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Search of human proteins with 5454058
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
[Homo sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [H... 665 0.0
gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens] 202 3e-52
gi|28373086 sialyltransferase 6 isoform i [Homo sapiens] 198 5e-51
gi|28373082 sialyltransferase 6 isoform g [Homo sapiens] 198 5e-51
gi|28373078 sialyltransferase 6 isoform f [Homo sapiens] 198 5e-51
gi|28373070 sialyltransferase 6 isoform b [Homo sapiens] 198 5e-51
gi|28373068 sialyltransferase 6 isoform a [Homo sapiens] 198 5e-51
gi|5454060 sialyltransferase 6 isoform j [Homo sapiens] 198 5e-51
gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... 163 2e-40
gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... 163 2e-40
gi|28373074 sialyltransferase 6 isoform d [Homo sapiens] 129 5e-30
gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [... 108 7e-24
gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [H... 108 7e-24
gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [H... 103 3e-22
gi|21264332 sialyltransferase 7A [Homo sapiens] 83 4e-16
gi|192448440 sialyltransferase 7B [Homo sapiens] 73 3e-13
gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2... 71 1e-12
gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 ... 71 1e-12
gi|5031999 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf... 69 7e-12
gi|5174677 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf... 65 1e-10
gi|21361444 sialytransferase 7F [Homo sapiens] 63 4e-10
gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 i... 63 4e-10
gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ... 63 4e-10
gi|13569938 sialyltransferase 7E [Homo sapiens] 62 7e-10
gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2... 59 5e-09
gi|110815855 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltran... 59 6e-09
gi|28373101 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 55 9e-08
gi|229892273 sialyltransferase 7C isoform 1 [Homo sapiens] 52 6e-07
gi|28373092 sialyltransferase 7D isoform a [Homo sapiens] 52 7e-07
gi|229892275 sialyltransferase 7C isoform 2 [Homo sapiens] 49 8e-06
>gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Homo
sapiens]
Length = 329
Score = 665 bits (1716), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MVSKSRWKLLAMLALVLVVMVWYSISREDSFYFPIPEKKEPCLQGEAESKASKLFGNYSR 60
MVSKSRWKLLAMLALVLVVMVWYSISREDSFYFPIPEKKEPCLQGEAESKASKLFGNYSR
Sbjct: 1 MVSKSRWKLLAMLALVLVVMVWYSISREDSFYFPIPEKKEPCLQGEAESKASKLFGNYSR 60
Query: 61 DQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVG 120
DQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVG
Sbjct: 61 DQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVG 120
Query: 121 NGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPD 180
NGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPD
Sbjct: 121 NGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPD 180
Query: 181 TLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKL 240
TLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKL
Sbjct: 181 TLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKL 240
Query: 241 LSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM 300
LSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM
Sbjct: 241 LSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM 300
Query: 301 AGSGHNVSQEALAIKRMLEMGAIKNLTSF 329
AGSGHNVSQEALAIKRMLEMGAIKNLTSF
Sbjct: 301 AGSGHNVSQEALAIKRMLEMGAIKNLTSF 329
>gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens]
Length = 331
Score = 202 bits (514), Expect = 3e-52
Identities = 109/251 (43%), Positives = 156/251 (62%), Gaps = 5/251 (1%)
Query: 80 YELPYGTKGSEDLLLRVLA-ITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYD 138
