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Search of human proteins with 5031975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
(591 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 1194 0.0
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 1194 0.0
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 1194 0.0
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 746 0.0
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 746 0.0
gi|191252782 p21-activated kinase 6 [Homo sapiens] 548 e-156
gi|191252780 p21-activated kinase 6 [Homo sapiens] 548 e-156
gi|9910476 p21-activated kinase 6 [Homo sapiens] 548 e-156
gi|29826329 p21-activated kinase 7 [Homo sapiens] 522 e-148
gi|24308191 p21-activated kinase 7 [Homo sapiens] 522 e-148
gi|32483399 p21-activated kinase 2 [Homo sapiens] 322 8e-88
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 319 4e-87
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 319 4e-87
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 319 4e-87
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 319 4e-87
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 319 4e-87
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 319 4e-87
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 314 1e-85
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 300 3e-81
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 200 3e-51
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 199 5e-51
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 192 7e-49
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 189 5e-48
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 189 5e-48
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 189 6e-48
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 187 2e-47
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 187 2e-47
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 186 4e-47
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 186 5e-47
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 186 5e-47
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 1194 bits (3090), Expect = 0.0
Identities = 591/591 (100%), Positives = 591/591 (100%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
Sbjct: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
Query: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
Sbjct: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
Query: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
Sbjct: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
Query: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
Sbjct: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
Query: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
Sbjct: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
Query: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
Sbjct: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
Query: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
Sbjct: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
Query: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
Sbjct: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Sbjct: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 1194 bits (3090), Expect = 0.0
Identities = 591/591 (100%), Positives = 591/591 (100%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
Sbjct: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
Query: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
Sbjct: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
Query: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
Sbjct: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
Query: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
Sbjct: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
Query: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
Sbjct: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
Query: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
Sbjct: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
Query: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
Sbjct: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
Query: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
Sbjct: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Sbjct: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 1194 bits (3090), Expect = 0.0
Identities = 591/591 (100%), Positives = 591/591 (100%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
Sbjct: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
Query: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
Sbjct: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
Query: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
Sbjct: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
Query: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
Sbjct: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
Query: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
Sbjct: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
Query: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
Sbjct: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
Query: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
Sbjct: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
Query: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
Sbjct: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Sbjct: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 746 bits (1925), Expect = 0.0
Identities = 370/371 (99%), Positives = 371/371 (100%)
Query: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
+GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 68 KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127
Query: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
Query: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
