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Search of human proteins with 8922640
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8922640 kelch domain containing 8A [Homo sapiens]
(350 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8922640 kelch domain containing 8A [Homo sapiens] 717 0.0
gi|27734909 kelch domain containing 8B [Homo sapiens] 338 6e-93
gi|34101268 kelch-like 8 [Homo sapiens] 112 6e-25
gi|11056006 kelch-like 12 [Homo sapiens] 106 4e-23
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 103 2e-22
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 101 1e-21
gi|14780904 kelch-like 1 protein [Homo sapiens] 100 3e-21
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 97 2e-20
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 97 2e-20
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 97 2e-20
gi|40807500 kelch-like 20 [Homo sapiens] 96 4e-20
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 94 2e-19
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 92 5e-19
gi|223890235 intracisternal A particle-promoted polypeptide isof... 92 9e-19
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 91 1e-18
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 91 1e-18
gi|55925604 kelch-like 18 [Homo sapiens] 91 2e-18
gi|38194229 kelch-like 17 [Homo sapiens] 90 3e-18
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 88 1e-17
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 88 1e-17
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 88 1e-17
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 87 2e-17
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 87 2e-17
gi|148664209 kelch-like 10 [Homo sapiens] 87 2e-17
gi|166235129 kelch-like 3 [Homo sapiens] 87 3e-17
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 86 5e-17
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 86 6e-17
gi|31542246 kelch-like 36 [Homo sapiens] 85 1e-16
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 83 3e-16
gi|23397572 kelch-like 34 [Homo sapiens] 80 3e-15
>gi|8922640 kelch domain containing 8A [Homo sapiens]
Length = 350
Score = 717 bits (1852), Expect = 0.0
Identities = 350/350 (100%), Positives = 350/350 (100%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT
Sbjct: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI
Sbjct: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
Query: 121 SVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVL 180
SVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVL
Sbjct: 121 SVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVL 180
Query: 181 GGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPK 240
GGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPK
Sbjct: 181 GGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPK 240
Query: 241 FLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFH 300
FLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFH
Sbjct: 241 FLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFH 300
Query: 301 PGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVEALCVSDS 350
PGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVEALCVSDS
Sbjct: 301 PGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVEALCVSDS 350
>gi|27734909 kelch domain containing 8B [Homo sapiens]
Length = 354
Score = 338 bits (866), Expect = 6e-93
Identities = 160/344 (46%), Positives = 224/344 (65%), Gaps = 3/344 (0%)
Query: 9 FQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTA 68
F W+ P+P+ RVY ++ G + +GGC G+P+D E + W AL LPTA
Sbjct: 9 FAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTA 68
Query: 69 RAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYR 128
RAG A LGK+++V+GGV Q P+ VE + +DEG+W++R+ L +AAMG++ +D
Sbjct: 69 RAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGM 128
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
VYA GGMG D P ++ Y+ +D W+SL MPTP Y A++FL G+KIYVLGGRQ K
Sbjct: 129 VYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLP 188
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQ---GRLYRQPKFLRTM 245
V AFE FD+E R+WT+ P++P +RAF+ + ++SLGGL+Q Y +P F+ T+
Sbjct: 189 VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTV 248
Query: 246 DVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNK 305
++FD+E G W K+ RS ++ +RADFV GSL G ++ GGLGNQP L + E+F + +
Sbjct: 249 EMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRR 308
Query: 306 WEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVEALCVSD 349
WE LPAMPT RC+CSS+ L +GGV QG S AVEALC+ D
Sbjct: 309 WEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRD 352
Score = 98.2 bits (243), Expect = 1e-20
Identities = 77/302 (25%), Positives = 123/302 (40%), Gaps = 21/302 (6%)
Query: 2 EVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTA 61
E ++ W LAPLP+ R + + G QV +GG D+ P+ E + + +W
Sbjct: 50 ETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWER 109
Query: 62 LPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGIS 121
LP A GVA + +GG+G + P V +Y W + G S
Sbjct: 110 RATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGAS 169
Query: 122 VTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLG 181
++Y GG L P + +D+ W +P+ R A + ++ LG
Sbjct: 170 TFLHGNKIYVLGGRQGKL-PVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLG 228
Query: 182 GRQS---------KYAVNAFEVFDIETRSWTKFP---NIPYKRAFSSFVTLDNHLYSLGG 229
G Q + VN E+FD+E SWTK P + KRA +L H+ ++GG
Sbjct: 229 GLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGG 288
Query: 230 LRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQ 289
L QP L +++ F + + W + + + AG R+ V GG+
Sbjct: 289 LG-----NQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGP---RLFVIGGVAQG 340
Query: 290 PT 291
P+
Sbjct: 341 PS 342
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 112 bits (279), Expect = 6e-25
Identities = 80/318 (25%), Positives = 146/318 (45%), Gaps = 14/318 (4%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G ++ +GG +G P E YS + W P + + R V V ++ ++ +GG
Sbjct: 316 TAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHD 375
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
N+ L +EM++ KW ++ + GI++ + +YA GG+ D N ++ Y
Sbjct: 376 GNE-HLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD-DNTCFNDVERY 433
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D+ D W ++APM TPR S + +Y +GG ++++ E +D W + +
Sbjct: 434 DIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEM 493
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+RA + L LY +GG + L +++ +D W + L R
Sbjct: 494 GQRRAGNGVSKLHGCLYVVGG------FDDNSPLSSVERYDPRSNKW---DYVAALTTPR 544
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCL 328
++ G++ GG N L T EAF P N+WE++ ++ R A + + V +CL
Sbjct: 545 GGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVGSVSHCR-AGAGVAVCSCL 602
Query: 329 LA-VGGVNQGLSDAVEAL 345
+ + V G ++ V+ +
Sbjct: 603 TSQIRDVGHGSNNVVDCM 620
Score = 89.7 bits (221), Expect = 3e-18
Identities = 61/207 (29%), Positives = 91/207 (43%), Gaps = 9/207 (4%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCF---EVYSPEADQWTALPRLP 66
+W A + ++R +L GG +YAIGG DDN CF E Y E+DQW+ + +
Sbjct: 392 KWMMKASMNTKRRGIALASLGGPIYAIGGLDDN----TCFNDVERYDIESDQWSTVAPMN 447
Query: 67 TARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKD 126
T R GV AL + +GG L VE Y+ KW + + + G V+
Sbjct: 448 TPRGGVGSVALVNHVYAVGG-NDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLH 506
Query: 127 YRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSK 186
+Y GG D P + ++ YD + W +A + TPR KI+ +GG
Sbjct: 507 GCLYVVGGFD-DNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN 565
Query: 187 YAVNAFEVFDIETRSWTKFPNIPYKRA 213
+N E FD W ++ + RA
Sbjct: 566 AYLNTVEAFDPVLNRWELVGSVSHCRA 592
Score = 87.8 bits (216), Expect = 1e-17
Identities = 66/256 (25%), Positives = 112/256 (43%), Gaps = 11/256 (4%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E ++ W + SRR + ++ G+VYA+GG D N + E++ P ++W
Sbjct: 336 IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN-EHLGSMEMFDPLTNKWM 394
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ T R G+A+ +LG I IGG+ N VE Y+I+ +W + + G+
Sbjct: 395 MKASMNTKRRGIALASLGGPIYAIGGLDDNTC-FNDVERYDIESDQWSTVAPMNTPRGGV 453
Query: 121 SVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYA-ATSFLRGSKIYV 179
A VYA GG + + ++ YD D W+ + M R S L G +YV
Sbjct: 454 GSVALVNHVYAVGGND-GMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGC-LYV 511
Query: 180 LGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQP 239
+GG +++ E +D + W + R T+ ++++GG G Y
Sbjct: 512 VGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG-HNGNAY--- 567
Query: 240 KFLRTMDVFDMEQGGW 255
L T++ FD W
Sbjct: 568 --LNTVEAFDPVLNRW 581
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 106 bits (264), Expect = 4e-23
Identities = 81/293 (27%), Positives = 128/293 (43%), Gaps = 15/293 (5%)
Query: 36 IGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGV-GTNQLPL 94
+GG P+D E Y P+ +W+ LP + R VA +L RI VIGG G ++L
Sbjct: 286 VGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSS 345
Query: 95 KVVEMYNIDE-GKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKD 153
Y DE G W + + T +Y +GG R H ++ YD D
Sbjct: 346 VECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFD-GSRRHTSMERYDPNID 404
Query: 154 MWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRA 213
W L M T R A + IY LGG +N+ E +D T WT + KR+
Sbjct: 405 QWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRS 464
Query: 214 FSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVA 273
+ L++H+Y +GG + L +++ +++ W + + R A
Sbjct: 465 GAGVALLNDHIYVVGG------FDGTAHLSSVEAYNIRTDSWTTVTS---MTTPRCYVGA 515
Query: 274 GSLSGRV-IVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
L GR+ +AG GN ++L + E + P + WE++ +M T RC V++
Sbjct: 516 TVLRGRLYAIAGYDGN--SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLR 566
Score = 85.5 bits (210), Expect = 6e-17
Identities = 76/286 (26%), Positives = 124/286 (43%), Gaps = 19/286 (6%)
Query: 55 EADQWTALPRLPTARAGVAVTA-LGKR--IMVIGGVGTNQLPLKVVEMYNIDEGKWK-KR 110
EA ++ P L + G A LG ++V+GG G+ Q P+ VVE Y+ +W
Sbjct: 254 EAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLP 313
Query: 111 SMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKD---MWVSLAPMPTPRYA 167
S+ R+ SV+ D R+Y GG R + ++ D D +W S+APM R
Sbjct: 314 SITRKRRYVASVSLHD-RIYVIGGYDGRSR-LSSVECLDYTADEDGVWYSVAPMNVRRGL 371
Query: 168 ATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSL 227
A + G IYV GG + E +D W+ ++ R + V +Y L
Sbjct: 372 AGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCL 431
Query: 228 GGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLG 287
GG Y L +++ +D G W + + +R+ L+ + V GG
Sbjct: 432 GG------YDGLNILNSVEKYDPHTGHWTNVTP---MATKRSGAGVALLNDHIYVVGGF- 481
Query: 288 NQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
+ L + EA++ + W + +M TPRC + V++ L A+ G
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG 527
Score = 83.6 bits (205), Expect = 2e-16
Identities = 61/252 (24%), Positives = 106/252 (42%), Gaps = 12/252 (4%)
Query: 7 KDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNG--VPMDCFEVYSPEADQWTALPR 64
K +W L + +R Y + + ++Y IGG D ++C + + E W ++
Sbjct: 305 KTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAP 364
Query: 65 LPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
+ R T LG I V GG ++ +E Y+ + +W ++ A G +
Sbjct: 365 MNVRRGLAGATTLGDMIYVSGGFDGSRRHTS-MERYDPNIDQWSMLGDMQTAREGAGLVV 423
Query: 125 KDYRVYAAGGM-GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGR 183
+Y GG GL++ N ++ YD W ++ PM T R A L IYV+GG
Sbjct: 424 ASGVIYCLGGYDGLNIL--NSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF 481
Query: 184 QSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLR 243
+++ E ++I T SWT ++ R + L LY++ G Y L
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG------YDGNSLLS 535
Query: 244 TMDVFDMEQGGW 255
+++ +D W
Sbjct: 536 SIECYDPIIDSW 547
Score = 41.2 bits (95), Expect = 0.001
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 1/80 (1%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N++ W + + + R Y G++YAI G D N + + E Y P D W
Sbjct: 490 VEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPIIDSWE 548
Query: 61 ALPRLPTARAGVAVTALGKR 80
+ + T R V L ++
Sbjct: 549 VVTSMGTQRCDAGVCVLREK 568
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 103 bits (258), Expect = 2e-22
Identities = 78/315 (24%), Positives = 143/315 (45%), Gaps = 20/315 (6%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTAR 69
Q ++ P R Y L GG GG + + C E + + WT + L AR
Sbjct: 276 QTSKVRPRKKARKY--LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQAR 333
Query: 70 AGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRV 129
+G+ VT LG + IGG + + E Y+ +W + + G+ V +
Sbjct: 334 SGLGVTVLGGMVYAIGGEKDSMI-FDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAI 392
Query: 130 YAAGG-MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSK-Y 187
YA GG +G ++ N ++ +D ++ W + M RY IYV+GG ++
Sbjct: 393 YALGGWVGAEI--GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI 450
Query: 188 AVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDV 247
+ +FEV+D ++ W+ P + +RA+ L++ +YS+GG + + L T++
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ-----DALHTVEK 505
Query: 248 FDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQ-----PTVLETAEAFHPG 302
+ E+ W+++ +K RA +++G + V+GG + P L++ E ++P
Sbjct: 506 YSFEEEKWVEVAS---MKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPH 562
Query: 303 KNKWEILPAMPTPRC 317
+ W + M T RC
Sbjct: 563 SDTWTEIGNMITSRC 577
Score = 80.9 bits (198), Expect = 2e-15
