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Search of human proteins with 89276769
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens]
(587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens] 1192 0.0
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 582 e-166
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 265 7e-71
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 265 9e-71
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 265 9e-71
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 250 2e-66
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 242 8e-64
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 217 3e-56
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 217 3e-56
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 217 3e-56
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 206 4e-53
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 206 6e-53
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 198 1e-50
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 197 2e-50
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 197 3e-50
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 196 7e-50
gi|149408126 nemo like kinase [Homo sapiens] 184 2e-46
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 174 3e-43
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 172 8e-43
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 172 1e-42
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 166 6e-41
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 166 6e-41
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 164 3e-40
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 164 3e-40
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 161 2e-39
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 161 2e-39
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 160 2e-39
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 160 2e-39
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 160 2e-39
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 160 2e-39
>gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens]
Length = 587
Score = 1192 bits (3084), Expect = 0.0
Identities = 587/587 (100%), Positives = 587/587 (100%)
Query: 1 MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK 60
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK
Sbjct: 1 MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK 60
Query: 61 HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT 120
HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT
Sbjct: 61 HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT 120
Query: 121 LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS 180
LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS
Sbjct: 121 LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS 180
Query: 181 HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL 240
HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL
Sbjct: 181 HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL 240
Query: 241 ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR 300
ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR
Sbjct: 241 ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR 300
Query: 301 LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS 360
LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS
Sbjct: 301 LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS 360
Query: 361 LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF 420
LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF
Sbjct: 361 LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF 420
Query: 421 EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG 480
EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG
Sbjct: 421 EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG 480
Query: 481 AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD 540
AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD
Sbjct: 481 AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD 540
Query: 541 VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW 587
VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
Sbjct: 541 VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW 587
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 582 bits (1500), Expect = e-166
Identities = 323/589 (54%), Positives = 398/589 (67%), Gaps = 55/589 (9%)
Query: 1 MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK 60
MAEK + + +++G+DLG R++D +PLG G NGLV SAVD+ ++VA+KKI L+D +S+K
