Guide to the Human Genome
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Search of human proteins with 5922001

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1B isoform c [Homo sapiens]
         (601 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...  1236   0.0  
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...  1221   0.0  
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...  1201   0.0  
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...   696   0.0  
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...   692   0.0  
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...   684   0.0  
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...   676   0.0  
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...   670   0.0  
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   290   2e-78
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   281   1e-75
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   281   1e-75
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...   263   4e-70
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...   263   4e-70
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...   215   8e-56
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...   215   8e-56
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...   209   4e-54
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...   209   4e-54
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...   206   6e-53
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...   206   6e-53
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          185   9e-47
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]               184   2e-46
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                184   2e-46
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   184   3e-46
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          182   6e-46
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               182   8e-46
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]               182   8e-46
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      174   3e-43
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]             147   3e-35
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]              147   3e-35
gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]           139   7e-33

>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score = 1236 bits (3197), Expect = 0.0
 Identities = 601/601 (100%), Positives = 601/601 (100%)

Query: 1   MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
           MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
Sbjct: 1   MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60

Query: 61  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
           EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
Sbjct: 61  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120

Query: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
           SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
Sbjct: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180

Query: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
           MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
Sbjct: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240

Query: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
           KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
Sbjct: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300

Query: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
           CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
Sbjct: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360

Query: 361 KELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA 420
           KELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA
Sbjct: 361 KELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA 420

Query: 421 STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP 480
           STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP
Sbjct: 421 STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP 480

Query: 481 PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSL 540
           PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSL
Sbjct: 481 PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSL 540

Query: 541 VGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAAS 600
           VGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAAS
Sbjct: 541 VGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAAS 600

Query: 601 S 601
           S
Sbjct: 601 S 601


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score = 1221 bits (3158), Expect = 0.0
 Identities = 601/629 (95%), Positives = 601/629 (95%), Gaps = 28/629 (4%)

Query: 1   MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
           MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
Sbjct: 1   MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60

Query: 61  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
           EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
Sbjct: 61  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120

Query: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
           SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
Sbjct: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180

Query: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
           MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
Sbjct: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240

Query: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
           KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
Sbjct: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300

Query: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
           CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
Sbjct: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360

Query: 361 KELRKDYQGPGTRRLQE----------------------------DLVLRMLEYEPAARI 392
           KELRKDYQGPGTRRLQE                            DLVLRMLEYEPAARI
Sbjct: 361 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 420

Query: 393 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 452
           SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
Sbjct: 421 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 480

Query: 453 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 512
           RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
Sbjct: 481 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 540

Query: 513 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 572
           QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
Sbjct: 541 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 600

Query: 573 PPLPPPDDPATLGPHLGLRGVPQSTAASS 601
           PPLPPPDDPATLGPHLGLRGVPQSTAASS
Sbjct: 601 PPLPPPDDPATLGPHLGLRGVPQSTAASS 629


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score = 1201 bits (3108), Expect = 0.0
 Identities = 589/601 (98%), Positives = 589/601 (98%), Gaps = 12/601 (1%)

Query: 1   MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
           MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
Sbjct: 1   MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60

Query: 61  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
           EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
Sbjct: 61  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120

Query: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
           SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
Sbjct: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180

Query: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
           MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
Sbjct: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240

Query: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
           KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
Sbjct: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300

Query: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
           CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
Sbjct: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360

Query: 361 KELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA 420
           KELRK            DLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA
Sbjct: 361 KELRK------------DLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSA 408

Query: 421 STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP 480
           STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP
Sbjct: 409 STSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP 468

Query: 481 PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSL 540
           PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSL
Sbjct: 469 PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSL 528

Query: 541 VGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAAS 600
           VGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAAS
Sbjct: 529 VGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAAS 588

Query: 601 S 601
           S
Sbjct: 589 S 589


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score =  696 bits (1795), Expect = 0.0
 Identities = 356/509 (69%), Positives = 406/509 (79%), Gaps = 38/509 (7%)

Query: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128

Query: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188

Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248

Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308

Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368

Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ---- 376
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L     
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428

