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Search of human proteins with 62422563
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
(438 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 886 0.0
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 886 0.0
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 746 0.0
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 746 0.0
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 746 0.0
gi|29826329 p21-activated kinase 7 [Homo sapiens] 511 e-145
gi|24308191 p21-activated kinase 7 [Homo sapiens] 511 e-145
gi|191252782 p21-activated kinase 6 [Homo sapiens] 453 e-127
gi|191252780 p21-activated kinase 6 [Homo sapiens] 453 e-127
gi|9910476 p21-activated kinase 6 [Homo sapiens] 453 e-127
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 359 2e-99
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 359 2e-99
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 359 2e-99
gi|32483399 p21-activated kinase 2 [Homo sapiens] 358 7e-99
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 350 2e-96
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 349 2e-96
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 347 1e-95
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 341 7e-94
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 335 5e-92
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 200 2e-51
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 199 3e-51
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 192 5e-49
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 189 3e-48
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 189 3e-48
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 189 4e-48
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 187 2e-47
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 187 2e-47
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 186 3e-47
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 186 4e-47
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 186 4e-47
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 886 bits (2289), Expect = 0.0
Identities = 438/438 (100%), Positives = 438/438 (100%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAP 120
SIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAP
Sbjct: 61 SIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAP 120
Query: 121 PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTG 180
PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTG
Sbjct: 121 PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTG 180
Query: 181 IVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWV 240
IVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWV
Sbjct: 181 IVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWV 240
Query: 241 VMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 300
VMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR
Sbjct: 241 VMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 300
Query: 301 VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP 360
VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP
Sbjct: 301 VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP 360
Query: 361 PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 420
PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA
Sbjct: 361 PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 420
Query: 421 KAGPPASIVPLMRQNRTR 438
KAGPPASIVPLMRQNRTR
Sbjct: 421 KAGPPASIVPLMRQNRTR 438
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 886 bits (2289), Expect = 0.0
Identities = 438/438 (100%), Positives = 438/438 (100%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAP 120
SIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAP
Sbjct: 61 SIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAP 120
Query: 121 PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTG 180
PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTG
Sbjct: 121 PACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTG 180
Query: 181 IVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWV 240
IVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWV
Sbjct: 181 IVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWV 240
Query: 241 VMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 300
VMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR
Sbjct: 241 VMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 300
Query: 301 VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP 360
VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP
Sbjct: 301 VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP 360
Query: 361 PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 420
PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA
Sbjct: 361 PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 420
Query: 421 KAGPPASIVPLMRQNRTR 438
KAGPPASIVPLMRQNRTR
Sbjct: 421 KAGPPASIVPLMRQNRTR 438
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 746 bits (1925), Expect = 0.0
Identities = 370/371 (99%), Positives = 371/371 (100%)
Query: 68 KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127
+GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
Query: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
Query: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
