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Search of human proteins with 63025196
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63025196 serine arginine rich protein-specific kinase 3
[Homo sapiens]
(567 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63025196 serine arginine rich protein-specific kinase 3 [Homo... 1160 0.0
gi|33188449 serine/arginine-rich protein-specific kinase 2 isofo... 428 e-120
gi|33188447 serine/arginine-rich protein-specific kinase 2 isofo... 428 e-120
gi|47419936 SFRS protein kinase 1 [Homo sapiens] 404 e-113
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 96 7e-20
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 96 7e-20
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 91 4e-18
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 91 4e-18
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 88 2e-17
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 88 2e-17
gi|10190706 CDC-like kinase 4 [Homo sapiens] 88 2e-17
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 87 4e-17
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 87 4e-17
gi|47717134 CDC-like kinase 2 [Homo sapiens] 85 2e-16
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 79 1e-14
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 77 6e-14
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 77 6e-14
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 77 6e-14
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 77 6e-14
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 77 6e-14
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 74 3e-13
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 74 3e-13
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 74 4e-13
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 74 5e-13
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 74 5e-13
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 68 2e-11
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 65 2e-10
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 65 2e-10
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 62 1e-09
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 62 1e-09
>gi|63025196 serine arginine rich protein-specific kinase 3 [Homo
sapiens]
Length = 567
Score = 1160 bits (3002), Expect = 0.0
Identities = 567/567 (100%), Positives = 567/567 (100%)
Query: 1 MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKD 60
MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKD
Sbjct: 1 MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKD 60
Query: 61 YCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETA 120
YCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETA
Sbjct: 61 YCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETA 120
Query: 121 VDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNY 180
VDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNY
Sbjct: 121 VDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNY 180
Query: 181 QGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQA 240
QGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQA
Sbjct: 181 QGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQA 240
Query: 241 GAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQ 300
GAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQ
Sbjct: 241 GAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQ 300
Query: 301 AEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSP 360
AEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSP
Sbjct: 301 AEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSP 360
Query: 361 ASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHF 420
ASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHF
Sbjct: 361 ASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHF 420
Query: 421 TEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAH 480
TEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAH
Sbjct: 421 TEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAH 480
Query: 481 IVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSA 540
IVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSA
Sbjct: 481 IVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSA 540
Query: 541 FLLPMMEYIPEKRASAADCLQHPWLNP 567
FLLPMMEYIPEKRASAADCLQHPWLNP
Sbjct: 541 FLLPMMEYIPEKRASAADCLQHPWLNP 567
>gi|33188449 serine/arginine-rich protein-specific kinase 2 isoform
a [Homo sapiens]
Length = 699
Score = 428 bits (1100), Expect = e-120
Identities = 197/253 (77%), Positives = 231/253 (91%), Gaps = 1/253 (0%)
Query: 41 PQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQ 100
P+ + +LGSDDEEQEDP DYCKGGYHPVKIGD+FNGRYHV+RKLGWGHFSTVWLCWD+Q
Sbjct: 54 PEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ 113
Query: 101 RKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHV 160
KRFVA+KVVKSA HYTETA+DEIKLLKCVR+SDPSDP ++ +VQLIDDF+ISG+NG+HV
Sbjct: 114 GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV 173
Query: 161 CMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL 220
CMV EVLGH LLKWIIKSNYQGLPV CVKSI+RQVL GLDYLH+KCKIIHTDIKPENIL+
Sbjct: 174 CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
Query: 221 CVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKR 280
CV DAY+RR+AAEATEWQ+AGAPPPS S VSTAPQ+ GK+SKNK+KK+++K+K+Q
Sbjct: 234 CVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQ-KPIGKISKNKKKKLKKKQKRQAE 292
Query: 281 LLEERLRDLQRLE 293
LLE+RL++++ LE
Sbjct: 293 LLEKRLQEIEELE 305
Score = 321 bits (822), Expect = 1e-87
