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Search of human proteins with 47717134
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47717134 CDC-like kinase 2 [Homo sapiens]
(498 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47717134 CDC-like kinase 2 [Homo sapiens] 1035 0.0
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 598 e-171
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 598 e-171
gi|10190706 CDC-like kinase 4 [Homo sapiens] 567 e-162
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 550 e-157
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 550 e-157
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 198 8e-51
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 198 1e-50
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 198 1e-50
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 189 4e-48
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 189 4e-48
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 185 7e-47
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 184 2e-46
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 175 7e-44
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 170 2e-42
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 157 2e-38
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 157 2e-38
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 152 5e-37
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 152 5e-37
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 147 2e-35
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 147 2e-35
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 132 7e-31
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 118 1e-26
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 118 1e-26
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 116 5e-26
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 1035 bits (2677), Expect = 0.0
Identities = 498/498 (100%), Positives = 498/498 (100%)
Query: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD 60
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
Sbjct: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD 60
Query: 61 DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR 120
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
Sbjct: 61 DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR 120
Query: 121 RRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCV 180
RRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCV
Sbjct: 121 RRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCV 180
Query: 181 DHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI 240
DHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI
Sbjct: 181 DHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI 240
Query: 241 SFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS 300
SFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS
Sbjct: 241 SFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS 300
Query: 301 DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQP 360
DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQP
Sbjct: 301 DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQP 360
Query: 361 CDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDW 420
CDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDW
Sbjct: 361 CDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDW 420
Query: 421 DENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFAR 480
DENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFAR
Sbjct: 421 DENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFAR 480
Query: 481 LRAEPPNKLWDSSRDISR 498
LRAEPPNKLWDSSRDISR
Sbjct: 481 LRAEPPNKLWDSSRDISR 498
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 598 bits (1542), Expect = e-171
Identities = 300/500 (60%), Positives = 370/500 (74%), Gaps = 12/500 (2%)
Query: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRS-SY 59
M H +RY S E + Y S + KRRRS S R R R + RSRS S+
Sbjct: 149 MHHCKRYRSPEP-------DPYLSYRWKRRRSYS-REHEGRLRYPSRREPPPRRSRSRSH 200
Query: 60 DDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHR 119
D RR +RR +YR + S G+ YY RE YR+++ + H+
Sbjct: 201 DRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHK 260
Query: 120 RRRRR-SRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQ 178
RR R S SRS S R ++SVEDD EGHL+ +GDWLQERYEIV LGEGTFG+VV+
Sbjct: 261 RRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVE 320
Query: 179 CVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHM 238
C+DH RG ++VALKII+NV KY+EAARLEINVL+KI EKD +NK LCV M DWF++HGHM
Sbjct: 321 CLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHM 380
Query: 239 CISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV 298
CI+FELLG +TF+FLK+NN+ PYP+ VRHMA+QLC A++FLH+N+LTHTDLKPENILFV
Sbjct: 381 CIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV 440
Query: 299 NSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWS 358
NS++E YN K +E+SVK+T++RV DFGSATFDHEHH+TIV+TRHYR PEVILELGW+
Sbjct: 441 NSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWA 500
Query: 359 QPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRL 418