Identities = 67/268 (25%), Positives = 104/268 (38%), Gaps = 9/268 (3%)
Query: 66 PTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
P +A + A+G + GG ++ L VE ++ W S L +A G+ VT
Sbjct: 282 PRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVL 341
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQS 185
VYA GG D + + YD + W ++A M PR + IY LGG
Sbjct: 342 GGMVYAIGGEK-DSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVG 400
Query: 186 KYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTM 245
N E FD + W N+ R + + +Y +GG+ + LR+
Sbjct: 401 AEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE-----LRSF 455
Query: 246 DVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNK 305
+V+D W + + RRA +L+ + GG L T E + + K
Sbjct: 456 EVYDPLSKRWSPLPP---MGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEK 512
Query: 306 WEILPAMPTPRCACSSIVVKNCLLAVGG 333
W + +M PR + V L GG
Sbjct: 513 WVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/204 (22%), Positives = 86/204 (42%), Gaps = 9/204 (4%)
Query: 133 GGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAF 192
GG D R + ++ +D W +++ + R + G +Y +GG + +
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 193 EVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQ 252
E +D T+ WT ++ + R +Y+LGG + + T++ FD ++
Sbjct: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGG------WVGAEIGNTIERFDPDE 414
Query: 253 GGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAM 312
W + + R F + G + V GG+ N+ L + E + P +W LP M
Sbjct: 415 NKWEVVGN---MAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
Query: 313 PTPRCACSSIVVKNCLLAVGGVNQ 336
T R + +C+ +VGG N+
Sbjct: 472 GTRRAYLGVAALNDCIYSVGGWNE 495
Score = 34.7 bits (78), Expect = 0.13
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGG---CDDNGVP--MDCFEVYSPE 55
+E + ++ +W +A + R ++ G +Y GG D P +D EVY+P
Sbjct: 503 VEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPH 562
Query: 56 ADQWTALPRLPTAR--AGVAV 74
+D WT + + T+R GVAV
Sbjct: 563 SDTWTEIGNMITSRCEGGVAV 583
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 101 bits (251), Expect = 1e-21
Identities = 65/263 (24%), Positives = 115/263 (43%), Gaps = 8/263 (3%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N W LAP+ + R + GQ+Y +GG + + + C E+Y D W
Sbjct: 385 VECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWI 444
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGT-NQLPLKVVEMYNIDEGKWKKRSMLREAAMG 119
+P L T R V AL ++ ++GG Q LK ++++ W + L
Sbjct: 445 PVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQ 504
Query: 120 ISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
+V +Y GG N ++ Y+ + W +APM R A + K++V
Sbjct: 505 SAVCELGGYLYIIGG-AESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFV 563
Query: 180 LGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQP 239
GG +A++ E++D W N+ R+ + T+ N +Y++GG +
Sbjct: 564 CGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG------FDGN 617
Query: 240 KFLRTMDVFDMEQGGWLKMERSF 262
+FL T++V+++E W + F
Sbjct: 618 EFLNTVEVYNLESNEWSPYTKIF 640
Score = 81.3 bits (199), Expect = 1e-15
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 15/286 (5%)
Query: 52 YSPEADQWTALPRLPT--ARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKK 109
+ + D+ P P AR+G+ + +++ GG + L+ VE YN W
Sbjct: 339 FEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREEC-LRTVECYNPHTDHWSF 397
Query: 110 RSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAAT 169
+ +R + ++Y GG + + YD D W+ + + T R A
Sbjct: 398 LAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAG 457
Query: 170 SFLRGSKIYVLGGRQ--SKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSL 227
K+Y++GG + + +VFD T+ WT + +R S+ L +LY +
Sbjct: 458 VCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYII 517
Query: 228 GGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLG 287
GG L T++ ++ E W + + R L+G++ V GG
Sbjct: 518 GGAESWNC------LNTVERYNPENNTWTLIAP---MNVARRGAGVAVLNGKLFVCGGFD 568
Query: 288 NQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
+ E + P +N+W+++ M +PR V N + AVGG
Sbjct: 569 GSHAI-SCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG 613
Score = 45.4 bits (106), Expect = 7e-05
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 239 PKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEA 298
PK +++ F+M+Q ++ S ++ R+ ++G++I AGG N+ L T E
Sbjct: 331 PKLSKSLS-FEMQQDELIEKPMSP-MQYARSGLGTAEMNGKLIAAGGY-NREECLRTVEC 387
Query: 299 FHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSD 340
++P + W L M TPR V+ L VGG N G SD
Sbjct: 388 YNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSN-GHSD 428
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 99.8 bits (247), Expect = 3e-21
Identities = 62/225 (27%), Positives = 105/225 (46%), Gaps = 7/225 (3%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N K W L P+ + R + G +YA+GG D ++ E + P++ QWT
Sbjct: 523 VECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGG-HDGWSYLNTVERWDPQSQQWT 581
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ + AR+ V V AL ++ +GG + L +E Y+ KW + + + G+
Sbjct: 582 FVASMSIARSTVGVAALNGKLYSVGGRDGSSC-LSSMEYYDPHTNKWNMCAPMCKRRGGV 640
Query: 121 SVTAKDYRVYAAGGMGLDLRPH-----NHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGS 175
V D +YA GG H ++++ YD D W +AP+ PR A L G
Sbjct: 641 GVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGD 700
Query: 176 KIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
++Y +GG + +N E +D +T WT+ ++ RA + V +
Sbjct: 701 RLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
Score = 87.0 bits (214), Expect = 2e-17
Identities = 72/297 (24%), Positives = 113/297 (38%), Gaps = 7/297 (2%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G +YA+GG D+N E Y + W + R V + ++ VIGG
Sbjct: 457 TVGTLYAVGGMDNNK-GATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGG-R 514
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
L VE YN W + G+ VT + +YA GG N ++ +
Sbjct: 515 DGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHD-GWSYLNTVERW 573
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D W +A M R K+Y +GGR +++ E +D T W +
Sbjct: 574 DPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPM 633
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+R T D LY++GG + L ++ +D + W + L R
Sbjct: 634 CKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAP---LSMPR 690
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
L R+ GG Q T L T E++ P N+W + ++ R +V+K
Sbjct: 691 DAVGVCLLGDRLYAVGGYDGQ-TYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
Score = 74.3 bits (181), Expect = 1e-13
Identities = 60/258 (23%), Positives = 107/258 (41%), Gaps = 16/258 (6%)
Query: 81 IMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLR 140
+ +GG+ N+ +E Y++ W + M+ + V D +++ GG L+
Sbjct: 461 LYAVGGMDNNK-GATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD-GLK 518
Query: 141 PHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETR 200
N ++ Y+ W L PM T R+ + IY +GG +N E +D +++
Sbjct: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
Query: 201 SWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMER 260
WT ++ R+ L+ LYS+GG R G L +M+ +D W
Sbjct: 579 QWTFVASMSIARSTVGVAALNGKLYSVGG-RDGS-----SCLSSMEYYDPHTNKWNMCAP 632
Query: 261 SFFLKKRRADFVAGSLSGRVIVAGG-----LGNQPTVLETAEAFHPGKNKWEILPAMPTP 315
+ KRR + G + GG + +L+ E + P + W ++ + P
Sbjct: 633 ---MCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMP 689
Query: 316 RCACSSIVVKNCLLAVGG 333
R A ++ + L AVGG
Sbjct: 690 RDAVGVCLLGDRLYAVGG 707
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 97.1 bits (240), Expect = 2e-20
Identities = 64/225 (28%), Positives = 105/225 (46%), Gaps = 7/225 (3%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N K W + P+ + R + G +YA+GG D ++ E + P+A QW
Sbjct: 485 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWN 543
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ + T R+ V V L ++ +GG + LK VE ++ KW + + + G+
Sbjct: 544 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGV 602
Query: 121 SVTAKDYRVYAAGG-----MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGS 175
VT + +YA GG L R + ++ YD DMW ++A M R A L G
Sbjct: 603 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 662
Query: 176 KIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
K+Y +GG + +N E +D +T WT+ + RA + VT+
Sbjct: 663 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 707
Score = 85.5 bits (210), Expect = 6e-17
Identities = 71/297 (23%), Positives = 112/297 (37%), Gaps = 7/297 (2%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G ++A+GG D E Y + WT + + R V L ++ V+GG
Sbjct: 419 TVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-R 476
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
L VE YN W + G+ V + +YA GG N ++ +
Sbjct: 477 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWSYLNTVERW 535
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D W +A M TPR + K+Y +GGR + + E FD T WT +
Sbjct: 536 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQM 595
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+R T + LY++GG + ++ +D + W + +
Sbjct: 596 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISR--- 652
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
D V L G + A G + L T EA+ P N+W + + R + VK
Sbjct: 653 -DAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 708
Score = 72.0 bits (175), Expect = 7e-13
Identities = 55/222 (24%), Positives = 95/222 (42%), Gaps = 18/222 (8%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
++A GGM + ++ YD+ +MW +A M R + K+YV+GGR
Sbjct: 423 LFAVGGMD-STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 481
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+N E ++ +T++W+ P + R L+ +Y++GG + +L T++ +
Sbjct: 482 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG------HDGWSYLNTVERW 535
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D + W + + R+ LSG++ GG + L++ E F P NKW +
Sbjct: 536 DPQARQWNFVAT---MSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTL 591
Query: 309 LPAMPTPRCACSSIVVKNCLLAVGG-------VNQGLSDAVE 343
M R L A+GG + LSD VE
Sbjct: 592 CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 633
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/288 (22%), Positives = 116/288 (40%), Gaps = 18/288 (6%)
Query: 63 PRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISV 122
P L + R + +G + +GG+ + + + E Y++ W + + + V
Sbjct: 406 PMLQSPRTKPRKSTVGT-LFAVGGMDSTKGATSI-EKYDLRTNMWTPVANMNGRRLQFGV 463
Query: 123 TAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGG 182
D ++Y GG L+ N ++ Y+ W + PM T R+ + +Y +GG
Sbjct: 464 AVLDDKLYVVGGRD-GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG 522
Query: 183 RQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFL 242
+N E +D + R W + R+ L LY++GG R G L
Sbjct: 523 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGS-----SCL 576
Query: 243 RTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVL-----ETAE 297
++++ FD W + + KRR + +G + GG + L + E
Sbjct: 577 KSVECFDPHTNKWTLCAQ---MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 633
Query: 298 AFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVN-QGLSDAVEA 344
+ P + W + +M R A ++ + L AVGG + Q + VEA
Sbjct: 634 RYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEA 681
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 97.1 bits (240), Expect = 2e-20
Identities = 64/225 (28%), Positives = 105/225 (46%), Gaps = 7/225 (3%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N K W + P+ + R + G +YA+GG D ++ E + P+A QW
Sbjct: 470 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWN 528
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ + T R+ V V L ++ +GG + LK VE ++ KW + + + G+
Sbjct: 529 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGV 587
Query: 121 SVTAKDYRVYAAGG-----MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGS 175
VT + +YA GG L R + ++ YD DMW ++A M R A L G
Sbjct: 588 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 647
Query: 176 KIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
K+Y +GG + +N E +D +T WT+ + RA + VT+
Sbjct: 648 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
Score = 85.5 bits (210), Expect = 6e-17
Identities = 71/297 (23%), Positives = 112/297 (37%), Gaps = 7/297 (2%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G ++A+GG D E Y + WT + + R V L ++ V+GG
Sbjct: 404 TVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-R 461
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
L VE YN W + G+ V + +YA GG N ++ +
Sbjct: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWSYLNTVERW 520
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D W +A M TPR + K+Y +GGR + + E FD T WT +
Sbjct: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQM 580
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+R T + LY++GG + ++ +D + W + +
Sbjct: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISR--- 637
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
D V L G + A G + L T EA+ P N+W + + R + VK
Sbjct: 638 -DAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693
Score = 72.0 bits (175), Expect = 7e-13
Identities = 55/222 (24%), Positives = 95/222 (42%), Gaps = 18/222 (8%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
++A GGM + ++ YD+ +MW +A M R + K+YV+GGR
Sbjct: 408 LFAVGGMD-STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 466
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+N E ++ +T++W+ P + R L+ +Y++GG + +L T++ +
Sbjct: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG------HDGWSYLNTVERW 520
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D + W + + R+ LSG++ GG + L++ E F P NKW +