++LPYG + S + L+ + S + ++ C++CVVVGNG L+N +LG+ I+ YD
Sbjct: 81 FDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYD 140
Query: 139 VVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIET 198
V+IR+NN PV G+E +VG +TT RLFYPES DP + N+P+T ++L AFK D W+
Sbjct: 141 VIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDP-IHNDPNTTVILTAFKPHDLRWLLE 199
Query: 199 ILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTT 257
+L K GFWK+P L P QIRIL+PF + AA +LL P P+ K K PTT
Sbjct: 200 LLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTT 259
Query: 258 GLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM-AGSGHNVSQEALAIKR 316
G++AITLA ++C VH+AGF Y + + K +HYY T+ M + HNV+ E L +K
Sbjct: 260 GIIAITLAFYICHEVHLAGFKY-NFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKD 318
Query: 317 MLEMGAIKNLT 327
++E + NLT
Sbjct: 319 IIEKNLVINLT 329
>gi|28373086 sialyltransferase 6 isoform i [Homo sapiens]
Length = 413
Score = 198 bits (504), Expect = 5e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 7/291 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 124 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 182
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 183 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 242
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL-SDKKRVRKGFWKQPPLIWD 219
+R+ YPE A P+ + D+L VL FK DF W++ I+ ++ GFWK
Sbjct: 243 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVP 301
Query: 220 VNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFG 278
P +IRILNP+F++ AA L+ LP + PT G +A+T+ALH CD V +AGFG
Sbjct: 302 KEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 361
Query: 279 YPDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRMLEMGAIKNLTS 328
Y D +HYYE + + ++ S HN+ +E ++++++ I +L+S
Sbjct: 362 Y-DMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSS 411
>gi|28373082 sialyltransferase 6 isoform g [Homo sapiens]
Length = 359
Score = 198 bits (504), Expect = 5e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 7/291 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 70 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 128
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 129 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 188
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL-SDKKRVRKGFWKQPPLIWD 219
+R+ YPE A P+ + D+L VL FK DF W++ I+ ++ GFWK
Sbjct: 189 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVP 247
Query: 220 VNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFG 278
P +IRILNP+F++ AA L+ LP + PT G +A+T+ALH CD V +AGFG
Sbjct: 248 KEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 307
Query: 279 YPDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRMLEMGAIKNLTS 328
Y D +HYYE + + ++ S HN+ +E ++++++ I +L+S
Sbjct: 308 Y-DMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSS 357
>gi|28373078 sialyltransferase 6 isoform f [Homo sapiens]
Length = 429
Score = 198 bits (504), Expect = 5e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 7/291 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 140 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 198
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 199 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 258
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL-SDKKRVRKGFWKQPPLIWD 219
+R+ YPE A P+ + D+L VL FK DF W++ I+ ++ GFWK
Sbjct: 259 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVP 317
Query: 220 VNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFG 278
P +IRILNP+F++ AA L+ LP + PT G +A+T+ALH CD V +AGFG
Sbjct: 318 KEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 377
Query: 279 YPDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRMLEMGAIKNLTS 328
Y D +HYYE + + ++ S HN+ +E ++++++ I +L+S
