = 107 bits (268), Expect = 1e-23
Identities = 70/237 (29%), Positives = 101/237 (42%), Gaps = 13/237 (5%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYP 103
G ++Y+C PGY G IC G W + C C ENG +R+T
Sbjct: 2678 GTMVSYTCNPGYELLGNP-VLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMG 2736
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
+ + +SC G L G+D C E KWS P C I C P+ +++ G+N
Sbjct: 2737 SAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIK------GSN 2790
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK-LPECREVKCPFPSRPDNGFVNYPAKP 222
Y T +EC P + + G + TC NW + P C V C P NG V
Sbjct: 2791 YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVR---GD 2847
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSC-KASCKVPVKKATVVYQG 277
++ + + C++G+ L+G C G+WS A P C C P + A V +G
Sbjct: 2848 EYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEG 2904
Score = 102 bits (254), Expect = 5e-22
Identities = 67/224 (29%), Positives = 102/224 (45%), Gaps = 16/224 (7%)
Query: 45 EEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPN 104
+EI Y+C G++ G R +C G W T C P C L NG + +
Sbjct: 2853 KEIEYTCNEGFLLEGA-RSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMK 2911
Query: 105 TISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNS 164
++F C+ G+ L+GA C +G W E+P+C P+ C PP L P+ G +
Sbjct: 2912 EVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPE-----DLAHGFPN-GFSF 2965
Query: 165 LYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKPT 223
++ ++C P + + GN + C ++G+W+ P C +C P + G VN T
Sbjct: 2966 IHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPV-IEYGTVN----GT 3020
Query: 224 LYYKDKAT-FGCHDGYSLDGPEEIECTKLGNWSA-MPSCK-ASC 264
+ KA C G+ L G EI C G WS+ P C+ SC
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC 3064
Score = 101 bits (251), Expect = 1e-21
Identities = 66/230 (28%), Positives = 97/230 (42%), Gaps = 13/230 (5%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTF 100
Y G E+T+SC+ GY G + K C +G W C C I ENG + F
Sbjct: 1805 YTVGAEVTFSCQEGYQLMG-VTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAF 1863
Query: 101 EYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSA 160
+ + +++ CN G+ L G + C WS PVC P+ C P +
Sbjct: 1864 TFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYIL----- 1918
Query: 161 GNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PECREVKCPFPSRPDNGFVNYP 219
+ Y TA + C +++ G I CT G W + P C V C P + +
Sbjct: 1919 -SGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVI--- 1974
Query: 220 AKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKA-SCKVP 267
+++ T+ C +GY+L G + IEC G WS + C A SC P
Sbjct: 1975 TGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEP 2024
Score = 95.5 bits (236), Expect = 6e-20
Identities = 64/254 (25%), Positives = 108/254 (42%), Gaps = 19/254 (7%)
Query: 23 CPKPDDLPFSTVVPL-KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPIN--TLKC 79
C KP + +S + + K + G +++ C G+V K C G W + +++C
Sbjct: 2083 CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSA-KIECMRGGQWNPSPMSIQC 2141
Query: 80 TPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAP 139
P C + NG + + + +++SCN GFY+ G + C G+WS +P C P
Sbjct: 2142 IPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHP 2201
Query: 140 IIC-PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNW-TKL 197
+ C PP + + + G ++ ++C P + G+ C + +W ++
Sbjct: 2202 VSCGEPPKVEN----GFLEHTTGR--IFESEVRYQCNPGYKSVGSPVFVCQANRHWHSES 2255
Query: 198 P-ECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS- 255
P C + C P NGF+ K F C++GY L G C K G W+
Sbjct: 2256 PLMCVPLDCGKPPPIQNGFMK---GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNK 2312
Query: 256 -AMPSC-KASCKVP 267
+ P C A C P
Sbjct: 2313 KSNPKCMPAKCPEP 2326
Score = 95.1 bits (235), Expect = 8e-20
Identities = 66/228 (28%), Positives = 93/228 (40%), Gaps = 19/228 (8%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTF 100
Y G + YSC G+ +G +K C TG W C P C +ENG + +TT
Sbjct: 2162 YSFGAMVAYSCNKGFYIKGE-KKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG 2220
Query: 101 E-YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPV-CAPIIC--PPPSIPTFATLRVY 156
+ + + + CN G+ G+ C W E P+ C P+ C PPP F
Sbjct: 2221 RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMK---- 2276
Query: 157 KPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL--PECREVKCPFPSRPDNG 214
G N F C + + G+ + TC G W K P+C KCP P +N
Sbjct: 2277 ----GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQ 2332
Query: 215 FVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCK 261
V K TF C +G+ L GP ++C W+ + P CK
Sbjct: 2333 LV---LKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK 2377
Score = 94.4 bits (233), Expect = 1e-19
Identities = 69/260 (26%), Positives = 94/260 (36%), Gaps = 53/260 (20%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCT----------------------- 80
G +TY C GY G R F C G W + C
Sbjct: 1709 GSTVTYQCNNGYYLLGDSRMF-CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGS 1767
Query: 81 ------------------PRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSA 122
P C G ENG + ++FSC G+ L G
Sbjct: 1768 YICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKI 1827
Query: 123 KCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFG 182
C E G+W+ +P C + C P+IP + + G+ YR C + + G
Sbjct: 1828 TCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYR------CNKGYTLAG 1881
Query: 183 NDTITCTTHGNWTKLPE-CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLD 241
+ +C + +W+ P C VKC P +NG L Y A++ C GYSL
Sbjct: 1882 DKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG---LTYLSTASYSCDTGYSLQ 1938
Query: 242 GPEEIECTKLGNWS-AMPSC 260
GP IECT G W A P+C
Sbjct: 1939 GPSIIECTASGIWDRAPPAC 1958
Score = 91.3 bits (225), Expect = 1e-18
Identities = 54/216 (25%), Positives = 89/216 (41%), Gaps = 12/216 (5%)
Query: 48 TYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTIS 107
+YSC GY S G C +G+W C C +++ + F + NT++
Sbjct: 1928 SYSCDTGY-SLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVT 1986
Query: 108 FSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYR 167
++C G+ L G D+ +C +GKWS C + C P I A+ P + L+
Sbjct: 1987 YTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHAS-----PETAHR-LFG 2040
Query: 168 DTAVFECLPQHAMFGNDTITCTTHGNWT-----KLPECREVKCPFPSRPDNGFVNYPAKP 222
D A + C +++ N + C G W +P C C P + +K
Sbjct: 2041 DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA 2100
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258
+F C +G+ L+ +IEC + G W+ P
Sbjct: 2101 KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSP 2136
Score = 90.1 bits (222), Expect = 3e-18
Identities = 59/203 (29%), Positives = 85/203 (41%), Gaps = 18/203 (8%)
Query: 91 ENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTF 150
E+ A + F Y +S++CN G+ L G C E+G W+ P C I C P+ P
Sbjct: 2666 ESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPEN 2725
Query: 151 ATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPS 209
LR + S G+ + C P H + G+D C + W+ P C + C P+
Sbjct: 2726 GFLRFTETSMGS------AVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPN 2779
Query: 210 RPDNGFV---NYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSC-KASC 264
NG + NY TLYY+ C GY L+G E C NW P C C
Sbjct: 2780 PVMNGSIKGSNYTYLSTLYYE------CDPGYVLNGTERRTCQDDKNWDEDEPICIPVDC 2833
Query: 265 KVPVKKATVVYQGERVKIQEKFK 287
P A +G+ Q++ +
Sbjct: 2834 SSPPVSANGQVRGDEYTFQKEIE 2856
Score = 89.7 bits (221), Expect = 3e-18
Identities = 73/295 (24%), Positives = 109/295 (36%), Gaps = 48/295 (16%)
Query: 42 EPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFE 101
+PG ++ C PG+ G ++ C G W C C LENG F
Sbjct: 1649 KPGSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFY 1707
Query: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI--------------------- 140
+T+++ CN G+YL G CT+ G W+ P C +
Sbjct: 1708 AGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGS 1767
Query: 141 ---ICPPP-------SIPTFATLRVYKPSAGNNS--LYRDTA--VFECLPQHAMFGNDTI 186
C PP P G++S +Y A F C + + G I
Sbjct: 1768 YICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKI 1827
Query: 187 TCTTHGNWTKL-PECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEE 245
TC G W L P C+ V C P+ P+NG + A + K T+ C+ GY+L G +E
Sbjct: 1828 TCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELA---FTFGSKVTYRCNKGYTLAGDKE 1884
Query: 246 IECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC 300
C +WS P PV + E + + +G+ + S+ C
Sbjct: 1885 SSCLANSSWSHSP--------PVCEPVKCSSPENINNGKYILSGLTYLSTASYSC 1931
Score = 87.8 bits (216), Expect = 1e-17
Identities = 67/275 (24%), Positives = 108/275 (39%), Gaps = 19/275 (6%)
Query: 39 TFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYT 98
T ++ G+ C G+ G + + C G W C C ++ N + T
Sbjct: 3020 TDFDCGKAARIQCFKGFKLLG-LSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISET 3078
Query: 99 TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIIC-PPPSIPTFATLRVYK 157
+ N I++SC +G+ + G+ CTE+G WS PVC P+ C PPS+
Sbjct: 3079 SSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAV------ 3132
Query: 158 PSAGNNSLYRDTAVFECLPQHAM-FGNDTITCTTHGNWTKLPE---CREVKCPFPSRPDN 213
+ G Y CL + M DT TC G W PE C KCP P +
Sbjct: 3133 -ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW--FPERISCSPKKCPLPENITH 3189
Query: 214 GFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATV 273
V+ + + C +GY+ +G C G W S ++ V K
Sbjct: 3190 ILVH---GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPES 3246
Query: 274 VYQGERVKIQEKFKNGMLHGDKVSFFCK-NKEKKC 307
G V + F++ +++ + + + N+E+ C
Sbjct: 3247 PEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC 3281
Score = 87.8 bits (216), Expect = 1e-17
Identities = 65/291 (22%), Positives = 118/291 (40%), Gaps = 28/291 (9%)
Query: 16 VAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW--P 73
++ + + CP P+++ + ++ + +++ SC GY G + +C L G W P
Sbjct: 3174 ISCSPKKCPLPENI--THILVHGDDFSVNRQVSVSCAEGYTFEG-VNISVCQLDGTWEPP 3230
Query: 74 INTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPE 133
+ C+P C E+G V + + + +TI + C G+ L G C E +WS
Sbjct: 3231 FSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGG 3290
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGN 193
+ +C C P + + G N V+ C +++ G CT +G
Sbjct: 3291 VAICKETRCETPLEFLNGKADIENRTTGPN------VVYSCNRGYSLEGPSEAHCTENGT 3344
Query: 194 WT-KLPECREVKCPFP-SRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKL 251
W+ +P C+ CP P P+N + ++ Y + C +G+ L G I C
Sbjct: 3345 WSHPVPLCKPNPCPVPFVIPENALL---SEKEFYVDQNVSIKCREGFLLQGHGIITCNPD 3401
Query: 252 GNWS-AMPSC-KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC 300
W+ C K SC P + +G + +GD +++ C
Sbjct: 3402 ETWTQTSAKCEKISCGPPAHVENAIARGVHYQ----------YGDMITYSC 3442
Score = 85.5 bits (210), Expect = 6e-17
Identities = 70/292 (23%), Positives = 102/292 (34%), Gaps = 58/292 (19%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPR 82
CP+P+++P + Y Y+CKPG+ G +C G W C
Sbjct: 2440 CPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGNTTT-LCGENGHWLGGKPTCKAI 2496
Query: 83 VCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIIC 142
C + NG YT Y T+++SCN GF L G + C E G W + P C I C
Sbjct: 2497 ECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHC 2556
Query: 143 --PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPEC 200
P P F G + Y ++ C P + G+ TC G + +P C
Sbjct: 2557 DSPQPIENGFV--------EGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTC 2608
Query: 201 REVKCPFPSRPDNG--------------------------------------FVNYPAKP 222
+ C P D G + N P
Sbjct: 2609 MPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESP 2668
Query: 223 TLY-----YKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSC-KASCKVP 267
+ Y ++ C+ GY L G + C + G W+ + PSC C +P
Sbjct: 2669 ATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLP 2720
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/163 (24%), Positives = 64/163 (39%), Gaps = 10/163 (6%)
Query: 51 CKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFE--YPNTISF 108
C PG+ G +C GLW + C R CP ++G + +T E Y T
Sbjct: 406 CHPGF-DLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLV 464
Query: 109 SCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRD 168
+C+ G+ L G+D C +W P C C +P + + + G
Sbjct: 465 ACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH--NCGKQPAKFG 522
Query: 169 TAVF-ECLPQHAMFG-NDTITCTTHGNW---TKLPECREVKCP 206
T + C + G + + CTT G W + C++V+ P
Sbjct: 523 TICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAP 565
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/202 (23%), Positives = 78/202 (38%), Gaps = 32/202 (15%)
Query: 163 NSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-CREVKCPFPSRPDNGFVNYPAK 221
N+ + C P + G+ I C +G W+ CR CP +P +G ++ +
Sbjct: 395 NNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTR 454
Query: 222 PTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSC-KASC--------------- 264
LY K C +GY L+G +++ C W P C + C
Sbjct: 455 EMLY-KTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHN 513
Query: 265 --KVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEV 322
K P K T+ Y V ++ F +L G K C K + A C D +E
Sbjct: 514 CGKQPAKFGTICY----VSCRQGF---ILSGVKEMLRCTTSGKWNVGVQAAVCKD--VEA 564
Query: 323 PK--CFKEHSSLAFWKTDASDV 342
P+ C K+ + + D+++V
Sbjct: 565 PQINCPKDIEAKTLEQQDSANV 586
Score = 31.6 bits (70), Expect = 1.1
Identities = 22/62 (35%), Positives = 25/62 (40%), Gaps = 5/62 (8%)
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFG--CHDGYSLDGPEEIECTKLGNWSAM 257
C V CP P+NG Y + T A G CH G+ L G I C G WS
Sbjct: 373 CELVHCPALKPPENG---YFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGS 429
Query: 258 PS 259
S
Sbjct: 430 ES 431
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 113 bits (282), Expect = 3e-25
Identities = 82/259 (31%), Positives = 122/259 (47%), Gaps = 24/259 (9%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMR-KFICPLTGLWPINTLKCT 80
TC P+ + KTF + +++ Y C GY + GG + + + LT W + T KCT
Sbjct: 152 TCLAPELYNGNYSTTQKTF-KVKDKVQYECATGYYTAGGKKTEEVECLTYGWSL-TPKCT 209
Query: 81 PRVCPFAGILENGAVRYT--TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCA 138
C ++ENG T+E + + F C+ +YL+G+D +C G W PE PVC
Sbjct: 210 KLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCE 268
Query: 139 PII--CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK 196
CPPP +P + ++ + + + + EC + G+ I C G WT+
Sbjct: 269 GRRNRCPPPPLPINSKIQTHSTTYRHGEIVH----IECELNFEIHGSAEIRCED-GKWTE 323
Query: 197 LPECRE----VKCPFPSRPDNGFVNYPAKPTLYYK-DKATFGCHDGYSLDGPEEIECTKL 251
P+C E V C P +NG N +K +YY DK T+ C GY L G EI C +
Sbjct: 324 PPKCIEGQEKVACEEPPFIENGAANLHSK--IYYNGDKVTYACKSGYLLHGSNEITCNR- 380
Query: 252 GNWSAMPSC---KASCKVP 267
G W+ P C +CK P
Sbjct: 381 GKWTLPPECVENNENCKHP 399
Score = 92.4 bits (228), Expect = 5e-19
Identities = 76/311 (24%), Positives = 123/311 (39%), Gaps = 32/311 (10%)
Query: 36 PLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL------KCTPRVCPFAGI 89
P+K YE G+ + + C Y G C G +P + + +C P P
Sbjct: 226 PVKQTYEEGDVVQFFCHENYYLSGS-DLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSK 284
Query: 90 LENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAP----IICPPP 145
++ + TT+ + + C F ++G+ +C E+GKW+ E P C + C P
Sbjct: 285 IQTHS---TTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEEP 339
Query: 146 SIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECRE--V 203
++ N D + C + + G++ ITC G WT PEC E
Sbjct: 340 PFIENGAANLHSKIYYNG----DKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNE 394
Query: 204 KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKAS 263
C P NG V + + C++ Y L G + C + G WS+ P C
Sbjct: 395 NCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-GKWSSPPVCLEP 453
Query: 264 CKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTE----DAQCIDGT 319
C V V ++++ K++ +LHGD + F CK T QC G
Sbjct: 454 CTVNVD----YMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGE 509
Query: 320 IEVPKCFKEHS 330
++ P C ++ S
Sbjct: 510 VKYPLCTRKES 520
Score = 66.6 bits (161), Expect = 3e-11
Identities = 74/324 (22%), Positives = 128/324 (39%), Gaps = 52/324 (16%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRV--CPFAGILENGAVR-- 96
Y G+++TY+CK GY+ G + C G W + +C C ++ NGAV
Sbjct: 354 YYNGDKVTYACKSGYLLHGS-NEITCN-RGKWTLPP-ECVENNENCKHPPVVMNGAVADG 410
Query: 97 -YTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRV 155
++ +++ + CN + L G+ ++C E+GKWS +P +C P T+ V
Sbjct: 411 ILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWS------SPPVCLEP-----CTVNV 458
Query: 156 YKPSAGN---------NSLYRDTAVFECLPQHAM-----FGNDTITCTTHGNWTKLPEC- 200
+ N L+ D F C + + ++ C K P C
Sbjct: 459 DYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNR--GEVKYPLCT 516
Query: 201 -REVK--CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM 257
+E K C P +G + T + C D + L+G E C G W+
Sbjct: 517 RKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-GMWTTP 575
Query: 258 PSCKASCKVPVKKATVVYQGERVKIQEKFKNG--MLHGDKVSFFCKNKEKKCS-YTEDA- 313
P C C + + + + ++ F N +LHG+ + F C+ Y +
Sbjct: 576 PLCLEPCTLSFTEM----EKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSI 631
Query: 314 ---QCIDGTIEVPKCFKEHSSLAF 334
QC G ++ P+C S+L++
Sbjct: 632 LRMQCDRGQLKYPRCIPRQSTLSY 655
Score = 66.2 bits (160), Expect = 4e-11
