Search of human proteins with 109633046

Search of human proteins with 109633046

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 2 [Homo sapiens]
         (395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ...   809   0.0  
gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ...   800   0.0  
gi|28373086 sialyltransferase 6 isoform i [Homo sapiens]              231   9e-61
gi|28373078 sialyltransferase 6 isoform f [Homo sapiens]              231   9e-61
gi|28373068 sialyltransferase 6 isoform a [Homo sapiens]              231   9e-61
gi|28373082 sialyltransferase 6 isoform g [Homo sapiens]              231   1e-60
gi|28373070 sialyltransferase 6 isoform b [Homo sapiens]              230   1e-60
gi|5454060 sialyltransferase 6 isoform j [Homo sapiens]               230   1e-60
gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens]               168   9e-42
gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [H...   163   3e-40
gi|28373074 sialyltransferase 6 isoform d [Homo sapiens]              124   1e-28
gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [H...    92   6e-19
gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [...    90   4e-18
gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [H...    90   4e-18
gi|21264332 sialyltransferase 7A [Homo sapiens]                        80   4e-15
gi|110815855 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltran...    75   1e-13
gi|5174677 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf...    73   5e-13
gi|192448440 sialyltransferase 7B [Homo sapiens]                       69   6e-12
gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2...    67   4e-11
gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 ...    67   4e-11
gi|5031999 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf...    66   6e-11
gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 i...    66   6e-11
gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ...    66   6e-11
gi|13569938 sialyltransferase 7E [Homo sapiens]                        58   1e-08
gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2...    57   4e-08
gi|21361444 sialytransferase 7F [Homo sapiens]                         52   7e-07
gi|28373092 sialyltransferase 7D isoform a [Homo sapiens]              50   5e-06
gi|28373101 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans...    49   6e-06
gi|229892273 sialyltransferase 7C isoform 1 [Homo sapiens]             46   5e-05
gi|229892275 sialyltransferase 7C isoform 2 [Homo sapiens]             46   5e-05

>gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
           isoform 2 [Homo sapiens]
          Length = 395

 Score =  809 bits (2090), Expect = 0.0
 Identities = 395/395 (100%), Positives = 395/395 (100%)

Query: 1   MASVPMPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRPSLLLKDILKCTLLVFGVWILYIL 60
           MASVPMPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRPSLLLKDILKCTLLVFGVWILYIL
Sbjct: 1   MASVPMPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRPSLLLKDILKCTLLVFGVWILYIL 60

Query: 61  KLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLP 120
           KLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLP
Sbjct: 61  KLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLP 120

Query: 121 FVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGI 180
           FVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGI
Sbjct: 121 FVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGI 180

Query: 181 LHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVA 240
           LHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVA
Sbjct: 181 LHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVA 240

Query: 241 VLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQ 300
           VLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQ
Sbjct: 241 VLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQ 300

Query: 301 YSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAM 360
           YSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAM
Sbjct: 301 YSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAM 360

Query: 361 NFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDREF 395
           NFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDREF
Sbjct: 361 NFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDREF 395


>gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
           isoform 1 [Homo sapiens]
          Length = 418

 Score =  800 bits (2066), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 6   MPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRPSLLLKDILKCTLLVFGVWILYILKLNYT 65
           MPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRPSLLLKDILKCTLLVFGVWILYILKLNYT
Sbjct: 29  MPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRPSLLLKDILKCTLLVFGVWILYILKLNYT 88

Query: 66  TEECDMKKMHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKA 125
           TEECDMKKMHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKA
Sbjct: 89  TEECDMKKMHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKA 148

Query: 126 PKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLE 185
           PKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLE
Sbjct: 149 PKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLE 208

Query: 186 LGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKS 245
           LGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKS
Sbjct: 209 LGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKS 268

Query: 246 VDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQ 305
           VDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQ
Sbjct: 269 VDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQ 328

Query: 306 SRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTM 365
           SRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTM
Sbjct: 329 SRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTM 388

Query: 366 HNVTTETKFLLKLVKEGVVKDLSGGIDREF 395
           HNVTTETKFLLKLVKEGVVKDLSGGIDREF
Sbjct: 389 HNVTTETKFLLKLVKEGVVKDLSGGIDREF 418


>gi|28373086 sialyltransferase 6 isoform i [Homo sapiens]
          Length = 413

 Score =  231 bits (589), Expect = 9e-61
 Identities = 125/313 (39%), Positives = 187/313 (59%), Gaps = 6/313 (1%)

Query: 79  PDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPP 138
           P   + A KYA    +  C+P +A   M  +F  R+S     F+  + +      ++ PP
Sbjct: 107 PRPAELATKYAN-FSEGACKPGYASALMTAIFP-RFSKPAPMFLDDSFRKWARIREFVPP 164

