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Search of human proteins with 61742777
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo
sapiens]
(1025 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 2056 0.0
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 2027 0.0
gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 810 0.0
gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 810 0.0
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 767 0.0
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 767 0.0
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 478 e-135
gi|132814467 glutamyl aminopeptidase [Homo sapiens] 477 e-134
gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 460 e-129
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 413 e-115
gi|194239713 laeverin [Homo sapiens] 373 e-103
gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 118 3e-26
gi|40316915 arginyl aminopeptidase [Homo sapiens] 92 2e-18
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 69 3e-11
gi|4507347 TBP-associated factor 2 [Homo sapiens] 41 0.005
gi|212286172 RNA polymerase I polypeptide B isoform 2 [Homo sapi... 36 0.21
gi|33469941 RNA polymerase I polypeptide B isoform 1 [Homo sapiens] 36 0.21
gi|89941479 hypothetical protein LOC148137 [Homo sapiens] 32 3.1
gi|51988900 XPG-complementing protein [Homo sapiens] 31 6.8
gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens] 31 6.8
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 30 8.9
>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
Length = 1025
Score = 2056 bits (5327), Expect = 0.0
Identities = 1025/1025 (100%), Positives = 1025/1025 (100%)
Query: 1 MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE 60
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
Sbjct: 1 MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE 60
Query: 61 HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV 120
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
Sbjct: 61 HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV 120
Query: 121 AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS 180
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
Sbjct: 121 AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS 180
Query: 181 LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH 240
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
Sbjct: 181 LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH 240
Query: 241 GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR 300
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
Sbjct: 241 GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR 300
Query: 301 SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA 360
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
Sbjct: 301 SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA 360
Query: 361 FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV 420
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
Sbjct: 361 FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV 420
Query: 421 AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW 480
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
Sbjct: 421 AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW 480
Query: 481 NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI 540
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
Sbjct: 481 NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI 540
Query: 541 EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT 600
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
Sbjct: 541 EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT 600
Query: 601 LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT 660
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
Sbjct: 601 LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT 660
Query: 661 EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP 720
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
Sbjct: 661 EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP 720
Query: 721 YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE 780
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
Sbjct: 721 YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE 780
Query: 781 KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM 840
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
Sbjct: 781 KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM 840
Query: 841 KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS 900
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
Sbjct: 841 KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS 900
Query: 901 EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS 960
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
Sbjct: 901 EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS 960
Query: 961 YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS 1020
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
Sbjct: 961 YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS 1020
Query: 1021 LTWWL 1025
LTWWL
Sbjct: 1021 LTWWL 1025
>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
Length = 1011
Score = 2027 bits (5251), Expect = 0.0
Identities = 1011/1011 (100%), Positives = 1011/1011 (100%)
Query: 15 MIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSA 74
MIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSA
Sbjct: 1 MIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSA 60
Query: 75 KLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRC 134
KLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRC
Sbjct: 61 KLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRC 120
Query: 135 TFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSV 194
TFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSV
Sbjct: 121 TFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSV 180
Query: 195 TISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAG 254
TISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAG
Sbjct: 181 TISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAG 240
Query: 255 HNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKAT 314
HNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKAT
Sbjct: 241 HNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKAT 300
Query: 315 FIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN 374
FIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN
Sbjct: 301 FIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN 360
Query: 375 GTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWG 434
GTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWG
Sbjct: 361 GTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWG 420
Query: 435 LLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFME 494
LLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFME
Sbjct: 421 LLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFME 480
Query: 495 YFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSS 554
YFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSS
Sbjct: 481 YFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSS 540
Query: 555 LLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQK 614
LLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQK
Sbjct: 541 LLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQK 600
Query: 615 GFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLL 674
GFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLL
Sbjct: 601 GFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLL 660
Query: 675 DKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINN 734
DKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINN
Sbjct: 661 DKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINN 720
Query: 735 IFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTR 794
IFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTR
Sbjct: 721 IFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTR 780
Query: 795 VFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQS 854
VFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQS
Sbjct: 781 VFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQS 840
Query: 855 LPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSL 914
LPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSL
Sbjct: 841 LPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSL 900
Query: 915 NGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLF 974
NGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLF
Sbjct: 901 NGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLF 960
Query: 975 STKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025
STKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
Sbjct: 961 STKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1011
>gi|94818891 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform b [Homo sapiens]
Length = 941
Score = 810 bits (2093), Expect = 0.0
Identities = 418/903 (46%), Positives = 575/903 (63%), Gaps = 38/903 (4%)
Query: 153 PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHST 212
P ++G FPW +IRLP V+P+ Y+L +H NLT++TF G+ + + A Q T IILHS
Sbjct: 39 PKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSH 98
Query: 213 GHNISRVTFMSAVSSQ--EKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSS 270
ISR T + E+ ++LE+ QIA++APE LL G YT+ I Y+ N+S +
Sbjct: 99 HLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSET 158
Query: 271 YYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSN 330
++GFY +Y + E + A+TQFEP AAR AFPCFDEPAFKA+F IKI R+ ++ A+SN
Sbjct: 159 FHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISN 218
Query: 331 MPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKIGQ 389
MP SV + +GL++D F +VKMSTYLVAFI+ + +++S+ +G VS+YAVP+KI Q
Sbjct: 219 MPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQ 278
Query: 390 VHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNT 449
YAL+ V LLEF+++YF I YPL K DL AIPDF++GAMENWGL T+RE LL+D+
Sbjct: 279 ADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEK 338
Query: 450 SSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYE 509
SS + + +T +AHELAHQWFGNLVTM+WWNDLWLNEGFA FME+ S+ EL +
Sbjct: 339 SSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGD 398
Query: 510 DFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQ 569
F F M+ D+LNSSHP+S+ V++ QI EMFD +SY KG+ +L ML+ YLS D F+
Sbjct: 399 YFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFK 458
Query: 570 HAVVLYLHNHSYASIQSDDLWDSFNEVT-------------------------NQTLDVK 604
+V YL HSY + +++DLWDS + + +DVK
Sbjct: 459 SGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVK 518
Query: 605 RMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRN 664
MM TWTLQKGFPL+T+ +G+ + ++QE + MK DT YLWH+PL+++T
Sbjct: 519 TMMNTWTLQKGFPLITITVRGRNVHMKQEHY---MKGSDGAPDTGYLWHVPLTFIT---- 571
Query: 665 YSKYQSVS--LLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYV 722
SK V LL K+ V+ L EEV W+K N+ MNGYYIVHY DD W++L LK
Sbjct: 572 -SKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTA 630
Query: 723 LSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKL 782
+S DRA+LINN F+L +GK+ +++A DL YL +E P+ + L + +Y L+EK
Sbjct: 631 VSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKR 690
Query: 783 GYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKL 842
++ ++ + +LL++ I +QTWTDEG+ S R LRS LL AC HN C A
Sbjct: 691 DMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGY 750
Query: 843 FDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSED 902
F W SNG SLP DV VF VGA++ +GW FL KY S EK++I AL +++
Sbjct: 751 FRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQN 810
Query: 903 VRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYT 962
KL WL+ S GD +TQ+ I+ +GR+ G+ LAW F+++NWNKLVQKF LGS +
Sbjct: 811 KEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSS 870
Query: 963 IQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLT 1022
I ++V G+T FST+T L EV+ FF + E +LRCVQ+ +E I+ NI WM+KN +
Sbjct: 871 IAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIR 930