Identities = 78/319 (24%), Positives = 127/319 (39%), Gaps = 61/319 (19%)
Query: 38 KTFYEP---GEEITYSCKPGYVSRGGMRK--FICPLTGLWPINTL--KCTPRVCPFAGIL 90
K+FY P +++++ C GY + G ++ C G P KCT L
Sbjct: 43 KSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPD------L 96
Query: 91 ENGAVRYTTFEYP--NTISFSCNTGFYLNGA---DSAKCTEEGKWSPELPVCAPI--ICP 143
NG + Y + + C +G+ G + +C +G WS + P C C
Sbjct: 97 SNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCL 154
Query: 144 PPSIPT---FATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGN---DTITCTTHGNWTKL 197
P + T + +K +D +EC + G + + C T+G W+
Sbjct: 155 APELYNGNYSTTQKTFK--------VKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT 205
Query: 198 PECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM 257
P+C ++KC +NG+ +P K T D F CH+ Y L G + I+C G +
Sbjct: 206 PKCTKLKCSSLRLIENGYF-HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPES 264
Query: 258 PSCKA---SCKVP--------VKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKK 306
P C+ C P +T GE V I+ + N +HG + E +
Sbjct: 265 PVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECEL-NFEIHG--------SAEIR 315
Query: 307 C---SYTEDAQCIDGTIEV 322
C +TE +CI+G +V
Sbjct: 316 CEDGKWTEPPKCIEGQEKV 334
Score = 46.6 bits (109), Expect = 3e-05
Identities = 75/341 (21%), Positives = 127/341 (37%), Gaps = 41/341 (12%)
Query: 23 CPKPDDLPFSTVVPL-KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW--PINTLKC 79
CP P LP ++ + T Y GE + C+ + G I G W P ++
Sbjct: 274 CPPPP-LPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAE--IRCEDGKWTEPPKCIEG 330
Query: 80 TPRV-CPFAGILENGAVRYTTFEYPN--TISFSCNTGFYLNGADSAKCTEEGKWS--PEL 134
+V C +ENGA + Y N ++++C +G+ L+G++ C GKW+ PE
Sbjct: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-GKWTLPPEC 389
Query: 135 PVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNW 194
PP + A S S + + C + + G+ C G W
Sbjct: 390 VENNENCKHPPVVMNGAVADGILASYATGS----SVEYRCNEYYLLRGSKISRCE-QGKW 444
Query: 195 TKLPECRE---VKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLD-----GPEEI 246
+ P C E V + +R +N + + + + + D F C GY L +
Sbjct: 445 SSPPVCLEPCTVNVDYMNR-NNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
Query: 247 ECTKLGNWSAMPSC-----KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCK 301
+C + P C K C P V V E +G V + C
Sbjct: 504 QCNR--GEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYE-------NGSSVEYRCF 554
Query: 302 NKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDV 342
+ + +A C+DG P E +L+F + + +++
Sbjct: 555 DHHF-LEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNL 594
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 109 bits (273), Expect = 3e-24
Identities = 78/259 (30%), Positives = 110/259 (42%), Gaps = 28/259 (10%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SCKASCKVPVKKATVVYQG 277
C + K Y G
Sbjct: 282 KCLKGPRPTYKPPVSNYPG 300
Score = 70.9 bits (172), Expect = 2e-12
Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRPDNGFVNYP 219
+ W +P+C + P P + + YP
Sbjct: 273 NSTWDPPVPKCLKGPRPTYKPPVSNYPGYP 302
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 109 bits (273), Expect = 3e-24
Identities = 78/259 (30%), Positives = 110/259 (42%), Gaps = 28/259 (10%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SCKASCKVPVKKATVVYQG 277
C + K Y G
Sbjct: 282 KCLKGPRPTYKPPVSNYPG 300
Score = 70.9 bits (172), Expect = 2e-12
Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRPDNGFVNYP 219
+ W +P+C + P P + + YP
Sbjct: 273 NSTWDPPVPKCLKGPRPTYKPPVSNYPGYP 302
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 109 bits (273), Expect = 3e-24
Identities = 78/259 (30%), Positives = 110/259 (42%), Gaps = 28/259 (10%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SCKASCKVPVKKATVVYQG 277
C + K Y G
Sbjct: 282 KCLKGPRPTYKPPVSNYPG 300
Score = 70.9 bits (172), Expect = 2e-12
Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 17/210 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRPDNGFVNYP 219
+ W +P+C + P P + + YP
Sbjct: 273 NSTWDPPVPKCLKGPRPTYKPPVSNYPGYP 302
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 109 bits (272), Expect = 4e-24
Identities = 80/262 (30%), Positives = 111/262 (42%), Gaps = 29/262 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC-KASCKVPVKKATVVYQGER 279
C K S K G R
Sbjct: 282 KCLKVSTSSTTKSPASSASGPR 303
Score = 67.4 bits (163), Expect = 2e-11
Identities = 51/194 (26%), Positives = 81/194 (41%), Gaps = 17/194 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREV 203
+ W +P+C +V
Sbjct: 273 NSTWDPPVPKCLKV 286
Score = 54.3 bits (129), Expect = 2e-07
Identities = 37/133 (27%), Positives = 52/133 (39%), Gaps = 12/133 (9%)
Query: 41 YEPGEEITYSCKPGY----VSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR 96
+E + +TYSC P S G C +W +C C F ++ENG
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP-VVENGKQI 239
Query: 97 Y---TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI----ICPPPSIPT 149
F Y T+ F C+ GFYL+G+D+ C W P +P C + P+
Sbjct: 240 SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSA 299
Query: 150 FATLRVYKPSAGN 162
YKP N
Sbjct: 300 SGPRPTYKPPVSN 312
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 109 bits (272), Expect = 4e-24
Identities = 80/262 (30%), Positives = 111/262 (42%), Gaps = 29/262 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC-KASCKVPVKKATVVYQGER 279
C K S K G R
Sbjct: 282 KCLKVSTSSTTKSPASSASGPR 303
Score = 67.4 bits (163), Expect = 2e-11
Identities = 51/194 (26%), Positives = 81/194 (41%), Gaps = 17/194 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREV 203
+ W +P+C +V
Sbjct: 273 NSTWDPPVPKCLKV 286
Score = 54.3 bits (129), Expect = 2e-07
Identities = 37/133 (27%), Positives = 52/133 (39%), Gaps = 12/133 (9%)
Query: 41 YEPGEEITYSCKPGY----VSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR 96
+E + +TYSC P S G C +W +C C F ++ENG
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP-VVENGKQI 239
Query: 97 Y---TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI----ICPPPSIPT 149
F Y T+ F C+ GFYL+G+D+ C W P +P C + P+
Sbjct: 240 SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSA 299
Query: 150 FATLRVYKPSAGN 162
YKP N
Sbjct: 300 SGPRPTYKPPVSN 312
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 109 bits (272), Expect = 4e-24
Identities = 80/262 (30%), Positives = 111/262 (42%), Gaps = 29/262 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC-KASCKVPVKKATVVYQGER 279
C K S K G R
Sbjct: 282 KCLKVSTSSTTKSPASSASGPR 303
Score = 67.4 bits (163), Expect = 2e-11
Identities = 51/194 (26%), Positives = 81/194 (41%), Gaps = 17/194 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREV 203
+ W +P+C +V
Sbjct: 273 NSTWDPPVPKCLKV 286
Score = 54.3 bits (129), Expect = 2e-07
Identities = 37/133 (27%), Positives = 52/133 (39%), Gaps = 12/133 (9%)
Query: 41 YEPGEEITYSCKPGY----VSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR 96
+E + +TYSC P S G C +W +C C F ++ENG
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP-VVENGKQI 239
Query: 97 Y---TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI----ICPPPSIPT 149
F Y T+ F C+ GFYL+G+D+ C W P +P C + P+
Sbjct: 240 SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSA 299
Query: 150 FATLRVYKPSAGN 162
YKP N
Sbjct: 300 SGPRPTYKPPVSN 312
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 66.2 bits (160), Expect = 4e-11
Identities = 50/191 (26%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPEC 200
+ W +P+C
Sbjct: 273 NSTWDPPVPKC 283
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 68.2 bits (165), Expect = 1e-11
Identities = 54/211 (25%), Positives = 87/211 (41%), Gaps = 18/211 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSR-PDNGFVNYP 219
+ W +P+C +V ++ P + YP
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 68.2 bits (165), Expect = 1e-11
Identities = 54/211 (25%), Positives = 87/211 (41%), Gaps = 18/211 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSR-PDNGFVNYP 219
+ W +P+C +V ++ P + YP
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 17/202 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRP 211
+ W +P+C +V P ++P
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKP 294
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 17/202 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRP 211
+ W +P+C +V P ++P
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKP 294
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 66.2 bits (160), Expect = 4e-11
Identities = 50/191 (26%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPEC 200
+ W +P+C
Sbjct: 273 NSTWDPPVPKC 283
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 17/202 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRP 211
+ W +P+C +V P ++P
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKP 294
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 108 bits (271), Expect = 5e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
Query: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
Query: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 259 SC 260
C
Sbjct: 282 KC 283
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 17/202 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
Query: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
Query: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 191 HGNW-TKLPECREVKCPFPSRP 211
+ W +P+C +V P ++P
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKP 294
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 106 bits (265), Expect = 3e-23
Identities = 77/265 (29%), Positives = 106/265 (40%), Gaps = 20/265 (7%)
Query: 42 EPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRV--CPFAGILENGAVRYTT 99
E G ++ SC PGY G R C G W I + + RV C NG T
Sbjct: 2580 EYGAQVLLSCSPGYYLEG-WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTL 2638
Query: 100 FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
Y T F+CNTG+ L G+ +C G WS C C P P V
Sbjct: 2639 TVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPD-PI-----VNGHI 2692
Query: 160 AGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNY 218
+G+ YRDT V++C P + G C W+ + P C + C P P +GF N
Sbjct: 2693 SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTN- 2751
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCK-ASCKVPVKKATVVYQ 276
D F C+ GY L G +C G WS+ +P+C+ +C P +
Sbjct: 2752 --GSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRH 2809
Query: 277 GERVKIQEKFKNGMLHGDKVSFFCK 301
G Q+ F +G + + CK
Sbjct: 2810 G-----QQNFPESFEYGMSILYHCK 2829
Score = 103 bits (258), Expect = 2e-22
Identities = 61/218 (27%), Positives = 99/218 (45%), Gaps = 14/218 (6%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTI 106
+ Y+C GY + G M + C G W CT C G L NG T F + T+
Sbjct: 3002 VIYACWEGYKTSGLMTRH-CTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTV 3060
Query: 107 SFSCNTGFYLNGADSA--KCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNS 164
S+ CN G+ + SA +CT++G+W+P PVC ++CP P T+ G++
Sbjct: 3061 SYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVE------GSDF 3114
Query: 165 LYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKPT 223
+ + + C+ + + + ++C G W ++P+C V C P P G + + +
Sbjct: 3115 RWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRL---SGKS 3171
Query: 224 LYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSC 260
YK + F C + L G C G WS + P+C
Sbjct: 3172 FTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTC 3209
Score = 103 bits (257), Expect = 2e-22
Identities = 71/242 (29%), Positives = 99/242 (40%), Gaps = 16/242 (6%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYP 103
G ++C GY G + C GLW + +C C + NG + F Y
Sbjct: 2642 GATAIFTCNTGYTLVGSHVRE-CLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYR 2700
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
+T+ + CN GF L G C ++ KWS + PVC PI C P P + G+
Sbjct: 2701 DTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGF------TNGSE 2754
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK-LPECREVKCPFPSRPDN----GFVNY 218
D F C + + G C ++G W+ LP CR V C P +N G N+
Sbjct: 2755 FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNF 2814
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKA-SCKVPVKKATVVYQ 276
P + Y + C G+ L G + C G W ++P C A SC P A V
Sbjct: 2815 P--ESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT 2872
Query: 277 GE 278
GE
Sbjct: 2873 GE 2874
Score = 100 bits (249), Expect = 2e-21
Identities = 64/245 (26%), Positives = 100/245 (40%), Gaps = 23/245 (9%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFI-CPLTGLWPINTLKCT 80
+C P L + + T + + ++Y C PGYV I C G W + C
Sbjct: 3037 SCGDPGTL--ANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCK 3094
Query: 81 PRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI 140
+CP ++NG V + F + ++IS+SC G+ L+ + C G W E+P C P+
Sbjct: 3095 AVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPV 3154
Query: 141 ICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PE 199
C P IP L +G + Y+ F+C + G+ C G W+ + P
Sbjct: 3155 FCGDPGIPAEGRL------SGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPT 3208
Query: 200 CREV---KCPFPSRPDNGFVN----YPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLG 252
C + CP P P G N Y T++++ C GY + G C
Sbjct: 3209 CIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFR------CRKGYHIQGSTTRTCLANL 3262
Query: 253 NWSAM 257
WS +
Sbjct: 3263 TWSGI 3267
Score = 100 bits (248), Expect = 2e-21
Identities = 66/233 (28%), Positives = 91/233 (39%), Gaps = 15/233 (6%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTF 100
+E G I Y CK G+ G C GLW + KC C G+ N + F
Sbjct: 2818 FEYGMSILYHCKKGFYLLGSSA-LTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELF 2876
Query: 101 EYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCA---PIICPPPSIPTFATLRVYK 157
Y + +SC L G D+ C E+ WS LP C P C P P +
Sbjct: 2877 TYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGS----- 2931
Query: 158 PSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PECREVKCPFPSRPDNGFV 216
G++ + F C H + G+ TC +G+W+ L P C V C P P NG +
Sbjct: 2932 -RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMI 2990
Query: 217 NYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCK-ASCKVP 267
+ + + + C +GY G CT G W+ P C SC P
Sbjct: 2991 --VSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDP 3041
Score = 81.3 bits (199), Expect = 1e-15
Identities = 63/223 (28%), Positives = 92/223 (41%), Gaps = 16/223 (7%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGL----WPINTLKCTPRVCPFAGILENGAVRYTT 99
G ++ Y CKPGY G C L W T C C NG+
Sbjct: 2453 GSKVHYFCKPGY-RMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNE 2511
Query: 100 FEYPNTISFSCNTGFYLNGAD--SAKCTEEGKWS--PELPVCAPIICPPPSIPTFATLRV 155
F + + + C+ GF L + +A C E+G WS + P C P+ CP + +
Sbjct: 2512 FTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHV-I 2570
Query: 156 YKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT---KLPECREVKCPFPSRPD 212
++ +G+ + Y + C P + + G + C +G W + P CR + C S P
Sbjct: 2571 WRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPP 2630
Query: 213 NGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS 255
NG N T+ Y A F C+ GY+L G EC G WS
Sbjct: 2631 NG--NKIGTLTV-YGATAIFTCNTGYTLVGSHVRECLANGLWS 2670
Score = 58.2 bits (139), Expect = 1e-08
Identities = 54/189 (28%), Positives = 76/189 (40%), Gaps = 26/189 (13%)
Query: 46 EITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP---RVCPFAGILENGAVRYTT-FE 101
E+ + CK ++ G R+ +C G W C CP G G + +E
Sbjct: 3177 EVFFQCKSPFILVGSSRR-VCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYE 3235
Query: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLR-VYKPSA 160
+T+ F C G+++ G+ + C WS C P C P P A +R + P+
Sbjct: 3236 VGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTF 3295
Query: 161 GNNSLYRDTAVFECLPQHAMF-GNDTITCTTHGNWT-KLPEC-----REV-----KCPFP 208
G T V+ C P + G++ TC WT K P C REV K P P
Sbjct: 3296 GY------TLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVP 3349
Query: 209 SRPDNGFVN 217
S D FVN
Sbjct: 3350 S--DVFFVN 3356
Score = 42.7 bits (99), Expect = 5e-04
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 13/98 (13%)
Query: 174 CLPQHAMFGNDTITCTTHG----NWTKL-PECREVKCPFPSRPDNGFVNYPAKPTLYYKD 228
C P + M G+ TC + W L P C+ V C P P NG
Sbjct: 2460 CKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSF---TGNEFTLDS 2516
Query: 229 KATFGCHDGYSLDGPEEIE--CTKLGNWS---AMPSCK 261
K + CH+G+ L+ ++ C + G WS P+CK
Sbjct: 2517 KVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCK 2554
Score = 38.1 bits (87), Expect = 0.012
Identities = 25/85 (29%), Positives = 33/85 (38%), Gaps = 8/85 (9%)
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC 200
C P IP Y G++ L+ DT FEC + G ITC + W+ P C
Sbjct: 528 CGDPGIPA------YGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Query: 201 REVKCPFPSRPDNGFVNYPAKPTLY 225
C F +G + P P Y
Sbjct: 582 -VFSCFFNFTASSGIILSPNYPEEY 605
Score = 36.6 bits (83), Expect = 0.034
Identities = 56/281 (19%), Positives = 97/281 (34%), Gaps = 67/281 (23%)
Query: 13 LCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW 72
L + A + CP P PF + + Y G+ +++ C PGY+ G
Sbjct: 2078 LAYQAYELQNCPDPP--PFQNGYMINSDYSVGQSVSFECYPGYILIG------------H 2123
Query: 73 PINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSP 132