Query: 139 FGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIR 198
           FG +   + ++ +L +  E+ L   L +  CRRC+++G+GG+L    LG  ++ +D+V+R
Sbjct: 165 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR 224

Query: 199 LNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKE 258
           LNSAPV+G+ + VG+KTT+R+TYPEGA     +Y  + LFV   FK  DF WL+ +V KE
Sbjct: 225 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE 284

Query: 259 TLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTI 318
            +       FWK VA ++P +P   RILNP  I+E AF ++      +   GR  N+PT+
Sbjct: 285 RVS--ASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPF-NNGLMGRG-NIPTL 340

Query: 319 GVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
           G +AV +A H CDEV++AGFGYD++ P  PLHY+++  MAA+     HN+  E +FL KL
Sbjct: 341 GSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 400

Query: 379 VKEGVVKDLSGGI 391
           VK  V+ DLS GI
Sbjct: 401 VKARVITDLSSGI 413


>gi|28373078 sialyltransferase 6 isoform f [Homo sapiens]
          Length = 429

 Score =  231 bits (589), Expect = 9e-61
 Identities = 125/313 (39%), Positives = 187/313 (59%), Gaps = 6/313 (1%)

Query: 79  PDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPP 138
           P   + A KYA    +  C+P +A   M  +F  R+S     F+  + +      ++ PP
Sbjct: 123 PRPAELATKYAN-FSEGACKPGYASALMTAIFP-RFSKPAPMFLDDSFRKWARIREFVPP 180

Query: 139 FGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIR 198
           FG +   + ++ +L +  E+ L   L +  CRRC+++G+GG+L    LG  ++ +D+V+R
Sbjct: 181 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR 240

Query: 199 LNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKE 258
           LNSAPV+G+ + VG+KTT+R+TYPEGA     +Y  + LFV   FK  DF WL+ +V KE
Sbjct: 241 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE 300

Query: 259 TLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTI 318
            +       FWK VA ++P +P   RILNP  I+E AF ++      +   GR  N+PT+
Sbjct: 301 RVS--ASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPF-NNGLMGRG-NIPTL 356

Query: 319 GVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
           G +AV +A H CDEV++AGFGYD++ P  PLHY+++  MAA+     HN+  E +FL KL
Sbjct: 357 GSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 416

Query: 379 VKEGVVKDLSGGI 391
           VK  V+ DLS GI
Sbjct: 417 VKARVITDLSSGI 429


>gi|28373068 sialyltransferase 6 isoform a [Homo sapiens]
          Length = 444

 Score =  231 bits (589), Expect = 9e-61
 Identities = 125/313 (39%), Positives = 187/313 (59%), Gaps = 6/313 (1%)

Query: 79  PDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPP 138
           P   + A KYA    +  C+P +A   M  +F  R+S     F+  + +      ++ PP
Sbjct: 138 PRPAELATKYAN-FSEGACKPGYASALMTAIFP-RFSKPAPMFLDDSFRKWARIREFVPP 195

Query: 139 FGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIR 198
           FG +   + ++ +L +  E+ L   L +  CRRC+++G+GG+L    LG  ++ +D+V+R
Sbjct: 196 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR 255

Query: 199 LNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKE 258
           LNSAPV+G+ + VG+KTT+R+TYPEGA     +Y  + LFV   FK  DF WL+ +V KE
Sbjct: 256 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE 315

Query: 259 TLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTI 318
            +       FWK VA ++P +P   RILNP  I+E AF ++      +   GR  N+PT+
Sbjct: 316 RVS--ASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPF-NNGLMGRG-NIPTL 371

Query: 319 GVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
           G +AV +A H CDEV++AGFGYD++ P  PLHY+++  MAA+     HN+  E +FL KL
Sbjct: 372 GSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 431

Query: 379 VKEGVVKDLSGGI 391
           VK  V+ DLS GI
Sbjct: 432 VKARVITDLSSGI 444


>gi|28373082 sialyltransferase 6 isoform g [Homo sapiens]
          Length = 359

 Score =  231 bits (588), Expect = 1e-60
 Identities = 129/343 (37%), Positives = 200/343 (58%), Gaps = 7/343 (2%)

Query: 50  LVFGVWILYILKLNYTTEECDMKKMHYVDPD-HVKRAQKYAQQVLQKECRPKFAKTSMAL 108
           L +  W L++L+    ++   +  +  +D     + A KYA    +  C+P +A   M  
Sbjct: 23  LYYSAWKLHLLQWEEDSKYDRLGFLLNLDSKLPAELATKYAN-FSEGACKPGYASALMTA 81

Query: 109 LFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKT 168
           +F  R+S     F+  + +      ++ PPFG +   + ++ +L +  E+ L   L +  
Sbjct: 82  IFP-RFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLR 140