QPCDVWSIGCI+FEYY GFTLFQTH+NREHL MME+ILGPIPS MI +TRKQKYFY+G L
Sbjct: 501 QPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL 560
Query: 419 DWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 478
WDEN+S GRYV+ENCKPL+ Y+ ++ EH QLFDL+ MLE++PA+R+TL EAL HPFF
Sbjct: 561 VWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 620
Query: 479 ARLRAEPPNKLWDSSRDISR 498
A L P + + +SR+ SR
Sbjct: 621 AGL--TPEERSFHTSRNPSR 638
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 598 bits (1542), Expect = e-171
Identities = 300/500 (60%), Positives = 370/500 (74%), Gaps = 12/500 (2%)
Query: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRS-SY 59
M H +RY S E + Y S + KRRRS S R R R + RSRS S+
Sbjct: 1 MHHCKRYRSPEP-------DPYLSYRWKRRRSYS-REHEGRLRYPSRREPPPRRSRSRSH 52
Query: 60 DDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHR 119
D RR +RR +YR + S G+ YY RE YR+++ + H+
Sbjct: 53 DRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHK 112
Query: 120 RRRRR-SRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQ 178
RR R S SRS S R ++SVEDD EGHL+ +GDWLQERYEIV LGEGTFG+VV+
Sbjct: 113 RRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVE 172
Query: 179 CVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHM 238
C+DH RG ++VALKII+NV KY+EAARLEINVL+KI EKD +NK LCV M DWF++HGHM
Sbjct: 173 CLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHM 232
Query: 239 CISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV 298
CI+FELLG +TF+FLK+NN+ PYP+ VRHMA+QLC A++FLH+N+LTHTDLKPENILFV
Sbjct: 233 CIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV 292
Query: 299 NSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWS 358
NS++E YN K +E+SVK+T++RV DFGSATFDHEHH+TIV+TRHYR PEVILELGW+
Sbjct: 293 NSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWA 352
Query: 359 QPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRL 418
QPCDVWSIGCI+FEYY GFTLFQTH+NREHL MME+ILGPIPS MI +TRKQKYFY+G L
Sbjct: 353 QPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL 412
Query: 419 DWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 478
WDEN+S GRYV+ENCKPL+ Y+ ++ EH QLFDL+ MLE++PA+R+TL EAL HPFF
Sbjct: 413 VWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
Query: 479 ARLRAEPPNKLWDSSRDISR 498
A L P + + +SR+ SR
Sbjct: 473 AGL--TPEERSFHTSRNPSR 490
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 567 bits (1461), Expect = e-162
Identities = 276/486 (56%), Positives = 353/486 (72%), Gaps = 11/486 (2%)
Query: 1 MPHPRRYHSSERGSRGSY-REHYRSRKHKRRRSRSWSSSSDRTRRR---RREDSYHVRSR 56
M H +R H + SR S+ E YR ++RRS S + + + + D +++ +R
Sbjct: 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR 60
Query: 57 SSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRR 116
S ++R DRRY YR NDY +Y D Y SS RS+RSS +
Sbjct: 61 SL-----NERDYRDRRYVDEYR-NDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPK 114
Query: 117 KHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRV 176
+ R R S SRS SH +R++S+EDD EGHLI GD L+ RYEIV TLGEG FG+V
Sbjct: 115 RKRNRHCSSHQ-SRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
Query: 177 VQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHG 236
V+C+DH G VA+KI+KNV +Y+EAAR EI VLE +N DP++ CVQM +WFD+HG
Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
Query: 237 HMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL 296
H+CI FELLGLST+DF+K+N++LP+ I +R MA+Q+CQ++ FLH NKLTHTDLKPENIL
Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL 293
Query: 297 FVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELG 356
FV SDY + YN + KRDER++K+T ++VVDFGSAT+D EHHST+VSTRHYRAPEVIL LG
Sbjct: 294 FVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG 353
Query: 357 WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRG 416
WSQPCDVWSIGCI+ EYY+GFT+FQTHD++EHLAMMERILGPIP MI+KTRK+KYF+
Sbjct: 354 WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN 413
Query: 417 RLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHP 476
+LDWDE++SAGRYVR CKPL+ ++ EEH +LFDL+ MLEY+P +R+TL EALQHP
Sbjct: 414 QLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHP 473
Query: 477 FFARLR 482
FF L+
Sbjct: 474 FFDLLK 479
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 550 bits (1418), Expect = e-157
Identities = 270/487 (55%), Positives = 349/487 (71%), Gaps = 11/487 (2%)
Query: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRRE----DSYHVRSR 56
M H +R + + + +RS +RR RS SS+ + R + DS+++ SR
Sbjct: 43 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 102
Query: 57 SSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSS-R 115
S +++ + RRY YR NDY++ + D+ Y+ SS RS RSS +
Sbjct: 103 SI-----NEKDYHSRRYIDEYR-NDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYK 156
Query: 116 RKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
KHR S S SH +R +SVEDD EGHLI GD L RYEIV TLGEG FG+
Sbjct: 157 SKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGK 216
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+C+DH+ GG VA+KI+KNV++Y EAAR EI VLE +N DP++ CVQM +WF++H
Sbjct: 217 VVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHH 276
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENI 295
GH+CI FELLGLST+DF+K+N +LP+ + +R MA+Q+C++V FLH NKLTHTDLKPENI
