Guide to the Human Genome
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Search of human proteins with 67551261

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
         (484 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]              1021   0.0  
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]               1021   0.0  
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          791   0.0  
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          550   e-157
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               483   e-136
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]               483   e-136
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   213   4e-55
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   213   4e-55
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...   207   2e-53
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...   207   2e-53
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   203   2e-52
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...   184   1e-46
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...   184   2e-46
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...   178   1e-44
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...   172   8e-43
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...   172   8e-43
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...   172   8e-43
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...   172   8e-43
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...   172   8e-43
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...   171   1e-42
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...   171   1e-42
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...   166   6e-41
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...   166   6e-41
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...   162   5e-40
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...   162   5e-40
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      159   5e-39
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   145   1e-34
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]             136   4e-32
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]              136   4e-32
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 126   5e-29

>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score = 1021 bits (2641), Expect = 0.0
 Identities = 484/484 (100%), Positives = 484/484 (100%)

Query: 1   MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
           MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
Sbjct: 43  MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 102

Query: 61  SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 120
           SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
Sbjct: 103 SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 162

Query: 121 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 180
           HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
Sbjct: 163 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 222

Query: 181 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 240
           HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
Sbjct: 223 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 282

Query: 241 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 300
           FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
Sbjct: 283 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 342

Query: 301 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 360
           YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
Sbjct: 343 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 402

Query: 361 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 420
           DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
Sbjct: 403 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 462

Query: 421 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 480
           EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
Sbjct: 463 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 522

Query: 481 KKSI 484
           KKSI
Sbjct: 523 KKSI 526


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score = 1021 bits (2641), Expect = 0.0
 Identities = 484/484 (100%), Positives = 484/484 (100%)

Query: 1   MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
           MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
Sbjct: 1   MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60

Query: 61  SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 120
           SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
Sbjct: 61  SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH 120

Query: 121 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 180
           HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
Sbjct: 121 HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID 180

Query: 181 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 240
           HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
Sbjct: 181 HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV 240

Query: 241 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 300
           FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
Sbjct: 241 FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD 300

Query: 301 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 360
           YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
Sbjct: 301 YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC 360

Query: 361 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 420
           DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
Sbjct: 361 DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD 420

Query: 421 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 480
           EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
Sbjct: 421 EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 480

Query: 481 KKSI 484
           KKSI
Sbjct: 481 KKSI 484


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  791 bits (2044), Expect = 0.0
 Identities = 383/484 (79%), Positives = 422/484 (87%), Gaps = 6/484 (1%)

Query: 1   MRHSKRTYCPDWDDKD-WDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHS-KMCDSHYLE 58
           MRHSKRT+CPDWD ++ W +  +R S  HKR++RSHSS QEN+ CK +H  K  D HYLE
Sbjct: 1   MRHSKRTHCPDWDSRESWGHESYRGS--HKRKRRSHSSTQENRHCKPHHQFKESDCHYLE 58

Query: 59  SRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHR 118
           +RS+NE+DY  RRY+DEYRNDY +G  P H  RD ES Y+ H SKSS RS RSS K K R
Sbjct: 59  ARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRK-R 117

Query: 119 IHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVEC 178
             H +SH+ S  KSHRRKR+RS+EDDEEGHLICQSGDVL ARYEIVDTLGEGAFGKVVEC
Sbjct: 118 NRHCSSHQ-SRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVEC 176

Query: 179 IDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHIC 238
           IDH   G HVAVKIVKNV RY EAARSEIQVLEHLN+TDPNS FRCVQMLEWF+HHGH+C
Sbjct: 177 IDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVC 236

Query: 239 IVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQ 298
           IVFELLGLSTYDFIKEN FLPF++DHIR+MAYQIC+S+NFLH NKLTHTDLKPENILFV+
Sbjct: 237 IVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVK 296

Query: 299 SDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 358
           SDY   YN K+KRDERTL N DIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
Sbjct: 297 SDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 356

Query: 359 PCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLD 418
           PCDVWSIGCILIEYYLGFTVF THDSKEHLAMMERILGP+P+HMIQKTRKRKYFHH++LD
Sbjct: 357 PCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLD 416