P+ T ++G R + +P C+ N +
Sbjct: 2124 PVLT-------------CQHGINRNWNYPFPR-----CDAPCGYNVTSQNGTIYSPGFPD 2165
Query: 133 ELPV---CAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCT 189
E P+ C +I PP + + + A N+ + + PQ +F +T T
Sbjct: 2166 EYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALET 2225
Query: 190 THGNWTKLPECREVKCPFPSRPDNG---FVNY-----------PAKP---------TLYY 226
+ + +V F S NG +N+ PA P
Sbjct: 2226 AYSS------TNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDDDFEI 2279
Query: 227 KDKATFGCHDGYSLDGPEEIEC---TKLGNWSAMPSCKASC 264
D + CH GY+L G + + C ++L ++P+C+A C
Sbjct: 2280 GDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQC 2320
Score = 36.2 bits (82), Expect = 0.044
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 227 KDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKASC--KVPVKKATVVYQG 277
+ TF C GY+L E + C + W+ A+PSC A C + K TV+ G
Sbjct: 893 RSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPG 946
Score = 35.4 bits (80), Expect = 0.075
Identities = 19/45 (42%), Positives = 23/45 (51%), Gaps = 3/45 (6%)
Query: 228 DKATFGCHDGYSLDGPEEIECTKLGN--WSA-MPSCKASCKVPVK 269
D TF C GY L+G ++ C G WSA +P C A C VK
Sbjct: 1066 DSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVK 1110
Score = 35.4 bits (80), Expect = 0.075
Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 7/64 (10%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---WSA-MPSC 260
C P P NG ++ D TF C GY L G +I C +L N W P+C
Sbjct: 1392 CNDPGMPQNGTRYGDSREA---GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
Query: 261 KASC 264
A+C
Sbjct: 1449 IAAC 1452
Score = 35.0 bits (79), Expect = 0.098
Identities = 17/54 (31%), Positives = 26/54 (48%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
C GI NG F +T++FSC+ G+ L+ + C +W+ LP C
Sbjct: 874 CLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927
Score = 33.9 bits (76), Expect = 0.22
Identities = 16/57 (28%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVC 137
C G+ +NG + E +T++F C+ G+ L G C + W P+ P C
Sbjct: 1392 CNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
Score = 32.3 bits (72), Expect = 0.64
Identities = 16/54 (29%), Positives = 24/54 (44%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
C GI G ++F + +T++F C F L G C + +WS P C
Sbjct: 528 CGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 31.2 bits (69), Expect = 1.4
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 203 VKCPFPSRPDNGFVNYPAKPTLYYKDKAT-FGCHDGYSLDGPEEIECTKLGN--W-SAMP 258
VKC P P+ G Y + ++ D + C+ GY++ G + C W +P
Sbjct: 1216 VKCEDPGIPNYG---YRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLP 1272
Query: 259 SCKASCKVPVKKAT 272
SC A C + AT
Sbjct: 1273 SCIAECGGQIHAAT 1286
Score = 31.2 bits (69), Expect = 1.4
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAV-FECLPQHAMFGNDTITCTTHGN--WTK-L 197
C P IP + Y+ + + DT V + C P +AM G++T+TC + W K L
Sbjct: 1218 CEDPGIPNYG----YR--IRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPL 1271
Query: 198 PEC 200
P C
Sbjct: 1272 PSC 1274
Score = 30.4 bits (67), Expect = 2.4
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCT--EEGK--WSPELPVC 137
C G + NG T F+ +TI++ C++G+ + S C +GK W LP C
Sbjct: 1565 CFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 30.4 bits (67), Expect = 2.4
Identities = 22/92 (23%), Positives = 37/92 (40%), Gaps = 11/92 (11%)
Query: 143 PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT---KLPE 199
PPP++P L + ++ D ++C P + + G D +TC LP
Sbjct: 2261 PPPAVPQAEML-----TEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315
Query: 200 CREVKCPFPS--RPDNGFVNYPAKPTLYYKDK 229
C E +CP +G + P P Y+ +
Sbjct: 2316 C-EAQCPANEVRTGSSGVILSPGYPGNYFNSQ 2346
Score = 29.6 bits (65), Expect = 4.1
Identities = 20/63 (31%), Positives = 24/63 (38%), Gaps = 7/63 (11%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTK----LGNWS-AMPS 259
CP P P+NG F C D Y L G + I C + L WS P
Sbjct: 349 CPDPGIPENG--RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPI 406
Query: 260 CKA 262
C+A
Sbjct: 407 CRA 409
Score = 29.6 bits (65), Expect = 4.1
Identities = 15/38 (39%), Positives = 17/38 (44%), Gaps = 1/38 (2%)
Query: 228 DKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKASC 264
D TF C + L G I C + WS PSC SC
Sbjct: 548 DTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSC 585
Score = 28.5 bits (62), Expect = 9.2
Identities = 22/85 (25%), Positives = 32/85 (37%), Gaps = 8/85 (9%)
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC 200
C P IP V G + R T F C P + + ++ + C + W LP C
Sbjct: 874 CLDPGIP------VNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927
Query: 201 REVKCPFPSRPDNGFVNYPAKPTLY 225
+ C + +G V P P Y
Sbjct: 928 -DALCGGYIQGKSGTVLSPGFPDFY 951
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 105 bits (263), Expect = 5e-23
Identities = 73/249 (29%), Positives = 110/249 (44%), Gaps = 20/249 (8%)
Query: 23 CPKPDDLPFSTVVPL---KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
C P L F+ + + +T ++ G + Y+C PGYV + C G W NT C
Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF-C 108
Query: 80 TPRVCPFAGILENGAVRY-TTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELP 135
+ C G L NG V T + + I FSC+ GF+L G+ +++C + + WS LP
Sbjct: 109 IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP 168
Query: 136 VCAPIICPPPSIPTFATLRVYKPSAGNN-SLYRDTAVFECLPQHAMFGNDTITCT----T 190
C + C PP +R + S N Y + + C P+ ++ G+ +I+CT T
Sbjct: 169 QCEIVKCKPP-----PDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
Query: 191 HGNW-TKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT 249
G W P C ++ C P +G + P YKD F C G+ L G I C
Sbjct: 224 IGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD 282
Query: 250 KLGNWSAMP 258
W+ P
Sbjct: 283 ADSKWNPSP 291
Score = 86.3 bits (212), Expect = 4e-17
Identities = 79/305 (25%), Positives = 119/305 (39%), Gaps = 25/305 (8%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLT----GLWPINTLK 78
C P D+ + FY G +TYSC P + S G C + G+W +
Sbjct: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRF-SLLGHASISCTVENETIGVWRPSPPT 233
Query: 79 CTPRVCPFAGILENGAVRY--TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPV 136
C C + V + Y +TI F C GF L G+ C + KW+P P
Sbjct: 234 CEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPA 293
Query: 137 CAPIIC-PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGND--TITCTTHGN 193
C P C P IP + +P+ + + + C P + ++ T+ C +
Sbjct: 294 CEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLR 353
Query: 194 WTKLPECREVKCPFPSRPDNGFV-----NYPAKPTLY-YKDKATFGCHDGYSLDGPEEIE 247
WT C + CP P + +NG + + PA +Y Y D+ +F CH+
Sbjct: 354 WTPYQGCEALCCPEP-KLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSA----I 408
Query: 248 CTKLGNWS-AMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHG-DKVSFFCKNKEK 305
C G WS PSC C P K A Y ++ FK +++ DK +
Sbjct: 409 CQGDGTWSPRTPSCGDICNFPPKIAHGHY--KQSSSYSFFKEEIIYECDKGYILVGQAKL 466
Query: 306 KCSYT 310
CSY+
Sbjct: 467 SCSYS 471
Score = 66.2 bits (160), Expect = 4e-11
Identities = 62/233 (26%), Positives = 96/233 (41%), Gaps = 27/233 (11%)
Query: 41 YEPGEEITYSCKPGYV-SRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAV---- 95
Y G + Y C PGY + IC W C CP L NG +
Sbjct: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ-GCEALCCPEPK-LNNGEITQHR 379
Query: 96 -----RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTF 150
+ + Y + ISFSC+ SA C +G WSP P C I PP I
Sbjct: 380 KSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHG 435
Query: 151 ATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK-LPECREVKCPFPS 209
YK S+ + S +++ ++EC + + G ++C+ + +W+ P+C+ + C P
Sbjct: 436 H----YKQSS-SYSFFKEEIIYECDKGYILVGQAKLSCS-YSHWSAPAPQCKAL-CRKPE 488
Query: 210 RPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW-SAMPSCK 261
NG ++ K + T C GY + GP+ I C+ W +P C+
Sbjct: 489 LV-NGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 105 bits (262), Expect = 6e-23
Identities = 71/262 (27%), Positives = 103/262 (39%), Gaps = 11/262 (4%)
Query: 9 FSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPL 68
FS C + P+ PL F + SC GY+ M C
Sbjct: 169 FSGLKCEQIVNCTALESPEHGSLVCSHPLGNF-SYNSSCSISCDRGYLP-SSMETMQCMS 226
Query: 69 TGLWPINTLKCTPRVCPFAGILENGAVRYT----TFEYPNTISFSCNTGFYLNGADSAKC 124
+G W C C NG V +F + T +F C GF L GA S +C
Sbjct: 227 SGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQC 286
Query: 125 TEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGND 184
T G W E P C + C P ++R AG + ++ + F C + G
Sbjct: 287 TSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT-FKSSCNFTCEEGFMLQGPA 345
Query: 185 TITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNY--PAKPTLYYKDKATFGCHDGYSLD 241
+ CTT G WT ++P C +C S P+ G++N A + Y F C G+ L
Sbjct: 346 QVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLK 405
Query: 242 GPEEIECTKLGNW-SAMPSCKA 262
G + ++C G W + P+C+A
Sbjct: 406 GSKRLQCGPTGEWDNEKPTCEA 427
Score = 95.5 bits (236), Expect = 6e-20
Identities = 59/221 (26%), Positives = 98/221 (44%), Gaps = 11/221 (4%)
Query: 49 YSCKPGYVSRGGMRKFICPLTGLW----PI-NTLKCTPRVCPFAGILENGAVRYTTFEYP 103
++C+ G++ +G + C G W P+ +CT P G + +F Y
Sbjct: 333 FTCEEGFMLQGPAQ-VECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYG 391
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
++ FSC GF L G+ +C G+W E P C + C P +R G
Sbjct: 392 SSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEF 451
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKP 222
+ Y+ + F C + G+ + CT+ G WT ++P C+ VKC + P G +N
Sbjct: 452 T-YKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVP--GKINMSCSG 508
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262
+ F C +G++L+G C G+WS +P+C+A
Sbjct: 509 EPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
Score = 72.4 bits (176), Expect = 6e-13
Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 12/163 (7%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYT----- 98
G +SC+ G+V +G R C TG W C C G VR
Sbjct: 391 GSSCEFSCEQGFVLKGSKR-LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIG 449
Query: 99 TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKP 158
F Y ++ +FSC GF L+G+ +CT +G+W+ E+P C + C ++P +
Sbjct: 450 EFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINM----- 504
Query: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC 200
S ++ F C + G+ TC G+W+ LP C
Sbjct: 505 SCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 101 bits (251), Expect = 1e-21
Identities = 73/237 (30%), Positives = 97/237 (40%), Gaps = 15/237 (6%)
Query: 37 LKTFYEPGEEITYSCKPGY-VSRGGMRKFICPLTGLWPIN--TLKCTPRVCPFAGILENG 93
L T Y G +TY C GY +S + +C G W + T +C C NG
Sbjct: 2540 LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNG 2599
Query: 94 AVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATL 153
T Y +T F+C+ GF L G+ +C G WS C C P L
Sbjct: 2600 NKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE------L 2653
Query: 154 RVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPD 212
V G N YRDT V++C P + G+ C NW+ +LP C V C P P
Sbjct: 2654 IVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPI 2713
Query: 213 NGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCK-ASCKVP 267
G + + D TF C+ GY + GP + +C WS P CK +C P
Sbjct: 2714 YGRTSGNG---FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDP 2767
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/262 (25%), Positives = 105/262 (40%), Gaps = 13/262 (4%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
+C + P + +T Y G ++C G++ G + C +GLW + +C
Sbjct: 2589 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRE-CLSSGLWSESETRCLA 2645
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPII 141
C ++ NG V + Y +T+ + CN GF L G+ C ++ WS +LP C P+
Sbjct: 2646 GHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS 2705
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-C 200
C P P +Y ++GN + D F C + M G C + W+ P C
Sbjct: 2706 CGHPGSP------IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC 2759
Query: 201 REVKCPFPSRPDNGFVNYPAK-PTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW-SAMP 258
+ V C P P N + Y + C+ GY L G + C G W +P
Sbjct: 2760 KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLP 2819
Query: 259 SC-KASCKVPVKKATVVYQGER 279
C C P V GE+
Sbjct: 2820 ECIMIDCGHPGVPPNAVLSGEK 2841
Score = 97.4 bits (241), Expect = 2e-20
Identities = 67/234 (28%), Positives = 91/234 (38%), Gaps = 15/234 (6%)
Query: 41 YEPGEEITYSCKPGYVSR-GGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTT 99
Y G+ ++Y C+PGY G R C + G W C CP + NG + T
Sbjct: 3020 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN 3079
Query: 100 FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
F++ +IS+ C+ G+ L+ C G WS E+P C P C P IP
Sbjct: 3080 FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP------AQGKR 3133
Query: 160 AGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECRE---VKCPFPSRPDNGF 215
G + +Y+ F C + G+ T C G W+ P C E C P P +G
Sbjct: 3134 EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGS 3193
Query: 216 VNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSC-KASCKVP 267
N F C G+ L G C WS + P C SCK P
Sbjct: 3194 QNNTF--GFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP 3245
Score = 97.1 bits (240), Expect = 2e-20
Identities = 65/219 (29%), Positives = 94/219 (42%), Gaps = 15/219 (6%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAV-RYTTFEYPNT 105
+ Y+C GY+ G + C G W +C C G NG V R + ++
Sbjct: 2909 VRYACDTGYILHGSEER-TCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS 2967
Query: 106 ISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSL 165
+ +SC G+ L+G +CT G WS LP C I C P IP LR G++ +
Sbjct: 2968 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-LRY-----GDDYV 3021
Query: 166 YRDTAVFECLPQHAM--FGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKP 222
+ C P + M G+ TCT +G W+ +P CR V CP P + NG +
Sbjct: 3022 VGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE---GT 3078
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSC 260
+ ++ C GY L P + C G WS +P C
Sbjct: 3079 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQC 3117
Score = 96.3 bits (238), Expect = 4e-20
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 25/228 (10%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGA----VRYTTFEY 102
+T+SC GY+ +G K C W C C GI N + + F Y
Sbjct: 2728 VTFSCNIGYLMQGPT-KAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY 2786
Query: 103 PNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGN 162
+ + CN G++L G+ C G+W LP C I C P +P A L +G
Sbjct: 2787 GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGE 2840
Query: 163 NSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC---REVKCPFPSRPDNGF--- 215
+ T + C + ++ G + TC +G+W+ P C C P P +G
Sbjct: 2841 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 2900
Query: 216 VNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262
N+ K T+ Y C GY L G EE C G+W+ P CKA
Sbjct: 2901 SNFRTKSTVRY------ACDTGYILHGSEERTCLANGSWTGRQPECKA 2942
Score = 95.1 bits (235), Expect = 8e-20
Identities = 81/308 (26%), Positives = 128/308 (41%), Gaps = 55/308 (17%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCT---PRVCPFAGILENGAVRY 97
Y G + YSC G S G C L G W + C+ C G +G+ +
Sbjct: 2842 YTFGSTVHYSCT-GKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 2900
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK 157
+ F +T+ ++C+TG+ L+G++ C G W+ P C + C P T A +V++
Sbjct: 2901 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG--TTANGKVFR 2958
Query: 158 PSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFV 216
+ + + + ++ C+ + + G CT +G W+ LP C + C P P NG
Sbjct: 2959 I---DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-- 3013
Query: 217 NYPAKPTLYYKDKATFG------CHDGYS--LDGPEEIECTKLGNWS-AMPSCKA-SCKV 266
L Y D G C GY+ L+G CT G WS MP+C+A +C
Sbjct: 3014 -------LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT 3066
Query: 267 PVKKATVVYQGERVKIQEKFKNGMLHGD------KVSFFCKNKEKKCSYTEDAQCI-DGT 319
P + NG L G +S+ C + + S+ C+ +GT
Sbjct: 3067 P----------------PQISNGRLEGTNFDWGFSISYIC-SPGYELSFPAVLTCVGNGT 3109
Query: 320 I--EVPKC 325
EVP+C
Sbjct: 3110 WSGEVPQC 3117
Score = 90.1 bits (222), Expect = 3e-18
Identities = 72/257 (28%), Positives = 101/257 (39%), Gaps = 22/257 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
TCP P + + T ++ G I+Y C PGY C G W +C P
Sbjct: 3063 TCPTPPQISNGRLEG--TNFDWGFSISYICSPGY-ELSFPAVLTCVGNGTWSGEVPQCLP 3119
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC---A 138
+ C GI G +F Y + +SFSCN F L G+ + C +G WS P C
Sbjct: 3120 KFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPT 3179
Query: 139 PIICPPPSIPTFATLRVYKPSAGNNSL---YRDTAVFECLPQHAMFGNDTITCTTHGNWT 195
C P +P + + NN+ F C H + G+ T TC W+
Sbjct: 3180 QTSCENPGVP--------RHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3231
Query: 196 KL-PECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL-DGPEEIECTKLGN 253
+ PEC C P P + V P+ Y + C G+ L G E C
Sbjct: 3232 GIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRSDNT 3289
Query: 254 WSA-MPSCKASCKVPVK 269
W+ +P C+A K+ VK
Sbjct: 3290 WTGKVPICEAGSKILVK 3306
Score = 58.9 bits (141), Expect = 6e-09
Identities = 55/206 (26%), Positives = 84/206 (40%), Gaps = 29/206 (14%)