Sbjct: 378 Y-DMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSS 427
>gi|28373070 sialyltransferase 6 isoform b [Homo sapiens]
Length = 390
Score = 198 bits (504), Expect = 5e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 7/291 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 101 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 159
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 160 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 219
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL-SDKKRVRKGFWKQPPLIWD 219
+R+ YPE A P+ + D+L VL FK DF W++ I+ ++ GFWK
Sbjct: 220 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVP 278
Query: 220 VNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFG 278
P +IRILNP+F++ AA L+ LP + PT G +A+T+ALH CD V +AGFG
Sbjct: 279 KEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 338
Query: 279 YPDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRMLEMGAIKNLTS 328
Y D +HYYE + + ++ S HN+ +E ++++++ I +L+S
Sbjct: 339 Y-DMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSS 388
>gi|28373068 sialyltransferase 6 isoform a [Homo sapiens]
Length = 444
Score = 198 bits (504), Expect = 5e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 7/291 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 155 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 213
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 214 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 273
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL-SDKKRVRKGFWKQPPLIWD 219
+R+ YPE A P+ + D+L VL FK DF W++ I+ ++ GFWK
Sbjct: 274 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVP 332
Query: 220 VNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFG 278
P +IRILNP+F++ AA L+ LP + PT G +A+T+ALH CD V +AGFG
Sbjct: 333 KEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 392
Query: 279 YPDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRMLEMGAIKNLTS 328
Y D +HYYE + + ++ S HN+ +E ++++++ I +L+S
Sbjct: 393 Y-DMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSS 442
>gi|5454060 sialyltransferase 6 isoform j [Homo sapiens]
Length = 375
Score = 198 bits (504), Expect = 5e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 7/291 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 86 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 144
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 145 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 204
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL-SDKKRVRKGFWKQPPLIWD 219
+R+ YPE A P+ + D+L VL FK DF W++ I+ ++ GFWK
Sbjct: 205 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVP 263
Query: 220 VNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFG 278
P +IRILNP+F++ AA L+ LP + PT G +A+T+ALH CD V +AGFG
Sbjct: 264 KEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 323
Query: 279 YPDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRMLEMGAIKNLTS 328
Y D +HYYE + + ++ S HN+ +E ++++++ I +L+S
Sbjct: 324 Y-DMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSS 373
>gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 2 [Homo sapiens]
Length = 395
Score = 163 bits (412), Expect = 2e-40
Identities = 95/258 (36%), Positives = 150/258 (58%), Gaps = 10/258 (3%)
Query: 78 SAYELPYG-TKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINK 136
S Y+ P+G K S + + + +P+++++ CRRCVV+G+G L LG +N+
Sbjct: 133 SKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQ 192
Query: 137 YDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWI 196
+DVVIRLN+APV GY VG+KTT+R+ YPE A +E + L V V FK++DF+W+
Sbjct: 193 FDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS-DLEYYSNDLFVAVLFKSVDFNWL 251
Query: 197 ETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR---K 250
+ ++ + VR FWKQ + PK RILNP ++ A +L Q R +
