Search of human proteins with 5729937

Search of human proteins with 5729937

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729937 metaxin 2 [Homo sapiens]
         (263 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729937 metaxin 2 [Homo sapiens]                                   535   e-152
gi|38569475 metaxin 1 isoform 1 [Homo sapiens]                         99   5e-21
gi|148806867 metaxin 3 [Homo sapiens]                                  96   3e-20
gi|38569477 metaxin 1 isoform 2 [Homo sapiens]                         77   2e-14
gi|24308336 hypothetical protein LOC84553 [Homo sapiens]               67   1e-11
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ...    30   2.1  
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ...    30   2.1  
gi|115527120 nebulin [Homo sapiens]                                    29   3.7  
gi|51948366 ribonucleoprotein, PTB-binding 2 [Homo sapiens]            29   3.7  
gi|45827778 reticulon 1 isoform B [Homo sapiens]                       29   4.8  
gi|10863935 reticulon 1 isoform A [Homo sapiens]                       29   4.8  
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ...    28   6.2  
gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]              28   8.2  

>gi|5729937 metaxin 2 [Homo sapiens]
          Length = 263

 Score =  535 bits (1378), Expect = e-152
 Identities = 263/263 (100%), Positives = 263/263 (100%)

Query: 1   MSLVAEAFVSQIAAAEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCR 60
           MSLVAEAFVSQIAAAEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCR
Sbjct: 1   MSLVAEAFVSQIAAAEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCR 60

Query: 61  ANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNN 120
           ANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNN
Sbjct: 61  ANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNN 120

Query: 121 MLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLD 180
           MLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLD
Sbjct: 121 MLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLD 180

Query: 181 QVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYS 240
           QVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYS
Sbjct: 181 QVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYS 240

Query: 241 NLLAFCRRIEQHYFEDRGKGRLS 263
           NLLAFCRRIEQHYFEDRGKGRLS
Sbjct: 241 NLLAFCRRIEQHYFEDRGKGRLS 263


>gi|38569475 metaxin 1 isoform 1 [Homo sapiens]
          Length = 466

 Score = 98.6 bits (244), Expect = 5e-21
 Identities = 63/221 (28%), Positives = 107/221 (48%), Gaps = 8/221 (3%)

Query: 41  SLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGN-QVVSELGPIVQFVKAKGHSL 99
           SLAV  + +    P+KV   +N  + SPSG +P +   + +V+S    I+  ++ + ++ 
Sbjct: 172 SLAVLTYARFTGAPLKVHKISNP-WQSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNA 230

Query: 100 SDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAY 159
              L   Q A+  A+M L+   LL   ++  W D     E+T   Y    P+PLN  L  
Sbjct: 231 DYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPG 290

Query: 160 QKQWEVKRKMKAIGWGKKTLDQ------VLEDVDQCCQALSQRLGTQPYFFNKQPTELDA 213
           + Q +   +++ +    +  D+      +  +  +C   LSQRLG+Q +FF   P  LDA
Sbjct: 291 RMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDA 350

Query: 214 LVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYF 254
            VF +L  +L  +L + +L   ++   NL A+C  I   YF
Sbjct: 351 FVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYF 391


>gi|148806867 metaxin 3 [Homo sapiens]
          Length = 312

 Score = 95.9 bits (237), Expect = 3e-20
 Identities = 67/227 (29%), Positives = 105/227 (46%), Gaps = 7/227 (3%)

Query: 34  LLSDNAASLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVK 93
           L S ++ SL V A+ +    P+KV    N  +    G VP +   + +VS+   I+ F++
Sbjct: 16  LPSVHSESLVVMAYAKFSGAPLKVNVIDNT-WRGSRGDVPILTTEDDMVSQPAKILNFLR 74

Query: 94  AKGHSLSDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPL 153
            + ++    L   Q A+  AY+ L+   LL A L+  W +      +T   + S  P+PL
Sbjct: 75  KQKYNADYELSAKQGADTLAYIALLEEKLLPAVLHTFWVESDNYFTVTKPWFASQIPFPL 134

Query: 154 NHIL-AYQKQWEVKRKMKAIGWG-----KKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQ 207
           + IL     +  + R +   G       ++   Q+  D  +C   LS RLGT  +FF   
Sbjct: 135 SLILPGRMSKGALNRILLTRGQPPLYHLREVEAQIYRDAKECLNLLSNRLGTSQFFFGDT 194