Query: 46 EITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC---TPRVCPFAGILENGAVRYTT-FE 101
E+++SC ++ G + IC G W ++ C T C G+ +G+ T F+
Sbjct: 3143 EVSFSCNFPFILVGSSTR-ICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3201
Query: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFA-TLRVYKPSA 160
+ + F C G L G+ + C + WS P C P C P P A + + PS
Sbjct: 3202 VGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH 3261
Query: 161 GNNSLYRDTAVFECLPQHAMF-GNDTITCTTHGNWT-KLPECRE-----VKCPFP----- 208
G T ++ C P + G + C + WT K+P C VK P P
Sbjct: 3262 GY------TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTP 3315
Query: 209 ----SRPDNGFV-NYPAKPTLYYKDK 229
S PD+ F NY K + +K +
Sbjct: 3316 SPKLSVPDDVFAQNYIWKGSYNFKGR 3341
Score = 54.3 bits (129), Expect = 2e-07
Identities = 48/175 (27%), Positives = 65/175 (37%), Gaps = 20/175 (11%)
Query: 104 NTISFSCNTGFYLNGADSAKCTEEG----KWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
+ + ++C+ GF L G SA C + W +P C I C P PT +
Sbjct: 2486 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL 2545
Query: 160 AGNNSLYRDTAVFECLPQHAMFGND--TITCTTHGNWT---KLPECREVKCPFPSRPDNG 214
G Y C + + + T C + G W+ K P C + C P NG
Sbjct: 2546 VGTRVTY------FCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNG 2599
Query: 215 FVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPS-CKAS-CKVP 267
N T Y A F C G+ L G EC G WS + C A C +P
Sbjct: 2600 --NKIGTQT-SYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIP 2651
Score = 45.4 bits (106), Expect = 7e-05
Identities = 59/243 (24%), Positives = 81/243 (33%), Gaps = 58/243 (23%)
Query: 74 INTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPE 133
+NT C GI +G F +T+SFSC++G+ L+ + C + WS
Sbjct: 901 VNTYSCLD-----PGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 955
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAV---------FECLPQHAMFGND 184
LP C + P+ L P NSL V F H +D
Sbjct: 956 LPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHD 1015
Query: 185 TITCTTHGNWTKLPECREVKCPFPSRPDNG-------------------------FVNYP 219
+ T +G++T+ P R P + G F Y
Sbjct: 1016 YLLITENGSFTQ-PLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074
Query: 220 AKP---------------TLYYKDKATFGCHDGYSLDGPEEIECTKLGN--WSA-MPSCK 261
+P D TF C GY L+G EI C G WSA +P C
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Query: 262 ASC 264
A C
Sbjct: 1135 AEC 1137
Score = 42.0 bits (97), Expect = 8e-04
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 4/70 (5%)
Query: 77 LKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK----WSP 132
+K +CP G ENG + F +T+ FSC+ + L GA S C + WS
Sbjct: 375 IKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 434
Query: 133 ELPVCAPIIC 142
PVC C
Sbjct: 435 HRPVCKVKTC 444
Score = 38.1 bits (87), Expect = 0.012
Identities = 25/69 (36%), Positives = 30/69 (43%), Gaps = 6/69 (8%)
Query: 161 GNNSLYRDTAVFECLPQHAMFGNDTITCTTHG---NWT-KLPECREVKCPFPSRPDNGFV 216
GN+ T FEC P + + GN +TC HG NW LP C E C NG +
Sbjct: 2133 GNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRC-EALCGGNITAMNGTI 2190
Query: 217 NYPAKPTLY 225
P P Y
Sbjct: 2191 YSPGYPDEY 2199
Score = 36.6 bits (83), Expect = 0.034
Identities = 18/53 (33%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 85 PFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
P GI E F + + F C GF L G S C E +WS +P+C
Sbjct: 566 PLYGIREGDG-----FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 33.1 bits (74), Expect = 0.37
Identities = 58/243 (23%), Positives = 90/243 (37%), Gaps = 45/243 (18%)
Query: 42 EPGEEITYSCKPGYVSRGGMRKFICPLTG--LWPINTLKCTPRVCPFAGIL--ENGAVRY 97
EPG+ + + C PGY +G R + W + C + P G L +G +
Sbjct: 1441 EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC---IAPCGGNLTGSSGFILS 1497
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK 157
F +P S C+ +N AD +S E P + L +Y
Sbjct: 1498 PNFPHPYPHSRDCDWTITVN-ADYVISLAFISFSIE--------------PNYDFLYIYD 1542
Query: 158 PSAGNNSL---YRDTAVFECL-----PQHAMFGNDTITCTTHGNWTKLPECREVKCPFPS 209
N+ L ++D+ + E + H F +D T + + RE C P
Sbjct: 1543 GPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE-SCFDPG 1601
Query: 210 RPDNGFVNYPAKPTLYYK--DKATFGCHDGYSLDGPEEIECTKLGN-----WS-AMPSCK 261
NG + + YK T+ C GY L G + C +G+ W+ A+PSC
Sbjct: 1602 NIMNG-----TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI-MGDDGRPGWNRALPSCH 1655
Query: 262 ASC 264
A C
Sbjct: 1656 APC 1658
Score = 32.7 bits (73), Expect = 0.49
Identities = 16/58 (27%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKC----TEEGKWSPELPVC 137
C G+ G + T F+ + I +SC TG+ L+G C W +P+C
Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
Score = 32.3 bits (72), Expect = 0.64
Identities = 22/64 (34%), Positives = 26/64 (40%), Gaps = 7/64 (10%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---WS-AMPSC 260
C P P NG N + D F C GY L G E I C ++ N W + P C
Sbjct: 1424 CRDPGVPMNGTRNGDGREP---GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Query: 261 KASC 264
A C
Sbjct: 1481 IAPC 1484
Score = 32.0 bits (71), Expect = 0.83
Identities = 28/125 (22%), Positives = 45/125 (36%), Gaps = 18/125 (14%)
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
N ++ +T FY++ + ++ + C P +P T G+
Sbjct: 1395 NIVTIQFDTDFYIS---------KSGFAIQFSSSVATACRDPGVPMNGTRN------GDG 1439
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGN---WTKLPECREVKCPFPSRPDNGFVNYPA 220
DT VF+C P + + G + ITC N W P C +GF+ P
Sbjct: 1440 REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN 1499
Query: 221 KPTLY 225
P Y
Sbjct: 1500 FPHPY 1504
Score = 32.0 bits (71), Expect = 0.83
Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 3/57 (5%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVC 137
C G+ NG E +T+ F C+ G+ L G + C + W P PVC
Sbjct: 1424 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Score = 32.0 bits (71), Expect = 0.83
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 6/63 (9%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT--KLGNWS-AMPSCK 261
CP P P +G D +F C GYSL G I C + W+ +P C
Sbjct: 1948 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2004
Query: 262 ASC 264
A C
Sbjct: 2005 AQC 2007
Score = 31.6 bits (70), Expect = 1.1
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 2/56 (3%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTE--EGKWSPELPVC 137
CP NG V F TISF C G+ L G + C W+ LP C
Sbjct: 2120 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2175
Score = 30.8 bits (68), Expect = 1.9
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 104 NTISFSCNTGFYLNGADSAKCT--EEGKWSPELPVC 137
+TI + CN G+ L+G+ KC E W LP C
Sbjct: 1271 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1306
Score = 28.9 bits (63), Expect = 7.0
Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 227 KDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKASC 264
+D F C G+ L G + I C + WSA +P C C
Sbjct: 579 RDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 617
Score = 28.5 bits (62), Expect = 9.2
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 8/79 (10%)
Query: 189 TTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIEC 248
+ HG E + C P P G V Y + + DK + C GY LDG ++ C
Sbjct: 162 SAHGFKVYYEELQSSSCGNPGVPPKG-VLYGTRFDV--GDKIRYSCVTGYILDGHPQLTC 218
Query: 249 ----TKLGNWS-AMPSCKA 262
+W +P C+A
Sbjct: 219 IANSVNTASWDFPVPICRA 237
Score = 28.5 bits (62), Expect = 9.2
Identities = 17/63 (26%), Positives = 25/63 (39%), Gaps = 4/63 (6%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN-WSAMPSCKAS 263
CP P P+NG F C + Y L G + I C ++ ++A +
Sbjct: 382 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 438
Query: 264 CKV 266
CKV
Sbjct: 439 CKV 441
Score = 28.5 bits (62), Expect = 9.2
Identities = 31/126 (24%), Positives = 47/126 (37%), Gaps = 21/126 (16%)
Query: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNY 218
S+GN R T+V + F + T+ + +PE R F R N F
Sbjct: 1739 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR-----FGRRIGNEFA-- 1791
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIEC----TKLGNWS-AMPSCKASCK--VPVKKA 271
F C+ GY L G I C L W+ ++P+C C + +K
Sbjct: 1792 -------VGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKG 1844
Query: 272 TVVYQG 277
T++ G
Sbjct: 1845 TILSPG 1850
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/262 (25%), Positives = 105/262 (40%), Gaps = 13/262 (4%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
+C + P + +T Y G ++C G++ G + C +GLW + +C
Sbjct: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRE-CLSSGLWSESETRCLA 2774
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPII 141
C ++ NG V + Y +T+ + CN GF L G+ C ++ WS +LP C P+
Sbjct: 2775 GHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS 2834
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-C 200
C P P +Y ++GN + D F C + M G C + W+ P C
Sbjct: 2835 CGHPGSP------IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC 2888
Query: 201 REVKCPFPSRPDNGFVNYPAK-PTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW-SAMP 258
+ V C P P N + Y + C+ GY L G + C G W +P
Sbjct: 2889 KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLP 2948
Query: 259 SC-KASCKVPVKKATVVYQGER 279
C C P V GE+
Sbjct: 2949 ECIMIDCGHPGVPPNAVLSGEK 2970
Score = 97.4 bits (241), Expect = 2e-20
Identities = 67/234 (28%), Positives = 91/234 (38%), Gaps = 15/234 (6%)
Query: 41 YEPGEEITYSCKPGYVSR-GGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTT 99
Y G+ ++Y C+PGY G R C + G W C CP + NG + T
Sbjct: 3149 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN 3208
Query: 100 FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
F++ +IS+ C+ G+ L+ C G WS E+P C P C P IP
Sbjct: 3209 FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP------AQGKR 3262
Query: 160 AGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECRE---VKCPFPSRPDNGF 215
G + +Y+ F C + G+ T C G W+ P C E C P P +G
Sbjct: 3263 EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGS 3322
Query: 216 VNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSC-KASCKVP 267
N F C G+ L G C WS + P C SCK P
Sbjct: 3323 QNNTF--GFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP 3374
Score = 97.1 bits (240), Expect = 2e-20
Identities = 65/219 (29%), Positives = 94/219 (42%), Gaps = 15/219 (6%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAV-RYTTFEYPNT 105
+ Y+C GY+ G + C G W +C C G NG V R + ++
Sbjct: 3038 VRYACDTGYILHGSEER-TCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS 3096
Query: 106 ISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSL 165
+ +SC G+ L+G +CT G WS LP C I C P IP LR G++ +
Sbjct: 3097 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-LRY-----GDDYV 3150
Query: 166 YRDTAVFECLPQHAM--FGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKP 222
+ C P + M G+ TCT +G W+ +P CR V CP P + NG +
Sbjct: 3151 VGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE---GT 3207
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSC 260
+ ++ C GY L P + C G WS +P C
Sbjct: 3208 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQC 3246
Score = 96.3 bits (238), Expect = 4e-20
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 25/228 (10%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGA----VRYTTFEY 102
+T+SC GY+ +G K C W C C GI N + + F Y
Sbjct: 2857 VTFSCNIGYLMQGPT-KAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY 2915
Query: 103 PNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGN 162
+ + CN G++L G+ C G+W LP C I C P +P A L +G
Sbjct: 2916 GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGE 2969
Query: 163 NSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC---REVKCPFPSRPDNGF--- 215
+ T + C + ++ G + TC +G+W+ P C C P P +G
Sbjct: 2970 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 3029
Query: 216 VNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262
N+ K T+ Y C GY L G EE C G+W+ P CKA
Sbjct: 3030 SNFRTKSTVRY------ACDTGYILHGSEERTCLANGSWTGRQPECKA 3071
Score = 95.1 bits (235), Expect = 8e-20
Identities = 81/308 (26%), Positives = 128/308 (41%), Gaps = 55/308 (17%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCT---PRVCPFAGILENGAVRY 97
Y G + YSC G S G C L G W + C+ C G +G+ +
Sbjct: 2971 YTFGSTVHYSCT-GKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 3029
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK 157
+ F +T+ ++C+TG+ L+G++ C G W+ P C + C P T A +V++
Sbjct: 3030 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG--TTANGKVFR 3087
Query: 158 PSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFV 216
+ + + + ++ C+ + + G CT +G W+ LP C + C P P NG
Sbjct: 3088 I---DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-- 3142
Query: 217 NYPAKPTLYYKDKATFG------CHDGYS--LDGPEEIECTKLGNWS-AMPSCKA-SCKV 266
L Y D G C GY+ L+G CT G WS MP+C+A +C
Sbjct: 3143 -------LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT 3195
Query: 267 PVKKATVVYQGERVKIQEKFKNGMLHGD------KVSFFCKNKEKKCSYTEDAQCI-DGT 319
P + NG L G +S+ C + + S+ C+ +GT
Sbjct: 3196 P----------------PQISNGRLEGTNFDWGFSISYIC-SPGYELSFPAVLTCVGNGT 3238
Query: 320 I--EVPKC 325
EVP+C
Sbjct: 3239 WSGEVPQC 3246
Score = 94.4 bits (233), Expect = 1e-19
Identities = 81/296 (27%), Positives = 109/296 (36%), Gaps = 68/296 (22%)
Query: 37 LKTFYEPGEEITYSCKPGY-VSRGGMRKFICPLTGLWPIN--TLKCTPRVCPFAG--ILE 91
L T Y G +TY C GY +S + +C G W + T +C CP ILE
Sbjct: 2604 LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILE 2663
Query: 92 NGAVRYTT---FEYPNTISFSCNTGFYLNGADSAKCTEEGKWS--PELPVCAPIIC---- 142
+G R +EY + FSC+ G++ G S +C G WS E P C I C
Sbjct: 2664 HGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723
Query: 143 PPPSIPTFATLRVYKPSA------------------------------------------ 160
PP+ T Y +A
Sbjct: 2724 TPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2783
Query: 161 ------GNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDN 213
G N YRDT V++C P + G+ C NW+ +LP C V C P P
Sbjct: 2784 VNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIY 2843
Query: 214 GFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCK-ASCKVP 267
G + + D TF C+ GY + GP + +C WS P CK +C P
Sbjct: 2844 GRTSGNG---FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDP 2896
Score = 90.1 bits (222), Expect = 3e-18
Identities = 72/257 (28%), Positives = 101/257 (39%), Gaps = 22/257 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
TCP P + + T ++ G I+Y C PGY C G W +C P
Sbjct: 3192 TCPTPPQISNGRLEG--TNFDWGFSISYICSPGY-ELSFPAVLTCVGNGTWSGEVPQCLP 3248
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC---A 138
+ C GI G +F Y + +SFSCN F L G+ + C +G WS P C
Sbjct: 3249 KFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPT 3308
Query: 139 PIICPPPSIPTFATLRVYKPSAGNNSL---YRDTAVFECLPQHAMFGNDTITCTTHGNWT 195
C P +P + + NN+ F C H + G+ T TC W+
Sbjct: 3309 QTSCENPGVP--------RHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3360
Query: 196 KL-PECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL-DGPEEIECTKLGN 253
+ PEC C P P + V P+ Y + C G+ L G E C
Sbjct: 3361 GIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRSDNT 3418
Query: 254 WSA-MPSCKASCKVPVK 269
W+ +P C+A K+ VK
Sbjct: 3419 WTGKVPICEAGSKILVK 3435
Score = 69.7 bits (169), Expect = 4e-12
Identities = 65/259 (25%), Positives = 104/259 (40%), Gaps = 21/259 (8%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGL----WPINTLK 78
C P+ P ++ +T + + ++C G+ G +C + W
Sbjct: 2529 CSTPESPPHGYIIS-QTGGQLNSVVRWACDRGF-RLVGKSSAVCRKSSYGYHAWDAPVPA 2586
Query: 79 CTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD--SAKCTEEGKWS--PEL 134
C C NG + T + +++ CN G+ L+ + +A C +G WS +
Sbjct: 2587 CQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2646
Query: 135 PVCAPIICPPPSIPTFATLR-VYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGN 193
P C + C PSI +F ++ G++ Y+ VF C P + G +I C +G
Sbjct: 2647 PRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704
Query: 194 WT---KLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTK 250
W+ + P C+ + C P NG N T Y A F C G+ L G EC
Sbjct: 2705 WSWRNERPYCQIISCGELPTPPNG--NKIGTQT-SYGSTAIFTCDLGFMLVGSAVRECLS 2761
Query: 251 LGNWSAMPS-CKAS-CKVP 267
G WS + C A C +P
Sbjct: 2762 SGLWSESETRCLAGHCGIP 2780
Score = 58.9 bits (141), Expect = 6e-09
Identities = 55/206 (26%), Positives = 84/206 (40%), Gaps = 29/206 (14%)
Query: 46 EITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC---TPRVCPFAGILENGAVRYTT-FE 101
E+++SC ++ G + IC G W ++ C T C G+ +G+ T F+
Sbjct: 3272 EVSFSCNFPFILVGSSTR-ICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3330
Query: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFA-TLRVYKPSA 160
+ + F C G L G+ + C + WS P C P C P P A + + PS
Sbjct: 3331 VGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH 3390
Query: 161 GNNSLYRDTAVFECLPQHAMF-GNDTITCTTHGNWT-KLPECRE-----VKCPFP----- 208
G T ++ C P + G + C + WT K+P C VK P P
Sbjct: 3391 GY------TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTP 3444
Query: 209 ----SRPDNGFV-NYPAKPTLYYKDK 229
S PD+ F NY K + +K +
Sbjct: 3445 SPKLSVPDDVFAQNYIWKGSYNFKGR 3470
Score = 45.4 bits (106), Expect = 7e-05
Identities = 59/243 (24%), Positives = 81/243 (33%), Gaps = 58/243 (23%)
Query: 74 INTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPE 133
+NT C GI +G F +T+SFSC++G+ L+ + C + WS
Sbjct: 965 VNTYSCLD-----PGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 1019