Sbjct: 521 DPQARQWNFVAT---MSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTL 576
Query: 309 LPAMPTPRCACSSIVVKNCLLAVGG-------VNQGLSDAVE 343
M R L A+GG + LSD VE
Sbjct: 577 CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 618
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/288 (22%), Positives = 116/288 (40%), Gaps = 18/288 (6%)
Query: 63 PRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISV 122
P L + R + +G + +GG+ + + + E Y++ W + + + V
Sbjct: 391 PMLQSPRTKPRKSTVGT-LFAVGGMDSTKGATSI-EKYDLRTNMWTPVANMNGRRLQFGV 448
Query: 123 TAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGG 182
D ++Y GG L+ N ++ Y+ W + PM T R+ + +Y +GG
Sbjct: 449 AVLDDKLYVVGGRD-GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG 507
Query: 183 RQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFL 242
+N E +D + R W + R+ L LY++GG R G L
Sbjct: 508 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGS-----SCL 561
Query: 243 RTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVL-----ETAE 297
++++ FD W + + KRR + +G + GG + L + E
Sbjct: 562 KSVECFDPHTNKWTLCAQ---MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 618
Query: 298 AFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVN-QGLSDAVEA 344
+ P + W + +M R A ++ + L AVGG + Q + VEA
Sbjct: 619 RYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEA 666
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 97.1 bits (240), Expect = 2e-20
Identities = 64/225 (28%), Positives = 105/225 (46%), Gaps = 7/225 (3%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N K W + P+ + R + G +YA+GG D ++ E + P+A QW
Sbjct: 531 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWN 589
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ + T R+ V V L ++ +GG + LK VE ++ KW + + + G+
Sbjct: 590 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGV 648
Query: 121 SVTAKDYRVYAAGG-----MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGS 175
VT + +YA GG L R + ++ YD DMW ++A M R A L G
Sbjct: 649 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 708
Query: 176 KIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
K+Y +GG + +N E +D +T WT+ + RA + VT+
Sbjct: 709 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
Score = 85.5 bits (210), Expect = 6e-17
Identities = 71/297 (23%), Positives = 112/297 (37%), Gaps = 7/297 (2%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G ++A+GG D E Y + WT + + R V L ++ V+GG
Sbjct: 465 TVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-R 522
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
L VE YN W + G+ V + +YA GG N ++ +
Sbjct: 523 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWSYLNTVERW 581
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D W +A M TPR + K+Y +GGR + + E FD T WT +
Sbjct: 582 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQM 641
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+R T + LY++GG + ++ +D + W + +
Sbjct: 642 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISR--- 698
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
D V L G + A G + L T EA+ P N+W + + R + VK
Sbjct: 699 -DAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 754
Score = 72.0 bits (175), Expect = 7e-13
Identities = 55/222 (24%), Positives = 95/222 (42%), Gaps = 18/222 (8%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
++A GGM + ++ YD+ +MW +A M R + K+YV+GGR
Sbjct: 469 LFAVGGMD-STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 527
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+N E ++ +T++W+ P + R L+ +Y++GG + +L T++ +
Sbjct: 528 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG------HDGWSYLNTVERW 581
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D + W + + R+ LSG++ GG + L++ E F P NKW +
Sbjct: 582 DPQARQWNFVAT---MSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTL 637
Query: 309 LPAMPTPRCACSSIVVKNCLLAVGG-------VNQGLSDAVE 343
M R L A+GG + LSD VE
Sbjct: 638 CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 679
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/288 (22%), Positives = 116/288 (40%), Gaps = 18/288 (6%)
Query: 63 PRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISV 122
P L + R + +G + +GG+ + + + E Y++ W + + + V
Sbjct: 452 PMLQSPRTKPRKSTVGT-LFAVGGMDSTKGATSI-EKYDLRTNMWTPVANMNGRRLQFGV 509
Query: 123 TAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGG 182
D ++Y GG L+ N ++ Y+ W + PM T R+ + +Y +GG
Sbjct: 510 AVLDDKLYVVGGRD-GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG 568
Query: 183 RQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFL 242
+N E +D + R W + R+ L LY++GG R G L
Sbjct: 569 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGS-----SCL 622
Query: 243 RTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVL-----ETAE 297
++++ FD W + + KRR + +G + GG + L + E
Sbjct: 623 KSVECFDPHTNKWTLCAQ---MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 679
Query: 298 AFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVN-QGLSDAVEA 344
+ P + W + +M R A ++ + L AVGG + Q + VEA
Sbjct: 680 RYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEA 727
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 96.3 bits (238), Expect = 4e-20
Identities = 62/247 (25%), Positives = 116/247 (46%), Gaps = 10/247 (4%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTA-LPRLPTA 68
+W+ +A + RR + +YA+GG D + ++ E Y P+ +QW++ + T
Sbjct: 344 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSY-LNSVERYDPKTNQWSSDVAPTSTC 402
Query: 69 RAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYR 128
R V V LG + +GG L +VE Y+ E KW + + + +G++V
Sbjct: 403 RTSVGVAVLGGFLYAVGGQDGVSC-LNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGF 461
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
+YA GG P N ++ Y+ ++ W ++APM T R + IY +GGR
Sbjct: 462 LYAVGGSD-GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE 520
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+++ E ++ T W+ + +R+ ++ L ++GG + +L+T++VF
Sbjct: 521 LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG------FDGTTYLKTIEVF 574
Query: 249 DMEQGGW 255
D + W
Sbjct: 575 DPDANTW 581
Score = 78.6 bits (192), Expect = 8e-15
Identities = 62/257 (24%), Positives = 112/257 (43%), Gaps = 13/257 (5%)
Query: 78 GKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGL 137
G+ + +GG + + VE Y+ +W+ + + + G+ V+ D +YA GG
Sbjct: 317 GEVLFAVGGWCSGDA-ISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD- 374
Query: 138 DLRPHNHLQHYDMLKDMWVS-LAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFD 196
N ++ YD + W S +AP T R + + G +Y +GG+ +N E +D
Sbjct: 375 GSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYD 434
Query: 197 IETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWL 256
+ WT+ ++ +R + L LY++GG L T++ ++ ++ W
Sbjct: 435 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDG------TSPLNTVERYNPQENRWH 488
Query: 257 KMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPR 316
+ + RR + GG + T L +AE ++P N+W + AM + R
Sbjct: 489 TIAP---MGTRRKHLGCAVYQDMIYAVGGR-DDTTELSSAERYNPRTNQWSPVVAMTSRR 544
Query: 317 CACSSIVVKNCLLAVGG 333
VV L+AVGG
Sbjct: 545 SGVGLAVVNGQLMAVGG 561
Score = 75.1 bits (183), Expect = 9e-14
Identities = 65/301 (21%), Positives = 120/301 (39%), Gaps = 16/301 (5%)
Query: 27 LETGGQVYAIGG-CDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIG 85
+ G ++A+GG C +G + E Y P+ ++W + + R GV V+ L + +G
Sbjct: 314 IRCGEVLFAVGGWC--SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVG 371
Query: 86 GVGTNQLPLKVVEMYNIDEGKWKKR-SMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNH 144
G + L VE Y+ +W + + V +YA GG + N
Sbjct: 372 GHDGSSY-LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQD-GVSCLNI 429
Query: 145 LQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTK 204
++ YD ++ W +A M T R + G +Y +GG +N E ++ + W
Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHT 489
Query: 205 FPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFL 264
+ +R + +Y++GG L + + ++ W + +
Sbjct: 490 IAPMGTRRKHLGCAVYQDMIYAVGG------RDDTTELSSAERYNPRTNQWSPV---VAM 540
Query: 265 KKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVV 324
RR+ ++G+++ GG + T L+T E F P N W + M R V+
Sbjct: 541 TSRRSGVGLAVVNGQLMAVGGF-DGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
Query: 325 K 325
K
Sbjct: 600 K 600
Score = 60.1 bits (144), Expect = 3e-09
Identities = 30/105 (28%), Positives = 57/105 (54%), Gaps = 4/105 (3%)
Query: 5 NVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPR 64
N ++ +W +AP+ +RR + +YA+GG DD + E Y+P +QW+ +
Sbjct: 481 NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDT-TELSSAERYNPRTNQWSPVVA 539
Query: 65 LPTARAGVAVTALGKRIMVIGGV-GTNQLPLKVVEMYNIDEGKWK 108
+ + R+GV + + ++M +GG GT LK +E+++ D W+
Sbjct: 540 MTSRRSGVGLAVVNGQLMAVGGFDGTTY--LKTIEVFDPDANTWR 582
Score = 57.0 bits (136), Expect = 2e-08
Identities = 32/128 (25%), Positives = 60/128 (46%), Gaps = 2/128 (1%)
Query: 7 KDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLP 66
K+ +W R+A + +RR+ ++ GG +YA+GG D P++ E Y+P+ ++W + +
Sbjct: 436 KENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS-PLNTVERYNPQENRWHTIAPMG 494
Query: 67 TARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKD 126
T R + I +GG + L E YN +W + G+ + +
Sbjct: 495 TRRKHLGCAVYQDMIYAVGG-RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVN 553
Query: 127 YRVYAAGG 134
++ A GG
Sbjct: 554 GQLMAVGG 561
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 94.0 bits (232), Expect = 2e-19
Identities = 73/251 (29%), Positives = 113/251 (45%), Gaps = 19/251 (7%)
Query: 15 APLPSRRVYCSLLETGGQVYAIGGC-DDNGVPMDCFEVYSPEADQWTALPRLPTARAGVA 73
A LPS R S G +VY GG +NGV D + VY ++W+ + AR G
Sbjct: 324 ADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVW-VYDTVHEEWSKAAPMLIARFGHG 382
Query: 74 VTALGKRIMVIGG--------VGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
L + V+GG + + LK VE Y+ KW + LR+ +V +
Sbjct: 383 SAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSA 442
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTP-RYAATSFLRGSKIYVLGGRQ 184
+++ GG + + +Q YD ++ W A P P RY A + L GS+I+++GG
Sbjct: 443 KLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVL-GSQIFIMGGDT 501
Query: 185 SKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRT 244
A +A+ FD ET WT+ ++ KR + N LY +GG Y + +T
Sbjct: 502 EFTAASAYR-FDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGG------YFGTQRCKT 554
Query: 245 MDVFDMEQGGW 255
+D +D W
Sbjct: 555 LDCYDPTSDTW 565
Score = 52.4 bits (124), Expect = 6e-07
Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 7/179 (3%)
Query: 159 APMPTPRYAATSFLRGSKIYVLGGRQSKYAVNA-FEVFDIETRSWTKFPNIPYKRAFSSF 217
A +P+PR ++ G K+YV GGR S+ V+ V+D W+K + R
Sbjct: 324 ADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGS 383
Query: 218 VTLDNHLYSLGGLRQ--GRLYRQPKF-LRTMDVFDMEQGGWLKMERSFFLKKRRADFVAG 274
L+N LY +GG G P L+ ++ +D W+ + L+ ++
Sbjct: 384 AELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAP---LRDGVSNAAVV 440
Query: 275 SLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
S ++ V GG ++ + + P +N+W I P P ++ V+ + + +GG
Sbjct: 441 SAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG 499
Score = 43.5 bits (101), Expect = 3e-04
Identities = 48/222 (21%), Positives = 82/222 (36%), Gaps = 19/222 (8%)
Query: 121 SVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVL 180
S +A +VY GG G + + YD + + W APM R+ S + +YV+
Sbjct: 334 SASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVV 393
Query: 181 GGRQS---------KYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLR 231
GG S ++ E +D W + + ++ V+ L+ GG
Sbjct: 394 GGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTS 453
Query: 232 QGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPT 291
R + + +D + W + A V GS ++ + GG +
Sbjct: 454 IHR-----DMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGS---QIFIMGG--DTEF 503
Query: 292 VLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
+A F N+W + M R +C ++ N L VGG
Sbjct: 504 TAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGG 545
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 92.4 bits (228), Expect = 5e-19
Identities = 77/251 (30%), Positives = 115/251 (45%), Gaps = 19/251 (7%)
Query: 15 APLPSRRVYCSLLETGGQVYAIGGC-DDNGVPMDCFEVYSPEADQWTALPRLPTARAGVA 73
A +PS R S G +VY GG +NGV D + VY ++W+ + AR G
Sbjct: 324 ADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVW-VYDTLHEEWSKAAPMLVARFGHG 382
Query: 74 VTALGKRIMVIGG--VGTNQLP------LKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
L + V+GG T LP LK VE Y+ KW + LRE +V +
Sbjct: 383 SAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSA 442
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTP-RYAATSFLRGSKIYVLGGRQ 184
+++A GG + +Q YD ++ W A P P RY A + L G++I+++GG
Sbjct: 443 KLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVL-GNQIFIMGGDT 501
Query: 185 SKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRT 244
A +A++ F+ ET WTK ++ KR V N LY +GG Y + +T
Sbjct: 502 EFSACSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGG------YFGIQRCKT 554
Query: 245 MDVFDMEQGGW 255
+D +D W
Sbjct: 555 LDCYDPTLDVW 565
Score = 44.3 bits (103), Expect = 2e-04
Identities = 41/179 (22%), Positives = 75/179 (41%), Gaps = 7/179 (3%)
Query: 159 APMPTPRYAATSFLRGSKIYVLGGRQSKYAVNA-FEVFDIETRSWTKFPNIPYKRAFSSF 217
A +P+PR ++ G K+Y+ GGR S+ V+ V+D W+K + R
Sbjct: 324 ADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGS 383
Query: 218 VTLDNHLYSLGG--LRQGRLYRQPKF-LRTMDVFDMEQGGWLKMERSFFLKKRRADFVAG 274
L + LY +GG G L P L+ ++ +D W + L++ ++
