Guide to the Human Genome
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Search of human proteins with 5031975

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
         (591 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]          1194   0.0  
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]          1194   0.0  
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]           1194   0.0  
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]           746   0.0  
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]           746   0.0  
gi|191252782 p21-activated kinase 6 [Homo sapiens]                    548   e-156
gi|191252780 p21-activated kinase 6 [Homo sapiens]                    548   e-156
gi|9910476 p21-activated kinase 6 [Homo sapiens]                      548   e-156
gi|29826329 p21-activated kinase 7 [Homo sapiens]                     522   e-148
gi|24308191 p21-activated kinase 7 [Homo sapiens]                     522   e-148
gi|32483399 p21-activated kinase 2 [Homo sapiens]                     322   8e-88
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]          319   4e-87
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]          319   4e-87
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]          319   4e-87
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]          319   4e-87
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]          319   4e-87
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]            319   4e-87
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]           314   1e-85
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]          300   3e-81
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 200   3e-51
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   199   5e-51
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   192   7e-49
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      189   5e-48
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       189   5e-48
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   189   6e-48
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   187   2e-47
gi|6005810 mitogen-activated protein kinase kinase kinase kinase...   187   2e-47
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   186   4e-47
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   186   5e-47
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...   186   5e-47

>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score = 1194 bits (3090), Expect = 0.0
 Identities = 591/591 (100%), Positives = 591/591 (100%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
           SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
Sbjct: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120

Query: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
           PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
Sbjct: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180

Query: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
           SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
Sbjct: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240

Query: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
           QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
Sbjct: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300

Query: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
           HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
Sbjct: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360

Query: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
           ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
Sbjct: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420

Query: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
           CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
Sbjct: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480

Query: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
           WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
Sbjct: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
           VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Sbjct: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591


>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score = 1194 bits (3090), Expect = 0.0
 Identities = 591/591 (100%), Positives = 591/591 (100%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
           SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
Sbjct: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120

Query: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
           PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
Sbjct: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180

Query: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
           SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
Sbjct: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240

Query: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
           QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
Sbjct: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300

Query: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
           HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
Sbjct: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360

Query: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
           ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
Sbjct: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420

Query: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
           CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
Sbjct: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480

Query: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
           WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
Sbjct: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
           VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Sbjct: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591


>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score = 1194 bits (3090), Expect = 0.0
 Identities = 591/591 (100%), Positives = 591/591 (100%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120
           SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
Sbjct: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE 120

Query: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180
           PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
Sbjct: 121 PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL 180

Query: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240
           SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
Sbjct: 181 SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP 240

Query: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300
           QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
Sbjct: 241 QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS 300

Query: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360
           HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
Sbjct: 301 HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR 360

Query: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420
           ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
Sbjct: 361 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 420

Query: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480
           CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
Sbjct: 421 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 480

Query: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
           WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
Sbjct: 481 WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
           VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Sbjct: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591


>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
          Length = 438

 Score =  746 bits (1925), Expect = 0.0
 Identities = 370/371 (99%), Positives = 371/371 (100%)

Query: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
           +GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 68  KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127

Query: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
           PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187

Query: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
           RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247

Query: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
           GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307

Query: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
           FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367

Query: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
           LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427

Query: 581 IVPLMRQNRTR 591
           IVPLMRQNRTR
Sbjct: 428 IVPLMRQNRTR 438



 Score =  145 bits (366), Expect = 1e-34
 Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
           SIQPGAPK         G   G L +      + S +R  +  R +P P      A +  
Sbjct: 61  SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117

Query: 116 GMPEEPATTARGGPGKAGSR 135
             P      A   PG  G R
Sbjct: 118 LAPPACTPAAPAVPGPPGPR 137


>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
          Length = 438

 Score =  746 bits (1925), Expect = 0.0
 Identities = 370/371 (99%), Positives = 371/371 (100%)

Query: 221 QGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 280
           +GEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA
Sbjct: 68  KGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA 127

Query: 281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 340
           PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV
Sbjct: 128 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187

Query: 341 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 400
           RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG
Sbjct: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247

Query: 401 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 460
           GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG
Sbjct: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307

Query: 461 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
           FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
Sbjct: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367

Query: 521 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
           LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS
Sbjct: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427