Query: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
Query: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
Query: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
Query: 581 IVPLMRQNRTR 591
IVPLMRQNRTR
Sbjct: 428 IVPLMRQNRTR 438
Score = 145 bits (366), Expect = 1e-34
Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
SIQPGAPK G G L + + S +R + R +P P A +
Sbjct: 61 SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117
Query: 116 GMPEEPATTARGGPGKAGSR 135
P A PG G R
Sbjct: 118 LAPPACTPAAPAVPGPPGPR 137
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 746 bits (1925), Expect = 0.0
Identities = 370/371 (99%), Positives = 371/371 (100%)
Query: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
+GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 68 KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127
Query: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
Query: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
Query: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
Query: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
Query: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
Query: 581 IVPLMRQNRTR 591
IVPLMRQNRTR
Sbjct: 428 IVPLMRQNRTR 438
Score = 145 bits (366), Expect = 1e-34
Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
SIQPGAPK G G L + + S +R + R +P P A +
Sbjct: 61 SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117
Query: 116 GMPEEPATTARGGPGKAGSR 135
P A PG G R
Sbjct: 118 LAPPACTPAAPAVPGPPGPR 137
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 548 bits (1411), Expect = e-156
Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63
Query: 64 PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
KT+VRGS DG ++ LL++ + +SV SN+LR SP RA+ + +E
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
Query: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
T ++ R H GG+ + P P+S R S GP
Sbjct: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183
Query: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
E + P + P GT + A+ RP + + T P
Sbjct: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241
Query: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
G +G P AP S G +SS RPP
Sbjct: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301
Query: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
+A+ PS G P + +P APA PG SP P+
Sbjct: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361
Query: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
V+HEQF+AAL++VVD GDPR LD+++KIGEGSTGIV
Sbjct: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421
Query: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
C+A + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481
Query: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
EFL+GGALTDIV+ R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541
Query: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR Y EVDIWSLGIMVIEMVDGEPPY
Sbjct: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601
Query: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL +
Sbjct: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661
Query: 576 GPPASIVPLMRQNR 589
G P +VPL++ R
Sbjct: 662 GLPECLVPLIQLYR 675
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 548 bits (1411), Expect = e-156
Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63
Query: 64 PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
KT+VRGS DG ++ LL++ + +SV SN+LR SP RA+ + +E
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
Query: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
T ++ R H GG+ + P P+S R S GP
Sbjct: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183
Query: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
E + P + P GT + A+ RP + + T P
Sbjct: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241
Query: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
G +G P AP S G +SS RPP
Sbjct: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301
Query: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
+A+ PS G P + +P APA PG SP P+
Sbjct: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361
Query: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
V+HEQF+AAL++VVD GDPR LD+++KIGEGSTGIV
Sbjct: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421
Query: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
C+A + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481
Query: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
EFL+GGALTDIV+ R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541
Query: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR Y EVDIWSLGIMVIEMVDGEPPY
Sbjct: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601
Query: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL +
Sbjct: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661
Query: 576 GPPASIVPLMRQNR 589
G P +VPL++ R
Sbjct: 662 GLPECLVPLIQLYR 675
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 548 bits (1411), Expect = e-156
Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
K+KKR EISAP NF+HRVHT FD E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63
Query: 64 PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
KT+VRGS DG ++ LL++ + +SV SN+LR SP RA+ + +E
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123
Query: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
T ++ R H GG+ + P P+S R S GP
Sbjct: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183
Query: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
E + P + P GT + A+ RP + + T P
Sbjct: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241
Query: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
G +G P AP S G +SS RPP
Sbjct: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301
Query: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
+A+ PS G P + +P APA PG SP P+
