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Search of human proteins with 149274643
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
(364 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149274643 solute carrier family 25, member 28 [Homo sapiens] 751 0.0
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 455 e-128
gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens] 105 8e-23
gi|7706306 solute carrier family 25, member 39 isoform b [Homo s... 101 1e-21
gi|46094065 mitochondrial carrier family protein [Homo sapiens] 100 3e-21
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 98 1e-20
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 98 1e-20
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 96 4e-20
gi|219555665 solute carrier family 25, member 39 isoform a [Homo... 96 7e-20
gi|157388989 solute carrier family 25, member 36 isoform a [Homo... 93 3e-19
gi|157388991 solute carrier family 25, member 36 isoform b [Homo... 92 6e-19
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 92 7e-19
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 92 7e-19
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 92 7e-19
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 92 7e-19
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 92 7e-19
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 92 7e-19
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 92 7e-19
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 92 7e-19
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 92 7e-19
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 91 2e-18
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 89 5e-18
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 89 5e-18
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 89 8e-18
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 88 1e-17
gi|13899342 solute carrier [Homo sapiens] 86 4e-17
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 86 7e-17
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 84 3e-16
gi|115430257 solute carrier family 25, member 26 [Homo sapiens] 84 3e-16
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 82 6e-16
>gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
Length = 364
Score = 751 bits (1940), Expect = 0.0
Identities = 364/364 (100%), Positives = 364/364 (100%)
Query: 1 MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSG 60
MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSG
Sbjct: 1 MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSG 60
Query: 61 PDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWR 120
PDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWR
Sbjct: 61 PDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWR 120
Query: 121 IIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVA 180
IIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVA
Sbjct: 121 IIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVA 180
Query: 181 TLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA 240
TLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA
Sbjct: 181 TLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA 240
Query: 241 IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH 300
IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH
Sbjct: 241 IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH 300
Query: 301 ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEW 360
ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEW
Sbjct: 301 ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEW 360
Query: 361 RAGK 364
RAGK
Sbjct: 361 RAGK 364
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 455 bits (1170), Expect = e-128
Identities = 218/328 (66%), Positives = 262/328 (79%), Gaps = 11/328 (3%)
Query: 36 GVGRGAGGGEAGACRPPVRQDPDSGPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDC 95
G R GGG+ D DYE LP A+V+THM AGA+AGILEH VMYP+D
Sbjct: 19 GDSRDGGGGK----------DATGSEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDS 68
Query: 96 VKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKL 155
VKTRMQSL PDP A+Y ++ AL +I+RTEG WRP+RG+NV GAGPAHA+YFACYE +
Sbjct: 69 VKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENM 128
Query: 156 KKTLSDVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAV 215
K+TL+DV H GNSH+ANG AG +ATLLHDA MNPAEVVKQR+QMYNS + C+R V
Sbjct: 129 KRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTV 188
Query: 216 WQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVA 275
W+ EG GAFYRSYTTQLTMN+PFQ+IHF+TYEFLQE NP R YNP SH++SG AGA+A
Sbjct: 189 WRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIISGGLAGALA 248
Query: 276 AAATTPLDVCKTLLNTQESLALN-SHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
AAATTPLDVCKTLLNTQE++AL+ ++I+G ++GMA+AFRTVYQ+ G+ YF+G+QARVIY
Sbjct: 249 AAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIY 308
Query: 335 QIPSTAIAWSVYEFFKYLITKRQEEWRA 362
Q+PSTAI+WSVYEFFKY +TKRQ E RA
Sbjct: 309 QMPSTAISWSVYEFFKYFLTKRQLENRA 336
>gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens]
Length = 321
Score = 105 bits (261), Expect = 8e-23
Identities = 90/320 (28%), Positives = 137/320 (42%), Gaps = 48/320 (15%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQ---------------------PDPAARYRN 113
H+ AG G + P++ +KTR+QS + P +
Sbjct: 14 HLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPG 73
Query: 114 VLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIAN 173
+ + L I+ EG RGL G P+ A+YFACY K K+ + + P NS+I +
Sbjct: 74 LFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVP--NSNIVH 131
Query: 174 GAAGCVATLLHDAAMNPAEVVKQRMQMYN----SPYHRVTDCVRAVWQNEGAGAFYRSYT 229
+ A + ++ MNP +VK RMQ+ S C R V+Q EG FYR T
Sbjct: 132 IFSAGSAAFITNSLMNPIWMVKTRMQLEQKVRGSKQMNTLQCARYVYQTEGIRGFYRGLT 191
Query: 230 TQLTMNVPFQAIHFMTYEFLQEHFN--PQRRYNPSSHVLSGACAGAVAAAATT------- 280
+ I F YE L+++ P + S + G +AAAA +
Sbjct: 192 ASYA-GISETIICFAIYESLKKYLKEAPLASSANGTEKNSTSFFGLMAAAALSKGCASCI 250
Query: 281 --PLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPS 338
P +V +T L +E S + R V++ G A++RG+ A++I QIP+
Sbjct: 251 AYPHEVIRTRLR-EEGTKYKSFV--------QTARLVFREEGYLAFYRGLFAQLIRQIPN 301
Query: 339 TAIAWSVYEFFKYLITKRQE 358
TAI S YE YL+ R +
Sbjct: 302 TAIVLSTYELIVYLLEDRTQ 321
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/108 (26%), Positives = 49/108 (45%), Gaps = 18/108 (16%)
Query: 256 QRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNS------HI-------- 301
Q++ N H+ +G C G V A T PL+V KT L + LAL + H+
Sbjct: 6 QQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSR-LALRTVYYPQVHLGTISGAGM 64
Query: 302 ---TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVY 346
T G+ +++ + G + FRG+ ++ PS A+ ++ Y
Sbjct: 65 VRPTSVTPGLFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACY 112
>gi|7706306 solute carrier family 25, member 39 isoform b [Homo
sapiens]
Length = 351
Score = 101 bits (251), Expect = 1e-21
Identities = 87/352 (24%), Positives = 137/352 (38%), Gaps = 70/352 (19%)
Query: 67 PAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAA----------------- 109
PAG + MVA ++ M P+D VK R+QS +P A+
Sbjct: 6 PAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLSYTKWK 65
Query: 110 -----------------------------RYRNVLEALWRIIRTEGLWRPMRGLNVTATG 140
R+ ++A +I+R EG GL T
Sbjct: 66 CLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLPATLVM 125
Query: 141 AGPAHALYFACYEKLKKTL------SDVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVV 194
PA A+YF Y++LK L SD+ P AG +A L ++P E++
Sbjct: 126 TVPATAIYFTAYDQLKAFLCGRALTSDLYAPM--------VAGALARLGTVTVISPLELM 177
Query: 195 KQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQ---E 251
+ ++Q + Y + CVR G + + + +VPF A+++ YE ++
Sbjct: 178 RTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLN 237
Query: 252 HFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKT----LLNTQESLALNSHITGHITG 307
F P+ + + ++G +G VAA T P DV KT L E++ +N H+
Sbjct: 238 GFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPL---HVDS 294
Query: 308 MASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEE 359
R + G F G R+I PS AI S YEF K + ++