Query: 1023 WWL 1025
WL
Sbjct: 931 VWL 933
>gi|94818901 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform a [Homo sapiens]
Length = 948
Score = 810 bits (2093), Expect = 0.0
Identities = 418/903 (46%), Positives = 575/903 (63%), Gaps = 38/903 (4%)
Query: 153 PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHST 212
P ++G FPW +IRLP V+P+ Y+L +H NLT++TF G+ + + A Q T IILHS
Sbjct: 39 PKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSH 98
Query: 213 GHNISRVTFMSAVSSQ--EKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSS 270
ISR T + E+ ++LE+ QIA++APE LL G YT+ I Y+ N+S +
Sbjct: 99 HLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSET 158
Query: 271 YYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSN 330
++GFY +Y + E + A+TQFEP AAR AFPCFDEPAFKA+F IKI R+ ++ A+SN
Sbjct: 159 FHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISN 218
Query: 331 MPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKIGQ 389
MP SV + +GL++D F +VKMSTYLVAFI+ + +++S+ +G VS+YAVP+KI Q
Sbjct: 219 MPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQ 278
Query: 390 VHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNT 449
YAL+ V LLEF+++YF I YPL K DL AIPDF++GAMENWGL T+RE LL+D+
Sbjct: 279 ADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEK 338
Query: 450 SSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYE 509
SS + + +T +AHELAHQWFGNLVTM+WWNDLWLNEGFA FME+ S+ EL +
Sbjct: 339 SSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGD 398
Query: 510 DFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQ 569
F F M+ D+LNSSHP+S+ V++ QI EMFD +SY KG+ +L ML+ YLS D F+
Sbjct: 399 YFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFK 458
Query: 570 HAVVLYLHNHSYASIQSDDLWDSFNEVT-------------------------NQTLDVK 604
+V YL HSY + +++DLWDS + + +DVK
Sbjct: 459 SGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVK 518
Query: 605 RMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRN 664
MM TWTLQKGFPL+T+ +G+ + ++QE + MK DT YLWH+PL+++T
Sbjct: 519 TMMNTWTLQKGFPLITITVRGRNVHMKQEHY---MKGSDGAPDTGYLWHVPLTFIT---- 571
Query: 665 YSKYQSVS--LLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYV 722
SK V LL K+ V+ L EEV W+K N+ MNGYYIVHY DD W++L LK
Sbjct: 572 -SKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTA 630
Query: 723 LSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKL 782
+S DRA+LINN F+L +GK+ +++A DL YL +E P+ + L + +Y L+EK
Sbjct: 631 VSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKR 690
Query: 783 GYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKL 842
++ ++ + +LL++ I +QTWTDEG+ S R LRS LL AC HN C A
Sbjct: 691 DMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGY 750
Query: 843 FDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSED 902
F W SNG SLP DV VF VGA++ +GW FL KY S EK++I AL +++
Sbjct: 751 FRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQN 810
Query: 903 VRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYT 962
KL WL+ S GD +TQ+ I+ +GR+ G+ LAW F+++NWNKLVQKF LGS +
Sbjct: 811 KEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSS 870
Query: 963 IQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLT 1022
I ++V G+T FST+T L EV+ FF + E +LRCVQ+ +E I+ NI WM+KN +
Sbjct: 871 IAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIR 930
Query: 1023 WWL 1025
WL
Sbjct: 931 VWL 933
>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 767 bits (1980), Expect = 0.0
Identities = 401/906 (44%), Positives = 561/906 (61%), Gaps = 36/906 (3%)
Query: 153 PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHST 212
P ATNG+ FPW ++RLP+ V+PL Y+L +HPNLTS+ F S I V T IILHS
Sbjct: 54 PVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSK 113
Query: 213 GHNISRVTFMSAVSSQE----KQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANIS 268
I+ T S S+ K+ ++L Y H QIA++ PE L Y + +++ A +
Sbjct: 114 DLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
Query: 269 SSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTAL 328
+ GFY +Y E + A T FEP AR AFPCFDEP FKA F IKI R+ ++ AL
Sbjct: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
Query: 329 SNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAVPEKI 387
SNMPK ++ L+ GL++D F +VKMSTYLVA+IV + +LS + G VSIYA P+K
Sbjct: 234 SNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKR 293
Query: 388 GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDS 447
Q HYAL+ ++KLL+F++ YF+I YPL KLDL+AIPDF GAMENWGL+T+RE +LL+D
Sbjct: 294 NQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDP 353
Query: 448 NTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSS 507
TSS +D+ VT++IAHELAHQWFGNLVTM+WWND+WL EGFA +ME ++ + EL
Sbjct: 354 KTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQF 413
Query: 508 YEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDV 567
+ FL+ F+ + KDSLNSS PIS ++ QI+EMFD +SY KG+ +L MLK +L E+
Sbjct: 414 DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEK 473
Query: 568 FQHAVVLYLHNHSYASIQSDDLWDSFN------------------EVTNQTL-------D 602
FQ ++ YL SY + ++DDLW S + ++T+ L +
Sbjct: 474 FQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAE 533
Query: 603 VKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNM---KPEIQPSDTSYLWHIPLSYV 659
VK MM TWTLQKG PL+ V++ G L +QQERF + PE + YLWHIPL+Y
Sbjct: 534 VKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYS 593
Query: 660 TEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKIN 719
T N +L K+ ++L E+ WVK N++ NGYYIVHY W+ LI QL N
Sbjct: 594 TSSSNVIHRH---ILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650
Query: 720 PYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLL 779
+L KDR LI+++F+L G G++ L +A D+ YL +E + + E L + Y+++
Sbjct: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMM 710
Query: 780 EKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTA 839
++ D++ L + + + I +Q+W+D+G+ R LRSALL+ AC N C A
Sbjct: 711 DRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKA 770
Query: 840 MKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALAS 899