Sbjct: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361
Query: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
V+HEQF+AAL++VVD GDPR LD+++KIGEGSTGIV
Sbjct: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421
Query: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
C+A + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481
Query: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
EFL+GGALTDIV+ R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541
Query: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR Y EVDIWSLGIMVIEMVDGEPPY
Sbjct: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601
Query: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL +
Sbjct: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661
Query: 576 GPPASIVPLMRQNR 589
G P +VPL++ R
Sbjct: 662 GLPECLVPLIQLYR 675
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 522 bits (1344), Expect = e-148
Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)
Query: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
++RPKSS PQ + R +R SG + P P G ++ G +N+Y
Sbjct: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
Query: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
P+ D D P G+ D P GP+ +PQS SSSS + P
Sbjct: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
Query: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
+ A PS + S + + ++ P P S ++P RVSHEQFR
Sbjct: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
Query: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
Query: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
Query: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS L
Sbjct: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
Query: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVPLMRQ R
Sbjct: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
Score = 160 bits (405), Expect = 3e-39
Identities = 73/116 (62%), Positives = 94/116 (81%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
Query: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
IQ KTIVRG+K K+ ++ LL++F+N+SVTRSNSLR++SPP P + +G
Sbjct: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 522 bits (1344), Expect = e-148
Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)
Query: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
++RPKSS PQ + R +R SG + P P G ++ G +N+Y
Sbjct: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
Query: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
P+ D D P G+ D P GP+ +PQS SSSS + P
Sbjct: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
Query: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
+ A PS + S + + ++ P P S ++P RVSHEQFR
Sbjct: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
Query: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
Query: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
Query: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS L
Sbjct: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
Query: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVPLMRQ R
Sbjct: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
Score = 160 bits (405), Expect = 3e-39
Identities = 73/116 (62%), Positives = 94/116 (81%)
Query: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
Query: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
IQ KTIVRG+K K+ ++ LL++F+N+SVTRSNSLR++SPP P + +G
Sbjct: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 322 bits (824), Expect = 8e-88
Identities = 167/362 (46%), Positives = 236/362 (65%), Gaps = 22/362 (6%)
Query: 246 SSRPPTRARGAPSPGVLGPHASEPQ-LAPPACTP------------AAPAVPGPPGPR-- 290
S P A+G +P V+ + + APP P VP P G
Sbjct: 152 SGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHV 211
Query: 291 -------SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 343
Q++ +++ E+ L+ +V GDP+ + KIG+G++G V AT +
Sbjct: 212 DGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVAL 271
Query: 344 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 403
G+ VA+K+++L+KQ ++EL+ NE+++M++ ++ N+V +SYLVGDEL+VVME+L GG+L
Sbjct: 272 GQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSL 331
Query: 404 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 463
TD+VT T M+E QIAAVC LQAL LHA VIHRDIKSD++LL +G VKL+DFGFCA
Sbjct: 332 TDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCA 391
Query: 464 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 523
Q++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE PL+A
Sbjct: 392 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 451
Query: 524 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 583
+ +I N P L+N K+SP + FL+R L D +R +A ELL+HPFL A P +S+ P
Sbjct: 452 LYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTP 511
Query: 584 LM 585
L+
Sbjct: 512 LI 513
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 67 KEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 109
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
A P S+ ++S PP + + PP P A+
Sbjct: 168 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 227
Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 228 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 287
Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 347
Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 348 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407
Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 408 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467
Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 468 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 527
Query: 566 LLKHPFLAKAGPPASIVPLM 585
LL+HPFL A P +S+ PL+
Sbjct: 528 LLQHPFLKLAKPLSSLTPLI 547
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 15/58 (25%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FT G+P QW L++ S
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
A P S+ ++S PP + + PP P A+