Sbjct: 295 TWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQD 346
>gi|46094065 mitochondrial carrier family protein [Homo sapiens]
Length = 338
Score = 99.8 bits (247), Expect = 3e-21
Identities = 86/326 (26%), Positives = 138/326 (42%), Gaps = 48/326 (14%)
Query: 71 TVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAAR-------------------- 110
T M+A IL ++ P+D VK R+Q+ Q +P +
Sbjct: 14 TPLQQMLASCTGAILTSVIVTPLDVVKIRLQA-QNNPLPKGKCFVYSNGLMDHLCVCEEG 72
Query: 111 -----------YRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTL 159
++ L+A ++IIR EG+ GL T A PA +YF CY++L L
Sbjct: 73 GNKLWYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALL 132
Query: 160 SDVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNE 219
+ G N AG VA ++P E+++ +MQ Y + V +
Sbjct: 133 RSKL--GENETCIPIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSED 190
Query: 220 GAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHF-NPQRRYNPSSHV--LSGACAGAVAA 276
G + +R + + +VPF A+++ YE L++ Y P+ + SGA +G+ AA
Sbjct: 191 GWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAA 250
Query: 277 AATTPLDVCKTLLNTQ------ESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQA 330
AT P DV KT TQ +++ H++ I + + G + F G+
Sbjct: 251 VATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWI-----IMKNIVAKNGFSGLFSGLIP 305
Query: 331 RVIYQIPSTAIAWSVYEFFKYLITKR 356
R+I P+ AI S YEF K K+
Sbjct: 306 RLIKIAPACAIMISTYEFGKAFFQKQ 331
Score = 32.0 bits (71), Expect = 0.89
Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 26/117 (22%)
Query: 269 ACAGAVAAAA-TTPLDVCKTLLNTQE-----------SLALNSHI--------------T 302
+C GA+ + TPLDV K L Q S L H+
Sbjct: 22 SCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKLWYKKP 81
Query: 303 GHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEE 359
G+ G AF + + G+ + + G+ ++ +P+T I ++ Y+ L+ + E
Sbjct: 82 GNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKLGE 138
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 97.8 bits (242), Expect = 1e-20
Identities = 77/279 (27%), Positives = 122/279 (43%), Gaps = 16/279 (5%)
Query: 79 GAVAGILEHCVMYPIDCVKTRMQSLQPDPA----ARYRNVLEALWRIIRTEGLWRPMRGL 134
G+VAG + +YPID VKTRMQ+ + + Y+N + +++R EG + RGL
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394
Query: 135 NVTATGAGPAHALYFACYEKLKKTL--SDVIHPGGNSHIANGAAGCVATLLHDAAMNPAE 192
G P A+ + ++ D P +A G AG + NP E
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIF----TNPLE 450
Query: 193 VVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEH 252
+VK R+Q+ +V ++ G Y+ ++PF AI+F Y ++
Sbjct: 451 IVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKAS 510
Query: 253 F-NPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASA 311
F N + +P S +L+GA AG AA+ TP DV KT L ++ +G+
Sbjct: 511 FANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTY-----SGVIDC 565
Query: 312 FRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
FR + + G A ++G ARV P + YE +
Sbjct: 566 FRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQ 604
Score = 58.5 bits (140), Expect = 9e-09
Identities = 45/189 (23%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 72 VTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPM 131
+ ++AG AG + P++ VK R+Q + L ++R G +
Sbjct: 428 LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALS----VVRDLGFFGIY 483
Query: 132 RGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGA---AGCVATLLHDAAM 188
+G P A+YF CY +K + ++ + ++ G+ AG +A + + +
Sbjct: 484 KGAKACFLRDIPFSAIYFPCYAHVKASFANE-----DGQVSPGSLLLAGAIAGMPAASLV 538
Query: 189 NPAEVVKQRMQMY----NSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFM 244
PA+V+K R+Q+ + Y V DC R + + EG A ++ ++ + P + +
Sbjct: 539 TPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLL 598
Query: 245 TYEFLQEHF 253
TYE LQ F
Sbjct: 599 TYELLQRWF 607
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 97.8 bits (242), Expect = 1e-20
Identities = 77/279 (27%), Positives = 122/279 (43%), Gaps = 16/279 (5%)
Query: 79 GAVAGILEHCVMYPIDCVKTRMQSLQPDPA----ARYRNVLEALWRIIRTEGLWRPMRGL 134
G+VAG + +YPID VKTRMQ+ + + Y+N + +++R EG + RGL
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 395
Query: 135 NVTATGAGPAHALYFACYEKLKKTL--SDVIHPGGNSHIANGAAGCVATLLHDAAMNPAE 192
G P A+ + ++ D P +A G AG + NP E
Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIF----TNPLE 451
Query: 193 VVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEH 252
+VK R+Q+ +V ++ G Y+ ++PF AI+F Y ++
Sbjct: 452 IVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKAS 511
Query: 253 F-NPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASA 311
F N + +P S +L+GA AG AA+ TP DV KT L ++ +G+
Sbjct: 512 FANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTY-----SGVIDC 566
Query: 312 FRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
FR + + G A ++G ARV P + YE +
Sbjct: 567 FRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQ 605
Score = 58.5 bits (140), Expect = 9e-09
Identities = 45/189 (23%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 72 VTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPM 131
+ ++AG AG + P++ VK R+Q + L ++R G +
Sbjct: 429 LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALS----VVRDLGFFGIY 484
Query: 132 RGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGA---AGCVATLLHDAAM 188
+G P A+YF CY +K + ++ + ++ G+ AG +A + + +
Sbjct: 485 KGAKACFLRDIPFSAIYFPCYAHVKASFANE-----DGQVSPGSLLLAGAIAGMPAASLV 539
Query: 189 NPAEVVKQRMQMY----NSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFM 244
PA+V+K R+Q+ + Y V DC R + + EG A ++ ++ + P + +
Sbjct: 540 TPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLL 599
Query: 245 TYEFLQEHF 253
TYE LQ F
Sbjct: 600 TYELLQRWF 608
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 96.3 bits (238), Expect = 4e-20
Identities = 73/302 (24%), Positives = 128/302 (42%), Gaps = 17/302 (5%)
Query: 50 RPPVRQDPDSGPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQP-DPA 108
RP + Q D G E L + + G+++G + P+D +KTR+Q+LQP D
Sbjct: 6 RPSLLQPQDVGDTVETLMLHPVIKAFL-CGSISGTCSTLLFQPLDLLKTRLQTLQPSDHG 64
Query: 109 ARYRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGN 168
+R +L L +++RTE L +G++ + P +YF LK+ P
Sbjct: 65 SRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTAL 124
Query: 169 SHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSY 228
+ G + + M+P V+K R + Y + +R+++ +EG +
Sbjct: 125 ESVMLGVG---SRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGL 181
Query: 229 TTQLTMNVPFQAIHFMTY---EFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVC 285
T L + PF I+ M Y + + H P ++ G AG +A+ T P DV
Sbjct: 182 TATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVI 241
Query: 286 KTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSV 345
KT + + A +++ G+ +F+G R + + A+AW+V
Sbjct: 242 KTHMQLYPL---------KFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTV 292
Query: 346 YE 347
YE
Sbjct: 293 YE 294
Score = 39.3 bits (90), Expect = 0.006
Identities = 40/201 (19%), Positives = 78/201 (38%), Gaps = 18/201 (8%)
Query: 162 VIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHR-----VTDCVRAVW 216
++HP + + +G +TLL P +++K R+Q H + + V
Sbjct: 23 MLHPVIKAFLCGSISGTCSTLL----FQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVV 78
Query: 217 QNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAA 276
+ E ++ + + VP I+F T L+++F V+ G + +VA
Sbjct: 79 RTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAG 138
Query: 277 AATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQI 336
+P+ V KT + + + +A R++Y G F G+ A ++
Sbjct: 139 VCMSPITVIKTRYESGKY---------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDA 189
Query: 337 PSTAIAWSVYEFFKYLITKRQ 357
P + I Y K ++ Q
Sbjct: 190 PFSGIYLMFYNQTKNIVPHDQ 210
>gi|219555665 solute carrier family 25, member 39 isoform a [Homo
sapiens]
Length = 359
Score = 95.5 bits (236), Expect = 7e-20
Identities = 89/361 (24%), Positives = 138/361 (38%), Gaps = 80/361 (22%)
Query: 67 PAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQS------------------------ 102
PAG + MVA ++ M P+D VK R+QS
Sbjct: 6 PAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLSYTKLP 65
Query: 103 ----------------LQP---------------DPAARYRNVLEALWRIIRTEGLWRPM 131