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS 228
           CRRC+++G+GG+L    LG  ++ +D+V+RLNSAPV+G+ + VG+KTT+R+TYPEGA   
Sbjct: 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQR 200

Query: 229 DLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNP 288
             +Y  + LFV   FK  DF WL+ +V KE +       FWK VA ++P +P   RILNP
Sbjct: 201 PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVS--ASDGFWKSVATRVPKEPPEIRILNP 258

Query: 289 VIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTP 348
             I+E AF ++      +   GR  N+PT+G +AV +A H CDEV++AGFGYD++ P  P
Sbjct: 259 YFIQEAAFTLIGLPF-NNGLMGRG-NIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAP 316

Query: 349 LHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDLSGGI 391
           LHY+++  MAA+     HN+  E +FL KLVK  V+ DLS GI
Sbjct: 317 LHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI 359


>gi|28373070 sialyltransferase 6 isoform b [Homo sapiens]
          Length = 390

 Score =  230 bits (587), Expect = 1e-60
 Identities = 124/307 (40%), Positives = 185/307 (60%), Gaps = 6/307 (1%)

Query: 85  AQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKF 144
           A KYA    +  C+P +A   M  +F  R+S     F+  + +      ++ PPFG +  
Sbjct: 90  ATKYAN-FSEGACKPGYASALMTAIFP-RFSKPAPMFLDDSFRKWARIREFVPPFGIKGQ 147

Query: 145 SSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV 204
            + ++ +L +  E+ L   L +  CRRC+++G+GG+L    LG  ++ +D+V+RLNSAPV
Sbjct: 148 DNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV 207

Query: 205 EGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWV 264
           +G+ + VG+KTT+R+TYPEGA     +Y  + LFV   FK  DF WL+ +V KE +    
Sbjct: 208 KGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVS--A 265

Query: 265 RLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVV 324
              FWK VA ++P +P   RILNP  I+E AF ++      +   GR  N+PT+G +AV 
Sbjct: 266 SDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPF-NNGLMGRG-NIPTLGSVAVT 323

Query: 325 LATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVV 384
           +A H CDEV++AGFGYD++ P  PLHY+++  MAA+     HN+  E +FL KLVK  V+
Sbjct: 324 MALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVI 383

Query: 385 KDLSGGI 391
            DLS GI
Sbjct: 384 TDLSSGI 390


>gi|5454060 sialyltransferase 6 isoform j [Homo sapiens]
          Length = 375

 Score =  230 bits (587), Expect = 1e-60
 Identities = 124/307 (40%), Positives = 185/307 (60%), Gaps = 6/307 (1%)

Query: 85  AQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKF 144
           A KYA    +  C+P +A   M  +F  R+S     F+  + +      ++ PPFG +  
Sbjct: 75  ATKYAN-FSEGACKPGYASALMTAIFP-RFSKPAPMFLDDSFRKWARIREFVPPFGIKGQ 132

Query: 145 SSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV 204
            + ++ +L +  E+ L   L +  CRRC+++G+GG+L    LG  ++ +D+V+RLNSAPV
Sbjct: 133 DNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV 192

Query: 205 EGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWV 264
           +G+ + VG+KTT+R+TYPEGA     +Y  + LFV   FK  DF WL+ +V KE +    
Sbjct: 193 KGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVS--A 250

Query: 265 RLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVV 324
              FWK VA ++P +P   RILNP  I+E AF ++      +   GR  N+PT+G +AV 
Sbjct: 251 SDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPF-NNGLMGRG-NIPTLGSVAVT 308

Query: 325 LATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVV 384
           +A H CDEV++AGFGYD++ P  PLHY+++  MAA+     HN+  E +FL KLVK  V+
Sbjct: 309 MALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVI 368

Query: 385 KDLSGGI 391
            DLS GI
Sbjct: 369 TDLSSGI 375


>gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens]
          Length = 331

 Score =  168 bits (425), Expect = 9e-42
 Identities = 102/315 (32%), Positives = 164/315 (52%), Gaps = 13/315 (4%)

Query: 74  MHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAES 133
           +++V P  +KR  K  Q  L K   P FA    +LL  H++   L     +         
Sbjct: 28  VYWVAPVEMKRRNKI-QPCLSK---PAFA----SLLRFHQFHPFLCAADFRKIASLYGSD 79

Query: 134 KYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQF 193
           K+D P+G R  +   +  L  L   DL +      C++CVV+G+GG+L    LG  ++ +
Sbjct: 80  KFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSY 139

Query: 194 DVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQA 253
           DV+IR+N+ PV G+ E VG +TT R+ YPE      +    N   +   FK  D  WL  
Sbjct: 140 DVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLE 199

Query: 254 MVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDK 313
           ++  + +       FWK+ A  +  +P   RIL+P II+  A+++L +  P+     +  
Sbjct: 200 LLMGDKIN---TNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHF--PKVFPKNQKP 254