Sbjct: 277 GHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENI 336
Query: 296 LFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILEL 355
LFV SDY YN + KRDER++ + ++VVDFGSAT+D EHHST+VSTRHYRAPEVIL L
Sbjct: 337 LFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILAL 396
Query: 356 GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYR 415
GWSQPCDVWSIGCI+ EYY+GFT+F THD++EHLAMMERILGP+P MI+KTRK+KYF+
Sbjct: 397 GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHH 456
Query: 416 GRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQH 475
RLDWDE++SAGRYV CKPL+ ++ S+ EH +LFDLI+ MLEY+PAKR+TL EAL+H
Sbjct: 457 DRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 516
Query: 476 PFFARLR 482
PFF L+
Sbjct: 517 PFFDLLK 523
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 550 bits (1418), Expect = e-157
Identities = 270/487 (55%), Positives = 349/487 (71%), Gaps = 11/487 (2%)
Query: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRRE----DSYHVRSR 56
M H +R + + + +RS +RR RS SS+ + R + DS+++ SR
Sbjct: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
Query: 57 SSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSS-R 115
S +++ + RRY YR NDY++ + D+ Y+ SS RS RSS +
Sbjct: 61 SI-----NEKDYHSRRYIDEYR-NDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYK 114
Query: 116 RKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
KHR S S SH +R +SVEDD EGHLI GD L RYEIV TLGEG FG+
Sbjct: 115 SKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGK 174
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+C+DH+ GG VA+KI+KNV++Y EAAR EI VLE +N DP++ CVQM +WF++H
Sbjct: 175 VVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHH 234
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENI 295
GH+CI FELLGLST+DF+K+N +LP+ + +R MA+Q+C++V FLH NKLTHTDLKPENI
Sbjct: 235 GHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENI 294
Query: 296 LFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILEL 355
LFV SDY YN + KRDER++ + ++VVDFGSAT+D EHHST+VSTRHYRAPEVIL L
Sbjct: 295 LFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILAL 354
Query: 356 GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYR 415
GWSQPCDVWSIGCI+ EYY+GFT+F THD++EHLAMMERILGP+P MI+KTRK+KYF+
Sbjct: 355 GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHH 414
Query: 416 GRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQH 475
RLDWDE++SAGRYV CKPL+ ++ S+ EH +LFDLI+ MLEY+PAKR+TL EAL+H
Sbjct: 415 DRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 474
Query: 476 PFFARLR 482
PFF L+
Sbjct: 475 PFFDLLK 481
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 198 bits (504), Expect = 8e-51
Identities = 111/349 (31%), Positives = 192/349 (55%), Gaps = 22/349 (6%)
Query: 139 AKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE 198
+K+ DD G + + D + RYE++ T+G+G+FG+V +C+DH+ VALKII+N +
Sbjct: 81 SKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNEL-VALKIIRNKK 139
Query: 199 KYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNY 258
++ + A +E+ +LE + +KD DN V M D+F + H CI+FELLG++ ++ +K+NN+
Sbjct: 140 RFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNF 199
Query: 259 LPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVK 318
+ + VR + + ++ L K+ H DLKPENI+
Sbjct: 200 QGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG----------------- 242
Query: 319 STAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFT 378
+V+V+DFGS+ ++H+ T + +R YR+PEVIL + D+WS+GCI E Y G+
Sbjct: 243 QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYP 302
Query: 379 LFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLR 438
LF + E LA + +LG P+ I+ +++ F+ + + +N + R + P
Sbjct: 303 LFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSK-GFPKNITNNRGKKR--YPDS 359
Query: 439 RYLTSEAEEHHQLF-DLIESMLEYEPAKRLTLGEALQHPFFARLRAEPP 486
+ LT + + F D + L +EP+ R+T +AL+H + + R P
Sbjct: 360 KDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKP 408
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 198 bits (503), Expect = 1e-50
Identities = 113/358 (31%), Positives = 185/358 (51%), Gaps = 33/358 (9%)
Query: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203
DD +G + D + RYE++ +G+G+FG+VV+ DH+ VALK+++N +++
Sbjct: 204 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 262
Query: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263
A EI +LE + ++D DN + M + F + H+C++FELL ++ ++ +K N + + +
Sbjct: 263 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 322
Query: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
VR A + Q + LH N++ H DLKPENIL K+ RS ++
Sbjct: 323 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-------------KQQGRS----GIK 365
Query: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383
V+DFGS+ ++H+ T + +R YRAPEVIL + P D+WS+GCI+ E G+ L
Sbjct: 366 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 425
Query: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439
D + LA M +LG +++ +++ K F R S G V + R
Sbjct: 426 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 485
Query: 440 YLTSEAEEHH-----------QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPP 486
L E D ++ LE++PA R+T G+AL+HP+ R +PP