L+P DP R+ ++A +I+R EG
Sbjct: 66 SSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPT-RFTGTMDAFVKIVRHEGTRTLW 124
Query: 132 RGLNVTATGAGPAHALYFACYEKLKKTL------SDVIHPGGNSHIANGAAGCVATLLHD 185
GL T PA A+YF Y++LK L SD+ P AG +A L
Sbjct: 125 SGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPM--------VAGALARLGTV 176
Query: 186 AAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMT 245
++P E+++ ++Q + Y + CVR G + + + +VPF A+++
Sbjct: 177 TVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFN 236
Query: 246 YEFLQ---EHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKT----LLNTQESLALN 298
YE ++ F P+ + + ++G +G VAA T P DV KT L E++ +N
Sbjct: 237 YELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVN 296
Query: 299 SHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQE 358
H+ R + G F G R+I PS AI S YEF K + +
Sbjct: 297 PL---HVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQ 353
Query: 359 E 359
+
Sbjct: 354 D 354
>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
sapiens]
Length = 311
Score = 93.2 bits (230), Expect = 3e-19
Identities = 87/308 (28%), Positives = 130/308 (42%), Gaps = 36/308 (11%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQS-----------LQPDPAARYRNV-----LEAL 118
H+ AG G + + P++ VKTR+QS L A V L L
Sbjct: 9 HLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCL 68
Query: 119 WRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNS-HIANGA-A 176
I+ EG RGL G P+ A+YFA Y K+ L+DV P H+ + A A
Sbjct: 69 KVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMA 128
Query: 177 GCVATLLHDAAMNPAEVVKQRMQM--YNSPYHRV--TDCVRAVWQNEGAGAFYRSYTTQL 232
G A A NP ++K R+Q+ N R+ +CVR V+Q +G FYR +
Sbjct: 129 GFTAI----TATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASY 184
Query: 233 TMNVPFQAIHFMTYEFLQ----EHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTL 288
+ IHF+ YE ++ E+ N V + + AA T T+
Sbjct: 185 A-GISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTI 243
Query: 289 LNTQESLALNSHITGHITGMASAFRT---VYQVGGVTAYFRGVQARVIYQIPSTAIAWSV 345
E + + + T S F+T + Q G + +RG+ ++ QIP+TAI +
Sbjct: 244 AYPHE--VVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMAT 301
Query: 346 YEFFKYLI 353
YE YL+
Sbjct: 302 YELVVYLL 309
Score = 35.8 bits (81), Expect = 0.062
Identities = 23/92 (25%), Positives = 41/92 (44%), Gaps = 4/92 (4%)
Query: 62 DYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRI 121
D E++ + M+A A + + YP + V+TR++ + +YR+ + L +
Sbjct: 216 DEESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLR----EEGTKYRSFFQTLSLL 271
Query: 122 IRTEGLWRPMRGLNVTATGAGPAHALYFACYE 153
++ EG RGL P A+ A YE
Sbjct: 272 VQEEGYGSLYRGLTTHLVRQIPNTAIMMATYE 303
>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
sapiens]
Length = 310
Score = 92.4 bits (228), Expect = 6e-19
Identities = 89/309 (28%), Positives = 133/309 (43%), Gaps = 39/309 (12%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQS-----------LQPDPAARYRNV-----LEAL 118
H+ AG G + + P++ VKTR+QS L A V L L
Sbjct: 9 HLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCL 68
Query: 119 WRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNS-HIANGA-A 176
I+ EG RGL G P+ A+YFA Y K+ L+DV P H+ + A A
Sbjct: 69 KVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMA 128
Query: 177 GCVATLLHDAAMNPAEVVKQRMQM--YNSPYHRV--TDCVRAVWQNEGAGAFYRSYTTQL 232
G A A NP ++K R+Q+ N R+ +CVR V+Q +G FYR +
Sbjct: 129 GFTAI----TATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASY 184
Query: 233 TMNVPFQAIHFMTYEFLQ----EHFNPQRRYNPSSHVLSGA-CAGAVAAAATTPLDVCKT 287
+ IHF+ YE ++ E+ N V + G + AAAT+ C T
Sbjct: 185 A-GISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATS--KTCAT 241
Query: 288 LLNTQESLALNSHITGHITGMASAFRT---VYQVGGVTAYFRGVQARVIYQIPSTAIAWS 344
+ + + + T S F+T + Q G + +RG+ ++ QIP+TAI +
Sbjct: 242 TIAYPH--VVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMA 299
Query: 345 VYEFFKYLI 353
YE YL+
Sbjct: 300 TYELVVYLL 308
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 29/289 (10%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRN--VLEALWRIIRTEGLWRPMR 132
H+VAG AG + P+D +K MQ A+R N ++ ++IR G R
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRSNNMGIVGGFTQMIREGGARSLWR 244
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDV-----IHPGGNSHIANGAAGCVATLLHDAA 187
G + P A+ F YE++K+ + IH +A AG +A ++
Sbjct: 245 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIH---ERLVAGSLAGAIA----QSS 297
Query: 188 MNPAEVVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
+ P EV+K RM + + Y + DC R + EG AFY+ Y + +P+ I Y
Sbjct: 298 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357
Query: 247 EFLQEHFNPQRRYN---PSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHI 301
E L+ + N P VL G + A+ PL + +T + Q S+ +
Sbjct: 358 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEV 417
Query: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
T M+S F+ + + G +RG+ + IP+ +I++ VYE K
Sbjct: 418 T-----MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 60 GPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALW 119
G D E L + +VAG++AG + +YP++ +KTRM + +Y +L+
Sbjct: 272 GSDQETL----RIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRK---TGQYSGMLDCAR 324
Query: 120 RIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSD--VIHPGGNSHIANGAAG 177
RI+ EG+ +G G P + A YE LK ++ A G
Sbjct: 325 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACG 384
Query: 178 CVATLLHDAAMNPAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLT 233
+++ A P +V+ RMQ S P ++ + + + EGA YR
Sbjct: 385 TMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFM 444
Query: 234 MNVPFQAIHFMTYEFLQEHFNPQRR 258
+P +I ++ YE L+ Q R
Sbjct: 445 KVIPAVSISYVVYENLKITLGVQSR 469
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
H+++G AGAV+ T PLD K L+ S + N I G T M + GG +
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMI-------REGGARS 241
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWR 361
+RG V+ P +AI + YE K L+ QE R
Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLR 279
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 29/289 (10%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRN--VLEALWRIIRTEGLWRPMR 132
H+VAG AG + P+D +K MQ A+R N ++ ++IR G R
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRSNNMGIVGGFTQMIREGGARSLWR 278
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDV-----IHPGGNSHIANGAAGCVATLLHDAA 187
G + P A+ F YE++K+ + IH +A AG +A ++
Sbjct: 279 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIH---ERLVAGSLAGAIA----QSS 331
Query: 188 MNPAEVVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
+ P EV+K RM + + Y + DC R + EG AFY+ Y + +P+ I Y
Sbjct: 332 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 391
Query: 247 EFLQEHFNPQRRYN---PSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHI 301
E L+ + N P VL G + A+ PL + +T + Q S+ +
Sbjct: 392 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEV 451
Query: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
T M+S F+ + + G +RG+ + IP+ +I++ VYE K
Sbjct: 452 T-----MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 60 GPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALW 119
G D E L + +VAG++AG + +YP++ +KTRM + +Y +L+
Sbjct: 306 GSDQETL----RIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRK---TGQYSGMLDCAR 358
Query: 120 RIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSD--VIHPGGNSHIANGAAG 177
RI+ EG+ +G G P + A YE LK ++ A G
Sbjct: 359 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACG 418
Query: 178 CVATLLHDAAMNPAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLT 233
+++ A P +V+ RMQ S P ++ + + + EGA YR
Sbjct: 419 TMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFM 478
Query: 234 MNVPFQAIHFMTYEFLQEHFNPQRR 258
+P +I ++ YE L+ Q R
Sbjct: 479 KVIPAVSISYVVYENLKITLGVQSR 503
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
H+++G AGAV+ T PLD K L+ S + N I G T M + GG +
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMI-------REGGARS 275
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWR 361
+RG V+ P +AI + YE K L+ QE R
Sbjct: 276 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLR 313