+LF WM S+G ++PTDV+ V+ VGA+T GW++LL +Y S AE+NKIL AL++
Sbjct: 771 AELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALST 830
Query: 900 SEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLG 959
S+ KL L++ + G +TQ L+ ++ + R G LAWDFV+ENW L++KF LG
Sbjct: 831 SKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLG 890
Query: 960 SYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLK 1019
SY I+ I++G+T FS+K L EV+ FFE+ L Q LE I NI+W+EKNL
Sbjct: 891 SYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLP 950
Query: 1020 SLTWWL 1025
+L WL
Sbjct: 951 TLRTWL 956
>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 767 bits (1980), Expect = 0.0
Identities = 401/906 (44%), Positives = 561/906 (61%), Gaps = 36/906 (3%)
Query: 153 PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHST 212
P ATNG+ FPW ++RLP+ V+PL Y+L +HPNLTS+ F S I V T IILHS
Sbjct: 54 PVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSK 113
Query: 213 GHNISRVTFMSAVSSQE----KQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANIS 268
I+ T S S+ K+ ++L Y H QIA++ PE L Y + +++ A +
Sbjct: 114 DLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
Query: 269 SSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTAL 328
+ GFY +Y E + A T FEP AR AFPCFDEP FKA F IKI R+ ++ AL
Sbjct: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
Query: 329 SNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAVPEKI 387
SNMPK ++ L+ GL++D F +VKMSTYLVA+IV + +LS + G VSIYA P+K
Sbjct: 234 SNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKR 293
Query: 388 GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDS 447
Q HYAL+ ++KLL+F++ YF+I YPL KLDL+AIPDF GAMENWGL+T+RE +LL+D
Sbjct: 294 NQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDP 353
Query: 448 NTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSS 507
TSS +D+ VT++IAHELAHQWFGNLVTM+WWND+WL EGFA +ME ++ + EL
Sbjct: 354 KTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQF 413
Query: 508 YEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDV 567
+ FL+ F+ + KDSLNSS PIS ++ QI+EMFD +SY KG+ +L MLK +L E+
Sbjct: 414 DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEK 473
Query: 568 FQHAVVLYLHNHSYASIQSDDLWDSFN------------------EVTNQTL-------D 602
FQ ++ YL SY + ++DDLW S + ++T+ L +
Sbjct: 474 FQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAE 533
Query: 603 VKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNM---KPEIQPSDTSYLWHIPLSYV 659
VK MM TWTLQKG PL+ V++ G L +QQERF + PE + YLWHIPL+Y
Sbjct: 534 VKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYS 593
Query: 660 TEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKIN 719
T N +L K+ ++L E+ WVK N++ NGYYIVHY W+ LI QL N
Sbjct: 594 TSSSNVIHRH---ILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650
Query: 720 PYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLL 779
+L KDR LI+++F+L G G++ L +A D+ YL +E + + E L + Y+++
Sbjct: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMM 710
Query: 780 EKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTA 839
++ D++ L + + + I +Q+W+D+G+ R LRSALL+ AC N C A
Sbjct: 711 DRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKA 770
Query: 840 MKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALAS 899
+LF WM S+G ++PTDV+ V+ VGA+T GW++LL +Y S AE+NKIL AL++
Sbjct: 771 AELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALST 830
Query: 900 SEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLG 959
S+ KL L++ + G +TQ L+ ++ + R G LAWDFV+ENW L++KF LG
Sbjct: 831 SKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLG 890
Query: 960 SYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLK 1019
SY I+ I++G+T FS+K L EV+ FFE+ L Q LE I NI+W+EKNL
Sbjct: 891 SYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLP 950
Query: 1020 SLTWWL 1025
+L WL
Sbjct: 951 TLRTWL 956
>gi|157266300 membrane alanine aminopeptidase precursor [Homo sapiens]
Length = 967
Score = 478 bits (1231), Expect = e-135
Identities = 305/902 (33%), Positives = 470/902 (52%), Gaps = 51/902 (5%)
Query: 163 WAQIRLPTAVVPLRYELSLHPNLTS-----MTFRGSVTISVQALQVTWNIILHSTGHNIS 217
W + RLP + P Y ++L P LT F+GS T+ + T II+HS N +
Sbjct: 71 WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYT 130
Query: 218 -----RVTFMSAVSSQEKQAEILEYAYHGQIAIVAPE-ALLAGHNYTLKIEYSANISSSY 271
RV SQ + E + +V + +L+ Y + E+ ++
Sbjct: 131 LSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 190
Query: 272 YGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNM 331
GFY Y E N +K A TQ + AR +FPCFDEPA KA F I +I + TALSNM
Sbjct: 191 AGFYRSEYM-EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNM 249
Query: 332 -PKKSSVVL--DDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI 387
PK S L D EF + KMSTYL+AFIV E + + NG L+ I+A P I
Sbjct: 250 LPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAI 309
Query: 388 GQVH--YALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLY 445
H YAL T +L FF +++ YPL K D + +PDF AGAMENWGL+T+RE +LL+
Sbjct: 310 AAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLF 369
Query: 446 DSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKI---- 501
D +SS ++++ V +IAHELAHQWFGNLVT++WWNDLWLNEGFA+++EY +
Sbjct: 370 DPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTW 429
Query: 502 -FKELSSYEDFLDARFKTMKKDSLNSSHPIS---SSVQSSEQIEEMFDSLSYFKGSSLLL 557
K+L D ++ M D+L SSHP+S S + + QI E+FD++SY KG+S+L
Sbjct: 430 NLKDLMVLNDV----YRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLR 485
Query: 558 MLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQ-----TLDVKRMMKTWTL 612
ML ++LSEDVF+ + YLH +Y + +LWD E N V+ +M WTL
Sbjct: 486 MLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTL 545
Query: 613 QKGFPLVTVQKKGKELFIQQERFFLNMKPEI-QPSDTSYLWHIPLSYVTEGRNYSKYQSV 671
Q GFP++TV L QE F L+ + +PS+ +Y+W +P++ + +GR Y +
Sbjct: 546 QMGFPVITVDTSTGTL--SQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLI 603
Query: 672 SLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANL 731
+ + + T WV +N+N+ GYY V+Y +++W + QL+ + + +RA +
Sbjct: 604 DV--RAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQI 661