Query: 377 ------------------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 412
                                   +DL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488

Query: 413 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 466
           T    +S STSPA   +  S +T+S+ SSSGGSSG+S+  R      + +R+ GG     
Sbjct: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545

Query: 467 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 494
               DCE +SPQV    P    W+G + P
Sbjct: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score =  692 bits (1786), Expect = 0.0
 Identities = 352/493 (71%), Positives = 400/493 (81%), Gaps = 37/493 (7%)

Query: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128

Query: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188

Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248

Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308

Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368

Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ---- 376
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L     
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428

Query: 377 ------------------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 412
                                   +DL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488

Query: 413 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 466
           T    +S STSPA   +  S +T+S+ SSSGGSSG+S+  R      + +R+ GG     
Sbjct: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545

Query: 467 PPITDCEMNSPQV 479
               DCE +SPQV
Sbjct: 546 VQAMDCETHSPQV 558


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score =  684 bits (1766), Expect = 0.0
 Identities = 351/499 (70%), Positives = 398/499 (79%), Gaps = 38/499 (7%)

Query: 31  RRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNH 90
           RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS+KKE+KV N 
Sbjct: 70  RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND 129

Query: 91  GYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLN 150
           GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIKIIKNKKAFLN
Sbjct: 130 GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLN 189

Query: 151 QAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS 210
           QAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDLLRNT+FRGVS
Sbjct: 190 QAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS 249

Query: 211 LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 270
           LNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI
Sbjct: 250 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 309

Query: 271 YQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG 330
           YQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVDQMN+IVEVLG
Sbjct: 310 YQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG 369

Query: 331 IPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ-------------- 376
           IPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L               
Sbjct: 370 IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR 429

Query: 377 --------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 422
                         +DL+LRML+Y+P  RI P  ALQH FF++TADE TNT    +S ST
Sbjct: 430 AGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVST 486

Query: 423 SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PGPPITDCEMNS 476
           SPA   +  S +T+S+ SSSGGSSG+S+  R      + +R+ GG         DCE +S
Sbjct: 487 SPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHS 546

Query: 477 PQVPPSQPL-RPWAGGDVP 494
           PQV    P    W+G + P
Sbjct: 547 PQVRQQFPAPLGWSGTEAP 565


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score =  676 bits (1743), Expect = 0.0
 Identities = 341/465 (73%), Positives = 384/465 (82%), Gaps = 32/465 (6%)

Query: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128

Query: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188

Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248

Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308

Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368

Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ---- 376
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L     
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428

Query: 377 ------------------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 412
                                   +DL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488

Query: 413 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRY 457
           T    +S STSPA ++   SS T SS SSS G+S  S  +   R+
Sbjct: 489 T---SNSVSTSPA-MEQSQSSGTTSSTSSSSGASAISCSSWLVRH 529


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score =  670 bits (1728), Expect = 0.0
 Identities = 337/450 (74%), Positives = 377/450 (83%), Gaps = 32/450 (7%)

Query: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128

Query: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188

Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248

Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308

Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368

Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ---- 376
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L     
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428

Query: 377 ------------------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 412
                                   +DL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488

Query: 413 TGPAGSSASTSPAPLDTCPSSSTASSISSS 442
           T    +S STSPA ++   SS T SS SSS
Sbjct: 489 T---SNSVSTSPA-MEQSQSSGTTSSTSSS 514


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  290 bits (743), Expect = 2e-78
 Identities = 162/399 (40%), Positives = 238/399 (59%), Gaps = 19/399 (4%)

Query: 41  TSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYI 100
           T+A   KL  + +  Y+    + YA+      +A   D++ +K  K     +DD++  Y+
Sbjct: 37  TAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKT---SFDDEHGFYL 93

Query: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
               +    RYE+   IGKGSFGQV K  DH+  ELVA+KII+NKK F  QA +EL++LE
Sbjct: 94  KVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILE 153

Query: 161 LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ 220
            + + D +  Y +VH+K  F FRNH C+ FELL  NLY+L++N +F+G SL++ R+    
Sbjct: 154 ALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLS 213