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 92.0 bits (227), Expect = 7e-19
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 40/315 (12%)
Query: 63 YEALPAGATVTTHMVA--GAVAGILEHCVMYPIDCVKTRMQ-----SLQPDPAARYRNVL 115
Y+ P G T VA G+V+G++ ++ P D +K R Q + DP+A+Y +L
Sbjct: 4 YDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGIL 63
Query: 116 EALWRIIRTEG---LWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG----- 167
+A +I++ EG W+ + + G G L F + L++++H G
Sbjct: 64 QASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSF-------EMLTELVHRGSVYDAR 116
Query: 168 --NSH-IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSP--YHRVTDCVRAVWQNEGAG 222
+ H + G A C+ATL ++P +V++ R P Y+ + V ++++EG
Sbjct: 117 EFSVHFVCGGLAACMATL----TVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQ 172
Query: 223 AFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFN-----PQRRYNPSSHVLSGACAGAVAAA 277
FY+ L P+ + F Y L+ + ++ ++L G+ AG ++
Sbjct: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
Query: 278 ATTPLDVCKTLLNT---QESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
T PLD+ K L + + A + + G+ + V Q G +F+G+ ++
Sbjct: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRY-KGLMDCAKQVLQKEGALGFFKGLSPSLLK 291
Query: 335 QIPSTAIAWSVYEFF 349
ST + YEFF
Sbjct: 292 AALSTGFMFFSYEFF 306
Score = 67.4 bits (163), Expect = 2e-11
Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 168 NSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYN---------SPYHRVTDCVRAVWQN 218
N+ AG V+ L+ A ++P +V+K R Q+ + + YH + R + Q
Sbjct: 13 NTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQE 72
Query: 219 EGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNP---SSHVLSGACAGAVA 275
EG AF++ + +++ + A+ F+++E L E + Y+ S H + G A +A
Sbjct: 73 EGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMA 132
Query: 276 AAATTPLDVCKTLLNTQ-ESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
P+DV +T Q E N+ + A T+Y+ G +++G+ +I
Sbjct: 133 TLTVHPVDVLRTRFAAQGEPKVYNT--------LRHAVGTMYRSEGPQVFYKGLAPTLIA 184
Query: 335 QIPSTAIAWSVYEFFKYL 352
P + +S Y K+L
Sbjct: 185 IFPYAGLQFSCYSSLKHL 202
Score = 65.9 bits (159), Expect = 6e-11
Identities = 51/199 (25%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 73 TTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMR 132
+ H V G +A + ++P+D ++TR + Q +P Y + A+ + R+EG +
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAA-QGEPKV-YNTLRHAVGTMYRSEGPQVFYK 176
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG--NSHIANGAAGCVATLLHDAAMNP 190
GL T P L F+CY LK I G N ++ N G A ++ P
Sbjct: 177 GLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYP 236
Query: 191 AEVVKQRMQMYNSPYHRVT-----------DCVRAVWQNEGAGAFYRSYTTQLTMNVPFQ 239
++ K+R+Q+ + R DC + V Q EGA F++ + L
Sbjct: 237 LDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
Query: 240 AIHFMTYEFLQEHFNPQRR 258
F +YEF F+ R
Sbjct: 297 GFMFFSYEFFCNVFHCMNR 315
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 92.0 bits (227), Expect = 7e-19
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 40/315 (12%)
Query: 63 YEALPAGATVTTHMVA--GAVAGILEHCVMYPIDCVKTRMQ-----SLQPDPAARYRNVL 115
Y+ P G T VA G+V+G++ ++ P D +K R Q + DP+A+Y +L
Sbjct: 4 YDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGIL 63
Query: 116 EALWRIIRTEG---LWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG----- 167
+A +I++ EG W+ + + G G L F + L++++H G
Sbjct: 64 QASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSF-------EMLTELVHRGSVYDAR 116
Query: 168 --NSH-IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSP--YHRVTDCVRAVWQNEGAG 222
+ H + G A C+ATL ++P +V++ R P Y+ + V ++++EG
Sbjct: 117 EFSVHFVCGGLAACMATL----TVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQ 172
Query: 223 AFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFN-----PQRRYNPSSHVLSGACAGAVAAA 277
FY+ L P+ + F Y L+ + ++ ++L G+ AG ++
Sbjct: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
Query: 278 ATTPLDVCKTLLNT---QESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
T PLD+ K L + + A + + G+ + V Q G +F+G+ ++
Sbjct: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRY-KGLMDCAKQVLQKEGALGFFKGLSPSLLK 291
Query: 335 QIPSTAIAWSVYEFF 349
ST + YEFF
Sbjct: 292 AALSTGFMFFSYEFF 306
Score = 67.4 bits (163), Expect = 2e-11
Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 168 NSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYN---------SPYHRVTDCVRAVWQN 218
N+ AG V+ L+ A ++P +V+K R Q+ + + YH + R + Q
Sbjct: 13 NTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQE 72
Query: 219 EGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNP---SSHVLSGACAGAVA 275
EG AF++ + +++ + A+ F+++E L E + Y+ S H + G A +A
Sbjct: 73 EGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMA 132
Query: 276 AAATTPLDVCKTLLNTQ-ESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
P+DV +T Q E N+ + A T+Y+ G +++G+ +I
Sbjct: 133 TLTVHPVDVLRTRFAAQGEPKVYNT--------LRHAVGTMYRSEGPQVFYKGLAPTLIA 184
Query: 335 QIPSTAIAWSVYEFFKYL 352
P + +S Y K+L
Sbjct: 185 IFPYAGLQFSCYSSLKHL 202
Score = 65.9 bits (159), Expect = 6e-11
Identities = 51/199 (25%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 73 TTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMR 132
+ H V G +A + ++P+D ++TR + Q +P Y + A+ + R+EG +
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAA-QGEPKV-YNTLRHAVGTMYRSEGPQVFYK 176
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG--NSHIANGAAGCVATLLHDAAMNP 190
GL T P L F+CY LK I G N ++ N G A ++ P
Sbjct: 177 GLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYP 236
Query: 191 AEVVKQRMQMYNSPYHRVT-----------DCVRAVWQNEGAGAFYRSYTTQLTMNVPFQ 239
++ K+R+Q+ + R DC + V Q EGA F++ + L
Sbjct: 237 LDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
Query: 240 AIHFMTYEFLQEHFNPQRR 258
F +YEF F+ R
Sbjct: 297 GFMFFSYEFFCNVFHCMNR 315
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 92.0 bits (227), Expect = 7e-19
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 40/315 (12%)
Query: 63 YEALPAGATVTTHMVA--GAVAGILEHCVMYPIDCVKTRMQ-----SLQPDPAARYRNVL 115
Y+ P G T VA G+V+G++ ++ P D +K R Q + DP+A+Y +L
Sbjct: 4 YDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGIL 63
Query: 116 EALWRIIRTEG---LWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG----- 167
+A +I++ EG W+ + + G G L F + L++++H G
Sbjct: 64 QASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSF-------EMLTELVHRGSVYDAR 116
Query: 168 --NSH-IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSP--YHRVTDCVRAVWQNEGAG 222
+ H + G A C+ATL ++P +V++ R P Y+ + V ++++EG
Sbjct: 117 EFSVHFVCGGLAACMATL----TVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQ 172
Query: 223 AFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFN-----PQRRYNPSSHVLSGACAGAVAAA 277
FY+ L P+ + F Y L+ + ++ ++L G+ AG ++
Sbjct: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
Query: 278 ATTPLDVCKTLLNT---QESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
T PLD+ K L + + A + + G+ + V Q G +F+G+ ++
Sbjct: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRY-KGLMDCAKQVLQKEGALGFFKGLSPSLLK 291
Query: 335 QIPSTAIAWSVYEFF 349
ST + YEFF
Sbjct: 292 AALSTGFMFFSYEFF 306
Score = 67.4 bits (163), Expect = 2e-11
Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 168 NSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYN---------SPYHRVTDCVRAVWQN 218
N+ AG V+ L+ A ++P +V+K R Q+ + + YH + R + Q
Sbjct: 13 NTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQE 72
Query: 219 EGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNP---SSHVLSGACAGAVA 275
EG AF++ + +++ + A+ F+++E L E + Y+ S H + G A +A
Sbjct: 73 EGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMA 132
Query: 276 AAATTPLDVCKTLLNTQ-ESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
P+DV +T Q E N+ + A T+Y+ G +++G+ +I
Sbjct: 133 TLTVHPVDVLRTRFAAQGEPKVYNT--------LRHAVGTMYRSEGPQVFYKGLAPTLIA 184
Query: 335 QIPSTAIAWSVYEFFKYL 352
P + +S Y K+L
Sbjct: 185 IFPYAGLQFSCYSSLKHL 202
Score = 65.9 bits (159), Expect = 6e-11
Identities = 51/199 (25%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 73 TTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMR 132
+ H V G +A + ++P+D ++TR + Q +P Y + A+ + R+EG +