Query: 314 NVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETK 373
             PT G+IA+ LA ++C EV LAGF Y+ +  ++PLHY+ +  M+ MN    HNVT E  
Sbjct: 255 KHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQL 314

Query: 374 FLLKLVKEGVVKDLS 388
           FL  ++++ +V +L+
Sbjct: 315 FLKDIIEKNLVINLT 329


>gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Homo
           sapiens]
          Length = 329

 Score =  163 bits (412), Expect = 3e-40
 Identities = 95/258 (36%), Positives = 150/258 (58%), Gaps = 10/258 (3%)

Query: 133 SKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQ 192
           S Y+ P+G  K S  +   +  +    +P+++++  CRRCVV+G+G  L    LG  +N+
Sbjct: 78  SAYELPYG-TKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINK 136

Query: 193 FDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS-DLEYYSNDLFVAVLFKSVDFNWL 251
           +DVVIRLN+APV GY   VG+KTT+R+ YPE A     +E   + L V V FK++DF+W+
Sbjct: 137 YDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWI 196

Query: 252 QAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGR 311
           + ++  +     VR  FWKQ      + PK  RILNP  ++  A  +L     Q R   +
Sbjct: 197 ETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR---K 250

Query: 312 DKNVPTIGVIAVVLATHLCDEVSLAGFGY-DLNQPRTPLHYFDSQCMAAMNFQTMHNVTT 370
            K  PT G++A+ LA HLCD V +AGFGY D    +  +HY++   + +M   + HNV+ 
Sbjct: 251 IKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM-AGSGHNVSQ 309

Query: 371 ETKFLLKLVKEGVVKDLS 388
           E   + ++++ G +K+L+
Sbjct: 310 EALAIKRMLEMGAIKNLT 327


>gi|28373074 sialyltransferase 6 isoform d [Homo sapiens]
          Length = 277

 Score =  124 bits (312), Expect = 1e-28
 Identities = 65/174 (37%), Positives = 103/174 (59%), Gaps = 2/174 (1%)

Query: 85  AQKYAQQVLQKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKF 144
           A KYA    +  C+P +A   M  +F  R+S     F+  + +      ++ PPFG +  
Sbjct: 75  ATKYAN-FSEGACKPGYASALMTAIFP-RFSKPAPMFLDDSFRKWARIREFVPPFGIKGQ 132

Query: 145 SSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV 204
            + ++ +L +  E+ L   L +  CRRC+++G+GG+L    LG  ++ +D+V+RLNSAPV
Sbjct: 133 DNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV 192

Query: 205 EGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKE 258
           +G+ + VG+KTT+R+TYPEGA     +Y  + LFV   FK  DF WL+ +V KE
Sbjct: 193 KGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE 246



 Score = 32.7 bits (73), Expect = 0.59
 Identities = 15/26 (57%), Positives = 18/26 (69%)

Query: 366 HNVTTETKFLLKLVKEGVVKDLSGGI 391
           HN+  E +FL KLVK  V+ DLS GI
Sbjct: 252 HNIQREKEFLRKLVKARVITDLSSGI 277


>gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Homo
           sapiens]
          Length = 350

 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 78/321 (24%), Positives = 138/321 (42%), Gaps = 43/321 (13%)

Query: 45  LKCTLLVF----GVWILYILKLNYTTEECDMKKMHYVDPD------HVKRAQKYAQ-QVL 93
           +KC+L V+       +++I+ L +T     M  + Y+D         VK    YA  Q L
Sbjct: 1   MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRL 60

Query: 94  QKE--------CRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESK-----YDPPFG 140
            KE        CR        +  F+  +  ++ P   +   D   + +       P F 
Sbjct: 61  SKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFK 120

Query: 141 FRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLN 200
               +  ++ L +++P  +         CRRC V+G+ G L G   G  ++  + ++R+N
Sbjct: 121 SHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMN 180

Query: 201 SAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETL 260
            AP  G+ + VG++TT    YPE A        +N  FV V FK +D  W+ + +    +
Sbjct: 181 QAPTVGFEQDVGSRTTHHFMYPESAK----NLPANVSFVLVPFKVLDLLWIASALSTGQI 236

Query: 261 PFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGV 320
                 F +  V   + +  +  +I NP   K   +   +++E   R+       P+ G+
Sbjct: 237 -----RFTYAPVKSFLRVDKEKVQIYNPAFFK---YIHDRWTEHHGRY-------PSTGM 281

Query: 321 IAVVLATHLCDEVSLAGFGYD 341
           + +  A H+CDEV++ GFG D
Sbjct: 282 LVLFFALHVCDEVNVYGFGAD 302


>gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
           [Homo sapiens]
          Length = 340