Sbjct: 486 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP 543
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 198 bits (503), Expect = 1e-50
Identities = 113/358 (31%), Positives = 185/358 (51%), Gaps = 33/358 (9%)
Query: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203
DD +G + D + RYE++ +G+G+FG+VV+ DH+ VALK+++N +++
Sbjct: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
Query: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263
A EI +LE + ++D DN + M + F + H+C++FELL ++ ++ +K N + + +
Sbjct: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
Query: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
VR A + Q + LH N++ H DLKPENIL K+ RS ++
Sbjct: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-------------KQQGRS----GIK 292
Query: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383
V+DFGS+ ++H+ T + +R YRAPEVIL + P D+WS+GCI+ E G+ L
Sbjct: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
Query: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439
D + LA M +LG +++ +++ K F R S G V + R
Sbjct: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
Query: 440 YLTSEAEEHH-----------QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPP 486
L E D ++ LE++PA R+T G+AL+HP+ R +PP
Sbjct: 413 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP 470
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 189 bits (481), Expect = 4e-48
Identities = 110/357 (30%), Positives = 185/357 (51%), Gaps = 33/357 (9%)
Query: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203
DDA+G I+ D L RYE++ +G+G+FG+V + DH+ VALK+++N +++
Sbjct: 171 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 229
Query: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263
A EI +LE + ++D + M + F + H+C++FELL + ++ +K N + + +
Sbjct: 230 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 289
Query: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
VR A + Q++ LH NK+ H DLKPENIL K RS + +
Sbjct: 290 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-------------KHHGRS----STK 332
Query: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383
V+DFGS+ F+++ T + +R YRAPE+IL +S P D+WS GCI+ E G LF
Sbjct: 333 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 392
Query: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439
D + LA M +LG P +++ ++++ KYF R + GR V + R
Sbjct: 393 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 452
Query: 440 Y-----------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 485
+ + + + ++ L ++P+ RLT +AL+HP+ ++ P
Sbjct: 453 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 509
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 189 bits (481), Expect = 4e-48
Identities = 110/357 (30%), Positives = 185/357 (51%), Gaps = 33/357 (9%)
Query: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203
DDA+G I+ D L RYE++ +G+G+FG+V + DH+ VALK+++N +++
Sbjct: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
Query: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263
A EI +LE + ++D + M + F + H+C++FELL + ++ +K N + + +
Sbjct: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
Query: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
VR A + Q++ LH NK+ H DLKPENIL K RS + +
Sbjct: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-------------KHHGRS----STK 352
Query: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383
V+DFGS+ F+++ T + +R YRAPE+IL +S P D+WS GCI+ E G LF
Sbjct: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
Query: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439
D + LA M +LG P +++ ++++ KYF R + GR V + R
Sbjct: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
Query: 440 Y-----------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 485
+ + + + ++ L ++P+ RLT +AL+HP+ ++ P
Sbjct: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 185 bits (470), Expect = 7e-47
Identities = 122/377 (32%), Positives = 196/377 (51%), Gaps = 35/377 (9%)
Query: 118 HRRRRRRSRTFSRSSSHSSRRAKSV----EDDAEGHLIYHVGDWLQERYEIVSTLGEGTF 173
+ +++RR++ S + + K + +DD +++ WL ERYEI S +G+G+F
Sbjct: 64 YAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWL-ERYEIDSLIGKGSF 122
Query: 174 GRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD 233
G+VV+ DH+ VA+KIIKN + + A++E+ +LE +N+ D + K V + F
Sbjct: 123 GQVVKAYDHQT-QELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFM 181
Query: 234 YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLK 291
+ H+C+ FELL + +D L++ ++ ++ R +A QLC A+ FL +L+ H DLK
Sbjct: 182 FRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLK 241
Query: 292 PENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEV 351
PENIL N K +A+++VDFGS+ + + +R YR+PEV
Sbjct: 242 PENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEV 284
Query: 352 ILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRK-Q 410
+L + D+WS+GCI+ E + G LF + + + + +LG P+ M+ + K +
Sbjct: 285 LLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKAR 344
Query: 411 KYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG 470
KYF E G + K LR+ Q DL+ MLEYEPA R++
Sbjct: 345 KYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLEYEPAARISPL 395
Query: 471 EALQHPFFARLRAEPPN 487
ALQH FF R E N
