Search of human proteins with 71067341

Search of human proteins with 71067341

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71067341 cerebral cavernous malformation 2 isoform 1 [Homo
sapiens]
         (465 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71067341 cerebral cavernous malformation 2 isoform 1 [Homo sa...   922   0.0  
gi|13899275 cerebral cavernous malformation 2 isoform 2 [Homo sa...   857   0.0  
gi|31542255 hypothetical protein LOC140706 [Homo sapiens]             137   2e-32
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    32   1.6  
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    32   1.6  
gi|4557757 MutL protein homolog 1 [Homo sapiens]                       31   2.1  
gi|12383066 axotrophin [Homo sapiens]                                  30   3.6  
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]    30   4.7  
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    30   4.7  
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    30   4.7  
gi|22095355 basic, immunoglobulin-like variable motif containing...    30   6.1  
gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]        30   6.1  
gi|196115153 CDKN1A interacting zinc finger protein 1 isoform 3 ...    29   7.9  

>gi|71067341 cerebral cavernous malformation 2 isoform 1 [Homo
           sapiens]
          Length = 465

 Score =  922 bits (2382), Expect = 0.0
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTER 60
           MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTER
Sbjct: 1   MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTER 60

Query: 61  RPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAH 120
           RPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAH
Sbjct: 61  RPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAH 120

Query: 121 QLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQ 180
           QLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQ
Sbjct: 121 QLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQ 180

Query: 181 DPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQV 240
           DPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQV
Sbjct: 181 DPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQV 240

Query: 241 VYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGA 300
           VYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGA
Sbjct: 241 VYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGA 300

Query: 301 SPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLR 360
           SPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLR
Sbjct: 301 SPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLR 360

Query: 361 QLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSST 420
           QLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSST
Sbjct: 361 QLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSST 420

Query: 421 TNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA 465
           TNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
Sbjct: 421 TNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA 465


>gi|13899275 cerebral cavernous malformation 2 isoform 2 [Homo
           sapiens]
          Length = 444

 Score =  857 bits (2215), Expect = 0.0
 Identities = 434/435 (99%), Positives = 435/435 (100%)

Query: 31  EPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKY 90
           +PGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKY
Sbjct: 10  KPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKY 69

Query: 91  LGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGED 150
           LGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGED
Sbjct: 70  LGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGED 129

Query: 151 IILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGP 210
           IILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGP
Sbjct: 130 IILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGP 189

Query: 211 VEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSD 270
           VEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSD
Sbjct: 190 VEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSD 249

Query: 271 DSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTK 330
           DSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTK
Sbjct: 250 DSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTK 309

Query: 331 LSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFL 390
           LSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFL
Sbjct: 310 LSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFL 369

Query: 391 ETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDIS 450
           ETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDIS
Sbjct: 370 ETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDIS 429

Query: 451 SDIEALGCSMDQDSA 465
           SDIEALGCSMDQDSA
Sbjct: 430 SDIEALGCSMDQDSA 444


>gi|31542255 hypothetical protein LOC140706 [Homo sapiens]
          Length = 433

 Score =  137 bits (346), Expect = 2e-32
 Identities = 74/159 (46%), Positives = 104/159 (65%), Gaps = 5/159 (3%)

Query: 29  ENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPER-VEPDRLLSDYIEKE 87
           + + G VSP +R+     K+  + A      RRPLH++ L  P+  ++P  LL DY+EKE
Sbjct: 7   KGKKGFVSPIRRLVFP--KAGRRAACRSSVSRRPLHSMPLYPPDYLIDPQILLCDYLEKE 64

Query: 88  VKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRD 147
           VK+LG LT +   LNPSSR E+L  +D A++  +LP   T E D++LSLSA  + L WRD
Sbjct: 65  VKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTAEQDSILSLSARCLLLTWRD 124

Query: 148 GEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISP 186
            E++ILR+P H+IAA SY++DDA HL+VLKT    G+ P
Sbjct: 125 NEELILRIPTHEIAAASYLQDDALHLLVLKTGL--GVDP 161



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 25/52 (48%), Positives = 35/52 (67%)

Query: 210 PVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTP 261
           P   C LVILA  ++ AAEE C L+ QVFQ++Y + +I+ +DRA +   STP
Sbjct: 297 PDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYTSTP 348


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform
           2 [Homo sapiens]
          Length = 8749

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)