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAA-QGEPKV-YNTLRHAVGTMYRSEGPQVFYK 176
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG--NSHIANGAAGCVATLLHDAAMNP 190
GL T P L F+CY LK I G N ++ N G A ++ P
Sbjct: 177 GLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYP 236
Query: 191 AEVVKQRMQMYNSPYHRVT-----------DCVRAVWQNEGAGAFYRSYTTQLTMNVPFQ 239
++ K+R+Q+ + R DC + V Q EGA F++ + L
Sbjct: 237 LDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
Query: 240 AIHFMTYEFLQEHFNPQRR 258
F +YEF F+ R
Sbjct: 297 GFMFFSYEFFCNVFHCMNR 315
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 29/289 (10%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRN--VLEALWRIIRTEGLWRPMR 132
H+VAG AG + P+D +K MQ A+R N ++ ++IR G R
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRSNNMGIVGGFTQMIREGGARSLWR 264
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDV-----IHPGGNSHIANGAAGCVATLLHDAA 187
G + P A+ F YE++K+ + IH +A AG +A ++
Sbjct: 265 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIH---ERLVAGSLAGAIA----QSS 317
Query: 188 MNPAEVVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
+ P EV+K RM + + Y + DC R + EG AFY+ Y + +P+ I Y
Sbjct: 318 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 377
Query: 247 EFLQEHFNPQRRYN---PSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHI 301
E L+ + N P VL G + A+ PL + +T + Q S+ +
Sbjct: 378 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEV 437
Query: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
T M+S F+ + + G +RG+ + IP+ +I++ VYE K
Sbjct: 438 T-----MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 481
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 60 GPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALW 119
G D E L + +VAG++AG + +YP++ +KTRM + +Y +L+
Sbjct: 292 GSDQETL----RIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRK---TGQYSGMLDCAR 344
Query: 120 RIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSD--VIHPGGNSHIANGAAG 177
RI+ EG+ +G G P + A YE LK ++ A G
Sbjct: 345 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACG 404
Query: 178 CVATLLHDAAMNPAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLT 233
+++ A P +V+ RMQ S P ++ + + + EGA YR
Sbjct: 405 TMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFM 464
Query: 234 MNVPFQAIHFMTYEFLQEHFNPQRR 258
+P +I ++ YE L+ Q R
Sbjct: 465 KVIPAVSISYVVYENLKITLGVQSR 489
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
H+++G AGAV+ T PLD K L+ S + N I G T M + GG +
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMI-------REGGARS 261
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWR 361
+RG V+ P +AI + YE K L+ QE R
Sbjct: 262 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLR 299
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 29/289 (10%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRN--VLEALWRIIRTEGLWRPMR 132
H+VAG AG + P+D +K MQ A+R N ++ ++IR G R
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRSNNMGIVGGFTQMIREGGARSLWR 244
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDV-----IHPGGNSHIANGAAGCVATLLHDAA 187
G + P A+ F YE++K+ + IH +A AG +A ++
Sbjct: 245 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIH---ERLVAGSLAGAIA----QSS 297
Query: 188 MNPAEVVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
+ P EV+K RM + + Y + DC R + EG AFY+ Y + +P+ I Y
Sbjct: 298 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357
Query: 247 EFLQEHFNPQRRYN---PSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHI 301
E L+ + N P VL G + A+ PL + +T + Q S+ +
Sbjct: 358 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEV 417
Query: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
T M+S F+ + + G +RG+ + IP+ +I++ VYE K
Sbjct: 418 T-----MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 60 GPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALW 119
G D E L + +VAG++AG + +YP++ +KTRM + +Y +L+
Sbjct: 272 GSDQETL----RIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRK---TGQYSGMLDCAR 324
Query: 120 RIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSD--VIHPGGNSHIANGAAG 177
RI+ EG+ +G G P + A YE LK ++ A G
Sbjct: 325 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACG 384
Query: 178 CVATLLHDAAMNPAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLT 233
+++ A P +V+ RMQ S P ++ + + + EGA YR
Sbjct: 385 TMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFM 444
Query: 234 MNVPFQAIHFMTYEFLQEHFNPQRR 258
+P +I ++ YE L+ Q R
Sbjct: 445 KVIPAVSISYVVYENLKITLGVQSR 469
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
H+++G AGAV+ T PLD K L+ S + N I G T M + GG +
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMI-------REGGARS 241
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWR 361
+RG V+ P +AI + YE K L+ QE R
Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLR 279
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 29/289 (10%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRN--VLEALWRIIRTEGLWRPMR 132
H+VAG AG + P+D +K MQ A+R N ++ ++IR G R
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRSNNMGIVGGFTQMIREGGARSLWR 141
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDV-----IHPGGNSHIANGAAGCVATLLHDAA 187
G + P A+ F YE++K+ + IH +A AG +A ++
Sbjct: 142 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIH---ERLVAGSLAGAIA----QSS 194
Query: 188 MNPAEVVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
+ P EV+K RM + + Y + DC R + EG AFY+ Y + +P+ I Y
Sbjct: 195 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 254
Query: 247 EFLQEHFNPQRRYN---PSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHI 301
E L+ + N P VL G + A+ PL + +T + Q S+ +
Sbjct: 255 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEV 314
Query: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
T M+S F+ + + G +RG+ + IP+ +I++ VYE K
Sbjct: 315 T-----MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 358
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 60 GPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALW 119
G D E L + +VAG++AG + +YP++ +KTRM + +Y +L+
Sbjct: 169 GSDQETL----RIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRK---TGQYSGMLDCAR 221
Query: 120 RIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSD--VIHPGGNSHIANGAAG 177
RI+ EG+ +G G P + A YE LK ++ A G
Sbjct: 222 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACG 281
Query: 178 CVATLLHDAAMNPAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLT 233
+++ A P +V+ RMQ S P ++ + + + EGA YR
Sbjct: 282 TMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFM 341
Query: 234 MNVPFQAIHFMTYEFLQEHFNPQRR 258
+P +I ++ YE L+ Q R
Sbjct: 342 KVIPAVSISYVVYENLKITLGVQSR 366
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
H+++G AGAV+ T PLD K L+ S + N I G T M + GG +
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMI-------REGGARS 138
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWR 361
+RG V+ P +AI + YE K L+ QE R
Sbjct: 139 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLR 176
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 29/289 (10%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRN--VLEALWRIIRTEGLWRPMR 132
H+VAG AG + P+D +K MQ A+R N ++ ++IR G R
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRSNNMGIVGGFTQMIREGGARSLWR 278
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDV-----IHPGGNSHIANGAAGCVATLLHDAA 187
G + P A+ F YE++K+ + IH +A AG +A ++
Sbjct: 279 GNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIH---ERLVAGSLAGAIA----QSS 331
Query: 188 MNPAEVVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
+ P EV+K RM + + Y + DC R + EG AFY+ Y + +P+ I Y
Sbjct: 332 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 391
Query: 247 EFLQEHFNPQRRYN---PSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHI 301
E L+ + N P VL G + A+ PL + +T + Q S+ +
Sbjct: 392 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEV 451
Query: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
T M+S F+ + + G +RG+ + IP+ +I++ VYE K
Sbjct: 452 T-----MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 60 GPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALW 119