Sbjct: 1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK 60
Query: 61 HALREIKIIRRLDHDNIVKVYEVLGPKG---TDLQGELFKFSVAYIVQEYMETDLARLLE 117
HALREIKIIRRLDHDNIVKV+E+LGP G TD G L + + YIVQEYMETDLA +LE
Sbjct: 61 HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE 120
Query: 118 QGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQ 177
QG L EEHA+LFMYQLLRGLKYIHSANVLHRDLKPAN+FI+TEDLVLKIGDFGLARI+D
Sbjct: 121 QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 180
Query: 178 HYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQ 237
HYSHKG+LSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI AEMLTG+ LFAGAHELEQ
Sbjct: 181 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 240
Query: 238 MQLILETIPVIREEDKDELLRVMPSFV-SSTWEVKRPLRKLLPEVNSEAIDFLEKILTFN 296
MQLILE+IPV+ EED+ ELL V+P ++ + E +PL +LLP ++ EA+DFLE+ILTF+
Sbjct: 241 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS 300
Query: 297 PMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSR 356
PMDRLTAE L HPYMS YS P DEP S HPF IEDE+DDI+LM S + NW+ R
Sbjct: 301 PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWE----R 356
Query: 357 YPVSLSSDLEWRPDRCQDASEVQRDPRA-GSAPLAEDVQVDPRKDSHSSSERFLEQ---- 411
Y S+ +W D EVQ DPRA E+VQVDPRK E++LE
Sbjct: 357 YHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFD 416
Query: 412 -----------SHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDL 460
S + + + +C+YK S SYLD L+WR+++ +HY EPKLI+DL
Sbjct: 417 TNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDL 476
Query: 461 SHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSA 520
S+WK+ + + D+ E VK+ Q E AS ER +
Sbjct: 477 SNWKE------------QSKEKSDKKGKSKCERNGLVKA-QIALEEASQQLAGKEREKNQ 523
Query: 521 SPPGRPAPVDGGASPQFDLDVFISRALKLCT--KPEDLPDNKLGDLNGA 567
FD D FI+ ++L + +P D+ D KL DLN +
Sbjct: 524 G---------------FDFDSFIAGTIQLSSQHEPTDVVD-KLNDLNSS 556
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 265 bits (678), Expect = 7e-71
Identities = 141/333 (42%), Positives = 208/333 (62%), Gaps = 22/333 (6%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
+D+G R+ Q +G G G+V SA D +VA+KKI+ + ++ + LREI+I+ R
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
H+N++ + ++L + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 96 RHENVIGIRDILRASTLEAMRDV------YIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149
Query: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
+LRGLKYIHSANVLHRDLKP+N+ I+T LKI DFGLARI D + H G+L+E + T+
Sbjct: 150 ILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Query: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL + +ED
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
Query: 253 KD--------ELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAE 304
+ L+ +PS W KL P+ +S+A+D L+++LTFNP R+T E
Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAW------AKLFPKSDSKALDLLDRMLTFNPNKRITVE 322
Query: 305 MGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDI 337
L HPY+ Y P DEP ++ PF E+DD+
Sbjct: 323 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDL 355
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 265 bits (677), Expect = 9e-71
Identities = 138/327 (42%), Positives = 211/327 (64%), Gaps = 10/327 (3%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
+D+G R+ + +G G G+V SA D+ +VA+KKI+ + ++ + LREIKI+ R
Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 78
Query: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
H+NI+ + +++ + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 79 RHENIIGINDIIRAPTIEQMKDV------YIVQDLMETDLYKLLKTQHLSNDHICYFLYQ 132
Query: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
+LRGLKYIHSANVLHRDLKP+N+ ++T LKI DFGLAR+ D + H G+L+E + T+
Sbjct: 133 ILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL + +ED
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 253 KDEL--LRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHP 310
+ + L+ +S + K P +L P +S+A+D L+K+LTFNP R+ E L HP
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Query: 311 YMSPYSCPEDEPTSQHPFRIEDEIDDI 337
Y+ Y P DEP ++ PF+ + E+DD+
Sbjct: 312 YLEQYYDPSDEPIAEAPFKFDMELDDL 338
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 265 bits (677), Expect = 9e-71
Identities = 138/327 (42%), Positives = 211/327 (64%), Gaps = 10/327 (3%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
+D+G R+ + +G G G+V SA D+ +VA+KKI+ + ++ + LREIKI+ R
Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 78
Query: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
H+NI+ + +++ + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 79 RHENIIGINDIIRAPTIEQMKDV------YIVQDLMETDLYKLLKTQHLSNDHICYFLYQ 132