Sbjct: 174 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 233
Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 234 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 293
Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 294 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 353
Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 354 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 413
Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 414 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 473
Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 474 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 533
Query: 566 LLKHPFLAKAGPPASIVPLM 585
LL+HPFL A P +S+ PL+
Sbjct: 534 LLQHPFLKLAKPLSSLTPLI 553
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 21/64 (32%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
Query: 43 IEES 46
++ S
Sbjct: 123 LQTS 126
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
A P S+ ++S PP + + PP P A+
Sbjct: 189 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 248
Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 249 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 308
Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 309 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 368
Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 369 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 428
Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 429 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 488
Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 489 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 548
Query: 566 LLKHPFLAKAGPPASIVPLM 585
LL+HPFL A P +S+ PL+
Sbjct: 549 LLQHPFLKLAKPLSSLTPLI 568
Score = 42.0 bits (97), Expect = 0.002
Identities = 19/35 (54%), Positives = 23/35 (65%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQ 38
K K+R EIS PS+FEH +H GFD +FT P Q
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
A P S+ ++S PP + + PP P A+
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 212
Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 213 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 272
Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 273 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 332
Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 333 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392
Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 393 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452
Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 512
Query: 566 LLKHPFLAKAGPPASIVPLM 585
LL+HPFL A P +S+ PL+
Sbjct: 513 LLQHPFLKLAKPLSSLTPLI 532
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTS 105
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
A P S+ ++S PP + + PP P A+
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 212
Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 213 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 272
Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 273 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 332
Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 333 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392
Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 393 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452
Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 512
Query: 566 LLKHPFLAKAGPPASIVPLM 585
LL+HPFL A P +S+ PL+
Sbjct: 513 LLQHPFLKLAKPLSSLTPLI 532
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTS 105
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
A P S+ ++S PP + + PP P A+
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 212
Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 213 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 272
Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 273 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 332
Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 333 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392
Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 393 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452
Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 512
Query: 566 LLKHPFLAKAGPPASIVPLM 585
LL+HPFL A P +S+ PL+
Sbjct: 513 LLQHPFLKLAKPLSSLTPLI 532
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTS 105
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 314 bits (805), Expect = 1e-85
Identities = 154/293 (52%), Positives = 215/293 (73%)
Query: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
Q++ ++S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M
Sbjct: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301
Query: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361
Query: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R
Sbjct: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421
Query: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
++VGTPYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N
Sbjct: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
Query: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 585
P L+N K+S + FL+R L D +R +A ELL+H FL A P +S+ PL+
Sbjct: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLI 534
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 300 bits (767), Expect = 3e-81
Identities = 146/276 (52%), Positives = 204/276 (73%)
Query: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
Q++ ++S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M
Sbjct: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301
Query: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361
Query: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R
Sbjct: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421
Query: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
++VGTPYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N
Sbjct: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
Query: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 568
P L+N K+S + FL+R L D +R +A ELL+
Sbjct: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 200 bits (509), Expect = 3e-51
Identities = 104/273 (38%), Positives = 163/273 (59%), Gaps = 4/273 (1%)
Query: 317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 376
P D K+GEGS G V A + SG++VA+K++ + + + E+ IM+
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSP 80
Query: 377 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAAVCLAVLQALSVLHAQ 434
VV+ Y SY +LW+VME+ G+++DI+ + + E++IA + + L+ L LH
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
IHRDIK+ +ILL +G KL+DFG Q++ + +R +++GTP+WMAPE+I + Y
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 200
Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
DIWSLGI IEM +G+PPY + P++A+ MI N PP + S F+ + LV
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 260
Query: 555 RDPAQRATAAELLKHPFLAKAGPPASIVPLMRQ 587
++P QRATA +LL+HPF+ A P + + L+ +
Sbjct: 261 KNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 199 bits (507), Expect = 5e-51
Identities = 101/261 (38%), Positives = 158/261 (60%), Gaps = 4/261 (1%)
Query: 317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 376
P D K+GEGS G V A + +G++VA+K++ + + + E+ IM+
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--IIKEISIMQQCDSP 83
Query: 377 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAAVCLAVLQALSVLHAQ 434
+VV+ Y SY +LW+VME+ G+++DI+ + + E++IA + + L+ L LH
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
IHRDIK+ +ILL +G KL+DFG Q++ + +R +++GTP+WMAPE+I + Y
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203
Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
DIWSLGI IEM +G+PPY + P++A+ MI N PP + S + F+ + LV
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263
Query: 555 RDPAQRATAAELLKHPFLAKA 575
+ P QRATA +LL+HPF+ A
Sbjct: 264 KSPEQRATATQLLQHPFVRSA 284
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 192 bits (488), Expect = 7e-49
Identities = 106/265 (40%), Positives = 166/265 (62%), Gaps = 6/265 (2%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
+P+ + +IG G+ G V A ++G+L A+K + L + ++ E+++M+D +H
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 376 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 434
N+V + SYL D+LW+ MEF GG+L DI T ++E QIA V LQ L LH++
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLP 491
G +HRDIK +ILLT +G VKL+DFG AQ++ + +RKS +GTPYWMAPE+ + +
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 492 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAM-KMIRDNL-PPRLKNLHKVSPSLKGFL 549
Y D+W++GI IE+ + +PP F+ P++A+ M + N PP+LK+ K S S F+
Sbjct: 191 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 250
Query: 550 DRLLVRDPAQRATAAELLKHPFLAK 574
L ++P +R TA +LL+HPF+ +
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQ 275
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 189 bits (481), Expect = 5e-48
Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
DP KIG+GS G V + K+VA+K +DL + + E + E+ ++
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 434
V + Y SYL +LW++ME+L GG+ D++ ++E QIA + +L+ L LH++
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
IHRDIK+ ++LL+ G VKL+DFG Q++ +R + VGTP+WMAPE+I + Y
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
+ DIWSLGI IE+ GEPP+ P+K + +I N PP L+ S LK F++ L
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256
Query: 555 RDPAQRATAAELLKHPFLAK 574
++P+ R TA ELLKH F+ +
Sbjct: 257 KEPSFRPTAKELLKHKFILR 276
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 189 bits (481), Expect = 5e-48
Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
DP KIG+GS G V + K+VA+K +DL + + E + E+ ++
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 434
V + Y SYL +LW++ME+L GG+ D++ ++E QIA + +L+ L LH++
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 150
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
IHRDIK+ ++LL+ G VKL+DFG Q++ +R + VGTP+WMAPE+I + Y
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210
Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
+ DIWSLGI IE+ GEPP+ P+K + +I N PP L+ S LK F++ L
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 268
Query: 555 RDPAQRATAAELLKHPFLAK 574
++P+ R TA ELLKH F+ +
Sbjct: 269 KEPSFRPTAKELLKHKFILR 288
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 189 bits (480), Expect = 6e-48
Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
DP +IG+GS G V + ++VA+K +DL + + E + E+ ++
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 434
V + Y SYL G +LW++ME+L GG+ D++ +E QIA + +L+ L LH++
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 138
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
IHRDIK+ ++LL+ G VKL+DFG Q++ +R + VGTP+WMAPE+I + Y
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198
Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
+ DIWSLGI IE+ GEPP + P++ + +I N PP L + + S K F+D L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL--VGDFTKSFKEFIDACLN 256
Query: 555 RDPAQRATAAELLKHPFLAK 574
+DP+ R TA ELLKH F+ K
Sbjct: 257 KDPSFRPTAKELLKHKFIVK 276
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 187 bits (475), Expect = 2e-47
Identities = 108/276 (39%), Positives = 160/276 (57%), Gaps = 10/276 (3%)
Query: 311 VVDPG----DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 366
VVDP DPR + D ++G G+ G V A + SG LVA+K + + L E
Sbjct: 3 VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE 62
Query: 367 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 425
++I++ +H N+V + SYL +LW+ MEF G+L DI T ++E QI+ VC VL
Sbjct: 63 ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL 122
Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
Q L+ LH+Q IHRDIK +IL+ G V+L+DFG AQ+ + RR S +GTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 486 LIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHK 540
