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Search of human proteins with 65287717
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65287717 eukaryotic translation initiation factor 2 alpha
kinase 4 [Homo sapiens]
(1649 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 3295 0.0
gi|134304838 eukaryotic translation initiation factor 2-alpha ki... 171 4e-42
gi|197245437 eukaryotic translation initiation factor 2-alpha ki... 167 6e-41
gi|11125768 eukaryotic translation initiation factor 2-alpha kin... 167 1e-40
gi|6996014 histidyl-tRNA synthetase [Homo sapiens] 142 2e-33
gi|15029520 histidyl-tRNA synthetase 2 precursor [Homo sapiens] 119 2e-26
gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 115 5e-25
gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 115 5e-25
gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 115 5e-25
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 100 9e-21
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 99 3e-20
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 96 3e-19
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 94 1e-18
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 94 1e-18
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 93 2e-18
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 92 4e-18
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 91 1e-17
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 90 2e-17
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 90 2e-17
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 90 2e-17
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 89 4e-17
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 89 4e-17
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 89 4e-17
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 89 5e-17
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 89 5e-17
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 87 1e-16
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 87 1e-16
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 87 1e-16
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 87 1e-16
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 86 3e-16
>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4
[Homo sapiens]
Length = 1649
Score = 3295 bits (8543), Expect = 0.0
Identities = 1649/1649 (100%), Positives = 1649/1649 (100%)
Query: 1 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY 60
MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
Sbjct: 1 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY 60
Query: 61 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE 120
PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
Sbjct: 61 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE 120
Query: 121 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ 180
VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
Sbjct: 121 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ 180
Query: 181 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR 240
RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
Sbjct: 181 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR 240
Query: 241 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL 300
ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
Sbjct: 241 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL 300
Query: 301 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR 360
ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
Sbjct: 301 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR 360
Query: 361 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS 420
YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
Sbjct: 361 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS 420
Query: 421 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD 480
VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
Sbjct: 421 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD 480
Query: 481 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN 540
VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
Sbjct: 481 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN 540
Query: 541 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA 600
PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
Sbjct: 541 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA 600
Query: 601 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE 660
FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
Sbjct: 601 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE 660
Query: 661 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS 720
RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
Sbjct: 661 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS 720
Query: 721 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK 780
ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
Sbjct: 721 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK 780
Query: 781 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH 840
NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
Sbjct: 781 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH 840
Query: 841 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG 900
EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
Sbjct: 841 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG 900
Query: 901 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP 960
MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
Sbjct: 901 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP 960
Query: 961 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT 1020
KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
Sbjct: 961 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT 1020
Query: 1021 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA 1080
NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
Sbjct: 1021 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA 1080
Query: 1081 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE 1140
VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
Sbjct: 1081 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE 1140
Query: 1141 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL 1200
RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
Sbjct: 1141 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL 1200
Query: 1201 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF 1260
NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
Sbjct: 1201 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF 1260
Query: 1261 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK 1320
IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
Sbjct: 1261 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK 1320
Query: 1321 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK 1380
VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
Sbjct: 1321 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK 1380
Query: 1381 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ 1440
ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
Sbjct: 1381 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ 1440
Query: 1441 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG 1500
EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
Sbjct: 1441 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG 1500
Query: 1501 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT 1560
REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
Sbjct: 1501 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT 1560
Query: 1561 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC 1620
SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
Sbjct: 1561 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC 1620
Query: 1621 DEIYNIKVEKKVSVLFLYSYRDDYYRILF 1649
DEIYNIKVEKKVSVLFLYSYRDDYYRILF
Sbjct: 1621 DEIYNIKVEKKVSVLFLYSYRDDYYRILF 1649
>gi|134304838 eukaryotic translation initiation factor 2-alpha kinase
3 [Homo sapiens]
Length = 1116
Score = 171 bits (434), Expect = 4e-42
Identities = 147/505 (29%), Positives = 219/505 (43%), Gaps = 107/505 (21%)
Query: 584 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRL 643
SRY +FE +Q LG+G FG V + +NK+D C YA+KRI + ++ EV L++L
Sbjct: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 646
Query: 644 HHENIVRYYNAWIERHERP----------AGPGTPPPDSGPLAKDDRAARGQPASDTDGL 693
H IVRY+NAW+E T P S P D + + +
Sbjct: 647 EHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATK 706
Query: 694 DSVEAAAPPPILSSSVEWSTSGERSASA--RFPATGPGSSDDEDDDEDEHGGVFSQ-SFL 750
+ +E AP P S S S ++++S+ +F D ED E Q S L
Sbjct: 707 EHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCL 766
Query: 751 PASDSESDIIFDNED------------------ENSKSQNQDEDCNEKNGCHESEPSV-- 790
D E + N++ E + S ED N + EP
