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Search of human proteins with 67551261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
(484 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 1021 0.0
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 1021 0.0
gi|10190706 CDC-like kinase 4 [Homo sapiens] 791 0.0
gi|47717134 CDC-like kinase 2 [Homo sapiens] 550 e-157
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 483 e-136
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 483 e-136
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 213 4e-55
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 213 4e-55
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 207 2e-53
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 207 2e-53
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 203 2e-52
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 184 1e-46
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 184 2e-46
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 178 1e-44
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 171 1e-42
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 171 1e-42
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 166 6e-41
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 166 6e-41
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 162 5e-40
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 162 5e-40
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 159 5e-39
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 145 1e-34
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 136 4e-32
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 136 4e-32
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 126 5e-29
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 1021 bits (2641), Expect = 0.0
Identities = 484/484 (100%), Positives = 484/484 (100%)
Query: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
Sbjct: 43 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 102
Query: 61 SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 120
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
Sbjct: 103 SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 162
Query: 121 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 180
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
Sbjct: 163 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 222
Query: 181 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 240
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
Sbjct: 223 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 282
Query: 241 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 300
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
Sbjct: 283 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 342
Query: 301 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 360
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
Sbjct: 343 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 402
Query: 361 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 420
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
Sbjct: 403 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 462
Query: 421 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 480
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
Sbjct: 463 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 522
Query: 481 KKSI 484
KKSI
Sbjct: 523 KKSI 526
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 1021 bits (2641), Expect = 0.0
Identities = 484/484 (100%), Positives = 484/484 (100%)
Query: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
Sbjct: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
Query: 61 SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 120
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
Sbjct: 61 SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 120
Query: 121 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 180
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
Sbjct: 121 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 180
Query: 181 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 240
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
Sbjct: 181 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 240
Query: 241 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 300
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
Sbjct: 241 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 300
Query: 301 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 360
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
Sbjct: 301 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 360
Query: 361 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 420
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
Sbjct: 361 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 420
Query: 421 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 480
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
Sbjct: 421 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 480
Query: 481 KKSI 484
KKSI
Sbjct: 481 KKSI 484
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 791 bits (2044), Expect = 0.0
Identities = 383/484 (79%), Positives = 422/484 (87%), Gaps = 6/484 (1%)
Query: 1 MRHSKRTYCPDWDDKD-WDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHS-KMCDSHYLE 58
MRHSKRT+CPDWD ++ W + +R S HKR++RSHSS QEN+ CK +H K D HYLE
