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Search of human proteins with 150036266
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150036266 cytochrome P450, family 4, subfamily F,
polypeptide 12 [Homo sapiens]
(524 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 1087 0.0
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 916 0.0
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 916 0.0
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 893 0.0
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 848 0.0
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 847 0.0
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 679 0.0
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 408 e-114
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 399 e-111
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 397 e-110
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 395 e-110
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 383 e-106
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 380 e-105
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 280 2e-75
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su... 239 6e-63
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su... 239 6e-63
gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su... 239 6e-63
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 158 1e-38
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 157 2e-38
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 155 1e-37
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 151 1e-36
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 150 2e-36
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 135 1e-31
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 115 1e-25
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 110 4e-24
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 110 4e-24
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 101 1e-21
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 101 1e-21
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 100 6e-21
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 99 7e-21
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 1087 bits (2812), Expect = 0.0
Identities = 524/524 (100%), Positives = 524/524 (100%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF
Sbjct: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK
Sbjct: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH
Sbjct: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL
Sbjct: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID
Sbjct: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
Sbjct: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC
Sbjct: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ 524
VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ
Sbjct: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ 524
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 916 bits (2368), Expect = 0.0
Identities = 435/524 (83%), Positives = 469/524 (89%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
M LSL WLGL PVA SPWLLLLLV GSWLLAR+LAWTY FY+NCRRLQCFPQPPK+NWF
Sbjct: 1 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
WGH GL+TPTEEG+K TQ+ TY QGF +WLGP P ++LCHPD IR IT+ASAA+APK
Sbjct: 61 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK 120
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
D +F FLKPWLG+G+LLSGGDKWSRHRRMLTPAFHFNILK Y+ IFNKS NIM DKWQ
Sbjct: 121 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR 180
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LASEGS+RLDMFEHISLMTLDSLQKC+FSF+S+CQE+PSEYIA ILELSA VEKR+Q IL
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL 240
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
H DFLYYL+ DG+RF RAC LVHDFTDAVI+ERR TLPTQGIDDF K+KAKSKTLDFID
Sbjct: 241 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID 300
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLLSKDEDGK LSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQE+CRQEVQE
Sbjct: 301 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE 360
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
LLKDR+P EIEWDDLAQLPFLTMC+KESLRLHPP P ISRCCTQD VLPDGRVIPKGI C
Sbjct: 361 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC 420
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
LI+IIG+H+NPTVWPDPEVYDPFRFD EN K RSPLAFIPFSAGPRNCIGQAFAMAEMKV
Sbjct: 421 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ 524
VLAL LLHFR LP HTEPRRK ELI+RAEGGLWLRVEPL Q
Sbjct: 481 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ 524
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 916 bits (2368), Expect = 0.0
Identities = 435/524 (83%), Positives = 469/524 (89%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
M LSL WLGL PVA SPWLLLLLV GSWLLAR+LAWTY FY+NCRRLQCFPQPPK+NWF
Sbjct: 1 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
WGH GL+TPTEEG+K TQ+ TY QGF +WLGP P ++LCHPD IR IT+ASAA+APK
Sbjct: 61 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK 120
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
D +F FLKPWLG+G+LLSGGDKWSRHRRMLTPAFHFNILK Y+ IFNKS NIM DKWQ
Sbjct: 121 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR 180
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LASEGS+RLDMFEHISLMTLDSLQKC+FSF+S+CQE+PSEYIA ILELSA VEKR+Q IL
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL 240
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
H DFLYYL+ DG+RF RAC LVHDFTDAVI+ERR TLPTQGIDDF K+KAKSKTLDFID
Sbjct: 241 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID 300
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLLSKDEDGK LSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQE+CRQEVQE
Sbjct: 301 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE 360
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
LLKDR+P EIEWDDLAQLPFLTMC+KESLRLHPP P ISRCCTQD VLPDGRVIPKGI C
Sbjct: 361 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC 420