Query: 221 LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 280
           +   L  L+  +  IIHCDLKPENI+L    ++++K++DFGSSC   Q++Y YIQSRFYR
Sbjct: 214 VLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYR 271

Query: 281 SPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA 340
           SPEV+LG PYD+AIDMWSLGCI  E++TG PLF G NEV+Q+  I+EVLG+PPA  +  A
Sbjct: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331

Query: 341 PKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQE----------DLVLRMLEYEPAA 390
            + + +F+     G+    T   R   + P ++ L            D + R L +EP+ 
Sbjct: 332 SRRQTFFD---SKGFPKNITNN-RGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSL 387

Query: 391 RISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDT 429
           R++P  AL+H +  ++ +      P     S S  P +T
Sbjct: 388 RMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSET 426


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  281 bits (719), Expect = 1e-75
 Identities = 162/389 (41%), Positives = 222/389 (57%), Gaps = 33/389 (8%)

Query: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
           N GYDDD   Y+    +    RYE+  +IGKGSFGQVVKAYDH+  + VA+K+++N+K F
Sbjct: 200 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 259

Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
             QA  E+R+LE + + D +    ++H+  +F FRNH+C+ FELLS NLY+L++   F+G
Sbjct: 260 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 319

Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
            SL L RK A  +   L   A  +  IIHCDLKPENILL    RS IK++DFGSSC   Q
Sbjct: 320 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 377

Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
           R+Y YIQSRFYR+PEV+LG  Y + IDMWSLGCIL E+ TG PL  G +E DQ+  ++E+
Sbjct: 378 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 437

Query: 329 LGIPPAAMLDQAPKARKYFE-----------RLPGGGWTLRRTKELRKDYQGPGTRR--- 374
           LG+P   +LD + +A+ +              L  G   L   +  R   +GP   R   
Sbjct: 438 LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWG 497

Query: 375 ---------LQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPA 425
                    L  D + + LE++PA R++P  AL+H + RR   +     P G   S    
Sbjct: 498 NALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PTGEKTSVK-- 551

Query: 426 PLDTCPSSSTASSISSSGGSSGSSSDNRT 454
                 S+   +SIS     S S+S  RT
Sbjct: 552 --RITESTGAITSISKLPPPSSSASKLRT 578


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  281 bits (719), Expect = 1e-75
 Identities = 162/389 (41%), Positives = 222/389 (57%), Gaps = 33/389 (8%)

Query: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
           N GYDDD   Y+    +    RYE+  +IGKGSFGQVVKAYDH+  + VA+K+++N+K F
Sbjct: 127 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 186

Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
             QA  E+R+LE + + D +    ++H+  +F FRNH+C+ FELLS NLY+L++   F+G
Sbjct: 187 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 246

Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
            SL L RK A  +   L   A  +  IIHCDLKPENILL    RS IK++DFGSSC   Q
Sbjct: 247 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 304

Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
           R+Y YIQSRFYR+PEV+LG  Y + IDMWSLGCIL E+ TG PL  G +E DQ+  ++E+
Sbjct: 305 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 364

Query: 329 LGIPPAAMLDQAPKARKYFE-----------RLPGGGWTLRRTKELRKDYQGPGTRR--- 374
           LG+P   +LD + +A+ +              L  G   L   +  R   +GP   R   
Sbjct: 365 LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWG 424

Query: 375 ---------LQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPA 425
                    L  D + + LE++PA R++P  AL+H + RR   +     P G   S    
Sbjct: 425 NALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PTGEKTSVK-- 478

Query: 426 PLDTCPSSSTASSISSSGGSSGSSSDNRT 454
                 S+   +SIS     S S+S  RT
Sbjct: 479 --RITESTGAITSISKLPPPSSSASKLRT 505


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score =  263 bits (671), Expect = 4e-70
 Identities = 144/349 (41%), Positives = 211/349 (60%), Gaps = 27/349 (7%)

Query: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
           N GYDD +  YI    +    RYE+  +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 167 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 226

Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
             QA  E+R+LE + + D      ++H+   F FRNH+C+ FELLS +LY+L++   F+G
Sbjct: 227 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 286

Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
            S+ L RK AQ +  +L   A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q
Sbjct: 287 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 344

Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
           ++Y YIQSRFYR+PE++LG+ Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+
Sbjct: 345 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 404

Query: 329 LGIPPAAMLDQAPKARKYFERLPG------------------GGWTLRRTKELRKDYQGP 370
           LG+PP  +L+Q+ +A KYF    G                  GG + R  K      +  
Sbjct: 405 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 463

Query: 371 GTR------RLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 413
           GT        L  + + R L ++P+AR++P  AL+H +  ++      T
Sbjct: 464 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 512


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score =  263 bits (671), Expect = 4e-70
 Identities = 144/349 (41%), Positives = 211/349 (60%), Gaps = 27/349 (7%)

Query: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
           N GYDD +  YI    +    RYE+  +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246

Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
             QA  E+R+LE + + D      ++H+   F FRNH+C+ FELLS +LY+L++   F+G
Sbjct: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306

Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
            S+ L RK AQ +  +L   A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q
Sbjct: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364

Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
           ++Y YIQSRFYR+PE++LG+ Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+
Sbjct: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424

Query: 329 LGIPPAAMLDQAPKARKYFERLPG------------------GGWTLRRTKELRKDYQGP 370
           LG+PP  +L+Q+ +A KYF    G                  GG + R  K      +  
Sbjct: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483

Query: 371 GTR------RLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 413
           GT        L  + + R L ++P+AR++P  AL+H +  ++      T
Sbjct: 484 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
           [Homo sapiens]
          Length = 1210

 Score =  215 bits (548), Expect = 8e-56
 Identities = 125/335 (37%), Positives = 185/335 (55%), Gaps = 42/335 (12%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           YE+   +G+G+FGQV K +   T+E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426

Query: 348 ERLPGGGWTLRR--------------TKELRK----------------DYQGP------G 371
            R P  G+ L R              +KE RK                D +G        
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486

Query: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406
            RR   DL+ +ML  +   RI+PL  L H F   T
Sbjct: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
           [Homo sapiens]
          Length = 1075

 Score =  215 bits (548), Expect = 8e-56
 Identities = 125/335 (37%), Positives = 185/335 (55%), Gaps = 42/335 (12%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           YE+   +G+G+FGQV K +   T+E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426

Query: 348 ERLPGGGWTLRR--------------TKELRK----------------DYQGP------G 371
            R P  G+ L R              +KE RK                D +G        
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486

Query: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406
            RR   DL+ +ML  +   RI+PL  L H F   T
Sbjct: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521


>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
           [Homo sapiens]
          Length = 1171

 Score =  209 bits (533), Expect = 4e-54
 Identities = 124/335 (37%), Positives = 183/335 (54%), Gaps = 42/335 (12%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++    +  
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435

Query: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371
            R    P   W L+           ++KE RK                D +G        
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKA 495

Query: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406
            RR   DL+ +ML  +   RI+P+  L H F   T
Sbjct: 496 DRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
           [Homo sapiens]
          Length = 1198

 Score =  209 bits (533), Expect = 4e-54
 Identities = 124/335 (37%), Positives = 183/335 (54%), Gaps = 42/335 (12%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++    +  
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435

Query: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371
            R    P   W L+           ++KE RK                D +G        
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKA 495

Query: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406
            RR   DL+ +ML  +   RI+P+  L H F   T
Sbjct: 496 DRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
           [Homo sapiens]
          Length = 1194

 Score =  206 bits (523), Expect = 6e-53
 Identities = 122/331 (36%), Positives = 184/331 (55%), Gaps = 42/331 (12%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
           Y  V     F  RNH CLVFE+L  NLYD L+   F  + L + R + QQ+ TAL  L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
            P+  AIDMWSLGC++ E+  G PL+ G+ E DQ+  I +  G+P   +L+   K+ ++F
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433

Query: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371
            +   +   GW L+           ++KE RK                D +G        
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKA 493