Identities = 161/235 (68%), Positives = 181/235 (77%), Gaps = 20/235 (8%)
Query: 350 TSGFSGSLFSPASCSILSGSSNQRE------------------TGGLLSPSTPFGASNLL 391
TS FSGSL A S+LS S E TG L P A++LL
Sbjct: 466 TSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDL--PKAKTRAADLL 523
Query: 392 VNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTAC 451
VNPL+P+NADKI++KIADLGNACWVHKHFTEDIQTRQYR++EVLIGA Y PADIWSTAC
Sbjct: 524 VNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTAC 583
Query: 452 MAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRH 511
MAFELATGDYLFEPHSGEDYSRDEDHIAHI+ELLG IP FALSG+YSREFFNRRGELRH
Sbjct: 584 MAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH 643
Query: 512 IHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN 566
I LK W L++VL+EKY WP E A QF+ FL+PM+E +PEKRASA +CL+HPWLN
Sbjct: 644 ITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
>gi|33188447 serine/arginine-rich protein-specific kinase 2 isoform
b [Homo sapiens]
Length = 688
Score = 428 bits (1100), Expect = e-120
Identities = 197/253 (77%), Positives = 231/253 (91%), Gaps = 1/253 (0%)
Query: 41 PQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQ 100
P+ + +LGSDDEEQEDP DYCKGGYHPVKIGD+FNGRYHV+RKLGWGHFSTVWLCWD+Q
Sbjct: 43 PEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ 102
Query: 101 RKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHV 160
KRFVA+KVVKSA HYTETA+DEIKLLKCVR+SDPSDP ++ +VQLIDDF+ISG+NG+HV
Sbjct: 103 GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV 162
Query: 161 CMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL 220
CMV EVLGH LLKWIIKSNYQGLPV CVKSI+RQVL GLDYLH+KCKIIHTDIKPENIL+
Sbjct: 163 CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
Query: 221 CVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKR 280
CV DAY+RR+AAEATEWQ+AGAPPPS S VSTAPQ+ GK+SKNK+KK+++K+K+Q
Sbjct: 223 CVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQ-KPIGKISKNKKKKLKKKQKRQAE 281
Query: 281 LLEERLRDLQRLE 293
LLE+RL++++ LE
Sbjct: 282 LLEKRLQEIEELE 294
Score = 321 bits (822), Expect = 1e-87
Identities = 161/235 (68%), Positives = 181/235 (77%), Gaps = 20/235 (8%)
Query: 350 TSGFSGSLFSPASCSILSGSSNQRE------------------TGGLLSPSTPFGASNLL 391
TS FSGSL A S+LS S E TG L P A++LL
Sbjct: 455 TSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDL--PKAKTRAADLL 512
Query: 392 VNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTAC 451
VNPL+P+NADKI++KIADLGNACWVHKHFTEDIQTRQYR++EVLIGA Y PADIWSTAC
Sbjct: 513 VNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTAC 572
Query: 452 MAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRH 511
MAFELATGDYLFEPHSGEDYSRDEDHIAHI+ELLG IP FALSG+YSREFFNRRGELRH
Sbjct: 573 MAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH 632
Query: 512 IHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN 566
I LK W L++VL+EKY WP E A QF+ FL+PM+E +PEKRASA +CL+HPWLN
Sbjct: 633 ITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
>gi|47419936 SFRS protein kinase 1 [Homo sapiens]
Length = 655
Score = 404 bits (1039), Expect = e-113
Identities = 189/273 (69%), Positives = 230/273 (84%), Gaps = 1/273 (0%)
Query: 21 SQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYH 80
+Q + GS + +P+ + +LGSDD+EQEDP DYCKGGYH VKIGD+FNGRYH
Sbjct: 22 AQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYH 81
Query: 81 VVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKR 140
V+RKLGWGHFSTVWL WDIQ K+FVA+KVVKSA HYTETA+DEI+LLK VR+SDP+DP R
Sbjct: 82 VIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNR 141
Query: 141 ETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLD 200
E +VQL+DDF+ISGVNG H+CMV EVLGH LLKWIIKSNYQGLP+PCVK I++QVL GLD
Sbjct: 142 EMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLD 201
Query: 201 YLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQT 260
YLHTKC+IIHTDIKPENILL V + YIRRLAAEATEWQ++GAPPPS S VSTAPQ
Sbjct: 202 YLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQP-KPA 260
Query: 261 GKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLE 293
K+SKNK+KK+++K+K+Q LLE+R+++++ +E
Sbjct: 261 DKMSKNKKKKLKKKQKRQAELLEKRMQEIEEME 293
Score = 298 bits (762), Expect = 1e-80
Identities = 151/267 (56%), Positives = 187/267 (70%), Gaps = 8/267 (2%)
Query: 302 EDSGLRLDGGSGSTS--SSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFS 359
E S L G STS + C P + + S + G +S S S S+ +
Sbjct: 394 ESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVG-QSFSE-QHISQLQESIRA 451
Query: 360 PASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKH 419
C ++E G L A N LVNPLEP+NA+K+K+KIADLGNACWVHKH
Sbjct: 452 EIPCE----DEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH 507
Query: 420 FTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA 479
FTEDIQTRQYR++EVLIG+ Y PADIWSTACMAFELATGDYLFEPHSGE+Y+RDEDHIA
Sbjct: 508 FTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIA 567
Query: 480 HIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFS 539
I+ELLG +P ++G+YS+EFF ++G+L+HI LK WGL+EVL+EKYEW E+A F+
Sbjct: 568 LIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFT 627
Query: 540 AFLLPMMEYIPEKRASAADCLQHPWLN 566
FLLPM+E IPEKRA+AA+CL+HPWLN
Sbjct: 628 DFLLPMLELIPEKRATAAECLRHPWLN 654
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 96.3 bits (238), Expect = 7e-20
Identities = 58/158 (36%), Positives = 89/158 (56%), Gaps = 8/158 (5%)
Query: 63 KGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQR-KRFVALKVVKSAGHYTETAV 121
K G+ +IGD RY +V LG G F V C D R K VALK++++ G Y E A
Sbjct: 288 KEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAAR 347