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
LI+IIG+H+NPTVWPDPEVYDPFRFD EN K RSPLAFIPFSAGPRNCIGQAFAMAEMKV
Sbjct: 421 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ 524
VLAL LLHFR LP HTEPRRK ELI+RAEGGLWLRVEPL Q
Sbjct: 481 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ 524
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 893 bits (2308), Expect = 0.0
Identities = 425/520 (81%), Positives = 460/520 (88%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
MS LSL WLGL PVA SPWLLLLLV SWLLA +LAWTYAFY+NCRRL+CFPQPP+RNWF
Sbjct: 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF 60
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
WGH G++ PTEEG++ TQ+ ATY QGF VW+GPI P + LCHPD IRS+ NASAAIAPK
Sbjct: 61 WGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPK 120
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
D F FL+PWLG+G+LLS GDKWSRHRRMLTPAFHFNILK Y+ IFN+S NIM KWQ
Sbjct: 121 DKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LASEGS+ LDMFEHISLMTLDSLQKC+FSFDSHCQE+PSEYIA ILELSALV KR IL
Sbjct: 181 LASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEIL 240
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
H+DFLYYL+ DG+RF RACRLVHDFTDAVI+ERRRTLP+QG+DDF + KAKSKTLDFID
Sbjct: 241 LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLLSKDEDGK LSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQERCRQEVQE
Sbjct: 301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
LLKDR+PKEIEWDDLA LPFLTMC+KESLRLHPP P ISR TQDIVLPDGRVIPKGI C
Sbjct: 361 LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC 420
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
LI + G HHNP VWPDPEVYDPFRFDPEN K RSPLAFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLN 520
VLAL LL FR LPDHTEPRRK EL++RAEGGLWLRVEPL+
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 520
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 848 bits (2191), Expect = 0.0
Identities = 406/519 (78%), Positives = 451/519 (86%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
MSLLSL WLGLRPVA SPWLLLL+V SWLLARILAWTYAFY+N RRL+CFPQP K+NWF
Sbjct: 1 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
GHLGL+TPTEEGL+ TQ+ ATY QGF WLGPI P I LCHPD +RS+ N S AI K
Sbjct: 61 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
D +F + LKPWLG+G+LLS GDKW HRR+LTPAFHFNILK YI IF+KSANIM KWQ
Sbjct: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LA EGS+ LD+FEHISLMTLDSLQKCIFSFDS+CQE+PSEYI I+ELSALV KR+
Sbjct: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
++ DFLY+L+ GRRFHRACRLVHDFTDAVI+ERRRTL +QG+DDF + KAKSKTLDFID
Sbjct: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLLS+D++GK LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
Sbjct: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
LLKDR+PKEIEWDDLAQLPFLTMC+KESLRLHPP P +R CTQD+VLPD RVIPKG C
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
I+I +HHNP+VWPDPEVYDPFRFDPEN++ RSP+AFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
Query: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPL 519
VLAL LL FR LPDH EPRR E+++RAE GLWLRVEPL
Sbjct: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPL 519
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 847 bits (2188), Expect = 0.0
Identities = 408/520 (78%), Positives = 448/520 (86%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
M LSL LGL P+A SPWLLLLLV SWLLARILAWTY FY+NC RL+CFPQPPKRNWF
Sbjct: 1 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF 60
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
GHLGLI +EEGL + ++ T+ W+GP + + HP I+ + A AAI PK
Sbjct: 61 LGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPK 120
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
D +F FLKPWLG+G+LLS G+KWSRHRRMLTPAFHFNILK Y+ IFN+S NIM KWQ
Sbjct: 121 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LASEGS+RLDMFEHISLMTLDSLQKC+FSFDSHCQE+PSEYIA ILELSALV KR Q IL
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL 240
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
++DFLYYL+ DG+RF RACRLVHDFTDAVI+ERRRTLP+QG+DDF + KAKSKTLDFID
Sbjct: 241 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLLSKDEDGK LSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQERCRQEVQE
Sbjct: 301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
LLKDR+PKEIEWDDLAQLPFLTMC+KESLRLHPP P +SRCCTQDIVLPDGRVIPKGI C
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 420
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
LI + G HHNP VWPDPEVYDPFRFDP+N K RSPLAFIPFSAGPRNCIGQAFAMAEMKV
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLN 520
VL L LL FR LPDHTEPRRK EL++RAEGGLWLRVEPL+
Sbjct: 481 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 520
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 679 bits (1751), Expect = 0.0
Identities = 325/520 (62%), Positives = 405/520 (77%), Gaps = 2/520 (0%)
Query: 1 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60
+ LL L R A+S LL LL LL R L +FY CRRL+CFPQPP+RNW
Sbjct: 9 LHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWL 68
Query: 61 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120
GHLG+ P E GL+D ++ VW+GP++P +VL HPD I+ + ASAAIAPK
Sbjct: 69 LGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPK 128
Query: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
D+LF FLKPWLG+G+LLS GDKWSRHRR+LTPAFHF+ILK Y+ IFN+SA+IM KW+H
Sbjct: 129 DDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRH 188
Query: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240
LA + LDMFEHISLMTLDSLQKC+FS++S+CQE+ S+YI+ I+ELSAL +R +
Sbjct: 189 LAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLH 248
Query: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300
++DF+YY S DGRRF +AC +VH FT VI+ERRR L QG + + K K + KTLDFID
Sbjct: 249 HYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFID 307
Query: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
VLLL++DEDGK LSDEDIRAEADTFMF GHDTT+SG+SW+L+NLA++PEYQE+CR+E+QE
Sbjct: 308 VLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQE 367
Query: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420