Query: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
Query: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
Query: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
Query: 428 IVPLMRQNRTR 438
IVPLMRQNRTR
Sbjct: 581 IVPLMRQNRTR 591
Score = 145 bits (366), Expect = 7e-35
Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117
SIQPGAPK G G L + + S +R + R +P P A +
Sbjct: 61 SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
Query: 118 LAPPACTPAAPAVPGPPGPR 137
P A PG G R
Sbjct: 116 GMPEEPATTARGGPGKAGSR 135
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 746 bits (1925), Expect = 0.0
Identities = 370/371 (99%), Positives = 371/371 (100%)
Query: 68 KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127
+GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
Query: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
Query: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
Query: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
Query: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
Query: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
Query: 428 IVPLMRQNRTR 438
IVPLMRQNRTR
Sbjct: 581 IVPLMRQNRTR 591
Score = 145 bits (366), Expect = 7e-35
Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117
SIQPGAPK G G L + + S +R + R +P P A +
Sbjct: 61 SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
Query: 118 LAPPACTPAAPAVPGPPGPR 137
P A PG G R
Sbjct: 116 GMPEEPATTARGGPGKAGSR 135
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 746 bits (1925), Expect = 0.0
Identities = 370/371 (99%), Positives = 371/371 (100%)
Query: 68 KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127
+GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
Query: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
Query: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
Query: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
Query: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
Query: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
Query: 428 IVPLMRQNRTR 438
IVPLMRQNRTR
Sbjct: 581 IVPLMRQNRTR 591
Score = 145 bits (366), Expect = 7e-35
Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117
SIQPGAPK G G L + + S +R + R +P P A +
Sbjct: 61 SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
Query: 118 LAPPACTPAAPAVPGPPGPR 137
P A PG G R
Sbjct: 116 GMPEEPATTARGGPGKAGSR 135
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 511 bits (1317), Expect = e-145
Identities = 253/306 (82%), Positives = 276/306 (90%)
Query: 131 PGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 190
P P S ++P RVSHEQFRAALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +
Sbjct: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHT 471
Query: 191 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 250
GK VAVKKMDLRKQQRRELLFNEVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGAL
Sbjct: 472 GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL 531
Query: 251 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 310
TDIVTHTRMNEEQIA VCL+VL+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCA
Sbjct: 532 TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
Query: 311 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 370
QVSKEVP+RKSLVGTPYWMAPE+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+A
Sbjct: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQA 651
Query: 371 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 430
M+ IRD+LPPR+K+LHKVS L+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVP
Sbjct: 652 MRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 711
Query: 431 LMRQNR 436
LMRQ R
Sbjct: 712 LMRQYR 717
Score = 112 bits (280), Expect = 7e-25
Identities = 60/116 (51%), Positives = 78/116 (67%), Gaps = 9/116 (7%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
Query: 61 SIQPGAPK-----GEP-HDVAPNG--PSAGGLAIPQSSS-SSSRPPTRARGAPSPG 107
IQ K +P + + NG +++ +S+S PPT +GA S G
Sbjct: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 511 bits (1317), Expect = e-145
Identities = 253/306 (82%), Positives = 276/306 (90%)
Query: 131 PGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 190
P P S ++P RVSHEQFRAALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +
Sbjct: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHT 471
Query: 191 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 250
GK VAVKKMDLRKQQRRELLFNEVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGAL
Sbjct: 472 GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL 531
Query: 251 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 310
TDIVTHTRMNEEQIA VCL+VL+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCA
Sbjct: 532 TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
Query: 311 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 370
QVSKEVP+RKSLVGTPYWMAPE+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+A
Sbjct: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQA 651
Query: 371 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 430
M+ IRD+LPPR+K+LHKVS L+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVP
Sbjct: 652 MRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 711
Query: 431 LMRQNR 436
LMRQ R
Sbjct: 712 LMRQYR 717
Score = 112 bits (280), Expect = 7e-25