Query: 581 IVPLMRQNRTR 591
           IVPLMRQNRTR
Sbjct: 428 IVPLMRQNRTR 438



 Score =  145 bits (366), Expect = 1e-34
 Identities = 83/140 (59%), Positives = 89/140 (63%), Gaps = 8/140 (5%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  SIQPGAPKTIVR--GSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPA---RARQEN 115
           SIQPGAPK         G   G L +      + S +R  +  R +P P      A +  
Sbjct: 61  SIQPGAPKGEPHDVAPNGPSAGGLAI---PQSSSSSSRPPTRARGAPSPGVLGPHASEPQ 117

Query: 116 GMPEEPATTARGGPGKAGSR 135
             P      A   PG  G R
Sbjct: 118 LAPPACTPAAPAVPGPPGPR 137


>gi|191252782 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score =  548 bits (1411), Expect = e-156
 Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
           K+KKR EISAP NF+HRVHT FD  E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 5   KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63

Query: 64  PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
               KT+VRGS    DG ++ LL++ + +SV  SN+LR  SP    RA+    + +E   
Sbjct: 64  LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123

Query: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
           T      ++    R   H       GG+    +  P   P+S R           S GP 
Sbjct: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183

Query: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
           E               +   P + P  GT +    A+       RP +    + T  P  
Sbjct: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241

Query: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
           G +G P                        AP   S  G       +SS RPP       
Sbjct: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301

Query: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
              +A+  PS    G   P  +    +P      APA    PG  SP   P+        
Sbjct: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361

Query: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
                                  V+HEQF+AAL++VVD GDPR  LD+++KIGEGSTGIV
Sbjct: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421

Query: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
           C+A  + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481

Query: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
           EFL+GGALTDIV+  R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541

Query: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
           LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR  Y  EVDIWSLGIMVIEMVDGEPPY
Sbjct: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601

Query: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
           F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL + 
Sbjct: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661

Query: 576 GPPASIVPLMRQNR 589
           G P  +VPL++  R
Sbjct: 662 GLPECLVPLIQLYR 675


>gi|191252780 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score =  548 bits (1411), Expect = e-156
 Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
           K+KKR EISAP NF+HRVHT FD  E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 5   KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63

Query: 64  PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
               KT+VRGS    DG ++ LL++ + +SV  SN+LR  SP    RA+    + +E   
Sbjct: 64  LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123

Query: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
           T      ++    R   H       GG+    +  P   P+S R           S GP 
Sbjct: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183

Query: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
           E               +   P + P  GT +    A+       RP +    + T  P  
Sbjct: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241

Query: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
           G +G P                        AP   S  G       +SS RPP       
Sbjct: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301

Query: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
              +A+  PS    G   P  +    +P      APA    PG  SP   P+        
Sbjct: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361

Query: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
                                  V+HEQF+AAL++VVD GDPR  LD+++KIGEGSTGIV
Sbjct: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421

Query: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
           C+A  + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481

Query: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
           EFL+GGALTDIV+  R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541

Query: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
           LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR  Y  EVDIWSLGIMVIEMVDGEPPY
Sbjct: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601

Query: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
           F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL + 
Sbjct: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661

Query: 576 GPPASIVPLMRQNR 589
           G P  +VPL++  R
Sbjct: 662 GLPECLVPLIQLYR 675


>gi|9910476 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score =  548 bits (1411), Expect = e-156
 Identities = 327/674 (48%), Positives = 401/674 (59%), Gaps = 91/674 (13%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQ 63
           K+KKR EISAP NF+HRVHT FD  E KF GLP QWQ++++ + RRPKP+VDP+ IT +Q
Sbjct: 5   KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILD-TLRRPKPVVDPSRITRVQ 63

Query: 64  PGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPAT 123
               KT+VRGS    DG ++ LL++ + +SV  SN+LR  SP    RA+    + +E   
Sbjct: 64  LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWA 123

Query: 124 TARGGPGKAGSRGRFAGHS---EAGGGSGDRRRAGPEKRPKSSR---------EGSGGPQ 171
           T      ++    R   H       GG+    +  P   P+S R           S GP 
Sbjct: 124 TDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPA 183

Query: 172 ESS-------------RDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR 218
           E               +   P + P  GT +    A+       RP +    + T  P  
Sbjct: 184 EFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRP-- 241