Query: 419 WDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 478
           WDEHSSAGRYV RRCKPLKEFML  D EHE+LFDL+++MLEYDP +RITL EAL+HPFFD
Sbjct: 417 WDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476

Query: 479 LLKK 482
           LLKK
Sbjct: 477 LLKK 480


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  550 bits (1418), Expect = e-157
 Identities = 270/487 (55%), Positives = 349/487 (71%), Gaps = 11/487 (2%)

Query: 1   MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
           M H +R +  +   +      +RS    +RR RS SS+ +  R +       DS+++ SR
Sbjct: 1   MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRRE----DSYHVRSR 56

Query: 61  SI-----NEKDYHSRRYIDEYR-NDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYK 114
           S      +++  + RRY   YR NDY++     +   D+   Y+     SS RS RSS +
Sbjct: 57  SSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSS-R 115

Query: 115 SKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGK 174
            KHR     S   S   SH  +R +SVEDD EGHLI   GD L  RYEIV TLGEG FG+
Sbjct: 116 RKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175

Query: 175 VVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHH 234
           VV+C+DH+ GG  VA+KI+KNV++Y EAAR EI VLE +N  DP++   CVQM +WF++H
Sbjct: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235

Query: 235 GHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENI 294
           GH+CI FELLGLST+DF+K+N +LP+ +  +R MA+Q+C++V FLH NKLTHTDLKPENI
Sbjct: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENI 295

Query: 295 LFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILAL 354
           LFV SDY   YN + KRDER++ +  ++VVDFGSAT+D EHHST+VSTRHYRAPEVIL L
Sbjct: 296 LFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILEL 355

Query: 355 GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHH 414
           GWSQPCDVWSIGCI+ EYY+GFT+F THD++EHLAMMERILGP+P  MI+KTRK+KYF+ 
Sbjct: 356 GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYR 415

Query: 415 DRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 474
            RLDWDE++SAGRYV   CKPL+ ++ S+  EH +LFDLI+ MLEY+PAKR+TL EAL+H
Sbjct: 416 GRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQH 475

Query: 475 PFFDLLK 481
           PFF  L+
Sbjct: 476 PFFARLR 482


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  483 bits (1244), Expect = e-136
 Identities = 248/484 (51%), Positives = 318/484 (65%), Gaps = 19/484 (3%)

Query: 1   MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
           M H KR   P+ D     Y  +R      +R+RS+S   E  R +Y   +        SR
Sbjct: 149 MHHCKRYRSPEPDP----YLSYRW-----KRRRSYSREHEG-RLRYPSRREPPPRRSRSR 198

Query: 61  SINEKDYHSRRYIDEYRNDYTQGCE---PGHRQRDHESRYQNHSSKSSGRSGRSSYKSKH 117
           S +   Y  RRY  E R+  T  CE   P   +  +      H  +S  R    + K  H
Sbjct: 199 SHDRLPYQ-RRY-RERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAH 256

Query: 118 RIH----HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFG 173
             H     S S   S  +   ++ +RSVEDD+EGHL+C+ GD L  RYEIV  LGEG FG
Sbjct: 257 HCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFG 316

Query: 174 KVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEH 233
           KVVEC+DH  G   VA+KI++NV +Y EAAR EI VL+ +   D  + F CV M +WF  
Sbjct: 317 KVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF 376

Query: 234 HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPEN 293
           HGH+CI FELLG +T++F+KEN F P+ L H+R MAYQ+C ++ FLH N+LTHTDLKPEN
Sbjct: 377 HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 436

Query: 294 ILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 353
           ILFV S++   YN     +E+++ N  I+V DFGSAT+D EHH+T+V+TRHYR PEVIL 
Sbjct: 437 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 496

Query: 354 LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFH 413
           LGW+QPCDVWSIGCIL EYY GFT+F TH+++EHL MME+ILGP+P HMI +TRK+KYF+
Sbjct: 497 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY 556

Query: 414 HDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALK 473
              L WDE+SS GRYV   CKPLK +ML   +EH +LFDL+++MLE+DPA+RITL EAL 
Sbjct: 557 KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALL 616