Sbjct: 767 TDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNR 826
Query: 791 --------------------------------------------TTEAVH------YLYI 800
TTE + YLYI
Sbjct: 827 LHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYI 886
Query: 801 QMEYCEKSTLRD------TIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNI 854
QM+ C K L+D TI++ R+ +F +I + + ++H KG++HRDLKP NI
Sbjct: 887 QMQLCRKENLKDWMNGRCTIEE---RERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
Query: 855 FLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPE-VQ 913
F DD VK+GDFGL T + D +++QT L TG VGT LY+SPE +
Sbjct: 944 FFTMDDVVKVGDFGLVT-----AMDQDEEEQT-VLTPMPAYARHTGQVGTKLYMSPEQIH 997
Query: 914 GSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAK 973
G ++Y+ KVD+FSLG+I FE+ Y P T ER+ L +R + KFP F ++
Sbjct: 998 G---NSYSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVR---NLKFPPLFTQ-KYPC 1049
Query: 974 QKSVISWLLNHDPAKRPTATELLKS 998
+ ++ +L+ P +RP A ++++
Sbjct: 1050 EYVMVQDMLSPSPMERPEAINIIEN 1074
Score = 32.7 bits (73), Expect = 3.0
Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 4/55 (7%)
Query: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT 462
Q+ +++LHS ++H+ L SN+ + VK+ D+ L +D EQT
Sbjct: 920 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFG----LVTAMDQDEEEQT 970
>gi|197245437 eukaryotic translation initiation factor 2-alpha kinase
1 isoform b [Homo sapiens]
Length = 629
Score = 167 bits (424), Expect = 6e-41
Identities = 158/476 (33%), Positives = 228/476 (47%), Gaps = 48/476 (10%)
Query: 550 QSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQN 609
+S ++ QD E + ++ S E Q SRY EFEEL +LGKG +G V KV+N
Sbjct: 129 RSAKERVRQDPCEDISRIQKIRSREVALEAQT--SRYLNEFEELAILGKGGYGRVYKVRN 186
Query: 610 KLDGCCYAVKRIPINPASRQF-RRIKGEVTLLSRLHHENIVRYYNAWIERHE--RPAGPG 666
KLDG YA+K+I I A++ ++ EV +L+ L H NIV Y+ AWIE +P
Sbjct: 187 KLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRDRA 246
Query: 667 TPPPDSGPLAKDDRAARGQ--PASDTDGLDSVEAAAPPPILSSSV-EWSTSGERSASARF 723
S + D R Q +D S+ A P P E T + + S ++
Sbjct: 247 AIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKY 306
Query: 724 PA--TGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKN 781
S + E E + G+ S +S E + +S E+ +E+N
Sbjct: 307 TTNLVIRESGELESTLELQENGLAGLS--ASSIVEQQLPLRRNSHLEESFTSTEESSEEN 364
Query: 782 GCHESEPSVTTEAVHY--LYIQMEYCEKSTL----------RDTIDQGL--YRDTVRLWR 827
+ TEA ++ L+IQM+ CE S R+ +D+ Y +
Sbjct: 365 VNFLGQ----TEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATK 420
Query: 828 LFREILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLA-TDHLAFSADSKQDDQ 885
+F+E+++G+ YIH G++HRDLKP NIFL D VKIGDFGLA TD L K D
Sbjct: 421 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL-----QKNTDW 475
Query: 886 TGDLIKSDPSGHLTGMVGTALYVSPE-VQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTA 944
T K P+ T VGT LY SPE ++G S Y+ K D++SLG++ E+ + P T
Sbjct: 476 TNRNGKRTPTH--TSRVGTCLYASPEQLEG---SEYDAKSDMYSLGVVLLEL-FQPFGTE 529
Query: 945 SERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSEL 1000
ER VL LR + + PE Q I L + ++RP+A +LL+SEL
Sbjct: 530 MERAEVLTGLR---TGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 581
Score = 33.1 bits (74), Expect = 2.3
Identities = 41/185 (22%), Positives = 78/185 (42%), Gaps = 39/185 (21%)
Query: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADICKEDV-------- 458
+L+ G+ Y+H+ +VH+ L N+ + + VKI D+ ++ DI +++
Sbjct: 424 ELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA--CTDILQKNTDWTNRNGK 481
Query: 459 ---FEQTRVRFSDNALPYKT-----GKKGDVWRLGLLLLSLSQ-------------GQEC 497
+RV A P + K D++ LG++LL L Q G
Sbjct: 482 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRT 541
Query: 498 GEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF------INPQPKMPLVEQS 551
G+ P ++ P + +++ + +R S QLL+ +N +M ++EQ
Sbjct: 542 GQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 600
Query: 552 PEDSE 556
E +E
Sbjct: 601 KEIAE 605
>gi|11125768 eukaryotic translation initiation factor 2-alpha kinase 1
isoform a [Homo sapiens]
Length = 630
Score = 167 bits (422), Expect = 1e-40
Identities = 157/478 (32%), Positives = 230/478 (48%), Gaps = 51/478 (10%)
Query: 550 QSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQN 609
+S ++ QD E + ++ S E Q SRY EFEEL +LGKG +G V KV+N
Sbjct: 129 RSAKERVRQDPCEDISRIQKIRSREVALEAQT--SRYLNEFEELAILGKGGYGRVYKVRN 186
Query: 610 KLDGCCYAVKRIPINPASRQF-RRIKGEVTLLSRLHHENIVRYYNAWIE-------RHER 661
KLDG YA+K+I I A++ ++ EV +L+ L H NIV Y+ AWIE R +R
Sbjct: 187 KLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADR 246
Query: 662 PAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASA 721
A P + ++DR G ++ + A P E T + + S
Sbjct: 247 -AAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSV 305
Query: 722 RFPA--TGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNE 779
++ S + E E + G+ S +S E + +S E+ +E
Sbjct: 306 KYTTNLVIRESGELESTLELQENGLAGLS--ASSIVEQQLPLRRNSHLEESFTSTEESSE 363
Query: 780 KNGCHESEPSVTTEAVHY--LYIQMEYCEKSTL----------RDTIDQGL--YRDTVRL 825
+N + TEA ++ L+IQM+ CE S R+ +D+ Y
Sbjct: 364 ENVNFLGQ----TEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVA 419
Query: 826 WRLFREILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLA-TDHLAFSADSKQD 883
++F+E+++G+ YIH G++HRDLKP NIFL D VKIGDFGLA TD L K
Sbjct: 420 TKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL-----QKNT 474
Query: 884 DQTGDLIKSDPSGHLTGMVGTALYVSPE-VQGSTKSAYNQKVDLFSLGIIFFEMSYHPMV 942
D T K P+ T VGT LY SPE ++G S Y+ K D++SLG++ E+ + P
Sbjct: 475 DWTNRNGKRTPTH--TSRVGTCLYASPEQLEG---SEYDAKSDMYSLGVVLLEL-FQPFG 528
Query: 943 TASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSEL 1000
T ER VL LR + + PE Q I L + ++RP+A +LL+SEL
Sbjct: 529 TEMERAEVLTGLR---TGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582
Score = 33.1 bits (74), Expect = 2.3
Identities = 41/185 (22%), Positives = 78/185 (42%), Gaps = 39/185 (21%)
Query: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADICKEDV-------- 458
+L+ G+ Y+H+ +VH+ L N+ + + VKI D+ ++ DI +++
Sbjct: 425 ELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA--CTDILQKNTDWTNRNGK 482
Query: 459 ---FEQTRVRFSDNALPYKT-----GKKGDVWRLGLLLLSLSQ-------------GQEC 497
+RV A P + K D++ LG++LL L Q G
Sbjct: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRT 542
Query: 498 GEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF------INPQPKMPLVEQS 551
G+ P ++ P + +++ + +R S QLL+ +N +M ++EQ
Sbjct: 543 GQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 601
Query: 552 PEDSE 556
E +E
Sbjct: 602 KEIAE 606
>gi|6996014 histidyl-tRNA synthetase [Homo sapiens]
Length = 509
Score = 142 bits (359), Expect = 2e-33
Identities = 115/452 (25%), Positives = 213/452 (47%), Gaps = 31/452 (6%)
Query: 1055 NFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFM----DHSGM 1110
++S R +++ V + IIR FKRHGA + TP+ + + ++ E + + D G
Sbjct: 64 DYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGE 123
Query: 1111 LVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRK--LDRFHPKELLECAFDIVTSTT 1168
L+ L +DL +PFARY+A N + N+KRY I +V+R + R +E +C FDI
Sbjct: 124 LLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIA-GNF 182
Query: 1169 NSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVY--II 1226
+ +P AE + + EI+ +LQ ++ + +N +L + CG+ + K + +
Sbjct: 183 DPMIPDAECLKIMCEILS---SLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVD 239
Query: 1227 LYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQ-KTGIA 1285
D V+ + + E+ + L+ R+ +++Q G + + L++ K
Sbjct: 240 KLDKVSWEEVKNEMVGE---KGLAPEVADRIGDYVQQHGGVS----LVEQLLQDPKLSQN 292
Query: 1286 QLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEI 1345
+ GL DL+ + L GI ++ +L L + + G+I++ V Q +
Sbjct: 293 KQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPL 352
Query: 1346 ----LAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDKISAAVLN----MEESVTISSC 1397
+AAGGRYD L+ F G +G+SI +++I + V +EE + +
Sbjct: 353 GVGSVAAGGRYDGLVGMF---DPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTET 409
Query: 1398 DLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDK 1457
+LV S + + + L +LW AGI AE++Y + +YC I VA++ ++
Sbjct: 410 QVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQ 469
Query: 1458 EGSHVKVKSFEKERQTEKRVLETELVDHVLQK 1489
E +K + E V +LV+ + ++
Sbjct: 470 ELKDGVIKLRSVTSREEVDVRREDLVEEIKRR 501
>gi|15029520 histidyl-tRNA synthetase 2 precursor [Homo sapiens]
Length = 506
Score = 119 bits (299), Expect = 2e-26
Identities = 114/470 (24%), Positives = 204/470 (43%), Gaps = 50/470 (10%)
Query: 1053 KGNFSIRTAK-----------MQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEA 1101
K NF I+T K +++ + + +I FKRHGA + TP + ++ E
Sbjct: 52 KPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGED 111
Query: 1102 ALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRK--LDRFHPKE 1155