++K R+ +E+EWDDL QLPF TMC+KESLR +PP +SR CT+DI LPDGR+IPKGI C
Sbjct: 368 VMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIIC 427
Query: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
L+ I G HHNPTVWPD +VY+P+RFDP+N + RSPLA++PFSAGPRNCIGQ+FAMAE++V
Sbjct: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
Query: 481 VLALMLLHFRFLPDHT-EPRRKLELIMRAEGGLWLRVEPL 519
V+AL LL FR D T + RRK ELI+R E GLWL+VEPL
Sbjct: 488 VVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPL 527
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 408 bits (1049), Expect = e-114
Identities = 229/508 (45%), Positives = 314/508 (61%), Gaps = 22/508 (4%)
Query: 15 AMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGL 74
A S +LLLL++ + L W + LQ FP PP +W +GH+ + +E L
Sbjct: 21 AASLLILLLLLIKAVQLYLHRQWLL------KALQQFPCPPS-HWLFGHIQELQQDQE-L 72
Query: 75 KDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGE 134
+ + T+ WL + L PD ++ I S PK + RFL PW+G
Sbjct: 73 QRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGY 129
Query: 135 GILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEH 194
G+LL G W +HRRMLTPAFH++ILK Y+ + S +MLDKW+ L + S L++F+H
Sbjct: 130 GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQH 188
Query: 195 ISLMTLDSLQKCIFSFDSHCQ-ERPSE-YIATILELSALVEKRSQHILQHMDFLYYLSHD 252
+SLMTLD++ KC FS Q +R S+ YI I +L+ LV R ++ D +Y L+
Sbjct: 189 VSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248
Query: 253 GRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKA 312
GR HRAC+L H TD VI+ R+ L +G + K K + LDF+D+LLL+K E+G
Sbjct: 249 GRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK---RHLDFLDILLLAKMENGSI 305
Query: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372
LSD+D+RAE DTFMF GHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W
Sbjct: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG--ASITW 363
Query: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432
+ L Q+P+ TMC+KE+LRL+PP P I R + + PDGR +PKGI L+ I G+HHNP
Sbjct: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
Query: 433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFL 492
VWP+PEV+DPFRF P +++ AF+PFS G RNCIG+ FAM E+KV AL LL F L
Sbjct: 424 VWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELL 481
Query: 493 PDHTE-PRRKLELIMRAEGGLWLRVEPL 519
PD T P L+++++ G+ LR+ L
Sbjct: 482 PDPTRIPIPIARLVLKSKNGIHLRLRRL 509
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 399 bits (1025), Expect = e-111
Identities = 212/503 (42%), Positives = 308/503 (61%), Gaps = 16/503 (3%)
Query: 22 LLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMS 81
L+LV+G L +L + + FP PP +W +GH I T L +
Sbjct: 20 LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGHALEIQETGS-LDKVVSWA 74
Query: 82 ATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGG 141
+ +W G I F+ + PD +++ + AP +++ FL+ W+G G+L+ G
Sbjct: 75 HQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAP--DVYDFFLQ-WIGRGLLVLEG 131
Query: 142 DKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLD 201
KW +HR++LTP FH+++LK Y+ +F +S IMLDKW+ A EG S D+F + M L+
Sbjct: 132 PKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALN 190
Query: 202 SLQKCIFSF-DSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC 260
+L KC F D+ R S Y + +L+ L+++R H DF+Y+L+ GRRF RAC
Sbjct: 191 TLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 250
Query: 261 RLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRA 320
++ HD TD VIRER+ L + + +++ + LDF+D+LL ++DED LSD D+RA
Sbjct: 251 QVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDILLGARDEDDIKLSDADLRA 307
Query: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPF 380
E DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+E+L D+D +WDDL ++ +
Sbjct: 308 EVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD--FFQWDDLGKMTY 365
Query: 381 LTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVY 440
LTMC+KES RL+PP P + R ++ + DGR +P G + I +H N VWPDPEV+
Sbjct: 366 LTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 425
Query: 441 DPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE-PR 499
D RF EN+ R P AF+PFSAGPRNCIGQ FAM+EMKVV A+ LL F F D + P
Sbjct: 426 DSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPI 485
Query: 500 RKLELIMRAEGGLWLRVEPLNVG 522
+ +L++R++ G L ++PL G
Sbjct: 486 KMPQLVLRSKNGFHLHLKPLGPG 508
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 397 bits (1021), Expect = e-110
Identities = 198/478 (41%), Positives = 296/478 (61%), Gaps = 14/478 (2%)
Query: 46 RRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPD 105
R L+ FP PP +WF GH I ++ ++ ++ Y + F W+GP F + PD
Sbjct: 41 RDLRPFPAPPT-HWFLGHQKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPD 97
Query: 106 TIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYIT 165
+++ + + PK +F P LG+G+ G KW +HRR+LTP FHFNILK+YI
Sbjct: 98 YAKTLLSRTD---PKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIE 154
Query: 166 IFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSE--YIA 223
+ S +MLDKW+ + S + ++++EHI+ M+LD + KC FS +++CQ + Y
Sbjct: 155 VMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAK 214
Query: 224 TILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGI 283
I ELS ++ R +L H D ++ LS G RF + R+++ +TD +I+ER+++L
Sbjct: 215 AIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVK 274
Query: 284 DDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYN 343
D + K K DF+D++L +KDE G + SD D+ +E TF+ GHDT A+ +SW+LY
Sbjct: 275 QD---NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYC 331
Query: 344 LARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCT 403
LA +PE+QERCR+EV+ +L D I WD L ++ + TMC+KE+ RL P P ISR +
Sbjct: 332 LALNPEHQERCREEVRGILGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389
Query: 404 QDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSA 463
+ + PDG +P GIT ++ I G+HHNP VW +P+V+DP RF ENS R P A++PFSA
Sbjct: 390 KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSA 449
Query: 464 GPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRR-KLELIMRAEGGLWLRVEPLN 520