Sbjct: 1 MRHSKRTHCPDWDSRESWGHESYRGS--HKRKRRSHSSTQENRHCKPHHQFKESDCHYLE 58
Query: 59 SRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHR 118
+RS+NE+DY RRY+DEYRNDY +G P H RD ES Y+ H SKSS RS RSS K K R
Sbjct: 59 ARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRK-R 117
Query: 119 IHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVEC 178
H +SH+ S KSHRRKR+RS+EDDEEGHLICQSGDVL ARYEIVDTLGEGAFGKVVEC
Sbjct: 118 NRHCSSHQ-SRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVEC 176
Query: 179 IDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHIC 238
IDH G HVAVKIVKNV RY EAARSEIQVLEHLN+TDPNS FRCVQMLEWF+HHGH+C
Sbjct: 177 IDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVC 236
Query: 239 IVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQ 298
IVFELLGLSTYDFIKEN FLPF++DHIR+MAYQIC+S+NFLH NKLTHTDLKPENILFV+
Sbjct: 237 IVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVK 296
Query: 299 SDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 358
SDY YN K+KRDERTL N DIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
Sbjct: 297 SDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 356
Query: 359 PCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLD 418
PCDVWSIGCILIEYYLGFTVF THDSKEHLAMMERILGP+P+HMIQKTRKRKYFHH++LD
Sbjct: 357 PCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLD 416
Query: 419 WDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 478
WDEHSSAGRYV RRCKPLKEFML D EHE+LFDL+++MLEYDP +RITL EAL+HPFFD
Sbjct: 417 WDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476
Query: 479 LLKK 482
LLKK
Sbjct: 477 LLKK 480
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 550 bits (1418), Expect = e-157
Identities = 270/487 (55%), Positives = 349/487 (71%), Gaps = 11/487 (2%)
Query: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
M H +R + + + +RS +RR RS SS+ + R + DS+++ SR
Sbjct: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRRE----DSYHVRSR 56
Query: 61 SI-----NEKDYHSRRYIDEYR-NDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYK 114
S +++ + RRY YR NDY++ + D+ Y+ SS RS RSS +
Sbjct: 57 SSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSS-R 115
Query: 115 SKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGK 174
KHR S S SH +R +SVEDD EGHLI GD L RYEIV TLGEG FG+
Sbjct: 116 RKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
Query: 175 VVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHH 234
VV+C+DH+ GG VA+KI+KNV++Y EAAR EI VLE +N DP++ CVQM +WF++H
Sbjct: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
Query: 235 GHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENI 294
GH+CI FELLGLST+DF+K+N +LP+ + +R MA+Q+C++V FLH NKLTHTDLKPENI
Sbjct: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENI 295
Query: 295 LFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILAL 354
LFV SDY YN + KRDER++ + ++VVDFGSAT+D EHHST+VSTRHYRAPEVIL L
Sbjct: 296 LFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILEL 355
Query: 355 GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHH 414
GWSQPCDVWSIGCI+ EYY+GFT+F THD++EHLAMMERILGP+P MI+KTRK+KYF+
Sbjct: 356 GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYR 415
Query: 415 DRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 474
RLDWDE++SAGRYV CKPL+ ++ S+ EH +LFDLI+ MLEY+PAKR+TL EAL+H
Sbjct: 416 GRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQH 475
Query: 475 PFFDLLK 481
PFF L+
Sbjct: 476 PFFARLR 482
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 483 bits (1244), Expect = e-136
Identities = 248/484 (51%), Positives = 318/484 (65%), Gaps = 19/484 (3%)
Query: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
M H KR P+ D Y +R +R+RS+S E R +Y + SR
Sbjct: 149 MHHCKRYRSPEPDP----YLSYRW-----KRRRSYSREHEG-RLRYPSRREPPPRRSRSR 198
Query: 61 SINEKDYHSRRYIDEYRNDYTQGCE---PGHRQRDHESRYQNHSSKSSGRSGRSSYKSKH 117
S + Y RRY E R+ T CE P + + H +S R + K H
Sbjct: 199 SHDRLPYQ-RRY-RERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAH 256
Query: 118 RIH----HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFG 173
H S S S + ++ +RSVEDD+EGHL+C+ GD L RYEIV LGEG FG
Sbjct: 257 HCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFG 316
Query: 174 KVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEH 233
KVVEC+DH G VA+KI++NV +Y EAAR EI VL+ + D + F CV M +WF
Sbjct: 317 KVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF 376
Query: 234 HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPEN 293
HGH+CI FELLG +T++F+KEN F P+ L H+R MAYQ+C ++ FLH N+LTHTDLKPEN
Sbjct: 377 HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 436
Query: 294 ILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 353
ILFV S++ YN +E+++ N I+V DFGSAT+D EHH+T+V+TRHYR PEVIL
Sbjct: 437 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 496
Query: 354 LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFH 413
LGW+QPCDVWSIGCIL EYY GFT+F TH+++EHL MME+ILGP+P HMI +TRK+KYF+
Sbjct: 497 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY 556
Query: 414 HDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALK 473
L WDE+SS GRYV CKPLK +ML +EH +LFDL+++MLE+DPA+RITL EAL
Sbjct: 557 KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALL 616
Query: 474 HPFF 477
HPFF
Sbjct: 617 HPFF 620
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 483 bits (1244), Expect = e-136
Identities = 248/484 (51%), Positives = 318/484 (65%), Gaps = 19/484 (3%)