Query: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
+LRGLKYIHSANVLHRDLKP+N+ ++T LKI DFGLAR+ D + H G+L+E + T+
Sbjct: 133 ILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL + +ED
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 253 KDEL--LRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHP 310
+ + L+ +S + K P +L P +S+A+D L+K+LTFNP R+ E L HP
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Query: 311 YMSPYSCPEDEPTSQHPFRIEDEIDDI 337
Y+ Y P DEP ++ PF+ + E+DD+
Sbjct: 312 YLEQYYDPSDEPIAEAPFKFDMELDDL 338
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 250 bits (639), Expect = 2e-66
Identities = 135/317 (42%), Positives = 198/317 (62%), Gaps = 22/317 (6%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
+D+G R+ Q +G G G+V SA D +VA+KKI+ + ++ + LREI+I+ R
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
H+N++ + ++L + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 96 RHENVIGIRDILRASTLEAMRDV------YIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149
Query: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
+LRGLKYIHSANVLHRDLKP+N+ I+T LKI DFGLARI D + H G+L+E + T+
Sbjct: 150 ILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Query: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL + +ED
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
Query: 253 KD--------ELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAE 304
+ L+ +PS W KL P+ +S+A+D L+++LTFNP R+T E
Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAW------AKLFPKSDSKALDLLDRMLTFNPNKRITVE 322
Query: 305 MGLQHPYMSPYSCPEDE 321
L HPY+ Y P DE
Sbjct: 323 EALAHPYLEQYYDPTDE 339
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 242 bits (617), Expect = 8e-64
Identities = 131/325 (40%), Positives = 190/325 (58%), Gaps = 50/325 (15%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
+D+G R+ Q +G G G+V SA D +VA+KKI+ + ++ + LREI+I+ R
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
H+N++ + ++L + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 96 RHENVIGIRDILRASTLEAMRDV------YIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149
Query: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
+LRGLKYIHSANVLHRDLKP+N+ I+T LKI DFGLARI D + H G+L+E + T+
Sbjct: 150 ILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Query: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---------- 258
Query: 253 KDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM 312
A+D L+++LTFNP R+T E L HPY+
Sbjct: 259 --------------------------------ALDLLDRMLTFNPNKRITVEEALAHPYL 286
Query: 313 SPYSCPEDEPTSQHPFRIEDEIDDI 337
Y P DEP ++ PF E+DD+
Sbjct: 287 EQYYDPTDEPVAEEPFTFAMELDDL 311
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 217 bits (552), Expect = 3e-56
Identities = 123/323 (38%), Positives = 191/323 (59%), Gaps = 16/323 (4%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRR 71
+D+G + + +G G G+V SA ++VA+KKI A + K LRE+KI++
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT-LAEEHAKLFM 130
HDNI+ + ++L P T GE F Y+V + ME+DL +++ L EH + F+
Sbjct: 109 FKHDNIIAIKDILRP--TVPYGE---FKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFL 163
Query: 131 YQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLAR-IVDQHYSHKGYLSEGL 189
YQLLRGLKY+HSA V+HRDLKP+N+ ++ E+ LKIGDFG+AR + H+ +++E +
Sbjct: 164 YQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYV 222
Query: 190 VTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI---- 245
T+WYR+P L+LS + YT+AID+W+ GCI EML R LF G + + Q+QLI+ +
Sbjct: 223 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
Query: 246 PVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEM 305
P + + E +R + V P + P + +A+ L ++L F P R++A
Sbjct: 283 PAVIQAVGAERVRAYIQSLPPRQPV--PWETVYPGADRQALSLLGRMLRFEPSARISAAA 340
Query: 306 GLQHPYMSPYSCPEDEPTSQHPF 328
L+HP+++ Y P+DEP PF
Sbjct: 341 ALRHPFLAKYHDPDDEPDCAPPF 363
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 217 bits (552), Expect = 3e-56
Identities = 123/323 (38%), Positives = 191/323 (59%), Gaps = 16/323 (4%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRR 71
+D+G + + +G G G+V SA ++VA+KKI A + K LRE+KI++
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT-LAEEHAKLFM 130
HDNI+ + ++L P T GE F Y+V + ME+DL +++ L EH + F+
Sbjct: 109 FKHDNIIAIKDILRP--TVPYGE---FKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFL 163
Query: 131 YQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLAR-IVDQHYSHKGYLSEGL 189
YQLLRGLKY+HSA V+HRDLKP+N+ ++ E+ LKIGDFG+AR + H+ +++E +
Sbjct: 164 YQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYV 222