Query: 219 GAQGEPHD---------------------VAPNGPSAGGLAIPQSSSSSSRPP------- 250
           G +G P                        AP   S  G       +SS RPP       
Sbjct: 242 GGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPS 301

Query: 251 --TRARGAPSP---GVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQR------- 298
              +A+  PS    G   P  +    +P      APA    PG  SP   P+        
Sbjct: 302 LVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIST 361

Query: 299 -----------------------VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
                                  V+HEQF+AAL++VVD GDPR  LD+++KIGEGSTGIV
Sbjct: 362 SNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIV 421

Query: 336 CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM 395
           C+A  + SG+ VAVK MDLRKQQRRELLFNEVVIMRDYQH NVVEMY SYLVG+ELWV+M
Sbjct: 422 CLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLM 481

Query: 396 EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 455
           EFL+GGALTDIV+  R+NEEQIA VC AVLQAL+ LHAQGVIHRDIKSDSILLT DGRVK
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVK 541

Query: 456 LSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
           LSDFGFCAQ+SK+VP+RKSLVGTPYWMAPE+ISR  Y  EVDIWSLGIMVIEMVDGEPPY
Sbjct: 542 LSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPY 601

Query: 516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 575
           F++ P++AMK +RD+ PP+LKN HKVSP L+ FL+R+LVRDP +RATA ELL HPFL + 
Sbjct: 602 FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 661

Query: 576 GPPASIVPLMRQNR 589
           G P  +VPL++  R
Sbjct: 662 GLPECLVPLIQLYR 675


>gi|29826329 p21-activated kinase 7 [Homo sapiens]
          Length = 719

 Score =  522 bits (1344), Expect = e-148
 Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)

Query: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
           ++RPKSS      PQ + R +R  SG  +  P  P G ++      G  +N+Y       
Sbjct: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323

Query: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
                P+ D D        P  G+     D  P GP+     +PQS      SSSS + P
Sbjct: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374

Query: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
           +    A     PS      + S       + + ++   P P    S  ++P RVSHEQFR
Sbjct: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433

Query: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
           AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493

Query: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
           EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553

Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
           +ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613

Query: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
           +ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS  L
Sbjct: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673

Query: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
           +GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVPLMRQ R
Sbjct: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717



 Score =  160 bits (405), Expect = 3e-39
 Identities = 73/116 (62%), Positives = 94/116 (81%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60

Query: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
            IQ    KTIVRG+K  K+ ++  LL++F+N+SVTRSNSLR++SPP P +    +G
Sbjct: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116


>gi|24308191 p21-activated kinase 7 [Homo sapiens]
          Length = 719

 Score =  522 bits (1344), Expect = e-148
 Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)

Query: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
           ++RPKSS      PQ + R +R  SG  +  P  P G ++      G  +N+Y       
Sbjct: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323

Query: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
                P+ D D        P  G+     D  P GP+     +PQS      SSSS + P
Sbjct: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374

Query: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
           +    A     PS      + S       + + ++   P P    S  ++P RVSHEQFR
Sbjct: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433

Query: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
           AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493

Query: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
           EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553

Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
           +ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613

Query: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
           +ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS  L
Sbjct: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673

Query: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
           +GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVPLMRQ R
Sbjct: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717



 Score =  160 bits (405), Expect = 3e-39
 Identities = 73/116 (62%), Positives = 94/116 (81%)

Query: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60

Query: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
            IQ    KTIVRG+K  K+ ++  LL++F+N+SVTRSNSLR++SPP P +    +G
Sbjct: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116


>gi|32483399 p21-activated kinase 2 [Homo sapiens]
          Length = 524

 Score =  322 bits (824), Expect = 8e-88
 Identities = 167/362 (46%), Positives = 236/362 (65%), Gaps = 22/362 (6%)

Query: 246 SSRPPTRARGAPSPGVLGPHASEPQ-LAPPACTP------------AAPAVPGPPGPR-- 290
           S  P   A+G  +P V+     + +  APP   P                VP P G    
Sbjct: 152 SGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHV 211

Query: 291 -------SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 343
                    Q++  +++ E+    L+ +V  GDP+     + KIG+G++G V  AT  + 
Sbjct: 212 DGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVAL 271

