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Search of human proteins with 7549803
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7549803 deiodinase, iodothyronine, type II isoform a [Homo
sapiens]
(273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7549803 deiodinase, iodothyronine, type II isoform a [Homo sa... 544 e-155
gi|7549805 deiodinase, iodothyronine, type II isoform a [Homo sa... 544 e-155
gi|55749998 deiodinase, iodothyronine, type II isoform b [Homo s... 526 e-149
gi|55750011 deiodinase, iodothyronine, type III [Homo sapiens] 152 3e-37
gi|4557522 deiodinase, iodothyronine, type I isoform a [Homo sap... 140 2e-33
gi|47132603 deiodinase, iodothyronine, type I isoform b [Homo sa... 131 7e-31
gi|89357938 deiodinase, iodothyronine, type I isoform d [Homo sa... 72 4e-13
gi|89357935 deiodinase, iodothyronine, type I isoform c [Homo sa... 72 4e-13
gi|169162069 PREDICTED: hypothetical protein [Homo sapiens] 32 0.59
gi|169162780 PREDICTED: hypothetical protein [Homo sapiens] 32 0.59
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 32 0.59
gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 31 1.3
gi|55749600 spire homolog 2 [Homo sapiens] 30 3.0
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 29 3.9
gi|39780588 TSR1, 20S rRNA accumulation [Homo sapiens] 29 3.9
gi|18860918 xylulokinase [Homo sapiens] 28 6.6
gi|62339432 platelet receptor Gi24 [Homo sapiens] 28 8.6
>gi|7549803 deiodinase, iodothyronine, type II isoform a [Homo
sapiens]
Length = 273
Score = 544 bits (1401), Expect = e-155
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL 60
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
Sbjct: 1 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL 60
Query: 61 RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP 120
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
Sbjct: 61 RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP 120
Query: 121 ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF 180
ERPLVVNFGSAT PPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
Sbjct: 121 ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF 180
Query: 181 EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY 240
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
Sbjct: 181 EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY 240
Query: 241 LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG 273
LGGKGPFSYNLQEVRHWLEKNFSKR KKTRLAG
Sbjct: 241 LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG 273
>gi|7549805 deiodinase, iodothyronine, type II isoform a [Homo
sapiens]
Length = 273
Score = 544 bits (1401), Expect = e-155
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL 60
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
Sbjct: 1 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL 60
Query: 61 RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP 120
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
Sbjct: 61 RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP 120
Query: 121 ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF 180
ERPLVVNFGSAT PPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
Sbjct: 121 ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF 180
Query: 181 EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY 240
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
Sbjct: 181 EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY 240
Query: 241 LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG 273
LGGKGPFSYNLQEVRHWLEKNFSKR KKTRLAG
Sbjct: 241 LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG 273
>gi|55749998 deiodinase, iodothyronine, type II isoform b [Homo
sapiens]
Length = 309
Score = 526 bits (1354), Expect = e-149
Identities = 273/309 (88%), Positives = 273/309 (88%), Gaps = 36/309 (11%)
Query: 1 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL 60
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
Sbjct: 1 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL 60
Query: 61 RCVWKSFLLDAYKQ------------------------------------VKLGEDAPNS 84
RCVWKSFLLDAYKQ VKLGEDAPNS