Query: 190 VTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI---- 245
T+WYR+P L+LS + YT+AID+W+ GCI EML R LF G + + Q+QLI+ +
Sbjct: 223 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
Query: 246 PVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEM 305
P + + E +R + V P + P + +A+ L ++L F P R++A
Sbjct: 283 PAVIQAVGAERVRAYIQSLPPRQPV--PWETVYPGADRQALSLLGRMLRFEPSARISAAA 340
Query: 306 GLQHPYMSPYSCPEDEPTSQHPF 328
L+HP+++ Y P+DEP PF
Sbjct: 341 ALRHPFLAKYHDPDDEPDCAPPF 363
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 217 bits (552), Expect = 3e-56
Identities = 123/323 (38%), Positives = 191/323 (59%), Gaps = 16/323 (4%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRR 71
+D+G + + +G G G+V SA ++VA+KKI A + K LRE+KI++
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT-LAEEHAKLFM 130
HDNI+ + ++L P T GE F Y+V + ME+DL +++ L EH + F+
Sbjct: 109 FKHDNIIAIKDILRP--TVPYGE---FKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFL 163
Query: 131 YQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLAR-IVDQHYSHKGYLSEGL 189
YQLLRGLKY+HSA V+HRDLKP+N+ ++ E+ LKIGDFG+AR + H+ +++E +
Sbjct: 164 YQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYV 222
Query: 190 VTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI---- 245
T+WYR+P L+LS + YT+AID+W+ GCI EML R LF G + + Q+QLI+ +
Sbjct: 223 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
Query: 246 PVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEM 305
P + + E +R + V P + P + +A+ L ++L F P R++A
Sbjct: 283 PAVIQAVGAERVRAYIQSLPPRQPV--PWETVYPGADRQALSLLGRMLRFEPSARISAAA 340
Query: 306 GLQHPYMSPYSCPEDEPTSQHPF 328
L+HP+++ Y P+DEP PF
Sbjct: 341 ALRHPFLAKYHDPDDEPDCAPPF 363
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 206 bits (525), Expect = 4e-53
Identities = 116/326 (35%), Positives = 186/326 (57%), Gaps = 31/326 (9%)
Query: 22 DFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRRLDHDNIVK 79
D QP+G G G V SAVD R KVA+KK+ K A RE+++++ + H+N++
Sbjct: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88
Query: 80 VYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKY 139
+ +V P T L F+ Y+V +M TDL +L++ L E+ + +YQ+L+GL+Y
Sbjct: 89 LLDVFTPDET-----LDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143
Query: 140 IHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRL 199
IH+A ++HRDLKP N+ ++ ED LKI DFGLAR D + GY+ VT+WYR+P +
Sbjct: 144 IHAAGIIHRDLKPGNLAVN-EDCELKILDFGLARQADSEMT--GYV----VTRWYRAPEV 196
Query: 200 LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLIL--------ETIPVIREE 251
+L+ YT+ +D+W+ GCI+AEM+TG+ LF G+ L+Q++ I+ E + ++ +
Sbjct: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256
Query: 252 DKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPY 311
+ ++ +P K+ +L + A++ LEK+L + R+TA L HPY
Sbjct: 257 EAKNYMKGLPEL------EKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310
Query: 312 MSPYSCPEDEPTSQHPFRIEDEIDDI 337
EDEP Q + +D DD+
Sbjct: 311 FESLHDTEDEPQVQ---KYDDSFDDV 333
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 206 bits (523), Expect = 6e-53
Identities = 120/319 (37%), Positives = 188/319 (58%), Gaps = 17/319 (5%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM--KHALREIKIIRR 71
++L +V +G G G V SA+D R+ KVA+KK++ + K A RE+ +++
Sbjct: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY 131
+ H+N++ + +V P + L F Y+V +M+TDL +++ +EE + +Y
Sbjct: 79 MQHENVIGLLDVFTPASS-----LRNFYDFYLVMPFMQTDLQKIMGM-EFSEEKIQYLVY 132
Query: 132 QLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVT 191
Q+L+GLKYIHSA V+HRDLKP N+ ++ ED LKI DFGLAR D + GY+ VT
Sbjct: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLARHADAEMT--GYV----VT 185
Query: 192 KWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREE 251
+WYR+P ++LS +Y + +D+W+ GCI+AEMLTG+ LF G L+Q+ IL+ V E
Sbjct: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245
Query: 252 DKDELL-RVMPSFVSSTWEV-KRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQH 309
+L + S++ S + ++ +L P + +A D LEK+L + RLTA L H
Sbjct: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305
Query: 310 PYMSPYSCPEDEPTSQHPF 328
P+ P+ PE+E +Q PF
Sbjct: 306 PFFEPFRDPEEETEAQQPF 324
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 198 bits (504), Expect = 1e-50
Identities = 115/334 (34%), Positives = 191/334 (57%), Gaps = 25/334 (7%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRR 71
+++ R+ + P+G G G V +A D++ +VAVKK++ K RE+++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY 131
+ H+N++ + +V P + L +F+ Y+V M DL +++ L ++H + +Y
Sbjct: 78 MKHENVIGLLDVFTPARS-----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132