Query: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
M H KR P+ D Y +R +R+RS+S E R +Y + SR
Sbjct: 1 MHHCKRYRSPEPDP----YLSYRW-----KRRRSYSREHEG-RLRYPSRREPPPRRSRSR 50
Query: 61 SINEKDYHSRRYIDEYRNDYTQGCE---PGHRQRDHESRYQNHSSKSSGRSGRSSYKSKH 117
S + Y RRY E R+ T CE P + + H +S R + K H
Sbjct: 51 SHDRLPYQ-RRY-RERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAH 108
Query: 118 RIH----HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFG 173
H S S S + ++ +RSVEDD+EGHL+C+ GD L RYEIV LGEG FG
Sbjct: 109 HCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFG 168
Query: 174 KVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEH 233
KVVEC+DH G VA+KI++NV +Y EAAR EI VL+ + D + F CV M +WF
Sbjct: 169 KVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF 228
Query: 234 HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPEN 293
HGH+CI FELLG +T++F+KEN F P+ L H+R MAYQ+C ++ FLH N+LTHTDLKPEN
Sbjct: 229 HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 288
Query: 294 ILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 353
ILFV S++ YN +E+++ N I+V DFGSAT+D EHH+T+V+TRHYR PEVIL
Sbjct: 289 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 348
Query: 354 LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFH 413
LGW+QPCDVWSIGCIL EYY GFT+F TH+++EHL MME+ILGP+P HMI +TRK+KYF+
Sbjct: 349 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY 408
Query: 414 HDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALK 473
L WDE+SS GRYV CKPLK +ML +EH +LFDL+++MLE+DPA+RITL EAL
Sbjct: 409 KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALL 468
Query: 474 HPFF 477
HPFF
Sbjct: 469 HPFF 472
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 213 bits (541), Expect = 4e-55
Identities = 126/351 (35%), Positives = 193/351 (54%), Gaps = 37/351 (10%)
Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
DD++G + D ++ RYE++ +G+G+FG+VV+ DHK +HVA+K+V+N R+
Sbjct: 204 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 262
Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
A EI++LEHL D ++T + MLE F HIC+ FELL ++ Y+ IK+N F F L
Sbjct: 263 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 322
Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
+RK A+ I + ++ LH N++ H DLKPENIL Q IK
Sbjct: 323 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-----------------RSGIK 365
Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ + P
Sbjct: 366 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 425
Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDR-----------LDWDEHSSAGRYVSR 431
D + LA M +LG + ++ +++ K F + D + GR SR
Sbjct: 426 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR--SR 483
Query: 432 RCK-----PLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
R K +E+ + + LF D +++ LE+DPA R+T +AL+HP+
Sbjct: 484 RGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 534
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 213 bits (541), Expect = 4e-55
Identities = 126/351 (35%), Positives = 193/351 (54%), Gaps = 37/351 (10%)
Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
DD++G + D ++ RYE++ +G+G+FG+VV+ DHK +HVA+K+V+N R+
Sbjct: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
A EI++LEHL D ++T + MLE F HIC+ FELL ++ Y+ IK+N F F L
Sbjct: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
+RK A+ I + ++ LH N++ H DLKPENIL Q IK
Sbjct: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-----------------RSGIK 292
Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ + P
Sbjct: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDR-----------LDWDEHSSAGRYVSR 431
D + LA M +LG + ++ +++ K F + D + GR SR
Sbjct: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR--SR 410
Query: 432 RCK-----PLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
R K +E+ + + LF D +++ LE+DPA R+T +AL+HP+
Sbjct: 411 RGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 461
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 207 bits (527), Expect = 2e-53
Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)
Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
DD +G I D L+ RYE++ +G+G+FG+V DHK ++VA+K+V+N R+
Sbjct: 171 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 229
Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
A EI++LEHL D + + MLE F H+C+ FELL + Y+ IK+N F F +
Sbjct: 230 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 289
Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
+RK A I +S++ LH NK+ H DLKPENIL +K R+ K
Sbjct: 290 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 332
Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +FP
Sbjct: 333 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 392
Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 433
D + LA M +LG P +++++++ KYF + R + GR V SRR
Sbjct: 393 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 452
Query: 434 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
K K++ + + LF + +++ L +DP+ R+T +AL+HP+
Sbjct: 453 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 501
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 207 bits (527), Expect = 2e-53
Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)
Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
DD +G I D L+ RYE++ +G+G+FG+V DHK ++VA+K+V+N R+
Sbjct: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
A EI++LEHL D + + MLE F H+C+ FELL + Y+ IK+N F F +
Sbjct: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