G RNCIGQ FAM E+KV +AL+LLHFR PD T P I++ + G++L ++ L+
Sbjct: 450 GSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLS 507
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 395 bits (1016), Expect = e-110
Identities = 211/504 (41%), Positives = 306/504 (60%), Gaps = 17/504 (3%)
Query: 22 LLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMS 81
L+LV+G L +L + + FP PP +W +GH I T L +
Sbjct: 20 LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGHALEIQETGS-LDKVVSWA 74
Query: 82 ATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGG 141
+ +W G I F+ + PD +++ + AP +++ FL+ W+G G+L+ G
Sbjct: 75 HQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAP--DVYDFFLQ-WIGRGLLVLEG 131
Query: 142 DKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLD 201
KW +HR++LTP FH+++LK Y+ +F +S IMLDKW+ A EG S D+F + M L+
Sbjct: 132 PKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALN 190
Query: 202 SLQKCIFSFDSHC--QERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRA 259
+L KC F R S Y + +L+ L+++R H DF+Y+L+ GRRF RA
Sbjct: 191 TLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250
Query: 260 CRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIR 319
C++ HD TD VIRER+ L + + +++ + LDF+D+LL ++DED LSD D+R
Sbjct: 251 CQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDILLGARDEDDIKLSDADLR 307
Query: 320 AEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLP 379
AE DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+E+L D+D +WDDL ++
Sbjct: 308 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD--FFQWDDLGKMT 365
Query: 380 FLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEV 439
+LTMC+KES RL+PP P + R ++ + DGR +P G + I +H N VWPDPEV
Sbjct: 366 YLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEV 425
Query: 440 YDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE-P 498
+D RF EN+ R P AF+PFSAGPRNCIGQ FAM+EMKVV A+ LL F F D + P
Sbjct: 426 FDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLP 485
Query: 499 RRKLELIMRAEGGLWLRVEPLNVG 522
+ +L++R++ G L ++PL G
Sbjct: 486 IKMPQLVLRSKNGFHLHLKPLGPG 509
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 383 bits (983), Expect = e-106
Identities = 219/503 (43%), Positives = 306/503 (60%), Gaps = 22/503 (4%)
Query: 20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQ 79
+LLLL++ + L W + LQ FP PP +W +GH+ +E L+ +
Sbjct: 26 ILLLLLIKAAQLYLHRQWLL------KALQQFPCPPS-HWLFGHIQEFQHDQE-LQRIQE 77
Query: 80 MSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLS 139
T+ W+ + L PD ++ I S PK + +FL P +G G+LL
Sbjct: 78 RVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYKFLAPRIGYGLLLL 134
Query: 140 GGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMT 199
G W +HRRMLTPAFH +ILK Y+ + S +MLDKW+ L + S L++F+H+SLMT
Sbjct: 135 NGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMT 193
Query: 200 LDSLQKCIFSFDSHCQ-ERPSE-YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFH 257
LD++ K FS Q +R S+ YI I +L++LV ++ D +Y L+ GR H
Sbjct: 194 LDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253
Query: 258 RACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDED 317
RAC+L H TD VI+ R+ L +G + K K + LDF+D+LLL+K E+G LSD+D
Sbjct: 254 RACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK---RHLDFLDILLLAKMENGSILSDKD 310
Query: 318 IRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQ 377
+RAE DTFMF GHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W+ L Q
Sbjct: 311 LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL--GDGASITWNHLDQ 368
Query: 378 LPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDP 437
+P+ TMC+KE+LRL+PP P I R + + PDGR +PKGI L+ I G+HHNP VWP+
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428
Query: 438 EVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE 497
EV+DP RF P +++ AF+PFS G RNCIG+ FAM ++KV AL LL F LPD T
Sbjct: 429 EVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTR 486
Query: 498 -PRRKLELIMRAEGGLWLRVEPL 519
P L+++++ G+ LR+ L
Sbjct: 487 IPIPMARLVLKSKNGIHLRLRRL 509
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 380 bits (976), Expect = e-105
Identities = 200/506 (39%), Positives = 308/506 (60%), Gaps = 18/506 (3%)
Query: 11 LRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPT 70
L+ + P+LLL+L+ S LL +++ R L FP PP +WF+GH P
Sbjct: 6 LQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEFY-PV 63
Query: 71 EEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKP 130
+E + ++ Y +W+GP F + PD + + PK + + L+
Sbjct: 64 KE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHKILES 119
Query: 131 WLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQ-HLASEGSSRL 189
W+G G++ G KW +HR+++ P F+ +ILK +IT+ ++S +ML+KW+ H+A +SRL
Sbjct: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQ--NSRL 177
Query: 190 DMFEHISLMTLDSLQKCIFSFDSHCQ--ERPSEYIATILELSALVEKRSQHILQHMDFLY 247
++F+H+SLMTLDS+ KC FS Q Y+ + LS + +R + L H D ++
Sbjct: 178 ELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVF 237
Query: 248 YLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD 307
S G+ F + + +H FT+ VI++R+ +L D +D + + DF+D+LL +K
Sbjct: 238 KFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLSAKS 293
Query: 308 EDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDP 367
E+ K S+ D++AE TFMF GHDTT+S +SW+LY LA++PE+Q+RCR E++ELL D
Sbjct: 294 ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS- 352
Query: 368 KEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGV 427
I W+ L+Q+P+ TMC+KE LRL+ P ISR + I PDGR +P GIT I+I +
Sbjct: 353 -SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWAL 411
Query: 428 HHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLL 487
HHNP W DP+V++P RF ENS+ P AFIPFSAG RNCIGQ FA+ E KV +AL LL
Sbjct: 412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLL 471
Query: 488 HFRFLPDHTEPRRKL-ELIMRAEGGL 512
F+ PDH+ P + + +++++++ G+
Sbjct: 472 RFKLAPDHSRPPQPVRQVVLKSKNGI 497
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 280 bits (717), Expect = 2e-75
Identities = 175/529 (33%), Positives = 287/529 (54%), Gaps = 28/529 (5%)
