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Search of human proteins with 67763816
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A
[Homo sapiens]
(690 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 1388 0.0
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 1388 0.0
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 1388 0.0
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 1388 0.0
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 1248 0.0
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 927 0.0
gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Ho... 729 0.0
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 620 e-177
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 294 2e-79
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 178 2e-44
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 176 6e-44
gi|134152694 guanylate cyclase 2F [Homo sapiens] 171 2e-42
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 166 5e-41
gi|222080083 guanylate cyclase 2C [Homo sapiens] 158 2e-38
gi|24497587 adenylate cyclase 4 [Homo sapiens] 122 8e-28
gi|115387102 adenylate cyclase 2 [Homo sapiens] 122 1e-27
gi|4557255 adenylate cyclase 7 [Homo sapiens] 118 2e-26
gi|31083193 adenylate cyclase 1 [Homo sapiens] 117 3e-26
gi|148536830 adenylate cyclase 3 [Homo sapiens] 117 5e-26
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 109 1e-23
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 109 1e-23
gi|34486092 adenylate cyclase 5 [Homo sapiens] 106 6e-23
gi|4557257 adenylate cyclase 8 [Homo sapiens] 101 2e-21
gi|50959205 adenylate cyclase 9 [Homo sapiens] 101 3e-21
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 31 3.4
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 30 5.7
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 30 5.7
gi|33188445 microfilament and actin filament cross-linker protei... 30 7.5
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 30 7.5
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 30 7.5
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 1388 bits (3593), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
Sbjct: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
Query: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
Sbjct: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
Query: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
Sbjct: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
Query: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
Sbjct: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
Query: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
Sbjct: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
Query: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
Sbjct: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
Query: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
Sbjct: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
Query: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
Sbjct: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
Query: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
Sbjct: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
Query: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
Sbjct: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
Query: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
Sbjct: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
Query: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
QQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 1388 bits (3593), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
Sbjct: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
Query: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
Sbjct: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
Query: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
Sbjct: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
Query: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
Sbjct: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
Query: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
Sbjct: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
Query: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
Sbjct: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
Query: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
Sbjct: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
Query: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
Sbjct: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
Query: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
Sbjct: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
Query: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
Sbjct: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
Query: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
Sbjct: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
Query: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
QQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 1388 bits (3593), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
Sbjct: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
Query: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
Sbjct: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
Query: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
Sbjct: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
Query: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
Sbjct: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
Query: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
Sbjct: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
Query: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
Sbjct: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
Query: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
Sbjct: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
Query: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
Sbjct: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
Query: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
Sbjct: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
Query: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
Sbjct: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
Query: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
Sbjct: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
Query: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
QQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 1388 bits (3593), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
Sbjct: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
Query: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
Sbjct: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
Query: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
Sbjct: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
Query: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
Sbjct: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
Query: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
Sbjct: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
Query: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
Sbjct: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
Query: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
Sbjct: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
Query: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
Sbjct: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
Query: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
Sbjct: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
Query: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