Sbjct: 384 AELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAP---LREGVSNAAVV 440
Query: 275 SLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
S ++ GG L + + +N+W + P P ++ V+ N + +GG
Sbjct: 441 SAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG 499
Score = 37.7 bits (86), Expect = 0.015
Identities = 18/79 (22%), Positives = 38/79 (48%), Gaps = 5/79 (6%)
Query: 5 NVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGC--DDNGVPMDCFEVYSPEADQWTAL 62
N + +QW ++ + ++R+ C + +G ++Y +GG +DC Y P D W ++
Sbjct: 512 NSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDC---YDPTLDVWNSI 568
Query: 63 PRLPTARAGVAVTALGKRI 81
+P + A + K +
Sbjct: 569 TTVPYSLIPTAFVSTWKHL 587
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 91.7 bits (226), Expect = 9e-19
Identities = 73/301 (24%), Positives = 134/301 (44%), Gaps = 16/301 (5%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTAR 69
Q ++ P R Y L GG GG + + C E + + WT + L AR
Sbjct: 276 QTSKVRPRKKARKY--LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQAR 333
Query: 70 AGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRV 129
+G+ VT LG + IGG + + E Y+ +W + + G+ V +
Sbjct: 334 SGLGVTVLGGMVYAIGGEKDSMI-FDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAI 392
Query: 130 YAAGG-MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSK-Y 187
YA GG +G ++ N ++ +D ++ W + M RY IYV+GG ++
Sbjct: 393 YALGGWVGAEI--GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI 450
Query: 188 AVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDV 247
+ +FEV+D ++ W+ P + +RA+ L++ +YS+GG + + L T++
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ-----DALHTVEK 505
Query: 248 FDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVL-ETAEAFHPGKNKW 306
+ E+ W+++ +K RA +++G + V+GG + L + + KW
Sbjct: 506 YSFEEEKWVEVAS---MKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKW 562
Query: 307 E 307
E
Sbjct: 563 E 563
Score = 82.0 bits (201), Expect = 7e-16
Identities = 46/152 (30%), Positives = 75/152 (49%), Gaps = 5/152 (3%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTAR 69
+W+ + + R Y E G +Y IGG + G+ + FEVY P + +W+ LP + T R
Sbjct: 416 KWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRR 475
Query: 70 AGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRV 129
A + V AL I +GG Q L VE Y+ +E KW + + ++ G+ V A + +
Sbjct: 476 AYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLL 535
Query: 130 YAAGGMGLD---LRPHNHLQHYDMLKDMWVSL 158
Y +GG L P H Y++ + W ++
Sbjct: 536 YVSGGRSSSHDFLAPDTH--RYEVFRLKWENM 565
Score = 80.9 bits (198), Expect = 2e-15
Identities = 67/268 (25%), Positives = 104/268 (38%), Gaps = 9/268 (3%)
Query: 66 PTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
P +A + A+G + GG ++ L VE ++ W S L +A G+ VT
Sbjct: 282 PRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVL 341
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQS 185
VYA GG D + + YD + W ++A M PR + IY LGG
Sbjct: 342 GGMVYAIGGEK-DSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVG 400
Query: 186 KYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTM 245
N E FD + W N+ R + + +Y +GG+ + LR+
Sbjct: 401 AEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE-----LRSF 455
Query: 246 DVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNK 305
+V+D W + + RRA +L+ + GG L T E + + K
Sbjct: 456 EVYDPLSKRWSPLPP---MGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEK 512
Query: 306 WEILPAMPTPRCACSSIVVKNCLLAVGG 333
W + +M PR + V L GG
Sbjct: 513 WVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/204 (22%), Positives = 86/204 (42%), Gaps = 9/204 (4%)
Query: 133 GGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAF 192
GG D R + ++ +D W +++ + R + G +Y +GG + +
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 193 EVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQ 252
E +D T+ WT ++ + R +Y+LGG + + T++ FD ++
Sbjct: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGG------WVGAEIGNTIERFDPDE 414
Query: 253 GGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAM 312
W + + R F + G + V GG+ N+ L + E + P +W LP M
Sbjct: 415 NKWEVVGN---MAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
Query: 313 PTPRCACSSIVVKNCLLAVGGVNQ 336
T R + +C+ +VGG N+
Sbjct: 472 GTRRAYLGVAALNDCIYSVGGWNE 495
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 91.3 bits (225), Expect = 1e-18
Identities = 78/322 (24%), Positives = 144/322 (44%), Gaps = 22/322 (6%)
Query: 7 KDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLP 66
++ Q R P S V ++ GG+ +G + V + C ++P+ ++W L LP
Sbjct: 567 QEMQTPRTRPRLSAGVAEVIVLVGGR-QMVGMTQRSLVAVTC---WNPQNNKWYPLASLP 622
Query: 67 TA-RAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
R +V + G I + GG+ + + L V Y W S + +
Sbjct: 623 FYDREFFSVVSAGDNIYLSGGMESG-VTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVY 681
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGG-RQ 184
D ++Y GG+G+ +H++ YD + + W ++AP+P ++A + + G KIYV GG +
Sbjct: 682 DGKIYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNE 740
Query: 185 SKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRT 244
+ A + + +T +W+ + ++ VTL+ ++ LGG + R
Sbjct: 741 AGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----------AYARA 790
Query: 245 MDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGL-GNQPTVLETAEAFHPGK 303
++D E+G ++ + R A L G++ GG+ ++ L EA+ P
Sbjct: 791 TTIYDPEKG---NIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTT 847
Query: 304 NKWEILPAMPTPRCACSSIVVK 325
N W +LP MP P +V+K
Sbjct: 848 NTWTLLPHMPCPVFRHGCVVIK 869
Score = 64.3 bits (155), Expect = 2e-10
Identities = 76/291 (26%), Positives = 114/291 (39%), Gaps = 34/291 (11%)
Query: 54 PEADQWTALPRL-PTARAGVAVTALGKRIMVIGG---VGTNQLPLKVVEMYNIDEGKWKK 109
P A Q PR P AGVA I+++GG VG Q L V +N KW
Sbjct: 563 PHARQEMQTPRTRPRLSAGVAEV-----IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYP 617
Query: 110 RSML----REAAMGISVTAKDYRVYAAGGM--GLDLRPHNHLQHYDMLKDMWVSLAPMPT 163
+ L RE SV + +Y +GGM G+ L + Y L D W ++ M
Sbjct: 618 LASLPFYDREF---FSVVSAGDNIYLSGGMESGVTLAD---VWCYMSLLDNWNLVSRMTV 671
Query: 164 PRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNH 223
PR S + KIY LGG V+ E +D T W +P ++
Sbjct: 672 PRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGK 731
Query: 224 LYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVA 283
+Y GG+ + + + + + W +E K A +L+G V +
Sbjct: 732 IYVFGGVNEAG-----RAAGVLQSYVPQTNTWSFIESPMIDNKYAP---AVTLNGFVFIL 783
Query: 284 GGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGV 334
GG + T + + P K + P M R CS++V+ + A GG+
Sbjct: 784 GGAYARATTI-----YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGI 829
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 143 NHLQHYDMLKDMWVSL-APMPTPRYAATSFLRGSKIYVLGGRQ----SKYAVNAFEVFDI 197
N + Y ML + P PR +A I ++GGRQ ++ ++ A ++
Sbjct: 554 NEAKRYHMLPHARQEMQTPRTRPRLSAGV---AEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
Query: 198 ETRSWTKFPNIP-YKRAFSSFVTLDNHLYSLGGLRQG-RLYRQPKFLRTMDVFDMEQGGW 255
+ W ++P Y R F S V+ +++Y GG+ G L ++ +D W
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD-------NW 663
Query: 256 LKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTP 315
+ R + R V G++ GGLG V + E + N+WE + +P
Sbjct: 664 NLVSRMTVPRCRHNSLV---YDGKIYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLPKA 719
Query: 316 RCACSSIVVKNCLLAVGGVNQ 336
+ ++ V + GGVN+
Sbjct: 720 VHSAAATVCGGKIYVFGGVNE 740
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 91.3 bits (225), Expect = 1e-18
Identities = 78/322 (24%), Positives = 144/322 (44%), Gaps = 22/322 (6%)
Query: 7 KDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLP 66
++ Q R P S V ++ GG+ +G + V + C ++P+ ++W L LP
Sbjct: 567 QEMQTPRTRPRLSAGVAEVIVLVGGR-QMVGMTQRSLVAVTC---WNPQNNKWYPLASLP 622
Query: 67 TA-RAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
R +V + G I + GG+ + + L V Y W S + +
Sbjct: 623 FYDREFFSVVSAGDNIYLSGGMESG-VTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVY 681
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGG-RQ 184
D ++Y GG+G+ +H++ YD + + W ++AP+P ++A + + G KIYV GG +
Sbjct: 682 DGKIYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNE 740
Query: 185 SKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRT 244
+ A + + +T +W+ + ++ VTL+ ++ LGG + R
Sbjct: 741 AGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----------AYARA 790
Query: 245 MDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGL-GNQPTVLETAEAFHPGK 303
++D E+G ++ + R A L G++ GG+ ++ L EA+ P
Sbjct: 791 TTIYDPEKG---NIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTT 847
Query: 304 NKWEILPAMPTPRCACSSIVVK 325
N W +LP MP P +V+K
Sbjct: 848 NTWTLLPHMPCPVFRHGCVVIK 869
Score = 64.3 bits (155), Expect = 2e-10
Identities = 76/291 (26%), Positives = 114/291 (39%), Gaps = 34/291 (11%)
Query: 54 PEADQWTALPRL-PTARAGVAVTALGKRIMVIGG---VGTNQLPLKVVEMYNIDEGKWKK 109
P A Q PR P AGVA I+++GG VG Q L V +N KW
Sbjct: 563 PHARQEMQTPRTRPRLSAGVAEV-----IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYP 617
Query: 110 RSML----REAAMGISVTAKDYRVYAAGGM--GLDLRPHNHLQHYDMLKDMWVSLAPMPT 163
+ L RE SV + +Y +GGM G+ L + Y L D W ++ M
Sbjct: 618 LASLPFYDREF---FSVVSAGDNIYLSGGMESGVTLAD---VWCYMSLLDNWNLVSRMTV 671
Query: 164 PRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNH 223
PR S + KIY LGG V+ E +D T W +P ++
Sbjct: 672 PRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGK 731
Query: 224 LYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVA 283
+Y GG+ + + + + + W +E K A +L+G V +
Sbjct: 732 IYVFGGVNEAG-----RAAGVLQSYVPQTNTWSFIESPMIDNKYAP---AVTLNGFVFIL 783
Query: 284 GGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGV 334
GG + T + + P K + P M R CS++V+ + A GG+
Sbjct: 784 GGAYARATTI-----YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGI 829
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 143 NHLQHYDMLKDMWVSL-APMPTPRYAATSFLRGSKIYVLGGRQ----SKYAVNAFEVFDI 197
N + Y ML + P PR +A I ++GGRQ ++ ++ A ++
Sbjct: 554 NEAKRYHMLPHARQEMQTPRTRPRLSAGV---AEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
Query: 198 ETRSWTKFPNIP-YKRAFSSFVTLDNHLYSLGGLRQG-RLYRQPKFLRTMDVFDMEQGGW 255
+ W ++P Y R F S V+ +++Y GG+ G L ++ +D W
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD-------NW 663
Query: 256 LKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTP 315
+ R + R V G++ GGLG V + E + N+WE + +P
Sbjct: 664 NLVSRMTVPRCRHNSLV---YDGKIYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLPKA 719
Query: 316 RCACSSIVVKNCLLAVGGVNQ 336
+ ++ V + GGVN+
Sbjct: 720 VHSAAATVCGGKIYVFGGVNE 740
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/248 (26%), Positives = 108/248 (43%), Gaps = 9/248 (3%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARA 70
W+R P+ + R + G +YAIGG D + + E Y+PE D WT + + + R+
Sbjct: 316 WERCRPMTTARSRVGVAVVNGLLYAIGGYDGQ-LRLSTVEAYNPETDTWTRVGSMNSKRS 374
Query: 71 GVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVY 130
+ L +I V GG N L VE Y+ + KW + + VT + R+Y
Sbjct: 375 AMGTVVLDGQIYVCGGYDGNS-SLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY 433
Query: 131 AAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVN 190
+GG L+ + ++HY+ W A M R + GSK++V GG ++
Sbjct: 434 VSGGHD-GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLS 492
Query: 191 AFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDM 250
E++ W + +R+ S V LY++GG Y L +++++D
Sbjct: 493 IAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG------YDGQSNLSSVEMYDP 546
Query: 251 EQGGWLKM 258
E W M
Sbjct: 547 ETDCWTFM 554
Score = 87.8 bits (216), Expect = 1e-17
Identities = 72/304 (23%), Positives = 120/304 (39%), Gaps = 20/304 (6%)
Query: 17 LPSRRVYCSLLET--------GGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTA 68
+P RR + T G +YA+GG + G ++ EV+ P A+ W + TA
Sbjct: 266 MPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTA 325
Query: 69 RAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYR 128
R+ V V + + IGG QL L VE YN + W + + + D +
Sbjct: 326 RSRVGVAVVNGLLYAIGGY-DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQ 384
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
+Y GG + + ++ Y D W + M + R AA + +IYV GG
Sbjct: 385 IYVCGGYDGN-SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQI 443
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
++ E ++ T +W + KR +L + ++ GG Y FL +++
Sbjct: 444 FSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGG------YDGSGFLSIAEMY 497
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
W + ++ R VA GR+ GG Q L + E + P + W
Sbjct: 498 SSVADQWCLIV-PMHTRRSRVSLVAS--CGRLYAVGGYDGQSN-LSSVEMYDPETDCWTF 553
Query: 309 LPAM 312
+ M
Sbjct: 554 MAPM 557
Score = 81.3 bits (199), Expect = 1e-15
Identities = 54/204 (26%), Positives = 88/204 (43%), Gaps = 5/204 (2%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E N + W R+ + S+R + GQ+Y GG D N + E YSPE D+WT
Sbjct: 353 VEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNS-SLSSVETYSPETDKWT 411
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ + + R+ VT RI V GG Q+ VE YN W + +
Sbjct: 412 VVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQI-FSSVEHYNHHTATWHPAAGMLNKRCRH 470
Query: 121 SVTAKDYRVYAAGGM-GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
+ +++ GG G + + Y + D W + PM T R + ++Y
Sbjct: 471 GAASLGSKMFVCGGYDGSGFL--SIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYA 528
Query: 180 LGGRQSKYAVNAFEVFDIETRSWT 203
+GG + +++ E++D ET WT
Sbjct: 529 VGGYDGQSNLSSVEMYDPETDCWT 552
Score = 72.4 bits (176), Expect = 6e-13
Identities = 62/272 (22%), Positives = 113/272 (41%), Gaps = 12/272 (4%)
Query: 63 PRLPTARAGV-AVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGIS 121