Query: 474 HPFF 477
           HPFF
Sbjct: 617 HPFF 620


>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
          Length = 490

 Score =  483 bits (1244), Expect = e-136
 Identities = 248/484 (51%), Positives = 318/484 (65%), Gaps = 19/484 (3%)

Query: 1   MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
           M H KR   P+ D     Y  +R      +R+RS+S   E  R +Y   +        SR
Sbjct: 1   MHHCKRYRSPEPDP----YLSYRW-----KRRRSYSREHEG-RLRYPSRREPPPRRSRSR 50

Query: 61  SINEKDYHSRRYIDEYRNDYTQGCE---PGHRQRDHESRYQNHSSKSSGRSGRSSYKSKH 117
           S +   Y  RRY  E R+  T  CE   P   +  +      H  +S  R    + K  H
Sbjct: 51  SHDRLPYQ-RRY-RERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAH 108

Query: 118 RIH----HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFG 173
             H     S S   S  +   ++ +RSVEDD+EGHL+C+ GD L  RYEIV  LGEG FG
Sbjct: 109 HCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFG 168

Query: 174 KVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEH 233
           KVVEC+DH  G   VA+KI++NV +Y EAAR EI VL+ +   D  + F CV M +WF  
Sbjct: 169 KVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF 228

Query: 234 HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPEN 293
           HGH+CI FELLG +T++F+KEN F P+ L H+R MAYQ+C ++ FLH N+LTHTDLKPEN
Sbjct: 229 HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 288

Query: 294 ILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 353
           ILFV S++   YN     +E+++ N  I+V DFGSAT+D EHH+T+V+TRHYR PEVIL 
Sbjct: 289 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 348

Query: 354 LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFH 413
           LGW+QPCDVWSIGCIL EYY GFT+F TH+++EHL MME+ILGP+P HMI +TRK+KYF+
Sbjct: 349 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY 408

Query: 414 HDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALK 473
              L WDE+SS GRYV   CKPLK +ML   +EH +LFDL+++MLE+DPA+RITL EAL 
Sbjct: 409 KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALL 468

Query: 474 HPFF 477
           HPFF
Sbjct: 469 HPFF 472


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  213 bits (541), Expect = 4e-55
 Identities = 126/351 (35%), Positives = 193/351 (54%), Gaps = 37/351 (10%)

Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
           DD++G  +    D ++ RYE++  +G+G+FG+VV+  DHK   +HVA+K+V+N  R+   
Sbjct: 204 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 262

Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
           A  EI++LEHL   D ++T   + MLE F    HIC+ FELL ++ Y+ IK+N F  F L
Sbjct: 263 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 322

Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
             +RK A+ I + ++ LH N++ H DLKPENIL  Q                      IK
Sbjct: 323 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-----------------RSGIK 365

Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
           V+DFGS+ Y+ +   T + +R YRAPEVIL   +  P D+WS+GCIL E   G+ + P  
Sbjct: 366 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 425

Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDR-----------LDWDEHSSAGRYVSR 431
           D  + LA M  +LG   + ++  +++ K F   +            D     + GR  SR
Sbjct: 426 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR--SR 483

Query: 432 RCK-----PLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
           R K       +E+  +     + LF D +++ LE+DPA R+T  +AL+HP+
Sbjct: 484 RGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 534


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  213 bits (541), Expect = 4e-55
 Identities = 126/351 (35%), Positives = 193/351 (54%), Gaps = 37/351 (10%)

Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
           DD++G  +    D ++ RYE++  +G+G+FG+VV+  DHK   +HVA+K+V+N  R+   
Sbjct: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189

Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
           A  EI++LEHL   D ++T   + MLE F    HIC+ FELL ++ Y+ IK+N F  F L
Sbjct: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249

Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
             +RK A+ I + ++ LH N++ H DLKPENIL  Q                      IK
Sbjct: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-----------------RSGIK 292

Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
           V+DFGS+ Y+ +   T + +R YRAPEVIL   +  P D+WS+GCIL E   G+ + P  
Sbjct: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352

Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDR-----------LDWDEHSSAGRYVSR 431
           D  + LA M  +LG   + ++  +++ K F   +            D     + GR  SR
Sbjct: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR--SR 410

Query: 432 RCK-----PLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
           R K       +E+  +     + LF D +++ LE+DPA R+T  +AL+HP+
Sbjct: 411 RGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 461


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score =  207 bits (527), Expect = 2e-53
 Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)

Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
           DD +G  I    D L+ RYE++  +G+G+FG+V    DHK   ++VA+K+V+N  R+   
Sbjct: 171 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 229

Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
           A  EI++LEHL   D   +   + MLE F    H+C+ FELL +  Y+ IK+N F  F +
Sbjct: 230 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 289

Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
             +RK A  I +S++ LH NK+ H DLKPENIL             +K   R+      K
Sbjct: 290 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 332

Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
           V+DFGS+ ++ +   T + +R YRAPE+IL   +S P D+WS GCIL E   G  +FP  
Sbjct: 333 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 392

Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 433
           D  + LA M  +LG  P  +++++++ KYF +     R       + GR V     SRR 
Sbjct: 393 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 452

Query: 434 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
           K       K++  +     + LF + +++ L +DP+ R+T  +AL+HP+
Sbjct: 453 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 501


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score =  207 bits (527), Expect = 2e-53
 Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)

Query: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
           DD +G  I    D L+ RYE++  +G+G+FG+V    DHK   ++VA+K+V+N  R+   
Sbjct: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249

Query: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
           A  EI++LEHL   D   +   + MLE F    H+C+ FELL +  Y+ IK+N F  F +
Sbjct: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309

Query: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
             +RK A  I +S++ LH NK+ H DLKPENIL             +K   R+      K
Sbjct: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 352

Query: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
           V+DFGS+ ++ +   T + +R YRAPE+IL   +S P D+WS GCIL E   G  +FP  
Sbjct: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412

Query: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 433
           D  + LA M  +LG  P  +++++++ KYF +     R       + GR V     SRR 
Sbjct: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472

Query: 434 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
           K       K++  +     + LF + +++ L +DP+ R+T  +AL+HP+
Sbjct: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  203 bits (517), Expect = 2e-52
 Identities = 112/339 (33%), Positives = 183/339 (53%), Gaps = 20/339 (5%)

Query: 136 KRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN 195
           K +++  DDE G  +    D ++ RYE+++T+G+G+FG+V +C+DHK     VA+KI++N
Sbjct: 79  KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHK-NNELVALKIIRN 137

Query: 196 VDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKEN 255
             R+ + A  E+++LE L   D ++T+  V M ++F    H CI FELLG++ Y+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197

Query: 256 GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERT 315
            F  F L  +R+    + K +  L   K+ H DLKPENI+  Q                 
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG--------------- 242

Query: 316 LINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG 375
                +KV+DFGS+ Y+ +   T + +R YR+PEVIL   +    D+WS+GCI  E Y G
Sbjct: 243 --QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300

Query: 376 FTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKP 435
           + +FP  +  E LA +  +LG  P   IQ   +R+ F  D   + ++ +  R   +R   
Sbjct: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTF-FDSKGFPKNITNNR-GKKRYPD 358

Query: 436 LKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 474
            K+  +          D +++ L ++P+ R+T  +ALKH
Sbjct: 359 SKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKH 397


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score =  184 bits (468), Expect = 1e-46
 Identities = 121/377 (32%), Positives = 192/377 (50%), Gaps = 51/377 (13%)

Query: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
           +YK  + ++++   RR        S  K  ++      +DD   +++ +SG+    RYEI
Sbjct: 55  TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113

Query: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
              +G+G+FG+VV+  DH+     VA+KI+KN   +   A+ E+++LE +N  D    + 
Sbjct: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172

Query: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
            V +   F    H+C+VFELL  + YD ++   F    L+  RK+A Q+C ++ FL + +
Sbjct: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232

Query: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
           L+  H DLKPENIL          NPK            IK+VDFGS+    +     + 
Sbjct: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275