Query: 344 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 403
           G+ VA+K+++L+KQ ++EL+ NE+++M++ ++ N+V   +SYLVGDEL+VVME+L GG+L
Sbjct: 272 GQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSL 331

Query: 404 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 463
           TD+VT T M+E QIAAVC   LQAL  LHA  VIHRDIKSD++LL  +G VKL+DFGFCA
Sbjct: 332 TDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCA 391

Query: 464 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 523
           Q++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM IEMV+GEPPY NE PL+A
Sbjct: 392 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 451

Query: 524 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 583
           + +I  N  P L+N  K+SP  + FL+R L  D  +R +A ELL+HPFL  A P +S+ P
Sbjct: 452 LYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTP 511

Query: 584 LM 585
           L+
Sbjct: 512 LI 513



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 23/43 (53%), Positives = 30/43 (69%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FTG+P QW  L++ S
Sbjct: 67  KEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 109


>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
          Length = 559

 Score =  319 bits (818), Expect = 4e-87
 Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)

Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
           A P S+ ++S PP     +           +    PP   P                 A+
Sbjct: 168 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 227

Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
           PAVP     PP   +            QR+  +++ E+    L+ +V  GDP+     F 
Sbjct: 228 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 287

Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
           KIG+G++G V  A   ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V   +SY
Sbjct: 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 347

Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
           LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC   LQAL  LH+  VIHRDIKSD+
Sbjct: 348 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407

Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
           ILL  DG VKL+DFGFCAQ++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM 
Sbjct: 408 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467

Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
           IEMV+GEPPY NE PL+A+ +I  N  P L+N  ++S   + FL+R L  D  +R +A E
Sbjct: 468 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 527

Query: 566 LLKHPFLAKAGPPASIVPLM 585
           LL+HPFL  A P +S+ PL+
Sbjct: 528 LLQHPFLKLAKPLSSLTPLI 547



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 15/58 (25%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FT               G+P QW  L++ S
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120


>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
          Length = 565

 Score =  319 bits (818), Expect = 4e-87
 Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)

Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
           A P S+ ++S PP     +           +    PP   P                 A+
Sbjct: 174 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 233

Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
           PAVP     PP   +            QR+  +++ E+    L+ +V  GDP+     F 
Sbjct: 234 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 293

Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
           KIG+G++G V  A   ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V   +SY
Sbjct: 294 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 353

Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
           LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC   LQAL  LH+  VIHRDIKSD+
Sbjct: 354 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 413

Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
           ILL  DG VKL+DFGFCAQ++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM 
Sbjct: 414 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 473

Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
           IEMV+GEPPY NE PL+A+ +I  N  P L+N  ++S   + FL+R L  D  +R +A E
Sbjct: 474 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 533

Query: 566 LLKHPFLAKAGPPASIVPLM 585
           LL+HPFL  A P +S+ PL+
Sbjct: 534 LLQHPFLKLAKPLSSLTPLI 553



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 21/64 (32%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
           K K+R EIS PS+FEH +H GFD    +FT                     G+P QW  L
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122

Query: 43  IEES 46
           ++ S
Sbjct: 123 LQTS 126


>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
          Length = 580

 Score =  319 bits (818), Expect = 4e-87
 Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)

Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
           A P S+ ++S PP     +           +    PP   P                 A+
Sbjct: 189 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 248

Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
           PAVP     PP   +            QR+  +++ E+    L+ +V  GDP+     F 
Sbjct: 249 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 308

Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
           KIG+G++G V  A   ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V   +SY
Sbjct: 309 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 368

Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
           LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC   LQAL  LH+  VIHRDIKSD+
Sbjct: 369 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 428

Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
           ILL  DG VKL+DFGFCAQ++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM 
Sbjct: 429 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 488

Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
           IEMV+GEPPY NE PL+A+ +I  N  P L+N  ++S   + FL+R L  D  +R +A E
Sbjct: 489 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 548

Query: 566 LLKHPFLAKAGPPASIVPLM 585
           LL+HPFL  A P +S+ PL+
Sbjct: 549 LLQHPFLKLAKPLSSLTPLI 568



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 19/35 (54%), Positives = 23/35 (65%)

Query: 4  KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQ 38
          K K+R EIS PS+FEH +H GFD    +FT  P Q
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97


>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score =  319 bits (818), Expect = 4e-87
 Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)

Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
           A P S+ ++S PP     +           +    PP   P                 A+
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 212

Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
           PAVP     PP   +            QR+  +++ E+    L+ +V  GDP+     F 
Sbjct: 213 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 272

Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
           KIG+G++G V  A   ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V   +SY
Sbjct: 273 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 332

Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
           LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC   LQAL  LH+  VIHRDIKSD+
Sbjct: 333 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392

Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
           ILL  DG VKL+DFGFCAQ++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM 
Sbjct: 393 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452

Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
           IEMV+GEPPY NE PL+A+ +I  N  P L+N  ++S   + FL+R L  D  +R +A E
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 512

Query: 566 LLKHPFLAKAGPPASIVPLM 585
           LL+HPFL  A P +S+ PL+
Sbjct: 513 LLQHPFLKLAKPLSSLTPLI 532



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 23/43 (53%), Positives = 30/43 (69%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FTG+P QW  L++ S
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTS 105


>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score =  319 bits (818), Expect = 4e-87
 Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)

Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
           A P S+ ++S PP     +           +    PP   P                 A+
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 212

Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
           PAVP     PP   +            QR+  +++ E+    L+ +V  GDP+     F 
Sbjct: 213 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 272

Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
           KIG+G++G V  A   ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V   +SY
Sbjct: 273 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 332

Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
           LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC   LQAL  LH+  VIHRDIKSD+
Sbjct: 333 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392

Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
           ILL  DG VKL+DFGFCAQ++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM 
Sbjct: 393 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452

Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
           IEMV+GEPPY NE PL+A+ +I  N  P L+N  ++S   + FL+R L  D  +R +A E
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 512

Query: 566 LLKHPFLAKAGPPASIVPLM 585
           LL+HPFL  A P +S+ PL+
Sbjct: 513 LLQHPFLKLAKPLSSLTPLI 532



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 23/43 (53%), Positives = 30/43 (69%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FTG+P QW  L++ S
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTS 105


>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score =  319 bits (818), Expect = 4e-87
 Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)

Query: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
           A P S+ ++S PP     +           +    PP   P                 A+
Sbjct: 153 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 212

Query: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
           PAVP     PP   +            QR+  +++ E+    L+ +V  GDP+     F 
Sbjct: 213 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 272

Query: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
           KIG+G++G V  A   ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V   +SY
Sbjct: 273 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 332

Query: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
           LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC   LQAL  LH+  VIHRDIKSD+
Sbjct: 333 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 392

Query: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
           ILL  DG VKL+DFGFCAQ++ E  +R ++VGTPYWMAPE+++R  YGP+VDIWSLGIM 
Sbjct: 393 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452

Query: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
           IEMV+GEPPY NE PL+A+ +I  N  P L+N  ++S   + FL+R L  D  +R +A E
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 512

Query: 566 LLKHPFLAKAGPPASIVPLM 585
           LL+HPFL  A P +S+ PL+
Sbjct: 513 LLQHPFLKLAKPLSSLTPLI 532



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 23/43 (53%), Positives = 30/43 (69%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FTG+P QW  L++ S
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTS 105


>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
          Length = 545

 Score =  314 bits (805), Expect = 1e-85
 Identities = 154/293 (52%), Positives = 215/293 (73%)

Query: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
           Q++  ++S E+    L+ +V  GDP+     F KIG+G++G V  A   ++G+ VA+K+M
Sbjct: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301

Query: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
           +L++Q ++EL+ NE+++MR+ ++ N+V   +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361

Query: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
           +E QIAAVC   LQAL  LH+  VIHRDIKSD+ILL  DG VKL+DFGFCAQ++ E  +R
Sbjct: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421

Query: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
            ++VGTPYWMAPE+++R  YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I  N  
Sbjct: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481

Query: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 585
           P L+N  K+S   + FL+R L  D  +R +A ELL+H FL  A P +S+ PL+
Sbjct: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLI 534



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 23/43 (53%), Positives = 30/43 (69%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FTG+P QW  L++ S
Sbjct: 68  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110


>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
          Length = 553

 Score =  300 bits (767), Expect = 3e-81
 Identities = 146/276 (52%), Positives = 204/276 (73%)

Query: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
           Q++  ++S E+    L+ +V  GDP+     F KIG+G++G V  A   ++G+ VA+K+M
Sbjct: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301