Sbjct: 252 QAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGR 311
Query: 251 IKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM-AGSGHNVSQ 309
K PT G++A+ LA HLCD V +AGFGY D + +HY++ + +M + HNV+
Sbjct: 312 DKNVPTIGVIAVVLATHLCDEVSLAGFGY-DLNQPRTPLHYFDSQCMAAMNFQTMHNVTT 370
Query: 310 EALAIKRMLEMGAIKNLT 327
E + ++++ G +K+L+
Sbjct: 371 ETKFLLKLVKEGVVKDLS 388
>gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 1 [Homo sapiens]
Length = 418
Score = 163 bits (412), Expect = 2e-40
Identities = 95/258 (36%), Positives = 150/258 (58%), Gaps = 10/258 (3%)
Query: 78 SAYELPYG-TKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINK 136
S Y+ P+G K S + + + +P+++++ CRRCVV+G+G L LG +N+
Sbjct: 156 SKYDPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQ 215
Query: 137 YDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWI 196
+DVVIRLN+APV GY VG+KTT+R+ YPE A +E + L V V FK++DF+W+
Sbjct: 216 FDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS-DLEYYSNDLFVAVLFKSVDFNWL 274
Query: 197 ETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR---K 250
+ ++ + VR FWKQ + PK RILNP ++ A +L Q R +
Sbjct: 275 QAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGR 334
Query: 251 IKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSM-AGSGHNVSQ 309
K PT G++A+ LA HLCD V +AGFGY D + +HY++ + +M + HNV+
Sbjct: 335 DKNVPTIGVIAVVLATHLCDEVSLAGFGY-DLNQPRTPLHYFDSQCMAAMNFQTMHNVTT 393
Query: 310 EALAIKRMLEMGAIKNLT 327
E + ++++ G +K+L+
Sbjct: 394 ETKFLLKLVKEGVVKDLS 411
>gi|28373074 sialyltransferase 6 isoform d [Homo sapiens]
Length = 277
Score = 129 bits (323), Expect = 5e-30
Identities = 70/166 (42%), Positives = 103/166 (62%), Gaps = 4/166 (2%)
Query: 42 CLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS 101
C G A + + +F +S+ P+FL W + + P+G KG ++L+ +L++T
Sbjct: 86 CKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIRE-FVPPFGIKGQDNLIKAILSVTK 144
Query: 102 S-SIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTT 160
+ + SLRCRRC++VGNG L N SLG I+ YD+V+RLN+APV G+E DVGSKTT
Sbjct: 145 EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTT 204
Query: 161 MRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRV 206
+R+ YPE A P+ + D+L VL FK DF W++ I+ K+RV
Sbjct: 205 LRITYPEGAMQRPE-QYERDSLFVLAGFKWQDFKWLKYIVY-KERV 248
>gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
[Homo sapiens]
Length = 340
Score = 108 bits (270), Expect = 7e-24
Identities = 67/185 (36%), Positives = 101/185 (54%), Gaps = 17/185 (9%)
Query: 109 QSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPES 168
+S+ CRRC VVGN LR SS G I+ +D V+R+N AP AG+E DVG+KTT L YPES
Sbjct: 135 RSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES 194
Query: 169 AHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRIL 228
E + ++LV FK +D W+ + ++ + + P I V +I I
Sbjct: 195 FR-----ELGDNVSMILVPFKTIDLEWVVSAIT-TGTISHTYIPVPAKI-RVKQDKILIY 247
Query: 229 NPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQT 288
+P F++ D L + + P+TG+L++ ++H+CD V + GFG A +K
Sbjct: 248 HPAFIKYVFDNWL-------QGHGRYPSTGILSVIFSMHVCDEVDLYGFG---ADSKGNW 297
Query: 289 IHYYE 293
HY+E
Sbjct: 298 HHYWE 302
>gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Homo
sapiens]
Length = 340
Score = 108 bits (270), Expect = 7e-24
Identities = 67/185 (36%), Positives = 101/185 (54%), Gaps = 17/185 (9%)
Query: 109 QSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPES 168
+S+ CRRC VVGN LR SS G I+ +D V+R+N AP AG+E DVG+KTT L YPES
Sbjct: 135 RSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES 194
Query: 169 AHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRIL 228
E + ++LV FK +D W+ + ++ + + P I V +I I
Sbjct: 195 FR-----ELGDNVSMILVPFKTIDLEWVVSAIT-TGTISHTYIPVPAKI-RVKQDKILIY 247
Query: 229 NPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQT 288
+P F++ D L + + P+TG+L++ ++H+CD V + GFG A +K