Query: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
           +R YR+PEV+L   +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P  
Sbjct: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335

Query: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEY 460
           M+ Q  + RKYF        E    G +  RR K L++             DL+ +MLEY
Sbjct: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRK-------------DLVLRMLEY 374

Query: 461 DPAKRITLREALKHPFF 477
           +PA RI+   AL+H FF
Sbjct: 375 EPAARISPLGALQHGFF 391


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score =  184 bits (467), Expect = 2e-46
 Identities = 121/377 (32%), Positives = 193/377 (51%), Gaps = 39/377 (10%)

Query: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
           +YK  + ++++   RR        S  K  ++      +DD   +++ +SG+    RYEI
Sbjct: 55  TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113

Query: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
              +G+G+FG+VV+  DH+     VA+KI+KN   +   A+ E+++LE +N  D    + 
Sbjct: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172

Query: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
            V +   F    H+C+VFELL  + YD ++   F    L+  RK+A Q+C ++ FL + +
Sbjct: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232

Query: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
           L+  H DLKPENIL          NPK            IK+VDFGS+    +     + 
Sbjct: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275

Query: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
           +R YR+PEV+L   +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P  
Sbjct: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335

Query: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEY 460
           M+ Q  + RKYF        E    G +  RR K L++          +  DL+ +MLEY
Sbjct: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLEY 386

Query: 461 DPAKRITLREALKHPFF 477
           +PA RI+   AL+H FF
Sbjct: 387 EPAARISPLGALQHGFF 403


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score =  178 bits (451), Expect = 1e-44
 Identities = 124/404 (30%), Positives = 198/404 (49%), Gaps = 65/404 (16%)

Query: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
           +YK  + ++++   RR        S  K  ++      +DD   +++ +SG+    RYEI
Sbjct: 55  TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113

Query: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
              +G+G+FG+VV+  DH+     VA+KI+KN   +   A+ E+++LE +N  D    + 
Sbjct: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172

Query: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
            V +   F    H+C+VFELL  + YD ++   F    L+  RK+A Q+C ++ FL + +
Sbjct: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232

Query: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
           L+  H DLKPENIL          NPK            IK+VDFGS+    +     + 
Sbjct: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275

Query: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
           +R YR+PEV+L   +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P  
Sbjct: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335

Query: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLS------QDV--------- 445
           M+ Q  + RKYF        E    G +  RR K L++          Q+V         
Sbjct: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPG 387

Query: 446 ------------EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
                       ++ R  DL+ +MLEY+PA RI+   AL+H FF
Sbjct: 388 GRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score =  172 bits (435), Expect = 8e-43
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162

Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221

Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281

Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324

Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384

Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444

Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score =  172 bits (435), Expect = 8e-43
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162

Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221

Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281

Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324

Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384

Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444

Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score =  172 bits (435), Expect = 8e-43
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162

Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221

Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281

Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324

Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384

Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444

Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score =  172 bits (435), Expect = 8e-43
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 94  TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 153

Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 154 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 212

Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 213 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 272

Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 273 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 315

Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 316 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 375

Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 376 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 435

Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 436 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score =  172 bits (435), Expect = 8e-43
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162

Query: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221

Query: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281

Query: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324

Query: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384

Query: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444

Query: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479


>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
           [Homo sapiens]
          Length = 1171

 Score =  171 bits (434), Expect = 1e-42
 Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)

Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
           YE+++ LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T   + 
Sbjct: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257

Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L +IR +  Q+  ++  L 
Sbjct: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316

Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
           S  L H DLKPENI+ V     + Y               +KV+DFGSA++  +   ST 
Sbjct: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361

Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421

Query: 400 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 441
           ++++   T+  ++F+ D       W     D+H +        A +Y+      + +  +
Sbjct: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481

Query: 442 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 476
           + D+E               DL++KML  D  KRIT  E L HPF
Sbjct: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
           [Homo sapiens]
          Length = 1198

 Score =  171 bits (434), Expect = 1e-42
 Identities = 108/345 (31%), Positives = 178/345 (51%), Gaps = 46/345 (13%)

Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
           YE+++ LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T   + 
Sbjct: 199 YEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD 257

Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L +IR +  Q+  ++  L 
Sbjct: 258 -YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316

Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
           S  L H DLKPENI+ V     + Y               +KV+DFGSA++  +   ST 
Sbjct: 317 SLGLIHADLKPENIMLVDPS-RQPYR--------------VKVIDFGSASHVSKAVCSTY 361

Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421

Query: 400 KHMIQK-TRKRKYFHHDRLD----W-----DEHSS--------AGRYVSRRCKPLKEFML 441
           ++++   T+  ++F+ D       W     D+H +        A +Y+      + +  +
Sbjct: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481

Query: 442 SQDVE----------HERLFDLIQKMLEYDPAKRITLREALKHPF 476
           + D+E               DL++KML  D  KRIT  E L HPF
Sbjct: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
           [Homo sapiens]
          Length = 1210

 Score =  166 bits (419), Expect = 6e-41
 Identities = 110/371 (29%), Positives = 187/371 (50%), Gaps = 49/371 (13%)

Query: 138 TRSVEDDEEGHLICQSGDVLSAR---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK 194
           T+S     EG       ++L +    YE+++ LG G FG+V +C   ++    VA+KI+K
Sbjct: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILK 222

Query: 195 NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE 254
           N   Y    + E+ +L  L++ + +  +  V+  E F+H  H C+VFE+L  + YDF+K+
Sbjct: 223 NHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281

Query: 255 NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDER 314
           N F P  L +IR +  Q+  ++  L S  L H DLKPENI+ V           +++  R
Sbjct: 282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD---------PVRQPYR 332

Query: 315 TLINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 373
                 +KV+DFGSA++  +   ST + +R+YRAPE+IL L + +  D+WS+GC++ E +
Sbjct: 333 ------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF 386

Query: 374 LGFTVFPTHDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD--------RLDWDEH-- 422
           LG+ ++P     + +  + +  G   ++++   T+  ++F+ D        RL   E   
Sbjct: 387 LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHE 446

Query: 423 -------SSAGRYVSRRCKPLKEFMLSQDVE----------HERLFDLIQKMLEYDPAKR 465
                    A +Y+      + +  +S D+E               DL++KML  D  KR
Sbjct: 447 LETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKR 506

Query: 466 ITLREALKHPF 476
           IT  + L H F
Sbjct: 507 ITPLKTLNHQF 517


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
           [Homo sapiens]
          Length = 1075

 Score =  166 bits (419), Expect = 6e-41
 Identities = 110/371 (29%), Positives = 187/371 (50%), Gaps = 49/371 (13%)

Query: 138 TRSVEDDEEGHLICQSGDVLSAR---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK 194
           T+S     EG       ++L +    YE+++ LG G FG+V +C   ++    VA+KI+K
Sbjct: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILK 222

Query: 195 NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE 254
           N   Y    + E+ +L  L++ + +  +  V+  E F+H  H C+VFE+L  + YDF+K+
Sbjct: 223 NHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281

Query: 255 NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDER 314
           N F P  L +IR +  Q+  ++  L S  L H DLKPENI+ V           +++  R
Sbjct: 282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD---------PVRQPYR 332

Query: 315 TLINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 373
                 +KV+DFGSA++  +   ST + +R+YRAPE+IL L + +  D+WS+GC++ E +
Sbjct: 333 ------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF 386

Query: 374 LGFTVFPTHDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD--------RLDWDEH-- 422
           LG+ ++P     + +  + +  G   ++++   T+  ++F+ D        RL   E   
Sbjct: 387 LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHE 446

Query: 423 -------SSAGRYVSRRCKPLKEFMLSQDVE----------HERLFDLIQKMLEYDPAKR 465
                    A +Y+      + +  +S D+E               DL++KML  D  KR
Sbjct: 447 LETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKR 506

Query: 466 ITLREALKHPF 476
           IT  + L H F
Sbjct: 507 ITPLKTLNHQF 517


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
           [Homo sapiens]
          Length = 1194

 Score =  162 bits (411), Expect = 5e-40
 Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)

Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
           YE++D LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T + + 
Sbjct: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255

Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L  IR +  Q+  ++  L 
Sbjct: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314

Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
           S  L H DLKPENI+ V           +++  R      +KV+DFGSA++  +   ST 
Sbjct: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359

Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419

Query: 400 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 439
           + ++    K   F     D     W     +EH +        A +Y+      +     
Sbjct: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479

Query: 440 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
                   +L++  +      L++KML  D   RIT  E L HPF ++
Sbjct: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527


>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
           [Homo sapiens]
          Length = 1215

 Score =  162 bits (411), Expect = 5e-40
 Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)

Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
           YE++D LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T + + 
Sbjct: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255

Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L  IR +  Q+  ++  L 
Sbjct: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314

Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
           S  L H DLKPENI+ V           +++  R      +KV+DFGSA++  +   ST 
Sbjct: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359

Query: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419

Query: 400 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 439
           + ++    K   F     D     W     +EH +        A +Y+      +     
Sbjct: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479

Query: 440 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
                   +L++  +      L++KML  D   RIT  E L HPF ++
Sbjct: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  159 bits (402), Expect = 5e-39
 Identities = 105/352 (29%), Positives = 178/352 (50%), Gaps = 38/352 (10%)

Query: 144  DEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAA 203
            D EG+     G+VL  RY +    G+G F  VV   D+    + VAVKI++N +   +  
Sbjct: 670  DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729

Query: 204  RSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENG-FLPFRL 262
              E++ L+ LN  DP+  F C+++   F H  H+C+VFE L ++  + +K+ G  +   +
Sbjct: 730  LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789

Query: 263  DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
              +R  + Q+  ++  L    + H D+KP+NIL  +S              +T+    +K
Sbjct: 790  KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES--------------KTI----LK 831

Query: 323  VVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 380
            + DFGSA++  D++    LVS R YRAPE+I+   +    D+WS+GC L E Y G  +FP
Sbjct: 832  LCDFGSASHVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 890

Query: 381  THDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD----RLDWDEHSSAGRY-VSRRCK 434
               +   L +   + G +P  MI+K   K ++F  +     ++ D+ +   +  V     
Sbjct: 891  GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN 950

Query: 435  PLKEFML----------SQDVEHERLFDLIQKMLEYDPAKRITLREALKHPF 476
            P K+ +            Q  +  +L DL+ ++L  DPAKRI++ +AL+H F
Sbjct: 951  PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  145 bits (365), Expect = 1e-34
 Identities = 99/356 (27%), Positives = 174/356 (48%), Gaps = 54/356 (15%)

Query: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
           Y+I++ LG+G FG+V +    ++ G  VA+KI+KN        ++E+++L  +   DP  
Sbjct: 11  YDIIEVLGKGTFGEVAKGW-RRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69

Query: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
               ++ LE+F       +VFELL  + ++F KEN F P    HIR +  Q+  ++  L 
Sbjct: 70  A-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128

Query: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHH---S 337
              + H DLKPENI+ V               ++T     +KV+DFGSA+   E      
Sbjct: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173

Query: 338 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGP 397
             + +R YRAPE++L L + +  DVWS+GC++ E +LG+ ++P ++  + +  +    G 
Sbjct: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233

Query: 398 LPKHMIQKTRKRKYF-----HHDRLD-WDEHSSAGRYVSRRCKPL--KEFM--------- 440
              H++    K  +F     H D  + W   SSA      + +PL  +++M         
Sbjct: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293

Query: 441 -----------------LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
                            L++  + + + +LI++ML ++  +RI+   AL+HPF  +
Sbjct: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSM 349


>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  136 bits (343), Expect = 4e-32
 Identities = 95/332 (28%), Positives = 163/332 (49%), Gaps = 49/332 (14%)

Query: 154 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL 213
           G+V++ ++EI+  +GEGA+G V++C  HK     VA+K  K+ +   E   + ++ L+ L
Sbjct: 7   GNVMN-KFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKML 64

Query: 214 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE--NGFLPFRLDHIRKMAYQ 271
            T    +    V++ E F   G + +VFE +  +  + ++E  NG  P   + ++   YQ
Sbjct: 65  RTLKQENI---VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPP---EKVKSYIYQ 118