+ + + Y DIWSLGI IE+ + +PP F+ PL+ + ++ + PPRLK K
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 576
S + F+ L + P +R +A ++L H +++ G
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPG 278
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 187 bits (475), Expect = 2e-47
Identities = 108/276 (39%), Positives = 160/276 (57%), Gaps = 10/276 (3%)
Query: 311 VVDPG----DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 366
VVDP DPR + D ++G G+ G V A + SG LVA+K + + L E
Sbjct: 3 VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE 62
Query: 367 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 425
++I++ +H N+V + SYL +LW+ MEF G+L DI T ++E QI+ VC VL
Sbjct: 63 ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL 122
Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
Q L+ LH+Q IHRDIK +IL+ G V+L+DFG AQ+ + RR S +GTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 486 LIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHK 540
+ + + Y DIWSLGI IE+ + +PP F+ PL+ + ++ + PPRLK K
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 576
S + F+ L + P +R +A ++L H +++ G
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPG 278
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 186 bits (473), Expect = 4e-47
Identities = 106/276 (38%), Positives = 161/276 (58%), Gaps = 6/276 (2%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
DPR + ++G G+ G V A + +L AVK + L L E+ I+R+ +H
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70
Query: 376 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 434
NVV SYL D LW+ MEF GG+L +I T + E QIA VC L+ L LH+Q
Sbjct: 71 PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQ 130
Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLP 491
G IHRDIK ++LLT G VKL+DFG +++ V +R+S +GTPYWMAPE+ + +
Sbjct: 131 GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGG 190
Query: 492 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHKVSPSLKGFL 549
Y D+W+LGI IE+ + +PP F+ P++A+ ++ + PP+L++ + + + FL
Sbjct: 191 YNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFL 250
Query: 550 DRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 585
L ++P +R TA +LL+HPF + P A + L+
Sbjct: 251 KLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLL 286
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 186 bits (472), Expect = 5e-47
Identities = 104/272 (38%), Positives = 160/272 (58%), Gaps = 17/272 (6%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
DP + +G G+ G V +G+L A+K MD+ + E+ E+ +++ Y H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSH 78
Query: 376 E-NVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIAAVCLAVL 425
N+ Y +++ + D+LW+VMEF G++TD++ +T+ N EE IA +C +L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
+ LS LH VIHRDIK ++LLT + VKL DFG AQ+ + V RR + +GTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 486 LIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
+I+ Y + D+WSLGI IEM +G PP + P++A+ +I N PRLK+ K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
S + F++ LV++ +QR +L+KHPF+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
Score = 33.5 bits (75), Expect = 0.56
Identities = 35/138 (25%), Positives = 49/138 (35%), Gaps = 15/138 (10%)
Query: 96 RSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAG 155
RS+ LR++ PP ++ + PA + PG + G G + D RR
Sbjct: 574 RSSWLRQEEDIPPKVPQRTTSI--SPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631
Query: 156 PEKRPKSSREGSGGPQESSRDKRPLSGP-DVGTPQPAGLASGAKLAAGRPFNTYPRADTD 214
P R SG SS P S P G QP A ++ R +
Sbjct: 632 PILESPLQRTSSG---SSSSSSTPSSQPSSQGGSQPGSQAGSSERT---------RVRAN 679
Query: 215 HPSRGAQGEPHDVAPNGP 232
S G+ PH+ A P
Sbjct: 680 SKSEGSPVLPHEPAKVKP 697
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 186 bits (472), Expect = 5e-47
Identities = 104/272 (38%), Positives = 160/272 (58%), Gaps = 17/272 (6%)
Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
DP + +G G+ G V +G+L A+K MD+ + E+ E+ +++ Y H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSH 78
Query: 376 E-NVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIAAVCLAVL 425
N+ Y +++ + D+LW+VMEF G++TD++ +T+ N EE IA +C +L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
+ LS LH VIHRDIK ++LLT + VKL DFG AQ+ + V RR + +GTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 486 LIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
+I+ Y + D+WSLGI IEM +G PP + P++A+ +I N PRLK+ K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
S + F++ LV++ +QR +L+KHPF+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
Score = 33.5 bits (75), Expect = 0.56
Identities = 35/138 (25%), Positives = 49/138 (35%), Gaps = 15/138 (10%)
Query: 96 RSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAG 155
RS+ LR++ PP ++ + PA + PG + G G + D RR
Sbjct: 574 RSSWLRQEEDIPPKVPQRTTSI--SPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631
Query: 156 PEKRPKSSREGSGGPQESSRDKRPLSGP-DVGTPQPAGLASGAKLAAGRPFNTYPRADTD 214
P R SG SS P S P G QP A ++ R +
Sbjct: 632 PILESPLQRTSSG---SSSSSSTPSSQPSSQGGSQPGSQAGSSERT---------RVRAN 679
Query: 215 HPSRGAQGEPHDVAPNGP 232
S G+ PH+ A P
Sbjct: 680 SKSEGSPVLPHEPAKVKP 697
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,287,149
Number of Sequences: 37866
Number of extensions: 1824000
Number of successful extensions: 25229
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 868
Number of HSP's successfully gapped in prelim test: 1682
Number of HSP's that attempted gapping in prelim test: 12651
Number of HSP's gapped (non-prelim): 8517
length of query: 591
length of database: 18,247,518
effective HSP length: 108
effective length of query: 483
effective length of database: 14,157,990
effective search space: 6838309170
effective search space used: 6838309170
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.