Query: 732 INNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD---LIYNLLEKLGYM-DL 787
IN+ F LA KVP+ A + +L E P AL L+++ E G M +
Sbjct: 662 INDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNY 721
Query: 788 ASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA-LLEFACTHNLGNCSTTAMKLFDDW 846
+ VT +F +N W + M + + AC++ + C LF W
Sbjct: 722 LKKQVTPLFIHFRN--NTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQW 779
Query: 847 MASNGTQSLPTDVMTTVF--KVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVR 904
M + + ++ +TV+ + ++ W F ++ + E +K+ ALA S+++
Sbjct: 780 MENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELW 839
Query: 905 KLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQ 964
L + +LN D R Q + I ++ + G L WDFV+ NW KL + GS++
Sbjct: 840 ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS 899
Query: 965 NIVAGSTYLFSTKTHLSEVQAFFENQSEATF--RLRCVQEALEVIQLNIQWMEKNLKSLT 1022
N++ T FST+ L +++ F ++ E F R +++ALE + NI+W+++N + +
Sbjct: 900 NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL 959
Query: 1023 WW 1024
W
Sbjct: 960 QW 961
>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
Length = 957
Score = 477 bits (1227), Expect = e-134
Identities = 299/953 (31%), Positives = 485/953 (50%), Gaps = 50/953 (5%)
Query: 105 VPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEG--------CHKKNQSIGLIQPFAT 156
+ + ++CA V+ V + V + + L C + +G H + + P A
Sbjct: 14 IQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQ 73
Query: 157 NGKLFP--------WAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNII 208
+ + P W RLP V P+ Y+L + P L T+ G+V+IS+ T +
Sbjct: 74 DQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLW 133
Query: 209 LHSTGHNISRVTFMSAVSSQEKQAE-ILEYAYHGQIAIVAPEALLAGHN---YTLKIEYS 264
LH I+R+ + S + Q EY + + A E L Y L +E++
Sbjct: 134 LHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFA 193
Query: 265 ANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQ 324
++ S GFY +YT E+ + K AT EP AR +FPCFDEP KAT+ I I ++
Sbjct: 194 GWLNGSLVGFYRTTYT-ENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKE 252
Query: 325 YTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAV 383
Y ALSNMP +DD + F +SV MSTYLV F V + ++ + N G ++IY
Sbjct: 253 YGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQ 312
Query: 384 PEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETL 443
PE+ YA T + ++F+ YF + Y L KLD +AIPDF GAMENWGL+T+RE L
Sbjct: 313 PEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNL 372
Query: 444 LYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK 503
LYD S+ ++++ V ++AHEL HQWFGN+VTM WW DLWLNEGFA+F E+ +
Sbjct: 373 LYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAET 432
Query: 504 ELSSYED-FLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTY 562
+ + L+ + DSL SSHPI +V + ++I +FD +SY KGSS+L ML+ +
Sbjct: 433 DWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDW 492
Query: 563 LSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQ 622
+ + FQ +YL + + + ++ D W + E + L VK +M TWT Q G+P++ V
Sbjct: 493 IKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASR--LPVKEVMDTWTRQMGYPVLNVN 550
Query: 623 KKGKELFIQQERFFLNMK--PEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGV 680
I Q+RF L+ + P PSD Y W+IP+ + + N + + +K+
Sbjct: 551 GVKN---ITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTED--NITSSVLFNRSEKEGIT 605
Query: 681 INLTEEV--LWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFEL 738
+N + ++K+N + G+Y V+Y W+++ L +N S DRA+LI++ F L
Sbjct: 606 LNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFAL 665
Query: 739 AGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKL 798
A + K A +L YL E + P + I ++ E L + +
Sbjct: 666 ARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFED------DKELYPMIEEY 719
Query: 799 LQNQIQ----QQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQS 854
Q Q++ W D G + LRS++L FAC A LF+ W+ NGT S
Sbjct: 720 FQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWL--NGTVS 777
Query: 855 LPTDVMTTVFKVGAK---TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMK 911
LP ++ V++ G + + W++ L +Y EK K+L LAS ++V L +
Sbjct: 778 LPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLD 837
Query: 912 SSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGST 971
+ + +TQ + +IR + + G +AW++++ NW+ LV ++ L + + IV
Sbjct: 838 LLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IA 896
Query: 972 YLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWW 1024
F+T+ L ++++FF +A + ++ LE ++ NI+W++++ ++ W
Sbjct: 897 EPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
Length = 1024
Score = 460 bits (1184), Expect = e-129
Identities = 284/888 (31%), Positives = 449/888 (50%), Gaps = 28/888 (3%)
Query: 162 PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 221
PW Q+RL + PL Y L L + + TF G V + + T ++LH++ + +V
Sbjct: 135 PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194
Query: 222 MS-AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYT 280
A Y + +V L A NY LKI Y+A I + GF+ SY
Sbjct: 195 AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYV 254
Query: 281 DESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLD 340
E+++ TQF P AR AFPCFDEP +KATF I I Y +LSNMP ++SV +
Sbjct: 255 LHG-ERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 313
Query: 341 DGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI--GQVHYALETT 397
DG V D FS++ MSTY +A+ + +G +V +YA P+ I G YAL T
Sbjct: 314 DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHIT 373
Query: 398 VKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKL 457
+L+EF+++YF++ Y L KLDL+A+P AMENWGL F E+ +L D + SS++
Sbjct: 374 KRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD 433
Query: 458 VTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK--ELSSYEDFLDAR 515
VT +I HE+ HQWFG+LVT WW D+WL EGFA + E+ + ++ + D
Sbjct: 434 VTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVL 493
Query: 516 FKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLY 575
+ M D L SSHP+S V + I+ +FD ++Y KG++L+ ML ++ VFQ + Y