Query: 272 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 331
           + K++++ H N + H D+KPEN+L   +D                    +K+ DFG A  
Sbjct: 119 LIKAIHWCHKNDIVHRDIKPENLLISHNDV-------------------LKLCDFGFARN 159

Query: 332 DDE----HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 387
             E    +++  V+TR YR+PE++L   + +  D+WS+GCIL E   G  +FP     + 
Sbjct: 160 LSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ 219

Query: 388 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEH--SSAGRYVSRRCKPLKEFMLSQDV 445
           L  ++++LGPLP   ++       FH  R     H  S   RY+               +
Sbjct: 220 LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLG--------------I 265

Query: 446 EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
            +  L DL++ +L+ DPA R    + L HP F
Sbjct: 266 LNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297


>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  136 bits (343), Expect = 4e-32
 Identities = 95/332 (28%), Positives = 163/332 (49%), Gaps = 49/332 (14%)

Query: 154 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL 213
           G+V++ ++EI+  +GEGA+G V++C  HK     VA+K  K+ +   E   + ++ L+ L
Sbjct: 7   GNVMN-KFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKML 64

Query: 214 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE--NGFLPFRLDHIRKMAYQ 271
            T    +    V++ E F   G + +VFE +  +  + ++E  NG  P   + ++   YQ
Sbjct: 65  RTLKQENI---VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPP---EKVKSYIYQ 118

Query: 272 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 331
           + K++++ H N + H D+KPEN+L   +D                    +K+ DFG A  
Sbjct: 119 LIKAIHWCHKNDIVHRDIKPENLLISHNDV-------------------LKLCDFGFARN 159

Query: 332 DDE----HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 387
             E    +++  V+TR YR+PE++L   + +  D+WS+GCIL E   G  +FP     + 
Sbjct: 160 LSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ 219

Query: 388 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEH--SSAGRYVSRRCKPLKEFMLSQDV 445
           L  ++++LGPLP   ++       FH  R     H  S   RY+               +
Sbjct: 220 LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLG--------------I 265

Query: 446 EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
            +  L DL++ +L+ DPA R    + L HP F
Sbjct: 266 LNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  126 bits (316), Expect = 5e-29
 Identities = 104/335 (31%), Positives = 163/335 (48%), Gaps = 53/335 (15%)

Query: 160 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTT 216
           +YE V  +GEGA+GKV +  D K GGR VA+K V+     +    +   E+ VL HL T 
Sbjct: 12  QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71

Query: 217 DPNSTFRCVQM--LEWFEHHGHICIVFELLG--LSTY-DFIKENGFLPFRLDHIRKMAYQ 271
           +  +  R   +  +   +    + +VFE +   L+TY D + E G      + I+ M +Q
Sbjct: 72  EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV---PTETIKDMMFQ 128

Query: 272 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT- 330
           + + ++FLHS+++ H DLKP+NIL   S                     IK+ DFG A  
Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSG-------------------QIKLADFGLARI 169

Query: 331 YDDEHHST-LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLA 389
           Y  +   T +V T  YRAPEV+L   ++ P D+WS+GCI  E +    +F      + L 
Sbjct: 170 YSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229

Query: 390 MMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGR--YVSRRCKPLKEFMLSQDVEH 447
            +  ++G LP                  DW    +  R  + S+  +P+++F+   D   
Sbjct: 230 KILDVIG-LP---------------GEEDWPRDVALPRQAFHSKSAQPIEKFVTDID--- 270

Query: 448 ERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 482
           E   DL+ K L ++PAKRI+   AL HP+F  L++
Sbjct: 271 ELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,564,798
Number of Sequences: 37866
Number of extensions: 882240
Number of successful extensions: 5828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 537
Number of HSP's successfully gapped in prelim test: 330
Number of HSP's that attempted gapping in prelim test: 3054
Number of HSP's gapped (non-prelim): 1762
length of query: 484
length of database: 18,247,518
effective HSP length: 106
effective length of query: 378
effective length of database: 14,233,722
effective search space: 5380346916
effective search space used: 5380346916
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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