Query: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGF 402
            RR    L+ +ML  +   RI+P   L H F
Sbjct: 494 DRREFVSLLKKMLLIDADLRITPAETLNHPF 524


>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
           [Homo sapiens]
          Length = 1215

 Score =  206 bits (523), Expect = 6e-53
 Identities = 122/331 (36%), Positives = 184/331 (55%), Gaps = 42/331 (12%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
           Y  V     F  RNH CLVFE+L  NLYD L+   F  + L + R + QQ+ TAL  L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
            P+  AIDMWSLGC++ E+  G PL+ G+ E DQ+  I +  G+P   +L+   K+ ++F
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433

Query: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371
            +   +   GW L+           ++KE RK                D +G        
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKA 493

Query: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGF 402
            RR    L+ +ML  +   RI+P   L H F
Sbjct: 494 DRREFVSLLKKMLLIDADLRITPAETLNHPF 524


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  185 bits (470), Expect = 9e-47
 Identities = 122/377 (32%), Positives = 196/377 (51%), Gaps = 35/377 (9%)

Query: 64  YAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWL-ERYEIDSLIGKGSF 122
           + +++RR++      S + +  K +    +DD   +++     WL ERYEI S +G+G+F
Sbjct: 118 HRRRRRRSRTFSRSSSHSSRRAKSV----EDDAEGHLIYHVGDWLQERYEIVSTLGEGTF 173

Query: 123 GQVVKAYDHQT-QELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFM 181
           G+VV+  DH+     VA+KIIKN + +   A++E+ +LE +N+ D + K   V +   F 
Sbjct: 174 GRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD 233

Query: 182 FRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLK 241
           +  H+C+ FELL  + +D L++ ++    ++  R +A QLC A+ FL   +L+  H DLK
Sbjct: 234 YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLK 291

Query: 242 PENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEV 284
           PENIL  N                  K +A+++VDFGS+    +     + +R YR+PEV
Sbjct: 292 PENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEV 351

Query: 285 LLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKAR 344
           +L   +    D+WS+GCI+ E + G  LF   +  + +  +  +LG  P+ M+ +  K +
Sbjct: 352 ILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRK-Q 410

Query: 345 KYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLEYEPAARISPL 395
           KYF        E    G +     K LR+          Q  DL+  MLEYEPA R++  
Sbjct: 411 KYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG 470

Query: 396 GALQHGFFRRTADEATN 412
            ALQH FF R   E  N
Sbjct: 471 EALQHPFFARLRAEPPN 487


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score =  184 bits (467), Expect = 2e-46
 Identities = 124/378 (32%), Positives = 195/378 (51%), Gaps = 41/378 (10%)

Query: 55  TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
           +YK  + ++++   RR        S  K  ++      +DD   +++ +SG+    RYEI
Sbjct: 154 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 205

Query: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
              +G+G+FG+VV+  DH+     VA+KI+KN   +   A+ E+++LE +N  D    + 
Sbjct: 206 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 265

Query: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
            V +   F    H+C+VFELL  + YD ++   F    L+  RK+A Q+C ++ FL + +
Sbjct: 266 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 325

Query: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
           L+  H DLKPENIL          NPK            IK+VDFGS+    +     + 
Sbjct: 326 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 383

Query: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
           +R YR+PEV+L   +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P  
Sbjct: 384 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 443

Query: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDY--QGPGTRRLQEDLVLRMLE 385
           M+ Q  + RKYF        E    G +  RR K L++    Q     RL  DL+ +MLE
Sbjct: 444 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERL-FDLIQKMLE 501

Query: 386 YEPAARISPLGALQHGFF 403
           Y+PA RI+   AL+H FF
Sbjct: 502 YDPAKRITLREALKHPFF 519


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score =  184 bits (467), Expect = 2e-46
 Identities = 124/378 (32%), Positives = 195/378 (51%), Gaps = 41/378 (10%)

Query: 55  TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
           +YK  + ++++   RR        S  K  ++      +DD   +++ +SG+    RYEI
Sbjct: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163