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAV---------FECLPQHAMFGND 184
LP C + P+ L P NSL V F H +D
Sbjct: 1020 LPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHD 1079
Query: 185 TITCTTHGNWTKLPECREVKCPFPSRPDNG-------------------------FVNYP 219
+ T +G++T+ P R P + G F Y
Sbjct: 1080 YLLITENGSFTQ-PLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138
Query: 220 AKP---------------TLYYKDKATFGCHDGYSLDGPEEIECTKLGN--WSA-MPSCK 261
+P D TF C GY L+G EI C G WSA +P C
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Query: 262 ASC 264
A C
Sbjct: 1199 AEC 1201
Score = 42.0 bits (97), Expect = 8e-04
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 4/70 (5%)
Query: 77 LKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK----WSP 132
+K +CP G ENG + F +T+ FSC+ + L GA S C + WS
Sbjct: 439 IKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 498
Query: 133 ELPVCAPIIC 142
PVC C
Sbjct: 499 HRPVCKVKTC 508
Score = 38.1 bits (87), Expect = 0.012
Identities = 25/69 (36%), Positives = 30/69 (43%), Gaps = 6/69 (8%)
Query: 161 GNNSLYRDTAVFECLPQHAMFGNDTITCTTHG---NWT-KLPECREVKCPFPSRPDNGFV 216
GN+ T FEC P + + GN +TC HG NW LP C E C NG +
Sbjct: 2197 GNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRC-EALCGGNITAMNGTI 2254
Query: 217 NYPAKPTLY 225
P P Y
Sbjct: 2255 YSPGYPDEY 2263
Score = 36.6 bits (83), Expect = 0.034
Identities = 18/53 (33%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 85 PFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
P GI E F + + F C GF L G S C E +WS +P+C
Sbjct: 630 PLYGIREGDG-----FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677
Score = 33.1 bits (74), Expect = 0.37
Identities = 58/243 (23%), Positives = 90/243 (37%), Gaps = 45/243 (18%)
Query: 42 EPGEEITYSCKPGYVSRGGMRKFICPLTG--LWPINTLKCTPRVCPFAGIL--ENGAVRY 97
EPG+ + + C PGY +G R + W + C + P G L +G +
Sbjct: 1505 EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC---IAPCGGNLTGSSGFILS 1561
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK 157
F +P S C+ +N AD +S E P + L +Y
Sbjct: 1562 PNFPHPYPHSRDCDWTITVN-ADYVISLAFISFSIE--------------PNYDFLYIYD 1606
Query: 158 PSAGNNSL---YRDTAVFECL-----PQHAMFGNDTITCTTHGNWTKLPECREVKCPFPS 209
N+ L ++D+ + E + H F +D T + + RE C P
Sbjct: 1607 GPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE-SCFDPG 1665
Query: 210 RPDNGFVNYPAKPTLYYK--DKATFGCHDGYSLDGPEEIECTKLGN-----WS-AMPSCK 261
NG + + YK T+ C GY L G + C +G+ W+ A+PSC
Sbjct: 1666 NIMNG-----TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI-MGDDGRPGWNRALPSCH 1719
Query: 262 ASC 264
A C
Sbjct: 1720 APC 1722
Score = 32.7 bits (73), Expect = 0.49
Identities = 16/58 (27%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKC----TEEGKWSPELPVC 137
C G+ G + T F+ + I +SC TG+ L+G C W +P+C
Sbjct: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195
Score = 32.3 bits (72), Expect = 0.64
Identities = 22/64 (34%), Positives = 26/64 (40%), Gaps = 7/64 (10%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---WS-AMPSC 260
C P P NG N + D F C GY L G E I C ++ N W + P C
Sbjct: 1488 CRDPGVPMNGTRNGDGREP---GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Query: 261 KASC 264
A C
Sbjct: 1545 IAPC 1548
Score = 32.0 bits (71), Expect = 0.83
Identities = 28/125 (22%), Positives = 45/125 (36%), Gaps = 18/125 (14%)
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
N ++ +T FY++ + ++ + C P +P T G+
Sbjct: 1459 NIVTIQFDTDFYIS---------KSGFAIQFSSSVATACRDPGVPMNGTRN------GDG 1503
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGN---WTKLPECREVKCPFPSRPDNGFVNYPA 220
DT VF+C P + + G + ITC N W P C +GF+ P
Sbjct: 1504 REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN 1563
Query: 221 KPTLY 225
P Y
Sbjct: 1564 FPHPY 1568
Score = 32.0 bits (71), Expect = 0.83
Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 3/57 (5%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVC 137
C G+ NG E +T+ F C+ G+ L G + C + W P PVC
Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Score = 32.0 bits (71), Expect = 0.83
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 6/63 (9%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT--KLGNWS-AMPSCK 261
CP P P +G D +F C GYSL G I C + W+ +P C
Sbjct: 2012 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2068
Query: 262 ASC 264
A C
Sbjct: 2069 AQC 2071
Score = 31.6 bits (70), Expect = 1.1
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 2/56 (3%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTE--EGKWSPELPVC 137
CP NG V F TISF C G+ L G + C W+ LP C
Sbjct: 2184 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2239
Score = 30.8 bits (68), Expect = 1.9
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 104 NTISFSCNTGFYLNGADSAKCT--EEGKWSPELPVC 137
+TI + CN G+ L+G+ KC E W LP C
Sbjct: 1335 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1370
Score = 28.9 bits (63), Expect = 7.0
Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 227 KDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKASC 264
+D F C G+ L G + I C + WSA +P C C
Sbjct: 643 RDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681
Score = 28.5 bits (62), Expect = 9.2
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 8/79 (10%)
Query: 189 TTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIEC 248
+ HG E + C P P G V Y + + DK + C GY LDG ++ C
Sbjct: 122 SAHGFKVYYEELQSSSCGNPGVPPKG-VLYGTRFDV--GDKIRYSCVTGYILDGHPQLTC 178
Query: 249 ----TKLGNWS-AMPSCKA 262
+W +P C+A
Sbjct: 179 IANSVNTASWDFPVPICRA 197
Score = 28.5 bits (62), Expect = 9.2
Identities = 17/63 (26%), Positives = 25/63 (39%), Gaps = 4/63 (6%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN-WSAMPSCKAS 263
CP P P+NG F C + Y L G + I C ++ ++A +
Sbjct: 446 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502
Query: 264 CKV 266
CKV
Sbjct: 503 CKV 505
Score = 28.5 bits (62), Expect = 9.2
Identities = 31/126 (24%), Positives = 47/126 (37%), Gaps = 21/126 (16%)
Query: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNY 218
S+GN R T+V + F + T+ + +PE R F R N F
Sbjct: 1803 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR-----FGRRIGNEFA-- 1855
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIEC----TKLGNWS-AMPSCKASCK--VPVKKA 271
F C+ GY L G I C L W+ ++P+C C + +K
Sbjct: 1856 -------VGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKG 1908
Query: 272 TVVYQG 277
T++ G
Sbjct: 1909 TILSPG 1914
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/262 (25%), Positives = 105/262 (40%), Gaps = 13/262 (4%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
+C + P + +T Y G ++C G++ G + C +GLW + +C
Sbjct: 2758 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRE-CLSSGLWSESETRCLA 2814
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPII 141
C ++ NG V + Y +T+ + CN GF L G+ C ++ WS +LP C P+
Sbjct: 2815 GHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS 2874
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-C 200
C P P +Y ++GN + D F C + M G C + W+ P C
Sbjct: 2875 CGHPGSP------IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC 2928
Query: 201 REVKCPFPSRPDNGFVNYPAK-PTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW-SAMP 258
+ V C P P N + Y + C+ GY L G + C G W +P
Sbjct: 2929 KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLP 2988
Query: 259 SC-KASCKVPVKKATVVYQGER 279
C C P V GE+
Sbjct: 2989 ECIMIDCGHPGVPPNAVLSGEK 3010
Score = 97.4 bits (241), Expect = 2e-20
Identities = 67/234 (28%), Positives = 91/234 (38%), Gaps = 15/234 (6%)
Query: 41 YEPGEEITYSCKPGYVSR-GGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTT 99
Y G+ ++Y C+PGY G R C + G W C CP + NG + T
Sbjct: 3189 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN 3248
Query: 100 FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
F++ +IS+ C+ G+ L+ C G WS E+P C P C P IP
Sbjct: 3249 FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP------AQGKR 3302
Query: 160 AGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECRE---VKCPFPSRPDNGF 215
G + +Y+ F C + G+ T C G W+ P C E C P P +G
Sbjct: 3303 EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGS 3362
Query: 216 VNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSC-KASCKVP 267
N F C G+ L G C WS + P C SCK P
Sbjct: 3363 QNNTF--GFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP 3414
Score = 97.1 bits (240), Expect = 2e-20
Identities = 65/219 (29%), Positives = 94/219 (42%), Gaps = 15/219 (6%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAV-RYTTFEYPNT 105
+ Y+C GY+ G + C G W +C C G NG V R + ++
Sbjct: 3078 VRYACDTGYILHGSEER-TCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS 3136
Query: 106 ISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSL 165
+ +SC G+ L+G +CT G WS LP C I C P IP LR G++ +
Sbjct: 3137 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-LRY-----GDDYV 3190
Query: 166 YRDTAVFECLPQHAM--FGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKP 222
+ C P + M G+ TCT +G W+ +P CR V CP P + NG +
Sbjct: 3191 VGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE---GT 3247
Query: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSC 260
+ ++ C GY L P + C G WS +P C
Sbjct: 3248 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQC 3286
Score = 96.3 bits (238), Expect = 4e-20
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 25/228 (10%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGA----VRYTTFEY 102
+T+SC GY+ +G K C W C C GI N + + F Y
Sbjct: 2897 VTFSCNIGYLMQGPT-KAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY 2955
Query: 103 PNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGN 162
+ + CN G++L G+ C G+W LP C I C P +P A L +G
Sbjct: 2956 GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGE 3009
Query: 163 NSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC---REVKCPFPSRPDNGF--- 215
+ T + C + ++ G + TC +G+W+ P C C P P +G
Sbjct: 3010 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 3069
Query: 216 VNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262
N+ K T+ Y C GY L G EE C G+W+ P CKA
Sbjct: 3070 SNFRTKSTVRY------ACDTGYILHGSEERTCLANGSWTGRQPECKA 3111
Score = 95.1 bits (235), Expect = 8e-20
Identities = 81/308 (26%), Positives = 128/308 (41%), Gaps = 55/308 (17%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCT---PRVCPFAGILENGAVRY 97
Y G + YSC G S G C L G W + C+ C G +G+ +
Sbjct: 3011 YTFGSTVHYSCT-GKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 3069
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK 157
+ F +T+ ++C+TG+ L+G++ C G W+ P C + C P T A +V++
Sbjct: 3070 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG--TTANGKVFR 3127
Query: 158 PSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFV 216
+ + + + ++ C+ + + G CT +G W+ LP C + C P P NG
Sbjct: 3128 I---DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-- 3182
Query: 217 NYPAKPTLYYKDKATFG------CHDGYS--LDGPEEIECTKLGNWS-AMPSCKA-SCKV 266
L Y D G C GY+ L+G CT G WS MP+C+A +C
Sbjct: 3183 -------LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT 3235
Query: 267 PVKKATVVYQGERVKIQEKFKNGMLHGD------KVSFFCKNKEKKCSYTEDAQCI-DGT 319
P + NG L G +S+ C + + S+ C+ +GT
Sbjct: 3236 P----------------PQISNGRLEGTNFDWGFSISYIC-SPGYELSFPAVLTCVGNGT 3278
Query: 320 I--EVPKC 325
EVP+C
Sbjct: 3279 WSGEVPQC 3286
Score = 94.4 bits (233), Expect = 1e-19
Identities = 81/296 (27%), Positives = 109/296 (36%), Gaps = 68/296 (22%)
Query: 37 LKTFYEPGEEITYSCKPGY-VSRGGMRKFICPLTGLWPIN--TLKCTPRVCPFAG--ILE 91
L T Y G +TY C GY +S + +C G W + T +C CP ILE
Sbjct: 2644 LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILE 2703
Query: 92 NGAVRYTT---FEYPNTISFSCNTGFYLNGADSAKCTEEGKWS--PELPVCAPIIC---- 142
+G R +EY + FSC+ G++ G S +C G WS E P C I C
Sbjct: 2704 HGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2763
Query: 143 PPPSIPTFATLRVYKPSA------------------------------------------ 160
PP+ T Y +A
Sbjct: 2764 TPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2823
Query: 161 ------GNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDN 213
G N YRDT V++C P + G+ C NW+ +LP C V C P P
Sbjct: 2824 VNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIY 2883
Query: 214 GFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCK-ASCKVP 267
G + + D TF C+ GY + GP + +C WS P CK +C P
Sbjct: 2884 GRTSGNG---FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDP 2936
Score = 90.1 bits (222), Expect = 3e-18
Identities = 72/257 (28%), Positives = 101/257 (39%), Gaps = 22/257 (8%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP 81
TCP P + + T ++ G I+Y C PGY C G W +C P
Sbjct: 3232 TCPTPPQISNGRLEG--TNFDWGFSISYICSPGY-ELSFPAVLTCVGNGTWSGEVPQCLP 3288
Query: 82 RVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC---A 138
+ C GI G +F Y + +SFSCN F L G+ + C +G WS P C
Sbjct: 3289 KFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPT 3348
Query: 139 PIICPPPSIPTFATLRVYKPSAGNNSL---YRDTAVFECLPQHAMFGNDTITCTTHGNWT 195
C P +P + + NN+ F C H + G+ T TC W+
Sbjct: 3349 QTSCENPGVP--------RHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3400
Query: 196 KL-PECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL-DGPEEIECTKLGN 253
+ PEC C P P + V P+ Y + C G+ L G E C
Sbjct: 3401 GIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRSDNT 3458
Query: 254 WSA-MPSCKASCKVPVK 269
W+ +P C+A K+ VK
Sbjct: 3459 WTGKVPICEAGSKILVK 3475
Score = 69.7 bits (169), Expect = 4e-12
Identities = 65/259 (25%), Positives = 104/259 (40%), Gaps = 21/259 (8%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGL----WPINTLK 78
C P+ P ++ +T + + ++C G+ G +C + W
Sbjct: 2569 CSTPESPPHGYIIS-QTGGQLNSVVRWACDRGF-RLVGKSSAVCRKSSYGYHAWDAPVPA 2626
Query: 79 CTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD--SAKCTEEGKWS--PEL 134
C C NG + T + +++ CN G+ L+ + +A C +G WS +
Sbjct: 2627 CQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2686
Query: 135 PVCAPIICPPPSIPTFATLR-VYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGN 193
P C + C PSI +F ++ G++ Y+ VF C P + G +I C +G
Sbjct: 2687 PRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2744
Query: 194 WT---KLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTK 250
W+ + P C+ + C P NG N T Y A F C G+ L G EC
Sbjct: 2745 WSWRNERPYCQIISCGELPTPPNG--NKIGTQT-SYGSTAIFTCDLGFMLVGSAVRECLS 2801
Query: 251 LGNWSAMPS-CKAS-CKVP 267
G WS + C A C +P
Sbjct: 2802 SGLWSESETRCLAGHCGIP 2820
Score = 58.9 bits (141), Expect = 6e-09
Identities = 55/206 (26%), Positives = 84/206 (40%), Gaps = 29/206 (14%)
Query: 46 EITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC---TPRVCPFAGILENGAVRYTT-FE 101
E+++SC ++ G + IC G W ++ C T C G+ +G+ T F+
Sbjct: 3312 EVSFSCNFPFILVGSSTR-ICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3370
Query: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFA-TLRVYKPSA 160
+ + F C G L G+ + C + WS P C P C P P A + + PS
Sbjct: 3371 VGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH 3430
Query: 161 GNNSLYRDTAVFECLPQHAMF-GNDTITCTTHGNWT-KLPECRE-----VKCPFP----- 208
G T ++ C P + G + C + WT K+P C VK P P
Sbjct: 3431 GY------TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTP 3484
Query: 209 ----SRPDNGFV-NYPAKPTLYYKDK 229
S PD+ F NY K + +K +
Sbjct: 3485 SPKLSVPDDVFAQNYIWKGSYNFKGR 3510
Score = 45.4 bits (106), Expect = 7e-05
Identities = 59/243 (24%), Positives = 81/243 (33%), Gaps = 58/243 (23%)
Query: 74 INTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPE 133
+NT C GI +G F +T+SFSC++G+ L+ + C + WS
Sbjct: 1005 VNTYSCLD-----PGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 1059
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAV---------FECLPQHAMFGND 184
LP C + P+ L P NSL V F H +D
Sbjct: 1060 LPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHD 1119
Query: 185 TITCTTHGNWTKLPECREVKCPFPSRPDNG-------------------------FVNYP 219
+ T +G++T+ P R P + G F Y
Sbjct: 1120 YLLITENGSFTQ-PLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178
Query: 220 AKP---------------TLYYKDKATFGCHDGYSLDGPEEIECTKLGN--WSA-MPSCK 261
+P D TF C GY L+G EI C G WSA +P C
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Query: 262 ASC 264
A C
Sbjct: 1239 AEC 1241
Score = 42.0 bits (97), Expect = 8e-04
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 4/70 (5%)
Query: 77 LKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK----WSP 132
+K +CP G ENG + F +T+ FSC+ + L GA S C + WS
Sbjct: 479 IKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 538
Query: 133 ELPVCAPIIC 142
PVC C
Sbjct: 539 HRPVCKVKTC 548
Score = 38.1 bits (87), Expect = 0.012
Identities = 25/69 (36%), Positives = 30/69 (43%), Gaps = 6/69 (8%)
Query: 161 GNNSLYRDTAVFECLPQHAMFGNDTITCTTHG---NWT-KLPECREVKCPFPSRPDNGFV 216
GN+ T FEC P + + GN +TC HG NW LP C E C NG +
Sbjct: 2237 GNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRC-EALCGGNITAMNGTI 2294
Query: 217 NYPAKPTLY 225
P P Y
Sbjct: 2295 YSPGYPDEY 2303
Score = 36.6 bits (83), Expect = 0.034
Identities = 18/53 (33%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 85 PFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
P GI E F + + F C GF L G S C E +WS +P+C
Sbjct: 670 PLYGIREGDG-----FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 717
Score = 33.1 bits (74), Expect = 0.37
Identities = 58/243 (23%), Positives = 90/243 (37%), Gaps = 45/243 (18%)
Query: 42 EPGEEITYSCKPGYVSRGGMRKFICPLTG--LWPINTLKCTPRVCPFAGIL--ENGAVRY 97