Query: 8 WLGLRPVAMSPW--LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLG 65
WLGL + W L + G+ L+ +L ++ ++++ P + GH
Sbjct: 5 WLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHAL 64
Query: 66 LITPTEEGLKDSTQMSATYSQGFT------VWLGPIIPFIVLCHPDTIRSITNASAAIAP 119
L+ P ++ Q Y++ + +W+GP+ P + L + + + I +S I
Sbjct: 65 LMKPDG---REFFQQIIEYTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTSSKQI-D 119
Query: 120 KDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQ 179
K +++ +FL+PWLG G+L S G+KW R+MLTP FHF IL+ ++ I N+ ANI++ K +
Sbjct: 120 KSSMY-KFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLE 178
Query: 180 -HLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP-SEYIATILELSALVEKRSQ 237
H+ E + F +I+L LD + + + Q SEY+ + +S ++ +R +
Sbjct: 179 KHINQEA---FNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIK 235
Query: 238 HILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGI---DDFFKDKAKSK 294
+D Y + +G ++ +++H FT++VI ER + D +K+K
Sbjct: 236 MPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNK 295
Query: 295 TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 354
F+D+LL D++G LS EDIR E DTFMF GHDTTA+ ++W LY L +PE Q++
Sbjct: 296 RRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKV 355
Query: 355 RQEVQELLKDRD-PKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV 413
E+ ++ D P +E DL +L +L +KE+LRL P P +R ++D + RV
Sbjct: 356 DHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRV 413
Query: 414 IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAF 473
+ KG +I +H +P +P+PE + P RF PEN++GR P A++PFSAGPRNCIGQ F
Sbjct: 414 L-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKF 472
Query: 474 AMAEMKVVLALMLLHFRFLPDHTEPRRKLE--LIMRAEGGLWLRVEPLN 520
A+ E K +L+ +L HF + LE LI+R G+W++++ N
Sbjct: 473 AVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRN 521
>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 239 bits (609), Expect = 6e-63
Identities = 114/157 (72%), Positives = 134/157 (85%)
Query: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFS 209
ML PAFHFNILK Y+ IF++S NIM KW L E ++ LDMFEH++LMTLDSLQKC+FS
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 210 FDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDA 269
FDS CQE+PSEYIA++LELS+LV KR+Q IL HMDFLYYL+HDGR FHRACRL HDF DA
Sbjct: 61 FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120
Query: 270 VIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSK 306
I+E+R TLP+QG+DDF + KAKSKTLDFIDVLL+SK
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157
>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 239 bits (609), Expect = 6e-63
Identities = 114/157 (72%), Positives = 134/157 (85%)
Query: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFS 209
ML PAFHFNILK Y+ IF++S NIM KW L E ++ LDMFEH++LMTLDSLQKC+FS
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 210 FDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDA 269
FDS CQE+PSEYIA++LELS+LV KR+Q IL HMDFLYYL+HDGR FHRACRL HDF DA
Sbjct: 61 FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120
Query: 270 VIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSK 306
I+E+R TLP+QG+DDF + KAKSKTLDFIDVLL+SK
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157
>gi|239746187 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 239 bits (609), Expect = 6e-63
Identities = 114/157 (72%), Positives = 134/157 (85%)
Query: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFS 209
ML PAFHFNILK Y+ IF++S NIM KW L E ++ LDMFEH++LMTLDSLQKC+FS
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 210 FDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDA 269
FDS CQE+PSEYIA++LELS+LV KR+Q IL HMDFLYYL+HDGR FHRACRL HDF DA
Sbjct: 61 FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120
Query: 270 VIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSK 306
I+E+R TLP+QG+DDF + KAKSKTLDFIDVLL+SK
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 158 bits (400), Expect = 1e-38
Identities = 119/440 (27%), Positives = 217/440 (49%), Gaps = 44/440 (10%)
Query: 97 PFIVLCHPDTIRSI-TNASAAIAPKDNLF--IRFLKPWLGEGILLSGGDKWSRHRRMLTP 153
P + + PD I+++ ++ F + F+K I ++ ++W R R +L+P
Sbjct: 80 PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----SAISIAEDEEWKRLRSLLSP 135
Query: 154 AFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSH 213
F LK + I + ++++ + A G + + + ++D + F +
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKDVFGAYSMDVITSTSFGVNID 194
Query: 214 CQERPSEYIATILELSALVEKRSQHILQHMDFL--YYLSHDGRRFH-------RACRLVH 264
P + VE + L DFL ++LS F C
Sbjct: 195 SLNNPQD---------PFVENTKK--LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPR 243
Query: 265 DFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRA 320
+ T+ +R+ + + ++D K + +DF+ +++ S++ E KALSD ++ A
Sbjct: 244 EVTN-FLRKSVKRMKESRLEDTQKHR-----VDFLQLMIDSQNSKETESHKALSDLELVA 297
Query: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPF 380
++ F+F G++TT+S LS+++Y LA HP+ Q++ ++E+ +L ++ P +D + Q+ +
Sbjct: 298 QSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEY 355
Query: 381 LTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVY 440
L M V E+LRL P A + R C +D+ + +G IPKG+ +I +H +P W +PE +
Sbjct: 356 LDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414
Query: 441 DPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP-DHTEPR 499
P RF +N P + PF +GPRNCIG FA+ MK+ L +L +F F P T+
Sbjct: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
Query: 500 RKLEL--IMRAEGGLWLRVE 517
KL L +++ E + L+VE
Sbjct: 475 LKLSLGGLLQPEKPVVLKVE 494
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 157 bits (397), Expect = 2e-38
Identities = 115/434 (26%), Positives = 200/434 (46%), Gaps = 35/434 (8%)
Query: 97 PFIVLCHPDTIRSI-TNASAAIAPKDNLF--IRFLKPWLGEGILLSGGDKWSRHRRMLTP 153
P + + PD I+++ ++ F + F+K I ++ ++W R R +L+P
Sbjct: 80 PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----NAISIAEDEEWKRIRSLLSP 135
Query: 154 AFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSH 213
F LK + I + ++++ + A G + + ++D + F
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKHVFGAYSMDVITSTSFGVSID 194