Query: 132 QLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVT 191
Q+LRGLKYIHSA+++HRDLKP+N+ ++ ED LKI DFGLAR D + GY++ T
Sbjct: 133 QILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEMT--GYVA----T 185
Query: 192 KWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREE 251
+WYR+P ++L+ +Y + +D+W+ GCI+AE+LTGR LF G ++Q++LIL +
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT---- 241
Query: 252 DKDELLRVMPS------FVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEM 305
ELL+ + S S T K + N A+D LEK+L + R+TA
Sbjct: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301
Query: 306 GLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVL 339
L H Y + Y P+DEP + P+ E D+++
Sbjct: 302 ALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLI 334
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 197 bits (501), Expect = 2e-50
Identities = 118/317 (37%), Positives = 176/317 (55%), Gaps = 29/317 (9%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRRL-DHD 75
R++ + LG G G+V AVD R VA+KKI A D + REI +++ DH
Sbjct: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
Query: 76 NIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEE-HAKLFMYQLL 134
NI+ + +V+ + Y+V E+M+TDL ++ +G L ++ H + YQLL
Sbjct: 72 NIISLLDVIRAEND---------RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLL 122
Query: 135 RGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQ--HYSHKGYLSEGLVTK 192
R +++HS +V+HRD KP+N+ + + +K+ DFGLAR + ++E + T+
Sbjct: 123 RATRFLHSGHVVHRDQKPSNVLLDA-NCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATR 181
Query: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
WYR+P +LLS + YT +DMW+ GCIL EML GR LF G L Q++LILETIP EED
Sbjct: 182 WYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEED 241
Query: 253 --------KDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAE 304
+ +L + S T + P P+ + EA+D L ++L F P RL+A
Sbjct: 242 LLALGSGCRASVLHQLGSRPRQTLDALLP-----PDTSPEALDLLRRLLVFAPDKRLSAT 296
Query: 305 MGLQHPYMSPYSCPEDE 321
LQHPY+ + CP DE
Sbjct: 297 QALQHPYVQRFHCPSDE 313
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 197 bits (500), Expect = 3e-50
Identities = 115/320 (35%), Positives = 193/320 (60%), Gaps = 24/320 (7%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHA---LREIKIIR 70
+++ R +P+G G G V SA D+R +KVAVKK++ +S+ HA RE+++++
Sbjct: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLK 76
Query: 71 RLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFM 130
L H+N++ + +V P T ++ FS Y+V M DL +++ L++EH + +
Sbjct: 77 HLKHENVIGLLDVFTP-ATSIED----FSEVYLVTTLMGADLNNIVKCQALSDEHVQFLV 131
Query: 131 YQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLV 190
YQLLRGLKYIHSA ++HRDLKP+N+ ++ ED L+I DFGLAR D+ + GY++
Sbjct: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLARQADEEMT--GYVA---- 184
Query: 191 TKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI----P 246
T+WYR+P ++L+ +Y + +D+W+ GCI+AE+L G+ LF G+ ++Q++ I+E + P
Sbjct: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244
Query: 247 VIREEDKDELLRVMPSFVSSTWEV-KRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEM 305
+ + E R +++ S + ++ L + N AID L ++L + R++A
Sbjct: 245 EVLAKISSEHAR---TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301
Query: 306 GLQHPYMSPYSCPEDEPTSQ 325
L H Y S Y PEDEP ++
Sbjct: 302 ALAHAYFSQYHDPEDEPEAE 321
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 196 bits (497), Expect = 7e-50
Identities = 114/334 (34%), Positives = 188/334 (56%), Gaps = 25/334 (7%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRR 71
+++ R+ + P+G G G V +A D++ +VAVKK++ K RE+++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY 131
+ H+N++ + +V P + L +F+ Y+V M DL +++ L ++H + +Y
Sbjct: 78 MKHENVIGLLDVFTPARS-----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132
Query: 132 QLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVT 191
Q+LRGLKYIHSA+++HRDLKP+N+ ++ ED LKI DFGLAR D + GY++ T
Sbjct: 133 QILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEMT--GYVA----T 185
Query: 192 KWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREE 251
+WYR+P ++L+ +Y + +D+W+ GCI+AE+LTGR LF G + Q+Q I+ +
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR----LTGT 241
Query: 252 DKDELLRVMPS------FVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEM 305
L+ MPS S T K + N A+D LEK+L + R+TA
Sbjct: 242 PPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301
Query: 306 GLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVL 339
L H Y + Y P+DEP + P+ E D+++
Sbjct: 302 ALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLI 334