Sbjct: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
Query: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
Sbjct: 601 VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY 660
Query: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
QQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 661 QQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 1248 bits (3228), Expect = 0.0
Identities = 624/624 (100%), Positives = 624/624 (100%)
Query: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
Sbjct: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
Query: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
Sbjct: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
Query: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
Sbjct: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
Query: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
Sbjct: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
Query: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
Sbjct: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
Query: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
Sbjct: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
Query: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
Sbjct: 361 SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR 420
Query: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
Sbjct: 421 AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV 480
Query: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
Sbjct: 481 TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK 540
Query: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
Sbjct: 541 ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN 600
Query: 601 VTLANKFESCSVPRKINVSPTTYR 624
VTLANKFESCSVPRKINVSPTTYR
Sbjct: 601 VTLANKFESCSVPRKINVSPTTYR 624
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 927 bits (2397), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
Query: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
Query: 356 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
Query: 416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 475
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
Query: 476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 535
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
Query: 536 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 595
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
Query: 596 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 655
LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH
Sbjct: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
Query: 656 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 690
FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
>gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Homo
sapiens]
Length = 366
Score = 729 bits (1883), Expect = 0.0
Identities = 363/363 (100%), Positives = 363/363 (100%)
Query: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
Sbjct: 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP 60
Query: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
Sbjct: 61 QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE 120
Query: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
Sbjct: 121 QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG 180
Query: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
Sbjct: 181 KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF 240
Query: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
Sbjct: 241 HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ 300
Query: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
Sbjct: 301 FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS 360
Query: 361 SRV 363
SRV
Sbjct: 361 SRV 363
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 620 bits (1598), Expect = e-177
Identities = 345/700 (49%), Positives = 452/700 (64%), Gaps = 36/700 (5%)
Query: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
Query: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
Query: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
Query: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
Query: 229 TEVEVSLMP-PCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLIK-ECENTNIMKNLPQGTSQVPADLRISINT 322
Query: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
Query: 342 LNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401
L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD+L++ GRGL+LS
Sbjct: 382 LSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLS 441
Query: 402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
DIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKKKTVDLL SIFP +
Sbjct: 442 DIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGD 501
Query: 462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN LYTRFD QCG LD
Sbjct: 502 VAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLD 561
Query: 522 VYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G PI+MRIG+HSGS
Sbjct: 562 IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
Query: 582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE 641
V AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+LLK F F PRSREE
Sbjct: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
Query: 642 LPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
LP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 682 LPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 294 bits (752), Expect = 2e-79
Identities = 192/515 (37%), Positives = 281/515 (54%), Gaps = 28/515 (5%)
Query: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
Query: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
Query: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
Query: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSS------- 361
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG 298
Query: 362 ---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ 418
+ LKGQMIY+ E+ +ILFL SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ
Sbjct: 299 TEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ 358
Query: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFS 478
R + L + L L L+ +ALE+EKKKT LL S+ P VA +L + V AK++
Sbjct: 359 FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYD 418
Query: 479 NVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVETIGDA 531
NVT+LFS IVGF A CS+ + ++++ +LN LYTRFD VYKVET+GD
Sbjct: 419 NVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDK 478
Query: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Y GL + HA I +AL MME++ +V GE +++ IG+H+G V GV+G +M
Sbjct: 479 YMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRM 537
Query: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
PRYCLFGN V L ++ E+ KINVS TYR L
Sbjct: 538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 178 bits (451), Expect = 2e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
Query: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
Query: 544 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
Query: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
A++ ES KI++S T +L++ GF R E+
Sbjct: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 176 bits (446), Expect = 6e-44
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
Query: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 543
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
Query: 544 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
Query: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
A++ ES KI+VS TT L + F R E+