Query: 122 DEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQ 181
EI +LK +++ D + + V + D F G H+C+ E+LG +++ ++N+Q
Sbjct: 348 LEINVLKKIKEKDKEN--KFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQ 401
Query: 182 GLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENIL 219
P+P V+ + Q+ H L +LH ++ HTD+KPENIL
Sbjct: 402 PYPLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENIL 438
Score = 72.0 bits (175), Expect = 1e-12
Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 26/180 (14%)
Query: 396 EPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFE 455
E ++ I++AD G+A + H+H T + TR YR EV++ + P D+WS C+ FE
Sbjct: 455 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 514
Query: 456 LATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFF-------NRRGE 508
G LF+ H + +H+ + ++LG IP R + F+ +
Sbjct: 515 YYRGFTLFQTH------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 568
Query: 509 LRHIHN----LKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPW 564
R++ LK + L + L + Q + M+E+ P +R + A+ L HP+
Sbjct: 569 GRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLHPF 619
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 96.3 bits (238), Expect = 7e-20
Identities = 58/158 (36%), Positives = 89/158 (56%), Gaps = 8/158 (5%)
Query: 63 KGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQR-KRFVALKVVKSAGHYTETAV 121
K G+ +IGD RY +V LG G F V C D R K VALK++++ G Y E A
Sbjct: 140 KEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAAR 199
Query: 122 DEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQ 181
EI +LK +++ D + + V + D F G H+C+ E+LG +++ ++N+Q
Sbjct: 200 LEINVLKKIKEKDKEN--KFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQ 253
Query: 182 GLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENIL 219
P+P V+ + Q+ H L +LH ++ HTD+KPENIL
Sbjct: 254 PYPLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENIL 290
Score = 72.0 bits (175), Expect = 1e-12
Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 26/180 (14%)
Query: 396 EPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFE 455
E ++ I++AD G+A + H+H T + TR YR EV++ + P D+WS C+ FE
Sbjct: 307 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 366
Query: 456 LATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFF-------NRRGE 508
G LF+ H + +H+ + ++LG IP R + F+ +
Sbjct: 367 YYRGFTLFQTH------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 420
Query: 509 LRHIHN----LKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPW 564
R++ LK + L + L + Q + M+E+ P +R + A+ L HP+
Sbjct: 421 GRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLHPF 471
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 90.5 bits (223), Expect = 4e-18
Identities = 60/188 (31%), Positives = 97/188 (51%), Gaps = 11/188 (5%)
Query: 33 ELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFST 92
E+ P + G++G + D D G Y V D RY V++ +G G F
Sbjct: 147 EIYFVGPNAKKRHGVIGGPNNGGYDDAD---GAYIHVP-RDHLAYRYEVLKIIGKGSFGQ 202
Query: 93 VWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRI 152
V +D + +++VALK+V++ + A +EI++L+ ++ D + ++ +++ F
Sbjct: 203 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN--VIHMLESFTF 260
Query: 153 SGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTD 212
HVCM E+L L + I K+ +QG V V+ + +L LD LH K KIIH D
Sbjct: 261 RN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCD 315
Query: 213 IKPENILL 220
+KPENILL
Sbjct: 316 LKPENILL 323
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/202 (29%), Positives = 89/202 (44%), Gaps = 44/202 (21%)
Query: 395 LEPQNA-----DKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWST 449
L+P+N + K+ D G++C+ ++ IQ+R YRA E+++G+ Y P DIWS
Sbjct: 316 LKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSF 375
Query: 450 ACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFN----- 504
C+ EL TG LF GED + D +A ++ELLG PP + ++ F N
Sbjct: 376 GCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 429
Query: 505 --------------------RRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLP 544
RRG+ R K WG + Y F FL
Sbjct: 430 RYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY--------LFIEFLKR 481
Query: 545 MMEYIPEKRASAADCLQHPWLN 566
+ + P R + A L+HPW++
Sbjct: 482 CLHWDPSARLTPAQALRHPWIS 503
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 90.5 bits (223), Expect = 4e-18
Identities = 60/188 (31%), Positives = 97/188 (51%), Gaps = 11/188 (5%)
Query: 33 ELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFST 92
E+ P + G++G + D D G Y V D RY V++ +G G F
Sbjct: 167 EIYFVGPNAKKRHGVIGGPNNGGYDDAD---GAYIHVP-RDHLAYRYEVLKIIGKGSFGQ 222
Query: 93 VWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRI 152
V +D + +++VALK+V++ + A +EI++L+ ++ D + ++ +++ F
Sbjct: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN--VIHMLESFTF 280
Query: 153 SGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTD 212
HVCM E+L L + I K+ +QG V V+ + +L LD LH K KIIH D
Sbjct: 281 RN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCD 335
Query: 213 IKPENILL 220
+KPENILL
Sbjct: 336 LKPENILL 343
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/202 (29%), Positives = 89/202 (44%), Gaps = 44/202 (21%)
Query: 395 LEPQNA-----DKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWST 449
L+P+N + K+ D G++C+ ++ IQ+R YRA E+++G+ Y P DIWS
Sbjct: 336 LKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSF 395
Query: 450 ACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFN----- 504
C+ EL TG LF GED + D +A ++ELLG PP + ++ F N
Sbjct: 396 GCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 449