+ M D G L+ L +DL +PFARY+A N + +KRY + +V+R + + +E
Sbjct: 112 SGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYRE 171
Query: 1156 LLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGI 1215
+C FDI + +P AE + + EI+ LQ ++ I +N ++ + CG+
Sbjct: 172 FCQCDFDI-AGQFDPMIPDAECLKIMCEILS---GLQLGDFLIKVNDRRIVDGMFAVCGV 227
Query: 1216 PEDKLSQV--YIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPT 1273
PE K + I D + K R E+ K L+ R+ +++ G +
Sbjct: 228 PESKFRAICSSIDKLDKMAWKDVRHEMVVK---KGLAPEVADRIGDYVQCHGGV------ 278
Query: 1274 INSLIKQKTGIAQLVK-----YGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGII 1328
SL++Q +L + GL DL+ + L GI ++ +L L + + G+I
Sbjct: 279 --SLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVI 336
Query: 1329 FQFVAFIKRRQRAVPEI----LAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDKI--- 1381
++ V Q + +AAGGRYD L+ F G +G+SI +++I
Sbjct: 337 YEAVLLQTPTQAGEEPLNVGSVAAGGRYDGLVGMF---DPKGHKVPCVGLSIGVERIFYI 393
Query: 1382 -SAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ 1440
+ E V + + V + + + + L +LW +GI AE++Y +
Sbjct: 394 VEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQL 453
Query: 1441 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKL 1490
YC I V ++ ++E +K + E + V + ++L
Sbjct: 454 HYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRL 503
>gi|208431829 eukaryotic translation initiation factor 2-alpha kinase
2 isoform b [Homo sapiens]
Length = 510
Score = 115 bits (287), Expect = 5e-25
Identities = 88/254 (34%), Positives = 123/254 (48%), Gaps = 36/254 (14%)
Query: 761 FDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ--GL 818
FD + E S + D + +N + S L+IQME+C+K TL I++ G
Sbjct: 289 FDYDPETSDDSLESSDYDPENSKNSSRSKTKC-----LFIQMEFCDKGTLEQWIEKRRGE 343
Query: 819 YRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSA 878
D V LF +I G+ YIH K +IHRDLKP NIFL VKIGDFGL T
Sbjct: 344 KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS------ 397
Query: 879 DSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY 938
+K+D G T GT Y+SPE S Y ++VDL++LG+I E+
Sbjct: 398 -----------LKND--GKRTRSKGTLRYMSPEQISS--QDYGKEVDLYALGLILAEL-L 441
Query: 939 HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS 998
H TA E LRD + FD K+K+++ LL+ P RP +E+L++
Sbjct: 442 HVCDTAFETSKFFTDLRDGI---ISDIFD----KKEKTLLQKLLSKKPEDRPNTSEILRT 494
Query: 999 ELLPPPQMEESELH 1012
+ E++E H
Sbjct: 495 LTVWKKSPEKNERH 508
Score = 43.1 bits (100), Expect = 0.002
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT-RVRF 466
Q+ G+DY+HS ++H+ L SN+ + VKI D+ + L + K + T R
Sbjct: 356 QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMS 415
Query: 467 SDNALPYKTGKKGDVWRLGLLLLSL 491
+ GK+ D++ LGL+L L
Sbjct: 416 PEQISSQDYGKEVDLYALGLILAEL 440
>gi|208431827 eukaryotic translation initiation factor 2-alpha kinase
2 isoform a [Homo sapiens]
Length = 551
Score = 115 bits (287), Expect = 5e-25
Identities = 88/254 (34%), Positives = 123/254 (48%), Gaps = 36/254 (14%)
Query: 761 FDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ--GL 818
FD + E S + D + +N + S L+IQME+C+K TL I++ G
Sbjct: 330 FDYDPETSDDSLESSDYDPENSKNSSRSKTKC-----LFIQMEFCDKGTLEQWIEKRRGE 384
Query: 819 YRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSA 878
D V LF +I G+ YIH K +IHRDLKP NIFL VKIGDFGL T
Sbjct: 385 KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS------ 438
Query: 879 DSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY 938
+K+D G T GT Y+SPE S Y ++VDL++LG+I E+
Sbjct: 439 -----------LKND--GKRTRSKGTLRYMSPEQISS--QDYGKEVDLYALGLILAEL-L 482
Query: 939 HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS 998
H TA E LRD + FD K+K+++ LL+ P RP +E+L++
Sbjct: 483 HVCDTAFETSKFFTDLRDGI---ISDIFD----KKEKTLLQKLLSKKPEDRPNTSEILRT 535
Query: 999 ELLPPPQMEESELH 1012
+ E++E H
Sbjct: 536 LTVWKKSPEKNERH 549
Score = 57.8 bits (138), Expect = 9e-08
Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 585 RYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLH 644
R+ ++F+E++L+G G FG V K ++++DG Y +KR+ N + + EV L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKAEREVKALAKLD 316
Query: 645 HENIVRYYNAW 655
H NIV Y W
Sbjct: 317 HVNIVHYNGCW 327
Score = 43.1 bits (100), Expect = 0.002
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT-RVRF 466
Q+ G+DY+HS ++H+ L SN+ + VKI D+ + L + K + T R
Sbjct: 397 QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMS 456
Query: 467 SDNALPYKTGKKGDVWRLGLLLLSL 491
+ GK+ D++ LGL+L L
Sbjct: 457 PEQISSQDYGKEVDLYALGLILAEL 481
>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase 2
isoform a [Homo sapiens]
Length = 551
Score = 115 bits (287), Expect = 5e-25
Identities = 88/254 (34%), Positives = 123/254 (48%), Gaps = 36/254 (14%)
Query: 761 FDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ--GL 818
FD + E S + D + +N + S L+IQME+C+K TL I++ G
Sbjct: 330 FDYDPETSDDSLESSDYDPENSKNSSRSKTKC-----LFIQMEFCDKGTLEQWIEKRRGE 384
Query: 819 YRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSA 878
D V LF +I G+ YIH K +IHRDLKP NIFL VKIGDFGL T
Sbjct: 385 KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS------ 438
Query: 879 DSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY 938
+K+D G T GT Y+SPE S Y ++VDL++LG+I E+
Sbjct: 439 -----------LKND--GKRTRSKGTLRYMSPEQISS--QDYGKEVDLYALGLILAEL-L 482
Query: 939 HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS 998
H TA E LRD + FD K+K+++ LL+ P RP +E+L++
Sbjct: 483 HVCDTAFETSKFFTDLRDGI---ISDIFD----KKEKTLLQKLLSKKPEDRPNTSEILRT 535
Query: 999 ELLPPPQMEESELH 1012
+ E++E H
Sbjct: 536 LTVWKKSPEKNERH 549
Score = 57.8 bits (138), Expect = 9e-08
Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 585 RYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLH 644
R+ ++F+E++L+G G FG V K ++++DG Y +KR+ N + + EV L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKAEREVKALAKLD 316
Query: 645 HENIVRYYNAW 655
H NIV Y W
Sbjct: 317 HVNIVHYNGCW 327
Score = 43.1 bits (100), Expect = 0.002
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT-RVRF 466
Q+ G+DY+HS ++H+ L SN+ + VKI D+ + L + K + T R
Sbjct: 397 QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMS 456
Query: 467 SDNALPYKTGKKGDVWRLGLLLLSL 491
+ GK+ D++ LGL+L L
Sbjct: 457 PEQISSQDYGKEVDLYALGLILAEL 481
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 100 bits (250), Expect = 9e-21
Identities = 108/490 (22%), Positives = 199/490 (40%), Gaps = 78/490 (15%)
Query: 99 SNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQ 158
SN+ V K L+K + ++ +L + +S+H+K + E + +
Sbjct: 864 SNKYVQQEKQNTASLSKVNASRILTNDLEF---DSVSDHSKTLTNFSFQAKQESASSQTY 920
Query: 159 QRLLEAKRKEEQEQREILHEI------------QRRKEEIKEEKKRKEMAKQERLEIASL 206
Q + + + I +++ Q + + E+ E+ E+ +L
Sbjct: 921 QYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLAL 980
Query: 207 SNQDHTS------KKDPGGHRTAAILHGGSPDFVGNG----KHRANSSGRSRRERQYSVC 256
+D+ S + DP G +P +G K + +SSG +R+
Sbjct: 981 DEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFL 1040
Query: 257 NSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQ 316
S + E ++ S + ++ KG+ +G VY L T+ G + + + L
Sbjct: 1041 ISNEKKIFSEN---SLKSEEPILWTKGEILGKGAY--GTVYCGL-TSQGQLIAVKQVALD 1094
Query: 317 WQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVD 376
K+ +K+ + + E + L L H N+V YL L+E V
Sbjct: 1095 TSNKLA-------------AEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQEN----TVS 1137
Query: 377 ILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAE 436
I +E + G S+++ ++ GP+P +YT Q+L G+ YLH N VVH+ + +NV++
Sbjct: 1138 IFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPT 1197
Query: 437 GTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPY----------KTGKKGDVWRLGL 486
G +K+ D+ ++RLA + + S + PY G+K D+W +G
Sbjct: 1198 GIIKLIDFGCARRLAWAGLNGT--HSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGC 1255
Query: 487 LLLSLSQGQ-----------------ECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWS 529
+ ++ G+ G P +P + DF++ C+ D ER S
Sbjct: 1256 TVFEMATGKPPLASMDRMAAMFYIGAHRGLMP-PLPDHFSENAADFVRMCLTRDQHERPS 1314
Query: 530 PQQLLKHSFI 539
QLLKHSF+
Sbjct: 1315 ALQLLKHSFL 1324
Score = 68.9 bits (167), Expect = 4e-11
Identities = 51/175 (29%), Positives = 85/175 (48%), Gaps = 21/175 (12%)
Query: 830 REILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDL 889
++IL G+AY+HE ++HRD+K N+ L +K+ DFG A LA++
Sbjct: 1168 KQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAR-RLAWAG----------- 1215
Query: 890 IKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY-HPMVTASERI 948
+ S L M GT +++PEV +S Y +K D++S+G FEM+ P + + +R+
Sbjct: 1216 LNGTHSDMLKSMHGTPYWMAPEV--INESGYGRKSDIWSIGCTVFEMATGKPPLASMDRM 1273
Query: 949 FVLNQL--RDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELL 1001
+ + P P+ F + + L D +RP+A +LLK L
Sbjct: 1274 AAMFYIGAHRGLMPPLPDHFSE----NAADFVRMCLTRDQHERPSALQLLKHSFL 1324
Score = 38.9 bits (89), Expect = 0.042