Identities = 60/116 (51%), Positives = 78/116 (67%), Gaps = 9/116 (7%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
Query: 61 SIQPGAPK-----GEP-HDVAPNG--PSAGGLAIPQSSS-SSSRPPTRARGAPSPG 107
IQ K +P + + NG +++ +S+S PPT +GA S G
Sbjct: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 453 bits (1166), Expect = e-127
Identities = 243/404 (60%), Positives = 284/404 (70%), Gaps = 42/404 (10%)
Query: 75 APNGPSAGGLAIPQSSSSSSRPP---------TRARGAPSP---GVLGPHASEPQLAPPA 122
AP S G +SS RPP +A+ PS G P + +P
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 123 CTPAAPAVPGPPGPRSPQREPQR------------------------------VSHEQFR 152
APA PG SP P+ V+HEQF+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 153 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 212
AAL++VVD GDPR LD+++KIGEGSTGIVC+A + SG+ VAVK MDLRKQQRRELLFN
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 213 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 272
EVVIMRDYQH NVVEMY SYLVG+ELWV+MEFL+GGALTDIV+ R+NEEQIA VC AVL
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
QAL+ LHAQGVIHRDIKSDSILLT DGRVKLSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 333 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 392
+ISR Y EVDIWSLGIMVIEMVDGEPPYF++ P++AMK +RD+ PP+LKN HKVSP L
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 393 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 436
+ FL+R+LVRDP +RATA ELL HPFL + G P +VPL++ R
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYR 675
Score = 89.0 bits (219), Expect = 8e-18
Identities = 55/125 (44%), Positives = 74/125 (59%), Gaps = 11/125 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ+++ ++ RRPKP+VDP+ IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
Query: 64 PGAPK------GEPHDVAPNG--PSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPH--A 113
K P D +G L++ S++ R PT R A S G+LG A
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
Query: 114 SEPQL 118
++P +
Sbjct: 124 TDPDM 128
Score = 30.0 bits (66), Expect = 4.3
Identities = 27/107 (25%), Positives = 41/107 (38%), Gaps = 25/107 (23%)
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEP 116
AC+ S PGA P G + G+ + S +RP + G+ + G + P
Sbjct: 197 ACLQSSPPGASP-------PTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSP 249
Query: 117 Q---------------LAPPACTPAAPAVPGPP---GPRSPQREPQR 145
+ L+ A P + + PGPP P S R PQ+
Sbjct: 250 KTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQK 296
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 453 bits (1166), Expect = e-127
Identities = 243/404 (60%), Positives = 284/404 (70%), Gaps = 42/404 (10%)
Query: 75 APNGPSAGGLAIPQSSSSSSRPP---------TRARGAPSP---GVLGPHASEPQLAPPA 122
AP S G +SS RPP +A+ PS G P + +P
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 123 CTPAAPAVPGPPGPRSPQREPQR------------------------------VSHEQFR 152
APA PG SP P+ V+HEQF+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 153 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 212
AAL++VVD GDPR LD+++KIGEGSTGIVC+A + SG+ VAVK MDLRKQQRRELLFN
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 213 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 272
EVVIMRDYQH NVVEMY SYLVG+ELWV+MEFL+GGALTDIV+ R+NEEQIA VC AVL
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
QAL+ LHAQGVIHRDIKSDSILLT DGRVKLSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 333 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 392
+ISR Y EVDIWSLGIMVIEMVDGEPPYF++ P++AMK +RD+ PP+LKN HKVSP L
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 393 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 436
+ FL+R+LVRDP +RATA ELL HPFL + G P +VPL++ R
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYR 675
Score = 89.0 bits (219), Expect = 8e-18
Identities = 55/125 (44%), Positives = 74/125 (59%), Gaps = 11/125 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ+++ ++ RRPKP+VDP+ IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
Query: 64 PGAPK------GEPHDVAPNG--PSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPH--A 113
K P D +G L++ S++ R PT R A S G+LG A
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
Query: 114 SEPQL 118
++P +
Sbjct: 124 TDPDM 128
Score = 30.0 bits (66), Expect = 4.3
Identities = 27/107 (25%), Positives = 41/107 (38%), Gaps = 25/107 (23%)
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEP 116
AC+ S PGA P G + G+ + S +RP + G+ + G + P
Sbjct: 197 ACLQSSPPGASP-------PTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSP 249
Query: 117 Q---------------LAPPACTPAAPAVPGPP---GPRSPQREPQR 145
+ L+ A P + + PGPP P S R PQ+
Sbjct: 250 KTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQK 296
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 453 bits (1166), Expect = e-127
Identities = 243/404 (60%), Positives = 284/404 (70%), Gaps = 42/404 (10%)
Query: 75 APNGPSAGGLAIPQSSSSSSRPP---------TRARGAPSP---GVLGPHASEPQLAPPA 122
AP S G +SS RPP +A+ PS G P + +P
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 123 CTPAAPAVPGPPGPRSPQREPQR------------------------------VSHEQFR 152
APA PG SP P+ V+HEQF+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 153 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 212
AAL++VVD GDPR LD+++KIGEGSTGIVC+A + SG+ VAVK MDLRKQQRRELLFN
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 213 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 272