Query: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
           +L++Q ++EL+ NE+++MR+ ++ N+V   +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361

Query: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
           +E QIAAVC   LQAL  LH+  VIHRDIKSD+ILL  DG VKL+DFGFCAQ++ E  +R
Sbjct: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421

Query: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
            ++VGTPYWMAPE+++R  YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I  N  
Sbjct: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481

Query: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 568
           P L+N  K+S   + FL+R L  D  +R +A ELL+
Sbjct: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 23/43 (53%), Positives = 30/43 (69%)

Query: 4   KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
           K K+R EIS PS+FEH +H GFD    +FTG+P QW  L++ S
Sbjct: 68  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  200 bits (509), Expect = 3e-51
 Identities = 104/273 (38%), Positives = 163/273 (59%), Gaps = 4/273 (1%)

Query: 317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 376
           P    D   K+GEGS G V  A  + SG++VA+K++ +    +   +  E+ IM+     
Sbjct: 23  PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSP 80

Query: 377 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAAVCLAVLQALSVLHAQ 434
            VV+ Y SY    +LW+VME+   G+++DI+   +  + E++IA +  + L+ L  LH  
Sbjct: 81  YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
             IHRDIK+ +ILL  +G  KL+DFG   Q++  + +R +++GTP+WMAPE+I  + Y  
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 200

Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
             DIWSLGI  IEM +G+PPY +  P++A+ MI  N PP  +     S     F+ + LV
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 260

Query: 555 RDPAQRATAAELLKHPFLAKAGPPASIVPLMRQ 587
           ++P QRATA +LL+HPF+  A P + +  L+ +
Sbjct: 261 KNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  199 bits (507), Expect = 5e-51
 Identities = 101/261 (38%), Positives = 158/261 (60%), Gaps = 4/261 (1%)

Query: 317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 376
           P    D   K+GEGS G V  A  + +G++VA+K++ +    +   +  E+ IM+     
Sbjct: 26  PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--IIKEISIMQQCDSP 83

Query: 377 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAAVCLAVLQALSVLHAQ 434
           +VV+ Y SY    +LW+VME+   G+++DI+   +  + E++IA +  + L+ L  LH  
Sbjct: 84  HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
             IHRDIK+ +ILL  +G  KL+DFG   Q++  + +R +++GTP+WMAPE+I  + Y  
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203

Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
             DIWSLGI  IEM +G+PPY +  P++A+ MI  N PP  +     S +   F+ + LV
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263

Query: 555 RDPAQRATAAELLKHPFLAKA 575
           + P QRATA +LL+HPF+  A
Sbjct: 264 KSPEQRATATQLLQHPFVRSA 284


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  192 bits (488), Expect = 7e-49
 Identities = 106/265 (40%), Positives = 166/265 (62%), Gaps = 6/265 (2%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
           +P+   +   +IG G+ G V  A   ++G+L A+K + L   +   ++  E+++M+D +H
Sbjct: 11  NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70

Query: 376 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 434
            N+V  + SYL  D+LW+ MEF  GG+L DI   T  ++E QIA V    LQ L  LH++
Sbjct: 71  PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLP 491
           G +HRDIK  +ILLT +G VKL+DFG  AQ++  + +RKS +GTPYWMAPE+ +   +  
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190

Query: 492 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAM-KMIRDNL-PPRLKNLHKVSPSLKGFL 549
           Y    D+W++GI  IE+ + +PP F+  P++A+  M + N  PP+LK+  K S S   F+
Sbjct: 191 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 250

Query: 550 DRLLVRDPAQRATAAELLKHPFLAK 574
              L ++P +R TA +LL+HPF+ +
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQ 275


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  189 bits (481), Expect = 5e-48
 Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
           DP        KIG+GS G V       + K+VA+K +DL + +   E +  E+ ++    
Sbjct: 19  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 434
              V + Y SYL   +LW++ME+L GG+  D++    ++E QIA +   +L+ L  LH++
Sbjct: 79  SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
             IHRDIK+ ++LL+  G VKL+DFG   Q++    +R + VGTP+WMAPE+I +  Y  
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198

Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
           + DIWSLGI  IE+  GEPP+    P+K + +I  N PP L+     S  LK F++  L 
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256