Query: 505 --------------------RRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLP 544
RRG+ R K WG + Y F FL
Sbjct: 450 RYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY--------LFIEFLKR 501
Query: 545 MMEYIPEKRASAADCLQHPWLN 566
+ + P R + A L+HPW++
Sbjct: 502 CLHWDPSARLTPAQALRHPWIS 523
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 87.8 bits (216), Expect = 2e-17
Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 7/143 (4%)
Query: 78 RYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSD 137
RY V++ +G G F V +D + + VALK+V++ + A +EI++L+ +R D +
Sbjct: 221 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 280
Query: 138 PKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLH 197
++ ++++F H+CM E+L L + I K+ +QG +P V+ +L
Sbjct: 281 TMN--VIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 334
Query: 198 GLDYLHTKCKIIHTDIKPENILL 220
LD LH K +IIH D+KPENILL
Sbjct: 335 CLDALH-KNRIIHCDLKPENILL 356
Score = 79.3 bits (194), Expect = 9e-15
Identities = 58/186 (31%), Positives = 86/186 (46%), Gaps = 39/186 (20%)
Query: 405 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFE 464
IK+ D G++C+ H+ IQ+R YRA EV++GA YG P D+WS C+ EL TG L
Sbjct: 364 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLL- 422
Query: 465 PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFF--------------------- 503
GED + D +A ++ELLG + + ++ F
Sbjct: 423 --PGED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVL 477
Query: 504 ----NRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADC 559
+RRG+LR + WG ++ + PL F FL +E+ P R +
Sbjct: 478 NGGRSRRGKLRGPPESREWG---NALKGCDDPL-----FLDFLKQCLEWDPAVRMTPGQA 529
Query: 560 LQHPWL 565
L+HPWL
Sbjct: 530 LRHPWL 535
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 87.8 bits (216), Expect = 2e-17
Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 7/143 (4%)
Query: 78 RYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSD 137
RY V++ +G G F V +D + + VALK+V++ + A +EI++L+ +R D +
Sbjct: 148 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 207
Query: 138 PKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLH 197
++ ++++F H+CM E+L L + I K+ +QG +P V+ +L
Sbjct: 208 TMN--VIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 261
Query: 198 GLDYLHTKCKIIHTDIKPENILL 220
LD LH K +IIH D+KPENILL
Sbjct: 262 CLDALH-KNRIIHCDLKPENILL 283
Score = 79.3 bits (194), Expect = 9e-15
Identities = 58/186 (31%), Positives = 86/186 (46%), Gaps = 39/186 (20%)
Query: 405 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFE 464
IK+ D G++C+ H+ IQ+R YRA EV++GA YG P D+WS C+ EL TG L
Sbjct: 291 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLL- 349
Query: 465 PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFF--------------------- 503
GED + D +A ++ELLG + + ++ F
Sbjct: 350 --PGED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVL 404
Query: 504 ----NRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADC 559
+RRG+LR + WG ++ + PL F FL +E+ P R +
Sbjct: 405 NGGRSRRGKLRGPPESREWG---NALKGCDDPL-----FLDFLKQCLEWDPAVRMTPGQA 456
Query: 560 LQHPWL 565
L+HPWL
Sbjct: 457 LRHPWL 462
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 87.8 bits (216), Expect = 2e-17
Identities = 59/179 (32%), Positives = 93/179 (51%), Gaps = 18/179 (10%)
Query: 51 DDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRF-VALKV 109
DDEE G+ + GDV RY +V LG G F V C D VA+K+
Sbjct: 141 DDEE----------GHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKI 190
Query: 110 VKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH 169
VK+ G Y E A EI++L+ + +DP+ R VQ+++ F G HVC+V E+LG
Sbjct: 191 VKNVGRYREAARSEIQVLEHLNSTDPNSVFR--CVQMLEWFDHHG----HVCIVFELLGL 244
Query: 170 QLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIR 228
+I ++++ + ++ + Q+ +++LH K+ HTD+KPENIL D ++
Sbjct: 245 STYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHN-KLTHTDLKPENILFVKSDYVVK 302
Score = 68.9 bits (167), Expect = 1e-11
Identities = 48/173 (27%), Positives = 79/173 (45%), Gaps = 26/173 (15%)
Query: 405 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFE 464
IK+ D G+A + +H + + TR YRA EV++ + P D+WS C+ E G +F+
Sbjct: 319 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQ 378
Query: 465 PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHW------ 518
H ++H+A + +LG IP R R++F+ HN W
Sbjct: 379 THD------SKEHLAMMERILGPIPQHMIQKTR-KRKYFH--------HNQLDWDEHSSA 423
Query: 519 GLY-----EVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN 566
G Y + L E E+ + + M+EY P +R + + LQHP+ +
Sbjct: 424 GRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 87.0 bits (214), Expect = 4e-17
Identities = 58/175 (33%), Positives = 93/175 (53%), Gaps = 18/175 (10%)
Query: 51 DDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK-RFVALKV 109
DDEE G+ + GDV + RY +V LG G F V C D + R VA+K+
Sbjct: 185 DDEE----------GHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 234
Query: 110 VKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH 169
VK+ Y E A EI++L+ + +DP+ R VQ+++ F G H+C+V E+LG
Sbjct: 235 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGL 288
Query: 170 QLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGD 224
+I ++ + + ++ + Q+ +++LH+ K+ HTD+KPENIL D
Sbjct: 289 STYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQSD 342
Score = 66.6 bits (161), Expect = 6e-11
Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 10/165 (6%)
Query: 405 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFE 464
IK+ D G+A + +H + + TR YRA EV++ + P D+WS C+ E G +F
Sbjct: 363 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 422
