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Search of human proteins with 9910476
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9910476 p21-activated kinase 6 [Homo sapiens]
(681 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|191252782 p21-activated kinase 6 [Homo sapiens] 1372 0.0
gi|191252780 p21-activated kinase 6 [Homo sapiens] 1372 0.0
gi|9910476 p21-activated kinase 6 [Homo sapiens] 1372 0.0
gi|29826329 p21-activated kinase 7 [Homo sapiens] 559 e-159
gi|24308191 p21-activated kinase 7 [Homo sapiens] 559 e-159
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 548 e-156
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 548 e-156
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 548 e-156
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 453 e-127
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 453 e-127
gi|32483399 p21-activated kinase 2 [Homo sapiens] 311 2e-84
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 302 6e-82
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 302 6e-82
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 302 6e-82
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 302 6e-82
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 302 6e-82
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 302 6e-82
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 299 5e-81
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 290 4e-78
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 203 5e-52
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 203 5e-52
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 202 1e-51
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 201 2e-51
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 198 2e-50
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 197 2e-50
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 197 2e-50
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 194 2e-49
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 194 2e-49
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 194 2e-49
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 193 5e-49
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 1372 bits (3550), Expect = 0.0
Identities = 681/681 (100%), Positives = 681/681 (100%)
Query: 1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT 60
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT
Sbjct: 1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT 60
Query: 61 RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE 120
RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE
Sbjct: 61 RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE 120
Query: 121 HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL 180
HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL
Sbjct: 121 HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL 180
Query: 181 GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR 240
GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR
Sbjct: 181 GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR 240
Query: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
Sbjct: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
Query: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS 360
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS
Sbjct: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS 360
Query: 361 TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI 420
TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI
Sbjct: 361 TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI 420
Query: 421 VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL 480
VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL
Sbjct: 421 VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL 480
Query: 481 MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV 540
MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV
Sbjct: 481 MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV 540
Query: 541 KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP 600
KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP
Sbjct: 541 KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP 600
Query: 601 YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 660
YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ
Sbjct: 601 YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 660
Query: 661 TGLPECLVPLIQLYRKQTSTC 681
TGLPECLVPLIQLYRKQTSTC
Sbjct: 661 TGLPECLVPLIQLYRKQTSTC 681
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 1372 bits (3550), Expect = 0.0
Identities = 681/681 (100%), Positives = 681/681 (100%)
Query: 1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT 60
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT
Sbjct: 1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT 60
Query: 61 RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE 120
RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE
Sbjct: 61 RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE 120
Query: 121 HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL 180
HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL
Sbjct: 121 HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL 180
Query: 181 GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR 240
GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR
Sbjct: 181 GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR 240
Query: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
Sbjct: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
Query: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS 360
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS
Sbjct: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS 360
Query: 361 TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI 420
TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI
Sbjct: 361 TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI 420
Query: 421 VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL 480
VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL
Sbjct: 421 VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL 480
Query: 481 MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV 540
MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV
Sbjct: 481 MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV 540
Query: 541 KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP 600
KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP
Sbjct: 541 KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP 600
Query: 601 YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 660
YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ
Sbjct: 601 YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 660
Query: 661 TGLPECLVPLIQLYRKQTSTC 681
TGLPECLVPLIQLYRKQTSTC
Sbjct: 661 TGLPECLVPLIQLYRKQTSTC 681
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 1372 bits (3550), Expect = 0.0
Identities = 681/681 (100%), Positives = 681/681 (100%)
Query: 1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT 60
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT
Sbjct: 1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT 60
Query: 61 RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE 120
RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE
Sbjct: 61 RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE 120
Query: 121 HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL 180
HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL
Sbjct: 121 HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL 180
Query: 181 GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR 240
GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR
Sbjct: 181 GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR 240
Query: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
Sbjct: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
Query: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS 360
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS
Sbjct: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS 360
Query: 361 TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI 420
TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI
Sbjct: 361 TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI 420
Query: 421 VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL 480
VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL
Sbjct: 421 VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL 480
Query: 481 MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV 540
MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV
Sbjct: 481 MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV 540
Query: 541 KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP 600
KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP
Sbjct: 541 KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP 600
Query: 601 YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 660
YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ
Sbjct: 601 YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 660
Query: 661 TGLPECLVPLIQLYRKQTSTC 681
TGLPECLVPLIQLYRKQTSTC
Sbjct: 661 TGLPECLVPLIQLYRKQTSTC 681
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 559 bits (1441), Expect = e-159
Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT RPKP+VDPS IT +Q
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114
L PMKT+VRG+ + I+GLL D +SV SN+LR SP + + A+
Sbjct: 64 LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
Query: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164
G + ++++ D Y E++ DP+ Y + GH +M E
Sbjct: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
Query: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207
V P + L+ ++ S E+Q AS L Q +P +
Sbjct: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
Query: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261
+G ++ + ++ + RP+S + SP P R+ S
Sbjct: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
Query: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321
+ + A+A + PQ +S+ P+ P + K + + PL
Sbjct: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
Query: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369
+ SDT P K ++ +G P+G + H + +S+ Y+
Sbjct: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
Query: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422
P + G+ + + V+HEQF+AAL++VV GDPR L +++KIGEGSTGIVC
Sbjct: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
Query: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482
+A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
Query: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542
FL+GGALTDIV+ R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
Query: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602
SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
Query: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662
++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL G
Sbjct: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
Query: 663 LPECLVPLIQLYR 675
P C+VPL++ YR
Sbjct: 705 PPSCIVPLMRQYR 717
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 559 bits (1441), Expect = e-159
Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT RPKP+VDPS IT +Q
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114
L PMKT+VRG+ + I+GLL D +SV SN+LR SP + + A+
Sbjct: 64 LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
Query: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164
G + ++++ D Y E++ DP+ Y + GH +M E
Sbjct: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
Query: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207
V P + L+ ++ S E+Q AS L Q +P +
Sbjct: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
Query: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261
+G ++ + ++ + RP+S + SP P R+ S
Sbjct: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
Query: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321
+ + A+A + PQ +S+ P+ P + K + + PL
Sbjct: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