G D E L + +VAG++AG + +YP++ +KTRM + +Y +L+
Sbjct: 306 GSDQETL----RIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRK---TGQYSGMLDCAR 358
Query: 120 RIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSD--VIHPGGNSHIANGAAG 177
RI+ EG+ +G G P + A YE LK ++ A G
Sbjct: 359 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACG 418
Query: 178 CVATLLHDAAMNPAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLT 233
+++ A P +V+ RMQ S P ++ + + + EGA YR
Sbjct: 419 TMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFM 478
Query: 234 MNVPFQAIHFMTYEFLQEHFNPQRR 258
+P +I ++ YE L+ Q R
Sbjct: 479 KVIPAVSISYVVYENLKITLGVQSR 503
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
H+++G AGAV+ T PLD K L+ S + N I G T M + GG +
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMI-------REGGARS 275
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWR 361
+RG V+ P +AI + YE K L+ QE R
Sbjct: 276 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLR 313
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 90.5 bits (223), Expect = 2e-18
Identities = 75/279 (26%), Positives = 120/279 (43%), Gaps = 16/279 (5%)
Query: 79 GAVAGILEHCVMYPIDCVKTRMQSLQPDPAA----RYRNVLEALWRIIRTEGLWRPMRGL 134
G+VAG + +YPID VKTRMQ+ + + Y+N + +++R EG + RGL
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 135 NVTATGAGPAHALYFAC--YEKLKKTLSDVIHPGGNSHIANGAAGCVATLLHDAAMNPAE 192
G P A+ + + K T D P +A G AG + NP E
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIF----TNPLE 448
Query: 193 VVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEH 252
+VK R+Q+ V ++ G Y+ ++PF AI+F Y +
Sbjct: 449 IVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLL 508
Query: 253 FNPQRRYNPSSHVL-SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASA 311
+ + ++L +GA AG AA+ TP DV KT L ++ +G+
Sbjct: 509 LADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTY-----SGVIDC 563
Query: 312 FRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
FR + + G +A+++G ARV P + YE +
Sbjct: 564 FRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQ 602
Score = 64.7 bits (156), Expect = 1e-10
Identities = 56/187 (29%), Positives = 85/187 (45%), Gaps = 20/187 (10%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQ---SLQPDPAARYRNVLEALWRIIRTEGLWRPMR 132
++AG AG + P++ VK R+Q + P NVL L G++ +
Sbjct: 430 VLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDL-------GIFGLYK 482
Query: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDVI-HPGGNSHIANGA-AGCVATLLHDAAMNP 190
G P A+YF Y K L+D H GG + +A GA AG A L + P
Sbjct: 483 GAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASL----VTP 538
Query: 191 AEVVKQRMQMY----NSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
A+V+K R+Q+ + Y V DC R + + EG AF++ ++ + P + +TY
Sbjct: 539 ADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTY 598
Query: 247 EFLQEHF 253
E LQ F
Sbjct: 599 ELLQRWF 605
Score = 62.4 bits (150), Expect = 6e-10
Identities = 53/187 (28%), Positives = 80/187 (42%), Gaps = 20/187 (10%)
Query: 177 GCVATLLHDAAMNPAEVVKQRMQMYNSP--------YHRVTDCVRAVWQNEGAGAFYRSY 228
G VA + A+ P ++VK RMQ Y DC + V + EG YR
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 229 TTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNP-SSHVLSGACAGAVAAAATTPLDVCKT 287
QL P +AI +F+++ F + P + VL+G CAG T PL++ K
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKI 452
Query: 288 LLNTQESLALNSHITGHIT-GMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVY 346
L + G IT G + V + G+ ++G +A + IP +AI + VY
Sbjct: 453 RLQ----------VAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVY 502
Query: 347 EFFKYLI 353
K L+
Sbjct: 503 AHCKLLL 509
Score = 40.0 bits (92), Expect = 0.003
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 5/91 (5%)
Query: 268 GACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMAS--AFRTVYQVGGVTAYF 325
G+ AGAV A A P+D+ KT + Q + + G + S F+ V + G +
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRG---SGSVVGELMYKNSFDCFKKVLRYEGFFGLY 389
Query: 326 RGVQARVIYQIPSTAIAWSVYEFFKYLITKR 356
RG+ ++I P AI +V +F + T+R
Sbjct: 390 RGLIPQLIGVAPEKAIKLTVNDFVRDKFTRR 420
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 89.4 bits (220), Expect = 5e-18
Identities = 72/291 (24%), Positives = 125/291 (42%), Gaps = 19/291 (6%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
++AG +AG + P+D +K MQ + N+ ++++ G+ RG
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQV--HGSKSDKMNIFGGFRQMVKEGGIRSLWRGNG 255
Query: 136 VTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSH--IANGAAGCVATLLHDAAMNPAEV 193
P A+ F YE+ KK L++ G I+ AG A + P EV
Sbjct: 256 TNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTF----IYPMEV 311
Query: 194 VKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEH 252
+K R+ + + Y + DC + + ++EG GAFY+ Y L +P+ I YE L+ +
Sbjct: 312 MKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSY 371
Query: 253 F---NPQRRYNPSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITG 307
+ + NP VL GA + A+ PL + +T + Q L + +
Sbjct: 372 WLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----N 426
Query: 308 MASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQE 358
M FR + G+ +RG+ + +P+ I++ VYE K + Q+
Sbjct: 427 MVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 477
Score = 50.4 bits (119), Expect = 2e-06
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 265 VLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAY 324
+L+G AGAV+ +T PLD K ++ S + +I G FR + + GG+ +
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFG-------GFRQMVKEGGIRSL 250
Query: 325 FRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEE 359
+RG VI P TA+ + YE +K L+T+ ++
Sbjct: 251 WRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQK 285
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 89.4 bits (220), Expect = 5e-18
Identities = 72/291 (24%), Positives = 125/291 (42%), Gaps = 19/291 (6%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
++AG +AG + P+D +K MQ + N+ ++++ G+ RG
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQV--HGSKSDKMNIFGGFRQMVKEGGIRSLWRGNG 236
Query: 136 VTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSH--IANGAAGCVATLLHDAAMNPAEV 193
P A+ F YE+ KK L++ G I+ AG A + P EV
Sbjct: 237 TNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTF----IYPMEV 292
Query: 194 VKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEH 252
+K R+ + + Y + DC + + ++EG GAFY+ Y L +P+ I YE L+ +
Sbjct: 293 MKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSY 352
Query: 253 F---NPQRRYNPSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITG 307
+ + NP VL GA + A+ PL + +T + Q L + +
Sbjct: 353 WLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----N 407
Query: 308 MASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQE 358
M FR + G+ +RG+ + +P+ I++ VYE K + Q+
Sbjct: 408 MVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
Score = 50.4 bits (119), Expect = 2e-06
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 265 VLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAY 324
+L+G AGAV+ +T PLD K ++ S + +I G FR + + GG+ +
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFG-------GFRQMVKEGGIRSL 231
Query: 325 FRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEE 359
+RG VI P TA+ + YE +K L+T+ ++
Sbjct: 232 WRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQK 266
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 88.6 bits (218), Expect = 8e-18
Identities = 72/290 (24%), Positives = 121/290 (41%), Gaps = 32/290 (11%)
Query: 77 VAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLNV 136
VAG ++G L + +P D VK R+Q+ YR +++ + +I R E L +G++
Sbjct: 7 VAGWISGALGLVLGHPFDTVKVRLQT-----QTTYRGIVDCMVKIYRHESLLGFFKGMSF 61
Query: 137 TATGAGPAHALYFACYEKLKKTLSDVIH------PGGNSHIANGAAGCVATLLHDAAMNP 190
+++ F Y L+ H P HI AGC L + P
Sbjct: 62 PIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIF--LAGCTGGFLQAYCLAP 119
Query: 191 AEVVKQRMQMYNSP----------YHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA 240
+++K R+Q P Y C ++++ EG +R + P
Sbjct: 120 FDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVG 179
Query: 241 IHFMTYEFLQEHFNPQRRYNPSSH--VLSGACAGAVAAAATTPLDVCKTLLNTQESLALN 298