Query: 465 PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVL 524
H ++H+A + +LG +P R + F + R + H+ +
Sbjct: 423 THD------SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDE-HSSAGRYVSRRC 475
Query: 525 MEKYEWPLEQATQFSA---FLLPMMEYIPEKRASAADCLQHPWLN 566
E+ L Q + + M+EY P KR + + L+HP+ +
Sbjct: 476 KPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 520
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 87.0 bits (214), Expect = 4e-17
Identities = 58/175 (33%), Positives = 93/175 (53%), Gaps = 18/175 (10%)
Query: 51 DDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK-RFVALKV 109
DDEE G+ + GDV + RY +V LG G F V C D + R VA+K+
Sbjct: 143 DDEE----------GHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 192
Query: 110 VKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH 169
VK+ Y E A EI++L+ + +DP+ R VQ+++ F G H+C+V E+LG
Sbjct: 193 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGL 246
Query: 170 QLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGD 224
+I ++ + + ++ + Q+ +++LH+ K+ HTD+KPENIL D
Sbjct: 247 STYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQSD 300
Score = 66.6 bits (161), Expect = 6e-11
Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 10/165 (6%)
Query: 405 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFE 464
IK+ D G+A + +H + + TR YRA EV++ + P D+WS C+ E G +F
Sbjct: 321 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 380
Query: 465 PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVL 524
H ++H+A + +LG +P R + F + R + H+ +
Sbjct: 381 THD------SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDE-HSSAGRYVSRRC 433
Query: 525 MEKYEWPLEQATQFSA---FLLPMMEYIPEKRASAADCLQHPWLN 566
E+ L Q + + M+EY P KR + + L+HP+ +
Sbjct: 434 KPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 478
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 85.1 bits (209), Expect = 2e-16
Identities = 56/160 (35%), Positives = 83/160 (51%), Gaps = 11/160 (6%)
Query: 66 YHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRF-VALKVVKSAGHYTETAVDEI 124
YH +GD RY +V LG G F V C D +R VALK++K+ Y E A EI
Sbjct: 152 YH---VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEI 208
Query: 125 KLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLP 184
+L+ + + DP + + VQ+ D F G H+C+ E+LG ++ +NY P
Sbjct: 209 NVLEKINEKDPDN--KNLCVQMFDWFDYHG----HMCISFELLGLSTFDFLKDNNYLPYP 262
Query: 185 VPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGD 224
+ V+ + Q+ + +LH K+ HTD+KPENIL D
Sbjct: 263 IHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVNSD 301
Score = 80.1 bits (196), Expect = 5e-15
Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 14/165 (8%)
Query: 405 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFE 464
+++ D G+A + H+H + + TR YRA EV++ + P D+WS C+ FE G LF+
Sbjct: 322 VRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQ 381
Query: 465 PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLY--- 521
H + +H+A + +LG IP R + F+ RG L N G Y
Sbjct: 382 THD------NREHLAMMERILGPIPSRMIRKTRKQKYFY--RGRLDWDENTSA-GRYVRE 432
Query: 522 --EVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPW 564
+ L E+ Q + M+EY P KR + + LQHP+
Sbjct: 433 NCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 78.6 bits (192), Expect = 1e-14
Identities = 49/156 (31%), Positives = 80/156 (51%), Gaps = 7/156 (4%)
Query: 65 GYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEI 124
G++ + D RY V+ +G G F V C D + VALK++++ + + A+ E+
Sbjct: 90 GFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMEL 149
Query: 125 KLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLP 184
K+L+ +R D + +V + D F H C+ E+LG L + + +N+QG
Sbjct: 150 KILEALRKKDKDN--TYNVVHMKDFFYFRN----HFCITFELLGINLYELMKNNNFQGFS 203
Query: 185 VPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL 220
+ V+ VL L L + KIIH D+KPENI+L
Sbjct: 204 LSIVRRFTLSVLKCLQMLSVE-KIIHCDLKPENIVL 238
Score = 73.9 bits (180), Expect = 4e-13
Identities = 52/183 (28%), Positives = 91/183 (49%), Gaps = 23/183 (12%)
Query: 395 LEPQNA-----DKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWST 449
L+P+N + +K+ D G++C+ H+ IQ+R YR+ EV++G Y D+WS
Sbjct: 231 LKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSL 290
Query: 450 ACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGEL 509
C+ EL TG LF GE+ + + +A I+E+LG P F + + FF+ +G
Sbjct: 291 GCITAELYTGYPLF---PGEN---EVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFP 344
Query: 510 RHIHNLKHWGLY------EVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHP 563
++I N + Y ++++ Y+ T F FL + + P R + L+H
Sbjct: 345 KNITNNRGKKRYPDSKDLTMVLKTYD------TSFLDFLRRCLVWEPSLRMTPDQALKHA 398
Query: 564 WLN 566
W++
Sbjct: 399 WIH 401
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 76.6 bits (187), Expect = 6e-14
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 49 GSDDEEQEDPKDYCKGGY------HPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK 102
G D +++ K Y GY + VK G+ + RY + +G G F V +D +
Sbjct: 124 GDDSSHKKERKVY-NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQ 182
Query: 103 RFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCM 162
+VA+K++K+ + A E++LL+ + D + IV L F H+C+
Sbjct: 183 EWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCL 236
Query: 163 VLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
V E+L + L + +N++G+ + + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 237 VFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/108 (38%), Positives = 62/108 (57%), Gaps = 8/108 (7%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFAL-SGRYSREFFNR 505