Identities = 23/71 (32%), Positives = 39/71 (54%), Gaps = 6/71 (8%)
Query: 594 QLLGKGAFGAVIKVQNKLDGCCYAVKRIPINP-----ASRQFRRIKGEVTLLSRLHHENI 648
++LGKGA+G V G AVK++ ++ A +++R+++ EV LL L H NI
Sbjct: 1065 EILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNI 1123
Query: 649 VRYYNAWIERH 659
V Y ++ +
Sbjct: 1124 VAYLGTCLQEN 1134
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 99.0 bits (245), Expect = 3e-20
Identities = 74/272 (27%), Positives = 125/272 (45%), Gaps = 36/272 (13%)
Query: 335 KCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSL-AAHLSH 393
K +++++ E + L HPN+V+ L E + + IL+E +G ++ A L
Sbjct: 68 KSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENN----LWILIEFCAGGAVDAVMLEL 123
Query: 394 SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSIS-KRLAD 452
P+ Q++ Q L L+YLH N ++H+ L A N+L +G +K+ D+ +S K
Sbjct: 124 ERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRT 183
Query: 453 ICKEDVFEQTRVRFSDNALPYKTGK------KGDVWRLGLLLLSLSQGQE---------- 496
I + D F T + + +T K K DVW LG+ L+ +++ +
Sbjct: 184 IQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRV 243
Query: 497 ----CGEYPVTI--PSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPL--- 547
P T+ PS ++F+DFLKKC+ + RW+ QLL+H F+ P+
Sbjct: 244 LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIREL 303
Query: 548 -----VEQSPEDSEGQDYVETVIPSNRLPSAA 574
E + E +G++ E N LP A
Sbjct: 304 IAEAKAEVTEEVEDGKEEDEEEETENSLPIPA 335
Score = 60.8 bits (146), Expect = 1e-08
Identities = 55/207 (26%), Positives = 96/207 (46%), Gaps = 32/207 (15%)
Query: 743 GVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK----NGCHESEPSVTTEAVHY- 797
G F + + A + E+ ++ + ++KS+ + ED + C +A +Y
Sbjct: 43 GAFGKVY-KAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYE 101
Query: 798 --LYIQMEYCEKSTLRDTIDQGLYRDTV--RLWRLFREILDGLAYIHEKGMIHRDLKPVN 853
L+I +E+C + D + L R ++ + ++ LD L Y+H+ +IHRDLK N
Sbjct: 102 NNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGN 160
Query: 854 IFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEV- 912
I D +K+ DFG+ SA + + Q D +GT +++PEV
Sbjct: 161 ILFTLDGDIKLADFGV-------SAKNTRTIQRRD-----------SFIGTPYWMAPEVV 202
Query: 913 --QGSTKSAYNQKVDLFSLGIIFFEMS 937
+ S Y+ K D++SLGI EM+
Sbjct: 203 MCETSKDRPYDYKADVWSLGITLIEMA 229
Score = 34.3 bits (77), Expect = 1.0
Identities = 25/68 (36%), Positives = 31/68 (45%), Gaps = 8/68 (11%)
Query: 596 LGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVR----- 650
LG GAFG V K QNK A K I + + E+ +L+ H NIV+
Sbjct: 40 LGDGAFGKVYKAQNKETSVLAAAKVID-TKSEEELEDYMVEIDILASCDHPNIVKLLDAF 98
Query: 651 YY--NAWI 656
YY N WI
Sbjct: 99 YYENNLWI 106
Score = 33.9 bits (76), Expect = 1.3
Identities = 30/130 (23%), Positives = 66/130 (50%), Gaps = 15/130 (11%)
Query: 98 LSNESVNLLKSRLEELAKKHCGEVMIFE--LAYHVQSFLSEHNKPPPKSFHEEMLERRAQ 155
L E N L+ + + + E+ F+ L + ++E K P K +E+++RR +
Sbjct: 892 LEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAP-KELRKELMKRRKE 950
Query: 156 EEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKK 215
E L +++ +EQE +Q++++E+ + K++ +Q++ E+A++ + +K+
Sbjct: 951 E----LAQSQHAQEQEF------VQKQQQEL--DGSLKKIIQQQKAELANIERECLNNKQ 998
Query: 216 DPGGHRTAAI 225
R AAI
Sbjct: 999 QLMRAREAAI 1008
Score = 32.3 bits (72), Expect = 3.9
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 10/68 (14%)
Query: 147 EEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ-----RRKEEIKEEKK-----RKEMA 196
++ +ER QE RL + ++ + EQ + L + Q R+KE I E +K RKE+
Sbjct: 886 KQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELM 945
Query: 197 KQERLEIA 204
K+ + E+A
Sbjct: 946 KRRKEELA 953
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 95.9 bits (237), Expect = 3e-19
Identities = 65/230 (28%), Positives = 109/230 (47%), Gaps = 34/230 (14%)
Query: 337 KKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGP 396
+K+ + + E + L L H N+V YL L+E V I +E + G S+++ ++ GP
Sbjct: 284 EKEYRKLQEEVDLLKALKHVNIVAYLGTCLQEN----TVSIFMEFVPGGSISSIINRFGP 339
Query: 397 IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKE 456
+P +YT Q+L G+ YLH N VVH+ + +NV++ G +K+ D+ ++RLA
Sbjct: 340 LPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLN 399
Query: 457 DVFEQTRVRFSDNALPY----------KTGKKGDVWRLGLLLLSLSQGQ----------- 495
+ + S + PY G+K D+W +G + ++ G+
Sbjct: 400 GT--HSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAA 457
Query: 496 ------ECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI 539
G P +P + DF++ C+ D ER S QLLKHSF+
Sbjct: 458 MFYIGAHRGLMP-PLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 506
Score = 68.9 bits (167), Expect = 4e-11
Identities = 51/175 (29%), Positives = 85/175 (48%), Gaps = 21/175 (12%)
Query: 830 REILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDL 889
++IL G+AY+HE ++HRD+K N+ L +K+ DFG A LA++
Sbjct: 350 KQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAR-RLAWAG----------- 397
Query: 890 IKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY-HPMVTASERI 948
+ S L M GT +++PEV +S Y +K D++S+G FEM+ P + + +R+
Sbjct: 398 LNGTHSDMLKSMHGTPYWMAPEV--INESGYGRKSDIWSIGCTVFEMATGKPPLASMDRM 455
Query: 949 FVLNQL--RDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELL 1001
+ + P P+ F + + L D +RP+A +LLK L
Sbjct: 456 AAMFYIGAHRGLMPPLPDHFSE----NAADFVRMCLTRDQHERPSALQLLKHSFL 506
Score = 38.9 bits (89), Expect = 0.042
Identities = 23/71 (32%), Positives = 39/71 (54%), Gaps = 6/71 (8%)
Query: 594 QLLGKGAFGAVIKVQNKLDGCCYAVKRIPINP-----ASRQFRRIKGEVTLLSRLHHENI 648
++LGKGA+G V G AVK++ ++ A +++R+++ EV LL L H NI
Sbjct: 247 EILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNI 305
Query: 649 VRYYNAWIERH 659
V Y ++ +
Sbjct: 306 VAYLGTCLQEN 316
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 93.6 bits (231), Expect = 1e-18
Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 33/226 (14%)
Query: 338 KQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPI 397
K++ E E L L H +V+Y L+++ + + I +E++ G S+ L G +
Sbjct: 435 KEVSALECEIQLLKNLQHERIVQYYGC-LRDRAEKTLT-IFMEYMPGGSVKDQLKAYGAL 492
Query: 398 PVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKED 457
R+YT Q+L G+ YLHSN +VH+ + +N+L D+ G VK+ D+ SKRL IC
Sbjct: 493 TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--- 549
Query: 458 VFEQTRVRFSDNALPY----------KTGKKGDVWRLGLLLLS-LSQGQECGEYPV---- 502
T +R S PY G+K DVW LG ++ L++ EY
Sbjct: 550 -MSGTGMR-SVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAI 607
Query: 503 ----------TIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF 538
+PS + +DFL++ + ++ ++R S ++LL H F
Sbjct: 608 FKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHF 652
Score = 67.4 bits (163), Expect = 1e-10
Identities = 60/202 (29%), Positives = 94/202 (46%), Gaps = 26/202 (12%)
Query: 798 LYIQMEYCEKSTLRDTIDQ-GLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL 856
L I MEY +++D + G ++V + R+IL+G++Y+H ++HRD+K NI
Sbjct: 470 LTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILR 528
Query: 857 DSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGST 916
DS +VK+GDFG A+ L S TG + + GT ++SPEV +
Sbjct: 529 DSAGNVKLGDFG-ASKRLQTICMS----GTG----------MRSVTGTPYWMSPEV--IS 571
Query: 917 KSAYNQKVDLFSLGIIFFEM--SYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ 974
Y +K D++SLG EM P + PT+P+ P EH +
Sbjct: 572 GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHI--SEHGRD 629
Query: 975 KSVISWLLNHDPAKRPTATELL 996
+ + +RP+A ELL
Sbjct: 630 ---FLRRIFVEARQRPSAEELL 648
Score = 42.7 bits (99), Expect = 0.003
Identities = 26/78 (33%), Positives = 41/78 (52%), Gaps = 4/78 (5%)
Query: 588 IEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINP----ASRQFRRIKGEVTLLSRL 643
I + +LLG+GAFG V + G A K++ +P S++ ++ E+ LL L
Sbjct: 391 INWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL 450
Query: 644 HHENIVRYYNAWIERHER 661
HE IV+YY +R E+
Sbjct: 451 QHERIVQYYGCLRDRAEK 468
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 93.6 bits (231), Expect = 1e-18
Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 33/226 (14%)
Query: 338 KQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPI 397
K++ E E L L H +V+Y L+++ + + I +E++ G S+ L G +
Sbjct: 404 KEVSALECEIQLLKNLQHERIVQYYGC-LRDRAEKTLT-IFMEYMPGGSVKDQLKAYGAL 461
Query: 398 PVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKED 457
R+YT Q+L G+ YLHSN +VH+ + +N+L D+ G VK+ D+ SKRL IC
Sbjct: 462 TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--- 518
Query: 458 VFEQTRVRFSDNALPY----------KTGKKGDVWRLGLLLLS-LSQGQECGEYPV---- 502
T +R S PY G+K DVW LG ++ L++ EY
Sbjct: 519 -MSGTGMR-SVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAI 576
Query: 503 ----------TIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF 538
+PS + +DFL++ + ++ ++R S ++LL H F
Sbjct: 577 FKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHF 621
Score = 67.4 bits (163), Expect = 1e-10