Query: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369
+ SDT P K ++ +G P+G + H + +S+ Y+
Sbjct: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
Query: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422
P + G+ + + V+HEQF+AAL++VV GDPR L +++KIGEGSTGIVC
Sbjct: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
Query: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482
+A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
Query: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542
FL+GGALTDIV+ R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
Query: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602
SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
Query: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662
++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL G
Sbjct: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
Query: 663 LPECLVPLIQLYR 675
P C+VPL++ YR
Sbjct: 705 PPSCIVPLMRQYR 717
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 548 bits (1411), Expect = e-156
Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
KT+VRGS DG ++ LL++ + +SV SN+LR SP RA+ + +E
Sbjct: 64 PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
Query: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183
T ++ R H GG+ + P P+S R S GP
Sbjct: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
Query: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241
E + P + P GT + A+ RP + + T P
Sbjct: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
Query: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301
G +G P AP S G +SS RPP
Sbjct: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
Query: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361
+A+ PS G P + +P APA PG SP P+
Sbjct: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
Query: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421
V+HEQF+AAL++VVD GDPR LD+++KIGEGSTGIV
Sbjct: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
Query: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481
C+A + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
Query: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541
EFL+GGALTDIV+ R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
Query: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601
LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR Y EVDIWSLGIMVIEMVDGEPPY
Sbjct: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
Query: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661
F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL +
Sbjct: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
Query: 662 GLPECLVPLIQLYR 675
G P +VPL++ R
Sbjct: 576 GPPASIVPLMRQNR 589
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 548 bits (1411), Expect = e-156
Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
KT+VRGS DG ++ LL++ + +SV SN+LR SP RA+ + +E
Sbjct: 64 PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
Query: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183
T ++ R H GG+ + P P+S R S GP
Sbjct: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
Query: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241
E + P + P GT + A+ RP + + T P
Sbjct: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
Query: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301
G +G P AP S G +SS RPP
Sbjct: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
Query: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361
+A+ PS G P + +P APA PG SP P+
Sbjct: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
Query: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421
V+HEQF+AAL++VVD GDPR LD+++KIGEGSTGIV
Sbjct: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
Query: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481
C+A + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
Query: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541
EFL+GGALTDIV+ R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
Query: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601
LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR Y EVDIWSLGIMVIEMVDGEPPY
Sbjct: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
Query: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661
F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL +
Sbjct: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
Query: 662 GLPECLVPLIQLYR 675
G P +VPL++ R
Sbjct: 576 GPPASIVPLMRQNR 589
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 548 bits (1411), Expect = e-156
Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
KT+VRGS DG ++ LL++ + +SV SN+LR SP RA+ + +E
Sbjct: 64 PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
Query: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183
T ++ R H GG+ + P P+S R S GP
Sbjct: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
Query: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241
E + P + P GT + A+ RP + + T P
Sbjct: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
Query: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301
G +G P AP S G +SS RPP
Sbjct: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
Query: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361
+A+ PS G P + +P APA PG SP P+
Sbjct: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
Query: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421
V+HEQF+AAL++VVD GDPR LD+++KIGEGSTGIV
Sbjct: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
Query: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481
C+A + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
Query: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541
EFL+GGALTDIV+ R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
Query: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601
LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR Y EVDIWSLGIMVIEMVDGEPPY
Sbjct: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
Query: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661
F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL +
Sbjct: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
Query: 662 GLPECLVPLIQLYR 675
G P +VPL++ R
Sbjct: 576 GPPASIVPLMRQNR 589
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 453 bits (1166), Expect = e-127
Identities = 245/403 (60%), Positives = 292/403 (72%), Gaps = 14/403 (3%)
Query: 275 SSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFS-PLTTSDTSSPQKSL 333
S+ +P P +S +P P VA P+ G + P ++S +S P
Sbjct: 46 SARRPKPLVDPACITSIQPGAPKGEPHDVA-----PNGPSAGGLAIPQSSSSSSRPPTRA 100
Query: 334 RTAPATGQL-PGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKA 392
R AP+ G L P S P +P P P + V+HEQF+A
Sbjct: 101 RGAPSPGVLGPHASEPQLAP-------PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 153
Query: 393 ALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNE 452
AL++VVD GDPR LD+++KIGEGSTGIVC+A + SG+ VAVK MDLRKQQRRELLFNE
Sbjct: 154 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 213
Query: 453 VVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQ 512
VVIMRDYQH NVVEMY SYLVG+ELWV+MEFL+GGALTDIV+ R+NEEQIA VC AVLQ
Sbjct: 214 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQ 273
Query: 513 ALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEV 572
AL+ LHAQGVIHRDIKSDSILLT DGRVKLSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+
Sbjct: 274 ALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEL 333
Query: 573 ISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLR 632
ISR Y EVDIWSLGIMVIEMVDGEPPYF++ P++AMK +RD+ PP+LKN HKVSP L+
Sbjct: 334 ISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLK 393
Query: 633 DFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYR 675
FL+R+LVRDP +RATA ELL HPFL + G P +VPL++ R
Sbjct: 394 GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 436
Score = 89.0 bits (219), Expect = 1e-17
Identities = 55/125 (44%), Positives = 74/125 (59%), Gaps = 11/125 (8%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ+++ ++ RRPKP+VDP+ IT +Q
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
K P D +G L++ S++ R PT R A S G+LG A
Sbjct: 64 PGAPK------GEPHDVAPNG--PSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPH--A 113
Query: 124 TDPDM 128
++P +
Sbjct: 114 SEPQL 118
Score = 30.0 bits (66), Expect = 7.4
Identities = 27/107 (25%), Positives = 41/107 (38%), Gaps = 25/107 (23%)
Query: 197 ACLQSSPPGASP-------PTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSP 249
AC+ S PGA P G + G+ + S +RP + G+ + G + P
Sbjct: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEP 116
Query: 250 KTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQK 296
+ L+ A P + + PGPP P S R PQ+
Sbjct: 117 Q---------------LAPPACTPAAPAVPGPP---GPRSPQREPQR 145
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 453 bits (1166), Expect = e-127
Identities = 245/403 (60%), Positives = 292/403 (72%), Gaps = 14/403 (3%)
Query: 275 SSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFS-PLTTSDTSSPQKSL 333
S+ +P P +S +P P VA P+ G + P ++S +S P
Sbjct: 46 SARRPKPLVDPACITSIQPGAPKGEPHDVA-----PNGPSAGGLAIPQSSSSSSRPPTRA 100
Query: 334 RTAPATGQL-PGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKA 392
R AP+ G L P S P +P P P + V+HEQF+A
Sbjct: 101 RGAPSPGVLGPHASEPQLAP-------PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 153
Query: 393 ALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNE 452
AL++VVD GDPR LD+++KIGEGSTGIVC+A + SG+ VAVK MDLRKQQRRELLFNE
Sbjct: 154 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 213
Query: 453 VVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQ 512
VVIMRDYQH NVVEMY SYLVG+ELWV+MEFL+GGALTDIV+ R+NEEQIA VC AVLQ
Sbjct: 214 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQ 273
Query: 513 ALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEV 572
AL+ LHAQGVIHRDIKSDSILLT DGRVKLSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+
Sbjct: 274 ALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEL 333
Query: 573 ISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLR 632
ISR Y EVDIWSLGIMVIEMVDGEPPYF++ P++AMK +RD+ PP+LKN HKVSP L+
Sbjct: 334 ISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLK 393
Query: 633 DFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYR 675
FL+R+LVRDP +RATA ELL HPFL + G P +VPL++ R
Sbjct: 394 GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 436
Score = 89.0 bits (219), Expect = 1e-17
Identities = 55/125 (44%), Positives = 74/125 (59%), Gaps = 11/125 (8%)
Query: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ+++ ++ RRPKP+VDP+ IT +Q
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
Query: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
K P D +G L++ S++ R PT R A S G+LG A
Sbjct: 64 PGAPK------GEPHDVAPNG--PSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPH--A 113
Query: 124 TDPDM 128
++P +
Sbjct: 114 SEPQL 118
Score = 30.0 bits (66), Expect = 7.4
Identities = 27/107 (25%), Positives = 41/107 (38%), Gaps = 25/107 (23%)
Query: 197 ACLQSSPPGASP-------PTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSP 249
AC+ S PGA P G + G+ + S +RP + G+ + G + P
Sbjct: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEP 116
Query: 250 KTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQK 296
+ L+ A P + + PGPP P S R PQ+
Sbjct: 117 Q---------------LAPPACTPAAPAVPGPP---GPRSPQREPQR 145
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 311 bits (796), Expect = 2e-84
Identities = 168/391 (42%), Positives = 245/391 (62%), Gaps = 27/391 (6%)
Query: 290 SFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPA 349
SF PP+KD PS P+ GT +P ++ + TAP P
Sbjct: 141 SFTPPEKDGFPS------GTPALNAKGTEAPAVVTEEEDDDEE--TAP----------PV 182
Query: 350 GSPRTWHAQ-ISTSNLYLPQDPTVAKGALAGEDTGV--------VTHEQFKAALRMVVDQ 400
+PR H + I T ++ P V + G + +T E+ LR +V
Sbjct: 183 IAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSI 242
Query: 401 GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQ 460
GDP+ Y KIG+G++G V A + G++VA+K ++L+KQ ++EL+ NE+++M++ +
Sbjct: 243 GDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELK 302