G+ LF SG + + D + IVE+LG IPPA L +R+FF +
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLG-IPPAHILDQAPKARKFFEK 397
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 76.6 bits (187), Expect = 6e-14
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 49 GSDDEEQEDPKDYCKGGY------HPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK 102
G D +++ K Y GY + VK G+ + RY + +G G F V +D +
Sbjct: 124 GDDSSHKKERKVY-NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQ 182
Query: 103 RFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCM 162
+VA+K++K+ + A E++LL+ + D + IV L F H+C+
Sbjct: 183 EWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCL 236
Query: 163 VLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
V E+L + L + +N++G+ + + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 237 VFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/108 (38%), Positives = 62/108 (57%), Gaps = 8/108 (7%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFAL-SGRYSREFFNR 505
G+ LF SG + + D + IVE+LG IPPA L +R+FF +
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLG-IPPAHILDQAPKARKFFEK 397
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 76.6 bits (187), Expect = 6e-14
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 49 GSDDEEQEDPKDYCKGGY------HPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK 102
G D +++ K Y GY + VK G+ + RY + +G G F V +D +
Sbjct: 124 GDDSSHKKERKVY-NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQ 182
Query: 103 RFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCM 162
+VA+K++K+ + A E++LL+ + D + IV L F H+C+
Sbjct: 183 EWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCL 236
Query: 163 VLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
V E+L + L + +N++G+ + + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 237 VFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/108 (38%), Positives = 62/108 (57%), Gaps = 8/108 (7%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFAL-SGRYSREFFNR 505
G+ LF SG + + D + IVE+LG IPPA L +R+FF +
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLG-IPPAHILDQAPKARKFFEK 397
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 76.6 bits (187), Expect = 6e-14
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 49 GSDDEEQEDPKDYCKGGY------HPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK 102
G D +++ K Y GY + VK G+ + RY + +G G F V +D +
Sbjct: 115 GDDSSHKKERKVY-NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQ 173
Query: 103 RFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCM 162
+VA+K++K+ + A E++LL+ + D + IV L F H+C+
Sbjct: 174 EWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCL 227
Query: 163 VLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
V E+L + L + +N++G+ + + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 228 VFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 287
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/108 (38%), Positives = 62/108 (57%), Gaps = 8/108 (7%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 288 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 347
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFAL-SGRYSREFFNR 505
G+ LF SG + + D + IVE+LG IPPA L +R+FF +
Sbjct: 348 GEPLF---SG---ANEVDQMNKIVEVLG-IPPAHILDQAPKARKFFEK 388
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 76.6 bits (187), Expect = 6e-14
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 49 GSDDEEQEDPKDYCKGGY------HPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRK 102
G D +++ K Y GY + VK G+ + RY + +G G F V +D +
Sbjct: 124 GDDSSHKKERKVY-NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQ 182
Query: 103 RFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCM 162
+VA+K++K+ + A E++LL+ + D + IV L F H+C+
Sbjct: 183 EWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCL 236
Query: 163 VLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
V E+L + L + +N++G+ + + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 237 VFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/108 (38%), Positives = 62/108 (57%), Gaps = 8/108 (7%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFAL-SGRYSREFFNR 505
G+ LF SG + + D + IVE+LG IPPA L +R+FF +
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLG-IPPAHILDQAPKARKFFEK 397
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 74.3 bits (181), Expect = 3e-13
Identities = 56/165 (33%), Positives = 81/165 (49%), Gaps = 14/165 (8%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNR-RGELRHIHNLKH 517
G+ LF SG S + D + IVE+LG P A +R++F R G + K
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKE 362
Query: 518 WGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQH 562
L + Y+ P + Q +L M+EY P R S LQH
Sbjct: 363 ------LRKDYQGPGTRRLQ-EDLVLRMLEYEPAARISPLGALQH 400
Score = 73.6 bits (179), Expect = 5e-13
Identities = 46/154 (29%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
Query: 69 VKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLK 128
V+ G+ + RY + +G G F V +D Q + VA+K++K+ + A E++LL+
Sbjct: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
Query: 129 CVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCV 188
+ D + IV L F H+C+V E+L + L + ++++G+ +
Sbjct: 161 LMNQHDTE--MKYYIVHLKRHFMFRN----HLCLVFELLSYNLYDLLRNTHFRGVSLNLT 214
Query: 189 KSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
+ + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 215 RKLAQQLCTALLFLATPELSIIHCDLKPENILLC 248
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 74.3 bits (181), Expect = 3e-13