+RK A I +S++ LH NK+ H DLKPENIL +K R+ K
Sbjct: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 352
Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +FP
Sbjct: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 433
D + LA M +LG P +++++++ KYF + R + GR V SRR
Sbjct: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
Query: 434 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
K K++ + + LF + +++ L +DP+ R+T +AL+HP+
Sbjct: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 203 bits (517), Expect = 2e-52
Identities = 112/339 (33%), Positives = 183/339 (53%), Gaps = 20/339 (5%)
Query: 136 KRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN 195
K +++ DDE G + D ++ RYE+++T+G+G+FG+V +C+DHK VA+KI++N
Sbjct: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHK-NNELVALKIIRN 137
Query: 196 VDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKEN 255
R+ + A E+++LE L D ++T+ V M ++F H CI FELLG++ Y+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
Query: 256 GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERT 315
F F L +R+ + K + L K+ H DLKPENI+ Q
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG--------------- 242
Query: 316 LINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG 375
+KV+DFGS+ Y+ + T + +R YR+PEVIL + D+WS+GCI E Y G
Sbjct: 243 --QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
Query: 376 FTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKP 435
+ +FP + E LA + +LG P IQ +R+ F D + ++ + R +R
Sbjct: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTF-FDSKGFPKNITNNR-GKKRYPD 358
Query: 436 LKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 474
K+ + D +++ L ++P+ R+T +ALKH
Sbjct: 359 SKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKH 397
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 184 bits (468), Expect = 1e-46
Identities = 121/377 (32%), Positives = 192/377 (50%), Gaps = 51/377 (13%)
Query: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
+YK + ++++ RR S K ++ +DD +++ +SG+ RYEI
Sbjct: 55 TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
Query: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
+G+G+FG+VV+ DH+ VA+KI+KN + A+ E+++LE +N D +
Sbjct: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
Query: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
V + F H+C+VFELL + YD ++ F L+ RK+A Q+C ++ FL + +
Sbjct: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
Query: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
L+ H DLKPENIL NPK IK+VDFGS+ + +
Sbjct: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
Query: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
+R YR+PEV+L + D+WS+GCIL+E + G +F + + + + +LG P
Sbjct: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
Query: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEY 460
M+ Q + RKYF E G + RR K L++ DL+ +MLEY
Sbjct: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRK-------------DLVLRMLEY 374
Query: 461 DPAKRITLREALKHPFF 477
+PA RI+ AL+H FF
Sbjct: 375 EPAARISPLGALQHGFF 391
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 184 bits (467), Expect = 2e-46
Identities = 121/377 (32%), Positives = 193/377 (51%), Gaps = 39/377 (10%)
Query: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
+YK + ++++ RR S K ++ +DD +++ +SG+ RYEI
Sbjct: 55 TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
Query: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
+G+G+FG+VV+ DH+ VA+KI+KN + A+ E+++LE +N D +
Sbjct: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
Query: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
V + F H+C+VFELL + YD ++ F L+ RK+A Q+C ++ FL + +
Sbjct: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
Query: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
L+ H DLKPENIL NPK IK+VDFGS+ + +
Sbjct: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
Query: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
+R YR+PEV+L + D+WS+GCIL+E + G +F + + + + +LG P
Sbjct: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
Query: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEY 460
M+ Q + RKYF E G + RR K L++ + DL+ +MLEY
Sbjct: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLEY 386
Query: 461 DPAKRITLREALKHPFF 477
+PA RI+ AL+H FF
Sbjct: 387 EPAARISPLGALQHGFF 403
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 178 bits (451), Expect = 1e-44
Identities = 124/404 (30%), Positives = 198/404 (49%), Gaps = 65/404 (16%)
Query: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
+YK + ++++ RR S K ++ +DD +++ +SG+ RYEI
Sbjct: 55 TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
Query: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
+G+G+FG+VV+ DH+ VA+KI+KN + A+ E+++LE +N D +
Sbjct: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
Query: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
V + F H+C+VFELL + YD ++ F L+ RK+A Q+C ++ FL + +
Sbjct: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
Query: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
L+ H DLKPENIL NPK IK+VDFGS+ + +
Sbjct: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
Query: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
+R YR+PEV+L + D+WS+GCIL+E + G +F + + + + +LG P
Sbjct: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
Query: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLS------QDV--------- 445
M+ Q + RKYF E G + RR K L++ Q+V