Query: 461 HFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQ 520
+ N+V SYLVG+EL+V+ME+L GG+LTD+V++ ++E QIA VC LQAL +LHA
Sbjct: 303 NPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHAN 362
Query: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT 580
VIHRDIKSD++LL ++G VKL+DFGFCAQI+ + KR ++VGTPYWMAPEV++R Y
Sbjct: 363 QVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 422
Query: 581 EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLV 640
+VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N K+SP+ RDFL R L
Sbjct: 423 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLE 482
Query: 641 RDPQERATAQELLDHPFLLQTGLPECLVPLI 671
D ++R +A+ELL HPFL L PLI
Sbjct: 483 MDVEKRGSAKELLQHPFLKLAKPLSSLTPLI 513
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 65 KKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQT 108
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 302 bits (774), Expect = 6e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
A PSS+K P P S +++ + ++P +P S +
Sbjct: 168 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 219
Query: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 220 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 267
Query: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 268 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 327
Query: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 328 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 387
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 447
Query: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 448 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 507
Query: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 508 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
Score = 47.8 bits (112), Expect = 3e-05
Identities = 22/59 (37%), Positives = 31/59 (52%), Gaps = 15/59 (25%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFV---------------GLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQT 119
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 302 bits (774), Expect = 6e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
A PSS+K P P S +++ + ++P +P S +
Sbjct: 174 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 225
Query: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 226 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 273
Query: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 274 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 333
Query: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 334 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 393
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 394 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 453
Query: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 454 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 513
Query: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 514 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 21/65 (32%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKF---------------------VGLPPQWQ 41
+KK+K+RPEIS P +F+H +H FD G+F +G+P QW
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
Query: 42 NILDT 46
+L T
Sbjct: 121 RLLQT 125
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 302 bits (774), Expect = 6e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
A PSS+K P P S +++ + ++P +P S +
Sbjct: 189 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 240
Query: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 241 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 288
Query: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 289 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 348
Query: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 349 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 408
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 409 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 468
Query: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 469 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 528
Query: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 529 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 568
Score = 44.7 bits (104), Expect = 3e-04
Identities = 18/37 (48%), Positives = 25/37 (67%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQ 39
+KK+K+RPEIS P +F+H +H FD G+F P Q
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 302 bits (774), Expect = 6e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
A PSS+K P P S +++ + ++P +P S +
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 204
Query: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 205 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 252
Query: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 253 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 312
Query: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 313 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 372
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 373 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 432
Query: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 433 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 492
Query: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 493 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQT 104
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 302 bits (774), Expect = 6e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
A PSS+K P P S +++ + ++P +P S +
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 204
Query: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 205 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 252
Query: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 253 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 312
Query: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 313 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 372
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 373 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 432
