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Search of human proteins with 5031751
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031751 hydroxymethylglutaryl-CoA synthase 2 [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031751 hydroxymethylglutaryl-CoA synthase 2 [Homo sapiens] 1024 0.0
gi|148298764 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] 665 0.0
gi|148298677 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] 665 0.0
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 30 4.0
gi|7657100 solute carrier family 40 (iron-regulated transporter)... 30 5.2
gi|239755033 PREDICTED: hypothetical protein XP_002346199 [Homo ... 30 6.8
gi|239749533 PREDICTED: hypothetical protein XP_002347079 [Homo ... 30 6.8
gi|239743682 PREDICTED: hypothetical protein XP_002342945 [Homo ... 30 6.8
gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isofor... 29 8.8
>gi|5031751 hydroxymethylglutaryl-CoA synthase 2 [Homo sapiens]
Length = 508
Score = 1024 bits (2647), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE 60
MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE
Sbjct: 1 MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE 60
Query: 61 VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP 120
VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP
Sbjct: 61 VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP 120
Query: 121 WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM 180
WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM
Sbjct: 121 WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM 180
Query: 181 ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD 240
ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD
Sbjct: 181 ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD 240
Query: 241 FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF 300
FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF
Sbjct: 241 FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF 300
Query: 301 HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS 360
HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS
Sbjct: 301 HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS 360
Query: 361 QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF 420
QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF
Sbjct: 361 QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF 420
Query: 421 FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG 480
FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG
Sbjct: 421 FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG 480
Query: 481 DTNSLFPGTWYLERVDEQHRRKYARRPV 508
DTNSLFPGTWYLERVDEQHRRKYARRPV
Sbjct: 481 DTNSLFPGTWYLERVDEQHRRKYARRPV 508
>gi|148298764 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens]
Length = 520
Score = 665 bits (1717), Expect = 0.0
Identities = 315/467 (67%), Positives = 387/467 (82%)
Query: 41 AVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQE 100
++PL WPKDVGI+ALE+YFP+QYVDQ +LEKY+ V+AGKYT+GLGQ +MGFC+ +E
Sbjct: 4 SLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDRE 63
Query: 101 DINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGI 160
DINSLC+TVVQ LMER L +D +GRLEVGTETIIDKSK+VKT LM+LF++SGNTDIEGI
Sbjct: 64 DINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGI 123
Query: 161 DTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGP 220
DTTNACYGGTA++FNA NW+ESSSWDGRYA+VV GDIAVY +GNARPTGG GAVA+LIGP
Sbjct: 124 DTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGP 183
Query: 221 KAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQ 280
APL ERGLRGTHM++ YDFYKP++ SEYPIVDGKLSIQCYL ALDRCY+ Y KKI Q
Sbjct: 184 NAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQ 243
Query: 281 WKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGG 340
W++ G+D+ FTL+D +MIFH+P+CK+VQKSLAR++ NDFL+ + + S+Y GLEAFG
Sbjct: 244 WQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGD 303
Query: 341 LKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQ 400
+KLEDTY ++D++KA +KAS ++F +KTKASL +S NGNMYTSS+YG LAS+L+ +S Q
Sbjct: 304 VKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQ 363
Query: 401 ELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEF 460
+LAG RIG FSYGSGLAA+ +S +V+QDA PGS LDK+ +S DL RL SR V+P+ F
Sbjct: 364 QLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVF 423
Query: 461 TEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRP 507
E M RE +H VN+ P G +SLF GTWYL RVDE+HRR YARRP
Sbjct: 424 AENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRP 470