EVVIMRDYQH NVVEMY SYLVG+ELWV+MEFL+GGALTDIV+ R+NEEQIA VC AVL
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
QAL+ LHAQGVIHRDIKSDSILLT DGRVKLSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 333 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 392
+ISR Y EVDIWSLGIMVIEMVDGEPPYF++ P++AMK +RD+ PP+LKN HKVSP L
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 393 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 436
+ FL+R+LVRDP +RATA ELL HPFL + G P +VPL++ R
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYR 675
Score = 89.0 bits (219), Expect = 8e-18
Identities = 55/125 (44%), Positives = 74/125 (59%), Gaps = 11/125 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ+++ ++ RRPKP+VDP+ IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
Query: 64 PGAPK------GEPHDVAPNG--PSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPH--A 113
K P D +G L++ S++ R PT R A S G+LG A
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
Query: 114 SEPQL 118
++P +
Sbjct: 124 TDPDM 128
Score = 30.0 bits (66), Expect = 4.3
Identities = 27/107 (25%), Positives = 41/107 (38%), Gaps = 25/107 (23%)
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEP 116
AC+ S PGA P G + G+ + S +RP + G+ + G + P
Sbjct: 197 ACLQSSPPGASP-------PTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSP 249
Query: 117 Q---------------LAPPACTPAAPAVPGPP---GPRSPQREPQR 145
+ L+ A P + + PGPP P S R PQ+
Sbjct: 250 KTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQK 296
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 359 bits (922), Expect = 2e-99
Identities = 199/470 (42%), Positives = 280/470 (59%), Gaps = 41/470 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDV 122
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTRARGAPSPGVLGPHAS 114
+ + SA G A P S+ ++S PP +
Sbjct: 123 LKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEE 182
Query: 115 EPQLAPPACTP-----------------AAPAVPG----PPGPRSP-----------QRE 142
+ PP P A+PAVP PP + QR+
Sbjct: 183 DENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRK 242
Query: 143 PQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR 202
+++ E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L+
Sbjct: 243 KSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ 302
Query: 203 KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEE 262
+Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E
Sbjct: 303 QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEG 362
Query: 263 QIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL 322
QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++
Sbjct: 363 QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 422
Query: 323 VGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 382
VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE PL+A+ +I N P L
Sbjct: 423 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 482
Query: 383 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 432
+N ++S + FL+R L D +R +A ELL+HPFL A P +S+ PL+
Sbjct: 483 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 359 bits (922), Expect = 2e-99
Identities = 199/470 (42%), Positives = 280/470 (59%), Gaps = 41/470 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDV 122
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTRARGAPSPGVLGPHAS 114
+ + SA G A P S+ ++S PP +
Sbjct: 123 LKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEE 182
Query: 115 EPQLAPPACTP-----------------AAPAVPG----PPGPRSP-----------QRE 142
+ PP P A+PAVP PP + QR+
Sbjct: 183 DENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRK 242
Query: 143 PQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR 202
+++ E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L+
Sbjct: 243 KSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ 302
Query: 203 KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEE 262
+Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E
Sbjct: 303 QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEG 362
Query: 263 QIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL 322
QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++
Sbjct: 363 QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 422
Query: 323 VGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 382
VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE PL+A+ +I N P L
Sbjct: 423 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 482
Query: 383 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 432
+N ++S + FL+R L D +R +A ELL+HPFL A P +S+ PL+
Sbjct: 483 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 359 bits (922), Expect = 2e-99
Identities = 199/470 (42%), Positives = 280/470 (59%), Gaps = 41/470 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDV 122
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTRARGAPSPGVLGPHAS 114
+ + SA G A P S+ ++S PP +
Sbjct: 123 LKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEE 182
Query: 115 EPQLAPPACTP-----------------AAPAVPG----PPGPRSP-----------QRE 142
+ PP P A+PAVP PP + QR+
Sbjct: 183 DENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRK 242
Query: 143 PQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR 202
+++ E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L+
Sbjct: 243 KSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ 302