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 184 bits (467), Expect = 2e-46
Identities = 107/303 (35%), Positives = 174/303 (57%), Gaps = 31/303 (10%)
Query: 24 QPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRRLDHDNIVKVY 81
+P+G+G G+V S D R ++VA+KK+ + S K RE+K++ HDN++
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 82 EVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLL-EQGTLAEEHAKLFMYQLLRGLKYI 140
++L P D F Y+V E M++DL +++ L+ +H K+F+YQ+LRGLKY+
Sbjct: 202 DILQPPHIDY------FEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYL 255
Query: 141 HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLL 200
HSA +LHRD+KP N+ +++ + VLKI DFGLAR+ + ++++ +VT++YR+P +L
Sbjct: 256 HSAGILHRDIKPGNLLVNS-NCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEIL 312
Query: 201 LSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLI--------LETIPVIREED 252
+ +Y+ AID+W+ GCI AE+L R+LF ++Q+ LI LE + E
Sbjct: 313 MGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGA 372
Query: 253 KDELLR---VMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQH 309
K +LR PS L L + EA+ L ++L F+P R++A+ L H
Sbjct: 373 KAHILRGPHKQPSL--------PVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAH 424
Query: 310 PYM 312
PY+
Sbjct: 425 PYL 427
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 174 bits (440), Expect = 3e-43
Identities = 99/299 (33%), Positives = 175/299 (58%), Gaps = 29/299 (9%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRR 71
+++ R+ + P+G G G V +A D++ +VAVKK++ K RE+++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY 131
+ H+N++ + +V P + L +F+ Y+V M DL +++ L ++H + +Y
Sbjct: 78 MKHENVIGLLDVFTPARS-----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132
Query: 132 QLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVT 191
Q+LRGLKYIHSA+++HRDLKP+N+ ++ ED LKI DFGLAR D + GY++ T
Sbjct: 133 QILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEMT--GYVA----T 185
Query: 192 KWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREE 251
+WYR+P ++L+ +Y + +D+W+ GCI+AE+LTGR LF G ++Q++LIL ++
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR---LVGTP 242
Query: 252 DKDELLRVMPSFVSSTW----------EVKRPLRKLLPEVNSEAIDFLEK--ILTFNPM 298
+ L ++ +S+ W E++RP +P + S I + + IL +P+
Sbjct: 243 GAELLKKISSESLSTCWRRCLYWTQIRELQRPKPLHMPTLLSTTILMMNQWPILMISPL 301
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 172 bits (436), Expect = 8e-43
Identities = 91/227 (40%), Positives = 140/227 (61%), Gaps = 9/227 (3%)
Query: 108 METDLARLLEQGT-LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKI 166
ME+DL +++ L EH + F+YQLLRGLKY+HSA V+HRDLKP+N+ ++ E+ LKI
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKI 59
Query: 167 GDFGLAR-IVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTG 225
GDFG+AR + H+ +++E + T+WYR+P L+LS + YT+AID+W+ GCI EML
Sbjct: 60 GDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLAR 119
Query: 226 RMLFAGAHELEQMQLILETI----PVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEV 281
R LF G + + Q+QLI+ + P + + E +R + V P + P
Sbjct: 120 RQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPV--PWETVYPGA 177
Query: 282 NSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPF 328
+ +A+ L ++L F P R++A L+HP+++ Y P+DEP PF
Sbjct: 178 DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPF 224
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 172 bits (435), Expect = 1e-42
Identities = 87/234 (37%), Positives = 149/234 (63%), Gaps = 14/234 (5%)
Query: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRR 71
+++ R+ + P+G G G V +A D++ +VAVKK++ K RE+++++
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 72 LDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY 131
+ H+N++ + +V P + L +F+ Y+V M DL +++ L ++H + +Y
Sbjct: 78 MKHENVIGLLDVFTPARS-----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132
Query: 132 QLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVT 191
Q+LRGLKYIHSA+++HRDLKP+N+ ++ ED LKI DFGLAR D + GY++ T
Sbjct: 133 QILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEMT--GYVA----T 185
Query: 192 KWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI 245
+WYR+P ++L+ +Y + +D+W+ GCI+AE+LTGR LF G ++Q++LIL +
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 166 bits (420), Expect = 6e-41
Identities = 114/310 (36%), Positives = 169/310 (54%), Gaps = 19/310 (6%)
Query: 15 DLGGRFVD----FQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARS--MKHALREIKI 68
D G R VD +G G G V A D VA+KK+ L + + A+REIKI
Sbjct: 718 DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 777