Query: 214 CQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRE 273
P + + +L F + ++ V
Sbjct: 195 SLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP-----------ILEALNITVFPR 243
Query: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLL------SKD-EDGKALSDEDIRAEADTFM 326
+ + T+ + + + K +D L L SKD E KALSD ++ A++ F+
Sbjct: 244 KVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303
Query: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVK 386
F G++TT+S LS+++Y LA HP+ Q++ ++E+ +L ++ P +D + QL +L M V
Sbjct: 304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVVN 361
Query: 387 ESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFD 446
E+LRL P A + R C +D+ + +G IPKG+ +I +HH+P W +PE + P RF
Sbjct: 362 ETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420
Query: 447 PENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP-DHTEPRRKLELI 505
+N P + PF +GPRNCIG FA+ MK+ L +L +F F P T+ KL
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF- 479
Query: 506 MRAEGGLWLRVEPL 519
GGL L +P+
Sbjct: 480 ----GGLLLTEKPI 489
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 155 bits (391), Expect = 1e-37
Identities = 104/404 (25%), Positives = 199/404 (49%), Gaps = 23/404 (5%)
Query: 97 PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFH 156
P +V+ PD I+++ + N +L + + ++W R R +L+PAF
Sbjct: 80 PMLVIMDPDMIKTVL-VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFT 138
Query: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216
K + I ++ ++++ + A E S +++ + T+D + +F +
Sbjct: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
Query: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC---RLVHDFTDAVIRE 273
P + ++ ++ +L + +L+ + + H +++ R
Sbjct: 198 NPQDPFLKNMKKLLKLDFLDPFLLL-ISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERM 256
Query: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGG 329
+ L KDK K + +DF ++ S++ + KALSD ++ A++ +F
Sbjct: 257 KESRL---------KDKQKHR-VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306
Query: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389
+DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+ +L M V E+L
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVNETL 364
Query: 390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPEN 449
RL P ++R C +DI + +G IPKG+ ++ I +HH+P W +PE + P RF +N
Sbjct: 365 RLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423
Query: 450 SKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP 493
+IPF AGPRNCIG FA+ +K+ + L +F F P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 151 bits (382), Expect = 1e-36
Identities = 122/448 (27%), Positives = 214/448 (47%), Gaps = 46/448 (10%)
Query: 64 LGLITPTEEGL-KDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDN 122
LG + +GL K T+ Y + + + G + P + + PD IR++ +
Sbjct: 47 LGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQL-PVLAITDPDVIRTVLVKECYSVFTNR 105
Query: 123 LFIRFLKP--WLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180
R L P ++ I L+ ++W R R +L+P F LK I + ++++ +
Sbjct: 106 ---RSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRR 162
Query: 181 LASEGS--SRLDMFEHISL---------MTLDSLQKCIFSFDSHCQERPSEYIATILELS 229
A +G + D+F S+ + +DSL F ++ L LS
Sbjct: 163 EAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS 222
Query: 230 ALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKD 289
++ + + ++ + ++ + +V R ++ L D
Sbjct: 223 IILFPFLTPVFEALNVSLFPKDT----------INFLSKSVNRMKKSRL---------ND 263
Query: 290 KAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLA 345
K K + LDF+ +++ S++ E KALSD ++ A++ F+F G++TT+S LS+ LY LA
Sbjct: 264 KQKHR-LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 322
Query: 346 RHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQD 405
HP+ Q++ ++E+ +L ++ P +D + Q+ +L M V E+LRL P A + R C +D
Sbjct: 323 THPDVQQKLQKEIDAVLPNKAPP--TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380
Query: 406 IVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGP 465
+ + +G IPKG +I +HH+P W +PE + P RF + P + PF GP
Sbjct: 381 VEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGP 438
Query: 466 RNCIGQAFAMAEMKVVLALMLLHFRFLP 493
RNCIG FA+ MK+ L +L +F F P
Sbjct: 439 RNCIGMRFALMNMKLALIRVLQNFSFKP 466
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 150 bits (380), Expect = 2e-36
Identities = 104/405 (25%), Positives = 199/405 (49%), Gaps = 24/405 (5%)
Query: 97 PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFH 156
P +V+ PD I+++ + N +L + + ++W R R +L+PAF
Sbjct: 80 PMLVIMDPDMIKTVL-VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFT 138
Query: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216
K + I ++ ++++ + A E S +++ + T+D + +F +
Sbjct: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
Query: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC---RLVHDFTDAVIRE 273
P + ++ ++ +L + +L+ + + H +++ R
Sbjct: 198 NPQDPFLKNMKKLLKLDFLDPFLLL-ISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERM 256
Query: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGG 329
+ L KDK K + +DF ++ S++ + KALSD ++ A++ +F
Sbjct: 257 KESRL---------KDKQKHR-VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306
Query: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389
+DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+ +L M V E+L
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVNETL 364
Query: 390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDP-FRFDPE 448
RL P ++R C +DI + +G IPKG+ ++ I +HH+P W +PE + P RF +
Sbjct: 365 RLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKK 423
Query: 449 NSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP 493
N +IPF AGPRNCIG FA+ +K+ + L +F F P
Sbjct: 424 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 468
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 135 bits (339), Expect = 1e-31
Identities = 129/494 (26%), Positives = 231/494 (46%), Gaps = 46/494 (9%)
Query: 16 MSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEE-GL 74
MSP LLLL + LLA L T+ + R + P PP+ ++ GHL +E G