Sbjct: 248 HPAFIKYVFDNWL-------QGHGRYPSTGILSVIFSMHVCDEVDLYGFG---ADSKGNW 297
Query: 289 IHYYE 293
HY+E
Sbjct: 298 HHYWE 302
>gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Homo
sapiens]
Length = 350
Score = 103 bits (256), Expect = 3e-22
Identities = 64/182 (35%), Positives = 98/182 (53%), Gaps = 17/182 (9%)
Query: 112 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHF 171
+CRRC VVGN LR S G ++ ++ ++R+N AP G+E DVGS+TT YPESA
Sbjct: 148 QCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKN 207
Query: 172 DPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPF 231
P + VLV FK +D WI + LS ++R + + V+ ++++I NP
Sbjct: 208 LP-----ANVSFVLVPFKVLDLLWIASALS-TGQIRFTYAPVKSFL-RVDKEKVQIYNPA 260
Query: 232 FMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHY 291
F + D+ + P+TG+L + ALH+CD V++ GFG A ++ HY
Sbjct: 261 FFKYIHDR-------WTEHHGRYPSTGMLVLFFALHVCDEVNVYGFG---ADSRGNWHHY 310
Query: 292 YE 293
+E
Sbjct: 311 WE 312
>gi|21264332 sialyltransferase 7A [Homo sapiens]
Length = 600
Score = 82.8 bits (203), Expect = 4e-16
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 17/230 (7%)
Query: 110 SLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESA 169
SLRC C VVGNG L NS +G I+ +D V RL+ A + GYE DVG++T+ F S
Sbjct: 359 SLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSL 418
Query: 170 HFDPKVENN---------PDTLLVLVAFKAMDFHWIETILSDKKRVRKG-FW----KQPP 215
+ N D + D+ W+E +L ++ + K FW Q
Sbjct: 419 TQSLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLMNQTVMSKNLFWFRHRPQEA 478
Query: 216 LIWDVNPKQIRILNPFFMEIAADKLL-SLPMQQPRKIKQKPTTGLLAITLALHLCDLVHI 274
++ + +L+P F+ ++ L S + +PTTG L + AL LCD +
Sbjct: 479 FREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTALQLCD--QV 536
Query: 275 AGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIK 324
+ +G+ +++ + HYY+ + + H+ E KR+ + G I+
Sbjct: 537 SAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIR 586
>gi|192448440 sialyltransferase 7B [Homo sapiens]
Length = 374
Score = 73.2 bits (178), Expect = 3e-13
Identities = 63/267 (23%), Positives = 116/267 (43%), Gaps = 22/267 (8%)
Query: 78 SAYELPYGTKG-SEDLLLRVLAITSSS------IPKNIQSLRCRRCVVVGNGHRLRNSSL 130
S ++ PYG +G S ++ L++ + S P +C RC VVGNG L S
Sbjct: 106 SQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQ 165
Query: 131 GDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFD---------PKVENNPDT 181
G I+ +D V RLN A + G+E DVG+KT+ F + V D
Sbjct: 166 GPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDL 225
Query: 182 LLVLVAFKAMDFHWIETILSD---KKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAAD 238
+ + D+ + + + + + KG + + + ++L+P F+ +
Sbjct: 226 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTE 285
Query: 239 KLLSLPMQQPR-KIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITL 297
+ L + P+TG L + ALH CD ++ +G+ + K + HY+E+
Sbjct: 286 RFLKSKLINTHFGDLYMPSTGALMLLTALHTCD--QVSAYGFITSNYWKFSDHYFERKMK 343
Query: 298 KSMAGSGHNVSQEALAIKRMLEMGAIK 324
+ + H++S EA + + + G ++
Sbjct: 344 PLIFYANHDLSLEAALWRDLHKAGILQ 370
>gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform a [Homo sapiens]
Length = 529
Score = 71.2 bits (173), Expect = 1e-12
Identities = 72/268 (26%), Positives = 123/268 (45%), Gaps = 50/268 (18%)
Query: 74 VKTPSAYELPYGTKGSEDLLLRVLAITSSSI-PKNIQSLRCRRCVVVGNGHRLRNSSLGD 132
V+T E P+ G L V A+ S + P+ ++S C VV + + NSSLG+
Sbjct: 261 VRTLDGTEAPFSALGWRRL---VPAVPLSQLHPRGLRS-----CAVVMSAGAILNSSLGE 312
Query: 133 AINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPE-----SAHFDPKVENNPDTLLVLVA 187
I+ +D V+R N+AP GYE DVG+KTT+R+ + S HF ++++ ++LVA
Sbjct: 313 EIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHF---IDSSLYKDVILVA 369
Query: 188 -------------FKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFME 234
+K D++ + ++R QP + ++PK I L E