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 56/173 (32%), Positives = 85/173 (49%), Gaps = 19/173 (10%)

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS 228
           CRRC V+G+ G L     G  ++  D V+R+N AP  G+   VG KTT  + YPE    S
Sbjct: 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE----S 194

Query: 229 DLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNP 288
             E   N   + V FK++D  W+ + +   T+        +  V  KI ++     I +P
Sbjct: 195 FRELGDNVSMILVPFKTIDLEWVVSAITTGTIS-----HTYIPVPAKIRVKQDKILIYHP 249

Query: 289 VIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYD 341
             IK   FD   + +   R+       P+ G+++V+ + H+CDEV L GFG D
Sbjct: 250 AFIK-YVFD--NWLQGHGRY-------PSTGILSVIFSMHVCDEVDLYGFGAD 292


>gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Homo
           sapiens]
          Length = 340

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 56/173 (32%), Positives = 85/173 (49%), Gaps = 19/173 (10%)

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS 228
           CRRC V+G+ G L     G  ++  D V+R+N AP  G+   VG KTT  + YPE    S
Sbjct: 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE----S 194

Query: 229 DLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNP 288
             E   N   + V FK++D  W+ + +   T+        +  V  KI ++     I +P
Sbjct: 195 FRELGDNVSMILVPFKTIDLEWVVSAITTGTIS-----HTYIPVPAKIRVKQDKILIYHP 249

Query: 289 VIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYD 341
             IK   FD   + +   R+       P+ G+++V+ + H+CDEV L GFG D
Sbjct: 250 AFIK-YVFD--NWLQGHGRY-------PSTGILSVIFSMHVCDEVDLYGFGAD 292


>gi|21264332 sialyltransferase 7A [Homo sapiens]
          Length = 600

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 68/272 (25%), Positives = 120/272 (44%), Gaps = 27/272 (9%)

Query: 135 YDPPFGFRKFS-SKVQTLLELLPEHDLPEHLKAKT------CRRCVVIGSGGILHGLELG 187
           + PPFGF + + S VQ ++   P     + L A        C  C V+G+GGIL+   +G
Sbjct: 321 FAPPFGFMELNYSLVQKVVTRFPPVPQQQLLLASLPAGSLRCITCAVVGNGGILNNSHMG 380

Query: 188 HTLNQFDVVIRLNSAPVEGYSEHVGNKT----------TIRMTYPEGAPLSDLEYYSNDL 237
             ++  D V RL+ A ++GY + VG +T          T  +         ++    +  
Sbjct: 381 QEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKDVR 440

Query: 238 FVAVLFKSVDFNWLQAMVKKETLP----FWVRLFFWKQVAEKIPLQPKHFRILNPVIIKE 293
           ++  L  + D+ WL+A++  +T+     FW R     Q A +  L    + +L+P  ++ 
Sbjct: 441 YLHFLEGTRDYEWLEALLMNQTVMSKNLFWFR--HRPQEAFREALHMDRYLLLHPDFLRY 498

Query: 294 TAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFD 353
                L+        W   +  PT G + ++ A  LCD+VS  GF  +    R   HY+D
Sbjct: 499 MKNRFLRSKTLDGAHWRIYR--PTTGALLLLTALQLCDQVSAYGFITE-GHERFSDHYYD 555

Query: 354 SQCMAAMNFQTMHNVTTETKFLLKLVKEGVVK 385
           +     + F   H+   E +   +L  EG+++
Sbjct: 556 TS-WKRLIFYINHDFKLEREVWKRLHDEGIIR 586


>gi|110815855 ST8 alpha-N-acetyl-neuraminide
           alpha-2,8-sialyltransferase 3 [Homo sapiens]
          Length = 380

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 79/326 (24%), Positives = 136/326 (41%), Gaps = 31/326 (9%)

Query: 74  MHYVDPDHVKRAQKYAQQVLQKECRPKFAKTSMALLFEHR---YSVDLLPFVQKAPKDSE 130
           + ++DP  V       Q++ +K  + KF +T  A L + +     VD++           
Sbjct: 65  LKFLDPSFVPITNSLTQELQEKPSKWKFNRT--AFLHQRQEILQHVDVIKNFSLTKNSVR 122

Query: 131 AESKYDPPFGFRKFSSKVQT-LLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHT 189
                   +   K+   +      LLP+      +  K    C V+G+ GIL G + G  
Sbjct: 123 IGQLMHYDYSSHKYVFSISNNFRSLLPD---VSPIMNKHYNICAVVGNSGILTGSQCGQE 179

Query: 190 LNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFN 249
           +++ D V R N AP E +   VG KT +    P     S LE Y N+L    L      N
Sbjct: 180 IDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNP-----SILEKYYNNL----LTIQDRNN 230