P LP R T++ I +GG+ + L VVE+++ W++ + A +
Sbjct: 271 PHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVG 330
Query: 122 VTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLG 181
V + +YA GG LR ++ Y+ D W + M + R A + + +IYV G
Sbjct: 331 VAVVNGLLYAIGGYDGQLRLST-VEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCG 389
Query: 182 GRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKF 241
G ++++ E + ET WT ++ R+ + + +Y GG + +
Sbjct: 390 GYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG------HDGLQI 443
Query: 242 LRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHP 301
+++ ++ W + + +R A SL ++ V GG L AE +
Sbjct: 444 FSSVEHYNHHTATW---HPAAGMLNKRCRHGAASLGSKMFVCGGYDGSG-FLSIAEMYSS 499
Query: 302 GKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
++W ++ M T R S + L AVGG
Sbjct: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGG 531
Score = 46.2 bits (108), Expect = 4e-05
Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTAR 69
QW + P+ +RR SL+ + G++YA+GG D + E+Y PE D WT + +
Sbjct: 503 QWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQS-NLSSVEMYDPETDCWTFMAPMACHE 561
Query: 70 AGVAV 74
GV V
Sbjct: 562 GGVGV 566
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 90.1 bits (222), Expect = 3e-18
Identities = 78/298 (26%), Positives = 131/298 (43%), Gaps = 17/298 (5%)
Query: 30 GGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGV-G 88
G ++A+GG + DC E Y D+W + + T RA V V A+G R+ +GG G
Sbjct: 341 GPVLFAVGGGSLFAIHGDC-EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDG 399
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
T+ L VE Y+ W+ + + V A +Y+AGG N + Y
Sbjct: 400 TSDLA--TVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYD-GASCLNSAERY 456
Query: 149 DMLKDMWVSLAPMPTPR-YAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPN 207
D L W S+A M T R Y + L G+ +Y +GG S + E ++ + W+ +
Sbjct: 457 DPLTGTWTSVAAMSTRRRYVRVATLDGN-LYAVGGYDSSSHLATVEKYEPQVNVWSPVAS 515
Query: 208 IPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKR 267
+ +R+ + L+ LY GG G L +++ + + G W + +++
Sbjct: 516 MLSRRSSAGVAVLEGALYVAGG-NDGT-----SCLNSVERYSPKAGAWESVA-PMNIRRS 568
Query: 268 RADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
D VA + G + GG + + L + E ++P NKW M T R + V++
Sbjct: 569 THDLVA--MDGWLYAVGG-NDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
Score = 74.3 bits (181), Expect = 1e-13
Identities = 55/229 (24%), Positives = 97/229 (42%), Gaps = 5/229 (2%)
Query: 2 EVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTA 61
E + + +W +A + +RR + G ++YA+GG D + E Y P + W
Sbjct: 360 EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTS-DLATVESYDPVTNTWQP 418
Query: 62 LPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGIS 121
+ T R+ + V AL + GG L E Y+ G W + + +
Sbjct: 419 EVSMGTRRSCLGVAALHGLLYSAGGYDGASC-LNSAERYDPLTGTWTSVAAMSTRRRYVR 477
Query: 122 VTAKDYRVYAAGGMGLDLRPH-NHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVL 180
V D +YA GG D H ++ Y+ ++W +A M + R +A + +YV
Sbjct: 478 VATLDGNLYAVGGY--DSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
Query: 181 GGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGG 229
GG +N+ E + + +W + +R+ V +D LY++GG
Sbjct: 536 GGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG 584
Score = 72.4 bits (176), Expect = 6e-13
Identities = 62/244 (25%), Positives = 99/244 (40%), Gaps = 16/244 (6%)
Query: 98 EMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMG--LDLRPHNHLQHYDMLKDMW 155
E Y+ +W + + + V A R+YA GG DL ++ YD + + W
Sbjct: 360 EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLAT---VESYDPVTNTW 416
Query: 156 VSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFS 215
M T R +Y GG +N+ E +D T +WT + +R +
Sbjct: 417 QPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYV 476
Query: 216 SFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGS 275
TLD +LY++GG Y L T++ ++ + W + + RR+
Sbjct: 477 RVATLDGNLYAVGG------YDSSSHLATVEKYEPQVNVWSPVAS---MLSRRSSAGVAV 527
Query: 276 LSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVN 335
L G + VAGG + + L + E + P WE + M R + + L AVGG N
Sbjct: 528 LEGALYVAGG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG-N 585
Query: 336 QGLS 339
G S
Sbjct: 586 DGSS 589
Score = 65.1 bits (157), Expect = 9e-11
Identities = 54/211 (25%), Positives = 85/211 (40%), Gaps = 12/211 (5%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
++A GG L H + YD D W +A M T R G+++Y +GG
Sbjct: 344 LFAVGGGSL-FAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD 402
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+ E +D T +W ++ +R+ L LYS GG Y L + + +
Sbjct: 403 LATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG------YDGASCLNSAERY 456
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D G W + + RR +L G + GG + + L T E + P N W
Sbjct: 457 DPLTGTWTSVAA---MSTRRRYVRVATLDGNLYAVGGY-DSSSHLATVEKYEPQVNVWSP 512
Query: 309 LPAMPTPRCACSSIVVKNCLLAVGGVNQGLS 339
+ +M + R + V++ L GG N G S
Sbjct: 513 VASMLSRRSSAGVAVLEGALYVAGG-NDGTS 542
Score = 62.4 bits (150), Expect = 6e-10
Identities = 45/192 (23%), Positives = 74/192 (38%), Gaps = 3/192 (1%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARA 70
W+ + +RR + G +Y+ GG D ++ E Y P WT++ + T R
Sbjct: 416 WQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASC-LNSAERYDPLTGTWTSVAAMSTRRR 474
Query: 71 GVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVY 130
V V L + +GG ++ L VE Y W + + V + +Y
Sbjct: 475 YVRVATLDGNLYAVGGYDSSS-HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALY 533
Query: 131 AAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVN 190
AGG N ++ Y W S+APM R +Y +GG ++N
Sbjct: 534 VAGGND-GTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLN 592
Query: 191 AFEVFDIETRSW 202
+ E ++ T W
Sbjct: 593 SIEKYNPRTNKW 604
Score = 43.5 bits (101), Expect = 3e-04
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARA 70
W+ +AP+ RR L+ G +YA+GG +D ++ E Y+P ++W A + T R+
Sbjct: 557 WESVAPMNIRRSTHDLVAMDGWLYAVGG-NDGSSSLNSIEKYNPRTNKWVAASCMFTRRS 615
Query: 71 GVAVTAL 77
V V L
Sbjct: 616 SVGVAVL 622
Score = 33.1 bits (74), Expect = 0.38
Identities = 21/64 (32%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Query: 277 SGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQ 336
+G V+ A G G+ + EA+ ++W ++ +M T R V N L AVGG +
Sbjct: 340 AGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYD- 398
Query: 337 GLSD 340
G SD
Sbjct: 399 GTSD 402
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 88.2 bits (217), Expect = 1e-17
Identities = 57/230 (24%), Positives = 105/230 (45%), Gaps = 3/230 (1%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E + K+ +W ++A LPSRR ++ G V+A+GG + + + + + Y P DQWT
Sbjct: 235 VECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS-LRVRTVDSYDPVKDQWT 293
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
++ + R+ + L + +GG L VE YNI +W + + +
Sbjct: 294 SVANMRDRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
Query: 121 SVTAKDYRVYAAGGM-GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
V +YA GG G + + ++ Y+ + W +A M T R A + + +Y
Sbjct: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 412
Query: 180 LGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGG 229
+GG + EV+D T +W + ++ R + ++ LY +GG
Sbjct: 413 VGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 462
Score = 71.2 bits (173), Expect = 1e-12
Identities = 59/257 (22%), Positives = 105/257 (40%), Gaps = 11/257 (4%)
Query: 77 LGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMG 136
L K ++V+GG + + VE Y+ E +W + + L + V+A GG
Sbjct: 217 LPKLMVVVGGQAPKAI--RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 274
Query: 137 LDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFD 196
LR + YD +KD W S+A M R + + +Y +GG +++ E ++
Sbjct: 275 GSLRVRT-VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYN 333
Query: 197 IETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWL 256
I++ W + +R+ + LY++GG + L T++ ++ W
Sbjct: 334 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA----SRQCLSTVECYNATTNEWT 389
Query: 257 KMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPR 316
+ + RR+ G L+ + GG + P V ++ E + P N W + M R
Sbjct: 390 YIAE---MSTRRSGAGVGVLNNLLYAVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCR 445
Query: 317 CACSSIVVKNCLLAVGG 333
V L VGG
Sbjct: 446 RNAGVCAVNGLLYVVGG 462
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/199 (26%), Positives = 87/199 (43%), Gaps = 4/199 (2%)
Query: 6 VKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRL 65
VKD QW +A + RR G +YA+GG D + + E Y+ ++++W + +
Sbjct: 288 VKD-QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS-TGLSSVEAYNIKSNEWFHVAPM 345
Query: 66 PTARAGVAVTALGKRIMVIGGV-GTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
T R+ V V +G + +GG G ++ L VE YN +W + + G V
Sbjct: 346 NTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGV 405
Query: 125 KDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQ 184
+ +YA GG L ++ YD + W +A M R A +YV+GG
Sbjct: 406 LNNLLYAVGGHDGPL-VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD 464
Query: 185 SKYAVNAFEVFDIETRSWT 203
+ + E ++ T WT
Sbjct: 465 GSCNLASVEYYNPTTDKWT 483
Score = 38.1 bits (87), Expect = 0.012
Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 2/70 (2%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPR-LPTAR 69
W+++A + R + G +Y +GG DD + E Y+P D+WT + + T R
Sbjct: 435 WRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMSTGR 493
Query: 70 AGVAVTALGK 79
+ VT + K
Sbjct: 494 SYAGVTVIDK 503
Score = 33.5 bits (75), Expect = 0.29
Identities = 15/59 (25%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 280 VIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGL 338
++V GG P + + E + + +W + +P+ RC + + + AVGG N L
Sbjct: 221 MVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSL 277
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 88.2 bits (217), Expect = 1e-17
Identities = 57/230 (24%), Positives = 105/230 (45%), Gaps = 3/230 (1%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E + K+ +W ++A LPSRR ++ G V+A+GG + + + + + Y P DQWT
Sbjct: 327 VECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS-LRVRTVDSYDPVKDQWT 385
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
++ + R+ + L + +GG L VE YNI +W + + +
Sbjct: 386 SVANMRDRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 444
Query: 121 SVTAKDYRVYAAGGM-GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
V +YA GG G + + ++ Y+ + W +A M T R A + + +Y
Sbjct: 445 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 504
Query: 180 LGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGG 229
+GG + EV+D T +W + ++ R + ++ LY +GG
Sbjct: 505 VGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 554
Score = 71.2 bits (173), Expect = 1e-12
Identities = 59/257 (22%), Positives = 105/257 (40%), Gaps = 11/257 (4%)
Query: 77 LGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMG 136
L K ++V+GG + + VE Y+ E +W + + L + V+A GG
Sbjct: 309 LPKLMVVVGGQAPKAI--RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 366
Query: 137 LDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFD 196
LR + YD +KD W S+A M R + + +Y +GG +++ E ++
Sbjct: 367 GSLRVRT-VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYN 425
Query: 197 IETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWL 256
I++ W + +R+ + LY++GG + L T++ ++ W
Sbjct: 426 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA----SRQCLSTVECYNATTNEWT 481
Query: 257 KMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPR 316
+ + RR+ G L+ + GG + P V ++ E + P N W + M R
Sbjct: 482 YIAE---MSTRRSGAGVGVLNNLLYAVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCR 537
Query: 317 CACSSIVVKNCLLAVGG 333
V L VGG
Sbjct: 538 RNAGVCAVNGLLYVVGG 554
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/199 (26%), Positives = 87/199 (43%), Gaps = 4/199 (2%)
Query: 6 VKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRL 65
VKD QW +A + RR G +YA+GG D + + E Y+ ++++W + +
Sbjct: 380 VKD-QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS-TGLSSVEAYNIKSNEWFHVAPM 437
Query: 66 PTARAGVAVTALGKRIMVIGGV-GTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
T R+ V V +G + +GG G ++ L VE YN +W + + G V
Sbjct: 438 NTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGV 497
Query: 125 KDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQ 184
+ +YA GG L ++ YD + W +A M R A +YV+GG
Sbjct: 498 LNNLLYAVGGHDGPL-VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD 556
Query: 185 SKYAVNAFEVFDIETRSWT 203
+ + E ++ T WT
Sbjct: 557 GSCNLASVEYYNPTTDKWT 575
Score = 38.1 bits (87), Expect = 0.012
Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 2/70 (2%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPR-LPTAR 69
W+++A + R + G +Y +GG DD + E Y+P D+WT + + T R
Sbjct: 527 WRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMSTGR 585
Query: 70 AGVAVTALGK 79
+ VT + K
Sbjct: 586 SYAGVTVIDK 595
Score = 33.5 bits (75), Expect = 0.29
Identities = 15/59 (25%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 280 VIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGL 338
++V GG P + + E + + +W + +P+ RC + + + AVGG N L
Sbjct: 313 MVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSL 369
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 88.2 bits (217), Expect = 1e-17
Identities = 57/230 (24%), Positives = 105/230 (45%), Gaps = 3/230 (1%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E + K+ +W ++A LPSRR ++ G V+A+GG + + + + + Y P DQWT
Sbjct: 323 VECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS-LRVRTVDSYDPVKDQWT 381