Sbjct: 61 RCVWKSFLLDAYKQLNCPPSGFSKDGHILULVYEAYKSRLLVYSHLDLWMVKLGEDAPNS 120
Query: 85 SVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFR 144
SVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSAT PPFTSQLPAFR
Sbjct: 121 SVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFR 180
Query: 145 KLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSL 204
KLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSL
Sbjct: 181 KLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSL 240
Query: 205 PPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSK 264
PPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSK
Sbjct: 241 PPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSK 300
Query: 265 RUKKTRLAG 273
R KKTRLAG
Sbjct: 301 RUKKTRLAG 309
>gi|55750011 deiodinase, iodothyronine, type III [Homo sapiens]
Length = 278
Score = 152 bits (384), Expect = 3e-37
Identities = 86/208 (41%), Positives = 124/208 (59%), Gaps = 23/208 (11%)
Query: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATC 112
R+ T L+ VW LD +KQ G APNS VV +G Q +
Sbjct: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVV----------LPDGFQSQ------- 123
Query: 113 HLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAI 172
H+LD+A RPLV+NFGS T PPF +++ AF++LV ++ DFL++YI+EAHPSDGW +
Sbjct: 124 HILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182
Query: 173 PGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCI 232
DS + + +H++ EDR +AA+ L + P C +V D M N+++ AYG FER+ +
Sbjct: 183 TTDS--PYIIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237
Query: 233 VQRQKIAYLGGKGPFSYNLQEVRHWLEK 260
+Q I Y GG+GP Y + E+R WLE+
Sbjct: 238 IQSGTIMYQGGRGPDGYQVSELRTWLER 265
>gi|4557522 deiodinase, iodothyronine, type I isoform a [Homo
sapiens]
Length = 249
Score = 140 bits (352), Expect = 2e-33
Identities = 79/185 (42%), Positives = 107/185 (57%), Gaps = 25/185 (13%)
Query: 76 KLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPP 135
+LG APN VV +S G C++ +F RPLV+NFGS T P
Sbjct: 87 ELGGLAPNCPVVRLS------------------GQRCNIWEFMQGNRPLVLNFGSCTUPS 128
Query: 136 FTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAA 195
F + F++L+E+FSS+ADFL++YI+EAH SDGWA + +++ HQN +DR AA
Sbjct: 129 FMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKN----NMDIRNHQNLQDRLQAA 184
Query: 196 QQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVR 255
LL R PQC VV D M N ++ Y ER+ I+Q +I Y G GP++YN +EVR
Sbjct: 185 HLLLAR---SPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVR 241
Query: 256 HWLEK 260
LEK
Sbjct: 242 AVLEK 246
>gi|47132603 deiodinase, iodothyronine, type I isoform b [Homo
sapiens]
Length = 185
Score = 131 bits (329), Expect = 7e-31
Identities = 68/139 (48%), Positives = 91/139 (65%), Gaps = 7/139 (5%)
Query: 122 RPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFE 181
RPLV+NFGS T P F + F++L+E+FSS+ADFL++YI+EAH SDGWA + +
Sbjct: 51 RPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKN----NMD 106
Query: 182 VKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYL 241
++ HQN +DR AA LL R PQC VV D M N ++ Y ER+ I+Q +I Y
Sbjct: 107 IRNHQNLQDRLQAAHLLLAR---SPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYK 163
Query: 242 GGKGPFSYNLQEVRHWLEK 260
G GP++YN +EVR LEK
Sbjct: 164 GKSGPWNYNPEEVRAVLEK 182
>gi|89357938 deiodinase, iodothyronine, type I isoform d [Homo
sapiens]
Length = 161
Score = 72.4 bits (176), Expect = 4e-13
Identities = 39/92 (42%), Positives = 54/92 (58%), Gaps = 18/92 (19%)
Query: 76 KLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPP 135
+LG APN VV +S G C++ +F RPLV+NFGS T P
Sbjct: 87 ELGGLAPNCPVVRLS------------------GQRCNIWEFMQGNRPLVLNFGSCTUPS 128
Query: 136 FTSQLPAFRKLVEEFSSVADFLLVYIDEAHPS 167
F + F++L+E+FSS+ADFL++YI+EAH S
Sbjct: 129 FMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS 160
>gi|89357935 deiodinase, iodothyronine, type I isoform c [Homo
sapiens]
Length = 201
Score = 72.4 bits (176), Expect = 4e-13
Identities = 40/93 (43%), Positives = 53/93 (56%), Gaps = 7/93 (7%)
Query: 168 DGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAF 227
DGWA + +++ HQN +DR AA LL R PQC VV D M N ++ Y
Sbjct: 113 DGWAFKNN----MDIRNHQNLQDRLQAAHLLLAR---SPQCPVVVDTMQNQSSQLYAALP 165