Query: 250 WLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAF--DILQYSEPQSR 307
           +  ++ K +    W+  FF+   A         F      +  + A+  +I+Q+    +R
Sbjct: 231 FFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQH---VNR 287

Query: 308 FWGRDKNVP---TIGVIAVVLATHLCDEVSLAG---FGYDLN-QPRTPLHYFDSQ-CMAA 359
           +W      P   + G++   LA+ +C+E+ L G   FG+D N +   P HY+D +     
Sbjct: 288 YWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFT 347

Query: 360 MNFQTMHNVTTETKFLLKLVKEGVVK 385
             +Q  H +  E + L ++  EG+ K
Sbjct: 348 TKWQESHQLPAEFQLLYRMHGEGLTK 373


>gi|5174677 ST8 alpha-N-acetyl-neuraminide
           alpha-2,8-sialyltransferase 2 [Homo sapiens]
          Length = 375

 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 70/255 (27%), Positives = 106/255 (41%), Gaps = 30/255 (11%)

Query: 149 QTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 208
           Q L ELLP       LK K    C ++G+ G+L     G  ++    VIR N APV+ Y+
Sbjct: 137 QNLYELLPR---TSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYA 193

Query: 209 EHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFF 268
             VG KT +    P     S ++    DL  A   + +    LQ +        W+  F 
Sbjct: 194 RDVGLKTDLVTMNP-----SVIQRAFEDLVNATWREKL----LQRLHSLNGSILWIPAFM 244

Query: 269 WKQVAEKIPLQPKHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGV 320
            +   E++         +N +I+K      TA+  L+       +W  +K     PT G+
Sbjct: 245 ARGGKERV-------EWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGL 297

Query: 321 IAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLK 377
           +   LAT  C ++ L G   F  D NQ     HY+DS      +  + H +  E K L  
Sbjct: 298 LMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKS 357

Query: 378 LVKEGVVKDLSGGID 392
           L ++G +K   G  D
Sbjct: 358 LHEQGALKLTVGQCD 372


>gi|192448440 sialyltransferase 7B [Homo sapiens]
          Length = 374

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 69/274 (25%), Positives = 117/274 (42%), Gaps = 30/274 (10%)

Query: 133 SKYDPPFGFRKFSSKV-QTLLELL----------PEHDLPEHLKAKTCRRCVVIGSGGIL 181
           S++  P+G+R  S +V  + L LL          P  D P       C RC V+G+GGIL
Sbjct: 106 SQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPK-----CIRCAVVGNGGIL 160

Query: 182 HGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYS------- 234
           +G   G  ++  D V RLN A ++G+   VG KT+           S + Y++       
Sbjct: 161 NGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVP 220

Query: 235 --NDL-FVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVII 291
              DL ++ +     D+  L++ +    +P  +                  F++L+P  I
Sbjct: 221 QGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFI 280

Query: 292 KETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHY 351
                  L+     + F   D  +P+ G + ++ A H CD+VS  GF    N  +   HY
Sbjct: 281 SYLTERFLKSKLINTHF--GDLYMPSTGALMLLTALHTCDQVSAYGF-ITSNYWKFSDHY 337

Query: 352 FDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVK 385
           F+ + M  + F   H+++ E      L K G+++
Sbjct: 338 FERK-MKPLIFYANHDLSLEAALWRDLHKAGILQ 370


>gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
           isoform a [Homo sapiens]
          Length = 529

 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 65/236 (27%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 164 LKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPE 223
           L  +  R C V+ S G +    LG  ++  D V+R NSAP  GY + VGNKTTIR+   +
Sbjct: 288 LHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ 347

Query: 224 GAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWK------------Q 271
                 L   S+    + L+K V       +V  +  P+   L  W             Q
Sbjct: 348 -----ILTNPSHHFIDSSLYKDV------ILVAWDPAPYSANLNLWYKKPDYNLFTPYIQ 396

Query: 272 VAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCD 331
             ++ P QP  F IL+P  I +  +DI+Q +  +        N P+ G I +++   +C 
Sbjct: 397 HRQRNPNQP--FYILHPKFIWQ-LWDIIQENTKEK----IQPNPPSSGFIGILIMMSMCR 449

Query: 332 EVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDL 387
           EV +  +   + Q     HY +    AA      H +  E K L++ +  G   DL
Sbjct: 450 EVHVYEYIPSVRQTEL-CHYHELYYDAACTLGAYHPLLYE-KLLVQRLNMGTQGDL 503


>gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
           isoform a [Homo sapiens]
          Length = 529

 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 65/236 (27%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 164 LKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPE 223
           L  +  R C V+ S G +    LG  ++  D V+R NSAP  GY + VGNKTTIR+   +
Sbjct: 288 LHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ 347