Query: 203 KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEE 262
+Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E
Sbjct: 303 QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEG 362
Query: 263 QIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL 322
QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++
Sbjct: 363 QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 422
Query: 323 VGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 382
VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE PL+A+ +I N P L
Sbjct: 423 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 482
Query: 383 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 432
+N ++S + FL+R L D +R +A ELL+HPFL A P +S+ PL+
Sbjct: 483 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 358 bits (918), Expect = 7e-99
Identities = 196/458 (42%), Positives = 278/458 (60%), Gaps = 40/458 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 67 KEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLD- 125
Query: 57 ACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEP 116
+ K + P P G S P A+G +P V+ +
Sbjct: 126 -VLKFYDSNTVKQKYLSFTP--PEKDGFP-------SGTPALNAKGTEAPAVVTEEEDDD 175
Query: 117 Q-LAPPACTP------------AAPAVPGPPGPR---------SPQREPQRVSHEQFRAA 154
+ APP P VP P G Q++ +++ E+
Sbjct: 176 EETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEK 235
Query: 155 LQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEV 214
L+ +V GDP+ + KIG+G++G V AT + G+ VA+K+++L+KQ ++EL+ NE+
Sbjct: 236 LRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEI 295
Query: 215 VIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQA 274
++M++ ++ N+V +SYLVGDEL+VVME+L GG+LTD+VT T M+E QIAAVC LQA
Sbjct: 296 LVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQA 355
Query: 275 LSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI 334
L LHA VIHRDIKSD++LL +G VKL+DFGFCAQ++ E +R ++VGTPYWMAPE++
Sbjct: 356 LEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 415
Query: 335 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKG 394
+R YGP+VDIWSLGIM IEMV+GEPPY NE PL+A+ +I N P L+N K+SP +
Sbjct: 416 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRD 475
Query: 395 FLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 432
FL+R L D +R +A ELL+HPFL A P +S+ PL+
Sbjct: 476 FLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLI 513
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 350 bits (897), Expect = 2e-96
Identities = 194/467 (41%), Positives = 278/467 (59%), Gaps = 38/467 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDV 127
Query: 57 ACITSIQPGAPKGE----PHDVAPNGPSAGGLAIPQSSSSSSRPPTRAR------GAPSP 106
+ + + + A + S+ L + S + + PP A P
Sbjct: 128 LEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPP 187
Query: 107 GVLGPHASEPQ-------LAPPACTPAAPAVPGPPGPRS--------------PQREPQR 145
V+ P + + P TP P P Q++ +
Sbjct: 188 PVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPK 247
Query: 146 VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ 205
+S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L++Q
Sbjct: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
Query: 206 RRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 265
++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E QIA
Sbjct: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
Query: 266 AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT 325
AVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++VGT
Sbjct: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
Query: 326 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 385
PYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N P L+N
Sbjct: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
Query: 386 HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 432
K+S + FL+R L D +R +A ELL+H FL A P +S+ PL+
Sbjct: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLI 534
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 349 bits (896), Expect = 2e-96
Identities = 199/485 (41%), Positives = 280/485 (57%), Gaps = 56/485 (11%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIE---- 44
K K+R EIS PS+FEH +H GFD +FT G+P QW L++
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNI 122
Query: 45 ---ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTR 99
E + P+ ++D + + SA G A P S+ ++S PP
Sbjct: 123 TKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLA 182
Query: 100 ARGAPSPGVLGPHASEPQLAPPACTP-----------------AAPAVPG----PPGPRS 138
+ + PP P A+PAVP PP +
Sbjct: 183 PPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAEN 242
Query: 139 P-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
QR+ +++ E+ L+ +V GDP+ F KIG+G++G V A
Sbjct: 243 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302
Query: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L G
Sbjct: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Query: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
G+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFG
Sbjct: 363 GSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
Query: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
FCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE P
Sbjct: 423 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Query: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
L+A+ +I N P L+N ++S + FL+R L D +R +A ELL+HPFL A P +S