Query: 208 PTELDALVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYF 254
           P+ LDA VFG L  +   +    +L E +K  SNL  FC  I   YF
Sbjct: 195 PSTLDAYVFGFLAPLYKVRFPKVQLQEHLKQLSNLCRFCDDILSSYF 241


>gi|38569477 metaxin 1 isoform 2 [Homo sapiens]
          Length = 435

 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 56/221 (25%), Positives = 94/221 (42%), Gaps = 39/221 (17%)

Query: 41  SLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGN-QVVSELGPIVQFVKAKGHSL 99
           SLAV  + +    P+KV   +N  + SPSG +P +   + +V+S    I+  ++ + H+ 
Sbjct: 172 SLAVLTYARFTGAPLKVHKISNP-WQSPSGTLPALRTSHGEVISVPHKIITHLRKEVHTF 230

Query: 100 SDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAY 159
                                          W D     E+T   Y    P+PLN  L  
Sbjct: 231 -------------------------------WIDTKNYVEVTRKWYAEAMPFPLNFFLPG 259

Query: 160 QKQWEVKRKMKAIGWGKKTLDQ------VLEDVDQCCQALSQRLGTQPYFFNKQPTELDA 213
           + Q +   +++ +    +  D+      +  +  +C   LSQRLG+Q +FF   P  LDA
Sbjct: 260 RMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDA 319

Query: 214 LVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYF 254
            VF +L  +L  +L + +L   ++   NL A+C  I   YF
Sbjct: 320 FVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYF 360


>gi|24308336 hypothetical protein LOC84553 [Homo sapiens]
          Length = 409

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 54/218 (24%), Positives = 104/218 (47%), Gaps = 7/218 (3%)

Query: 42  LAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAK-GHSLS 100
           L ++ +L+M +LP +         +S  GK+P+I   ++ VS    I+ F++ K G +L+
Sbjct: 120 LKMETYLRMADLPYQNYFGGK---LSAQGKMPWIEYNHEKVSGTEFIIDFLEEKLGVNLN 176

Query: 101 DGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEAT-VGEITHARYGSPYPWPLNHILAY 159
             L   ++A  +A  ++V         Y QW D      ++     G P+   L  ++ +
Sbjct: 177 KNLGPHERAISRAVTKMVEEHFYWTLAYCQWVDNLNETRKMLSLSGGGPFSNLLRWVVCH 236

Query: 160 QKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHL 219
             +  VKR+M   G G+ + +++   +++  ++L+  LG + Y    + + LDA VFGHL
Sbjct: 237 ITKGIVKREMHGHGIGRFSEEEIYMLMEKDMRSLAGLLGDKKYIMGPKLSTLDATVFGHL 296

Query: 220 YTILTTQLTNDELSEKVK-NYSNLLAFCRRIEQHYFED 256
              + T L        +K    NL  +C RI + ++ +
Sbjct: 297 AQAMWT-LPGTRPERLIKGELINLAMYCERIRRKFWPE 333


>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
            sapiens]
          Length = 5033

 Score = 30.0 bits (66), Expect = 2.1
 Identities = 20/82 (24%), Positives = 30/82 (36%), Gaps = 5/82 (6%)

Query: 149  YPWPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQP 208
            Y WP+   L     WE   +    G  +KT  +    + Q  Q    R G     +N QP
Sbjct: 2805 YRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREG-----YNPQP 2859

Query: 209  TELDALVFGHLYTILTTQLTND 230
             +L A+        +  QL  +
Sbjct: 2860 PDLSAVTLSRELQAMAEQLAEN 2881


>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
            sapiens]
          Length = 5038

 Score = 30.0 bits (66), Expect = 2.1
 Identities = 20/82 (24%), Positives = 30/82 (36%), Gaps = 5/82 (6%)

Query: 149  YPWPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQP 208
            Y WP+   L     WE   +    G  +KT  +    + Q  Q    R G     +N QP
Sbjct: 2805 YRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREG-----YNPQP 2859

Query: 209  TELDALVFGHLYTILTTQLTND 230
             +L A+        +  QL  +
Sbjct: 2860 PDLSAVTLSRELQAMAEQLAEN 2881


>gi|115527120 nebulin [Homo sapiens]
          Length = 6669

 Score = 29.3 bits (64), Expect = 3.7
 Identities = 16/35 (45%), Positives = 19/35 (54%), Gaps = 2/35 (5%)