Sbjct: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 171 bits (434), Expect = 2e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
Query: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
Query: 532 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Query: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 642
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 166 bits (421), Expect = 5e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
Query: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
Query: 532 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Query: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 647
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
Query: 648 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
+ F ++G N KP + D++ G++N
Sbjct: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 158 bits (399), Expect = 2e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 432 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 491
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
Query: 492 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 550
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
Query: 551 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
Query: 609 SCSVPRKINVSPTTYRLLK 627
S +P +I+VS +T +LK
Sbjct: 955 STGLPLRIHVSGSTIAILK 973
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 122 bits (307), Expect = 8e-28
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)
Query: 432 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 470
L+AT +A + L+ EKK LL SI P E+ +L GQ
Sbjct: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
Query: 471 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526
+ K+ V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ E + +++
Sbjct: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
Query: 527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 586
+GD Y GL HA+ M L M ++ + G I MR+G+HSGSV GV
Sbjct: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
Query: 587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
+G++ +Y ++ ++VTLAN E+ VP +++++ T LL
Sbjct: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
Score = 72.8 bits (177), Expect = 1e-12
Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)
Query: 433 KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 488
K L Q + E + T LL ++ P VA Q + + + + + V +LF+ +
Sbjct: 821 KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
Query: 489 GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 541
F S+ + L+ + +LN + FD+ + V K++TIG Y A GL+
Sbjct: 881 DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
Query: 542 SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 590
S A Q A + M+E + +V++ H ++R+GL+ G V AGV+G +
Sbjct: 941 SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
Query: 591 MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622
P+Y ++GN V +A++ ES V KI V+ T
Sbjct: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 122 bits (306), Expect = 1e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 482
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
Query: 483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 542
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
Query: 543 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
Query: 603 LANKFESCSVPRKINVSPTT 622
LAN E+ VP ++++S T
Sbjct: 412 LANHMEAGGVPGRVHISSVT 431
Score = 65.5 bits (158), Expect = 2e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 444 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 494
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
Query: 495 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 539
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
Query: 540 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 596
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
Query: 597 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 627
+GN V +A++ +S V KI V+ T +L+
Sbjct: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 118 bits (295), Expect = 2e-26
Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)
Query: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 478
Q + L EK++ +LL S+ P ++ + + + K+
Sbjct: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
Query: 479 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 538
NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ + +++ +GD Y GL
Sbjct: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
Query: 539 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 598
THA M L M + +V G I MR+G+HSG+V GV+G++ +Y ++
Sbjct: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
Query: 599 NNVTLANKFESCSVPRKINVSPTTYRLL 626
++V+LAN+ E+ VP +++++ T + L
Sbjct: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)
Query: 433 KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 489
K ++ H+ E + LL ++ P VA ++ + + + V ++F+ +
Sbjct: 828 KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
Query: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 538
F ++C L+ + +LN + FD+ + V K++TIG Y A GL
Sbjct: 888 FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
Query: 539 ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
++E + I +M ++ +M D + ++R+G++ G V AGV+G + P
Sbjct: 948 GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
Query: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 633
+Y ++GN V +A++ ES KI V+ T +L+ +C G +
Sbjct: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 117 bits (294), Expect = 3e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 493
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
Query: 494 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 553
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
Query: 554 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 613
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
Query: 614 RKINVSPTTYRLL 626
K++++ TT L
Sbjct: 436 GKVHITKTTLACL 448
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 434 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 489
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
Query: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 542
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
Query: 543 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 594
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
Query: 595 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 630
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 117 bits (292), Expect = 5e-26
Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)
Query: 443 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 489
LEE+ ++ +L+ SI P VA ++ Q + + NV++LF+DIVG
Sbjct: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
Query: 490 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 549
FT + S CS +++ +LN L+ RFD+ + +++ +GD Y GL + HAV
Sbjct: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
Query: 550 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 609
LM L M+E V + MR+G+H+G+V GV+G K +Y ++ +VT+ANK E+
Sbjct: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
Query: 610 CSVPRKINVSPTTYRLLK 627
+P ++++S +T LK
Sbjct: 448 GGIPGRVHISQSTMDCLK 465
Score = 65.9 bits (159), Expect = 1e-10
Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)
Query: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 474
+R + L + L K + + + E ++ L+ ++ P VA+ + + + +
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 475 KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 527
+ + + ++F+ + F ++ S ++ + LN + + FD + K++T
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 528 IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 569
IG Y A G+ + +T H +A AL M + + +