EPG+ + + C PGY +G R + W + C + P G L +G +
Sbjct: 1545 EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC---IAPCGGNLTGSSGFILS 1601
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK 157
F +P S C+ +N AD +S E P + L +Y
Sbjct: 1602 PNFPHPYPHSRDCDWTITVN-ADYVISLAFISFSIE--------------PNYDFLYIYD 1646
Query: 158 PSAGNNSL---YRDTAVFECL-----PQHAMFGNDTITCTTHGNWTKLPECREVKCPFPS 209
N+ L ++D+ + E + H F +D T + + RE C P
Sbjct: 1647 GPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE-SCFDPG 1705
Query: 210 RPDNGFVNYPAKPTLYYK--DKATFGCHDGYSLDGPEEIECTKLGN-----WS-AMPSCK 261
NG + + YK T+ C GY L G + C +G+ W+ A+PSC
Sbjct: 1706 NIMNG-----TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI-MGDDGRPGWNRALPSCH 1759
Query: 262 ASC 264
A C
Sbjct: 1760 APC 1762
Score = 32.7 bits (73), Expect = 0.49
Identities = 16/58 (27%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKC----TEEGKWSPELPVC 137
C G+ G + T F+ + I +SC TG+ L+G C W +P+C
Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
Score = 32.3 bits (72), Expect = 0.64
Identities = 22/64 (34%), Positives = 26/64 (40%), Gaps = 7/64 (10%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---WS-AMPSC 260
C P P NG N + D F C GY L G E I C ++ N W + P C
Sbjct: 1528 CRDPGVPMNGTRNGDGREP---GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Query: 261 KASC 264
A C
Sbjct: 1585 IAPC 1588
Score = 32.0 bits (71), Expect = 0.83
Identities = 28/125 (22%), Positives = 45/125 (36%), Gaps = 18/125 (14%)
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
N ++ +T FY++ + ++ + C P +P T G+
Sbjct: 1499 NIVTIQFDTDFYIS---------KSGFAIQFSSSVATACRDPGVPMNGTRN------GDG 1543
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGN---WTKLPECREVKCPFPSRPDNGFVNYPA 220
DT VF+C P + + G + ITC N W P C +GF+ P
Sbjct: 1544 REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN 1603
Query: 221 KPTLY 225
P Y
Sbjct: 1604 FPHPY 1608
Score = 32.0 bits (71), Expect = 0.83
Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 3/57 (5%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVC 137
C G+ NG E +T+ F C+ G+ L G + C + W P PVC
Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Score = 32.0 bits (71), Expect = 0.83
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 6/63 (9%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT--KLGNWS-AMPSCK 261
CP P P +G D +F C GYSL G I C + W+ +P C
Sbjct: 2052 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2108
Query: 262 ASC 264
A C
Sbjct: 2109 AQC 2111
Score = 31.6 bits (70), Expect = 1.1
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 2/56 (3%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTE--EGKWSPELPVC 137
CP NG V F TISF C G+ L G + C W+ LP C
Sbjct: 2224 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2279
Score = 30.8 bits (68), Expect = 1.9
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 104 NTISFSCNTGFYLNGADSAKCT--EEGKWSPELPVC 137
+TI + CN G+ L+G+ KC E W LP C
Sbjct: 1375 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1410
Score = 28.9 bits (63), Expect = 7.0
Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 227 KDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKASC 264
+D F C G+ L G + I C + WSA +P C C
Sbjct: 683 RDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 721
Score = 28.5 bits (62), Expect = 9.2
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 8/79 (10%)
Query: 189 TTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIEC 248
+ HG E + C P P G V Y + + DK + C GY LDG ++ C
Sbjct: 162 SAHGFKVYYEELQSSSCGNPGVPPKG-VLYGTRFDV--GDKIRYSCVTGYILDGHPQLTC 218
Query: 249 ----TKLGNWS-AMPSCKA 262
+W +P C+A
Sbjct: 219 IANSVNTASWDFPVPICRA 237
Score = 28.5 bits (62), Expect = 9.2
Identities = 17/63 (26%), Positives = 25/63 (39%), Gaps = 4/63 (6%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN-WSAMPSCKAS 263
CP P P+NG F C + Y L G + I C ++ ++A +
Sbjct: 486 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 542
Query: 264 CKV 266
CKV
Sbjct: 543 CKV 545
Score = 28.5 bits (62), Expect = 9.2
Identities = 31/126 (24%), Positives = 47/126 (37%), Gaps = 21/126 (16%)
Query: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNY 218
S+GN R T+V + F + T+ + +PE R F R N F
Sbjct: 1843 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR-----FGRRIGNEFA-- 1895
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIEC----TKLGNWS-AMPSCKASCK--VPVKKA 271
F C+ GY L G I C L W+ ++P+C C + +K
Sbjct: 1896 -------VGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKG 1948
Query: 272 TVVYQG 277
T++ G
Sbjct: 1949 TILSPG 1954
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 95.9 bits (237), Expect = 5e-20
Identities = 62/225 (27%), Positives = 97/225 (43%), Gaps = 15/225 (6%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTT- 99
++PG + +SC+ G+V RG + C G W + +C C G N V ++
Sbjct: 2851 FDPGTVMRFSCEAGHVLRGSSER-TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDG 2909
Query: 100 FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPS 159
+ ++I + C G+Y G S C+ G W+ P C I C P IP LR+
Sbjct: 2910 LVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANG-LRL---- 2964
Query: 160 AGNNSLYRDTAVFECLPQHAMFGN--DTITCTTHGNWT-KLPECREVKCPFPSRPDNGFV 216
GN+ Y T ++C+P + M + ++CT W P C+ + C P NG V
Sbjct: 2965 -GNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKV 3023
Query: 217 NYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSC 260
+ T+ C +GY L P C G+W+ +P C
Sbjct: 3024 ---VGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQC 3065
Score = 90.1 bits (222), Expect = 3e-18
Identities = 66/265 (24%), Positives = 103/265 (38%), Gaps = 27/265 (10%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYP 103
G +SC GY G R C GLW + ++C C + NG + + Y
Sbjct: 2677 GATAIFSCNSGYTLVGS-RVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYR 2735
Query: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
++ + CN GF L G C ++ WS + P C + C P P + + +G++
Sbjct: 2736 GSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQM------SGDS 2789
Query: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVK---CPFPSRPDNGF-VNY 218
+ C+ + + GN T C G+WT LP C C P P +G +
Sbjct: 2790 YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGD 2849
Query: 219 PAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKA-SCKVPVKKATVVYQ 276
P + F C G+ L G E C G+WS + P C SC P
Sbjct: 2850 SFDPGTVMR----FSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNP--------- 2896
Query: 277 GERVKIQEKFKNGMLHGDKVSFFCK 301
G + F +G++ + + C+
Sbjct: 2897 GTPSNARVVFSDGLVFSSSIVYECR 2921
Score = 82.8 bits (203), Expect = 4e-16
Identities = 57/221 (25%), Positives = 88/221 (39%), Gaps = 21/221 (9%)
Query: 47 ITYSCKPGYVSRGGMRKFI-CPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNT 105
+TY C PGY+ + C W C +C ++ NG V + F + ++
Sbjct: 2974 VTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSS 3033
Query: 106 ISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSL 165
++++C G+ L+ C G W+ ELP C P+ C P +P+ R + G +
Sbjct: 3034 VTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPS----RGRREDRGFS-- 3087
Query: 166 YRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECRE---VKCPFPSRPDNGFVN---- 217
YR + F C P + G+ C + G W+ P C + C P P G N
Sbjct: 3088 YRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQG 3147
Query: 218 YPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258
Y T+ ++ C GY L G C WS P
Sbjct: 3148 YQVGSTVLFR------CQKGYLLQGSTTRTCLPNLTWSGTP 3182
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/229 (27%), Positives = 89/229 (38%), Gaps = 16/229 (6%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG----LWPINTLKCTPRVCPFAGILENG 93
+T +PG I + C GY G IC LW C C +NG
Sbjct: 2482 QTSTQPGGSIHFGCNAGY-RLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNG 2540
Query: 94 AVRYTTFEYPNTISFSCNTGFYLN-GAD-SAKCTEEGKWSPE--LPVCAPIICPPPSIPT 149
V + +SC+ G++L GA+ +A+C + G WS P C P+ CP S +
Sbjct: 2541 MVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSIS 2600
Query: 150 FATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT---KLPECREVKCP 206
R ++ ++ + C P + G I C +G W+ P CR + C
Sbjct: 2601 VEHGR-WRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCG 2659
Query: 207 FPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS 255
P NG + Y A F C+ GY+L G EC G WS
Sbjct: 2660 ELPIPPNG---HRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWS 2705
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/185 (28%), Positives = 77/185 (41%), Gaps = 20/185 (10%)
Query: 47 ITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC---TPRVCPFAGILENGAVRYTT-FEY 102
+++SC P V G R+F C G W C T C G+ + G + ++
Sbjct: 3092 VSFSCHPPLVLVGSPRRF-CQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQV 3150
Query: 103 PNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK-PSAG 161
+T+ F C G+ L G+ + C WS P C P C P PT A + PS G
Sbjct: 3151 GSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMG 3210
Query: 162 NNSLYRDTAVFECLPQHAM-FGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYP 219
T ++ C ++ G++ TC G+WT K P C EV RP +N
Sbjct: 3211 Y------TLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEV------RPSGRPINTA 3258
Query: 220 AKPTL 224
+P L
Sbjct: 3259 REPPL 3263
Score = 65.9 bits (159), Expect = 5e-11
Identities = 60/233 (25%), Positives = 87/233 (37%), Gaps = 20/233 (8%)
Query: 38 KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRV--CPFAGILENGAV 95
+T Y+ ++ C PGY G R C G W + T R+ C I NG
Sbjct: 2611 ETQYQFQAQLMLICDPGYYYTG-QRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHR 2669
Query: 96 RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRV 155
T Y T FSCN+G+ L G+ +C G WS C C P +
Sbjct: 2670 IGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHIN- 2728
Query: 156 YKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNG 214
G N YR + V++C + G C +W+ K P C V C P P +
Sbjct: 2729 -----GENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHS 2783
Query: 215 FV---NYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKAS 263
+ +Y + Y C +L G C G+W+ ++P C +
Sbjct: 2784 QMSGDSYTVGAVVRY------SCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGT 2830
Score = 55.5 bits (132), Expect = 7e-08
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query: 98 TTFEYPNTISFSCNTGFYLNGADSAKCTEEGK----WSPELPVCAPIICPPPSIPTFATL 153
T+ + +I F CN G+ L G A CT + WS +P+C + C P P +
Sbjct: 2483 TSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMV 2542
Query: 154 RVYKPSAGNNSLYRDTAVFECLPQHAMFGND-TITCTTHGNWTKL---PECREVKCPFPS 209
+ + G ++Y + + H G + T C G W+ P+C V CP S
Sbjct: 2543 FGKEYTVGTKAMYSCSEGY-----HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVS 2597
Query: 210 --RPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS---AMPSCK 261
++G + ++ + C GY G I C G WS + P+C+
Sbjct: 2598 SISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCR 2654
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/105 (28%), Positives = 48/105 (45%), Gaps = 9/105 (8%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICP-LTGLWPINTLKCTPRVC--PFAGILEN-GAVR 96
Y+ G + + C+ GY+ +G + P LT W C P C P N GA+
Sbjct: 3148 YQVGSTVLFRCQKGYLLQGSTTRTCLPNLT--WSGTPPDCVPHHCRQPETPTHANVGALD 3205
Query: 97 YTTFEYPNTISFSCNTGFYL-NGADSAKCTEEGKWSPELPVCAPI 140
+ Y T+ +SC GF L G++ C +G W+ + P+C +
Sbjct: 3206 LPSMGY--TLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEV 3248
Score = 40.0 bits (92), Expect = 0.003
Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 4/64 (6%)
Query: 83 VCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEE----GKWSPELPVCA 138
+CP GI E G + F +++ F+CN G+ L G+ C + WS PVC
Sbjct: 342 MCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCR 401
Query: 139 PIIC 142
+C
Sbjct: 402 ARMC 405
Score = 38.9 bits (89), Expect = 0.007
Identities = 56/240 (23%), Positives = 82/240 (34%), Gaps = 67/240 (27%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI--- 140
C GI NG F ++FSC++G+ L+ + +C +WS LP C +
Sbjct: 867 CLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGG 926
Query: 141 -------ICPPPSIPTFATLRVYKPSAGNNSLYRDTA-----VFECLPQHAMFGNDTITC 188
P P F P+ N + +T+ F H G+D +
Sbjct: 927 FIQGSSGTILSPGFPDF------YPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLI 980
Query: 189 TTHGNWTK-LPECREVKCPFP-------------------SRPDNGF-----------VN 217
T +G++T+ L + + P P S GF
Sbjct: 981 TENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCE 1040
Query: 218 YPAKPTLYYK--------DKATFGCHDGYSLDGPEEIECTKLGN----WSA-MPSCKASC 264
P P + D TF C GY L+G I C LG WS+ +P C A C
Sbjct: 1041 EPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITC--LGGRRRLWSSPLPRCVAEC 1098
Score = 38.1 bits (87), Expect = 0.012
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 169 TAVFECLPQHAMFGNDTITCT--THGNWT-KLPECREVKCPFPSRPDNGFVNYPAKPTLY 225
+ FECLP + + G+ +TC T+ NW LP+C EV C NG V P P+ Y
Sbjct: 2144 SVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC-EVPCGGNITSSNGTVYSPGFPSPY 2202
Score = 37.7 bits (86), Expect = 0.015
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 8/85 (9%)
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC 200
C P IP Y G+ + DT FEC P + G ITC + W+ K P C
Sbjct: 521 CGDPGIPA------YGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Query: 201 REVKCPFPSRPDNGFVNYPAKPTLY 225
C F +G V P P Y
Sbjct: 575 -VFSCFFNFTSPSGVVLSPNYPEDY 598
Score = 35.8 bits (81), Expect = 0.058
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKC----TEEGKWSPELPVC 137
C G L NG + +TF + + +SCN GF+L G C W LP C
Sbjct: 139 CGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Score = 34.7 bits (78), Expect = 0.13
Identities = 16/54 (29%), Positives = 24/54 (44%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
C GI G + F + +T+ F C F L G + C + +WS + P C
Sbjct: 521 CGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Score = 34.7 bits (78), Expect = 0.13
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 228 DKATFGCHDGYSLDGPEEIECTKLGN---WS-AMPSCKASC 264
D F C GY+L G EI C K+ N W + P+C A C
Sbjct: 1405 DSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPC 1445
Score = 33.9 bits (76), Expect = 0.22
Identities = 33/128 (25%), Positives = 46/128 (35%), Gaps = 24/128 (18%)
Query: 155 VYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECRE------------ 202
V K GNN+ R VF H+ T+ T+ W E
Sbjct: 1150 VLKVYDGNNNSARLLGVFS----HSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS 1205
Query: 203 ---VKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT--KLGNWS-A 256
+KC P P G+ + + +F C GYSL G EE+ C + W
Sbjct: 1206 FELIKCEDPGTPKFGYKVHDEGH--FAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRP 1263
Query: 257 MPSCKASC 264
+P+C A C
Sbjct: 1264 LPTCVAEC 1271
Score = 32.7 bits (73), Expect = 0.49
Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 3/61 (4%)
Query: 80 TPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTE-EGK--WSPELPV 136
T C GI +NG+ ++E ++ F C+ G+ L G+ C + E + W P P
Sbjct: 1381 TATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPT 1440
Query: 137 C 137
C
Sbjct: 1441 C 1441
Score = 32.3 bits (72), Expect = 0.64
Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 6/67 (8%)
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCT--THGNWTKLPE 199
CPPP+I A + + R + CLP + GN+ +TC T+ + P
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVR----YRCLPGFTLVGNEILTCKLGTYLQFEGPPP 2349
Query: 200 CREVKCP 206
EV CP
Sbjct: 2350 ICEVHCP 2356
Score = 32.0 bits (71), Expect = 0.83
Identities = 22/86 (25%), Positives = 32/86 (37%), Gaps = 8/86 (9%)
Query: 142 CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCT--THGNWTKLPE 199
CP P++P+ G L D F+C P +A+ G+ I+C T W P
Sbjct: 1909 CPEPAVPSNGV------KTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPP 1962
Query: 200 CREVKCPFPSRPDNGFVNYPAKPTLY 225
+C G + P P Y
Sbjct: 1963 LCIAQCGGTVEEMEGVILSPGFPGNY 1988
Score = 31.6 bits (70), Expect = 1.1
Identities = 32/132 (24%), Positives = 49/132 (37%), Gaps = 15/132 (11%)
Query: 143 PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECRE 202
P P I + LR++ S GN+ +A ++ Q + + N K +
Sbjct: 274 PAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSVLTQ 333
Query: 203 V-------KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN-- 253
V CP P P+ G F C++GY L G + I C K+ +
Sbjct: 334 VGVSQGHNMCPDPGIPERG---KRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMF 390
Query: 254 --WS-AMPSCKA 262
WS P C+A
Sbjct: 391 AAWSDHRPVCRA 402
Score = 31.6 bits (70), Expect = 1.1
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 225 YYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKASC 264
++ D F C + L G + I C K WSA P C SC
Sbjct: 538 HHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578
Score = 31.6 bits (70), Expect = 1.1
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 104 NTISFSCNTGFYLNGADSAKCT--EEGKWSPELPVC 137
+++SFSC+ G+ L G++ C E W LP C
Sbjct: 1232 SSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTC 1267
Score = 31.6 bits (70), Expect = 1.1
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 7/53 (13%)
Query: 232 FGCHDGYSLDGPEEIECT----KLGNWS-AMPSCKASC--KVPVKKATVVYQG 277
F C+ GY+L G EIEC L W+ + P+C C + ++ T++ G
Sbjct: 1759 FECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPG 1811
Score = 31.6 bits (70), Expect = 1.1