I+F+TYE L + P+ + NPSS +++G AG + A TPLD+ K+ + L
Sbjct: 180 IYFITYEGLCRQYTPEGQ-NPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMD---GLR 235
Query: 299 SHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEF 348
+ GM + + G+ +FRGV P A+ + YE+
Sbjct: 236 RRV---YQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
Score = 68.6 bits (166), Expect = 9e-12
Identities = 54/183 (29%), Positives = 78/183 (42%), Gaps = 13/183 (7%)
Query: 77 VAGAVAGILEHCVMYPIDCVKTRMQS-----LQP-DPAARYRNVLEALWRIIRTEGLWRP 130
+AG G L+ + P D +K R+Q+ QP P RY+ + I R EG
Sbjct: 104 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 163
Query: 131 MRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANG-AAGCVATLLHDAAMN 189
RG P +YF YE L + + G N A AG A + A
Sbjct: 164 FRGAWALTLRDTPTVGIYFITYEGLCRQYTP---EGQNPSSATVLVAGGFAGIASWVAAT 220
Query: 190 PAEVVKQRMQM---YNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
P +++K RMQM Y + DC+ + + EG G F+R T P A+ F++Y
Sbjct: 221 PLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 280
Query: 247 EFL 249
E+L
Sbjct: 281 EYL 283
Score = 48.9 bits (115), Expect = 7e-06
Identities = 34/91 (37%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 67 PAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAAR--YRNVLEALWRIIRT 124
P+ ATV +VAG AGI P+D +K+RMQ D R Y+ +L+ + IR
Sbjct: 199 PSSATV---LVAGGFAGIASWVAATPLDMIKSRMQM---DGLRRRVYQGMLDCMVSSIRQ 252
Query: 125 EGLWRPMRGLNVTATGAGPAHALYFACYEKL 155
EGL RG+ + + A P +A+ F YE L
Sbjct: 253 EGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 88.2 bits (217), Expect = 1e-17
Identities = 75/284 (26%), Positives = 124/284 (43%), Gaps = 21/284 (7%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
+VAGAVAG + P+D +K MQ + R N+L L ++ G+ RG
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQ-VHASKTNRL-NILGGLRSMVLEGGIRSLWRGNG 246
Query: 136 VTATGAGPAHALYFACYEKLKKTL---SDVIHPGGNSHIANGAAGCVATLLHDAAMNPAE 192
+ P A+ F YE++K+ + + +H +A AG A + + P E
Sbjct: 247 INVLKIAPESAIKFMAYEQIKRAILGQQETLHVQ-ERFVAGSLAGATAQTI----IYPME 301
Query: 193 VVKQRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQE 251
V+K R+ + + Y + DC R + + EG AFYR Y + +P+ I YE L+
Sbjct: 302 VLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKN 361
Query: 252 HFNPQRRY---NPSSHVL--SGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHIT 306
+ Q + +P VL G + A+ PL + +T + Q S+ G
Sbjct: 362 WWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIE-----GGPQL 416
Query: 307 GMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
M R + G+ +RG+ + IP+ +I++ VYE K
Sbjct: 417 SMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMK 460
Score = 58.5 bits (140), Expect = 9e-09
Identities = 48/186 (25%), Positives = 79/186 (42%), Gaps = 9/186 (4%)
Query: 72 VTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPM 131
V VAG++AG ++YP++ +KTR+ + +Y+ +L+ RI+ EG
Sbjct: 279 VQERFVAGSLAGATAQTIIYPMEVLKTRLTLRR---TGQYKGLLDCARRILEREGPRAFY 335
Query: 132 RGLNVTATGAGPAHALYFACYEKLKK-TLSDVIHPGGNSHI-ANGAAGCVATLLHDAAMN 189
RG G P + A YE LK L H + I A G +++ A
Sbjct: 336 RGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASY 395
Query: 190 PAEVVKQRMQMYNS----PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMT 245
P +V+ RMQ S P + +R + EG YR +P +I ++
Sbjct: 396 PLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVV 455
Query: 246 YEFLQE 251
YE +++
Sbjct: 456 YENMKQ 461
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 7/94 (7%)
Query: 265 VLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAY 324
+++GA AGAV+ T PLD K + S +I G + R++ GG+ +
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGL-------RSMVLEGGIRSL 241
Query: 325 FRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQE 358
+RG V+ P +AI + YE K I +QE
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAILGQQE 275
Score = 35.4 bits (80), Expect = 0.081
Identities = 21/84 (25%), Positives = 37/84 (44%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
+ G ++ YP+ V+TRMQ+ ++L L I+ EG+ RG+
Sbjct: 380 LACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIA 439
Query: 136 VTATGAGPAHALYFACYEKLKKTL 159
PA ++ + YE +K+ L
Sbjct: 440 PNFMKVIPAVSISYVVYENMKQAL 463
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 86.3 bits (212), Expect = 4e-17
Identities = 79/305 (25%), Positives = 128/305 (41%), Gaps = 38/305 (12%)
Query: 71 TVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRP 130
++T ++ G VAG++ ++PID KTR+Q+ A Y+ +++ L + R EG +
Sbjct: 7 SITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGK--AMYKGMIDCLMKTARAEGFFGM 64
Query: 131 MRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIA-NGAAGCVATLLHDAAMN 189
RG V T P A+ A + ++ L + G ++ AGC A +
Sbjct: 65 YRGAAVNLTLVTPEKAIKLAANDFFRRLLME---DGMQRNLKMEMLAGCGAGMCQVVVTC 121
Query: 190 PAEVVKQRMQ-----------------------MYNSPYHRVTDCVRAVWQ---NEGAGA 223
P E++K ++Q ++ HR W+ +G
Sbjct: 122 PMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAG 181
Query: 224 FYRSYTTQLTMNVPFQAIHFMTYEFLQE-HFNPQRRYNPSSH-VLSGACAGAVAAAATTP 281
YR L ++PF I+F + L FN +H +SG AG++AA A TP
Sbjct: 182 LYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAAVAVTP 241
Query: 282 LDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAI 341
LDV KT + T + L + IT A R ++ G +A+ +G R + P I
Sbjct: 242 LDVLKTRIQTLKK-GLGEDMYSGITDCA---RKLWIQEGPSAFMKGAGCRALVIAPLFGI 297
Query: 342 AWSVY 346
A VY
Sbjct: 298 AQGVY 302
Score = 60.1 bits (144), Expect = 3e-09
Identities = 51/200 (25%), Positives = 84/200 (42%), Gaps = 32/200 (16%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQ--------------------SLQPDPAARYRNVL 115
M+AG AG+ + V P++ +K ++Q S A+ +R
Sbjct: 106 MLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPS 165
Query: 116 EAL--WRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIAN 173
L W ++RT+GL RGL T P +YF + L + + G S +
Sbjct: 166 ATLIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNEL-AGKASFAHS 224
Query: 174 GAAGCVATLLHDAAMNPAEVVKQRMQ-----MYNSPYHRVTDCVRAVWQNEGAGAFYRSY 228
+GCVA + A+ P +V+K R+Q + Y +TDC R +W EG AF +
Sbjct: 225 FVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGA 284
Query: 229 TTQLTMNVPF----QAIHFM 244
+ + P Q ++F+
Sbjct: 285 GCRALVIAPLFGIAQGVYFI 304
Score = 37.0 bits (84), Expect = 0.028
Identities = 22/92 (23%), Positives = 37/92 (40%), Gaps = 7/92 (7%)
Query: 262 SSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGV 321
++ +++G AG V P+D+ KT L Q A+ GM + G
Sbjct: 9 TAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYK-------GMIDCLMKTARAEGF 61
Query: 322 TAYFRGVQARVIYQIPSTAIAWSVYEFFKYLI 353
+RG + P AI + +FF+ L+
Sbjct: 62 FGMYRGAAVNLTLVTPEKAIKLAANDFFRRLL 93
Score = 31.2 bits (69), Expect = 1.5
Identities = 24/92 (26%), Positives = 40/92 (43%), Gaps = 5/92 (5%)
Query: 63 YEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAA-RYRNVLEALWRI 121
+ L A+ V+G VAG + + P+D +KTR+Q+L+ Y + + ++
Sbjct: 212 FNELAGKASFAHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKL 271
Query: 122 IRTEGLWRPMRGLNVTATGAGP----AHALYF 149
EG M+G A P A +YF
Sbjct: 272 WIQEGPSAFMKGAGCRALVIAPLFGIAQGVYF 303
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 85.5 bits (210), Expect = 7e-17
Identities = 68/284 (23%), Positives = 118/284 (41%), Gaps = 23/284 (8%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
+++GA+AG + P+D K MQ + N+L L +++ G RG
Sbjct: 96 LLSGAMAGAVSRTGTAPLDRAKVYMQVYSSK--TNFTNLLGGLQSMVQEGGFRSLWRGNG 153
Query: 136 VTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVK 195
+ P +A+ F+ +E+ K + G AG +A + +NP EV+K
Sbjct: 154 INVLKIAPEYAIKFSVFEQCKNYFCGI--QGSPPFQERLLAGSLAVAISQTLINPMEVLK 211
Query: 196 QRMQMYNS-PYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQ---- 250
R+ + + Y + DC R + Q EG A YR Y + +P+ YE LQ
Sbjct: 212 TRLTLRRTGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYEMLQCFWV 271
Query: 251 ----EHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHIT 306
+ +P + SS LS C A+ PL + +T + Q++ + G
Sbjct: 272 KSGRDMGDPSGLVSLSSVTLSTTC----GQMASYPLTLVRTRMQAQDT------VEGSNP 321
Query: 307 GMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFK 350
M + + G +RG+ ++ +P+ I++ VYE K
Sbjct: 322 TMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMK 365