Sbjct: 396 GALQHGFFRRTADEATN 412
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 184 bits (466), Expect = 2e-46
Identities = 121/377 (32%), Positives = 195/377 (51%), Gaps = 47/377 (12%)
Query: 118 HRRRRRRSRTFSRSSSHSSRRAKSV----EDDAEGHLIYHVGDWLQERYEIVSTLGEGTF 173
+ +++RR++ S + + K + +DD +++ WL ERYEI S +G+G+F
Sbjct: 64 YAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWL-ERYEIDSLIGKGSF 122
Query: 174 GRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD 233
G+VV+ DH+ VA+KIIKN + + A++E+ +LE +N+ D + K V + F
Sbjct: 123 GQVVKAYDHQT-QELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFM 181
Query: 234 YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLK 291
+ H+C+ FELL + +D L++ ++ ++ R +A QLC A+ FL +L+ H DLK
Sbjct: 182 FRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLK 241
Query: 292 PENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEV 351
PENIL N K +A+++VDFGS+ + + +R YR+PEV
Sbjct: 242 PENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEV 284
Query: 352 ILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRK-Q 410
+L + D+WS+GCI+ E + G LF + + + + +LG P+ M+ + K +
Sbjct: 285 LLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKAR 344
Query: 411 KYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG 470
KYF E G + K LR+ DL+ MLEYEPA R++
Sbjct: 345 KYF--------ERLPGGGWTLRRTKELRK-------------DLVLRMLEYEPAARISPL 383
Query: 471 EALQHPFFARLRAEPPN 487
ALQH FF R E N
Sbjct: 384 GALQHGFFRRTADEATN 400
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 175 bits (444), Expect = 7e-44
Identities = 121/404 (29%), Positives = 198/404 (49%), Gaps = 61/404 (15%)
Query: 118 HRRRRRRSRTFSRSSSHSSRRAKSV----EDDAEGHLIYHVGDWLQERYEIVSTLGEGTF 173
+ +++RR++ S + + K + +DD +++ WL ERYEI S +G+G+F
Sbjct: 64 YAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWL-ERYEIDSLIGKGSF 122
Query: 174 GRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD 233
G+VV+ DH+ VA+KIIKN + + A++E+ +LE +N+ D + K V + F
Sbjct: 123 GQVVKAYDHQT-QELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFM 181
Query: 234 YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLK 291
+ H+C+ FELL + +D L++ ++ ++ R +A QLC A+ FL +L+ H DLK
Sbjct: 182 FRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLK 241
Query: 292 PENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEV 351
PENIL N K +A+++VDFGS+ + + +R YR+PEV
Sbjct: 242 PENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEV 284
Query: 352 ILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRK-Q 410
+L + D+WS+GCI+ E + G LF + + + + +LG P+ M+ + K +
Sbjct: 285 LLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKAR 344
Query: 411 KYFYRGRLDWDENTSAGRYVRENCKPLRRYLTS--------------------------- 443
KYF E G + K LR+
Sbjct: 345 KYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGH 396
Query: 444 EAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
++ + DL+ MLEYEPA R++ ALQH FF R E N
Sbjct: 397 SPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 171 bits (434), Expect = 1e-42
Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)
Query: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
+++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 172
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F +
Sbjct: 173 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293
H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353
NIL N K +A+++VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413
+ + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453
+ D W+ + T G+ Y + L L E ++ + D
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 454
Query: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
LI ML+Y+P R+ ALQH FF + E N
Sbjct: 455 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 171 bits (434), Expect = 1e-42
Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)
Query: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
+++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 172
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F +
Sbjct: 173 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293
H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353
NIL N K +A+++VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413
+ + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453
+ D W+ + T G+ Y + L L E ++ + D
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 454
Query: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
LI ML+Y+P R+ ALQH FF + E N
Sbjct: 455 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 171 bits (434), Expect = 1e-42
Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)
Query: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
+++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 172
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F +
Sbjct: 173 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293
H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353
NIL N K +A+++VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413
+ + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453
+ D W+ + T G+ Y + L L E ++ + D
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 454