Identities = 60/202 (29%), Positives = 94/202 (46%), Gaps = 26/202 (12%)
Query: 798 LYIQMEYCEKSTLRDTIDQ-GLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL 856
L I MEY +++D + G ++V + R+IL+G++Y+H ++HRD+K NI
Sbjct: 439 LTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILR 497
Query: 857 DSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGST 916
DS +VK+GDFG A+ L S TG + + GT ++SPEV +
Sbjct: 498 DSAGNVKLGDFG-ASKRLQTICMS----GTG----------MRSVTGTPYWMSPEV--IS 540
Query: 917 KSAYNQKVDLFSLGIIFFEM--SYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ 974
Y +K D++SLG EM P + PT+P+ P EH +
Sbjct: 541 GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHI--SEHGRD 598
Query: 975 KSVISWLLNHDPAKRPTATELL 996
+ + +RP+A ELL
Sbjct: 599 ---FLRRIFVEARQRPSAEELL 617
Score = 42.7 bits (99), Expect = 0.003
Identities = 26/78 (33%), Positives = 41/78 (52%), Gaps = 4/78 (5%)
Query: 588 IEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINP----ASRQFRRIKGEVTLLSRL 643
I + +LLG+GAFG V + G A K++ +P S++ ++ E+ LL L
Sbjct: 360 INWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL 419
Query: 644 HHENIVRYYNAWIERHER 661
HE IV+YY +R E+
Sbjct: 420 QHERIVQYYGCLRDRAEK 437
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 92.8 bits (229), Expect = 2e-18
Identities = 71/275 (25%), Positives = 120/275 (43%), Gaps = 37/275 (13%)
Query: 333 IDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS 392
+++ + +I+ + E L + V +Y LK + I++E++ G S A L
Sbjct: 57 LEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSK----LWIIMEYLGGGS-ALDLL 111
Query: 393 HSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLAD 452
+GP Q+ ++L GLDYLHS +H+ + A+NVL+ +G VK+ D+ ++ +L D
Sbjct: 112 RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 171
Query: 453 I-CKEDVFEQTRVRFSDNALPYKT-GKKGDVWRLGLLLLSLSQGQECG------------ 498
K + F T + + K D+W LG+ + L++G+
Sbjct: 172 TQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI 231
Query: 499 --EYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI--NPQPKMPLVE----- 549
P T+ D F++F+ C+ D R + ++LLKH FI N + L E
Sbjct: 232 PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRF 291
Query: 550 ---------QSPEDSEGQDYVETVIPSNRLPSAAF 575
DSEG D T +N P +F
Sbjct: 292 KRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSF 326
Score = 88.6 bits (218), Expect = 5e-17
Identities = 73/226 (32%), Positives = 105/226 (46%), Gaps = 40/226 (17%)
Query: 798 LYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLD 857
L+I MEY + D + G + D ++ + +EIL GL Y+H + IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPF-DEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 858 SDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTK 917
VK+ DFG+A G L +D VGT +++PEV +
Sbjct: 154 EQGDVKLADFGVA----------------GQL--TDTQIKRNTFVGTPFWMAPEV--IQQ 193
Query: 918 SAYNQKVDLFSLGIIFFEMS--------YHPMVTASERIFVLNQLRDPTSPKFPEDFDDG 969
SAY+ K D++SLGI E++ HPM R+ L +P P DF
Sbjct: 194 SAYDSKADIWSLGITAIELAKGEPPNSDMHPM-----RVLFLIPKNNP--PTLVGDFT-- 244
Query: 970 EHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVL 1015
K I LN DP+ RPTA ELLK + + + S L E++
Sbjct: 245 --KSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 288
Score = 41.6 bits (96), Expect = 0.006
Identities = 20/68 (29%), Positives = 38/68 (55%)
Query: 590 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV 649
F +L+ +GKG+FG V K + A+K I + A + I+ E+T+LS+ +
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 650 RYYNAWIE 657
+YY ++++
Sbjct: 84 KYYGSYLK 91
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 92.0 bits (227), Expect = 4e-18
Identities = 76/249 (30%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 353 LSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHL-SHSGPIPVHQLRRYTAQLLS 411
L H N+V+YL ++ + I +E + G SL+A L S GP+ ++ YT Q+L
Sbjct: 179 LKHRNIVQYLG----SVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILE 234
Query: 412 GLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADI--CKEDVFEQTRVRFSD 468
GL YLH N +VH+ + NVLV+ G VKI+D+ SKRLA + C E F T +
Sbjct: 235 GLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTE-TFTGTLQYMAP 293
Query: 469 NAL---PYKTGKKGDVWRLGLLLLSLSQGQ----ECGEYPVT------------IPSDLP 509
+ P G D+W LG ++ ++ + E GE IP L
Sbjct: 294 EIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALS 353
Query: 510 ADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSEGQDYVETVIPSNR 569
A+ + F+ C D +R + +LL+ F+ K + + SEG V +P+
Sbjct: 354 AEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQG 413
Query: 570 LPSAAFFSE 578
P A SE
Sbjct: 414 EPMATSSSE 422
Score = 60.8 bits (146), Expect = 1e-08
Identities = 46/178 (25%), Positives = 77/178 (43%), Gaps = 30/178 (16%)
Query: 830 REILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLATDHLAFSADSKQDDQTGD 888
++IL+GL Y+HE ++HRD+K N+ +++ VKI DFG + + ++
Sbjct: 230 KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTET------ 283
Query: 889 LIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMS-----YHPMVT 943
GT Y++PE+ Y D++SLG EM+ +H +
Sbjct: 284 ------------FTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGE 331
Query: 944 ASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELL 1001
+F + + P+ PE A+ ++ I DP KR T ELL+ L
Sbjct: 332 PQAAMFKVGMFK--IHPEIPEALS----AEARAFILSCFEPDPHKRATTAELLREGFL 383
Score = 32.7 bits (73), Expect = 3.0
Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 592 ELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRY 651
E +LGKG +G V ++ + A+K IP SR + + E+ L L H NIV+Y
Sbjct: 129 ERVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKYLKHRNIVQY 187
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 90.5 bits (223), Expect = 1e-17
Identities = 66/214 (30%), Positives = 105/214 (49%), Gaps = 34/214 (15%)
Query: 798 LYIQMEYCEKSTLRDTIDQGL----YRDTVRLWRLFREILDGLAYIHEKG-----MIHRD 848
LYI MEYCE L I +G Y D + R+ ++ L H + ++HRD
Sbjct: 82 LYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRD 141
Query: 849 LKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYV 908
LKP N+FLD +VK+GDFGLA ++ D S T VGT Y+
Sbjct: 142 LKPANVFLDGKQNVKLGDFGLAR-----------------ILNHDTSFAKT-FVGTPYYM 183
Query: 909 SPEVQGSTKSAYNQKVDLFSLGIIFFEM-SYHPMVTASERIFVLNQLRDPTSPKFPEDFD 967
SPE + +YN+K D++SLG + +E+ + P TA + + ++R+ + P +
Sbjct: 184 SPEQM--NRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYS 241
Query: 968 DGEHAKQKSVISWLLNHDPAKRPTATELLKSELL 1001
D + +I+ +LN RP+ E+L++ L+
Sbjct: 242 D----ELNEIITRMLNLKDYHRPSVEEILENPLI 271
Score = 53.1 bits (126), Expect = 2e-06
Identities = 61/249 (24%), Positives = 106/249 (42%), Gaps = 31/249 (12%)
Query: 318 QKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDI 377
+K G L +E + + + Q +E N L +L HPN+VRY + + ++ I
Sbjct: 27 RKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLY--I 84
Query: 378 LVEHISGVSLAAHLSHSGP----IPVHQLRRYTAQLLSGLDYLHSNS-----VVHKVLSA 428
++E+ G LA+ ++ + + R QL L H S V+H+ L
Sbjct: 85 VMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKP 144
Query: 429 SNVLVDAEGTVKITDYSISKRL-ADICKEDVFEQTRVRFSD---NALPYKTGKKGDVWRL 484
+NV +D + VK+ D+ +++ L D F T S N + Y +K D+W L
Sbjct: 145 ANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSY--NEKSDIWSL 202
Query: 485 GLLLLSL----------SQGQECGEYPV----TIPSDLPADFQDFLKKCVCLDDKERWSP 530
G LL L SQ + G+ IP + + + + + L D R S
Sbjct: 203 GCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSV 262
Query: 531 QQLLKHSFI 539
+++L++ I
Sbjct: 263 EEILENPLI 271
Score = 43.9 bits (102), Expect = 0.001
Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRR-IKGEVTLLSRLHHEN 647
++E L +G G++G K++ K DG K + + ++ + EV LL L H N
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
Query: 648 IVRYYNAWIER 658
IVRYY+ I+R
Sbjct: 67 IVRYYDRIIDR 77
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 90.1 bits (222), Expect = 2e-17
Identities = 80/270 (29%), Positives = 123/270 (45%), Gaps = 49/270 (18%)
Query: 760 IFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYL-----YIQMEYCEKSTLRDTI 814
I D E+ + ++ ++ + C P +T YL +I MEY + D +
Sbjct: 50 IIDLEEAEDEIEDIQQEITVLSQC--DSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL 107
Query: 815 DQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 874
G +T + + REIL GL Y+H + IHRD+K N+ L VK+ DFG+A
Sbjct: 108 KPGPLEETY-IATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA---- 162
Query: 875 AFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFF 934
G L +D VGT +++PEV +SAY+ K D++SLGI
Sbjct: 163 ------------GQL--TDTQIKRNTFVGTPFWMAPEV--IKQSAYDFKADIWSLGITAI 206
Query: 935 EMS--------YHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ-KSVISWLLNHD 985
E++ HPM +F++ + PT +G+H+K K + LN D
Sbjct: 207 ELAKGEPPNSDLHPM----RVLFLIPKNSPPTL--------EGQHSKPFKEFVEACLNKD 254
Query: 986 PAKRPTATELLKSELLPPPQMEESELHEVL 1015
P RPTA ELLK + + + S L E++
Sbjct: 255 PRFRPTAKELLKHKFITRYTKKTSFLTELI 284