Sbjct: 1 MSPGLLLL--GSAVLLAFGLCCTFV-HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGG 57
Query: 75 KDSTQMSATYSQGFTVWLGPIIPF-------IVLCHPDTIRSITNASAAIAPKDNLFIRF 127
+ + +++ + GP++ +++ P++++ ++ KD+ R
Sbjct: 58 RVLQDVFLDWAKKY----GPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRA 111
Query: 128 LKPWLGEGILLSG------GDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHL 181
L+ GE + G ++W + RR++ AF + L S + FN+ A +++ +
Sbjct: 112 LQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK 171
Query: 182 ASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241
A +G + + M + ++ +D L K F ++ + ++ ++L S++ L
Sbjct: 172 A-DGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA 230
Query: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301
FL R + R + ++ RR L + + D +
Sbjct: 231 K--FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK----------RGEEVPADILTQ 278
Query: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
+L K E+G A DE + TF GH+T+A+ L++ + L+R PE R + EV E+
Sbjct: 279 IL--KAEEG-AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335
Query: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCL 421
+ + + ++++DL +L +L+ +KESLRL+PPA R ++ ++ DG +P L
Sbjct: 336 IGSK--RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-DGVRVPGNTPLL 392
Query: 422 IDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVV 481
+ T + DP ++P RF P K R + PFS G R+CIGQ FA E+KVV
Sbjct: 393 FSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVV 450
Query: 482 LALML--LHFRFLP 493
+A +L L FR +P
Sbjct: 451 MAKLLQRLEFRLVP 464
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 115 bits (287), Expect = 1e-25
Identities = 84/355 (23%), Positives = 172/355 (48%), Gaps = 23/355 (6%)
Query: 97 PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFH 156
P +V+ PD I+++ + N +L + + ++W R R +L+PAF
Sbjct: 80 PMLVIMDPDMIKTVL-VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFT 138
Query: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216
K + I ++ ++++ + A E S +++ + T+D + +F +
Sbjct: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
Query: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC---RLVHDFTDAVIRE 273
P + ++ ++ +L + +L+ + + H +++ R
Sbjct: 198 NPQDPFLKNMKKLLKLDFLDPFLLL-ISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERM 256
Query: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGG 329
+ L KDK K + +DF ++ S++ + KALSD ++ A++ +F
Sbjct: 257 KESRL---------KDKQKHR-VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306
Query: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389
+DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+ +L M V E+L
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVNETL 364
Query: 390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444
RL P ++R C +DI + +G IPKG+ ++ I +HH+P W +PE + P R
Sbjct: 365 RLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 110 bits (274), Expect = 4e-24
Identities = 106/429 (24%), Positives = 188/429 (43%), Gaps = 48/429 (11%)
Query: 98 FIVLCHPDTIRSI--------TNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRR 149
FIV+ PD I+ + TN A+ + F + + +L +W R
Sbjct: 88 FIVISEPDMIKQVLVENFSNFTNRMAS-------GLEFKS--VADSVLFLRDKRWEEVRG 138
Query: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSS----------RLDMFEHISLMT 199
L AF L + + +++ +++L + A G + D+ ++ T
Sbjct: 139 ALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGT 198
Query: 200 -LDSLQKCIFSFDSHCQE-------RPS-----EYIATILELSALVEKRSQHILQHMDFL 246
+DS Q F HC+ RP + + ++ L+ ++ +++ L
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNK 258
Query: 247 YYLSHDGRRFHRACR-LVHDFTDAVIRERRRTLPTQGIDDF--FKDKAKSKTLDFIDVLL 303
+ R +A DF V+ R P G+ DF +D S
Sbjct: 259 LIRNVIALRDQQAAEERRRDFLQMVLDARHSASP-MGVQDFDIVRDVFSSTGCKPNPSRQ 317
Query: 304 LSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLK 363
+ L+ ++I +A F+ G++ + LS+ Y LA +P+ QE+ +EV ++ K
Sbjct: 318 HQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFK 376
Query: 364 DRDPKEIEWDDLAQ-LPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLI 422
++ E+ L + LP+L M + E+LR++PPA +R QD + G+ IP G +
Sbjct: 377 EKHMAP-EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEM 434
Query: 423 DIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
+ +HH+P WP PE ++P RF E + P ++PF AGPR+C+G + E+K+ L
Sbjct: 435 AVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTL 494
Query: 483 ALMLLHFRF 491
+L FRF
Sbjct: 495 LHVLHKFRF 503
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 110 bits (274), Expect = 4e-24
Identities = 106/429 (24%), Positives = 188/429 (43%), Gaps = 48/429 (11%)
Query: 98 FIVLCHPDTIRSI--------TNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRR 149
FIV+ PD I+ + TN A+ + F + + +L +W R
Sbjct: 88 FIVISEPDMIKQVLVENFSNFTNRMAS-------GLEFKS--VADSVLFLRDKRWEEVRG 138
Query: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSS----------RLDMFEHISLMT 199
L AF L + + +++ +++L + A G + D+ ++ T
Sbjct: 139 ALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGT 198
Query: 200 -LDSLQKCIFSFDSHCQE-------RPS-----EYIATILELSALVEKRSQHILQHMDFL 246
+DS Q F HC+ RP + + ++ L+ ++ +++ L
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNK 258
Query: 247 YYLSHDGRRFHRACR-LVHDFTDAVIRERRRTLPTQGIDDF--FKDKAKSKTLDFIDVLL 303
+ R +A DF V+ R P G+ DF +D S
Sbjct: 259 LIRNVIALRDQQAAEERRRDFLQMVLDARHSASP-MGVQDFDIVRDVFSSTGCKPNPSRQ 317
Query: 304 LSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLK 363
+ L+ ++I +A F+ G++ + LS+ Y LA +P+ QE+ +EV ++ K
Sbjct: 318 HQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFK 376
Query: 364 DRDPKEIEWDDLAQ-LPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLI 422
++ E+ L + LP+L M + E+LR++PPA +R QD + G+ IP G +
Sbjct: 377 EKHMAP-EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEM 434
Query: 423 DIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
+ +HH+P WP PE ++P RF E + P ++PF AGPR+C+G + E+K+ L
Sbjct: 435 AVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTL 494
Query: 483 ALMLLHFRF 491
+L FRF
Sbjct: 495 LHVLHKFRF 503