Query: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
LI ML+Y+P R+ ALQH FF + E N
Sbjct: 455 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 171 bits (434), Expect = 1e-42
Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)
Query: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
+++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+
Sbjct: 105 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 163
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F +
Sbjct: 164 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 222
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293
H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE
Sbjct: 223 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 282
Query: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353
NIL N K +A+++VDFGS+ + + +R YR+PEV+L
Sbjct: 283 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 325
Query: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413
+ + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F
Sbjct: 326 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 385
Query: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453
+ D W+ + T G+ Y + L L E ++ + D
Sbjct: 386 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 445
Query: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
LI ML+Y+P R+ ALQH FF + E N
Sbjct: 446 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 479
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 171 bits (434), Expect = 1e-42
Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)
Query: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
+++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 172
Query: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F +
Sbjct: 173 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293
H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353
NIL N K +A+++VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413
+ + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453
+ D W+ + T G+ Y + L L E ++ + D
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 454
Query: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
LI ML+Y+P R+ ALQH FF + E N
Sbjct: 455 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 170 bits (431), Expect = 2e-42
Identities = 110/351 (31%), Positives = 182/351 (51%), Gaps = 36/351 (10%)
Query: 145 DAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAA 204
DAEG+ ++G+ L +RY + G+G F VV+ D+ R VA+KII+N E ++
Sbjct: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
Query: 205 RLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKD-NNYLPYPI 263
E+ L+K+N+ DPD+K C+++F F + H+C+ FE L ++ + LK + I
Sbjct: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
Query: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
VR + QL A+K L + H D+KP+NIL S T ++
Sbjct: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES------------------KTILK 831
Query: 324 VVDFGSATFDHEHHST-IVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQT 382
+ DFGSA+ ++ T + +R YRAPE+I+ + D+WS+GC ++E Y G LF
Sbjct: 832 LCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 891
Query: 383 HDNREHLAMMERILGPIPSRMIRK-TRKQKYFYRG----RLDWDENTSAGRY-VRENCKP 436
N L + + G +P++MIRK K ++F + ++ D+ T + V P
Sbjct: 892 KTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINP 951
Query: 437 LRRYLT----------SEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
+ L + ++ HQL DL++ +L +PAKR+++ +ALQH F
Sbjct: 952 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
Score = 40.8 bits (94), Expect = 0.003
Identities = 51/162 (31%), Positives = 64/162 (39%), Gaps = 23/162 (14%)
Query: 2 PHPRRYHSSERGSRGSYREHYRSRKHKRRRS---RSWSSSSDRTRR---RRREDSYHVRS 55
P PR R + R +S+ R S R+ S S +R RR RRR S R
Sbjct: 357 PKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRP 416
Query: 56 RS---SYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQR 112
R S +RS D +R +S R + R +R S R R
Sbjct: 417 RDDILSRRERSKDASPINR----------WSPTRRRSRSPIRRRSRSPLRRSRSPRRRSR 466
Query: 113 SSRRKHRRRRRRSRTFSRSSSHSSRRAKS----VEDDAEGHL 150
S RR+ R RR RSR RS S RR +S ED +G L
Sbjct: 467 SPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSL 508
Score = 32.3 bits (72), Expect = 1.0
Identities = 37/148 (25%), Positives = 62/148 (41%), Gaps = 16/148 (10%)
Query: 6 RYHSSERGSRGSYR----EHYRSRKHKRRRSRS---WSSSSDRTRR------RRREDSYH 52
R+ S ++ S+G + RS+ +R++S+S S S D+ R+ RRR
Sbjct: 193 RHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKI 252
Query: 53 VRSRSSYDD--RSSDRRVYDRRYCGSYRRNDYSRDRG-DAYYDTDYRHSYEYQRENSSYR 109
++RS DD + D+ R SRDRG + D R + +R S R
Sbjct: 253 GKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKER 312
Query: 110 SQRSSRRKHRRRRRRSRTFSRSSSHSSR 137
+ S ++ +S + SS +R
Sbjct: 313 KSKRSETDKEKKPIKSPSKDASSGKENR 340
Score = 32.0 bits (71), Expect = 1.3
Identities = 39/129 (30%), Positives = 49/129 (37%), Gaps = 2/129 (1%)
Query: 19 REHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSR-SSYDDRSSDRRVYDRRYCGSY 77
R RS + KRR SS RTR R S RS+ +S +R S R R
Sbjct: 391 RAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRR 450
Query: 78 RRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSR 137