Sbjct: 494 HEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDY 553
Query: 576 LHNHSYASIQSDDLWDSFNEVTNQT---LDVKRMMKTWTLQKGFPLVTV---QKKGKELF 629
L H Y + +DLW++ +E + ++++ +M WTLQ G+P++T+ +
Sbjct: 554 LTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRII 613
Query: 630 IQQERFFLNMKPE---IQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLT-- 684
I Q+ F ++ + ++ + SYLW IPL+ V R++ +++ + KS +T
Sbjct: 614 ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYL 673
Query: 685 EEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKV 744
++ W+ NIN GY+ V+Y +W LI QL N VLS +RA LI++ F LA G +
Sbjct: 674 DKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYL 733
Query: 745 PLKRAFDLINYLGNENHTAP---ITEALFQTDLIYNLLEKLGYMD--LASRLVTRVFKLL 799
P ++I YL E P + AL+ D + + +E + + ++ T KL
Sbjct: 734 PQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLG 793
Query: 800 QNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDV 859
+ + + ELR ++ AC+ +C A L DW++SN + +P +V
Sbjct: 794 WPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNR-IPLNV 852
Query: 860 MTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGD 917
V+ G + W F+ K+ S + +EK +LEAL S+D L L+ SLN +
Sbjct: 853 RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSE 912
Query: 918 NFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTK 977
Q +I V R+ G LAW F ++ W L ++ + +++G T +T+
Sbjct: 913 VVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTE 972
Query: 978 THLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025
L E++ F +N A+E ++ N++W L WL
Sbjct: 973 GELKELKNFMKNYDGVA--AASFSRAVETVEANVRWKMLYQDELFQWL 1018
>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
Length = 919
Score = 413 bits (1061), Expect = e-115
Identities = 277/880 (31%), Positives = 439/880 (49%), Gaps = 44/880 (5%)
Query: 167 RLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVS 226
RLP V P+ Y L L P+L TF G + + Q Q T I++ N + + ++A
Sbjct: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVM-----NCADIDIITASY 107
Query: 227 SQEKQAEILEYAYHGQ-----IAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTD 281
+ E EI ++ Q + + P L G TLKI++ ++ GFY YT
Sbjct: 108 APEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRSKYTT 166
Query: 282 ESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMP--KKSSVVL 339
S E +Y A TQFE AR AFPC+DEPA KATF I ++ + ALSNM +
Sbjct: 167 PSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPD 226
Query: 340 DDGLVQDEFSESVKMSTYLVAFIVGEMKNL-SQDVNGTLVSIYAVPEKIGQVHYALETTV 398
D+ LV+ +F+ + MSTYLVAF+VGE + ++ +G V +Y K Q +ALE
Sbjct: 227 DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAA 286
Query: 399 KLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLV 458
K L F+++YF + YPL K+DL+AI DF AGAMENWGL+T+RE LL D S + R+ V
Sbjct: 287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWV 346
Query: 459 TKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARF-K 517
++ HELAHQWFGNLVTM+WW LWLNEGFA+++EY ++ F E + F+ A + +
Sbjct: 347 ALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTR 406
Query: 518 TMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLH 577
+ D+L++SHPI SV +++E+FD++SY KG+S++ ML Y+ + F+ + +YL
Sbjct: 407 AQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLT 466
Query: 578 NHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKE----LFIQQE 633
+ ++DLW+S + + + +M TWT Q GFPL+ V+ + E L + Q+
Sbjct: 467 KFQQKNAATEDLWESLENASGK--PIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQK 524
Query: 634 RFFLNMKPEIQPSDTSYLWHIPLSYVT-EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKV 692
+F + W +P++ T E N +K + + + + V+ + WVK+
Sbjct: 525 KFCAGGS---YVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKL 581
Query: 693 NINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDL 752
N+ G+Y Y+ E+L+ I L DR L N++F LA G + +
Sbjct: 582 NLGTVGFYRTQYSSAMLESLLP--GIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKV 639
Query: 753 INYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEG 812
+ NE + ++ ++ LL + + V VF + ++ EG
Sbjct: 640 MEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEG 699
Query: 813 TPSMRELRSALLEFACTHNLGNCS-----TTAMKLFDDWMASNGTQSLPTDVMTTVFKVG 867
ALL LG A + F D + G Q L D+ + V+
Sbjct: 700 H------LDALLRGLVLGKLGKAGHKATLEEARRRFKDHV--EGKQILSADLRSPVYLTV 751
Query: 868 AKTDKGWS--FLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLS 925
K G + +L + + EKN+I L ++ + ++ +L+ + +S
Sbjct: 752 LKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVS 811
Query: 926 FIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQA 985
I G G AW F+K+NW +L ++ G + I ++ S F+ EV+A
Sbjct: 812 VIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKA 870
Query: 986 FFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025
FFE+ A R +Q+ E I LN W++++ +S+ +L
Sbjct: 871 FFESH-PAPSAERTIQQCCENILLNAAWLKRDAESIHQYL 909
>gi|194239713 laeverin [Homo sapiens]
Length = 990
Score = 373 bits (957), Expect = e-103
Identities = 270/911 (29%), Positives = 449/911 (49%), Gaps = 79/911 (8%)
Query: 162 PWAQIRLPTAVVPLRYELSLHPNLT-------SMTFRGSVTISVQALQVTWNIILHSTGH 214
PW Q+RLP +VPL Y+L L P L S+ F G V I+V+ T ++LHS
Sbjct: 92 PWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQ 151
Query: 215 NISRVTFMSAVSSQEKQAEI-----------LEYAYHGQIAIVAPEALLAGHNYTLKIEY 263
+ R +S A + L+ Y + + E L G +Y L++ +
Sbjct: 152 DCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEY---MVLELSEPLKPGSSYELQLSF 208
Query: 264 SANISSSYY-GFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRD 322
S + G + YTD+ E++ A+Q EP AR FPCFDEPA KATF I +I
Sbjct: 209 SGLVKEDLREGLFLNVYTDQG-ERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHH 267
Query: 323 EQYTALSNMPKKSSVVLDD----GLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLV 378
Y ALSNMPK +D FS + M TYLVAF++ + ++++ G +
Sbjct: 268 PSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEI 327
Query: 379 SIYAVPEKI--GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLL 436
I+A + I G +AL T + F ++ F I Y L K D++A+P F+ AMENWGL+
Sbjct: 328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387