Identities = 57/177 (32%), Positives = 93/177 (52%), Gaps = 11/177 (6%)
Query: 48 LGSDDEEQEDPKDYCKG--GYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQR-KRF 104
+G D +E + +D GY+ V IG+V + RY+V G G FS V D R +
Sbjct: 654 IGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQE 713
Query: 105 VALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVL 164
VA+K++++ +T + E++ LK + D+DP D + ++L F + H+C+V
Sbjct: 714 VAVKIIRNNELMQKTGLKELEFLKKLNDADPDD--KFHCLRLFRHF----YHKQHLCLVF 767
Query: 165 EVLGHQLLKWIIKSNYQ-GLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL 220
E L L + + K GL + V+S +Q+ L L +C I+H DIKP+NIL+
Sbjct: 768 EPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLL-KRCNILHADIKPDNILV 823
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/130 (27%), Positives = 61/130 (46%), Gaps = 13/130 (10%)
Query: 389 NLLVNPLEPQNA----DKIKIKIADLGNACWVHKH-FTEDIQTRQYRAVEVLIGAEYGPP 443
N+L ++P N K +K+ D G+A V + T + +R YRA E++IG Y
Sbjct: 810 NILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYG 869
Query: 444 ADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHI-VELLGDIPPAFALSGRYSREF 502
D+WS C +EL TG LF + +H+ + ++L G +P G + +
Sbjct: 870 IDMWSVGCTLYELYTGKILFP-------GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQH 922
Query: 503 FNRRGELRHI 512
F++ +I
Sbjct: 923 FDQNLNFMYI 932
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 73.9 bits (180), Expect = 4e-13
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 13/153 (8%)
Query: 78 RYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVK------SAGHYTETAVDEIKLLKCVR 131
RY V ++G G + TV+ D FVALK V+ G + V E+ LL+ +
Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64
Query: 132 DSDPSDPKRETIVQLIDDFRISGVNG-VHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKS 190
+ +V+L+D S + + V +V E + L ++ K+ GLP +K
Sbjct: 65 AFE-----HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119
Query: 191 IVRQVLHGLDYLHTKCKIIHTDIKPENILLCVG 223
++RQ L GLD+LH C I+H D+KPENIL+ G
Sbjct: 120 LMRQFLRGLDFLHANC-IVHRDLKPENILVTSG 151
Score = 46.2 bits (108), Expect = 8e-05
Identities = 47/167 (28%), Positives = 73/167 (43%), Gaps = 29/167 (17%)
Query: 405 IKIADLGNACWVHKH---FTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDY 461
+K+AD G A ++ + T + T YRA EVL+ + Y P D+WS C+ E+
Sbjct: 154 VKLADFGLAR-IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKP 212
Query: 462 LFEPHSGEDYSRDEDHIAHIVELLGDIPPA--FALSGRYSREFFNRRGELRHIHNLKHWG 519
LF +S + D + I +L+G +PP + R F RG R + ++
Sbjct: 213 LFCGNS------EADQLGKIFDLIG-LPPEDDWPRDVSLPRGAFPPRGP-RPVQSVVP-- 262
Query: 520 LYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN 566
E + LL M+ + P KR SA LQH +L+
Sbjct: 263 -------------EMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 73.6 bits (179), Expect = 5e-13
Identities = 46/154 (29%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
Query: 69 VKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLK 128
V+ G+ + RY + +G G F V +D Q + VA+K++K+ + A E++LL+
Sbjct: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
Query: 129 CVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCV 188
+ D + IV L F H+C+V E+L + L + ++++G+ +
Sbjct: 161 LMNQHDTE--MKYYIVHLKRHFMFRN----HLCLVFELLSYNLYDLLRNTHFRGVSLNLT 214
Query: 189 KSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
+ + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 215 RKLAQQLCTALLFLATPELSIIHCDLKPENILLC 248
Score = 69.7 bits (169), Expect = 7e-12
Identities = 60/186 (32%), Positives = 86/186 (46%), Gaps = 28/186 (15%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNR----RGELRHIHN 514
G+ LF SG S + D + IVE+LG P A +R++F R LR
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKE 362
Query: 515 LK--HWG-----LYEVLMEKYEWPLEQAT-----------QFSAFLLPMMEYIPEKRASA 556
L+ + G L EVL + P + +F +L M+EY P R S
Sbjct: 363 LRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISP 422
Query: 557 ADCLQH 562
LQH
Sbjct: 423 LGALQH 428
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 73.6 bits (179), Expect = 5e-13
Identities = 46/154 (29%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
Query: 69 VKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLK 128
V+ G+ + RY + +G G F V +D Q + VA+K++K+ + A E++LL+
Sbjct: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
Query: 129 CVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCV 188
+ D + IV L F H+C+V E+L + L + ++++G+ +
Sbjct: 161 LMNQHDTE--MKYYIVHLKRHFMFRN----HLCLVFELLSYNLYDLLRNTHFRGVSLNLT 214
Query: 189 KSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC 221
+ + +Q+ L +L T + IIH D+KPENILLC
Sbjct: 215 RKLAQQLCTALLFLATPELSIIHCDLKPENILLC 248
Score = 72.0 bits (175), Expect = 1e-12
Identities = 52/165 (31%), Positives = 76/165 (46%), Gaps = 26/165 (15%)
Query: 399 NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELAT 458
N + IKI D G++C + + + IQ+R YR+ EVL+G Y D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 459 GDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHW 518
G+ LF SG S + D + IVE+LG P A +R++F R
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER------------- 349
Query: 519 GLYEVLMEKYEWPLEQATQF-SAFLLPMMEYIPEKRASAADCLQH 562
+ W L + + +L M+EY P R S LQH
Sbjct: 350 ------LPGGGWTLRRTKELRKDLVLRMLEYEPAARISPLGALQH 388
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 68.2 bits (165), Expect = 2e-11
Identities = 42/142 (29%), Positives = 74/142 (52%), Gaps = 8/142 (5%)
Query: 79 YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDP 138
Y ++ LG G F V W VA+K++K+ + +E+KLL C+R DP +