>gi|148298677 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens]
Length = 520
Score = 665 bits (1717), Expect = 0.0
Identities = 315/467 (67%), Positives = 387/467 (82%)
Query: 41 AVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQE 100
++PL WPKDVGI+ALE+YFP+QYVDQ +LEKY+ V+AGKYT+GLGQ +MGFC+ +E
Sbjct: 4 SLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDRE 63
Query: 101 DINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGI 160
DINSLC+TVVQ LMER L +D +GRLEVGTETIIDKSK+VKT LM+LF++SGNTDIEGI
Sbjct: 64 DINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGI 123
Query: 161 DTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGP 220
DTTNACYGGTA++FNA NW+ESSSWDGRYA+VV GDIAVY +GNARPTGG GAVA+LIGP
Sbjct: 124 DTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGP 183
Query: 221 KAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQ 280
APL ERGLRGTHM++ YDFYKP++ SEYPIVDGKLSIQCYL ALDRCY+ Y KKI Q
Sbjct: 184 NAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQ 243
Query: 281 WKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGG 340
W++ G+D+ FTL+D +MIFH+P+CK+VQKSLAR++ NDFL+ + + S+Y GLEAFG
Sbjct: 244 WQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGD 303
Query: 341 LKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQ 400
+KLEDTY ++D++KA +KAS ++F +KTKASL +S NGNMYTSS+YG LAS+L+ +S Q
Sbjct: 304 VKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQ 363
Query: 401 ELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEF 460
+LAG RIG FSYGSGLAA+ +S +V+QDA PGS LDK+ +S DL RL SR V+P+ F
Sbjct: 364 QLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVF 423
Query: 461 TEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRP 507
E M RE +H VN+ P G +SLF GTWYL RVDE+HRR YARRP
Sbjct: 424 AENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRP 470
>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
Length = 650
Score = 30.4 bits (67), Expect = 4.0
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 426 SQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPP 479
S+D P D + LPK + SPE+ E MN EQ+ KVN S P
Sbjct: 504 SEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEK--EKMNPLEQYERKVNASVP 555
>gi|7657100 solute carrier family 40 (iron-regulated transporter),
member 1 [Homo sapiens]
Length = 571
Score = 30.0 bits (66), Expect = 5.2
Identities = 31/100 (31%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 379 GNMYTSSLYGCLASLLSHHSA-QELAGS--------RIGAFSYG--SGLAA-SFFSFRVS 426
G YT L G + S+L SA + G+ + G G SGLA S V
Sbjct: 330 GYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVI 389
Query: 427 QDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQ 466
PGSPLD VS D+ R + ++P + EI +
Sbjct: 390 SVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTE 429
>gi|239755033 PREDICTED: hypothetical protein XP_002346199 [Homo
sapiens]
Length = 537
Score = 29.6 bits (65), Expect = 6.8
Identities = 15/45 (33%), Positives = 25/45 (55%), Gaps = 3/45 (6%)
Query: 195 GDIAVYPSGNARPTGGAG---AVAMLIGPKAPLALERGLRGTHME 236
GD+ ++P GNAR GGA V + + + L G++G+ M+
Sbjct: 53 GDLLLHPVGNARVHGGAARQQCVGVKVFVDVHITLHNGVQGSFMD 97
>gi|239749533 PREDICTED: hypothetical protein XP_002347079 [Homo
sapiens]
Length = 537
Score = 29.6 bits (65), Expect = 6.8
Identities = 15/45 (33%), Positives = 25/45 (55%), Gaps = 3/45 (6%)
Query: 195 GDIAVYPSGNARPTGGAG---AVAMLIGPKAPLALERGLRGTHME 236
GD+ ++P GNAR GGA V + + + L G++G+ M+
Sbjct: 53 GDLLLHPVGNARVHGGAARQQCVGVKVFVDVHITLHNGVQGSFMD 97
>gi|239743682 PREDICTED: hypothetical protein XP_002342945 [Homo
sapiens]
Length = 537
Score = 29.6 bits (65), Expect = 6.8
Identities = 15/45 (33%), Positives = 25/45 (55%), Gaps = 3/45 (6%)
Query: 195 GDIAVYPSGNARPTGGAG---AVAMLIGPKAPLALERGLRGTHME 236
GD+ ++P GNAR GGA V + + + L G++G+ M+
Sbjct: 53 GDLLLHPVGNARVHGGAARQQCVGVKVFVDVHITLHNGVQGSFMD 97
>gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isoform B
[Homo sapiens]
Length = 336
Score = 29.3 bits (64), Expect = 8.8
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 6/70 (8%)
Query: 321 LSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGN 380
L+A++D +TS Y L+A L + T T ++ + LLK + D K +L+ H
Sbjct: 270 LAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFM-VVDNPQKFALFKRIHKDG 328
Query: 381 MYTSSLYGCL 390
GCL
Sbjct: 329 Q-----VGCL 333
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,547,468
Number of Sequences: 37866
Number of extensions: 796611
Number of successful extensions: 1750
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1747
Number of HSP's gapped (non-prelim): 9
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.