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
++ + R+ + L + +GG L VE YNI +W + + +
Sbjct: 382 SVANMRDRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 440
Query: 121 SVTAKDYRVYAAGGM-GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
V +YA GG G + + ++ Y+ + W +A M T R A + + +Y
Sbjct: 441 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 500
Query: 180 LGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGG 229
+GG + EV+D T +W + ++ R + ++ LY +GG
Sbjct: 501 VGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 550
Score = 71.2 bits (173), Expect = 1e-12
Identities = 59/257 (22%), Positives = 105/257 (40%), Gaps = 11/257 (4%)
Query: 77 LGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMG 136
L K ++V+GG + + VE Y+ E +W + + L + V+A GG
Sbjct: 305 LPKLMVVVGGQAPKAI--RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 362
Query: 137 LDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFD 196
LR + YD +KD W S+A M R + + +Y +GG +++ E ++
Sbjct: 363 GSLRVRT-VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYN 421
Query: 197 IETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWL 256
I++ W + +R+ + LY++GG + L T++ ++ W
Sbjct: 422 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA----SRQCLSTVECYNATTNEWT 477
Query: 257 KMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPR 316
+ + RR+ G L+ + GG + P V ++ E + P N W + M R
Sbjct: 478 YIAE---MSTRRSGAGVGVLNNLLYAVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCR 533
Query: 317 CACSSIVVKNCLLAVGG 333
V L VGG
Sbjct: 534 RNAGVCAVNGLLYVVGG 550
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/199 (26%), Positives = 87/199 (43%), Gaps = 4/199 (2%)
Query: 6 VKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRL 65
VKD QW +A + RR G +YA+GG D + + E Y+ ++++W + +
Sbjct: 376 VKD-QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS-TGLSSVEAYNIKSNEWFHVAPM 433
Query: 66 PTARAGVAVTALGKRIMVIGGV-GTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
T R+ V V +G + +GG G ++ L VE YN +W + + G V
Sbjct: 434 NTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGV 493
Query: 125 KDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQ 184
+ +YA GG L ++ YD + W +A M R A +YV+GG
Sbjct: 494 LNNLLYAVGGHDGPL-VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD 552
Query: 185 SKYAVNAFEVFDIETRSWT 203
+ + E ++ T WT
Sbjct: 553 GSCNLASVEYYNPTTDKWT 571
Score = 38.1 bits (87), Expect = 0.012
Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 2/70 (2%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPR-LPTAR 69
W+++A + R + G +Y +GG DD + E Y+P D+WT + + T R
Sbjct: 523 WRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMSTGR 581
Query: 70 AGVAVTALGK 79
+ VT + K
Sbjct: 582 SYAGVTVIDK 591
Score = 33.5 bits (75), Expect = 0.29
Identities = 15/59 (25%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 280 VIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGL 338
++V GG P + + E + + +W + +P+ RC + + + AVGG N L
Sbjct: 309 MVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSL 365
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 87.4 bits (215), Expect = 2e-17
Identities = 65/263 (24%), Positives = 110/263 (41%), Gaps = 11/263 (4%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGG---CDDNGVPMDCFEVYSPEAD 57
+E N D W RLA L R + GG +YA+GG D + Y+P +
Sbjct: 342 LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTN 401
Query: 58 QWTALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAA 117
QW+ + R + V + I +GG + VE Y + +W + +
Sbjct: 402 QWSPCAPMSVPRNRIGVGVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Query: 118 MGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKI 177
+G+ V + +YA GG R N + Y ++ W + M T R A + + I
Sbjct: 461 IGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCI 519
Query: 178 YVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYR 237
Y GG + +N+ E +D+ET +WT + ++R+ +Y LGG Y
Sbjct: 520 YAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG------YD 573
Query: 238 QPKFLRTMDVFDMEQGGWLKMER 260
FL +++ +D + W ++ R
Sbjct: 574 GHTFLDSVECYDPDTDTWSEVTR 596
Score = 86.7 bits (213), Expect = 3e-17
Identities = 71/302 (23%), Positives = 122/302 (40%), Gaps = 16/302 (5%)
Query: 18 PSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTAL 77
P++ + C + G +Y GG + E Y+P W L L R+G+A +
Sbjct: 313 PTQVMPCRAPKVGRLIYTAGGYFRQS--LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVV 370
Query: 78 GKRIMVIGGVGTN---QLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGG 134
G + +GG + ++ YN +W + + I V D +YA GG
Sbjct: 371 GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG 430
Query: 135 MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEV 194
+ HN ++ Y+ +D W +APM T R + +Y +GG +N+ E
Sbjct: 431 SHGCIH-HNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
Query: 195 FDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGG 254
+ E W + R+ + L N +Y+ GG Y L +++ +D+E
Sbjct: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG------YDGQDQLNSVERYDVETET 543
Query: 255 WLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPT 314
W + +K RR+ GR+ V GG T L++ E + P + W + M +
Sbjct: 544 WTFVAP---MKHRRSALGITVHQGRIYVLGGYDGH-TFLDSVECYDPDTDTWSEVTRMTS 599
Query: 315 PR 316
R
Sbjct: 600 GR 601
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/209 (23%), Positives = 94/209 (44%), Gaps = 16/209 (7%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
+Y AGG + ++L+ Y+ W+ LA + PR + G +Y +GGR +
Sbjct: 328 IYTAGGYFR--QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 189 VN----AFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRT 244
N A + ++ T W+ + R +D H+Y++GG G ++ +
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG-SHGCIHHN-----S 439
Query: 245 MDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKN 304
++ ++ E+ W + R V ++ R++ A G + L +AE ++P +N
Sbjct: 440 VERYEPERDEWHLVAPML----TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERN 495
Query: 305 KWEILPAMPTPRCACSSIVVKNCLLAVGG 333
+W ++ AM T R V+ NC+ A GG
Sbjct: 496 EWRMITAMNTIRSGAGVCVLHNCIYAAGG 524
Score = 46.6 bits (109), Expect = 3e-05
Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 1/70 (1%)
Query: 5 NVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPR 64
+V+ W +AP+ RR + G++Y +GG D + +D E Y P+ D W+ + R
Sbjct: 538 DVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF-LDSVECYDPDTDTWSEVTR 596
Query: 65 LPTARAGVAV 74
+ + R+GV V
Sbjct: 597 MTSGRSGVGV 606
Score = 33.1 bits (74), Expect = 0.38
Identities = 23/59 (38%), Positives = 28/59 (47%), Gaps = 3/59 (5%)
Query: 278 GRVI-VAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVN 335
GR+I AGG Q L EA++P W L + PR + VV L AVGG N
Sbjct: 325 GRLIYTAGGYFRQS--LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN 381
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 87.4 bits (215), Expect = 2e-17
Identities = 65/263 (24%), Positives = 110/263 (41%), Gaps = 11/263 (4%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGG---CDDNGVPMDCFEVYSPEAD 57
+E N D W RLA L R + GG +YA+GG D + Y+P +
Sbjct: 342 LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTN 401
Query: 58 QWTALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAA 117
QW+ + R + V + I +GG + VE Y + +W + +
Sbjct: 402 QWSPCAPMSVPRNRIGVGVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Query: 118 MGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKI 177
+G+ V + +YA GG R N + Y ++ W + M T R A + + I
Sbjct: 461 IGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCI 519
Query: 178 YVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYR 237
Y GG + +N+ E +D+ET +WT + ++R+ +Y LGG Y
Sbjct: 520 YAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG------YD 573
Query: 238 QPKFLRTMDVFDMEQGGWLKMER 260
FL +++ +D + W ++ R
Sbjct: 574 GHTFLDSVECYDPDTDTWSEVTR 596
Score = 86.7 bits (213), Expect = 3e-17
Identities = 71/302 (23%), Positives = 122/302 (40%), Gaps = 16/302 (5%)
Query: 18 PSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTAL 77
P++ + C + G +Y GG + E Y+P W L L R+G+A +
Sbjct: 313 PTQVMPCRAPKVGRLIYTAGGYFRQS--LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVV 370
Query: 78 GKRIMVIGGVGTN---QLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGG 134
G + +GG + ++ YN +W + + I V D +YA GG
Sbjct: 371 GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG 430
Query: 135 MGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEV 194
+ HN ++ Y+ +D W +APM T R + +Y +GG +N+ E
Sbjct: 431 SHGCIH-HNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
Query: 195 FDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGG 254
+ E W + R+ + L N +Y+ GG Y L +++ +D+E
Sbjct: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG------YDGQDQLNSVERYDVETET 543
Query: 255 WLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPT 314
W + +K RR+ GR+ V GG T L++ E + P + W + M +
Sbjct: 544 WTFVAP---MKHRRSALGITVHQGRIYVLGGYDGH-TFLDSVECYDPDTDTWSEVTRMTS 599
Query: 315 PR 316
R
Sbjct: 600 GR 601
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/209 (23%), Positives = 94/209 (44%), Gaps = 16/209 (7%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
+Y AGG + ++L+ Y+ W+ LA + PR + G +Y +GGR +
Sbjct: 328 IYTAGGYFR--QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 189 VN----AFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRT 244
N A + ++ T W+ + R +D H+Y++GG G ++ +
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG-SHGCIHHN-----S 439
Query: 245 MDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKN 304
++ ++ E+ W + R V ++ R++ A G + L +AE ++P +N
Sbjct: 440 VERYEPERDEWHLVAPML----TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERN 495
Query: 305 KWEILPAMPTPRCACSSIVVKNCLLAVGG 333
+W ++ AM T R V+ NC+ A GG
Sbjct: 496 EWRMITAMNTIRSGAGVCVLHNCIYAAGG 524
Score = 46.6 bits (109), Expect = 3e-05
Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 1/70 (1%)
Query: 5 NVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPR 64
+V+ W +AP+ RR + G++Y +GG D + +D E Y P+ D W+ + R
Sbjct: 538 DVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF-LDSVECYDPDTDTWSEVTR 596
Query: 65 LPTARAGVAV 74
+ + R+GV V
Sbjct: 597 MTSGRSGVGV 606
Score = 33.1 bits (74), Expect = 0.38
Identities = 23/59 (38%), Positives = 28/59 (47%), Gaps = 3/59 (5%)
Query: 278 GRVI-VAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVN 335
GR+I AGG Q L EA++P W L + PR + VV L AVGG N
Sbjct: 325 GRLIYTAGGYFRQS--LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN 381
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 87.0 bits (214), Expect = 2e-17
Identities = 56/192 (29%), Positives = 90/192 (46%), Gaps = 3/192 (1%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARA 70
W ++AP+ SRR Y S+ G +YA+GG D V ++ E Y PE +QWT + + R+
Sbjct: 366 WHQVAPMHSRRCYVSVTVLGNFIYAMGGF-DGYVRLNTAERYEPETNQWTLIAPMHEQRS 424
Query: 71 GVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVY 130
+ T L ++ + GG N+ L E+YN + +W + +R GI V A VY
Sbjct: 425 DASATTLYGKVYICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVY 483
Query: 131 AAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVN 190
A GG R + + Y + + W ++ M PR + ++V+GG
Sbjct: 484 AVGGFDGANRLRS-AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTF 542
Query: 191 AFEVFDIETRSW 202
E +D +T W
Sbjct: 543 NVECYDEKTDEW 554
Score = 83.2 bits (204), Expect = 3e-16
Identities = 69/257 (26%), Positives = 109/257 (42%), Gaps = 15/257 (5%)
Query: 81 IMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA--KDYRVYAAGGMGLD 138
+ IGG P +E Y+ +W + E+ A K Y VY GG
Sbjct: 293 LFAIGGWSGGS-PTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGY-VYIIGGFD-S 349
Query: 139 LRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIE 198
+ N ++ +D +K W +APM + R + + G+ IY +GG +N E ++ E
Sbjct: 350 VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPE 409
Query: 199 TRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKM 258
T WT + +R+ +S TL +Y GG + + L T +V++ E W +
Sbjct: 410 TNQWTLIAPMHEQRSDASATTLYGKVYICGG------FNGNECLFTAEVYNTESNQWTVI 463
Query: 259 ERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCA 318
++ RR+ + V GG + L +AEA+ P N W +P M PR
Sbjct: 464 AP---MRSRRSGIGVIAYGEHVYAVGGF-DGANRLRSAEAYSPVANTWRTIPTMFNPRSN 519
Query: 319 CSSIVVKNCLLAVGGVN 335
VV + L VGG N
Sbjct: 520 FGIEVVDDLLFVVGGFN 536
Score = 75.1 bits (183), Expect = 9e-14
Identities = 71/295 (24%), Positives = 119/295 (40%), Gaps = 18/295 (6%)
Query: 33 VYAIGGCDDNGVPMDCFEVYSPEADQW---TALPRLPTARAGVAVTALGKRIMVIGGVGT 89
++AIGG G P + E Y AD+W T P A G A L + +IGG +
Sbjct: 293 LFAIGGWS-GGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAY--LKGYVYIIGGFDS 349
Query: 90 NQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYD 149
V+ ++ + W + + + +SVT +YA GG +R N + Y+
Sbjct: 350 VDY-FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVR-LNTAERYE 407
Query: 150 MLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIP 209
+ W +APM R A++ K+Y+ GG + EV++ E+ WT +
Sbjct: 408 PETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMR 467
Query: 210 YKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRA 269
+R+ + H+Y++GG + LR+ + + W + F R+
Sbjct: 468 SRRSGIGVIAYGEHVYAVGG------FDGANRLRSAEAYSPVANTWRTIPTMF---NPRS 518
Query: 270 DFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVV 324
+F + + V GG N T E + ++W M R A S VV
Sbjct: 519 NFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
Score = 62.0 bits (149), Expect = 8e-10
Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 11/162 (6%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCF---EVYSPEADQWTALPRLP 66
QW +AP+ +R S G+VY GG + N +C EVY+ E++QWT + +