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 6/63 (9%)
Query: 205 CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT--KLGNWS-AMPSCK 261
CP P+ P NG D +F C GY+L G I C + W+ P C
Sbjct: 1909 CPEPAVPSNGV---KTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCI 1965
Query: 262 ASC 264
A C
Sbjct: 1966 AQC 1968
Score = 30.8 bits (68), Expect = 1.9
Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 2/37 (5%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRG 59
CP P+ PF+ + Y G+ +T+ C PGY G
Sbjct: 2123 CPDPE--PFANGIVRGAGYNVGQSVTFECLPGYQLTG 2157
Score = 30.4 bits (67), Expect = 2.4
Identities = 16/56 (28%), Positives = 21/56 (37%), Gaps = 2/56 (3%)
Query: 84 CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTE--EGKWSPELPVC 137
CP NG VR + +++F C G+ L G C W LP C
Sbjct: 2123 CPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC 2178
Score = 28.9 bits (63), Expect = 7.0
Identities = 13/37 (35%), Positives = 18/37 (48%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRG 59
CP P LP + VV + G+ + Y C PG+ G
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVG 2330
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 95.1 bits (235), Expect = 8e-20
Identities = 74/294 (25%), Positives = 123/294 (41%), Gaps = 24/294 (8%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL-KCTPRVCPFAGILENGAVRYT- 98
Y G + Y C+PGY S G + +C +N L KC R C G G T
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNV-IMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
Query: 99 --TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVY 156
FEY ++CN G+ L G + + + W+ ++P+C + C P + P +
Sbjct: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSS 160
Query: 157 KPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK-LPECREVKCPFPSRPDNGF 215
+ F C + + G++ + C+ G W+K P+C E+ C P +
Sbjct: 161 AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGS- 219
Query: 216 VNYPAKPTLYYKDKATF--GCHDGYSLDGPEEIECTKLGNWSAMPSC-KASCKVPVKKAT 272
P + YK+ F C+ GY + CT+ G W +PSC + SC P
Sbjct: 220 ---PISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPSCEEKSCDNP----- 270
Query: 273 VVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCID-GTIEVPKC 325
+ G+ ++ K + GD++++ C+N + A+C G I P+C
Sbjct: 271 YIPNGDYSPLRIKHRT----GDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC 320
Score = 87.4 bits (215), Expect = 2e-17
Identities = 66/250 (26%), Positives = 99/250 (39%), Gaps = 22/250 (8%)
Query: 21 RTCPKPDDLPFST-VVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW----PI- 74
R C P D PF T + +E G + Y+C GY G + C G W PI
Sbjct: 83 RPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPIC 141
Query: 75 NTLKCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPE 133
+KC P P G + + A+ + + + F CN+G+ + G + C+++G WS E
Sbjct: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE 201
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFE--CLPQHAMFGNDTITCTTH 191
P C I C P + + +Y++ F+ C + CT
Sbjct: 202 KPKCVEISCKSPDV-------INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES 254
Query: 192 GNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDG-YSLDGPEEIECTK 250
G W LP C E C P P+ + P + D+ T+ C +G Y +CT
Sbjct: 255 G-WRPLPSCEEKSCDNPYIPNGDY--SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTS 311
Query: 251 LGNWSAMPSC 260
G W P C
Sbjct: 312 TG-WIPAPRC 320
Score = 52.0 bits (123), Expect = 8e-07
Identities = 70/252 (27%), Positives = 97/252 (38%), Gaps = 31/252 (12%)
Query: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYV--SRGGMRKFICPLTGLWPINTLKC 79
+C PD + S + K Y+ E Y C GY RG +C +G P+ + C
Sbjct: 209 SCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDA---VCTESGWRPLPS--C 262
Query: 80 TPRVC--PFAGILENGAVRYTTFEYP--NTISFSCNTGFY-LNGADSAKCTEEGKWSPEL 134
+ C P+ + NG ++ + I++ C GFY ++AKCT G W P
Sbjct: 263 EEKSCDNPY---IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA- 317
Query: 135 PVCAPIICPPPSIPTFATL-----RVYKPSA-GNNSLYRDTAVFECLPQHAMFGNDTITC 188
P C C P I R Y P A G Y FE P + + D I C
Sbjct: 318 PRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET-PSGSYW--DHIHC 374
Query: 189 TTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIEC 248
T G W+ C KC FP +NG+ + + K CH GY+L +
Sbjct: 375 TQDG-WSPAVPCLR-KCYFPYL-ENGYNQNHGRKFVQGKS-IDVACHPGYALPKAQTTVT 430
Query: 249 TKLGNWSAMPSC 260
WS P C
Sbjct: 431 CMENGWSPTPRC 442
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 95.1 bits (235), Expect = 8e-20
Identities = 74/294 (25%), Positives = 123/294 (41%), Gaps = 24/294 (8%)
Query: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL-KCTPRVCPFAGILENGAVRYT- 98
Y G + Y C+PGY S G + +C +N L KC R C G G T
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNV-IMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
Query: 99 --TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVY 156
FEY ++CN G+ L G + + + W+ ++P+C + C P + P +
Sbjct: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSS 160
Query: 157 KPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK-LPECREVKCPFPSRPDNGF 215
+ F C + + G++ + C+ G W+K P+C E+ C P +
Sbjct: 161 AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGS- 219
Query: 216 VNYPAKPTLYYKDKATF--GCHDGYSLDGPEEIECTKLGNWSAMPSC-KASCKVPVKKAT 272
P + YK+ F C+ GY + CT+ G W +PSC + SC P
Sbjct: 220 ---PISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPSCEEKSCDNP----- 270
Query: 273 VVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCID-GTIEVPKC 325
+ G+ ++ K + GD++++ C+N + A+C G I P+C
Sbjct: 271 YIPNGDYSPLRIKHRT----GDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC 320
Score = 95.1 bits (235), Expect = 8e-20
Identities = 77/320 (24%), Positives = 131/320 (40%), Gaps = 29/320 (9%)
Query: 20 GRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
G C P ++ V + Y+ GEE+TY C G+ G I G + C
Sbjct: 928 GLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDG---PAIAKCLGEKWSHPPSC 984
Query: 80 TPRVCPFAGILENG---AVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPV 136
C EN + ++ ++++C T + ++GA + C +W+ P
Sbjct: 985 IKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWTGR-PT 1042
Query: 137 CAPIIC-PPPSIPT--FATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGN 193
C C PP++ + ++ K +G Y +C + MFG++ + C +GN
Sbjct: 1043 CRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRY------QCRSPYEMFGDEEVMC-LNGN 1095
Query: 194 WTKLPECREV--KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKL 251
WT+ P+C++ KC P DNG + + C + Y L+G + I C +
Sbjct: 1096 WTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RN 1154
Query: 252 GNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLH--GDKVSFFCKN--KEKKC 307
G WS P C C + + + + + ++ K + G+ V F CK +
Sbjct: 1155 GQWSEPPKCLHPCVI----SREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSR 1210
Query: 308 SYTEDAQCIDGTIEVPKCFK 327
S+T C DG +E P C K
Sbjct: 1211 SHTLRTTCWDGKLEYPTCAK 1230
Score = 90.9 bits (224), Expect = 2e-18
Identities = 79/296 (26%), Positives = 124/296 (41%), Gaps = 27/296 (9%)
Query: 22 TCPKPDDLPFSTVVPLK---TFYEPGEEITYSCKPGYVSRGGMR--KFICPLTGLWPINT 76
TC K D+P K T+++ + + Y C GY S G +C G W
Sbjct: 504 TCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSDLP 562
Query: 77 LKCTPRVCPFAGILENGAVRYTTFEYP--NTISFSCNTGFYLNGADSAKCTEEGKWSPEL 134
+ C R C I + +Y + FSC GF + G +S +C G SP+L
Sbjct: 563 I-CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDL 620
Query: 135 PVCAPII--C-PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTH 191
P+C + C PPP + K G++ + + C P+ M G + I C
Sbjct: 621 PICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVE----YYCNPRFLMKGPNKIQCVD- 675
Query: 192 GNWTKLPEC--REVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT 249
G WT LP C E C ++G+ + P YY D F C + +++ G I C
Sbjct: 676 GEWTTLPVCIVEESTCGDIPELEHGWAQL-SSPPYYYGDSVEFNCSESFTMIGHRSITCI 734
Query: 250 KLGNWSAMPSCKASCKV-PVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKE 304
G W+ +P C A K+ K + ++ E +K +++F H + + C+ KE
Sbjct: 735 H-GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFD----HNSNIRYRCRGKE 785
Score = 87.4 bits (215), Expect = 2e-17
Identities = 66/250 (26%), Positives = 99/250 (39%), Gaps = 22/250 (8%)
Query: 21 RTCPKPDDLPFST-VVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW----PI- 74
R C P D PF T + +E G + Y+C GY G + C G W PI
Sbjct: 83 RPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPIC 141
Query: 75 NTLKCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPE 133
+KC P P G + + A+ + + + F CN+G+ + G + C+++G WS E
Sbjct: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE 201
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFE--CLPQHAMFGNDTITCTTH 191
P C I C P + + +Y++ F+ C + CT
Sbjct: 202 KPKCVEISCKSPDV-------INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES 254
Query: 192 GNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDG-YSLDGPEEIECTK 250
G W LP C E C P P+ + P + D+ T+ C +G Y +CT
Sbjct: 255 G-WRPLPSCEEKSCDNPYIPNGDY--SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTS 311
Query: 251 LGNWSAMPSC 260
G W P C
Sbjct: 312 TG-WIPAPRC 320
Score = 74.3 bits (181), Expect = 1e-13
Identities = 73/313 (23%), Positives = 123/313 (39%), Gaps = 33/313 (10%)
Query: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPR 82
CP P +P S + Y GE+++ C+ Y+ + G + C G W L
Sbjct: 811 CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEG-EEITCK-DGRWQSIPLCVEKI 868
Query: 83 VCPFAGILENGAVRYT-----TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
C +E+G + + ++ + +S++C GF ++ + C GKWS P C
Sbjct: 869 PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTC-YMGKWSSP-PQC 926
Query: 138 APIIC-PPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK 196
+ C PP I + ++ Y + ++C + G C W+
Sbjct: 927 EGLPCKSPPEISHGVVAHM-----SDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSH 980
Query: 197 LPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA 256
P C + C +N K ++ T+ C Y +DG + C W+
Sbjct: 981 PPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCIN-SRWTG 1039
Query: 257 MPSCK-ASCKVP--VKKATVVYQ-------GERVKIQEKFKNGMLHGDKVSFFCKNKEKK 306
P+C+ SC P V+ A +V + GERV+ Q + M ++V C N
Sbjct: 1040 RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEV--MCLNG--- 1094
Query: 307 CSYTEDAQCIDGT 319
++TE QC D T
Sbjct: 1095 -NWTEPPQCKDST 1106
Score = 68.9 bits (167), Expect = 6e-12
Identities = 77/302 (25%), Positives = 115/302 (38%), Gaps = 34/302 (11%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTP-RVCPFAGI-LENGAVRYTTFE 101
G+ I +C PGY C G P T +C + C + I +ENG + + +
Sbjct: 409 GKSIDVACHPGYALPKAQTTVTCMENGWSP--TPRCIRVKTCSKSSIDIENGFISESQYT 466
Query: 102 YP--NTISFSCNTGFYLNGAD---SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVY 156
Y + C G+ + S C ++G WS + P C IP F R
Sbjct: 467 YALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTCIKSC----DIPVFMNARTK 520
Query: 157 KPSAGNNSLYRDTAVFECLPQHAMFGNDT---ITCTTHGNWTKLPECREVKCPFPSRPDN 213
DT +EC + T I C +G W+ LP C E +C P + D
Sbjct: 521 NDFTWFK--LNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSDLPICYERECELP-KIDV 576
Query: 214 GFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCK---ASCKVPVKK 270
V K + F C G+++ GP ++C G +P CK SC P +
Sbjct: 577 HLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPE- 635
Query: 271 ATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGT-IEVPKCFKEH 329
+ G ++EK K H + V ++C N QC+DG +P C E
Sbjct: 636 ---LLNG---NVKEKTKEEYGHSEVVEYYC-NPRFLMKGPNKIQCVDGEWTTLPVCIVEE 688
Query: 330 SS 331
S+
Sbjct: 689 ST 690
Score = 63.2 bits (152), Expect = 3e-10
Identities = 75/321 (23%), Positives = 123/321 (38%), Gaps = 38/321 (11%)
Query: 21 RTCPKPD-DLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG--MRKFICPLTGLW---PI 74
+TC K D+ + + Y E+ Y CK GYV+ G C G W P
Sbjct: 446 KTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSAQPT 504
Query: 75 NTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD---SAKCTEEGKWS 131
C V A + +T F+ +T+ + C+ G+ N S C G WS
Sbjct: 505 CIKSCDIPVFMNARTKND----FTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS 559
Query: 132 PELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTH 191
+LP+C C P I + + + + F C P + G +++ C
Sbjct: 560 -DLPICYERECELPKI----DVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHF 614
Query: 192 GNWTKLPECRE--VKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECT 249
G LP C+E C P NG V K + + + C+ + + GP +I+C
Sbjct: 615 GLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV 674
Query: 250 KLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKN----GMLHGDKVSFFCKNKEK 305
G W+ +P C V+++T G+ +++ + +GD V F C
Sbjct: 675 D-GEWTTLPVC------IVEESTC---GDIPELEHGWAQLSSPPYYYGDSVEFNCSESFT 724
Query: 306 KCSYTEDAQCIDGT-IEVPKC 325
+ CI G ++P+C
Sbjct: 725 MIGH-RSITCIHGVWTQLPQC 744
Score = 45.1 bits (105), Expect = 1e-04
Identities = 62/233 (26%), Positives = 90/233 (38%), Gaps = 34/233 (14%)
Query: 82 RVCPFAGILENGAVRY--TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAP 139
R C F LENG + F +I +C+ G+ L A + E WSP P C
Sbjct: 387 RKCYFP-YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSP-TPRCIR 444
Query: 140 I-ICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDT---ITCTTHGNWT 195
+ C SI + + ++ A ++C + +T ITC G W+
Sbjct: 445 VKTCSKSSID---IENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WS 500
Query: 196 KLPECREVKCPFP----SRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKL 251
P C + C P +R N F + TL Y+ CHDGY +
Sbjct: 501 AQPTCIK-SCDIPVFMNARTKNDFTWFKLNDTLDYE------CHDGYESNTGSTTGSIVC 553
Query: 252 G--NWSAMPSC-KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCK 301
G WS +P C + C++P K V +R K Q K G+ + F CK
Sbjct: 554 GYNGWSDLPICYERECELP--KIDVHLVPDRKKDQYKV------GEVLKFSCK 598
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 91.3 bits (225), Expect = 1e-18
Identities = 88/311 (28%), Positives = 132/311 (42%), Gaps = 35/311 (11%)
Query: 30 PFSTVVPLKTFYEPGEEITYSCKPGYVS--RGGMRKFICPLTGLWPINTLKCTPRVCPFA 87
PFS V + FY YSC+ +VS + + C G P T KC R+C F
Sbjct: 41 PFSQVPTGEVFY-------YSCEYNFVSPSKSFWTRITCTEEGWSP--TPKCL-RLC-FF 89
Query: 88 GILENGAVRYT--TFEYPNTISFSCNTGFYL-NGADSAKCTEEGKWS--PELPVCAPIIC 142
+ENG + T +T+ CNTG+ L N ++ C E G WS P+
Sbjct: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCV 148
Query: 143 PPPSIPTFATL--RVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPEC 200
PP++ L ++ K +G Y EC + MFG++ + C +GNWT+ P+C
Sbjct: 149 NPPTVQNAHILSRQMSKYPSGERVRY------ECRSPYEMFGDEEVMC-LNGNWTEPPQC 201
Query: 201 REV--KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258
++ KC P DNG + + C + Y L+G + I C + G WS P
Sbjct: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPP 260
Query: 259 SCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKN--KEKKCSYTEDAQCI 316
C C + + + ++ K K + G+ F CK + S+T C
Sbjct: 261 KCLHPC--VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
Query: 317 DGTIEVPKCFK 327
DG +E P C K
Sbjct: 319 DGKLEYPTCAK 329
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 91.3 bits (225), Expect = 1e-18
Identities = 88/311 (28%), Positives = 132/311 (42%), Gaps = 35/311 (11%)
Query: 30 PFSTVVPLKTFYEPGEEITYSCKPGYVS--RGGMRKFICPLTGLWPINTLKCTPRVCPFA 87
PFS V + FY YSC+ +VS + + C G P T KC R+C F
Sbjct: 41 PFSQVPTGEVFY-------YSCEYNFVSPSKSFWTRITCTEEGWSP--TPKCL-RLC-FF 89
Query: 88 GILENGAVRYT--TFEYPNTISFSCNTGFYL-NGADSAKCTEEGKWS--PELPVCAPIIC 142
+ENG + T +T+ CNTG+ L N ++ C E G WS P+
Sbjct: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCV 148
Query: 143 PPPSIPTFATL--RVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPEC 200
PP++ L ++ K +G Y EC + MFG++ + C +GNWT+ P+C
Sbjct: 149 NPPTVQNAHILSRQMSKYPSGERVRY------ECRSPYEMFGDEEVMC-LNGNWTEPPQC 201
Query: 201 REV--KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258
++ KC P DNG + + C + Y L+G + I C + G WS P
Sbjct: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPP 260
Query: 259 SCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKN--KEKKCSYTEDAQCI 316
C C + + + ++ K K + G+ F CK + S+T C
Sbjct: 261 KCLHPC--VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
Query: 317 DGTIEVPKCFK 327
DG +E P C K
Sbjct: 319 DGKLEYPTCAK 329
>gi|86793109 complement receptor 1 isoform S precursor [Homo
sapiens]
Length = 2489
Score = 90.5 bits (223), Expect = 2e-18
Identities = 77/307 (25%), Positives = 120/307 (39%), Gaps = 30/307 (9%)
Query: 13 LCHVAIAGRTCPKPDDLPFSTVVPLKTFYE--PGEEITYSCKPGYVSRGGMRKFICPLTG 70
L + +A C P+ LPF+ L +E G + Y C+PGY R IC
Sbjct: 33 LLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPF--SIICLKNS 90
Query: 71 LWPINTLKCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGK 129
+W +C + C NG V ++ + I +SC G+ L G+ SA C G
Sbjct: 91 VWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD 150
Query: 130 ---WSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHA------M 180
W E P+C I C +P T + + N Y + C P +
Sbjct: 151 TVIWDNETPICDRIPC---GLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFEL 207
Query: 181 FGNDTITCTTH----GNWT-KLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCH 235
G +I CT++ G W+ P+C P +NG + + + F C
Sbjct: 208 VGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQ 267
Query: 236 DGYSLDGPEEIECTKLGNWS-AMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGD 294
G+ + GP ++C L W +PSC C+ P V ER ++ K+ G
Sbjct: 268 PGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPD----VLHAERT---QRDKDNFSPGQ 320