Sbjct: 370 WDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNP----NQP--FYILHPKFIWQLWDIIQE 423
Query: 235 IAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYE- 293
+K+ P P++G + I + + +C VH+ + Y + + + HY+E
Sbjct: 424 NTKEKIQPNP----------PSSGFIGILIMMSMCREVHV--YEYIPSVRQTELCHYHEL 471
Query: 294 QITLKSMAGSGHNVSQEALAIKRMLEMG 321
G+ H + E L ++R L MG
Sbjct: 472 YYDAACTLGAYHPLLYEKLLVQR-LNMG 498
>gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform a [Homo sapiens]
Length = 529
Score = 71.2 bits (173), Expect = 1e-12
Identities = 72/268 (26%), Positives = 123/268 (45%), Gaps = 50/268 (18%)
Query: 74 VKTPSAYELPYGTKGSEDLLLRVLAITSSSI-PKNIQSLRCRRCVVVGNGHRLRNSSLGD 132
V+T E P+ G L V A+ S + P+ ++S C VV + + NSSLG+
Sbjct: 261 VRTLDGTEAPFSALGWRRL---VPAVPLSQLHPRGLRS-----CAVVMSAGAILNSSLGE 312
Query: 133 AINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPE-----SAHFDPKVENNPDTLLVLVA 187
I+ +D V+R N+AP GYE DVG+KTT+R+ + S HF ++++ ++LVA
Sbjct: 313 EIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHF---IDSSLYKDVILVA 369
Query: 188 -------------FKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFME 234
+K D++ + ++R QP + ++PK I L E
Sbjct: 370 WDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNP----NQP--FYILHPKFIWQLWDIIQE 423
Query: 235 IAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYE- 293
+K+ P P++G + I + + +C VH+ + Y + + + HY+E
Sbjct: 424 NTKEKIQPNP----------PSSGFIGILIMMSMCREVHV--YEYIPSVRQTELCHYHEL 471
Query: 294 QITLKSMAGSGHNVSQEALAIKRMLEMG 321
G+ H + E L ++R L MG
Sbjct: 472 YYDAACTLGAYHPLLYEKLLVQR-LNMG 498
>gi|5031999 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 4 isoform a [Homo sapiens]
Length = 359
Score = 68.6 bits (166), Expect = 7e-12
Identities = 64/228 (28%), Positives = 104/228 (45%), Gaps = 16/228 (7%)
Query: 108 IQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKT---TMRLF 164
+++ R + C VVGN L +S G I+ ++ VIR N APV + DVG+K+ TM
Sbjct: 134 MKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPS 193
Query: 165 YPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL--SDKKRVRKGFWKQPPLIWDVNP 222
+ A + E++ + + ++ WI + +K V W ++ N
Sbjct: 194 VVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVE---WVNALIL--KNK 248
Query: 223 KQIRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGF-GYP- 280
++R P I A + L + P K +P+TGLL TLA CD +H+ GF +P
Sbjct: 249 LKVRTAYPSLRLIHAVRGYWLTNKVPIK---RPSTGLLMYTLATRFCDEIHLYGFWPFPK 305
Query: 281 DAYNKKQTIHYYEQITLKSMA-GSGHNVSQEALAIKRMLEMGAIKNLT 327
D K HYY+ + + + S H + E + + GA+K T
Sbjct: 306 DLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 353
>gi|5174677 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 2 [Homo sapiens]
Length = 375
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/216 (29%), Positives = 94/216 (43%), Gaps = 14/216 (6%)
Query: 116 CVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYP---ESAHFD 172
C +VGN L NS G I+ + VIR N APV Y DVG KT + P + A D
Sbjct: 157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFED 216
Query: 173 PKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFF 232
+ LL + WI ++ + R + + L VN +R P
Sbjct: 217 LVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVN---VRTAYPSL 273
Query: 233 MEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQT---I 289
+ A + L + K +PTTGLL TLA C +++ GF +P ++ Q
Sbjct: 274 RLLHAVRGYWLTNKVHIK---RPTTGLLMYTLATRFCKQIYLYGF-WPFPLDQNQNPVKY 329
Query: 290 HYYEQITL-KSMAGSGHNVSQEALAIKRMLEMGAIK 324
HYY+ + + S H + E A+K + E GA+K
Sbjct: 330 HYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALK 365
>gi|21361444 sialytransferase 7F [Homo sapiens]
Length = 333
Score = 62.8 bits (151), Expect = 4e-10
Identities = 58/217 (26%), Positives = 94/217 (43%), Gaps = 31/217 (14%)
Query: 94 LRVLAITSSSIP----KNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVA 149
L+ +IT +P K + S RC +CV+V + L + LG I + + IR+N+AP