Sbjct: 483 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 542
Query: 428 IVPLM 432
+ PL+
Sbjct: 543 LTPLI 547
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 347 bits (890), Expect = 1e-95
Identities = 199/491 (40%), Positives = 280/491 (57%), Gaps = 62/491 (12%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
Query: 43 IE-------ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSS 93
++ E + P+ ++D + + SA G A P S+ ++
Sbjct: 123 LQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTA 182
Query: 94 SRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AAPAVPG---- 132
S PP + + PP P A+PAVP
Sbjct: 183 SEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVT 242
Query: 133 PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGI 181
PP + QR+ +++ E+ L+ +V GDP+ F KIG+G++G
Sbjct: 243 PPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGT 302
Query: 182 VCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVV 241
V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVV
Sbjct: 303 VYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 362
Query: 242 MEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV 301
ME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG V
Sbjct: 363 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV 422
Query: 302 KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPP 361
KL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPP
Sbjct: 423 KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 482
Query: 362 YFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 421
Y NE PL+A+ +I N P L+N ++S + FL+R L D +R +A ELL+HPFL
Sbjct: 483 YLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL 542
Query: 422 AGPPASIVPLM 432
A P +S+ PL+
Sbjct: 543 AKPLSSLTPLI 553
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 341 bits (875), Expect = 7e-94
Identities = 199/506 (39%), Positives = 280/506 (55%), Gaps = 77/506 (15%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT------------------------------ 33
K K+R EIS PS+FEH +H GFD +FT
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQMC 122
Query: 34 ------GLPRQWQSLIE-------ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPS 80
G+P QW L++ E + P+ ++D + + S
Sbjct: 123 PGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKS 182
Query: 81 AGGL--AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP------------- 125
A G A P S+ ++S PP + + PP P
Sbjct: 183 AHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSV 242
Query: 126 ----AAPAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRS 166
A+PAVP PP + QR+ +++ E+ L+ +V GDP+
Sbjct: 243 VESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK 302
Query: 167 YLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVV 226
F KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V
Sbjct: 303 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 362
Query: 227 EMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 286
+SYLVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHR
Sbjct: 363 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHR 422
Query: 287 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIW 346
DIKSD+ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIW
Sbjct: 423 DIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIW 482
Query: 347 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 406
SLGIM IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +
Sbjct: 483 SLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 542
Query: 407 RATAAELLKHPFLAKAGPPASIVPLM 432
R +A ELL+HPFL A P +S+ PL+
Sbjct: 543 RGSAKELLQHPFLKLAKPLSSLTPLI 568
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 335 bits (859), Expect = 5e-92
Identities = 186/450 (41%), Positives = 267/450 (59%), Gaps = 38/450 (8%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDV 127
Query: 57 ACITSIQPGAPKGE----PHDVAPNGPSAGGLAIPQSSSSSSRPPTRAR------GAPSP 106
+ + + + A + S+ L + S + + PP A P
Sbjct: 128 LEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPP 187
Query: 107 GVLGPHASEPQ-------LAPPACTPAAPAVPGPPGPRS--------------PQREPQR 145
V+ P + + P TP P P Q++ +
Sbjct: 188 PVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPK 247
Query: 146 VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ 205
+S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L++Q
Sbjct: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
Query: 206 RRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 265
++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E QIA
Sbjct: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
Query: 266 AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT 325
AVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++VGT
Sbjct: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
Query: 326 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 385
PYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N P L+N
Sbjct: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
Query: 386 HKVSPSLKGFLDRLLVRDPAQRATAAELLK 415
K+S + FL+R L D +R +A ELL+
Sbjct: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 200 bits (509), Expect = 2e-51
Identities = 104/273 (38%), Positives = 163/273 (59%), Gaps = 4/273 (1%)
Query: 164 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 223
P D K+GEGS G V A + SG++VA+K++ + + + E+ IM+