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 101 bits (252), Expect = 1e-21
Identities = 88/395 (22%), Positives = 165/395 (41%), Gaps = 28/395 (7%)
Query: 98 FIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDK-WSRHRRMLTPAFH 156
F L D + N+ ++++ R P G+G+ + + ++ML +
Sbjct: 6 FTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLN 65
Query: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216
K +++I K + W S ++FE +S + + + C+ H +E
Sbjct: 66 IAHFKQHVSIIEKETKEYFESWGE-----SGEKNVFEALSELIILTASHCL-----HGKE 115
Query: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR 276
S+ + +L A ++ H + L RR RA R + D I++RR+
Sbjct: 116 IRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRR-DRAHREIKDIFYKAIQKRRQ 174
Query: 277 TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASG 336
+ + K D + LL + +DG+ L+D+++ + G T+++
Sbjct: 175 S--------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTT 220
Query: 337 LSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAP 396
+W+ + LAR Q++C E + + + P + +D L L L C+KE+LRL PP
Sbjct: 221 SAWMGFFLARDKTLQKKCYLEQKTVCGENLPP-LTYDQLKDLNLLDRCIKETLRLRPPIM 279
Query: 397 FISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL 456
+ R + G IP G + W + ++P R+ +N
Sbjct: 280 IMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF 338
Query: 457 AFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF 491
A++PF AG CIG+ FA ++K + + ML + F
Sbjct: 339 AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 373
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 101 bits (252), Expect = 1e-21
Identities = 88/395 (22%), Positives = 165/395 (41%), Gaps = 28/395 (7%)
Query: 98 FIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDK-WSRHRRMLTPAFH 156
F L D + N+ ++++ R P G+G+ + + ++ML +
Sbjct: 111 FTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLN 170
Query: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216
K +++I K + W S ++FE +S + + + C+ H +E
Sbjct: 171 IAHFKQHVSIIEKETKEYFESWGE-----SGEKNVFEALSELIILTASHCL-----HGKE 220
Query: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR 276
S+ + +L A ++ H + L RR RA R + D I++RR+
Sbjct: 221 IRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRR-DRAHREIKDIFYKAIQKRRQ 279
Query: 277 TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASG 336
+ + K D + LL + +DG+ L+D+++ + G T+++
Sbjct: 280 S--------------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTT 325
Query: 337 LSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAP 396
+W+ + LAR Q++C E + + + P + +D L L L C+KE+LRL PP
Sbjct: 326 SAWMGFFLARDKTLQKKCYLEQKTVCGENLPP-LTYDQLKDLNLLDRCIKETLRLRPPIM 384
Query: 397 FISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL 456
+ R + G IP G + W + ++P R+ +N
Sbjct: 385 IMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF 443
Query: 457 AFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF 491
A++PF AG CIG+ FA ++K + + ML + F
Sbjct: 444 AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 99.8 bits (247), Expect = 6e-21
Identities = 69/246 (28%), Positives = 115/246 (46%), Gaps = 15/246 (6%)
Query: 283 IDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFG-----GHDTTASGL 337
I D + + DFID+ LL +E+ K S+ E ++ G G DTT + L
Sbjct: 302 IKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSL 361
Query: 338 SWVLYNLARHPEYQERCRQEVQELL-KDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAP 396
W L ++ +P+ QE+ +E++ ++ +R P D AQ+P+ + E RL P
Sbjct: 362 LWCLLYMSLNPDVQEKVHEEIERVIGANRAPS---LTDKAQMPYTEATIMEVQRLTVVVP 418
Query: 397 FISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL 456
T + + G IPKG L ++ VH +P +W PE + P RF + +
Sbjct: 419 LAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKE 478
Query: 457 AFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF-LPDHTEPRRKLELIMRAEGGLWLR 515
FIPF G R C+G+ A E+ ++ ++ F F LP+ ++ + ++ GL L
Sbjct: 479 TFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSK-----KPLLTGRFGLTLA 533
Query: 516 VEPLNV 521
P N+
Sbjct: 534 PHPFNI 539
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 99.4 bits (246), Expect = 7e-21
Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 41/387 (10%)
Query: 128 LKPWL--------GEGILLSGGDKWSRHRRMLTPAFHFNILK--SYITIFNKSANIMLD- 176
+KPW G G+L+ G+ W R R AF ++K + + NK ++ D
Sbjct: 131 IKPWKAYRDYRKEGYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADF 186
Query: 177 --KWQHLASEGSSRLDMFEHISLMTLDSLQKCIFS--FDSHCQERPSEYIATILELSALV 232
+ L E D++ ++ + +S+ ++ F + E + I+ + ++
Sbjct: 187 MGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
Query: 233 EKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAK 292
+ ++ ++ L+ + H D + + + ID+ + ++
Sbjct: 247 STFGRMMVTPVELHKSLNTKVWQDHTLA------WDTIFKSVKAC-----IDNRLEKYSQ 295
Query: 293 SKTLDFI-DVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
+ DF+ D+ ++ LS +++ A +TTA+ L W+LYNL+R+P+ Q
Sbjct: 296 QPSADFLCDIYHQNR------LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQ 349
Query: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDG 411
++ +E+Q +L + E DL +P+L C+KES+RL P PF +R + VL +
Sbjct: 350 QKLLKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE- 406
Query: 412 RVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQ 471
+PKG +++ + + + D + P R+ E K +P A +PF G R CIG+
Sbjct: 407 YALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEK-INPFAHLPFGVGKRMCIGR 465
Query: 472 AFAMAEMKVVLALMLLHFRFLPDHTEP 498
A ++ + L ++ + EP
Sbjct: 466 RLAELQLHLALCWIVRKYDIQATDNEP 492
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.141 0.454
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,641,342
Number of Sequences: 37866
Number of extensions: 994870
Number of successful extensions: 3057
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2806
Number of HSP's gapped (non-prelim): 115
length of query: 524
length of database: 18,247,518
effective HSP length: 107
effective length of query: 417
effective length of database: 14,195,856
effective search space: 5919671952
effective search space used: 5919671952
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.