Query: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 433 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 492
Query: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 493 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQT 104
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 302 bits (774), Expect = 6e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
A PSS+K P P S +++ + ++P +P S +
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 204
Query: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 205 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 252
Query: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 253 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 312
Query: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 313 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 372
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 373 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 432
Query: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 433 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 492
Query: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 493 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQT 104
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 299 bits (766), Expect = 5e-81
Identities = 143/294 (48%), Positives = 211/294 (71%)
Query: 385 VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ 444
++ E+ LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q
Sbjct: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
Query: 445 RRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 504
++EL+ NE+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA
Sbjct: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
Query: 505 TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGT 564
VC LQAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGT
Sbjct: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
Query: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
PYWMAPEV++R Y +VDIWSLGIM IEM++GEPPY +++P++A+ + + P+L+N
Sbjct: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
Query: 625 HKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQT 678
K+S + RDFL R L D ++R +A+ELL H FL L PLI ++ T
Sbjct: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT 541
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 66 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQT 109
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 290 bits (741), Expect = 4e-78
Identities = 135/269 (50%), Positives = 201/269 (74%)
Query: 385 VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ 444
++ E+ LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q
Sbjct: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
Query: 445 RRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 504
++EL+ NE+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA
Sbjct: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
Query: 505 TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGT 564
VC LQAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGT
Sbjct: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
Query: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
PYWMAPEV++R Y +VDIWSLGIM IEM++GEPPY +++P++A+ + + P+L+N
Sbjct: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
Query: 625 HKVSPVLRDFLERMLVRDPQERATAQELL 653
K+S + RDFL R L D ++R +A+ELL
Sbjct: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 66 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQT 109
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 203 bits (516), Expect = 5e-52
Identities = 117/285 (41%), Positives = 170/285 (59%), Gaps = 8/285 (2%)
Query: 391 KAALRMVVD--QGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL 448
+A LR D + +P+ + ++G G+ G V AR H+G AVK++ L L
Sbjct: 2 EAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL 61
Query: 449 LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVC 507
+ E+ ++++ +H N+V + SYL E+LW+ ME+ GG+L DI L+E QIA VC
Sbjct: 62 IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVC 121
Query: 508 EAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYW 567
LQ LAYLH +G +HRDIK +ILLT G VKL+DFG A+I+ + KRKS +GTPYW
Sbjct: 122 RETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
Query: 568 MAPEVIS---RSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLK 622
MAPEV + Y DIW++GI IE+ + +PP F P++A+ + S PPKLK
Sbjct: 182 MAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLK 241
Query: 623 NSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECL 667
+ K S +F++ L ++P++R TA+ LL H F+ Q GL L
Sbjct: 242 DKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRAL 286
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 203 bits (516), Expect = 5e-52
Identities = 117/285 (41%), Positives = 170/285 (59%), Gaps = 8/285 (2%)
Query: 391 KAALRMVVD--QGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL 448
+A LR D + +P+ + ++G G+ G V AR H+G AVK++ L L
Sbjct: 2 EAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL 61
Query: 449 LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVC 507
+ E+ ++++ +H N+V + SYL E+LW+ ME+ GG+L DI L+E QIA VC
Sbjct: 62 IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVC 121
Query: 508 EAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYW 567
LQ LAYLH +G +HRDIK +ILLT G VKL+DFG A+I+ + KRKS +GTPYW
Sbjct: 122 RETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
Query: 568 MAPEVIS---RSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLK 622
MAPEV + Y DIW++GI IE+ + +PP F P++A+ + S PPKLK
Sbjct: 182 MAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLK 241
Query: 623 NSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECL 667
+ K S +F++ L ++P++R TA+ LL H F+ Q GL L
Sbjct: 242 DKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRAL 286
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 202 bits (513), Expect = 1e-51
Identities = 103/258 (39%), Positives = 157/258 (60%), Gaps = 4/258 (1%)