Score = 89.7 bits (221), Expect = 2e-17
Identities = 60/228 (26%), Positives = 108/228 (47%), Gaps = 21/228 (9%)
Query: 333 IDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS 392
+++ + +I+ + E L + P + RY LK S + I++E++ G S A L
Sbjct: 53 LEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLK----STKLWIIMEYLGGGS-ALDLL 107
Query: 393 HSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLAD 452
GP+ + ++L GLDYLHS +H+ + A+NVL+ +G VK+ D+ ++ +L D
Sbjct: 108 KPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
Query: 453 I-CKEDVFEQTRVRFSDNALPYKT-GKKGDVWRLGLLLLSLSQGQECG------------ 498
K + F T + + K D+W LG+ + L++G+
Sbjct: 168 TQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI 227
Query: 499 --EYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPK 544
P T+ F++F++ C+ D + R + ++LLKH FI K
Sbjct: 228 PKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTK 275
Score = 39.3 bits (90), Expect = 0.032
Identities = 21/68 (30%), Positives = 37/68 (54%)
Query: 590 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV 649
F +L +GKG+FG V K + A+K I + A + I+ E+T+LS+ I
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 650 RYYNAWIE 657
RY+ ++++
Sbjct: 80 RYFGSYLK 87
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 89.7 bits (221), Expect = 2e-17
Identities = 77/266 (28%), Positives = 125/266 (46%), Gaps = 41/266 (15%)
Query: 760 IFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYL-----YIQMEYCEKSTLRDTI 814
I D E+ + ++ ++ + C P VT YL +I MEY + D +
Sbjct: 54 IIDLEEAEDEIEDIQQEITVLSQC--DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL 111
Query: 815 DQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 874
+ G +T ++ + REIL GL Y+H + IHRD+K N+ L VK+ DFG+A
Sbjct: 112 EPGPLDET-QIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA---- 166
Query: 875 AFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFF 934
G L +D VGT +++PEV +SAY+ K D++SLGI
Sbjct: 167 ------------GQL--TDTQIKRNTFVGTPFWMAPEV--IKQSAYDSKADIWSLGITAI 210
Query: 935 EMSY----HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ-KSVISWLLNHDPAKR 989
E++ H + + +F++ + PT +G ++K K + LN +P+ R
Sbjct: 211 ELARGEPPHSELHPMKVLFLIPKNNPPTL--------EGNYSKPLKEFVEACLNKEPSFR 262
Query: 990 PTATELLKSELLPPPQMEESELHEVL 1015
PTA ELLK + + + S L E++
Sbjct: 263 PTAKELLKHKFILRNAKKTSYLTELI 288
Score = 88.2 bits (217), Expect = 6e-17
Identities = 64/256 (25%), Positives = 115/256 (44%), Gaps = 34/256 (13%)
Query: 333 IDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS 392
+++ + +I+ + E L + P V +Y LK+ + I++E++ G S A L
Sbjct: 57 LEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTK----LWIIMEYLGGGS-ALDLL 111
Query: 393 HSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLAD 452
GP+ Q+ ++L GLDYLHS +H+ + A+NVL+ G VK+ D+ ++ +L D
Sbjct: 112 EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTD 171
Query: 453 I-CKEDVFEQTRVRFSDNALPYKT-GKKGDVWRLGLLLLSLSQGQE-------------- 496
K + F T + + K D+W LG+ + L++G+
Sbjct: 172 TQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI 231
Query: 497 CGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMP---------- 546
P T+ + ++F++ C+ + R + ++LLKH FI K
Sbjct: 232 PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRY 291
Query: 547 ---LVEQSPEDSEGQD 559
EQS +DS +D
Sbjct: 292 KRWKAEQSHDDSSSED 307
Score = 41.2 bits (95), Expect = 0.008
Identities = 20/68 (29%), Positives = 38/68 (55%)
Query: 590 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV 649
F +L+ +GKG+FG V K + A+K I + A + I+ E+T+LS+ +
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 650 RYYNAWIE 657
+YY ++++
Sbjct: 84 KYYGSYLK 91
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 89.7 bits (221), Expect = 2e-17
Identities = 77/266 (28%), Positives = 125/266 (46%), Gaps = 41/266 (15%)
Query: 760 IFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYL-----YIQMEYCEKSTLRDTI 814
I D E+ + ++ ++ + C P VT YL +I MEY + D +
Sbjct: 66 IIDLEEAEDEIEDIQQEITVLSQC--DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL 123
Query: 815 DQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 874
+ G +T ++ + REIL GL Y+H + IHRD+K N+ L VK+ DFG+A
Sbjct: 124 EPGPLDET-QIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA---- 178
Query: 875 AFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFF 934
G L +D VGT +++PEV +SAY+ K D++SLGI
Sbjct: 179 ------------GQL--TDTQIKRNTFVGTPFWMAPEV--IKQSAYDSKADIWSLGITAI 222
Query: 935 EMSY----HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ-KSVISWLLNHDPAKR 989
E++ H + + +F++ + PT +G ++K K + LN +P+ R
Sbjct: 223 ELARGEPPHSELHPMKVLFLIPKNNPPTL--------EGNYSKPLKEFVEACLNKEPSFR 274
Query: 990 PTATELLKSELLPPPQMEESELHEVL 1015
PTA ELLK + + + S L E++
Sbjct: 275 PTAKELLKHKFILRNAKKTSYLTELI 300
Score = 88.2 bits (217), Expect = 6e-17
Identities = 64/256 (25%), Positives = 115/256 (44%), Gaps = 34/256 (13%)
Query: 333 IDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS 392
+++ + +I+ + E L + P V +Y LK+ + I++E++ G S A L
Sbjct: 69 LEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTK----LWIIMEYLGGGS-ALDLL 123
Query: 393 HSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLAD 452
GP+ Q+ ++L GLDYLHS +H+ + A+NVL+ G VK+ D+ ++ +L D
Sbjct: 124 EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTD 183
Query: 453 I-CKEDVFEQTRVRFSDNALPYKT-GKKGDVWRLGLLLLSLSQGQE-------------- 496
K + F T + + K D+W LG+ + L++G+
Sbjct: 184 TQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI 243
Query: 497 CGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMP---------- 546
P T+ + ++F++ C+ + R + ++LLKH FI K
Sbjct: 244 PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRY 303
Query: 547 ---LVEQSPEDSEGQD 559
EQS +DS +D
Sbjct: 304 KRWKAEQSHDDSSSED 319
Score = 41.2 bits (95), Expect = 0.008
Identities = 20/68 (29%), Positives = 38/68 (55%)
Query: 590 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV 649
F +L+ +GKG+FG V K + A+K I + A + I+ E+T+LS+ +
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 650 RYYNAWIE 657
+YY ++++
Sbjct: 96 KYYGSYLK 103
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 89.0 bits (219), Expect = 4e-17
Identities = 64/231 (27%), Positives = 103/231 (44%), Gaps = 33/231 (14%)
Query: 377 ILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAE 436
I++E++ G S A L +GP Q+ ++L GLDYLHS +H+ + A+NVL+ +
Sbjct: 20 IIMEYLGGGS-ALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQ 78
Query: 437 GTVKITDYSISKRLADI-CKEDVFEQTRVRFSDNALPYKT-GKKGDVWRLGLLLLSLSQG 494
G VK+ D+ ++ +L D K + F T + + K D+W LG+ + L++G
Sbjct: 79 GDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKG 138
Query: 495 QECG--------------EYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI- 539
+ P T+ D F++F+ C+ D R + ++LLKH FI
Sbjct: 139 EPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIV 198
Query: 540 -NPQPKMPLVE--------------QSPEDSEGQDYVETVIPSNRLPSAAF 575
N + L E DSEG D T +N P +F
Sbjct: 199 KNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSF 249
Score = 88.6 bits (218), Expect = 5e-17
Identities = 73/226 (32%), Positives = 105/226 (46%), Gaps = 40/226 (17%)
Query: 798 LYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLD 857
L+I MEY + D + G + D ++ + +EIL GL Y+H + IHRD+K N+ L
Sbjct: 18 LWIIMEYLGGGSALDLLRAGPF-DEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 76
Query: 858 SDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTK 917
VK+ DFG+A G L +D VGT +++PEV +
Sbjct: 77 EQGDVKLADFGVA----------------GQL--TDTQIKRNTFVGTPFWMAPEV--IQQ 116
Query: 918 SAYNQKVDLFSLGIIFFEMS--------YHPMVTASERIFVLNQLRDPTSPKFPEDFDDG 969
SAY+ K D++SLGI E++ HPM R+ L +P P DF
Sbjct: 117 SAYDSKADIWSLGITAIELAKGEPPNSDMHPM-----RVLFLIPKNNP--PTLVGDFT-- 167
Query: 970 EHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVL 1015
K I LN DP+ RPTA ELLK + + + S L E++
Sbjct: 168 --KSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 211
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 89.0 bits (219), Expect = 4e-17
Identities = 63/202 (31%), Positives = 96/202 (47%), Gaps = 23/202 (11%)
Query: 798 LYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLD 857
+YI MEYC++ TL + GL +RL+ ++I + +HE G++HRD+K NIFL
Sbjct: 1415 MYIFMEYCDEGTLEEVSRLGLQEHVIRLYS--KQITIAINVLHEHGIVHRDIKGANIFLT 1472
Query: 858 SDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTK 917
S +K+GDFG S K + QT G + +GTA Y++PEV K
Sbjct: 1473 SSGLIKLGDFGC-------SVKLKNNAQT-------MPGEVNSTLGTAAYMAPEVITRAK 1518
Query: 918 -SAYNQKVDLFSLGIIFFEM--SYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ 974
+ + D++SLG + EM P ++ ++ P PE +
Sbjct: 1519 GEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLS----PEG 1574
Query: 975 KSVISWLLNHDPAKRPTATELL 996
K +S L DP R TA++LL
Sbjct: 1575 KDFLSHCLESDPKMRWTASQLL 1596
Score = 79.0 bits (193), Expect = 4e-14
Identities = 56/231 (24%), Positives = 99/231 (42%), Gaps = 40/231 (17%)