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 570 PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 629
+RIG++ G V AGV+G + P Y ++GN V +A++ ES V I V T +L++
Sbjct: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
Query: 630 PGFVFTPR 637
GF F R
Sbjct: 1097 -GFRFVRR 1103
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 109 bits (272), Expect = 1e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
Query: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
Query: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
Query: 608 ESCSVPRKINVSPTTYRLL 626
E+ +I+++ T + L
Sbjct: 506 EAGGRAGRIHITRATLQYL 524
Score = 80.5 bits (197), Expect = 5e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
Query: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
Query: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
Query: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 109 bits (272), Expect = 1e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
Query: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
Query: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
Query: 608 ESCSVPRKINVSPTTYRLL 626
E+ +I+++ T + L
Sbjct: 506 EAGGRAGRIHITRATLQYL 524
Score = 80.5 bits (197), Expect = 5e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 872 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
Query: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 930 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
Query: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 990 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
Query: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 106 bits (265), Expect = 6e-23
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 487
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
Query: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
Query: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
Query: 608 ESCSVPRKINVSPTTYRLL 626
E+ +I+++ T L
Sbjct: 596 EAGGKAGRIHITKATLNYL 614
Score = 83.6 bits (205), Expect = 6e-16
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
Query: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
Query: 538 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
Query: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 101 bits (252), Expect = 2e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 484
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
Query: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
Query: 545 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
Query: 605 NKFESCSVPRKINVSPTT 622
NK ES +P +I++S T
Sbjct: 538 NKLESGGIPGRIHISKAT 555
Score = 94.0 bits (232), Expect = 4e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 498
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
Query: 499 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 545
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
Query: 546 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 605
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
Query: 606 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
+ +S V +I V TY +LKD GF F R
Sbjct: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 101 bits (251), Expect = 3e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 475 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 533
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
Query: 534 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 593
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
Query: 594 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
Score = 63.5 bits (153), Expect = 6e-10
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 453 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 510
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
Query: 511 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 560
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
Query: 561 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
Query: 620 PTTYRLL 626
+YR+L
Sbjct: 1210 EESYRVL 1216
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 31.2 bits (69), Expect = 3.4
Identities = 41/181 (22%), Positives = 68/181 (37%), Gaps = 19/181 (10%)
Query: 23 GQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLI 82
GQ P +E A + P +D E+ +E + + R L A++ +
Sbjct: 276 GQEPPLEAERAPREEQQRSLEAPGWEDA-ERREREERERLEAEEERRRLQAQAQAEERRR 334
Query: 83 FPEFERLNVALQRTLAKHKIKESRKSLEREDFE--KTIAEQAVAAGVPVEVIKES----- 135
E RL ++ + + E K E E+ E + + +Q P E ++E+
Sbjct: 335 LEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRR 394
Query: 136 ------LGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDAS 189
LGEE EE + L G L + LN F L+ + G+R E+
Sbjct: 395 GAEEEDLGEEE-----EEGQAHLEDWRGQLSELLNDFEERLEDQERLKPEGQREHSEEPG 449
Query: 190 I 190
I
Sbjct: 450 I 450
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 30.4 bits (67), Expect = 5.7
Identities = 27/107 (25%), Positives = 45/107 (42%), Gaps = 20/107 (18%)
Query: 53 KNIQESLPQRKTSRSRVYL-------------------HTLAESICK-LIFPEFERLNVA 92
KN + + P++KT+ SR+ + HT ESI + L+ R+N
Sbjct: 282 KNSKHNTPRKKTNPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNRE 341
Query: 93 LQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEE 139
+ + H K S +L R +EK + A+ A ++ SL E
Sbjct: 342 EKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENASILTSSLTAE 388
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 30.4 bits (67), Expect = 5.7
Identities = 27/107 (25%), Positives = 45/107 (42%), Gaps = 20/107 (18%)
Query: 53 KNIQESLPQRKTSRSRVYL-------------------HTLAESICK-LIFPEFERLNVA 92
KN + + P++KT+ SR+ + HT ESI + L+ R+N
Sbjct: 282 KNSKHNTPRKKTNPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNRE 341
Query: 93 LQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEE 139
+ + H K S +L R +EK + A+ A ++ SL E
Sbjct: 342 EKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENASILTSSLTAE 388
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 30.0 bits (66), Expect = 7.5
Identities = 32/135 (23%), Positives = 56/135 (41%), Gaps = 14/135 (10%)
Query: 70 YLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPV 129
Y L +S ++F +RL + + K + + KS+E ED E+T+A+ ++ +
Sbjct: 997 YEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNI 1056
Query: 130 EVIKESLGEEVFKICYEEDENILGVVGG-TLKDFLNSFSTLLKQSSHCQE--AGKRGRLE 186
+ E + V K I + T +D + + + H QE R L+
Sbjct: 1057 RLRLEEYEQRVVK-------RIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLD 1109
Query: 187 DASILCLDKEDDFLH 201
S+ C D FLH
Sbjct: 1110 AVSMKC----DSFLH 1120
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 30.0 bits (66), Expect = 7.5
Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 3/90 (3%)
Query: 53 KNIQESLPQRKTS--RSRVYLHTLAESICK-LIFPEFERLNVALQRTLAKHKIKESRKSL 109
KN + + P++K + R HT ESI + L+ R+N + + H K S +L
Sbjct: 282 KNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNL 341
Query: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEE 139
R +EK + A+ A ++ SL E
Sbjct: 342 HRRQWEKNVPNTALTALENASILTSSLTAE 371
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 30.0 bits (66), Expect = 7.5
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Query: 7 KDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATV-PICQDIP 51
K+L +T P L G +PN +EA S+E TV P +++P
Sbjct: 2598 KNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELP 2643
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,053,219
Number of Sequences: 37866
Number of extensions: 1184655
Number of successful extensions: 3140
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3074
Number of HSP's gapped (non-prelim): 49
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.