Query: 403 PRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF 462
P + D K+GEGS G V A K +G+ VA+K + + + + E+ IM+
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--IIKEISIMQQCDSP 83
Query: 463 NVVEMYKSYLVGEELWVLMEFLQGGALTDIVS--QVRLNEEQIATVCEAVLQALAYLHAQ 520
+VV+ Y SY +LW++ME+ G+++DI+ L E++IAT+ ++ L+ L YLH
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143
Query: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT 580
IHRDIK+ +ILL +G KL+DFG Q++ + KR +++GTP+WMAPEVI Y
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203
Query: 581 EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLV 640
DIWSLGI IEM +G+PPY P++A+ + +PPP + S DF+++ LV
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263
Query: 641 RDPQERATAQELLDHPFL 658
+ P++RATA +LL HPF+
Sbjct: 264 KSPEQRATATQLLQHPFV 281
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 201 bits (511), Expect = 2e-51
Identities = 104/258 (40%), Positives = 157/258 (60%), Gaps = 4/258 (1%)
Query: 403 PRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF 462
P + D K+GEGS G V A K SG+ VA+K + + + + E+ IM+
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSP 80
Query: 463 NVVEMYKSYLVGEELWVLMEFLQGGALTDIVS--QVRLNEEQIATVCEAVLQALAYLHAQ 520
VV+ Y SY +LW++ME+ G+++DI+ L E++IAT+ ++ L+ L YLH
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140
Query: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT 580
IHRDIK+ +ILL +G KL+DFG Q++ + KR +++GTP+WMAPEVI Y
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 200
Query: 581 EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLV 640
DIWSLGI IEM +G+PPY P++A+ + +PPP + S DF+++ LV
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 260
Query: 641 RDPQERATAQELLDHPFL 658
++P++RATA +LL HPF+
Sbjct: 261 KNPEQRATATQLLQHPFI 278
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 198 bits (503), Expect = 2e-50
Identities = 108/255 (42%), Positives = 161/255 (63%), Gaps = 6/255 (2%)
Query: 412 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSY 471
+IG G+ G V AR ++G A+K++ L + ++ E+++M+D +H N+V + SY
Sbjct: 21 RIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSY 80
Query: 472 LVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSD 530
L ++LW+ MEF GG+L DI L+E QIA V LQ L YLH++G +HRDIK
Sbjct: 81 LRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGA 140
Query: 531 SILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS---RSLYATEVDIWSL 587
+ILLT +G VKL+DFG AQI+ + KRKS +GTPYWMAPEV + + Y D+W++
Sbjct: 141 NILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAV 200
Query: 588 GIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLKNSHKVSPVLRDFLERMLVRDPQE 645
GI IE+ + +PP F P++A+ + S PPKLK+ K S F++ L ++P++
Sbjct: 201 GITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKK 260
Query: 646 RATAQELLDHPFLLQ 660
R TA++LL HPF+ Q
Sbjct: 261 RPTAEKLLQHPFVTQ 275
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 197 bits (502), Expect = 2e-50
Identities = 108/279 (38%), Positives = 168/279 (60%), Gaps = 4/279 (1%)
Query: 400 QGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRD 458
+ DP L KIG+GS G V + + + VA+K++DL + + E + E+ ++
Sbjct: 17 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 459 YQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLH 518
V + Y SYL +LW++ME+L GG+ D++ L+E QIAT+ +L+ L YLH
Sbjct: 77 CDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 136
Query: 519 AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLY 578
++ IHRDIK+ ++LL+ G VKL+DFG Q++ KR + VGTP+WMAPEVI +S Y
Sbjct: 137 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 196
Query: 579 ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERM 638
++ DIWSLGI IE+ GEPP+ P++ + + + PP L+ ++ S L++F+E
Sbjct: 197 DSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNY--SKPLKEFVEAC 254
Query: 639 LVRDPQERATAQELLDHPFLLQTG-LPECLVPLIQLYRK 676
L ++P R TA+ELL H F+L+ L LI Y++
Sbjct: 255 LNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKR 293
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 197 bits (502), Expect = 2e-50
Identities = 108/279 (38%), Positives = 168/279 (60%), Gaps = 4/279 (1%)
Query: 400 QGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRD 458
+ DP L KIG+GS G V + + + VA+K++DL + + E + E+ ++
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQ 88
Query: 459 YQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLH 518
V + Y SYL +LW++ME+L GG+ D++ L+E QIAT+ +L+ L YLH
Sbjct: 89 CDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 148
Query: 519 AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLY 578
++ IHRDIK+ ++LL+ G VKL+DFG Q++ KR + VGTP+WMAPEVI +S Y
Sbjct: 149 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 208
Query: 579 ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERM 638
++ DIWSLGI IE+ GEPP+ P++ + + + PP L+ ++ S L++F+E
Sbjct: 209 DSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNY--SKPLKEFVEAC 266
Query: 639 LVRDPQERATAQELLDHPFLLQTG-LPECLVPLIQLYRK 676
L ++P R TA+ELL H F+L+ L LI Y++
Sbjct: 267 LNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKR 305
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 194 bits (494), Expect = 2e-49
Identities = 112/273 (41%), Positives = 161/273 (58%), Gaps = 6/273 (2%)
Query: 402 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQH 461
DPR D ++G G+ G V AR+K SG VA+KM+ + L E++I++ +H
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
Query: 462 FNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ 520
N+V + SYL ++LW+ MEF G+L DI L+E QI+ VC VLQ LAYLH+Q
Sbjct: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 131
Query: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL--- 577
IHRDIK +IL+ G V+L+DFG AQI + +R S +GTPYWMAPEV + +L
Sbjct: 132 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGG 191
Query: 578 YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLKNSHKVSPVLRDFL 635
Y DIWSLGI IE+ + +PP F P++ + + S PP+LK K S +F+
Sbjct: 192 YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFI 251
Query: 636 ERMLVRDPQERATAQELLDHPFLLQTGLPECLV 668
+ L + P++R +A ++L H + Q GL L+