Query: 555 RDPAQRATAAELLKHPFLAK 574
           ++P+ R TA ELLKH F+ +
Sbjct: 257 KEPSFRPTAKELLKHKFILR 276


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  189 bits (481), Expect = 5e-48
 Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
           DP        KIG+GS G V       + K+VA+K +DL + +   E +  E+ ++    
Sbjct: 31  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90

Query: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 434
              V + Y SYL   +LW++ME+L GG+  D++    ++E QIA +   +L+ L  LH++
Sbjct: 91  SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 150

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
             IHRDIK+ ++LL+  G VKL+DFG   Q++    +R + VGTP+WMAPE+I +  Y  
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210

Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
           + DIWSLGI  IE+  GEPP+    P+K + +I  N PP L+     S  LK F++  L 
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 268

Query: 555 RDPAQRATAAELLKHPFLAK 574
           ++P+ R TA ELLKH F+ +
Sbjct: 269 KEPSFRPTAKELLKHKFILR 288


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  189 bits (480), Expect = 6e-48
 Identities = 101/260 (38%), Positives = 153/260 (58%), Gaps = 3/260 (1%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
           DP        +IG+GS G V       + ++VA+K +DL + +   E +  E+ ++    
Sbjct: 19  DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 434
              V + Y SYL G +LW++ME+L GG+  D++     +E QIA +   +L+ L  LH++
Sbjct: 79  SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 138

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 494
             IHRDIK+ ++LL+  G VKL+DFG   Q++    +R + VGTP+WMAPE+I +  Y  
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198

Query: 495 EVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLV 554
           + DIWSLGI  IE+  GEPP  +  P++ + +I  N PP L  +   + S K F+D  L 
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL--VGDFTKSFKEFIDACLN 256

Query: 555 RDPAQRATAAELLKHPFLAK 574
           +DP+ R TA ELLKH F+ K
Sbjct: 257 KDPSFRPTAKELLKHKFIVK 276


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  187 bits (475), Expect = 2e-47
 Identities = 108/276 (39%), Positives = 160/276 (57%), Gaps = 10/276 (3%)

Query: 311 VVDPG----DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 366
           VVDP     DPR + D   ++G G+ G V  A  + SG LVA+K + +        L  E
Sbjct: 3   VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE 62

Query: 367 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 425
           ++I++  +H N+V  + SYL   +LW+ MEF   G+L DI   T  ++E QI+ VC  VL
Sbjct: 63  ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL 122

Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
           Q L+ LH+Q  IHRDIK  +IL+   G V+L+DFG  AQ+   + RR S +GTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182

Query: 486 LIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHK 540
           + +   +  Y    DIWSLGI  IE+ + +PP F+  PL+ + ++  +   PPRLK   K
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 576
            S +   F+   L + P +R +A ++L H  +++ G
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPG 278


>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
           isoform 2 [Homo sapiens]
          Length = 833

 Score =  187 bits (475), Expect = 2e-47
 Identities = 108/276 (39%), Positives = 160/276 (57%), Gaps = 10/276 (3%)

Query: 311 VVDPG----DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNE 366
           VVDP     DPR + D   ++G G+ G V  A  + SG LVA+K + +        L  E
Sbjct: 3   VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE 62

Query: 367 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 425
           ++I++  +H N+V  + SYL   +LW+ MEF   G+L DI   T  ++E QI+ VC  VL
Sbjct: 63  ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL 122

Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
           Q L+ LH+Q  IHRDIK  +IL+   G V+L+DFG  AQ+   + RR S +GTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182

Query: 486 LIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHK 540
           + +   +  Y    DIWSLGI  IE+ + +PP F+  PL+ + ++  +   PPRLK   K
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 576
            S +   F+   L + P +R +A ++L H  +++ G
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPG 278


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  186 bits (473), Expect = 4e-47
 Identities = 106/276 (38%), Positives = 161/276 (58%), Gaps = 6/276 (2%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
           DPR   +   ++G G+ G V  A    + +L AVK + L        L  E+ I+R+ +H
Sbjct: 11  DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70

Query: 376 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 434
            NVV    SYL  D LW+ MEF  GG+L +I   T  + E QIA VC   L+ L  LH+Q
Sbjct: 71  PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQ 130