Sbjct: 83 LKKWSITDGYVPILGNKTLPS-RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTT 141
Query: 150 GYEGDVGSKTTMRLFYPESA-----HFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKK 204
GY DVG+KTT R+ S V P+T+ + + ++
Sbjct: 142 GYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWGPPSK----MQKPQGSLV 197
Query: 205 RV--RKGFWKQPPLIWDVNPKQIRILNPFFM-EIAADKLLSLPMQQPRKIKQKPTTGLLA 261
RV R G + V+P ++R + F E D+ K +TG
Sbjct: 198 RVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDR---------EKSHSWLSTGWFT 248
Query: 262 ITLALHLCDLVHIAGFGYPDAYNKKQTI-----HYYE 293
+ +A+ LCD VH+ G P+ +++ + HYYE
Sbjct: 249 MVIAVELCDHVHVYGMVPPNYCSQRPRLQRMPYHYYE 285
>gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
isoform a [Homo sapiens]
Length = 406
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/190 (25%), Positives = 91/190 (47%), Gaps = 24/190 (12%)
Query: 115 RCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPK 174
RC VV + L++S LG I+ +D V+R N AP A ++ DVG+KTT+RL + + +
Sbjct: 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKR 242
Query: 175 -VENNPDTLLVLVAFKAMDFH-----WIE----TILSDKKRVRKGFWKQPPLIWDVNPKQ 224
++++ +L+ + +H W + ++ K RK QP + + P+
Sbjct: 243 FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQP--FYILKPQM 300
Query: 225 IRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYN 284
L EI+ +++ P P++G+L I + + LCD V I + + +
Sbjct: 301 PWELWDILQEISPEEIQPNP----------PSSGMLGIIIMMTLCDQVDI--YEFLPSKR 348
Query: 285 KKQTIHYYEQ 294
K +YY++
Sbjct: 349 KTDVCYYYQK 358
>gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
isoform a [Homo sapiens]
Length = 406
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/190 (25%), Positives = 91/190 (47%), Gaps = 24/190 (12%)
Query: 115 RCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPK 174
RC VV + L++S LG I+ +D V+R N AP A ++ DVG+KTT+RL + + +
Sbjct: 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKR 242
Query: 175 -VENNPDTLLVLVAFKAMDFH-----WIE----TILSDKKRVRKGFWKQPPLIWDVNPKQ 224
++++ +L+ + +H W + ++ K RK QP + + P+
Sbjct: 243 FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQP--FYILKPQM 300
Query: 225 IRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYN 284
L EI+ +++ P P++G+L I + + LCD V I + + +
Sbjct: 301 PWELWDILQEISPEEIQPNP----------PSSGMLGIIIMMTLCDQVDI--YEFLPSKR 348
Query: 285 KKQTIHYYEQ 294
K +YY++
Sbjct: 349 KTDVCYYYQK 358
>gi|13569938 sialyltransferase 7E [Homo sapiens]
Length = 336
Score = 62.0 bits (149), Expect = 7e-10
Identities = 54/189 (28%), Positives = 88/189 (46%), Gaps = 12/189 (6%)
Query: 111 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAH 170
+ CR C +V + L +S G I++ + VIR+N+AP GY DVG++T++R+ S
Sbjct: 91 MHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSS-- 148
Query: 171 FDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKG-FWKQPPLIWDVNPKQIRILN 229
+ N D L+ V+ + W + S +R KG + L+ V P+ +
Sbjct: 149 IQRILRNRHD--LLNVSQGTVFIFWGPS--SYMRRDGKGQVYNNLHLLSQVLPRLKAFMI 204
Query: 230 PFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLCDLVHIAGFGYP----DAYN 284
+ D+L + RKI +TG +T+AL LCD +++ G P D +
Sbjct: 205 TRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCRDPNH 264
Query: 285 KKQTIHYYE 293
HYYE
Sbjct: 265 PSVPYHYYE 273
>gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform b [Homo sapiens]
Length = 466
Score = 59.3 bits (142), Expect = 5e-09
Identities = 36/91 (39%), Positives = 53/91 (58%), Gaps = 9/91 (9%)
Query: 74 VKTPSAYELPYGTKGSEDLLLRVLAITSSSI-PKNIQSLRCRRCVVVGNGHRLRNSSLGD 132
V+T E P+ G L V A+ S + P+ ++S C VV + + NSSLG+
Sbjct: 261 VRTLDGTEAPFSALGWRRL---VPAVPLSQLHPRGLRS-----CAVVMSAGAILNSSLGE 312
Query: 133 AINKYDVVIRLNNAPVAGYEGDVGSKTTMRL 163
I+ +D V+R N+AP GYE DVG+KTT+R+
Sbjct: 313 EIDSHDAVLRFNSAPTRGYEKDVGNKTTIRI 343
>gi|110815855 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 3 [Homo sapiens]