Query: 228 ERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEK 260
ER+ I+Q +I Y G GP++YN +EVR LEK
Sbjct: 166 ERLYIIQEGRILYKGKSGPWNYNPEEVRAVLEK 198
>gi|169162069 PREDICTED: hypothetical protein [Homo sapiens]
Length = 530
Score = 32.0 bits (71), Expect = 0.59
Identities = 22/77 (28%), Positives = 31/77 (40%), Gaps = 11/77 (14%)
Query: 70 DAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFG 129
D + + +D SSV+ + S G +GT+ K SP P+ NF
Sbjct: 151 DQHNPLDFVQDQGRSSVLKLISRRGRSTVNSGTKNKNN-----------SPLAPIFFNFH 199
Query: 130 SATUPPFTSQLPAFRKL 146
S PP TS P R +
Sbjct: 200 SLRNPPITSLAPTTRHI 216
>gi|169162780 PREDICTED: hypothetical protein [Homo sapiens]
Length = 530
Score = 32.0 bits (71), Expect = 0.59
Identities = 22/77 (28%), Positives = 31/77 (40%), Gaps = 11/77 (14%)
Query: 70 DAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFG 129
D + + +D SSV+ + S G +GT+ K SP P+ NF
Sbjct: 151 DQHNPLDFVQDQGRSSVLKLISRRGRSTVNSGTKNKNN-----------SPLAPIFFNFH 199
Query: 130 SATUPPFTSQLPAFRKL 146
S PP TS P R +
Sbjct: 200 SLRNPPITSLAPTTRHI 216
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 32.0 bits (71), Expect = 0.59
Identities = 16/62 (25%), Positives = 32/62 (51%)
Query: 204 LPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFS 263
+P + R V+ R NN N + + + ++ K+ + K S+ + ++H LE+N+S
Sbjct: 2 IPGKYRSVSGRAANNVNCGLHLVIQTSSLPEKNKVEFKLNKDTSSFPGRLLQHDLERNYS 61
Query: 264 KR 265
R
Sbjct: 62 SR 63
>gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo
sapiens]
Length = 1706
Score = 30.8 bits (68), Expect = 1.3
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 65 KSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNG-TQEKIAEGATCHLLDFASPERP 123
+ F+ +A++Q L N S V V+ T G + EK+ + ++ + +P +
Sbjct: 740 QDFIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKS 799
Query: 124 LVVNFGSATUPPFTSQLPAFRKLVEEFS 151
LV + FT LPA R L F+
Sbjct: 800 LVGQVAATVENRFTKTLPAGRTLCGAFT 827
>gi|55749600 spire homolog 2 [Homo sapiens]
Length = 714
Score = 29.6 bits (65), Expect = 3.0
Identities = 22/94 (23%), Positives = 37/94 (39%), Gaps = 3/94 (3%)
Query: 118 ASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSS 177
+ P PL+ N GS+ P S P + L EFS + L + ++E + +
Sbjct: 495 SDPSHPLLSNRGSSGDRPEASMTPDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEME 554
Query: 178 LSFEVKKHQNQEDR---CAAAQQLLERFSLPPQC 208
+ K+ + + C + FS PP C
Sbjct: 555 KFLQNKELFSSLKKGKICCCCRAKFPLFSWPPSC 588
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 29.3 bits (64), Expect = 3.9
Identities = 26/82 (31%), Positives = 39/82 (47%), Gaps = 10/82 (12%)
Query: 174 GDSSLSFEVK-KHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNA---NIAYGVAFE- 228
G S+S EV+ + Q QE+R ++ Q + SLP Q R A + ++ N + G F+
Sbjct: 1193 GRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQS 1252
Query: 229 -----RVCIVQRQKIAYLGGKG 245
R Q + YLGG G
Sbjct: 1253 AKENPRYSSYQGSRNGYLGGHG 1274
>gi|39780588 TSR1, 20S rRNA accumulation [Homo sapiens]
Length = 804
Score = 29.3 bits (64), Expect = 3.9
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Query: 136 FTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLS 179
FTS P +V + + VAD +L +D P +GW GD LS
Sbjct: 135 FTSARPGDLHVVLDMAKVADTILFLLD---PLEGWDSTGDYCLS 175
>gi|18860918 xylulokinase [Homo sapiens]
Length = 536
Score = 28.5 bits (62), Expect = 6.6
Identities = 12/30 (40%), Positives = 19/30 (63%)
Query: 193 AAAQQLLERFSLPPQCRVVADRMDNNANIA 222
A + ++R+ PP C+VVA DN A++A
Sbjct: 257 AISSYYVQRYGFPPGCKVVAFTGDNPASLA 286
>gi|62339432 platelet receptor Gi24 [Homo sapiens]
Length = 311
Score = 28.1 bits (61), Expect = 8.6
Identities = 16/37 (43%), Positives = 25/37 (67%), Gaps = 3/37 (8%)
Query: 74 QVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGA 110
QV+ G+DAP++ VV+ SS++ +S N T +A GA
Sbjct: 167 QVQTGKDAPSNCVVYPSSSQ---DSENITAAALATGA 200
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,207,872
Number of Sequences: 37866
Number of extensions: 437821
Number of successful extensions: 1056
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1036
Number of HSP's gapped (non-prelim): 17
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.