Query: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
              +G+G+FG+VV+  DH+     VA+KI+KN   +   A+ E+++LE +N  D    + 
Sbjct: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223

Query: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
            V +   F    H+C+VFELL  + YD ++   F    L+  RK+A Q+C ++ FL + +
Sbjct: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283

Query: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
           L+  H DLKPENIL          NPK            IK+VDFGS+    +     + 
Sbjct: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341

Query: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
           +R YR+PEV+L   +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P  
Sbjct: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401

Query: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDY--QGPGTRRLQEDLVLRMLE 385
           M+ Q  + RKYF        E    G +  RR K L++    Q     RL  DL+ +MLE
Sbjct: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERL-FDLIQKMLE 459

Query: 386 YEPAARISPLGALQHGFF 403
           Y+PA RI+   AL+H FF
Sbjct: 460 YDPAKRITLREALKHPFF 477


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  184 bits (466), Expect = 3e-46
 Identities = 126/353 (35%), Positives = 180/353 (50%), Gaps = 54/353 (15%)

Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
           Y+I  ++GKG+FG+V K +   T E+VAIKI+KN        + EL+LL  M   D E +
Sbjct: 11  YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE-E 69

Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
            +++     F       LVFELL  NL++  +  +F  +     R +  Q+ TAL  L  
Sbjct: 70  AHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK- 128

Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPEVL 285
            EL+IIH DLKPENI+L +  R    +K++DFGS+    +  Y    YIQSRFYR+PE+L
Sbjct: 129 -ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEIL 187

Query: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARK 345
           LG P+   +D+WSLGC++ E+H G PL+ G+NE DQ+  I E  G+P   +L  A KA  
Sbjct: 188 LGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHH 247

Query: 346 YFERLP----GGGWTLRRTKEL----------RKDYQ--------------------GPG 371
           +F+R P       W L+ + +           R+ Y                      P 
Sbjct: 248 FFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPD 307

Query: 372 TRRLQE--------DLVLRMLEYEPAARISPLGALQHGFFR----RTADEATN 412
              L E        +L+ RML +E   RISP  AL+H F      R+A E T+
Sbjct: 308 REALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  182 bits (463), Expect = 6e-46
 Identities = 118/366 (32%), Positives = 189/366 (51%), Gaps = 33/366 (9%)

Query: 67  KKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEIDSLIGKGSFGQV 125
           K++R +      S +K  ++  +   +DD   +++ +SG+    RYEI   +G+G+FG+V
Sbjct: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173

Query: 126 VKAYDHQTQEL-VAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRN 184
           V+  DH    + VA+KI+KN   +   A+ E+++LE +N  D    +  V +   F    
Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233

Query: 185 HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN 244
           H+C+VFELL  + YD ++   F    ++  R++A Q+C ++ FL   +L+  H DLKPEN
Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291

Query: 245 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 287
           IL                     K + IK+VDFGS+    +     + +R YR+PEV+L 
Sbjct: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351

Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
             +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P  M+ Q  + RKYF
Sbjct: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMI-QKTRKRKYF 410

Query: 348 --------ERLPGGGWTLRRTKELRKDYQGPGTRRLQE--DLVLRMLEYEPAARISPLGA 397
                   E    G +  RR K L K++        ++  DLV RMLEY+P  RI+   A
Sbjct: 411 HHNQLDWDEHSSAGRYVRRRCKPL-KEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEA 469

Query: 398 LQHGFF 403
           LQH FF
Sbjct: 470 LQHPFF 475


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  182 bits (462), Expect = 8e-46
 Identities = 123/378 (32%), Positives = 193/378 (51%), Gaps = 35/378 (9%)

Query: 54  KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
           +T KH +  +    KRR +      S +++  K  +   +DD   ++V R G+   ERYE
Sbjct: 250 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 305

Query: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
           I   +G+G+FG+VV+  DH + +  VA+KII+N   +   A++E+ +L+ + + D E K+
Sbjct: 306 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 365