Query: 69 IRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTL--AEEHA 126
+R+L H ++V + E++ K L + K Y+V EYM+ DL LLE G + +E+H
Sbjct: 778 LRQLIHRSVVNMKEIVTDKQDALDFKKDK-GAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836
Query: 127 KLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLS 186
K FM QL+ GL+Y H N LHRD+K +NI ++ + K+ DFGLAR+ + S +
Sbjct: 837 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQI-KLADFGLARLYNSEESRP--YT 893
Query: 187 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIP 246
++T WYR P LLL YT AID+W+ GCIL E+ T + +F EL Q++LI
Sbjct: 894 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCG 953
Query: 247 VIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPE----VNSEAIDFLEKILTFNPMDRLT 302
++++ +P F +T + K+ R+ L E + S A+D L+ +LT +P R T
Sbjct: 954 SPCPAVWPDVIK-LPYF--NTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCT 1010
Query: 303 AEMGLQHPYM 312
AE LQ ++
Sbjct: 1011 AEQTLQSDFL 1020
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 166 bits (420), Expect = 6e-41
Identities = 114/310 (36%), Positives = 169/310 (54%), Gaps = 19/310 (6%)
Query: 15 DLGGRFVD----FQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARS--MKHALREIKI 68
D G R VD +G G G V A D VA+KK+ L + + A+REIKI
Sbjct: 718 DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 777
Query: 69 IRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTL--AEEHA 126
+R+L H ++V + E++ K L + K Y+V EYM+ DL LLE G + +E+H
Sbjct: 778 LRQLIHRSVVNMKEIVTDKQDALDFKKDK-GAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836
Query: 127 KLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLS 186
K FM QL+ GL+Y H N LHRD+K +NI ++ + K+ DFGLAR+ + S +
Sbjct: 837 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQI-KLADFGLARLYNSEESRP--YT 893
Query: 187 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIP 246
++T WYR P LLL YT AID+W+ GCIL E+ T + +F EL Q++LI
Sbjct: 894 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCG 953
Query: 247 VIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPE----VNSEAIDFLEKILTFNPMDRLT 302
++++ +P F +T + K+ R+ L E + S A+D L+ +LT +P R T
Sbjct: 954 SPCPAVWPDVIK-LPYF--NTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCT 1010
Query: 303 AEMGLQHPYM 312
AE LQ ++
Sbjct: 1011 AEQTLQSDFL 1020
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 164 bits (414), Expect = 3e-40
Identities = 100/317 (31%), Positives = 172/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P Q L +F YIV E M+ +L ++++ L E +YQ+L G
Sbjct: 85 IIGLLNVFTP-----QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 193
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ G +LF G ++Q ++E + E +L
Sbjct: 194 PEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 252
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPEV------------NSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+V S+A D L K+L + R++
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 313 DEALQHPYINVWYDPSE 329
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 164 bits (414), Expect = 3e-40
Identities = 100/317 (31%), Positives = 172/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P Q L +F YIV E M+ +L ++++ L E +YQ+L G
Sbjct: 85 IIGLLNVFTP-----QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 193
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ G +LF G ++Q ++E + E +L
Sbjct: 194 PEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 252
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPEV------------NSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+V S+A D L K+L + R++
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 313 DEALQHPYINVWYDPSE 329
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 161 bits (407), Expect = 2e-39
Identities = 99/317 (31%), Positives = 172/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P Q L +F YIV E M+ +L ++++ L E +YQ+L G
Sbjct: 85 IIGLLNVFTP-----QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 193
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ ++LF G ++Q ++E + E +L
Sbjct: 194 PEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPEV------------NSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+V S+A D L K+L + R++
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 313 DEALQHPYINVWYDPSE 329
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 161 bits (407), Expect = 2e-39
Identities = 99/317 (31%), Positives = 172/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P Q L +F YIV E M+ +L ++++ L E +YQ+L G
Sbjct: 85 IIGLLNVFTP-----QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 193