Length = 380
Score = 58.9 bits (141), Expect = 6e-09
Identities = 57/196 (29%), Positives = 78/196 (39%), Gaps = 33/196 (16%)
Query: 116 CVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKV 175
C VVGN L S G I+K D V R N AP ++ DVG KT + F P K
Sbjct: 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILE---KY 218
Query: 176 ENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEI 235
NN T+ F LS KK W P + + R L FF+E
Sbjct: 219 YNNLLTIQDRNNF----------FLSLKKLDGAILW-IPAFFFHTSATVTRTLVDFFVEH 267
Query: 236 AADKLLSLPMQQPRKIKQ--------------KPTTGLLAITLALHLCDLVHIAG---FG 278
L + + P I Q + +TG+L TLA +C+ +H+ G FG
Sbjct: 268 RGQ--LKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFG 325
Query: 279 YPDAYNKKQTIHYYEQ 294
+ + HYY++
Sbjct: 326 FDPNTREDLPYHYYDK 341
>gi|28373101 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 5 [Homo sapiens]
Length = 376
Score = 55.1 bits (131), Expect = 9e-08
Identities = 54/208 (25%), Positives = 96/208 (46%), Gaps = 34/208 (16%)
Query: 105 PKNIQSLRC--RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVA-GYEGDVGSKTTM 161
PK++ R ++C VVGNG L+NS G IN D V R N P++ Y DVG KT +
Sbjct: 151 PKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDV 210
Query: 162 RLFYP----ESAH--------FDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKG 209
P E H F ++ + ++L AF ++ T +S + +
Sbjct: 211 VTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAF----YNTRNTDVSIRVKYVLD 266
Query: 210 FWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLC 269
++ P ++ +P+ + ++ +++ + ++ +TGL+ +T AL LC
Sbjct: 267 DFESPQAVYYFHPQYLVNVSRYWLSLGVR-------------AKRISTGLILVTAALELC 313
Query: 270 DLVHIAGF-GYP-DAYNKKQTIHYYEQI 295
+ VH+ GF +P + T HYY+ +
Sbjct: 314 EEVHLFGFWAFPMNPSGLYITHHYYDNV 341
>gi|229892273 sialyltransferase 7C isoform 1 [Homo sapiens]
Length = 305
Score = 52.4 bits (124), Expect = 6e-07
Identities = 53/197 (26%), Positives = 83/197 (42%), Gaps = 26/197 (13%)
Query: 111 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAH 170
L C C +V N ++ +G+ I++ + R+NNAP GYE DVG T +R+ S
Sbjct: 75 LDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSV- 133
Query: 171 FDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNP 230
P + NPD FK + I I + +RK +++++ K + I
Sbjct: 134 --PLLLKNPDYF-----FKEAN-TTIYVIWGPFRNMRK---DGNGIVYNMLKKTVGIYPN 182
Query: 231 FFMEIAADKLLSLPMQQPRKIKQKP--------TTGLLAITLALHLCDLVHIAGFGYPDA 282
+ + +K +S +K K +TG LA+ C +H+ G D
Sbjct: 183 AQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGM-INDT 241
Query: 283 YNK-----KQTIHYYEQ 294
Y K K HYYEQ
Sbjct: 242 YCKTEGYRKVPYHYYEQ 258
>gi|28373092 sialyltransferase 7D isoform a [Homo sapiens]
Length = 302
Score = 52.0 bits (123), Expect = 7e-07
Identities = 25/64 (39%), Positives = 38/64 (59%), Gaps = 2/64 (3%)
Query: 102 SSIPKNIQSLR--CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKT 159
SS+P +R CR C VV + ++ S LG I+ + V R+N AP G+E DVG ++
Sbjct: 60 SSVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRS 119
Query: 160 TMRL 163
T+R+
Sbjct: 120 TLRV 123
>gi|229892275 sialyltransferase 7C isoform 2 [Homo sapiens]
Length = 210
Score = 48.5 bits (114), Expect = 8e-06
Identities = 25/70 (35%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 111 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAH 170
L C C +V N ++ +G+ I++ + R+NNAP GYE DVG T +R+ S
Sbjct: 75 LDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSV- 133
Query: 171 FDPKVENNPD 180
P + NPD
Sbjct: 134 --PLLLKNPD 141
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,333,738
Number of Sequences: 37866
Number of extensions: 536659
Number of successful extensions: 1012
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 910
Number of HSP's gapped (non-prelim): 50
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.