Sbjct: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPG 387
Query: 446 ------------EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
++ R DL+ +MLEY+PA RI+ AL+H FF
Sbjct: 388 GRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 172 bits (435), Expect = 8e-43
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162
Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221
Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281
Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324
Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384
Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
+ + K + F D + + R KP L +
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444
Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 172 bits (435), Expect = 8e-43
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162
Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221
Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281
Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324
Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384
Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
+ + K + F D + + R KP L +
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444
Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 172 bits (435), Expect = 8e-43
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162
Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221
Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281
Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324
Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384
Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
+ + K + F D + + R KP L +
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444
Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 172 bits (435), Expect = 8e-43
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 94 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 153
Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 154 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 212
Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 213 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 272
Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 273 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 315
Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 316 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 375
Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
+ + K + F D + + R KP L +
Sbjct: 376 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 435
Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 436 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 172 bits (435), Expect = 8e-43
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162
Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221
Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281
Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324
Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384
Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
+ + K + F D + + R KP L +
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444
Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 171 bits (434), Expect = 1e-42
Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)
Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
YE+++ LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
+ V+ E F+H H C+VFE+L + YDF+K+N F P L +IR + Q+ ++ L
Sbjct: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
S L H DLKPENI+ V + Y +KV+DFGSA++ + ST
Sbjct: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
Query: 400 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 441
++++ T+ ++F+ D W D+H + A +Y+ + + +
Sbjct: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
Query: 442 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 476
+ D+E DL++KML D KRIT E L HPF
Sbjct: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 171 bits (434), Expect = 1e-42
Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)
Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
YE+++ LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257
Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
+ V+ E F+H H C+VFE+L + YDF+K+N F P L +IR + Q+ ++ L
Sbjct: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
S L H DLKPENI+ V + Y +KV+DFGSA++ + ST
Sbjct: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361
Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
Query: 400 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 441
++++ T+ ++F+ D W D+H + A +Y+ + + +
Sbjct: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
Query: 442 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 476
+ D+E DL++KML D KRIT E L HPF
Sbjct: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 166 bits (419), Expect = 6e-41
Identities = 110/371 (29%), Positives = 187/371 (50%), Gaps = 49/371 (13%)
Query: 138 TRSVEDDEEGHLICQSGDVLSAR---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK 194
T+S EG ++L + YE+++ LG G FG+V +C ++ VA+KI+K
Sbjct: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILK 222
Query: 195 NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE 254
N Y + E+ +L L++ + + + V+ E F+H H C+VFE+L + YDF+K+
Sbjct: 223 NHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281
Query: 255 NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDER 314
N F P L +IR + Q+ ++ L S L H DLKPENI+ V +++ R