Query: 437 TFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYF 496
F E LL + + L++ +++HE+ HQWFGNLVTM WWN++WLNEGFA++ E+
Sbjct: 388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFE 447
Query: 497 SLEKIFKELSSYEDFL-DARFKTMKKDSLNSSHPISSSVQS--SEQIEEMFDSLSYFKGS 553
+ +L E F + +++D + ++ V++ + +I+E+FD +Y KG+
Sbjct: 448 VINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGA 507
Query: 554 SLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDV------KRMM 607
S+ ML +L+E +F A+ YL SY++ + DDLW F + V K +M
Sbjct: 508 SMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIM 567
Query: 608 KTWTLQKGFPLVTVQKKGKELFIQQERFFL-NMKPE--IQPSDTSYLWHIPLSYVTEGRN 664
+WT Q GFP++T+ + +QE F+L N+K + +DT W +P+ ++ G
Sbjct: 568 DSWTHQSGFPVITLNVSTGVM--KQEPFYLENIKNRTLLTSNDT---WIVPILWIKNGTT 622
Query: 665 YSKYQSVSLLDKKSGVINLTE----EVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP 720
Q + LD+ S V + + WV +N+NM GYY V+Y W+ L QL+ +P
Sbjct: 623 ----QPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDP 678
Query: 721 YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE 780
+ R LI++ F L+ + ++ A +L YL E+ + + + +L+
Sbjct: 679 KAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEII-VWHTVLVNLVTRDLVS 737
Query: 781 KLGYMDLASRLVTRVFKLLQNQIQQ--QTWTDEGTPSMRELRSALLEF------ACTHNL 832
++ D+ S L + K L N I T E ++++ AL+ AC L
Sbjct: 738 EVNIYDIYSLLKRYLLKRL-NLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGL 796
Query: 833 GNCSTTAMKLFDDWMASNGTQSLPTDVMTTV--FKVGAKTDKGWSFLLGKYISIGSEAEK 890
+C + +LF W+ + +P + V + + +DK W LL Y + ++ EK
Sbjct: 797 EDCLQLSKELFAKWV-DHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEK 855
Query: 891 NKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWN 950
++ A++ S+D L M+ +++ F + + + II V G +A DF+ NW
Sbjct: 856 IQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETN-IIEVVASSEVGRYVAKDFLVNNWQ 914
Query: 951 KLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLN 1010
+ +++ G+ ++ N++ +T + E+Q FF N E R+R + N
Sbjct: 915 AVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR--------VHAN 964
Query: 1011 IQWME-KNLKS 1020
+Q ++ +NLK+
Sbjct: 965 LQTIKNENLKN 975
>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
Length = 611
Score = 118 bits (295), Expect = 3e-26
Identities = 116/456 (25%), Positives = 200/456 (43%), Gaps = 51/456 (11%)
Query: 184 NLTSMTFRGSVTISVQALQVTW-NIILHSTGHNISRVTFMSAVSSQEKQAEILE-YAYHG 241
+ T T G+ ++VQ+ + +++L + I +V ++ QE + + E +Y G
Sbjct: 29 DFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVV----INGQEVKYALGERQSYKG 84
Query: 242 Q-IAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR 300
+ I P AL ++I + + SS + T S ++ + +Q + + R
Sbjct: 85 SPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQT--SGKEHPYLFSQCQAIHCR 142
Query: 301 SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQD---------EFSES 351
+ PC D P+ K T+ ++ ++ AL + + DG D +F +
Sbjct: 143 AILPCQDTPSVKLTYTAEVSVPKELVALMS-------AIRDGETPDPEDPSRKIYKFIQK 195
Query: 352 VKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQN----Y 407
V + YL+A +VG ++ S+ + G +++ E++ + Y T +L+ ++ Y
Sbjct: 196 VPIPCYLIALVVGALE--SRQI-GPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPY 252
Query: 408 FEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELA 467
QY L LV P F G MEN LTF TLL A K ++ +IAHE++
Sbjct: 253 VWGQYDL----LVLPPSFPYGGMEN-PCLTFVTPTLL--------AGDKSLSNVIAHEIS 299
Query: 468 HQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKK-DSLNS 526
H W GNLVT K W+ WLNEG ++E ++F E + + L + +
Sbjct: 300 HSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGE 359
Query: 527 SHPISSSVQSSEQIEE--MFDSLSYFKGSSLLLMLKTYL-SEDVFQHAVVLYLHNHSYAS 583
+HP + V I+ + S+ Y KG +LL L+ L ++F + Y+ SY S
Sbjct: 360 THPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKS 419
Query: 584 IQSDDLWDSFNEVTNQTLDVKRMM--KTWTLQKGFP 617
I +DD D +DV + W G P
Sbjct: 420 ITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLP 455
>gi|40316915 arginyl aminopeptidase [Homo sapiens]
Length = 650
Score = 92.0 bits (227), Expect = 2e-18
Identities = 109/436 (25%), Positives = 177/436 (40%), Gaps = 49/436 (11%)
Query: 183 PNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSA----VSSQEKQAEILEY- 237
P S G+ + ++ L+ L H VT + S+E AE + +
Sbjct: 52 PGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFY 111
Query: 238 ----AYHGQIAIVA-PEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAAT 292
+++GQ V+ P+ A + + Y G + + +KK F T
Sbjct: 112 TQPFSHYGQALCVSFPQPCRAAERLQVLLTYRVGEGP---GVCWLAPEQTAGKKKPFVYT 168
Query: 293 QFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESV 352
Q + + R+ FPCFD PA K + I + +TA+ + +S G + F
Sbjct: 169 QGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMS----ASTWEKRGPNKFFFQMCQ 224
Query: 353 KMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVP--------EKIGQVHYALETTVKLLEFF 404
+ +YL+A +G++ +S +V G ++A P E G + L T KL F
Sbjct: 225 PIPSYLIALAIGDL--VSAEV-GPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKL---F 278
Query: 405 QNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAH 464
Y +Y L L P F G MEN LTF LL + S+AD +I H
Sbjct: 279 GPYVWGRYDL----LFMPPSFPFGGMEN-PCLTFVTPCLL--AGDRSLAD------VIIH 325
Query: 465 ELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIF-KELSSYEDFLDARFKTMKKDS 523
E++H WFGNLVT W + WLNEGF + + +F + E D
Sbjct: 326 EISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDI 385
Query: 524 LNSSHPISS---SVQSSEQIEEMFDSLSYFKGSSLLLMLKTYL-SEDVFQHAVVLYLHNH 579
+P++ ++ ++ ++ Y KG + L + +D F + Y+H
Sbjct: 386 TGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEF 445
Query: 580 SYASIQSDDLWDSFNE 595
+ SI +DD D + E
Sbjct: 446 KFRSILADDFLDFYLE 461
>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
sapiens]
Length = 494
Score = 68.6 bits (166), Expect = 3e-11
Identities = 76/284 (26%), Positives = 120/284 (42%), Gaps = 44/284 (15%)
Query: 357 YLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKK 416
YLVA + G++K D+ G ++A P + L V+ Y +
Sbjct: 26 YLVALVAGDLK--PADI-GPRSRVWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGR 82