R+ R R R +R S R +RS R RRRR RS+ S
Sbjct: 451 SRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLR-RRSRSRGGRRRRSRSKVKEDKFKGSLS 509
Query: 138 RAKSVEDDA 146
VE ++
Sbjct: 510 EGMKVEQES 518
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 157 bits (398), Expect = 2e-38
Identities = 111/382 (29%), Positives = 192/382 (50%), Gaps = 55/382 (14%)
Query: 131 SSSHSSRRAKSVEDDAEG--HLIYH-VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGA 187
+++ S+ +K+ ++EG L+ H V + YE++ LG GTFG+VV+C +RG
Sbjct: 165 TATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC--WKRGTN 222
Query: 188 R-VALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG 246
VA+KI+KN Y ++E+++L +++ + D+ N V+ ++ F + H C+ FE+L
Sbjct: 223 EIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNF-VRAYECFQHKNHTCLVFEMLE 281
Query: 247 LSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTY 306
+ +DFLK N + P P+ +R + Q+ A+ L L H DLKPENI+ V
Sbjct: 282 QNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-------- 333
Query: 307 NLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 365
+ S + V+V+DFGSA+ ST + +R+YRAPE+IL L + + D+WS
Sbjct: 334 -------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
Query: 366 IGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PIPSRMIRKTRKQKYFYRG-------- 416
+GC+I E ++G+ L+ + + + + G P + T+ ++F R
Sbjct: 387 LGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLW 446
Query: 417 RLDWDENTSAGRYVRENCKPLRRYLTS---------------------EAEEHHQLFDLI 455
RL ++ A ++ K R+Y+ + E + + DL+
Sbjct: 447 RLKTPDDHEAETGIKS--KEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLL 504
Query: 456 ESMLEYEPAKRLTLGEALQHPF 477
+ ML + KR+T E L HPF
Sbjct: 505 KKMLTIDADKRITPIETLNHPF 526
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 157 bits (398), Expect = 2e-38
Identities = 111/382 (29%), Positives = 192/382 (50%), Gaps = 55/382 (14%)
Query: 131 SSSHSSRRAKSVEDDAEG--HLIYH-VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGA 187
+++ S+ +K+ ++EG L+ H V + YE++ LG GTFG+VV+C +RG
Sbjct: 165 TATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC--WKRGTN 222
Query: 188 R-VALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG 246
VA+KI+KN Y ++E+++L +++ + D+ N V+ ++ F + H C+ FE+L
Sbjct: 223 EIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNF-VRAYECFQHKNHTCLVFEMLE 281
Query: 247 LSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTY 306
+ +DFLK N + P P+ +R + Q+ A+ L L H DLKPENI+ V
Sbjct: 282 QNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-------- 333
Query: 307 NLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 365
+ S + V+V+DFGSA+ ST + +R+YRAPE+IL L + + D+WS
Sbjct: 334 -------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
Query: 366 IGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PIPSRMIRKTRKQKYFYRG-------- 416
+GC+I E ++G+ L+ + + + + G P + T+ ++F R
Sbjct: 387 LGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLW 446
Query: 417 RLDWDENTSAGRYVRENCKPLRRYLTS---------------------EAEEHHQLFDLI 455
RL ++ A ++ K R+Y+ + E + + DL+
Sbjct: 447 RLKTPDDHEAETGIKS--KEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLL 504
Query: 456 ESMLEYEPAKRLTLGEALQHPF 477
+ ML + KR+T E L HPF
Sbjct: 505 KKMLTIDADKRITPIETLNHPF 526
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 152 bits (385), Expect = 5e-37
Identities = 100/350 (28%), Positives = 172/350 (49%), Gaps = 48/350 (13%)
Query: 158 LQERYEIVSTLGEGTFGRVVQCVDHRRGGAR-VALKIIKNVEKYKEAARLEINVLEKINE 216
++ YE++ LG GTFG+VV+C +RG VA+KI+KN Y ++E+++L +++
Sbjct: 193 MKNTYEVLDFLGRGTFGQVVKC--WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
Query: 217 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 276
++ D N V+ ++ F + H C+ FE+L + +DFLK N + P P+ +R + Q+ A
Sbjct: 251 ENADEYNF-VRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
Query: 277 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHE 335
+K L L H DLKPENI+ V+ + V+V+DFGSA+
Sbjct: 310 LKKLKSLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKT 354
Query: 336 HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERI 395
ST + +R+YRAPE+IL L + + D+WS+GC+I E ++G+ L+ + + + +
Sbjct: 355 VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQT 414
Query: 396 LGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVREN-------CKPLRRY-------- 440
G +++ K F+ D + + + E+ K R+Y
Sbjct: 415 QGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDV 474
Query: 441 -------------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
L +E + + L++ ML + R+T E L HPF
Sbjct: 475 AHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 152 bits (385), Expect = 5e-37
Identities = 100/350 (28%), Positives = 172/350 (49%), Gaps = 48/350 (13%)
Query: 158 LQERYEIVSTLGEGTFGRVVQCVDHRRGGAR-VALKIIKNVEKYKEAARLEINVLEKINE 216
++ YE++ LG GTFG+VV+C +RG VA+KI+KN Y ++E+++L +++
Sbjct: 193 MKNTYEVLDFLGRGTFGQVVKC--WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
Query: 217 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 276
++ D N V+ ++ F + H C+ FE+L + +DFLK N + P P+ +R + Q+ A
Sbjct: 251 ENADEYNF-VRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
Query: 277 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHE 335