Query: 224 GAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWK------------Q 271
                 L   S+    + L+K V       +V  +  P+   L  W             Q
Sbjct: 348 -----ILTNPSHHFIDSSLYKDV------ILVAWDPAPYSANLNLWYKKPDYNLFTPYIQ 396

Query: 272 VAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCD 331
             ++ P QP  F IL+P  I +  +DI+Q +  +        N P+ G I +++   +C 
Sbjct: 397 HRQRNPNQP--FYILHPKFIWQ-LWDIIQENTKEK----IQPNPPSSGFIGILIMMSMCR 449

Query: 332 EVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDL 387
           EV +  +   + Q     HY +    AA      H +  E K L++ +  G   DL
Sbjct: 450 EVHVYEYIPSVRQTEL-CHYHELYYDAACTLGAYHPLLYE-KLLVQRLNMGTQGDL 503


>gi|5031999 ST8 alpha-N-acetyl-neuraminide
           alpha-2,8-sialyltransferase 4 isoform a [Homo sapiens]
          Length = 359

 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 66/250 (26%), Positives = 100/250 (40%), Gaps = 30/250 (12%)

Query: 151 LLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEH 210
           L  LLPE    ++ + KTC    V+G+ GIL   E G  ++  + VIR N APV  ++  
Sbjct: 124 LHSLLPEVSPMKNRRFKTC---AVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD 180

Query: 211 VGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWK 270
           VG K+      P     +         F     +S    ++  +        W+  F  K
Sbjct: 181 VGTKSDFITMNPSVVQRA---------FGGFRNESDREKFVHRLSMLNDSVLWIPAFMVK 231

Query: 271 QVAEKIPLQPKHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIA 322
                     KH   +N +I+K      TA+  L+       +W  +K     P+ G++ 
Sbjct: 232 G-------GEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLM 284

Query: 323 VVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLV 379
             LAT  CDE+ L G   F  DLN      HY+D       +  + H +  E K L  L 
Sbjct: 285 YTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLH 344

Query: 380 KEGVVKDLSG 389
             G +K  +G
Sbjct: 345 NRGALKLTTG 354


>gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
           isoform a [Homo sapiens]
          Length = 406

 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 67/237 (28%), Positives = 99/237 (41%), Gaps = 37/237 (15%)

Query: 165 KAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR-----M 219
           KA    RC V+ S G L   +LG  ++  D V+R N AP   + + VG KTTIR     +
Sbjct: 177 KAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQL 236

Query: 220 TYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVR----LFF--WKQVA 273
              E   L D  Y    L V          W    V    +P W +     FF  +K   
Sbjct: 237 VTTEKRFLKDSLYNEGILIV----------W-DPSVYHSDIPKWYQNPDYNFFNNYKTYR 285

Query: 274 EKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEV 333
           +  P QP  F IL P +  E  +DILQ   P+        N P+ G++ +++   LCD+V
Sbjct: 286 KLHPNQP--FYILKPQMPWE-LWDILQEISPEE----IQPNPPSSGMLGIIIMMTLCDQV 338

Query: 334 SLAGFGYDLNQPRTPLHY---FDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDL 387
            +  F     +     +Y   FDS C        ++      K L+K + +G  +D+
Sbjct: 339 DIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE-----KNLVKHLNQGTDEDI 390


>gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
           isoform a [Homo sapiens]
          Length = 406

 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 67/237 (28%), Positives = 99/237 (41%), Gaps = 37/237 (15%)

Query: 165 KAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR-----M 219
           KA    RC V+ S G L   +LG  ++  D V+R N AP   + + VG KTTIR     +
Sbjct: 177 KAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQL 236

Query: 220 TYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVR----LFF--WKQVA 273
              E   L D  Y    L V          W    V    +P W +     FF  +K   
Sbjct: 237 VTTEKRFLKDSLYNEGILIV----------W-DPSVYHSDIPKWYQNPDYNFFNNYKTYR 285

Query: 274 EKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEV 333
           +  P QP  F IL P +  E  +DILQ   P+        N P+ G++ +++   LCD+V
Sbjct: 286 KLHPNQP--FYILKPQMPWE-LWDILQEISPEE----IQPNPPSSGMLGIIIMMTLCDQV 338

Query: 334 SLAGFGYDLNQPRTPLHY---FDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDL 387
            +  F     +     +Y   FDS C        ++      K L+K + +G  +D+
Sbjct: 339 DIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE-----KNLVKHLNQGTDEDI 390


>gi|13569938 sialyltransferase 7E [Homo sapiens]
          Length = 336

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 50/199 (25%), Positives = 86/199 (43%), Gaps = 32/199 (16%)

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS 228
           CR C ++ S G L     G  ++Q + VIR+N AP  GY   VGN+T++R+         
Sbjct: 93  CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRV--------- 143

Query: 229 DLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNP 288
                ++     +L    D   L  + +     FW    + ++  +       H  +L+ 
Sbjct: 144 ----IAHSSIQRILRNRHD---LLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLH--LLSQ 194