Query: 65   YMSPSGKVPFIHVG--NQVVSELGPIVQFVKAKGH 97
            Y+ P   VPF+H    N V SEL    + VK KGH
Sbjct: 4226 YILPPDAVPFVHAHHCNDVQSELKYKAEHVKQKGH 4260


>gi|51948366 ribonucleoprotein, PTB-binding 2 [Homo sapiens]
          Length = 678

 Score = 29.3 bits (64), Expect = 3.7
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 3/57 (5%)

Query: 91  FVKAKGHSLSDGLEEVQKAEM--KAYMELVNNMLLTAELYLQWCD-EATVGEITHAR 144
           + +  GHS   G  E  K +   KA +EL+   L  + L+ QW D      E+ H++
Sbjct: 175 YSEVTGHSKGYGFVEYMKKDFAAKARLELLGRQLGASALFAQWMDVNLLASELIHSK 231


>gi|45827778 reticulon 1 isoform B [Homo sapiens]
          Length = 356

 Score = 28.9 bits (63), Expect = 4.8
 Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 21/109 (19%)

Query: 63  AEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNNML 122
           AE   PSG V F HVG    S   P +Q+           L E ++AE            
Sbjct: 3   AEDALPSGYVSFGHVGGPPPSPASPSIQY---------SILREEREAE------------ 41

Query: 123 LTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKA 171
           L +EL ++ CD ++  E +  R     P   + + A +++  V+ + +A
Sbjct: 42  LDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERA 90


>gi|10863935 reticulon 1 isoform A [Homo sapiens]
          Length = 776

 Score = 28.9 bits (63), Expect = 4.8
 Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 21/109 (19%)

Query: 63  AEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNNML 122
           AE   PSG V F HVG    S   P +Q+           L E ++AE            
Sbjct: 423 AEDALPSGYVSFGHVGGPPPSPASPSIQY---------SILREEREAE------------ 461

Query: 123 LTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKA 171
           L +EL ++ CD ++  E +  R     P   + + A +++  V+ + +A
Sbjct: 462 LDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERA 510


>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
           [Homo sapiens]
          Length = 1235

 Score = 28.5 bits (62), Expect = 6.2
 Identities = 45/197 (22%), Positives = 80/197 (40%), Gaps = 24/197 (12%)

Query: 26  QQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGNQVVSEL 85
           Q+LKG    L        +Q  +Q     +K   +   E +     V F    +Q+ SEL
Sbjct: 683 QELKGLMKTLRKETDLKQIQTLIQGTQTRLKY-SQNELEMIKKKHLVAFYQEQSQLQSEL 741

Query: 86  GPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEIT---- 141
             I    +++   LS+G++E Q+  +K + E ++ +    +++  +C+E  V  I     
Sbjct: 742 LNI----ESQCIMLSEGIKERQR-RIKEFQEKIDKV--EDDIFQHFCEEIGVENIREFEN 794

Query: 142 -HARYGSPYPWP----------LNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCC 190
            H +                  LN  L Y +   +K+K+  I   K+T+ +  ED+D   
Sbjct: 795 KHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRS-HLKKKLNKINTLKETIQKGSEDIDHLK 853

Query: 191 QALSQRLGTQPYFFNKQ 207
           +A    L T      KQ
Sbjct: 854 KAEENCLQTVNELMAKQ 870


>gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]
          Length = 1834

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 28/99 (28%), Positives = 40/99 (40%), Gaps = 7/99 (7%)

Query: 92  VKAKGHSLSDGLEEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITH-ARYGSPYP 150
           +K+K H      EE Q+   +A ME +     T    LQ    A  GE       GSP  
Sbjct: 834 LKSKDH------EEDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVS 887

Query: 151 WPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQC 189
             L   +  QKQW+   +M+ +  G+       E + QC
Sbjct: 888 GQLLAGVQVQKQWDKVEEMEPLEPGRDEAATTWEKMGQC 926


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,308,933
Number of Sequences: 37866
Number of extensions: 378131
Number of successful extensions: 860
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 850
Number of HSP's gapped (non-prelim): 14
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.