Sbjct: 282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD---------PVRQPYR 332
Query: 315 TLINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 373
+KV+DFGSA++ + ST + +R+YRAPE+IL L + + D+WS+GC++ E +
Sbjct: 333 ------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF 386
Query: 374 LGFTVFPTHDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD--------RLDWDEH-- 422
LG+ ++P + + + + G ++++ T+ ++F+ D RL E
Sbjct: 387 LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHE 446
Query: 423 -------SSAGRYVSRRCKPLKEFMLSQDVE----------HERLFDLIQKMLEYDPAKR 465
A +Y+ + + +S D+E DL++KML D KR
Sbjct: 447 LETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKR 506
Query: 466 ITLREALKHPF 476
IT + L H F
Sbjct: 507 ITPLKTLNHQF 517
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 166 bits (419), Expect = 6e-41
Identities = 110/371 (29%), Positives = 187/371 (50%), Gaps = 49/371 (13%)
Query: 138 TRSVEDDEEGHLICQSGDVLSAR---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK 194
T+S EG ++L + YE+++ LG G FG+V +C ++ VA+KI+K
Sbjct: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILK 222
Query: 195 NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE 254
N Y + E+ +L L++ + + + V+ E F+H H C+VFE+L + YDF+K+
Sbjct: 223 NHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281
Query: 255 NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDER 314
N F P L +IR + Q+ ++ L S L H DLKPENI+ V +++ R
Sbjct: 282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD---------PVRQPYR 332
Query: 315 TLINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 373
+KV+DFGSA++ + ST + +R+YRAPE+IL L + + D+WS+GC++ E +
Sbjct: 333 ------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF 386
Query: 374 LGFTVFPTHDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD--------RLDWDEH-- 422
LG+ ++P + + + + G ++++ T+ ++F+ D RL E
Sbjct: 387 LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHE 446
Query: 423 -------SSAGRYVSRRCKPLKEFMLSQDVE----------HERLFDLIQKMLEYDPAKR 465
A +Y+ + + +S D+E DL++KML D KR
Sbjct: 447 LETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKR 506
Query: 466 ITLREALKHPF 476
IT + L H F
Sbjct: 507 ITPLKTLNHQF 517
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 162 bits (411), Expect = 5e-40
Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)
Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
YE++D LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255
Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
+ V+ E F+H H C+VFE+L + YDF+K+N F P L IR + Q+ ++ L
Sbjct: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314
Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
S L H DLKPENI+ V +++ R +KV+DFGSA++ + ST
Sbjct: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359
Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419
Query: 400 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 439
+ ++ K F D W +EH + A +Y+ +
Sbjct: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479
Query: 440 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
+L++ + L++KML D RIT E L HPF ++
Sbjct: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 162 bits (411), Expect = 5e-40
Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)
Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
YE++D LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255
Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
+ V+ E F+H H C+VFE+L + YDF+K+N F P L IR + Q+ ++ L
Sbjct: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314
Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
S L H DLKPENI+ V +++ R +KV+DFGSA++ + ST
Sbjct: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359
Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419
Query: 400 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 439
+ ++ K F D W +EH + A +Y+ +
Sbjct: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479
Query: 440 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
+L++ + L++KML D RIT E L HPF ++
Sbjct: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 159 bits (402), Expect = 5e-39
Identities = 105/352 (29%), Positives = 178/352 (50%), Gaps = 38/352 (10%)
Query: 144 DEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAA 203
D EG+ G+VL RY + G+G F VV D+ + VAVKI++N + +
Sbjct: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
Query: 204 RSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENG-FLPFRL 262
E++ L+ LN DP+ F C+++ F H H+C+VFE L ++ + +K+ G + +
Sbjct: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
+R + Q+ ++ L + H D+KP+NIL +S +T+ +K
Sbjct: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES--------------KTI----LK 831
Query: 323 VVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 380
+ DFGSA++ D++ LVS R YRAPE+I+ + D+WS+GC L E Y G +FP
Sbjct: 832 LCDFGSASHVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 890
Query: 381 THDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD----RLDWDEHSSAGRY-VSRRCK 434
+ L + + G +P MI+K K ++F + ++ D+ + + V
Sbjct: 891 GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN 950
Query: 435 PLKEFML----------SQDVEHERLFDLIQKMLEYDPAKRITLREALKHPF 476
P K+ + Q + +L DL+ ++L DPAKRI++ +AL+H F
Sbjct: 951 PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 145 bits (365), Expect = 1e-34
Identities = 99/356 (27%), Positives = 174/356 (48%), Gaps = 54/356 (15%)
Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