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSP 80
Query: 224 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAAVCLAVLQALSVLHAQ 281
VV+ Y SY +LW+VME+ G+++DI+ + + E++IA + + L+ L LH
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 341
IHRDIK+ +ILL +G KL+DFG Q++ + +R +++GTP+WMAPE+I + Y
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 200
Query: 342 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 401
DIWSLGI IEM +G+PPY + P++A+ MI N PP + S F+ + LV
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 260
Query: 402 RDPAQRATAAELLKHPFLAKAGPPASIVPLMRQ 434
++P QRATA +LL+HPF+ A P + + L+ +
Sbjct: 261 KNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 199 bits (507), Expect = 3e-51
Identities = 101/261 (38%), Positives = 158/261 (60%), Gaps = 4/261 (1%)
Query: 164 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 223
P D K+GEGS G V A + +G++VA+K++ + + + E+ IM+
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--IIKEISIMQQCDSP 83
Query: 224 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAAVCLAVLQALSVLHAQ 281
+VV+ Y SY +LW+VME+ G+++DI+ + + E++IA + + L+ L LH
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 341
IHRDIK+ +ILL +G KL+DFG Q++ + +R +++GTP+WMAPE+I + Y
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203
Query: 342 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 401
DIWSLGI IEM +G+PPY + P++A+ MI N PP + S + F+ + LV
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263
Query: 402 RDPAQRATAAELLKHPFLAKA 422
+ P QRATA +LL+HPF+ A
Sbjct: 264 KSPEQRATATQLLQHPFVRSA 284
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 192 bits (488), Expect = 5e-49
Identities = 106/265 (40%), Positives = 166/265 (62%), Gaps = 6/265 (2%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 222
+P+ + +IG G+ G V A ++G+L A+K + L + ++ E+++M+D +H
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 223 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 281
N+V + SYL D+LW+ MEF GG+L DI T ++E QIA V LQ L LH++
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLP 338
G +HRDIK +ILLT +G VKL+DFG AQ++ + +RKS +GTPYWMAPE+ + +
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 339 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAM-KMIRDNL-PPRLKNLHKVSPSLKGFL 396
Y D+W++GI IE+ + +PP F+ P++A+ M + N PP+LK+ K S S F+
Sbjct: 191 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 250
Query: 397 DRLLVRDPAQRATAAELLKHPFLAK 421
L ++P +R TA +LL+HPF+ +
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQ 275
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 189 bits (481), Expect = 3e-48
Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 221
DP KIG+GS G V + K+VA+K +DL + + E + E+ ++
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 222 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 281
V + Y SYL +LW++ME+L GG+ D++ ++E QIA + +L+ L LH++
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 341
IHRDIK+ ++LL+ G VKL+DFG Q++ +R + VGTP+WMAPE+I + Y
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 342 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 401
+ DIWSLGI IE+ GEPP+ P+K + +I N PP L+ S LK F++ L
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256
Query: 402 RDPAQRATAAELLKHPFLAK 421
++P+ R TA ELLKH F+ +
Sbjct: 257 KEPSFRPTAKELLKHKFILR 276
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 189 bits (481), Expect = 3e-48
Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 221
DP KIG+GS G V + K+VA+K +DL + + E + E+ ++
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 222 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 281
V + Y SYL +LW++ME+L GG+ D++ ++E QIA + +L+ L LH++
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 150
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 341
IHRDIK+ ++LL+ G VKL+DFG Q++ +R + VGTP+WMAPE+I + Y
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210
Query: 342 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 401
+ DIWSLGI IE+ GEPP+ P+K + +I N PP L+ S LK F++ L
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 268
Query: 402 RDPAQRATAAELLKHPFLAK 421
++P+ R TA ELLKH F+ +
Sbjct: 269 KEPSFRPTAKELLKHKFILR 288
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 189 bits (480), Expect = 4e-48
Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 221
DP +IG+GS G V + ++VA+K +DL + + E + E+ ++
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 222 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 281
V + Y SYL G +LW++ME+L GG+ D++ +E QIA + +L+ L LH++
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 138
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 341
IHRDIK+ ++LL+ G VKL+DFG Q++ +R + VGTP+WMAPE+I + Y
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198
Query: 342 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 401
+ DIWSLGI IE+ GEPP + P++ + +I N PP L + + S K F+D L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL--VGDFTKSFKEFIDACLN 256
Query: 402 RDPAQRATAAELLKHPFLAK 421
+DP+ R TA ELLKH F+ K
Sbjct: 257 KDPSFRPTAKELLKHKFIVK 276
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 187 bits (475), Expect = 2e-47
Identities = 108/276 (39%), Positives = 160/276 (57%), Gaps = 10/276 (3%)
Query: 158 VVDPG----DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 213
VVDP DPR + D ++G G+ G V A + SG LVA+K + + L E