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Query: 139 KRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHG 198
+++ ++ F + + +V E+L L ++ ++N+ LP ++++ QVL
Sbjct: 71 H---VIRFLEFFH----DALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTA 123
Query: 199 LDYLHTKCKIIHTDIKPENILL 220
L L + IIH D+KPENI+L
Sbjct: 124 LARL-KELAIIHADLKPENIML 144
Score = 43.5 bits (101), Expect = 5e-04
Identities = 31/114 (27%), Positives = 53/114 (46%), Gaps = 9/114 (7%)
Query: 395 LEPQNADKIKIKIADLGNAC-WVHKHFTED--IQTRQYRAVEVLIGAEYGPPADIWSTAC 451
L Q ++K+ D G+A + + ++ IQ+R YRA E+L+G + D+WS C
Sbjct: 144 LVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGC 203
Query: 452 MAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNR 505
+ EL G L+ ++ + D + +I E G P + + FF R
Sbjct: 204 VMAELHLGWPLYPGNN------EYDQVRYICETQGLPKPHLLHAACKAHHFFKR 251
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 64.7 bits (156), Expect = 2e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 8/142 (5%)
Query: 79 YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDP 138
Y V+ LG G F V CW K VA+K++K+ Y E+ +L + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE- 248
Query: 139 KRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHG 198
V+ + F+ H C+V E+L L ++ ++ + LP+ ++ I++QV
Sbjct: 249 --YNFVRSYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302
Query: 199 LDYLHTKCKIIHTDIKPENILL 220
L L + +IH D+KPENI+L
Sbjct: 303 LMKLKS-LGLIHADLKPENIML 323
Score = 49.7 bits (117), Expect = 7e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 390 LLVNPLEPQNADKIKIKIADLGNACWVHKHFTED-IQTRQYRAVEVLIGAEYGPPADIWS 448
+LV+P+ ++K+ D G+A V K +Q+R YRA E+++G + D+WS
Sbjct: 322 MLVDPVR----QPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377
Query: 449 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALS-GRYSREFFNR 505
C+ EL G L+ S + D I +I + G +P + LS G + FFNR
Sbjct: 378 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQG-LPAEYLLSAGTKTTRFFNR 428
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 64.7 bits (156), Expect = 2e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 8/142 (5%)
Query: 79 YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDP 138
Y V+ LG G F V CW K VA+K++K+ Y E+ +L + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE- 248
Query: 139 KRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHG 198
V+ + F+ H C+V E+L L ++ ++ + LP+ ++ I++QV
Sbjct: 249 --YNFVRSYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302
Query: 199 LDYLHTKCKIIHTDIKPENILL 220
L L + +IH D+KPENI+L
Sbjct: 303 LMKLKS-LGLIHADLKPENIML 323
Score = 49.7 bits (117), Expect = 7e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 390 LLVNPLEPQNADKIKIKIADLGNACWVHKHFTED-IQTRQYRAVEVLIGAEYGPPADIWS 448
+LV+P+ ++K+ D G+A V K +Q+R YRA E+++G + D+WS
Sbjct: 322 MLVDPVR----QPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377
Query: 449 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALS-GRYSREFFNR 505
C+ EL G L+ S + D I +I + G +P + LS G + FFNR
Sbjct: 378 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQG-LPAEYLLSAGTKTTRFFNR 428
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 8/142 (5%)
Query: 79 YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDP 138
Y V+ LG G F V CW VA+K++K+ Y E+ +L + D
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD- 257
Query: 139 KRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHG 198
V+ + F+ H C+V E+L L ++ ++ + LP+ ++ +++QV
Sbjct: 258 --YNFVRAYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATA 311
Query: 199 LDYLHTKCKIIHTDIKPENILL 220
L L + +IH D+KPENI+L
Sbjct: 312 LMKLKS-LGLIHADLKPENIML 332
Score = 49.3 bits (116), Expect = 9e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 390 LLVNPLEPQNADKIKIKIADLGNACWVHKHFTED-IQTRQYRAVEVLIGAEYGPPADIWS 448
+LV+P + ++K+ D G+A V K +Q+R YRA E+++G + D+WS
Sbjct: 331 MLVDP----SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
Query: 449 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALS-GRYSREFFNR 505
C+ EL G L+ S + D I +I + G +P + LS G + FFNR
Sbjct: 387 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQG-LPAEYLLSAGTKTTRFFNR 437
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 8/142 (5%)
Query: 79 YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDP 138
Y V+ LG G F V CW VA+K++K+ Y E+ +L + D
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD- 257
Query: 139 KRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHG 198
V+ + F+ H C+V E+L L ++ ++ + LP+ ++ +++QV
Sbjct: 258 --YNFVRAYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATA 311
Query: 199 LDYLHTKCKIIHTDIKPENILL 220
L L + +IH D+KPENI+L
Sbjct: 312 LMKLKS-LGLIHADLKPENIML 332
Score = 49.3 bits (116), Expect = 9e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 390 LLVNPLEPQNADKIKIKIADLGNACWVHKHFTED-IQTRQYRAVEVLIGAEYGPPADIWS 448
+LV+P + ++K+ D G+A V K +Q+R YRA E+++G + D+WS
Sbjct: 331 MLVDP----SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
Query: 449 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALS-GRYSREFFNR 505
C+ EL G L+ S + D I +I + G +P + LS G + FFNR
Sbjct: 387 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQG-LPAEYLLSAGTKTTRFFNR 437
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,651,036
Number of Sequences: 37866
Number of extensions: 1257663
Number of successful extensions: 16685
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 259
Number of HSP's successfully gapped in prelim test: 647
Number of HSP's that attempted gapping in prelim test: 12376
Number of HSP's gapped (non-prelim): 4291
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.