Query: 338 KQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDIL----VEHISGVSLAAHLSH 393
K I+ T E + HPN+VRY + L ++ I ++ +E +S + L H+
Sbjct: 1382 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHV-- 1439
Query: 394 SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADI 453
+R Y+ Q+ ++ LH + +VH+ + +N+ + + G +K+ D+ S +L +
Sbjct: 1440 --------IRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN 1491
Query: 454 CKEDVFEQTRV---------RFSDNALPYKTGKKGDVWRLGLLLLSLSQGQE-------- 496
+ E A G+ D+W LG +++ + G+
Sbjct: 1492 AQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN 1551
Query: 497 --------CGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI 539
G P IP L + +DFL C+ D K RW+ QLL HSF+
Sbjct: 1552 FQIMYKVGMGHKP-PIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1601
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 89.0 bits (219), Expect = 4e-17
Identities = 63/202 (31%), Positives = 96/202 (47%), Gaps = 23/202 (11%)
Query: 798 LYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLD 857
+YI MEYC++ TL + GL +RL+ ++I + +HE G++HRD+K NIFL
Sbjct: 1365 MYIFMEYCDEGTLEEVSRLGLQEHVIRLYS--KQITIAINVLHEHGIVHRDIKGANIFLT 1422
Query: 858 SDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTK 917
S +K+GDFG S K + QT G + +GTA Y++PEV K
Sbjct: 1423 SSGLIKLGDFGC-------SVKLKNNAQT-------MPGEVNSTLGTAAYMAPEVITRAK 1468
Query: 918 -SAYNQKVDLFSLGIIFFEM--SYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ 974
+ + D++SLG + EM P ++ ++ P PE +
Sbjct: 1469 GEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLS----PEG 1524
Query: 975 KSVISWLLNHDPAKRPTATELL 996
K +S L DP R TA++LL
Sbjct: 1525 KDFLSHCLESDPKMRWTASQLL 1546
Score = 79.0 bits (193), Expect = 4e-14
Identities = 56/231 (24%), Positives = 99/231 (42%), Gaps = 40/231 (17%)
Query: 338 KQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDIL----VEHISGVSLAAHLSH 393
K I+ T E + HPN+VRY + L ++ I ++ +E +S + L H+
Sbjct: 1332 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHV-- 1389
Query: 394 SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADI 453
+R Y+ Q+ ++ LH + +VH+ + +N+ + + G +K+ D+ S +L +
Sbjct: 1390 --------IRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN 1441
Query: 454 CKEDVFEQTRV---------RFSDNALPYKTGKKGDVWRLGLLLLSLSQGQE-------- 496
+ E A G+ D+W LG +++ + G+
Sbjct: 1442 AQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN 1501
Query: 497 --------CGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI 539
G P IP L + +DFL C+ D K RW+ QLL HSF+
Sbjct: 1502 FQIMYKVGMGHKP-PIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1551
>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
[Homo sapiens]
Length = 545
Score = 88.6 bits (218), Expect = 5e-17
Identities = 66/204 (32%), Positives = 100/204 (49%), Gaps = 34/204 (16%)
Query: 828 LFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTG 887
+ +E+L+GL Y+H G IHRDLK NI L D V+I DFG++ AF A D T
Sbjct: 172 ILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVS----AFLATG--GDVTR 225
Query: 888 DLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMS--------YH 939
+ ++ VGT +++PEV + Y+ K D++S GI E++ Y
Sbjct: 226 NKVRKT-------FVGTPCWMAPEVMEQVR-GYDFKADMWSFGITAIELATGAAPYHKYP 277
Query: 940 PMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ-----KSVISWLLNHDPAKRPTATE 994
PM ++ +L DP P +D E K+ + ++S L DP+KRPTA E
Sbjct: 278 PM-----KVLMLTLQNDP--PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 330
Query: 995 LLKSELLPPPQMEESELHEVLHHT 1018
LLK + + E + ++L T
Sbjct: 331 LLKCKFFQKAKNREYLIEKLLTRT 354
Score = 68.9 bits (167), Expect = 4e-11
Identities = 61/245 (24%), Positives = 108/245 (44%), Gaps = 43/245 (17%)
Query: 333 IDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS 392
++KC+ + E ++ + SHPNVV Y + + + +V+ +L SG S+ +
Sbjct: 96 LEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLL----SGGSMLDIIK 151
Query: 393 H--------SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDY 444
+ +G + + ++L GLDYLH N +H+ L A N+L+ +G+V+I D+
Sbjct: 152 YIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADF 211
Query: 445 SISKRLA---DICKEDV---FEQTRVRFSDNALPYKTGK--KGDVWRLGLLLLSLSQG-Q 495
+S LA D+ + V F T + + G K D+W G+ + L+ G
Sbjct: 212 GVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAA 271
Query: 496 ECGEYP------VTIPSDLPA----------------DFQDFLKKCVCLDDKERWSPQQL 533
+YP +T+ +D P F+ L C+ D +R + +L
Sbjct: 272 PYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 331
Query: 534 LKHSF 538
LK F
Sbjct: 332 LKCKF 336
Score = 33.5 bits (75), Expect = 1.8
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 590 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV 649
+E +++G GA V K A+KRI + + E+ +S+ H N+V
Sbjct: 63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 122
Query: 650 RYYNAWIERHE 660
YY +++ + E
Sbjct: 123 TYYTSFVVKDE 133
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 88.6 bits (218), Expect = 5e-17
Identities = 75/234 (32%), Positives = 110/234 (47%), Gaps = 35/234 (14%)
Query: 352 KLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHL-SHSGPIPVHQ--LRRYTAQ 408
+L H N+VRYL + I +E + G SL++ L S GP+ ++ + YT Q
Sbjct: 699 RLRHKNIVRYLG----SASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQ 754
Query: 409 LLSGLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADI--CKEDVFEQTRVR 465
+L GL YLH N +VH+ + NVL++ G +KI+D+ SKRLA I C E F T
Sbjct: 755 ILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTE-TFTGTLQY 813
Query: 466 FSDNAL---PYKTGKKGDVWRLGLLLLSLSQGQ--------------ECGEYPV--TIPS 506
+ + P GK D+W LG ++ ++ G+ + G Y V +PS
Sbjct: 814 MAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPS 873
Query: 507 DLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINP-----QPKMPLVEQSPEDS 555
L A+ Q FL + D + R S Q LL F+ P P P P D+
Sbjct: 874 SLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDA 927
Score = 55.1 bits (131), Expect = 6e-07
Identities = 43/186 (23%), Positives = 77/186 (41%), Gaps = 30/186 (16%)
Query: 830 REILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLATDHLAFSADSKQDDQTGD 888
R+IL GL Y+H+ ++HRD+K N+ +++ +KI DFG + + ++
Sbjct: 753 RQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTET------ 806
Query: 889 LIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMS-----YHPMVT 943
GT Y++PE+ Y + D++SLG EM+ +H + +
Sbjct: 807 ------------FTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGS 854
Query: 944 ASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPP 1003
+F + + P P A+ ++ + DP R +A LL L P
Sbjct: 855 PQAAMFQVGMYK--VHPPMPSSLS----AEAQAFLLRTFEPDPRLRASAQTLLGDPFLQP 908
Query: 1004 PQMEES 1009
+ S
Sbjct: 909 GKRSRS 914
Score = 40.0 bits (92), Expect = 0.019
Identities = 25/70 (35%), Positives = 37/70 (52%), Gaps = 1/70 (1%)
Query: 582 QFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLS 641
+F + E E +LGKG +G V +++ A+K IP SR + + E+ L
Sbjct: 640 EFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQPLHEEIALHR 698
Query: 642 RLHHENIVRY 651
RL H+NIVRY
Sbjct: 699 RLRHKNIVRY 708
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 87.4 bits (215), Expect = 1e-16
Identities = 62/228 (27%), Positives = 106/228 (46%), Gaps = 33/228 (14%)
Query: 338 KQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPI 397
K++ E E L L H +V+Y Q+ ++ I +E++ G S+ L G +
Sbjct: 398 KEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTL--SIFMEYMPGGSIKDQLKAYGAL 455
Query: 398 PVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKED 457
+ R+YT Q+L G+ YLHSN +VH+ + +N+L D+ G VK+ D+ SKRL IC
Sbjct: 456 TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSG 515
Query: 458 VFEQTRVRFSDNALPY----------KTGKKGDVWRLGLLLLS-LSQGQECGEYPV---- 502
+ S PY G+K D+W + ++ L++ E+
Sbjct: 516 TGMK-----SVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAI 570
Query: 503 ----------TIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN 540
+P + +DFLK+ + ++ K R S +LL+H F++
Sbjct: 571 FKIATQPTNPKLPPHVSDYTRDFLKR-IFVEAKLRPSADELLRHMFVH 617
Score = 66.2 bits (160), Expect = 2e-10
Identities = 60/204 (29%), Positives = 91/204 (44%), Gaps = 28/204 (13%)
Query: 798 LYIQMEYCEKSTLRDTIDQ--GLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIF 855
L I MEY +++D + L + R + R+IL+G+ Y+H ++HRD+K NI
Sbjct: 433 LSIFMEYMPGGSIKDQLKAYGALTENVTRKYT--RQILEGVHYLHSNMIVHRDIKGANIL 490
Query: 856 LDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGS 915
DS +VK+GDFG A+ L S G +KS + GT ++SPEV
Sbjct: 491 RDSTGNVKLGDFG-ASKRLQTICLS------GTGMKS--------VTGTPYWMSPEV--I 533
Query: 916 TKSAYNQKVDLFSLGIIFFEM--SYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAK 973
+ Y +K D++S+ EM P + PT+PK P D
Sbjct: 534 SGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF 593
Query: 974 QKSVISWLLNHDPAKRPTATELLK 997
K + + RP+A ELL+
Sbjct: 594 LKRIFV-----EAKLRPSADELLR 612
Score = 42.0 bits (97), Expect = 0.005
Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 4/72 (5%)
Query: 594 QLLGKGAFGAVIKVQNKLDGCCYAVKRIPINP----ASRQFRRIKGEVTLLSRLHHENIV 649
+LLG+GAFG V + G AVK++ +P S++ ++ E+ LL L HE IV
Sbjct: 360 KLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIV 419
Query: 650 RYYNAWIERHER 661
+YY + E+
Sbjct: 420 QYYGCLRDPQEK 431
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 87.4 bits (215), Expect = 1e-16
Identities = 66/210 (31%), Positives = 100/210 (47%), Gaps = 33/210 (15%)
Query: 793 EAVHYLYIQMEYCEKSTLRDTIDQGLYR----DTVRLWRLFREILDGLAYIHEKGMIHRD 848
EA +LYI MEYC+ L I Q + D + W F ++ G+ +IH+K ++HRD
Sbjct: 70 EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNW--FTQMCLGVNHIHKKRVLHRD 127
Query: 849 LKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYV 908
+K NIFL + VK+GDFG A + S+P VGT YV
Sbjct: 128 IKSKNIFLTQNGKVKLGDFGSAR------------------LLSNPMAFACTYVGTPYYV 169
Query: 909 SPEVQGSTKSAYNQKVDLFSLGIIFFEMS--YHPMVTASERIFVLNQLRDPTSPKFPEDF 966
PE+ + YN K D++SLG I +E+ HP S + +L + SP P +
Sbjct: 170 PPEIWENL--PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISP-LPSHY 226
Query: 967 DDGEHAKQKSVISWLLNHDPAKRPTATELL 996
+ + ++ + +P+ RP+AT LL
Sbjct: 227 S----YELQFLVKQMFKRNPSHRPSATTLL 252
Score = 47.8 bits (112), Expect = 9e-05
Identities = 40/170 (23%), Positives = 73/170 (42%), Gaps = 20/170 (11%)
Query: 332 KIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHL 391
++ K Q + E L K+ HPN+V + E + I++E+ G L +
Sbjct: 36 RLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGH----LYIVMEYCDGGDLMQKI 91
Query: 392 SHSGP--IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKR 449
P + + Q+ G++++H V+H+ + + N+ + G VK+ D+ ++
Sbjct: 92 KQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARL 151
Query: 450 LADICKEDVFEQTRV--------RFSDNALPYKTGKKGDVWRLGLLLLSL 491
L++ F T V +N LPY K D+W LG +L L
Sbjct: 152 LSN---PMAFACTYVGTPYYVPPEIWEN-LPY--NNKSDIWSLGCILYEL 195
Score = 38.9 bits (89), Expect = 0.042
Identities = 17/63 (26%), Positives = 37/63 (58%)
Query: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENI 648
++ L+++G+G+FG + VQ++ +A+K I + + + + E LL+++ H NI
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNI 62
Query: 649 VRY 651
V +
Sbjct: 63 VAF 65
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 87.4 bits (215), Expect = 1e-16
Identities = 66/210 (31%), Positives = 100/210 (47%), Gaps = 33/210 (15%)
Query: 793 EAVHYLYIQMEYCEKSTLRDTIDQGLYR----DTVRLWRLFREILDGLAYIHEKGMIHRD 848
EA +LYI MEYC+ L I Q + D + W F ++ G+ +IH+K ++HRD
Sbjct: 70 EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNW--FTQMCLGVNHIHKKRVLHRD 127
Query: 849 LKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYV 908
+K NIFL + VK+GDFG A + S+P VGT YV
Sbjct: 128 IKSKNIFLTQNGKVKLGDFGSAR------------------LLSNPMAFACTYVGTPYYV 169
Query: 909 SPEVQGSTKSAYNQKVDLFSLGIIFFEMS--YHPMVTASERIFVLNQLRDPTSPKFPEDF 966
PE+ + YN K D++SLG I +E+ HP S + +L + SP P +
Sbjct: 170 PPEIWENL--PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISP-LPSHY 226
Query: 967 DDGEHAKQKSVISWLLNHDPAKRPTATELL 996
+ + ++ + +P+ RP+AT LL
Sbjct: 227 S----YELQFLVKQMFKRNPSHRPSATTLL 252
Score = 47.8 bits (112), Expect = 9e-05
Identities = 40/170 (23%), Positives = 73/170 (42%), Gaps = 20/170 (11%)
Query: 332 KIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHL 391
++ K Q + E L K+ HPN+V + E + I++E+ G L +
Sbjct: 36 RLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGH----LYIVMEYCDGGDLMQKI 91
Query: 392 SHSGP--IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKR 449
P + + Q+ G++++H V+H+ + + N+ + G VK+ D+ ++
Sbjct: 92 KQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARL 151
Query: 450 LADICKEDVFEQTRV--------RFSDNALPYKTGKKGDVWRLGLLLLSL 491
L++ F T V +N LPY K D+W LG +L L
Sbjct: 152 LSN---PMAFACTYVGTPYYVPPEIWEN-LPY--NNKSDIWSLGCILYEL 195
Score = 38.9 bits (89), Expect = 0.042
Identities = 17/63 (26%), Positives = 37/63 (58%)
Query: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENI 648
++ L+++G+G+FG + VQ++ +A+K I + + + + E LL+++ H NI
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNI 62
Query: 649 VRY 651
V +
Sbjct: 63 VAF 65
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 87.4 bits (215), Expect = 1e-16
Identities = 66/210 (31%), Positives = 100/210 (47%), Gaps = 33/210 (15%)
Query: 793 EAVHYLYIQMEYCEKSTLRDTIDQGLYR----DTVRLWRLFREILDGLAYIHEKGMIHRD 848
EA +LYI MEYC+ L I Q + D + W F ++ G+ +IH+K ++HRD
Sbjct: 70 EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNW--FTQMCLGVNHIHKKRVLHRD 127
Query: 849 LKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYV 908
+K NIFL + VK+GDFG A + S+P VGT YV
Sbjct: 128 IKSKNIFLTQNGKVKLGDFGSAR------------------LLSNPMAFACTYVGTPYYV 169
Query: 909 SPEVQGSTKSAYNQKVDLFSLGIIFFEMS--YHPMVTASERIFVLNQLRDPTSPKFPEDF 966
PE+ + YN K D++SLG I +E+ HP S + +L + SP P +
Sbjct: 170 PPEIWENL--PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISP-LPSHY 226
Query: 967 DDGEHAKQKSVISWLLNHDPAKRPTATELL 996
+ + ++ + +P+ RP+AT LL
Sbjct: 227 S----YELQFLVKQMFKRNPSHRPSATTLL 252
Score = 47.8 bits (112), Expect = 9e-05
Identities = 40/170 (23%), Positives = 73/170 (42%), Gaps = 20/170 (11%)
Query: 332 KIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHL 391
++ K Q + E L K+ HPN+V + E + I++E+ G L +
Sbjct: 36 RLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGH----LYIVMEYCDGGDLMQKI 91
Query: 392 SHSGP--IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKR 449
P + + Q+ G++++H V+H+ + + N+ + G VK+ D+ ++
Sbjct: 92 KQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARL 151
Query: 450 LADICKEDVFEQTRV--------RFSDNALPYKTGKKGDVWRLGLLLLSL 491
L++ F T V +N LPY K D+W LG +L L
Sbjct: 152 LSN---PMAFACTYVGTPYYVPPEIWEN-LPY--NNKSDIWSLGCILYEL 195
Score = 38.9 bits (89), Expect = 0.042
Identities = 17/63 (26%), Positives = 37/63 (58%)
Query: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENI 648
++ L+++G+G+FG + VQ++ +A+K I + + + + E LL+++ H NI
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNI 62
Query: 649 VRY 651
V +
Sbjct: 63 VAF 65
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 85.9 bits (211), Expect = 3e-16
Identities = 64/194 (32%), Positives = 95/194 (48%), Gaps = 34/194 (17%)
Query: 828 LFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTG 887
+ RE+L+GL Y+H+ G IHRD+K NI L D V+I DFG++ AF A G
Sbjct: 126 ILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVS----AFLATG------G 175
Query: 888 DLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMS--------YH 939
D+ ++ VGT +++PEV + Y+ K D++S GI E++ Y
Sbjct: 176 DITRNKVR---KTFVGTPCWMAPEVMEQVR-GYDFKADIWSFGITAIELATGAAPYHKYP 231
Query: 940 PMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQ-----KSVISWLLNHDPAKRPTATE 994
PM ++ +L DP P D E K+ + +IS L DP KRPTA E
Sbjct: 232 PM-----KVLMLTLQNDP--PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAE 284
Query: 995 LLKSELLPPPQMEE 1008
LL+ + + +E
Sbjct: 285 LLRHKFFQKAKNKE 298
Score = 72.8 bits (177), Expect = 3e-12
Identities = 59/245 (24%), Positives = 110/245 (44%), Gaps = 43/245 (17%)
Query: 333 IDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS 392
++KC+ + E ++ + HPN+V Y + + + +V+ +L SG S+ +
Sbjct: 50 LEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLL----SGGSVLDIIK 105
Query: 393 H--------SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDY 444
H SG + + ++L GL+YLH N +H+ + A N+L+ +G+V+I D+
Sbjct: 106 HIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADF 165
Query: 445 SISKRLA---DICKEDV---FEQTRVRFSDNALPYKTGK--KGDVWRLGLLLLSLSQG-Q 495
+S LA DI + V F T + + G K D+W G+ + L+ G
Sbjct: 166 GVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAA 225
Query: 496 ECGEYP------VTIPSDLPA----------------DFQDFLKKCVCLDDKERWSPQQL 533
+YP +T+ +D P+ F+ + C+ D ++R + +L
Sbjct: 226 PYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL 285
Query: 534 LKHSF 538
L+H F
Sbjct: 286 LRHKF 290
Score = 36.6 bits (83), Expect = 0.21
Identities = 19/72 (26%), Positives = 34/72 (47%)
Query: 589 EFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENI 648
++E +++G GA V A+KRI + + E+ +S+ HH NI
Sbjct: 16 DYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNI 75
Query: 649 VRYYNAWIERHE 660
V YY +++ + E
Sbjct: 76 VSYYTSFVVKDE 87
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,268,070
Number of Sequences: 37866
Number of extensions: 3204346
Number of successful extensions: 30368
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 875
Number of HSP's successfully gapped in prelim test: 601
Number of HSP's that attempted gapping in prelim test: 17179
Number of HSP's gapped (non-prelim): 9425
length of query: 1649
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1533
effective length of database: 13,855,062
effective search space: 21239810046
effective search space used: 21239810046
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.