Query: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
             V +   F F  H+C+ FELL  N ++ L+  +F+   L   R +A QLC AL FL   
Sbjct: 366 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 425

Query: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
           +L+  H DLKPENIL  N                  K ++I++ DFGS+    +     +
Sbjct: 426 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 483

Query: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
            +R YR PEV+L   +    D+WS+GCIL E + G  LF      + +  + ++LG  P+
Sbjct: 484 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 543

Query: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLE 385
            M+ +  K +KYF        E    G +     K L+          +Q  DL+ RMLE
Sbjct: 544 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLE 602

Query: 386 YEPAARISPLGALQHGFF 403
           ++PA RI+   AL H FF
Sbjct: 603 FDPAQRITLAEALLHPFF 620


>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
          Length = 490

 Score =  182 bits (462), Expect = 8e-46
 Identities = 123/378 (32%), Positives = 193/378 (51%), Gaps = 35/378 (9%)

Query: 54  KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
           +T KH +  +    KRR +      S +++  K  +   +DD   ++V R G+   ERYE
Sbjct: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157

Query: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
           I   +G+G+FG+VV+  DH + +  VA+KII+N   +   A++E+ +L+ + + D E K+
Sbjct: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217

Query: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
             V +   F F  H+C+ FELL  N ++ L+  +F+   L   R +A QLC AL FL   
Sbjct: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277

Query: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
           +L+  H DLKPENIL  N                  K ++I++ DFGS+    +     +
Sbjct: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335

Query: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
            +R YR PEV+L   +    D+WS+GCIL E + G  LF      + +  + ++LG  P+
Sbjct: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395

Query: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLE 385
            M+ +  K +KYF        E    G +     K L+          +Q  DL+ RMLE
Sbjct: 396 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLE 454

Query: 386 YEPAARISPLGALQHGFF 403
           ++PA RI+   AL H FF
Sbjct: 455 FDPAQRITLAEALLHPFF 472


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  174 bits (440), Expect = 3e-43
 Identities = 118/349 (33%), Positives = 183/349 (52%), Gaps = 30/349 (8%)

Query: 83   KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDH-QTQELVAIKI 141
            KE   L   + D    Y V  GE   +RY +    G+G F  VV+A D+ +  + VA+KI
Sbjct: 659  KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKI 718

Query: 142  IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201
            I+N +        EL  L+ +N  D + K++ + L RHF  + HLCLVFE LS NL ++L
Sbjct: 719  IRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVL 778

Query: 202  RNTHFR-GVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
            +      G+ +   R  +QQL  AL  L     +I+H D+KP+NIL+ N  ++ +K+ DF
Sbjct: 779  KKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNILV-NESKTILKLCDF 835

Query: 261  GSSCQLGQR-IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEV 319
            GS+  +    I  Y+ SRFYR+PE+++G  YD  IDMWS+GC L E++TG+ LF G    
Sbjct: 836  GSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNN 895

Query: 320  DQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGW----------------TLRRTKEL 363
              +   +++ G  P  M+ +     ++F++     +                T+  TK+L
Sbjct: 896  HMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDL 955

Query: 364  RKDYQG----PGTRRLQ----EDLVLRMLEYEPAARISPLGALQHGFFR 404
              D  G    P  +R +    +DL+ ++L  +PA RIS   ALQH F +
Sbjct: 956  LADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004


>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  147 bits (371), Expect = 3e-35
 Identities = 113/354 (31%), Positives = 182/354 (51%), Gaps = 29/354 (8%)

Query: 108 LERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDT 167
           + ++EI  ++G+G++G V+K    +T E+VAIK  K+ +      +  LR L+++    T
Sbjct: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66

Query: 168 EMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLF 227
             +  IV LK  F  R  L LVFE +  N+ +LL      GV     +    QL  A+ +
Sbjct: 67  LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125

Query: 228 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 283
               +  I+H D+KPEN+L+ +     +K+ DFG +  L +       +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181

Query: 284 VLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG-IPPAAMLDQAPK 342
           +LLG PY  ++DMWS+GCIL E+  G+PLF G +E+DQ+  I +VLG +P   M      
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN 241