Query: 289 VIIKETAFDI-----LQYSEPQSRFWGRDKNVP----TIGVIAVVLATHLCDEVSLAG-- 337
           V+ +  AF I     LQ+ E   +  G+D+ +     + G   + +A  LCD +++ G  
Sbjct: 195 VLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMV 254

Query: 338 ---FGYDLNQPRTPLHYFD 353
              F  D N P  P HY++
Sbjct: 255 PPDFCRDPNHPSVPYHYYE 273


>gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
           isoform b [Homo sapiens]
          Length = 466

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 50/166 (30%), Positives = 72/166 (43%), Gaps = 32/166 (19%)

Query: 164 LKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPE 223
           L  +  R C V+ S G +    LG  ++  D V+R NSAP  GY + VGNKTTIR+   +
Sbjct: 288 LHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ 347

Query: 224 GAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWK------------Q 271
                 L   S+    + L+K V       +V  +  P+   L  W             Q
Sbjct: 348 -----ILTNPSHHFIDSSLYKDV------ILVAWDPAPYSANLNLWYKKPDYNLFTPYIQ 396

Query: 272 VAEKIPLQPKHFRILNPV-------IIKETAFDILQYSEPQSRFWG 310
             ++ P QP  F IL+P        II+E   + +Q + P S F G
Sbjct: 397 HRQRNPNQP--FYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIG 440


>gi|21361444 sialytransferase 7F [Homo sapiens]
          Length = 333

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 23/51 (45%), Positives = 32/51 (62%)

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 219
           C +CV++ S   L G +LG  + + +  IR+N AP  GYS  VGNKTT R+
Sbjct: 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRV 155


>gi|28373092 sialyltransferase 7D isoform a [Homo sapiens]
          Length = 302

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 49/201 (24%), Positives = 78/201 (38%), Gaps = 26/201 (12%)

Query: 164 LKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPE 223
           L  + CR C V+ S G + G  LG  ++  + V R+N AP  G+   VG ++T+R+    
Sbjct: 68  LVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHT 127

Query: 224 GAPLSDLEYYSN------DLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIP 277
             PL  L  YS+      D    V  +    + +       TL    R++   QV     
Sbjct: 128 SVPLL-LRNYSHYFQKARDTLYMVWGQGRHMDRVLGGRTYRTLLQLTRMYPGLQV---YT 183

Query: 278 LQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAG 337
              +     + +   ET  +  Q     S  W             ++LA  LC+E+ + G
Sbjct: 184 FTERMMAYCDQIFQDETGKNRRQSGSFLSTGW-----------FTMILALELCEEIVVYG 232

Query: 338 FGYD-----LNQPRTPLHYFD 353
              D      + P  P HYF+
Sbjct: 233 MVSDSYCREKSHPSVPYHYFE 253


>gi|28373101 ST8 alpha-N-acetyl-neuraminide
           alpha-2,8-sialyltransferase 5 [Homo sapiens]
          Length = 376

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 56/227 (24%), Positives = 90/227 (39%), Gaps = 51/227 (22%)

Query: 149 QTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGY 207
           Q +  + P+ D+P +      ++C V+G+GGIL     G  +N  D V R N  P+ E Y
Sbjct: 144 QEIFRMFPK-DMPYY--RSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKY 200

Query: 208 SEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLF 267
           +  VG KT +    P                +   F  ++         K   PF+  L 
Sbjct: 201 TMDVGVKTDVVTVNPS--------------IITERFHKLE---------KWRRPFYRVLQ 237

Query: 268 FWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQ-------------SRFW----G 310
            ++  +    L P  +   N  +     + +  +  PQ             SR+W     
Sbjct: 238 VYENAS---VLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGV 294

Query: 311 RDKNVPTIGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDS 354
           R K + T G+I V  A  LC+EV L GF  + +N     +  HY+D+
Sbjct: 295 RAKRIST-GLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDN 340


>gi|229892273 sialyltransferase 7C isoform 1 [Homo sapiens]
          Length = 305

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 19/59 (32%), Positives = 34/59 (57%)

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 227
           C  C ++ + G + G ++G+ +++   + R+N+AP +GY E VG  T IR+      PL
Sbjct: 77  CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPL 135


>gi|229892275 sialyltransferase 7C isoform 2 [Homo sapiens]
          Length = 210

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 19/59 (32%), Positives = 34/59 (57%)

Query: 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 227
           C  C ++ + G + G ++G+ +++   + R+N+AP +GY E VG  T IR+      PL
Sbjct: 77  CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPL 135


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,114,579
Number of Sequences: 37866
Number of extensions: 656183
Number of successful extensions: 1271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1200
Number of HSP's gapped (non-prelim): 45
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.