Query: 417 LDLVAIP-DFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLV 475
D+V +P F AMEN LTF ++L +D LV +I HE+AH WFGN V
Sbjct: 83 YDIVFLPPSFPIVAMEN-PCLTFIISSILE-------SDEFLVIDVI-HEVAHSWFGNAV 133
Query: 476 TMKWWNDLWLNEGFATFME-----------YFSLEKIFKELSSYEDFLDARFKTMKKDSL 524
T W ++WL+EG AT+ + + LE F+ LDA + MK L
Sbjct: 134 TNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFR--------LDALHRQMK--LL 183
Query: 525 NSSHPISS---SVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSE-DVFQHAVVLYLHNHS 580
P+S ++ + + +Y KG + L + F + Y+ +
Sbjct: 184 GEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYK 243
Query: 581 YASIQSDDLWDS----FNEVTNQTLDVKRMM--KTWTLQKGFPL 618
+ S+ + DL DS F E+ Q++D + + + W G PL
Sbjct: 244 FTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPL 287
>gi|4507347 TBP-associated factor 2 [Homo sapiens]
Length = 1199
Score = 41.2 bits (95), Expect = 0.005
Identities = 38/206 (18%), Positives = 84/206 (40%), Gaps = 5/206 (2%)
Query: 298 AARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQD-EFSESVKMST 356
+ R FPC D + T+ ++ D A+SN +V D + + ++ +
Sbjct: 185 STRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAA 244
Query: 357 YLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKK 416
++ +G + L D V+ + +P+ + + + ++ EF++ +YP
Sbjct: 245 SNISLAIGPFEILV-DPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSC 303
Query: 417 LDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVT 476
V I + + F L + + + L + +A LA Q+FG ++
Sbjct: 304 FKTVFIDEAYVEVAAYASMSIFSTNLL---HSAMIIDETPLTRRCLAQSLAQQFFGCFIS 360
Query: 477 MKWWNDLWLNEGFATFMEYFSLEKIF 502
W+D W+ +G + ++ ++K F
Sbjct: 361 RMSWSDEWVLKGISGYIYGLWMKKTF 386
>gi|212286172 RNA polymerase I polypeptide B isoform 2 [Homo
sapiens]
Length = 1079
Score = 35.8 bits (81), Expect = 0.21
Identities = 33/149 (22%), Positives = 61/149 (40%), Gaps = 11/149 (7%)
Query: 162 PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 221
PW ++ L +P+ + SL+P L T + VQ L + ++ + + ++
Sbjct: 535 PWMEVVL----IPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGT----MEQIFM 586
Query: 222 MSAVSSQEKQAEIL---EYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFS 278
A+ E A + E H ++++A + HN + + Y + GF +
Sbjct: 587 NVAIFEDEVFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLT 646
Query: 279 YTDESNEKKYFAATQFEPLAARSAFPCFD 307
Y D S+ K Y T PL S + +D
Sbjct: 647 YQDRSDNKLYRLQTPQSPLVRPSMYDYYD 675
>gi|33469941 RNA polymerase I polypeptide B isoform 1 [Homo sapiens]
Length = 1135
Score = 35.8 bits (81), Expect = 0.21
Identities = 33/149 (22%), Positives = 61/149 (40%), Gaps = 11/149 (7%)
Query: 162 PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 221
PW ++ L +P+ + SL+P L T + VQ L + ++ + + ++
Sbjct: 591 PWMEVVL----IPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGT----MEQIFM 642
Query: 222 MSAVSSQEKQAEIL---EYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFS 278
A+ E A + E H ++++A + HN + + Y + GF +
Sbjct: 643 NVAIFEDEVFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLT 702
Query: 279 YTDESNEKKYFAATQFEPLAARSAFPCFD 307
Y D S+ K Y T PL S + +D
Sbjct: 703 YQDRSDNKLYRLQTPQSPLVRPSMYDYYD 731
>gi|89941479 hypothetical protein LOC148137 [Homo sapiens]
Length = 425
Score = 32.0 bits (71), Expect = 3.1
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 7/113 (6%)
Query: 804 QQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDD-WMASNGTQSLPTDVMTT 862
Q QTW + R RS L + G S +LF++ W +S+GT SLP+
Sbjct: 29 QSQTWCPKTLSPSRSQRSRLPQAPKALATGPNSP---ELFEESWPSSSGTPSLPSTTEGQ 85
Query: 863 VFKVGAKT--DKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSS 913
++ A T D G S ++ KYI+ +A+ E + +WL S
Sbjct: 86 MWASPAPTLIDSGDS-VVAKYINRFRQAQPTSREERQPAGPTPADFWWLQSDS 137
>gi|51988900 XPG-complementing protein [Homo sapiens]
Length = 1186
Score = 30.8 bits (68), Expect = 6.8
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 36 LHPLEPDEVEYEPRGSRLLVRGLGEHEMEE-DEEDYESSAKLLGMSFMNRSSGLRNSATG 94
L +E V E +L++G+ + E D E SS+K+ GMSF +SS T
Sbjct: 273 LKEVESRRVVSEDTSHYILIKGIQAKTVAEVDSESLPSSSKMHGMSFDVKSSPCEKLKT- 331
Query: 95 YRQSPDGACSVPSARTMV 112
+ PD + PS RT++
Sbjct: 332 -EKEPD--ATPPSPRTLL 346
>gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens]
Length = 2354
Score = 30.8 bits (68), Expect = 6.8
Identities = 35/185 (18%), Positives = 75/185 (40%), Gaps = 41/185 (22%)
Query: 499 EKIFKELSSYEDFLDARFKTMK----KDSLNSSHPISSSVQ----SSEQIEEM------F 544
E++ KE+S +++ +D K +K + + +S P+ S ++++I +
Sbjct: 1258 EEVVKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCL 1317
Query: 545 DSLSYFKGSSLLLMLKTYLSEDVF--------QHAVVLYLHNHSYASIQSDDLWDSFNEV 596
D Y S ++ + + V +HA + ++SY+ +S D DSF
Sbjct: 1318 DDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAA 1377
Query: 597 TNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPL 656
++ + + W K ++++ + + L D SY HIP+
Sbjct: 1378 ADELQKPVKEINLW-------------KEDHIYLEDKSYKLG------DFDVSYASHIPV 1418
Query: 657 SYVTE 661
+VT+
Sbjct: 1419 QFVTD 1423
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 30.4 bits (67), Expect = 8.9
Identities = 25/96 (26%), Positives = 44/96 (45%), Gaps = 12/96 (12%)
Query: 530 ISSSVQSSEQIEEMFDSLSYF------KGSSL---LLMLKTYLSE--DVFQHAVVLYLHN 578
+ S++ + Q EMF S + K SL L+ ++ LS+ ++ + Y H
Sbjct: 561 LESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHL 620
Query: 579 HSYASIQSDDLWDSFN-EVTNQTLDVKRMMKTWTLQ 613
S S DDLW+ N + N+ L+ + + W +Q
Sbjct: 621 ESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQ 656
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,043,098
Number of Sequences: 37866
Number of extensions: 1467440
Number of successful extensions: 3800
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3699
Number of HSP's gapped (non-prelim): 24
length of query: 1025
length of database: 18,247,518
effective HSP length: 112
effective length of query: 913
effective length of database: 14,006,526
effective search space: 12787958238
effective search space used: 12787958238
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.