Query: 295 KVSFFCK 301
+V + C+
Sbjct: 321 EVFYSCE 327
Score = 89.7 bits (221), Expect = 3e-18
Identities = 77/297 (25%), Positives = 120/297 (40%), Gaps = 32/297 (10%)
Query: 14 CHVAIAGRTCPKPDDLPF-STVVPLKTFYEP-GEEITYSCKPGYVSRGGMRKFICPLTGL 71
C +++ C P+ PF S +P+ F P G + Y C+PGY G M C +
Sbjct: 1837 CELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF--GKMFSISCLENLV 1894
Query: 72 WPINTLKCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGK- 129
W C + C NG V T ++ +T+++SCN GF L G+ S C G
Sbjct: 1895 WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNN 1954
Query: 130 --WSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAV-FEC------LPQHAM 180
W + P+C I C PP PT + Y S S + T V ++C +
Sbjct: 1955 VTWDKKAPICEIISCEPP--PTISNGDFY--SNNRTSFHNGTVVTYQCHTGPDGEQLFEL 2010
Query: 181 FGNDTITCTTH----GNWTK-LPECREV-KCPFPSRPDNGFVNYPAKPTLY-YKDKATFG 233
G +I CT+ G W+ P C KC P + P + + + F
Sbjct: 2011 VGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE--VENAIRVPGNRSFFTLTEIIRFR 2068
Query: 234 CHDGYSLDGPEEIECTKLGNWS-AMPSCKASCKVPVKKATVVYQGERVKIQEKFKNG 289
C G+ + G ++C G W +P C C+ P + +++ + Q+ F G
Sbjct: 2069 CQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPE---ILHGEHTLSHQDNFSPG 2122
Score = 87.8 bits (216), Expect = 1e-17
Identities = 85/305 (27%), Positives = 123/305 (40%), Gaps = 35/305 (11%)
Query: 21 RTC-PKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
R C P P+ L + + + PG+E+ YSC+P Y RG C G W +C
Sbjct: 2098 RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA-ASLHCTPQGDWSPEAPRC 2156
Query: 80 TPRVC-PFAGILENGAVRY-TTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPEL 134
T + C F G L +G V + +SF C+ GF L G ++ C G W+ +
Sbjct: 2157 TVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSV 2216
Query: 135 PVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTA-VFECLPQHAM----FGNDTITCT 189
PVC I CP P P R G+ ++ + + P M G +I CT
Sbjct: 2217 PVCEQIFCPNP--PAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCT 2274
Query: 190 T----HGNWTK-LPECR---EVKCPFPSRPDNGFVNYPAKPTLYYKDKATFG--CHDGYS 239
+ +G W+ P C CP P + NG +Y Y T C GY
Sbjct: 2275 SDPQGNGVWSSPAPRCELSVPAACPHPPKIQNG--HYIGGHVSLYLPGMTISYICDPGYL 2332
Query: 240 LDGPEEIECTKLGNWSAMPS-CK-ASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVS 297
L G I CT G WS + CK +C P+ + + E K+ +GD V+
Sbjct: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYH-------YGDYVT 2385
Query: 298 FFCKN 302
C++
Sbjct: 2386 LKCED 2390
Score = 86.3 bits (212), Expect = 4e-17
Identities = 70/234 (29%), Positives = 96/234 (41%), Gaps = 30/234 (12%)
Query: 44 GEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLKCTPRVCPFAGILENGAVRYTTF 100
G ++++ C G+ +G C L G LW + C CP + NG T F
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASH-CVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF 2240
Query: 101 ---EYPNTISFSCNTG------FYLNGADSAKCTEE----GKWSPELPVC---APIICP- 143
Y IS++C+T F L G S +CT + G WS P C P CP
Sbjct: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
Query: 144 PPSIPTFATLRVYKPSAGNNSLYRD--TAVFECLPQHAMFGNDTITCTTHGNWTKLPE-C 200
PP I + G+ SLY T + C P + + G I CT G W++L C
Sbjct: 2301 PPKIQNGHYI------GGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYC 2354
Query: 201 REVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNW 254
+EV C FP + K +Y D T C DGY+L+G +C W
Sbjct: 2355 KEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRW 2408
Score = 79.7 bits (195), Expect = 3e-15
Identities = 66/238 (27%), Positives = 93/238 (39%), Gaps = 28/238 (11%)
Query: 44 GEEITYSCKPGYVSRG-----GMRKFICPLT----GLWPINTLKCT-PRVCPFAGILENG 93
G +TY C PG R G C G+W +C P C + ENG
Sbjct: 188 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV-ENG 246
Query: 94 AV---RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTF 150
+ + F + F C GF + G KC KW PELP C+ + PPP +
Sbjct: 247 ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDV--- 303
Query: 151 ATLRVYKPSAGNNSLYRDTAVF-ECLPQHAMFGNDTITCTTHGNWT-KLPECREVKC-PF 207
L + ++ VF C P + + G ++ CT G+W+ P C C F
Sbjct: 304 --LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
Query: 208 PSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---W-SAMPSCK 261
+ NG V +P L K F C +G+ L G C G W S++P C+
Sbjct: 362 MGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 417
Score = 79.7 bits (195), Expect = 3e-15
Identities = 77/300 (25%), Positives = 115/300 (38%), Gaps = 36/300 (12%)
Query: 23 CPKPDDLPFSTVVPLKTF-----YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL 77
C PD F+ LKT + G + Y C+P Y R C +W
Sbjct: 493 CQAPDHFLFAK---LKTQTNASDFPIGTSLKYECRPEYYGRPF--SITCLDNLVWSSPKD 547
Query: 78 KCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPE 133
C + C NG V T + + I++SC TG L G SA+C G WS +
Sbjct: 548 VCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTK 607
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHA------MFGNDTIT 187
P+C I C P PT A + + N Y + C P + G +I
Sbjct: 608 PPICQRIPCGLP--PTIAN-GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIY 664
Query: 188 CTTH----GNWT-KLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDG 242
CT++ G W+ P+C P +NG + + + F C G+ + G
Sbjct: 665 CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 724
Query: 243 PEEIECTKLGNWS-AMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCK 301
P ++C L W +PSC C+ P V ER ++ K+ G +V + C+
Sbjct: 725 PRRVKCQALNKWEPELPSCSRVCQPPPD----VLHAERT---QRDKDNFSPGQEVFYSCE 777
Score = 79.7 bits (195), Expect = 3e-15
Identities = 66/238 (27%), Positives = 93/238 (39%), Gaps = 28/238 (11%)
Query: 44 GEEITYSCKPGYVSRG-----GMRKFICPLT----GLWPINTLKCT-PRVCPFAGILENG 93
G +TY C PG R G C G+W +C P C + ENG
Sbjct: 638 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV-ENG 696
Query: 94 AV---RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTF 150
+ + F + F C GF + G KC KW PELP C+ + PPP +
Sbjct: 697 ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDV--- 753
Query: 151 ATLRVYKPSAGNNSLYRDTAVF-ECLPQHAMFGNDTITCTTHGNWT-KLPECREVKC-PF 207
L + ++ VF C P + + G ++ CT G+W+ P C C F
Sbjct: 754 --LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 811
Query: 208 PSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---W-SAMPSCK 261
+ NG V +P L K F C +G+ L G C G W S++P C+
Sbjct: 812 MGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867
Score = 79.7 bits (195), Expect = 3e-15
Identities = 77/300 (25%), Positives = 115/300 (38%), Gaps = 36/300 (12%)
Query: 23 CPKPDDLPFSTVVPLKTF-----YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL 77
C PD F+ LKT + G + Y C+P Y R C +W
Sbjct: 943 CQAPDHFLFAK---LKTQTNASDFPIGTSLKYECRPEYYGRPF--SITCLDNLVWSSPKD 997
Query: 78 KCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPE 133
C + C NG V T + + I++SC TG L G SA+C G WS +
Sbjct: 998 VCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTK 1057
Query: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHA------MFGNDTIT 187
P+C I C P PT A + + N Y + C P + G +I
Sbjct: 1058 PPICQRIPCGLP--PTIAN-GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIY 1114
Query: 188 CTTH----GNWT-KLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDG 242
CT++ G W+ P+C P +NG + + + F C G+ + G
Sbjct: 1115 CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 1174
Query: 243 PEEIECTKLGNWS-AMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCK 301
P ++C L W +PSC C+ P V ER ++ K+ G +V + C+
Sbjct: 1175 PRRVKCQALNKWEPELPSCSRVCQPPPD----VLHAERT---QRDKDNFSPGQEVFYSCE 1227
Score = 79.7 bits (195), Expect = 3e-15
Identities = 66/238 (27%), Positives = 93/238 (39%), Gaps = 28/238 (11%)
Query: 44 GEEITYSCKPGYVSRG-----GMRKFICPLT----GLWPINTLKCT-PRVCPFAGILENG 93
G +TY C PG R G C G+W +C P C + ENG
Sbjct: 1088 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV-ENG 1146
Query: 94 AV---RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTF 150
+ + F + F C GF + G KC KW PELP C+ + PPP +
Sbjct: 1147 ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDV--- 1203
Query: 151 ATLRVYKPSAGNNSLYRDTAVF-ECLPQHAMFGNDTITCTTHGNWT-KLPECREVKC-PF 207
L + ++ VF C P + + G ++ CT G+W+ P C C F
Sbjct: 1204 --LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 1261
Query: 208 PSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---W-SAMPSCK 261
+ NG V +P L K F C +G+ L G C G W S++P C+
Sbjct: 1262 MGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 1317
Score = 79.3 bits (194), Expect = 5e-15
Identities = 90/335 (26%), Positives = 127/335 (37%), Gaps = 72/335 (21%)
Query: 21 RTC-PKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
R C P PD L K + PG+E+ YSC+PGY RG C G W C
Sbjct: 295 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA-ASMRCTPQGDWSPAAPTC 353
Query: 80 TPRVC-PFAGILENGAVRY-TTFEYPNTISFSCNTGFYLNGADSAKCT---EEGKWSPEL 134
+ C F G L NG V + + + F C+ GF L G+ ++ C E W+ +
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 413
Query: 135 PVCAPIICP-PPSIP----TFATLRVYKPSAGNNSLYRDTAVFECLP------QHAMFGN 183
PVC I CP PP IP T L V+ + T + C P + G
Sbjct: 414 PVCEQIFCPSPPVIPNGRHTGKPLEVFP--------FGKTVNYTCDPHPDRGTSFDLIGE 465
Query: 184 DTITCTT----HGNWTK-LPECREV-KCPFPS-------RPDNGFVNYPAKPTLYYKDKA 230
TI CT+ +G W+ P C + C P + ++P +L Y+
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE--- 522
Query: 231 TFGCHDGYSLDGPEEIECTKLGNWSAMPS-CK-ASCKVPVKKATVVYQGERVKIQEKFKN 288
C Y P I C WS+ CK SCK P N
Sbjct: 523 ---CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPV----------------N 562
Query: 289 GMLH-------GDKVSFFCKNKEKKCSYTEDAQCI 316
GM+H G ++++ C + ++ A+CI
Sbjct: 563 GMVHVITDIQVGSRINYSCTTGHRLIGHS-SAECI 596
Score = 79.3 bits (194), Expect = 5e-15
Identities = 90/335 (26%), Positives = 127/335 (37%), Gaps = 72/335 (21%)
Query: 21 RTC-PKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
R C P PD L K + PG+E+ YSC+PGY RG C G W C
Sbjct: 745 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA-ASMRCTPQGDWSPAAPTC 803
Query: 80 TPRVC-PFAGILENGAVRY-TTFEYPNTISFSCNTGFYLNGADSAKCT---EEGKWSPEL 134
+ C F G L NG V + + + F C+ GF L G+ ++ C E W+ +
Sbjct: 804 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 863
Query: 135 PVCAPIICP-PPSIP----TFATLRVYKPSAGNNSLYRDTAVFECLP------QHAMFGN 183
PVC I CP PP IP T L V+ + T + C P + G
Sbjct: 864 PVCEQIFCPSPPVIPNGRHTGKPLEVFP--------FGKTVNYTCDPHPDRGTSFDLIGE 915
Query: 184 DTITCTT----HGNWTK-LPECREV-KCPFPS-------RPDNGFVNYPAKPTLYYKDKA 230
TI CT+ +G W+ P C + C P + ++P +L Y+
Sbjct: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE--- 972
Query: 231 TFGCHDGYSLDGPEEIECTKLGNWSAMPS-CK-ASCKVPVKKATVVYQGERVKIQEKFKN 288
C Y P I C WS+ CK SCK P N
Sbjct: 973 ---CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPV----------------N 1012
Query: 289 GMLH-------GDKVSFFCKNKEKKCSYTEDAQCI 316
GM+H G ++++ C + ++ A+CI
Sbjct: 1013 GMVHVITDIQVGSRINYSCTTGHRLIGHS-SAECI 1046
Score = 79.0 bits (193), Expect = 6e-15
Identities = 66/239 (27%), Positives = 97/239 (40%), Gaps = 30/239 (12%)
Query: 44 GEEITYSCKPGYVSRG-------GMRKFICPLT----GLWPINTLKCT-PRVCPFAGILE 91
G +TY C G SRG G C G+W +C P C + E
Sbjct: 1538 GSVVTYRCNLG--SRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV-E 1594
Query: 92 NGAV---RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIP 148
NG + + F + F C GF + G KC KW PELP C+ + PPP I
Sbjct: 1595 NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEI- 1653
Query: 149 TFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKC-P 206
+ PS +N + C P + + G ++ CT G+W+ + P C C
Sbjct: 1654 ---LHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD 1710
Query: 207 FPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN---W-SAMPSCK 261
F + +G V +P L K +F C +G+ L G C +G W +++P C+
Sbjct: 1711 FLGQLPHGRVLFPL--NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCE 1767
Score = 77.8 bits (190), Expect = 1e-14
Identities = 90/335 (26%), Positives = 126/335 (37%), Gaps = 72/335 (21%)
Query: 21 RTC-PKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
R C P PD L K + PG+E+ YSC+PGY RG C G W C
Sbjct: 1195 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA-ASMRCTPQGDWSPAAPTC 1253
Query: 80 TPRVC-PFAGILENGAVRY-TTFEYPNTISFSCNTGFYLNGADSAKCT---EEGKWSPEL 134
+ C F G L NG V + + + F C+ GF L G+ ++ C E W+ +
Sbjct: 1254 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 1313
Query: 135 PVCAPIICP-PPSIP----TFATLRVYKPSAGNNSLYRDTAVFECLP------QHAMFGN 183
PVC I CP PP IP T L V+ N + C P + G
Sbjct: 1314 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVN--------YTCDPHPDRGTSFDLIGE 1365
Query: 184 DTITCTT----HGNWTK-LPECREV-KCPFPS-------RPDNGFVNYPAKPTLYYKDKA 230
TI CT+ +G W+ P C + C P + ++P +L Y+
Sbjct: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE--- 1422
Query: 231 TFGCHDGYSLDGPEEIECTKLGNWSAMPS-CK-ASCKVPVKKATVVYQGERVKIQEKFKN 288
C Y P I C WS+ CK SCK P N
Sbjct: 1423 ---CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPV----------------N 1462
Query: 289 GMLH-------GDKVSFFCKNKEKKCSYTEDAQCI 316
GM+H G ++++ C + ++ A+CI
Sbjct: 1463 GMVHVITDIQVGSRINYSCTTGHRLIGHS-SAECI 1496
Score = 76.3 bits (186), Expect = 4e-14
Identities = 71/273 (26%), Positives = 107/273 (39%), Gaps = 43/273 (15%)
Query: 23 CPKPDDLPFSTVVPLKTF-----YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL 77
C PD F+ LKT + G + Y C+P Y R C +W
Sbjct: 1393 CQAPDHFLFAK---LKTQTNASDFPIGTSLKYECRPEYYGRPF--SITCLDNLVWSSPKD 1447
Query: 78 KCTPRVCPFAGILENGAVRYTT-FEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPE 133
C + C NG V T + + I++SC TG L G SA+C G WS +
Sbjct: 1448 VCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTK 1507
Query: 134 LPVCAPIICP-PPSIPT------------FATLRVYKPSAGNNSLYRDTAVFECLPQHAM 180
P+C I C PP+I + ++ Y+ + G+ R VFE +
Sbjct: 1508 PPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGS----RGRKVFE------L 1557
Query: 181 FGNDTITCTTH----GNWT-KLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCH 235
G +I CT++ G W+ P+C P +NG + + + F C
Sbjct: 1558 VGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQ 1617
Query: 236 DGYSLDGPEEIECTKLGNWS-AMPSCKASCKVP 267
G+ + GP ++C L W +PSC C+ P
Sbjct: 1618 PGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 1650
Score = 76.3 bits (186), Expect = 4e-14
Identities = 80/278 (28%), Positives = 114/278 (41%), Gaps = 43/278 (15%)
Query: 21 RTCPKPDDLPFSTVVPL-KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC 79
R C P ++ P + + PG+E+ YSC+PGY RG C G W +C
Sbjct: 1645 RVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA-ASLHCTPQGDWSPEAPRC 1703
Query: 80 TPRVC-PFAGILENGAVRY-TTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPEL 134
+ C F G L +G V + + +SF C+ GF L G+ + C G W+ +
Sbjct: 1704 AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSV 1763
Query: 135 PVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQ------HAMFGNDTITC 188
PVC I CP P P R + + + Y + C P + G TI C
Sbjct: 1764 PVCEHIFCPNP--PAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRC 1820
Query: 189 TT--HGN--WTK-LPEC----REVKC------PF--PSRPDNGFVNYPAKPTLYYKDKAT 231
T+ HGN W+ P C R C PF P+ P N F +P +L Y+
Sbjct: 1821 TSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF-EFPVGTSLNYE---- 1875
Query: 232 FGCHDGYSLDGPEEIECTKLGNWSAM-PSC-KASCKVP 267
C GY I C + WS++ +C + SC P
Sbjct: 1876 --CRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPP 1910
Score = 75.5 bits (184), Expect = 7e-14
Identities = 68/249 (27%), Positives = 102/249 (40%), Gaps = 38/249 (15%)
Query: 38 KTFYEPGEEITYSCKPG-----YVSRGGMRKFICPL----TGLWP------INTLKCTPR 82
+T + G +TY C G G R C G+W I+T KCT
Sbjct: 1985 RTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCT-- 2042
Query: 83 VCPFAGILENGAVRY----TTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCA 138
A +EN A+R + F I F C GF + G+ + +C G+W P+LP C+
Sbjct: 2043 ----APEVEN-AIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCS 2097
Query: 139 PIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KL 197
+ PPP I + S +N + C P + + G ++ CT G+W+ +
Sbjct: 2098 RVCQPPPEI----LHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEA 2153
Query: 198 PECREVKC-PFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGN--- 253
P C C F + +G V P L K +F C +G+ L G C G
Sbjct: 2154 PRCTVKSCDDFLGQLPHGRVLLPL--NLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKAL 2211
Query: 254 W-SAMPSCK 261
W S++P C+
Sbjct: 2212 WNSSVPVCE 2220
Score = 49.3 bits (116), Expect = 5e-06
Identities = 30/104 (28%), Positives = 47/104 (45%), Gaps = 8/104 (7%)
Query: 39 TFYEPGEEITYSCKPGYVSRGGMRKFI-CPLTGLWPINTLKCTPRVCPFAGILENGAVRY 97
+ Y PG I+Y C PGY+ G + FI C G+W C C F + NG +
Sbjct: 2315 SLYLPGMTISYICDPGYLLVG--KGFIFCTDQGIWSQLDHYCKEVNCSFP-LFMNGISKE 2371
Query: 98 T----TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
+ Y + ++ C G+ L G+ ++C + +W P L C
Sbjct: 2372 LEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.458
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,326,174
Number of Sequences: 37866
Number of extensions: 833596
Number of successful extensions: 3175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1706
Number of HSP's gapped (non-prelim): 591
length of query: 345
length of database: 18,247,518
effective HSP length: 103
effective length of query: 242
effective length of database: 14,347,320
effective search space: 3472051440
effective search space used: 3472051440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.