Score = 37.4 bits (85), Expect = 0.021
Identities = 32/107 (29%), Positives = 47/107 (43%), Gaps = 9/107 (8%)
Query: 53 VRQDPDSGPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYR 112
V+ D G D L + ++VT G +A YP+ V+TRMQ+ Q
Sbjct: 271 VKSGRDMG-DPSGLVSLSSVTLSTTCGQMAS-------YPLTLVRTRMQA-QDTVEGSNP 321
Query: 113 NVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTL 159
+ L RI+ +G RG+ T PA + + YE +KKTL
Sbjct: 322 TMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKTL 368
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 83.6 bits (205), Expect = 3e-16
Identities = 73/304 (24%), Positives = 127/304 (41%), Gaps = 34/304 (11%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRM---QSLQPDPAARYRNVLEALWRIIRTEGLWRPM 131
+++AG G+L + ++P+D VK R L+ P +Y +L L I + +GL
Sbjct: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP--KYNGILHCLTTIWKLDGLRGLY 82
Query: 132 RGLNVTATGAGPAHALYFACYEKLK--KTLSDVIHPGGNSHIANGAAGCVATLLHDAAMN 189
+G+ GAG + LYF Y +K KT ++ + A TL N
Sbjct: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTL---CITN 139
Query: 190 PAEVVKQRMQM-----YNSP---YHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAI 241
P V K R+ + NSP Y + D + +++ EG Y+ + L A+
Sbjct: 140 PLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGL-FGTSHGAL 198
Query: 242 HFMTYEFLQEHFN------PQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESL 295
FM YE L+ +N P+ + + ++ A + A AAT P V + L Q
Sbjct: 199 QFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMF 258
Query: 296 ALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITK 355
+G+ ++ GV +++G+ +I P+ I + VYE + +
Sbjct: 259 ---------YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLLD 309
Query: 356 RQEE 359
+E+
Sbjct: 310 LREK 313
Score = 67.0 bits (162), Expect = 3e-11
Identities = 54/183 (29%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 73 TTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPD-----PAARYRNVLEALWRIIRTEGL 127
T ++V+ A AG + C+ P+ KTR+ LQ D P +Y+ + + L +I + EG+
Sbjct: 121 TEYLVSAAEAGAMTLCITNPLWVTKTRLM-LQYDAVVNSPHRQYKGMFDTLVKIYKYEGV 179
Query: 128 WRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVATL---LH 184
+G G AL F YE LK + I+ + ++ VA L
Sbjct: 180 RGLYKGFVPGLFGTSHG-ALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFA 238
Query: 185 DAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFM 244
AA P +VV+ R+Q + Y V D + W+ EG G FY+ L P I F+
Sbjct: 239 VAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFV 298
Query: 245 TYE 247
YE
Sbjct: 299 VYE 301
Score = 35.4 bits (80), Expect = 0.081
Identities = 22/99 (22%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Query: 264 HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTA 323
++++G G ++ A PLD+ K + L L G + T++++ G+
Sbjct: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNG----ILHCLTTIWKLDGLRG 80
Query: 324 YFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWRA 362
++GV + ++W +Y FF I + E RA
Sbjct: 81 LYQGVTPNIW----GAGLSWGLYFFFYNAIKSYKTEGRA 115
>gi|115430257 solute carrier family 25, member 26 [Homo sapiens]
Length = 274
Score = 83.6 bits (205), Expect = 3e-16
Identities = 78/263 (29%), Positives = 118/263 (44%), Gaps = 33/263 (12%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
+VAG VAG+ +++P+D +KTR+QS Q + G G+
Sbjct: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ---------------GFNKAGGFHGIYAGVP 54
Query: 136 VTATGAGPAHALYFACYEKLKKTL----SDVIHPGGNSHIANGAAGCVATLLHDAAMNPA 191
A G+ P A +F YE +K L S + P H+ +AG V L P+
Sbjct: 55 SAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTP--MKHMLAASAGEVVACL---IRVPS 109
Query: 192 EVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQE 251
EVVKQR Q+ S R + EG YR Y + + +PF + F +E L+
Sbjct: 110 EVVKQRAQV--SASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKA 167
Query: 252 HFNPQRRYNPSS--HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMA 309
++ ++ + S + GA AG AAA TTPLDV KT + + A +S G++
Sbjct: 168 LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAK--AGSSTADGNV---L 222
Query: 310 SAFRTVYQVGGVTAYFRGVQARV 332
S V++ G+ F GV R+
Sbjct: 223 SVLHGVWRSQGLAGLFAGVFPRM 245
Score = 45.8 bits (107), Expect = 6e-05
Identities = 43/190 (22%), Positives = 76/190 (40%), Gaps = 24/190 (12%)
Query: 171 IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTT 230
+A AG VA + D + P + +K R+Q SP + + G Y +
Sbjct: 7 VAALVAGGVAGVSVDLILFPLDTIKTRLQ---SP--------QGFNKAGGFHGIYAGVPS 55
Query: 231 QLTMNVPFQAIHFMTYEFLQE--HFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTL 288
+ P A F+TYE+++ H + P H+L+ + VA P +V K
Sbjct: 56 AAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQR 115
Query: 289 LNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEF 348
S T F + G+ +RG ++ V+ +IP + + + ++E
Sbjct: 116 AQVSAS-----------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWES 164
Query: 349 FKYLITKRQE 358
K L + RQ+
Sbjct: 165 LKALWSWRQD 174
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 82.4 bits (202), Expect = 6e-16
Identities = 73/285 (25%), Positives = 122/285 (42%), Gaps = 21/285 (7%)
Query: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAAR---YRNVLEALWRIIRTEGLWRPM 131
+++AG G+ V +P+D VK R+Q+ P + Y + + + EG+
Sbjct: 13 NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
Query: 132 RGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGN-SHIANGAAGCVATLLHDAAMNP 190
RG+ G P A+ F + KK HP S+ AAG ++ + M P
Sbjct: 73 RGMAAPIIGVTPMFAVCFFGFGLGKKLQQK--HPEDVLSYPQLFAAGMLSGVFTTGIMTP 130
Query: 191 AEVVKQRMQMY----NSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
E +K +Q+ S Y DC + ++Q G Y+ L +VP ++FMTY
Sbjct: 131 GERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTY 190
Query: 247 EFLQEHFNPQ-RRYNPSSH---VLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHIT 302
E+L+ F P+ +R + S +++G AG A P DV K+ T
Sbjct: 191 EWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPP-------G 243
Query: 303 GHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYE 347
+ G R + + GVT+ ++G A +I P+ A + +E
Sbjct: 244 KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
Score = 46.2 bits (108), Expect = 5e-05
Identities = 40/177 (22%), Positives = 70/177 (39%), Gaps = 18/177 (10%)
Query: 189 NPAEVVKQRMQ-----MYNSP--YHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAI 241
+P + VK R+Q + P Y DC R EG YR + P A+
Sbjct: 29 HPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAV 88
Query: 242 HFMTY----EFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLAL 297
F + + Q+H P+ + +G +G TP + K LL Q S
Sbjct: 89 CFFGFGLGKKLQQKH--PEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGE 146
Query: 298 NSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLIT 354
+ + TG + +YQ G+ ++G ++ +P++ + + YE+ K + T
Sbjct: 147 SKY-----TGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFT 198
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAAR-YRNVLEALWRIIRTEGLWRPMRGL 134
+VAG +AGI V P D +K+R Q+ P +R+VL L IR EG+ +G
Sbjct: 213 LVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLREL---IRDEGVTSLYKGF 269
Query: 135 NVTATGAGPAHALYFACYEKLKKTLS 160
N A PA+A F +E K L+
Sbjct: 270 NAVMIRAFPANAACFLGFEVAMKFLN 295
Score = 33.5 bits (75), Expect = 0.31
Identities = 26/100 (26%), Positives = 39/100 (39%), Gaps = 2/100 (2%)
Query: 260 NPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVG 319
+P ++L+G G PLD K L TQ +G FR
Sbjct: 9 SPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQ--PPMYSGTFDCFRKTLFRE 66
Query: 320 GVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEE 359
G+T +RG+ A +I P A+ + + K L K E+
Sbjct: 67 GITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPED 106
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,590,007
Number of Sequences: 37866
Number of extensions: 767720
Number of successful extensions: 4831
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 3809
Number of HSP's gapped (non-prelim): 676
length of query: 364
length of database: 18,247,518
effective HSP length: 104
effective length of query: 260
effective length of database: 14,309,454
effective search space: 3720458040
effective search space used: 3720458040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.