Query: 134 LSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPG 183
           L +S  NVKL  +D EDI  RVP+ D  A   +    AHL+  ++ Q+ G
Sbjct: 742 LEVSFMNVKLLIQDLEDIEQRVPVMD--AQYKIITKTAHLITKESPQEEG 789


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform
           1 [Homo sapiens]
          Length = 8797

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)

Query: 134 LSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPG 183
           L +S  NVKL  +D EDI  RVP+ D  A   +    AHL+  ++ Q+ G
Sbjct: 735 LEVSFMNVKLLIQDLEDIEQRVPVMD--AQYKIITKTAHLITKESPQEEG 782


>gi|4557757 MutL protein homolog 1 [Homo sapiens]
          Length = 756

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 17/55 (30%), Positives = 27/55 (49%)

Query: 83  YIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLS 137
           YI +E    GQ + +PG +  S +  + H +  A R+H LP     E   +L L+
Sbjct: 690 YISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLA 744


>gi|12383066 axotrophin [Homo sapiens]
          Length = 704

 Score = 30.4 bits (67), Expect = 3.6
 Identities = 21/67 (31%), Positives = 34/67 (50%), Gaps = 3/67 (4%)

Query: 146 RDGEDIILRVPIHDIAAVSYV-RDDAAHLVVLKTAQDP--GISPSQSLCAESSRGLSAGS 202
           R+G D   R+P  D ++ S++ R ++  +V L+   DP    +      A SS   + GS
Sbjct: 403 REGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGS 462

Query: 203 LSESAVG 209
            S+SA G
Sbjct: 463 TSDSAQG 469


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 6/90 (6%)

Query: 77  DRLLSDYIEKEVKYLGQLTSIPGYLNPSS-RTEILHFIDNAKRAHQLPGHLTQEH---DA 132
           D  + D  +  +KY G++T IP  +  SS + ++ +F  + +      G  + +    D 
Sbjct: 130 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 189

Query: 133 VLSLSAYNVKLAWRDGEDIILRVP--IHDI 160
           VL  S+ N+K  W  GE  I++ P   HDI
Sbjct: 190 VLIGSSMNLKDYWESGEWAIIKAPGYKHDI 219


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 2/42 (4%)

Query: 92   GQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAV 133
            G L+S P  LNP+    +L  +   +   + PGHL  EH A+
Sbjct: 1275 GDLSSAPQELNPAVTAALLQLLSQPEA--EPPGHLPHEHQAL 1314


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 2/42 (4%)

Query: 92   GQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAV 133
            G L+S P  LNP+    +L  +   +   + PGHL  EH A+
Sbjct: 1284 GDLSSAPQELNPAVTAALLQLLSQPEA--EPPGHLPHEHQAL 1323


>gi|22095355 basic, immunoglobulin-like variable motif containing
           isoform a [Homo sapiens]
          Length = 503

 Score = 29.6 bits (65), Expect = 6.1
 Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 12/104 (11%)

Query: 185 SPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTE 244
           +PS+S C   S  LSAG+ S   +G   +   +I   E+ +  E L   LG++       
Sbjct: 87  NPSRSPCLPDSTSLSAGNNSSRYIGIPTSTSEIIYNEENSL--ENLSNSLGKL------- 137

Query: 245 STIDFLDRAIFDGASTPTHHLSLHSDDSSTK---VDIKETYEVE 285
                +D++ FDG +T + H S ++    +K    D K  Y+ E
Sbjct: 138 PLAWEIDKSEFDGVTTNSKHKSGNAKKQVSKRKTSDKKGRYQKE 181


>gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]
          Length = 4857

 Score = 29.6 bits (65), Expect = 6.1
 Identities = 14/47 (29%), Positives = 25/47 (53%)

Query: 297  VGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALL 343
            + G SPH       ++  +AT+ +Q+++  L+  LSS   Q F+  L
Sbjct: 2766 LSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFL 2812


>gi|196115153 CDKN1A interacting zinc finger protein 1 isoform 3
           [Homo sapiens]
          Length = 837

 Score = 29.3 bits (64), Expect = 7.9
 Identities = 17/35 (48%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 407 GRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE 441
           GR+ +  + TSSSTT  NR T   +D+S P EG E
Sbjct: 178 GRNPQKQARTSSSTTP-NRKTMPVEDKSDPPEGSE 211


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,143,861
Number of Sequences: 37866
Number of extensions: 731268
Number of successful extensions: 2440
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2427
Number of HSP's gapped (non-prelim): 17
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.