Sbjct: 412 QWTLIAPMHEQRSDASATTLYGKVYICGGFNGN----ECLFTAEVYNTESNQWTVIAPMR 467
Query: 67 TARAGVAVTALGKRIMVIGGV-GTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAK 125
+ R+G+ V A G+ + +GG G N+ L+ E Y+ W+ + +
Sbjct: 468 SRRSGIGVIAYGEHVYAVGGFDGANR--LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVV 525
Query: 126 DYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYA 167
D ++ GG N ++ YD D W M R A
Sbjct: 526 DDLLFVVGGFNGFTTTFN-VECYDEKTDEWYDAHDMSIYRSA 566
Score = 53.5 bits (127), Expect = 3e-07
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 2/106 (1%)
Query: 2 EVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTA 61
EV N + QW +AP+ SRR ++ G VYA+GG D + E YSP A+ W
Sbjct: 451 EVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGF-DGANRLRSAEAYSPVANTWRT 509
Query: 62 LPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKW 107
+P + R+ + + + V+GG VE Y+ +W
Sbjct: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFN-VECYDEKTDEW 554
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 86.7 bits (213), Expect = 3e-17
Identities = 55/230 (23%), Positives = 106/230 (46%), Gaps = 3/230 (1%)
Query: 1 MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT 60
+E + ++ +W ++A LPSRR ++ G VYA+GG + + + + +VY DQWT
Sbjct: 317 VECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGS-LRVRTVDVYDGVKDQWT 375
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
++ + R+ + L + +GG L VE Y+ +W + + +
Sbjct: 376 SIASMQERRSTLGAAVLNDLLYAVGGFD-GSTGLASVEAYSYKTNEWFFVAPMNTRRSSV 434
Query: 121 SVTAKDYRVYAAGGM-GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
V + ++YA GG G + + ++ Y+ + W+ +A M T R A + ++Y
Sbjct: 435 GVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYA 494
Query: 180 LGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGG 229
GG + EV+D T +W + ++ R + ++ LY +GG
Sbjct: 495 TGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG 544
Score = 83.2 bits (204), Expect = 3e-16
Identities = 64/258 (24%), Positives = 110/258 (42%), Gaps = 11/258 (4%)
Query: 76 ALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGM 135
+L K ++V+GG + + VE Y+ +E +W + + L V VYA GG
Sbjct: 298 SLPKVMIVVGGQAPKAI--RSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF 355
Query: 136 GLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVF 195
LR + YD +KD W S+A M R + + +Y +GG + + E +
Sbjct: 356 NGSLRVRT-VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAY 414
Query: 196 DIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGW 255
+T W + +R+ ++ LY++GG + L T++ ++ W
Sbjct: 415 SYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA----SRQCLSTVEQYNPATNEW 470
Query: 256 LKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTP 315
+ + + RR+ G LSG++ GG + P V ++ E + PG N W+ + M
Sbjct: 471 IYVAD---MSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEVYDPGTNTWKQVADMNMC 526
Query: 316 RCACSSIVVKNCLLAVGG 333
R V L VGG
Sbjct: 527 RRNAGVCAVNGLLYVVGG 544
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/282 (23%), Positives = 123/282 (43%), Gaps = 15/282 (5%)
Query: 50 EVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKK 109
E Y E D+W + LP+ R V + + +GG L ++ V++Y+ + +W
Sbjct: 318 ECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFN-GSLRVRTVDVYDGVKDQWTS 376
Query: 110 RSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAAT 169
+ ++E + + +YA GG + ++ Y + W +APM T R +
Sbjct: 377 IASMQERRSTLGAAVLNDLLYAVGGFDGSTGLAS-VEAYSYKTNEWFFVAPMNTRRSSVG 435
Query: 170 SFLRGSKIYVLGGRQ--SKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSL 227
+ K+Y +GG S+ ++ E ++ T W ++ +R+ + L LY+
Sbjct: 436 VGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYAT 495
Query: 228 GGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLG 287
GG G L R ++++V+D W K + +R A A ++G + V GG
Sbjct: 496 GG-HDGPLVR-----KSVEVYDPGTNTW-KQVADMNMCRRNAGVCA--VNGLLYVVGG-D 545
Query: 288 NQPTVLETAEAFHPGKNKWEILPA-MPTPRCACSSIVVKNCL 328
+ L + E ++P +KW +LP M T R V+ L
Sbjct: 546 DGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/221 (25%), Positives = 94/221 (42%), Gaps = 5/221 (2%)
Query: 6 VKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRL 65
VKD QW +A + RR +YA+GG D + + E YS + ++W + +
Sbjct: 370 VKD-QWTSIASMQERRSTLGAAVLNDLLYAVGGFDGS-TGLASVEAYSYKTNEWFFVAPM 427
Query: 66 PTARAGVAVTALGKRIMVIGGV-GTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
T R+ V V + ++ +GG G ++ L VE YN +W + + G V
Sbjct: 428 NTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGV 487
Query: 125 KDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQ 184
++YA GG L ++ YD + W +A M R A +YV+GG
Sbjct: 488 LSGQLYATGGHDGPL-VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDD 546
Query: 185 SKYAVNAFEVFDIETRSWTKFP-NIPYKRAFSSFVTLDNHL 224
+ + E ++ T WT P N+ R+++ + L
Sbjct: 547 GSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 34.7 bits (78), Expect = 0.13
Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 2/64 (3%)
Query: 275 SLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGV 334
SL +IV GG P + + E + +++W+ + +P+ RC + + + AVGG
Sbjct: 298 SLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF 355
Query: 335 NQGL 338
N L
Sbjct: 356 NGSL 359
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 85.9 bits (211), Expect = 5e-17
Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 11/217 (5%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARA 70
W + P+ + R + G +YA+GG D ++ E + PE QW + + T R+
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDPEGRQWNYVASMSTPRS 561
Query: 71 GVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVY 130
V V AL ++ IGG + LK +E ++ KW + + + G+ V + +Y
Sbjct: 562 TVGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
Query: 131 AAGGMGLDLRPHNH-------LQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGR 183
GG D NH ++ YD D W ++AP+ PR A G K+YV+GG
Sbjct: 621 VVGGH--DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
Query: 184 QSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
+N E +D + W + + RA + V +
Sbjct: 679 DGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715
Score = 74.7 bits (182), Expect = 1e-13
Identities = 68/297 (22%), Positives = 111/297 (37%), Gaps = 7/297 (2%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G +YA+GG D E Y + W + + R V + ++ V+GG
Sbjct: 427 TVGALYAVGGMDAMK-GTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-R 484
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
L VE +N W + G+ V + +YA GG N ++ +
Sbjct: 485 DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD-GWSYLNTVERW 543
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D W +A M TPR +K+Y +GGR + + E FD T W+ +
Sbjct: 544 DPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPM 603
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+R T + LY +GG + ++ +D + W + L R
Sbjct: 604 SKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAP---LSVPR 660
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVK 325
L ++ V GG T L T E++ +N+W+ + R +VVK
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGH-TYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVK 716
Score = 72.4 bits (176), Expect = 6e-13
Identities = 56/242 (23%), Positives = 99/242 (40%), Gaps = 15/242 (6%)
Query: 97 VEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWV 156
+E Y++ W + + V D ++Y GG L+ N ++ ++ + +W
Sbjct: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRD-GLKTLNTVECFNPVGKIWT 504
Query: 157 SLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSS 216
+ PM T R+ +Y +GG +N E +D E R W ++ R+
Sbjct: 505 VMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVG 564
Query: 217 FVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSL 276
V L+N LY++GG R G L++M+ FD W + KRR +
Sbjct: 565 VVALNNKLYAIGG-RDGS-----SCLKSMEYFDPHTNKWSLCAP---MSKRRGGVGVATY 615
Query: 277 SGRVIVAGG-----LGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAV 331
+G + V GG + + + E + P + W + + PR A + + + L V
Sbjct: 616 NGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVV 675
Query: 332 GG 333
GG
Sbjct: 676 GG 677
Score = 65.5 bits (158), Expect = 7e-11
Identities = 55/222 (24%), Positives = 93/222 (41%), Gaps = 18/222 (8%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
+YA GGM ++ ++ YD+ + W+ + M R + +K+YV+GGR
Sbjct: 431 LYAVGGMDA-MKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+N E F+ + WT P + R TL+ +Y++GG + +L T++ +
Sbjct: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG------HDGWSYLNTVERW 543
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D E W + + R+ +L+ ++ GG + L++ E F P NKW +
Sbjct: 544 DPEGRQWNYVAS---MSTPRSTVGVVALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSL 599
Query: 309 LPAMPTPRCACSSIVVKNCLLAVGGVN-------QGLSDAVE 343
M R L VGG + LSD VE
Sbjct: 600 CAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVE 641
Score = 60.1 bits (144), Expect = 3e-09
Identities = 46/173 (26%), Positives = 71/173 (41%), Gaps = 11/173 (6%)
Query: 161 MPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
M +PR G+ +Y +GG + E +D+ T SW + +R +
Sbjct: 416 MQSPRTKPRKSTVGA-LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 221 DNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRV 280
DN LY +GG R G K L T++ F+ W M + R +L G +
Sbjct: 475 DNKLYVVGG-RDGL-----KTLNTVECFNPVGKIWTVMPP---MSTHRHGLGVATLEGPM 525
Query: 281 IVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
GG + L T E + P +W + +M TPR + + N L A+GG
Sbjct: 526 YAVGGHDGW-SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
Score = 45.8 bits (107), Expect = 6e-05
Identities = 38/165 (23%), Positives = 67/165 (40%), Gaps = 9/165 (5%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTAR 69
QW +A + + R ++ ++YAIGG D + + E + P ++W+ + R
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRR 607
Query: 70 AGVAVTALGKRIMVIGG---VGTNQLP--LKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
GV V + V+GG +N VE Y+ W + L ++V
Sbjct: 608 GGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCP 667
Query: 125 KDYRVYAAGGMGLDLRPH-NHLQHYDMLKDMWVSLAPMPTPRYAA 168
++Y G G D + N ++ YD ++ W P+ R A
Sbjct: 668 LGDKLYVVG--GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGA 710
Score = 32.3 bits (72), Expect = 0.65
Identities = 18/71 (25%), Positives = 32/71 (45%), Gaps = 1/71 (1%)
Query: 7 KDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLP 66
K W +APL R ++ G ++Y +GG D + ++ E Y + ++W +
Sbjct: 646 KGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGH-TYLNTVESYDAQRNEWKEEVPVN 704
Query: 67 TARAGVAVTAL 77
RAG V +
Sbjct: 705 IGRAGACVVVV 715
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 85.5 bits (210), Expect = 6e-17
Identities = 55/199 (27%), Positives = 89/199 (44%), Gaps = 11/199 (5%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARA 70
W + P+ + R + G +YA+GG D ++ E + PE QW + + T R+
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDPEGRQWNYVASMSTPRS 561
Query: 71 GVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVY 130
V V AL ++ IGG + LK +E ++ KW + + + G+ V + +Y
Sbjct: 562 TVGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
Query: 131 AAGGMGLDLRPHNH-------LQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGR 183
GG D NH ++ YD D W ++AP+ PR A G K+YV+GG
Sbjct: 621 VVGGH--DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
Query: 184 QSKYAVNAFEVFDIETRSW 202
+N E +D + W
Sbjct: 679 DGHTYLNTVESYDAQRNEW 697
Score = 72.8 bits (177), Expect = 4e-13
Identities = 64/279 (22%), Positives = 105/279 (37%), Gaps = 7/279 (2%)
Query: 29 TGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVG 88
T G +YA+GG D E Y + W + + R V + ++ V+GG
Sbjct: 427 TVGALYAVGGMDAMK-GTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-R 484
Query: 89 TNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHY 148
L VE +N W + G+ V + +YA GG N ++ +
Sbjct: 485 DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD-GWSYLNTVERW 543
Query: 149 DMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNI 208
D W +A M TPR +K+Y +GGR + + E FD T W+ +
Sbjct: 544 DPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPM 603
Query: 209 PYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRR 268
+R T + LY +GG + ++ +D + W + L R
Sbjct: 604 SKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAP---LSVPR 660
Query: 269 ADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWE 307
L ++ V GG T L T E++ +N+W+
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGH-TYLNTVESYDAQRNEWK 698
Score = 72.4 bits (176), Expect = 6e-13
Identities = 56/242 (23%), Positives = 99/242 (40%), Gaps = 15/242 (6%)
Query: 97 VEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWV 156
+E Y++ W + + V D ++Y GG L+ N ++ ++ + +W
Sbjct: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRD-GLKTLNTVECFNPVGKIWT 504
Query: 157 SLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSS 216
+ PM T R+ +Y +GG +N E +D E R W ++ R+
Sbjct: 505 VMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVG 564
Query: 217 FVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSL 276
V L+N LY++GG R G L++M+ FD W + KRR +
Sbjct: 565 VVALNNKLYAIGG-RDGS-----SCLKSMEYFDPHTNKWSLCAP---MSKRRGGVGVATY 615
Query: 277 SGRVIVAGG-----LGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAV 331
+G + V GG + + + E + P + W + + PR A + + + L V
Sbjct: 616 NGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVV 675
Query: 332 GG 333
GG
Sbjct: 676 GG 677
Score = 65.5 bits (158), Expect = 7e-11
Identities = 55/222 (24%), Positives = 93/222 (41%), Gaps = 18/222 (8%)
Query: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
+YA GGM ++ ++ YD+ + W+ + M R + +K+YV+GGR
Sbjct: 431 LYAVGGMDA-MKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