Sbjct: 3 VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE 62
Query: 214 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 272
++I++ +H N+V + SYL +LW+ MEF G+L DI T ++E QI+ VC VL
Sbjct: 63 ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL 122
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
Q L+ LH+Q IHRDIK +IL+ G V+L+DFG AQ+ + RR S +GTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 333 LIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHK 387
+ + + Y DIWSLGI IE+ + +PP F+ PL+ + ++ + PPRLK K
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
Query: 388 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 423
S + F+ L + P +R +A ++L H +++ G
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPG 278
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 187 bits (475), Expect = 2e-47
Identities = 108/276 (39%), Positives = 160/276 (57%), Gaps = 10/276 (3%)
Query: 158 VVDPG----DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 213
VVDP DPR + D ++G G+ G V A + SG LVA+K + + L E
Sbjct: 3 VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE 62
Query: 214 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 272
++I++ +H N+V + SYL +LW+ MEF G+L DI T ++E QI+ VC VL
Sbjct: 63 ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL 122
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
Q L+ LH+Q IHRDIK +IL+ G V+L+DFG AQ+ + RR S +GTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 333 LIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHK 387
+ + + Y DIWSLGI IE+ + +PP F+ PL+ + ++ + PPRLK K
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
Query: 388 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 423
S + F+ L + P +R +A ++L H +++ G
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPG 278
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 186 bits (473), Expect = 3e-47
Identities = 106/276 (38%), Positives = 161/276 (58%), Gaps = 6/276 (2%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 222
DPR + ++G G+ G V A + +L AVK + L L E+ I+R+ +H
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70
Query: 223 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 281
NVV SYL D LW+ MEF GG+L +I T + E QIA VC L+ L LH+Q
Sbjct: 71 PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQ 130
Query: 282 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLP 338
G IHRDIK ++LLT G VKL+DFG +++ V +R+S +GTPYWMAPE+ + +
Sbjct: 131 GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGG 190
Query: 339 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHKVSPSLKGFL 396
Y D+W+LGI IE+ + +PP F+ P++A+ ++ + PP+L++ + + + FL
Sbjct: 191 YNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFL 250
Query: 397 DRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 432
L ++P +R TA +LL+HPF + P A + L+
Sbjct: 251 KLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLL 286
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 186 bits (472), Expect = 4e-47
Identities = 104/272 (38%), Positives = 160/272 (58%), Gaps = 17/272 (6%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 222
DP + +G G+ G V +G+L A+K MD+ + E+ E+ +++ Y H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSH 78
Query: 223 E-NVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIAAVCLAVL 272
N+ Y +++ + D+LW+VMEF G++TD++ +T+ N EE IA +C +L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
+ LS LH VIHRDIK ++LLT + VKL DFG AQ+ + V RR + +GTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 333 LIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 387
+I+ Y + D+WSLGI IEM +G PP + P++A+ +I N PRLK+ K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 388 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 419
S + F++ LV++ +QR +L+KHPF+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 186 bits (472), Expect = 4e-47
Identities = 104/272 (38%), Positives = 160/272 (58%), Gaps = 17/272 (6%)
Query: 163 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 222
DP + +G G+ G V +G+L A+K MD+ + E+ E+ +++ Y H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSH 78
Query: 223 E-NVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIAAVCLAVL 272
N+ Y +++ + D+LW+VMEF G++TD++ +T+ N EE IA +C +L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 273 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 332
+ LS LH VIHRDIK ++LLT + VKL DFG AQ+ + V RR + +GTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 333 LIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 387
+I+ Y + D+WSLGI IEM +G PP + P++A+ +I N PRLK+ K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 388 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 419
S + F++ LV++ +QR +L+KHPF+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,962,302
Number of Sequences: 37866
Number of extensions: 1262509
Number of successful extensions: 18535
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 925
Number of HSP's successfully gapped in prelim test: 1150
Number of HSP's that attempted gapping in prelim test: 8801
Number of HSP's gapped (non-prelim): 6962
length of query: 438
length of database: 18,247,518
effective HSP length: 105
effective length of query: 333
effective length of database: 14,271,588
effective search space: 4752438804
effective search space used: 4752438804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.