Y+I++ LG+G FG+V + ++ G VA+KI+KN ++E+++L + DP
Sbjct: 11 YDIIEVLGKGTFGEVAKGW-RRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
++ LE+F +VFELL + ++F KEN F P HIR + Q+ ++ L
Sbjct: 70 A-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHH---S 337
+ H DLKPENI+ V ++T +KV+DFGSA+ E
Sbjct: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173
Query: 338 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGP 397
+ +R YRAPE++L L + + DVWS+GC++ E +LG+ ++P ++ + + + G
Sbjct: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
Query: 398 LPKHMIQKTRKRKYF-----HHDRLD-WDEHSSAGRYVSRRCKPL--KEFM--------- 440
H++ K +F H D + W SSA + +PL +++M
Sbjct: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
Query: 441 -----------------LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
L++ + + + +LI++ML ++ +RI+ AL+HPF +
Sbjct: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSM 349
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 136 bits (343), Expect = 4e-32
Identities = 95/332 (28%), Positives = 163/332 (49%), Gaps = 49/332 (14%)
Query: 154 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL 213
G+V++ ++EI+ +GEGA+G V++C HK VA+K K+ + E + ++ L+ L
Sbjct: 7 GNVMN-KFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKML 64
Query: 214 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE--NGFLPFRLDHIRKMAYQ 271
T + V++ E F G + +VFE + + + ++E NG P + ++ YQ
Sbjct: 65 RTLKQENI---VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPP---EKVKSYIYQ 118
Query: 272 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 331
+ K++++ H N + H D+KPEN+L +D +K+ DFG A
Sbjct: 119 LIKAIHWCHKNDIVHRDIKPENLLISHNDV-------------------LKLCDFGFARN 159
Query: 332 DDE----HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 387
E +++ V+TR YR+PE++L + + D+WS+GCIL E G +FP +
Sbjct: 160 LSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ 219
Query: 388 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEH--SSAGRYVSRRCKPLKEFMLSQDV 445
L ++++LGPLP ++ FH R H S RY+ +
Sbjct: 220 LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLG--------------I 265
Query: 446 EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
+ L DL++ +L+ DPA R + L HP F
Sbjct: 266 LNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 136 bits (343), Expect = 4e-32
Identities = 95/332 (28%), Positives = 163/332 (49%), Gaps = 49/332 (14%)
Query: 154 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL 213
G+V++ ++EI+ +GEGA+G V++C HK VA+K K+ + E + ++ L+ L
Sbjct: 7 GNVMN-KFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKML 64
Query: 214 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE--NGFLPFRLDHIRKMAYQ 271
T + V++ E F G + +VFE + + + ++E NG P + ++ YQ
Sbjct: 65 RTLKQENI---VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPP---EKVKSYIYQ 118
Query: 272 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 331
+ K++++ H N + H D+KPEN+L +D +K+ DFG A
Sbjct: 119 LIKAIHWCHKNDIVHRDIKPENLLISHNDV-------------------LKLCDFGFARN 159
Query: 332 DDE----HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 387
E +++ V+TR YR+PE++L + + D+WS+GCIL E G +FP +
Sbjct: 160 LSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ 219
Query: 388 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEH--SSAGRYVSRRCKPLKEFMLSQDV 445
L ++++LGPLP ++ FH R H S RY+ +
Sbjct: 220 LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLG--------------I 265
Query: 446 EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
+ L DL++ +L+ DPA R + L HP F
Sbjct: 266 LNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 126 bits (316), Expect = 5e-29
Identities = 104/335 (31%), Positives = 163/335 (48%), Gaps = 53/335 (15%)
Query: 160 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTT 216
+YE V +GEGA+GKV + D K GGR VA+K V+ + + E+ VL HL T
Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71
Query: 217 DPNSTFRCVQM--LEWFEHHGHICIVFELLG--LSTY-DFIKENGFLPFRLDHIRKMAYQ 271
+ + R + + + + +VFE + L+TY D + E G + I+ M +Q
Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV---PTETIKDMMFQ 128
Query: 272 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT- 330
+ + ++FLHS+++ H DLKP+NIL S IK+ DFG A
Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSG-------------------QIKLADFGLARI 169
Query: 331 YDDEHHST-LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLA 389
Y + T +V T YRAPEV+L ++ P D+WS+GCI E + +F + L
Sbjct: 170 YSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229
Query: 390 MMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGR--YVSRRCKPLKEFMLSQDVEH 447
+ ++G LP DW + R + S+ +P+++F+ D
Sbjct: 230 KILDVIG-LP---------------GEEDWPRDVALPRQAFHSKSAQPIEKFVTDID--- 270
Query: 448 ERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 482
E DL+ K L ++PAKRI+ AL HP+F L++
Sbjct: 271 ELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,564,798
Number of Sequences: 37866
Number of extensions: 882240
Number of successful extensions: 5828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 537
Number of HSP's successfully gapped in prelim test: 330
Number of HSP's that attempted gapping in prelim test: 3054
Number of HSP's gapped (non-prelim): 1762
length of query: 484
length of database: 18,247,518
effective HSP length: 106
effective length of query: 378
effective length of database: 14,233,722
effective search space: 5380346916
effective search space used: 5380346916
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.