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ ++LF G ++Q ++E + E +L
Sbjct: 194 PEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPEV------------NSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+V S+A D L K+L + R++
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 313 DEALQHPYINVWYDPSE 329
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 160 bits (406), Expect = 2e-39
Identities = 98/317 (30%), Positives = 173/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P+ T L +F Y+V E M+ +L ++++ L E +YQ+L G
Sbjct: 123 IISLLNVFTPQKT-----LEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 176
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 231
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ ++LF G ++Q ++E + E +L
Sbjct: 232 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPE------------VNSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+ S+A D L K+L +P R++
Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 351 DDALQHPYINVWYDPAE 367
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 160 bits (406), Expect = 2e-39
Identities = 98/317 (30%), Positives = 173/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P+ T L +F Y+V E M+ +L ++++ L E +YQ+L G
Sbjct: 123 IISLLNVFTPQKT-----LEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 176
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 231
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ ++LF G ++Q ++E + E +L
Sbjct: 232 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPE------------VNSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+ S+A D L K+L +P R++
Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 351 DDALQHPYINVWYDPAE 367
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 160 bits (406), Expect = 2e-39
Identities = 98/317 (30%), Positives = 173/317 (54%), Gaps = 27/317 (8%)
Query: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDN 76
R+ + +P+G G G+V +A D+ R VA+KK++ + K A RE+ +++ ++H N
Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84
Query: 77 IVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRG 136
I+ + V P+ T L +F Y+V E M+ +L ++++ L E +YQ+L G
Sbjct: 85 IISLLNVFTPQKT-----LEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRS 196
+K++HSA ++HRDLKP+NI + + D LKI DFGLAR + Y +VT++YR+
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY----VVTRYYRA 193
Query: 197 PRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
P ++L Y + +D+W+ GCI+ EM+ ++LF G ++Q ++E + E +L
Sbjct: 194 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252
Query: 257 LRVMPSFVSSTWE-VKRPLRKLLPE------------VNSEAIDFLEKILTFNPMDRLTA 303
+ ++V + + KL P+ S+A D L K+L +P R++
Sbjct: 253 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312
Query: 304 EMGLQHPYMSPYSCPED 320
+ LQHPY++ + P +
Sbjct: 313 DDALQHPYINVWYDPAE 329
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 160 bits (406), Expect = 2e-39
Identities = 111/310 (35%), Positives = 163/310 (52%), Gaps = 19/310 (6%)
Query: 15 DLGGRFVD----FQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARS--MKHALREIKI 68
D G R VD +G G G V A D VA+KK+ L + + A+REIKI
Sbjct: 696 DWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI 755
Query: 69 IRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLA--EEHA 126
+R+L H +I+ + E++ K L + K Y+V EYM+ DL LLE G + E H
Sbjct: 756 LRQLTHQSIINMKEIVTDKEDALDFKKDK-GAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
Query: 127 KLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLS 186
K FM QL+ GL Y H N LHRD+K +NI ++ + K+ DFGLAR+ S +
Sbjct: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQI-KLADFGLARLYSSEESRP--YT 871
Query: 187 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIP 246
++T WYR P LLL YT AID+W+ GCIL E+ T + +F EL Q++LI
Sbjct: 872 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICG 931
Query: 247 VIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPE----VNSEAIDFLEKILTFNPMDRLT 302
++++ +P F +T + K+ R+ L E + + A+D + +L +P R T
Sbjct: 932 SPCPAVWPDVIK-LPYF--NTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCT 988
Query: 303 AEMGLQHPYM 312
AE LQ ++
Sbjct: 989 AEQALQCEFL 998
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,065,796
Number of Sequences: 37866
Number of extensions: 1178708
Number of successful extensions: 6359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 581
Number of HSP's successfully gapped in prelim test: 247
Number of HSP's that attempted gapping in prelim test: 4218
Number of HSP's gapped (non-prelim): 1153
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.