Sbjct: 252 KVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLI 284
Score = 32.7 bits (73), Expect = 1.1
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 18/81 (22%)
Query: 247 PSPKTRESSLKR--------RLFRSMFLSTAATAPPSSSKPGPPPQ-SKPN-------SS 290
P PK R S + +L + + A+ PP+S +PGPPP S P+ S
Sbjct: 399 PKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSL 458
Query: 291 FRPPQK--DNPPSLVAKAQSL 309
+ PP + D PP L K + +
Sbjct: 459 WNPPSRELDKPPLLPPKKEKM 479
Score = 31.6 bits (70), Expect = 2.5
Identities = 28/106 (26%), Positives = 40/106 (37%), Gaps = 8/106 (7%)
Query: 247 PSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKA 306
P R SS +++L S P+ ++ PPP P FR P + P S+
Sbjct: 360 PPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLP-PKPKFRSPSDEGPGSMGDDG 418
Query: 307 QSLP-------SDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGR 345
Q P S P + P TSSP + + P+ P R
Sbjct: 419 QLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSR 464
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 194 bits (494), Expect = 2e-49
Identities = 112/273 (41%), Positives = 161/273 (58%), Gaps = 6/273 (2%)
Query: 402 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQH 461
DPR D ++G G+ G V AR+K SG VA+KM+ + L E++I++ +H
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
Query: 462 FNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ 520
N+V + SYL ++LW+ MEF G+L DI L+E QI+ VC VLQ LAYLH+Q
Sbjct: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 131
Query: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL--- 577
IHRDIK +IL+ G V+L+DFG AQI + +R S +GTPYWMAPEV + +L
Sbjct: 132 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGG 191
Query: 578 YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLKNSHKVSPVLRDFL 635
Y DIWSLGI IE+ + +PP F P++ + + S PP+LK K S +F+
Sbjct: 192 YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFI 251
Query: 636 ERMLVRDPQERATAQELLDHPFLLQTGLPECLV 668
+ L + P++R +A ++L H + Q GL L+
Sbjct: 252 KVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLI 284
Score = 32.7 bits (73), Expect = 1.1
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 18/81 (22%)
Query: 247 PSPKTRESSLKR--------RLFRSMFLSTAATAPPSSSKPGPPPQ-SKPN-------SS 290
P PK R S + +L + + A+ PP+S +PGPPP S P+ S
Sbjct: 399 PKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSL 458
Query: 291 FRPPQK--DNPPSLVAKAQSL 309
+ PP + D PP L K + +
Sbjct: 459 WNPPSRELDKPPLLPPKKEKM 479
Score = 31.6 bits (70), Expect = 2.5
Identities = 28/106 (26%), Positives = 40/106 (37%), Gaps = 8/106 (7%)
Query: 247 PSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKA 306
P R SS +++L S P+ ++ PPP P FR P + P S+
Sbjct: 360 PPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLP-PKPKFRSPSDEGPGSMGDDG 418
Query: 307 QSLP-------SDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGR 345
Q P S P + P TSSP + + P+ P R
Sbjct: 419 QLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSR 464
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 194 bits (493), Expect = 2e-49
Identities = 114/282 (40%), Positives = 164/282 (58%), Gaps = 7/282 (2%)
Query: 393 ALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNE 452
AL V DPR + ++G G+ G V AR+ + AVK++ L L E
Sbjct: 2 ALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQE 61
Query: 453 VVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVCEAVL 511
+ I+R+ +H NVV SYL + LW+ MEF GG+L +I L E QIA VC L
Sbjct: 62 ITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREAL 121
Query: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
+ L +LH+QG IHRDIK ++LLTL G VKL+DFG +++ V KR+S +GTPYWMAPE
Sbjct: 122 KGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE 181
Query: 572 VIS---RSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLKNSHK 626
V + + Y D+W+LGI IE+ + +PP F P++A+ + S PPKL++ +
Sbjct: 182 VAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTR 241
Query: 627 VSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLV 668
+ FL+ L ++P++R TA++LL HPF Q LP L+
Sbjct: 242 WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALL 282
Score = 29.6 bits (65), Expect = 9.6
Identities = 18/45 (40%), Positives = 21/45 (46%), Gaps = 2/45 (4%)
Query: 248 SPKTRESSLKRRLFRSMFLSTAATAPPSSSKPG--PPPQSKPNSS 290
SP ++KR F + P SS PG PPP S PNSS
Sbjct: 394 SPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSS 438
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 193 bits (490), Expect = 5e-49
Identities = 107/280 (38%), Positives = 162/280 (57%), Gaps = 4/280 (1%)
Query: 402 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRDYQ 460
DP L +IG+GS G V + H+ VA+K++DL + + E + E+ ++
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 461 HFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQ 520
+ + SYL +LW++ME+L GG+ D++ L E IAT+ +L+ L YLH++
Sbjct: 75 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 134
Query: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT 580
IHRDIK+ ++LL+ G VKL+DFG Q++ KR + VGTP+WMAPEVI +S Y
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 194
Query: 581 EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLV 640
+ DIWSLGI IE+ GEPP P++ + + + PP L+ H S ++F+E L
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACLN 252
Query: 641 RDPQERATAQELLDHPFLLQ-TGLPECLVPLIQLYRKQTS 679
+DP+ R TA+ELL H F+ + T L LI Y++ S
Sbjct: 253 KDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKS 292
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,368,297
Number of Sequences: 37866
Number of extensions: 1793935
Number of successful extensions: 15666
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 788
Number of HSP's successfully gapped in prelim test: 887
Number of HSP's that attempted gapping in prelim test: 9597
Number of HSP's gapped (non-prelim): 4353
length of query: 681
length of database: 18,247,518
effective HSP length: 109
effective length of query: 572
effective length of database: 14,120,124
effective search space: 8076710928
effective search space used: 8076710928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.