Query: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 248
+N E F+ + WT P + R TL+ +Y++GG + +L T++ +
Sbjct: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG------HDGWSYLNTVERW 543
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D E W + + R+ +L+ ++ GG + L++ E F P NKW +
Sbjct: 544 DPEGRQWNYVAS---MSTPRSTVGVVALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSL 599
Query: 309 LPAMPTPRCACSSIVVKNCLLAVGGVN-------QGLSDAVE 343
M R L VGG + LSD VE
Sbjct: 600 CAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVE 641
Score = 60.1 bits (144), Expect = 3e-09
Identities = 46/173 (26%), Positives = 71/173 (41%), Gaps = 11/173 (6%)
Query: 161 MPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTL 220
M +PR G+ +Y +GG + E +D+ T SW + +R +
Sbjct: 416 MQSPRTKPRKSTVGA-LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 221 DNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRV 280
DN LY +GG R G K L T++ F+ W M + R +L G +
Sbjct: 475 DNKLYVVGG-RDGL-----KTLNTVECFNPVGKIWTVMPP---MSTHRHGLGVATLEGPM 525
Query: 281 IVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGG 333
GG + L T E + P +W + +M TPR + + N L A+GG
Sbjct: 526 YAVGGHDGW-SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
Score = 43.9 bits (102), Expect = 2e-04
Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 9/152 (5%)
Query: 10 QWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTAR 69
QW +A + + R ++ ++YAIGG D + + E + P ++W+ + R
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRR 607
Query: 70 AGVAVTALGKRIMVIGG---VGTNQLP--LKVVEMYNIDEGKWKKRSMLREAAMGISVTA 124
GV V + V+GG +N VE Y+ W + L ++V
Sbjct: 608 GGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCP 667
Query: 125 KDYRVYAAGGMGLDLRPH-NHLQHYDMLKDMW 155
++Y G G D + N ++ YD ++ W
Sbjct: 668 LGDKLYVVG--GYDGHTYLNTVESYDAQRNEW 697
Score = 28.9 bits (63), Expect = 7.2
Identities = 14/53 (26%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 7 KDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQW 59
K W +APL R ++ G ++Y +GG D + ++ E Y + ++W
Sbjct: 646 KGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGH-TYLNTVESYDAQRNEW 697
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/262 (25%), Positives = 107/262 (40%), Gaps = 16/262 (6%)
Query: 5 NVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGG--CDDNG--VPMDCFEVYSPEADQWT 60
+ K QW + PLP+RR + + GG ++ GG DNG + Y P QW
Sbjct: 319 DAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWI 378
Query: 61 ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI 120
+ + R + ++ ++ IGG N L VE Y+ W + L G
Sbjct: 379 KVASMNQRRVDFYLASIEDMLVAIGGRNENG-ALSSVETYSPKTDSWSYVAGLPRFTYGH 437
Query: 121 SVTAKDYRVYAAGGMGLDLRPH-NHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYV 179
+ T VY +GG + P+ +L YD D+W PM T R + G IY
Sbjct: 438 AGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYS 497
Query: 180 LGGRQSKY-AVNAFEVFDIETRS-----WTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQG 233
+GG ++ F+V +E S WT+ + + + S + +Y LGG
Sbjct: 498 IGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYS-- 555
Query: 234 RLYRQPKFLRTMDVFDMEQGGW 255
+ F +T+ V+D E W
Sbjct: 556 --WENTAFSKTVQVYDREADKW 575
Score = 62.0 bits (149), Expect = 8e-10
Identities = 37/115 (32%), Positives = 58/115 (50%), Gaps = 6/115 (5%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEV-----YSPEADQWTALPRL 65
W+ P+ + R + S+ G +Y+IGG DDN M+ F+V YSP+ +QWT + L
Sbjct: 473 WEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPL 532
Query: 66 PTARAGVAVTALGKRIMVIGGVG-TNQLPLKVVEMYNIDEGKWKKRSMLREAAMG 119
A + V RI ++GG N K V++Y+ + KW + L +A G
Sbjct: 533 LHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAG 587
Score = 40.0 bits (92), Expect = 0.003
Identities = 37/190 (19%), Positives = 71/190 (37%), Gaps = 27/190 (14%)
Query: 157 SLAPMPTPRYAATSFLRGS-KIYVLGGRQSKYAVNAFE---VFDIETRSWTKFPNIPYKR 212
+LA P + T+ ++ +GG S+ + + D ++ W K +P +R
Sbjct: 276 NLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARR 335
Query: 213 AFSSFVTLDNHLYSLGG---------LRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFF 263
+ L ++ GG LYR +D W+K+
Sbjct: 336 SHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYR----------YDPRCKQWIKVAS--- 382
Query: 264 LKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIV 323
+ +RR DF S+ ++ GG N+ L + E + P + W + +P + +
Sbjct: 383 MNQRRVDFYLASIEDMLVAIGG-RNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTI 441
Query: 324 VKNCLLAVGG 333
K+ + GG
Sbjct: 442 YKDFVYISGG 451
Score = 33.9 bits (76), Expect = 0.22
Identities = 20/88 (22%), Positives = 38/88 (43%), Gaps = 5/88 (5%)
Query: 147 HYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSK-----YAVNAFEVFDIETRS 201
+ D + WV P+P R + G I++ GG S+ A N +D +
Sbjct: 317 YLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQ 376
Query: 202 WTKFPNIPYKRAFSSFVTLDNHLYSLGG 229
W K ++ +R ++++ L ++GG
Sbjct: 377 WIKVASMNQRRVDFYLASIEDMLVAIGG 404
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 83.2 bits (204), Expect = 3e-16
Identities = 66/253 (26%), Positives = 104/253 (41%), Gaps = 16/253 (6%)
Query: 11 WKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVP-------MDCFEVYSPEADQWTALP 63
W LAPL R + +VY IGG N P + E ++P+ + WT+L
Sbjct: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
Query: 64 RLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVT 123
R+ +R+ + V L + +GG Q L+ VE Y KW+ + + +
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGY-DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAA 429
Query: 124 AKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGR 183
D +YA GG G N ++ YD KD W +A M R + I+V+GG
Sbjct: 430 VLDGMIYAIGGYG--PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH 487
Query: 184 QSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLR 243
+++ E +D WT + R +DN+LY +GG + +L
Sbjct: 488 NGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG------HSGSSYLN 541
Query: 244 TMDVFDMEQGGWL 256
T+ +D WL
Sbjct: 542 TVQKYDPISDTWL 554
Score = 82.4 bits (202), Expect = 5e-16
Identities = 62/262 (23%), Positives = 107/262 (40%), Gaps = 18/262 (6%)
Query: 79 KRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLD 138
K + +GG L VEMY W + L + D +VY GG+ +
Sbjct: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATN 342
Query: 139 LRP-------HNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNA 191
+RP N ++ ++ + W SL M R + ++Y LGG + + +
Sbjct: 343 VRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS 402
Query: 192 FEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDME 251
E + + R W + R+ + LD +Y++GG P + +++ +D
Sbjct: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYG-------PAHMNSVERYDPS 455
Query: 252 QGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPA 311
+ W E + +R F G + G + V GG N + L + E + P +N+W +
Sbjct: 456 KDSW---EMVASMADKRIHFGVGVMLGFIFVVGG-HNGVSHLSSIERYDPHQNQWTVCRP 511
Query: 312 MPTPRCACSSIVVKNCLLAVGG 333
M PR + V+ N L VGG
Sbjct: 512 MKEPRTGVGAAVIDNYLYVVGG 533
Score = 76.3 bits (186), Expect = 4e-14
Identities = 69/291 (23%), Positives = 114/291 (39%), Gaps = 21/291 (7%)
Query: 35 AIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVGTNQLP- 93
A+GG +D E+Y P+ D W L L R + L +++ VIGG+ TN P
Sbjct: 287 AVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPG 346
Query: 94 ------LKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPH-NHLQ 146
VE +N D W + E+ + V +YA G G D + + ++
Sbjct: 347 VTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALG--GYDGQSYLQSVE 404
Query: 147 HYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFP 206
Y W +APM T R + + IY +GG + +N+ E +D SW
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNSVERYDPSKDSWEMVA 463
Query: 207 NIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKK 266
++ KR + ++ +GG + L +++ +D Q W +K+
Sbjct: 464 SMADKRIHFGVGVMLGFIFVVGG------HNGVSHLSSIERYDPHQNQWTVCRP---MKE 514
Query: 267 RRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPRC 317
R A + + V GG + L T + + P + W M RC
Sbjct: 515 PRTGVGAAVIDNYLYVVGGHSGS-SYLNTVQKYDPISDTWLDSAGMIYCRC 564
Score = 73.2 bits (178), Expect = 3e-13
Identities = 51/199 (25%), Positives = 87/199 (43%), Gaps = 19/199 (9%)
Query: 145 LQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAV--------NAFEVFD 196
++ Y D W+ LAP+ PRY + K+YV+GG + N+ E ++
Sbjct: 301 VEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWN 360
Query: 197 IETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWL 256
+T +WT + R+ V L LY+LGG Y +L++++ + + W
Sbjct: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGG------YDGQSYLQSVEKYIPKIRKWQ 414
Query: 257 KMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEILPAMPTPR 316
+ + R+ F A L G + GG G P + + E + P K+ WE++ +M R
Sbjct: 415 PVAP---MTTTRSCFAAAVLDGMIYAIGGYG--PAHMNSVERYDPSKDSWEMVASMADKR 469
Query: 317 CACSSIVVKNCLLAVGGVN 335
V+ + VGG N
Sbjct: 470 IHFGVGVMLGFIFVVGGHN 488
Score = 58.5 bits (140), Expect = 8e-09
Identities = 41/159 (25%), Positives = 67/159 (42%), Gaps = 6/159 (3%)
Query: 3 VPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTAL 62
+P ++ +W+ +AP+ + R + G +YAIGG M+ E Y P D W +
Sbjct: 407 IPKIR--KWQPVAPMTTTRSCFAAAVLDGMIYAIGGY--GPAHMNSVERYDPSKDSWEMV 462
Query: 63 PRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISV 122
+ R V + I V+GG L +E Y+ + +W ++E G+
Sbjct: 463 ASMADKRIHFGVGVMLGFIFVVGG-HNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGA 521
Query: 123 TAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPM 161
D +Y GG N +Q YD + D W+ A M
Sbjct: 522 AVIDNYLYVVGGHS-GSSYLNTVQKYDPISDTWLDSAGM 559
Score = 50.4 bits (119), Expect = 2e-06
Identities = 39/169 (23%), Positives = 77/169 (45%), Gaps = 11/169 (6%)
Query: 180 LGGRQSKYA-VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGL----RQGR 234
+GG+ +A +++ E++ + SW + R LD +Y +GG+ R G
Sbjct: 288 VGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGV 347
Query: 235 LYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLE 294
R K +++ ++ + W +ER + + R+ L+G + GG Q + L+
Sbjct: 348 TIR--KHENSVECWNPDTNTWTSLER---MNESRSTLGVVVLAGELYALGGYDGQ-SYLQ 401
Query: 295 TAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVE 343
+ E + P KW+ + M T R ++ V+ + A+GG ++VE
Sbjct: 402 SVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVE 450
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 80.1 bits (196), Expect = 3e-15
Identities = 67/269 (24%), Positives = 115/269 (42%), Gaps = 24/269 (8%)
Query: 5 NVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGG-----------CDDNGVPMDCFEVYS 53
+V + +W+ L LP+ + S+ G ++ +GG DD+ V Y
Sbjct: 340 DVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYD 399
Query: 54 PEADQWTALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSML 113
P WT +P + ARA A+G+R++ +GG+G L VEMY++ +W L
Sbjct: 400 PRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGAL 459
Query: 114 REAAMGISVTAKDYR-VYAAGG-MGLDLRPHNHLQHYDML---KDMWVSLAPMPTPRYAA 168
A G + D VY +GG G + L+ +L + +W APM T R+
Sbjct: 460 PRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGH 519
Query: 169 TSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLG 228
+ ++ GR + + E +D WT+ +PY R ++ LG
Sbjct: 520 HMAVLRGAVFAFLGRYEPF--SEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLG 577
Query: 229 GLRQGRLYRQPKFLRTMDV--FDMEQGGW 255
GL+ +R + + T +V +D++ W
Sbjct: 578 GLK----WRDSRQVPTRNVVGYDLDLDRW 602
Score = 41.6 bits (96), Expect = 0.001
Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 9/125 (7%)
Query: 195 FDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQP----KFLRTMDV--F 248
FD+ W +P S T N L+ LGG P + T V +
Sbjct: 339 FDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRY 398
Query: 249 DMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNKWEI 308
D W ++ +++ RA F G++ R++ GGLG VL + E + +++W
Sbjct: 399 DPRFHAWTEVPA---MREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTA 455
Query: 309 LPAMP 313
A+P
Sbjct: 456 AGALP 460
Score = 41.2 bits (95), Expect = 0.001
Identities = 64/287 (22%), Positives = 97/287 (33%), Gaps = 47/287 (16%)
Query: 49 FEVYSPEADQWTALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWK 108
F+VY+ +W +L +LPT G +V G + V+GG +
Sbjct: 339 FDVYN---HRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPS------------------ 377
Query: 109 KRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAA 168
S A D RV A + YD W + M R
Sbjct: 378 --------GSASSPLADDSRVVTA-----------QVHRYDPRFHAWTEVPAMREARAHF 418
Query: 169 TSFLRGSKIYVLGGRQSKYAVNA-FEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSL 227
G ++ +GG + V A E++D+ WT +P + D + +
Sbjct: 419 WCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYI 478
Query: 228 GGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLG 287
G + GR LR + V E+ W K + R L G V LG
Sbjct: 479 SGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAP---MGTARFGHHMAVLRGAVFAF--LG 533
Query: 288 NQPTVLETAEAFHPGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGV 334
E E + PG ++W L +P R VV+ L +GG+
Sbjct: 534 RYEPFSEI-ERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGL 579
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,919,301
Number of Sequences: 37866
Number of extensions: 629375
Number of successful extensions: 2228
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 1072
Number of HSP's gapped (non-prelim): 404
length of query: 350
length of database: 18,247,518
effective HSP length: 103
effective length of query: 247
effective length of database: 14,347,320
effective search space: 3543788040
effective search space used: 3543788040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.