Query: 435 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLP 491
           G IHRDIK  ++LLT  G VKL+DFG   +++  V +R+S +GTPYWMAPE+ +   +  
Sbjct: 131 GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGG 190

Query: 492 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHKVSPSLKGFL 549
           Y    D+W+LGI  IE+ + +PP F+  P++A+ ++  +   PP+L++  + + +   FL
Sbjct: 191 YNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFL 250

Query: 550 DRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 585
              L ++P +R TA +LL+HPF  +  P A +  L+
Sbjct: 251 KLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLL 286


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  186 bits (472), Expect = 5e-47
 Identities = 104/272 (38%), Positives = 160/272 (58%), Gaps = 17/272 (6%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
           DP    +    +G G+ G V       +G+L A+K MD+   +  E+   E+ +++ Y H
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSH 78

Query: 376 E-NVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIAAVCLAVL 425
             N+   Y +++      + D+LW+VMEF   G++TD++ +T+ N   EE IA +C  +L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
           + LS LH   VIHRDIK  ++LLT +  VKL DFG  AQ+ + V RR + +GTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 486 LIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
           +I+        Y  + D+WSLGI  IEM +G PP  +  P++A+ +I  N  PRLK+  K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
            S   + F++  LV++ +QR    +L+KHPF+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 35/138 (25%), Positives = 49/138 (35%), Gaps = 15/138 (10%)

Query: 96  RSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAG 155
           RS+ LR++   PP   ++   +   PA   +  PG   + G   G       + D RR  
Sbjct: 574 RSSWLRQEEDIPPKVPQRTTSI--SPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631

Query: 156 PEKRPKSSREGSGGPQESSRDKRPLSGP-DVGTPQPAGLASGAKLAAGRPFNTYPRADTD 214
           P       R  SG    SS    P S P   G  QP   A  ++           R   +
Sbjct: 632 PILESPLQRTSSG---SSSSSSTPSSQPSSQGGSQPGSQAGSSERT---------RVRAN 679

Query: 215 HPSRGAQGEPHDVAPNGP 232
             S G+   PH+ A   P
Sbjct: 680 SKSEGSPVLPHEPAKVKP 697


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score =  186 bits (472), Expect = 5e-47
 Identities = 104/272 (38%), Positives = 160/272 (58%), Gaps = 17/272 (6%)

Query: 316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
           DP    +    +G G+ G V       +G+L A+K MD+   +  E+   E+ +++ Y H
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSH 78

Query: 376 E-NVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIAAVCLAVL 425
             N+   Y +++      + D+LW+VMEF   G++TD++ +T+ N   EE IA +C  +L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
           + LS LH   VIHRDIK  ++LLT +  VKL DFG  AQ+ + V RR + +GTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 486 LIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540
           +I+        Y  + D+WSLGI  IEM +G PP  +  P++A+ +I  N  PRLK+  K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257

Query: 541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
            S   + F++  LV++ +QR    +L+KHPF+
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 35/138 (25%), Positives = 49/138 (35%), Gaps = 15/138 (10%)

Query: 96  RSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAG 155
           RS+ LR++   PP   ++   +   PA   +  PG   + G   G       + D RR  
Sbjct: 574 RSSWLRQEEDIPPKVPQRTTSI--SPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 631

Query: 156 PEKRPKSSREGSGGPQESSRDKRPLSGP-DVGTPQPAGLASGAKLAAGRPFNTYPRADTD 214
           P       R  SG    SS    P S P   G  QP   A  ++           R   +
Sbjct: 632 PILESPLQRTSSG---SSSSSSTPSSQPSSQGGSQPGSQAGSSERT---------RVRAN 679

Query: 215 HPSRGAQGEPHDVAPNGP 232
             S G+   PH+ A   P
Sbjct: 680 SKSEGSPVLPHEPAKVKP 697


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,287,149
Number of Sequences: 37866
Number of extensions: 1824000
Number of successful extensions: 25229
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 868
Number of HSP's successfully gapped in prelim test: 1682
Number of HSP's that attempted gapping in prelim test: 12651
Number of HSP's gapped (non-prelim): 8517
length of query: 591
length of database: 18,247,518
effective HSP length: 108
effective length of query: 483
effective length of database: 14,157,990
effective search space: 6838309170
effective search space used: 6838309170
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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