Query: 343 ARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGF 402
            R +  R P     +   + L + Y G     +  DL+  +L+ +PA R      L H  
Sbjct: 242 PRFHGLRFP----AVNHPQSLERRYLGI-LNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 296

Query: 403 F--RRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRT 454
           F  +R  D + +      SA   P  ++    SST S+ + +G S+   S +R+
Sbjct: 297 FQTQRLLDRSPS-----RSAKRKPYHVE----SSTLSNRNQAGKSTALQSHHRS 341


>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  147 bits (371), Expect = 3e-35
 Identities = 113/354 (31%), Positives = 182/354 (51%), Gaps = 29/354 (8%)

Query: 108 LERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDT 167
           + ++EI  ++G+G++G V+K    +T E+VAIK  K+ +      +  LR L+++    T
Sbjct: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66

Query: 168 EMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLF 227
             +  IV LK  F  R  L LVFE +  N+ +LL      GV     +    QL  A+ +
Sbjct: 67  LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125

Query: 228 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 283
               +  I+H D+KPEN+L+ +     +K+ DFG +  L +       +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181

Query: 284 VLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG-IPPAAMLDQAPK 342
           +LLG PY  ++DMWS+GCIL E+  G+PLF G +E+DQ+  I +VLG +P   M      
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN 241

Query: 343 ARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGF 402
            R +  R P     +   + L + Y G     +  DL+  +L+ +PA R      L H  
Sbjct: 242 PRFHGLRFP----AVNHPQSLERRYLGI-LNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 296

Query: 403 F--RRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRT 454
           F  +R  D + +      SA   P  ++    SST S+ + +G S+   S +R+
Sbjct: 297 FQTQRLLDRSPS-----RSAKRKPYHVE----SSTLSNRNQAGKSTALQSHHRS 341


>gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
          Length = 483

 Score =  139 bits (350), Expect = 7e-33
 Identities = 108/329 (32%), Positives = 167/329 (50%), Gaps = 29/329 (8%)

Query: 116 LIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVH 175
           +IG GSFG V +A   +T+ELVAIK +   K F N+    +R L+  N       +Y   
Sbjct: 124 VIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 183

Query: 176 LKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNL----TRKLAQQLCTALLFLATP 231
            K+  ++ N   LV E +   +Y + R  HF    L +     +    QL  +L ++ + 
Sbjct: 184 EKKDELYLN---LVLEYVPETVYRVAR--HFTKAKLTIPILYVKVYMYQLFRSLAYIHSQ 238

Query: 232 ELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSPEVLLG-T 288
              + H D+KP+N+L+ +P  + +K+ DFGS+ QL  G+    YI SR+YR+PE++ G T
Sbjct: 239 --GVCHRDIKPQNLLV-DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 295

Query: 289 PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAML-DQAPKARKY- 346
            Y  +ID+WS GC+L E+  G+P+F G + VDQ+  I++VLG P    + +  P   ++ 
Sbjct: 296 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 355

Query: 347 FERLPGGGWTLRRTKELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGFF--- 403
           F ++    WT     ++ K    P    L   L    LEY P++R+SPL A  H FF   
Sbjct: 356 FPQIKAHPWT-----KVFKSRTPPEAIALCSSL----LEYTPSSRLSPLEACAHSFFDEL 406

Query: 404 RRTADEATNTGPAGSSASTSPAPLDTCPS 432
           R    +  N  P     + S   L   PS
Sbjct: 407 RCLGTQLPNNRPLPPLFNFSAGELSIQPS 435


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,807,370
Number of Sequences: 37866
Number of extensions: 1855148
Number of successful extensions: 23912
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 696
Number of HSP's successfully gapped in prelim test: 1524
Number of HSP's that attempted gapping in prelim test: 12457
Number of HSP's gapped (non-prelim): 7578
length of query: 601
length of database: 18,247,518
effective HSP length: 108
effective length of query: 493
effective length of database: 14,157,990
effective search space: 6979889070
effective search space used: 6979889070
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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