+K L L H DLKPENI+ V+ + V+V+DFGSA+
Sbjct: 310 LKKLKSLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKT 354
Query: 336 HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERI 395
ST + +R+YRAPE+IL L + + D+WS+GC+I E ++G+ L+ + + + +
Sbjct: 355 VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQT 414
Query: 396 LGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVREN-------CKPLRRY-------- 440
G +++ K F+ D + + + E+ K R+Y
Sbjct: 415 QGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDV 474
Query: 441 -------------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
L +E + + L++ ML + R+T E L HPF
Sbjct: 475 AHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 147 bits (371), Expect = 2e-35
Identities = 99/345 (28%), Positives = 167/345 (48%), Gaps = 46/345 (13%)
Query: 162 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 221
YE++ LG GTFG+V +C R VA+KI+KN Y ++E+++L +++ ++ D
Sbjct: 190 YEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE 248
Query: 222 KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLH 281
N V+ ++ F + H C+ FE+L + +DFLK N + P P+ +R + Q+ A+ L
Sbjct: 249 YNF-VRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLK 307
Query: 282 DNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTI 340
L H DLKPENI+ V+ + V+V+DFGSA+ ST
Sbjct: 308 SLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKAVCSTY 352
Query: 341 VSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PI 399
+ +R+YRAPE+IL L + + D+WS+GC+I E ++G+ L+ + + + + G P
Sbjct: 353 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 412
Query: 400 PSRMIRKTRKQKYFYR----GRLDWDENTSAGRYVRE--NCKPLRRY------------- 440
+ T+ ++F R G W T + K R+Y
Sbjct: 413 EYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
Query: 441 --------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
+ +E + + DL++ ML + KR+T + L H F
Sbjct: 473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 147 bits (371), Expect = 2e-35
Identities = 99/345 (28%), Positives = 167/345 (48%), Gaps = 46/345 (13%)
Query: 162 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 221
YE++ LG GTFG+V +C R VA+KI+KN Y ++E+++L +++ ++ D
Sbjct: 190 YEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE 248
Query: 222 KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLH 281
N V+ ++ F + H C+ FE+L + +DFLK N + P P+ +R + Q+ A+ L
Sbjct: 249 YNF-VRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLK 307
Query: 282 DNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTI 340
L H DLKPENI+ V+ + V+V+DFGSA+ ST
Sbjct: 308 SLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKAVCSTY 352
Query: 341 VSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PI 399
+ +R+YRAPE+IL L + + D+WS+GC+I E ++G+ L+ + + + + G P
Sbjct: 353 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 412
Query: 400 PSRMIRKTRKQKYFYR----GRLDWDENTSAGRYVRE--NCKPLRRY------------- 440
+ T+ ++F R G W T + K R+Y
Sbjct: 413 EYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
Query: 441 --------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
+ +E + + DL++ ML + KR+T + L H F
Sbjct: 473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 132 bits (332), Expect = 7e-31
Identities = 95/353 (26%), Positives = 165/353 (46%), Gaps = 54/353 (15%)
Query: 162 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 221
Y+I+ LG+GTFG V + R G VA+KI+KN + E+ +L + DP+
Sbjct: 11 YDIIEVLGKGTFGEVAKGW-RRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Query: 222 KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLH 281
++ ++ ++F + FELL + F+F K+NN+ P P +R + Q+ A+ L
Sbjct: 70 AHV-IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
Query: 282 DNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHH---S 338
+ + H DLKPENI+ V +++ V+V+DFGSA+ E
Sbjct: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173
Query: 339 TIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGP 398
+ +R YRAPE++L L + + DVWS+GC++ E ++G+ L+ ++ + + + G
Sbjct: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
Query: 399 IPSRMIRKTRKQKYFYR------GRLDWDENTSAGRYVRENCKPL--RRYLTSEAE---- 446
++ K +F++ W +SA +PL R+Y+ +
Sbjct: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
Query: 447 -------------------EHHQL---FDLIESMLEYEPAKRLTLGEALQHPF 477
EH L +LI+ ML +E +R++ AL+HPF
Sbjct: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 118 bits (296), Expect = 1e-26
Identities = 86/331 (25%), Positives = 159/331 (48%), Gaps = 44/331 (13%)
Query: 158 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEK 217
+ ++EI+ +GEG +G V++C H+ VA+K K+ E+ +E + L+ +
Sbjct: 9 VMNKFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 218 DPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLP--YPIHQVRHMAFQLCQ 275
+N V++ + F G + + FE + + + L++ +P P +V+ +QL +
Sbjct: 68 KQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEE---MPNGVPPEKVKSYIYQLIK 121
Query: 276 AVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF--- 332
A+ + H N + H D+KPEN+L ++D +++ DFG A
Sbjct: 122 AIHWCHKNDIVHRDIKPENLLISHND-------------------VLKLCDFGFARNLSE 162
Query: 333 -DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 391
++ +++ V+TR YR+PE++L + + D+WS+GCI+ E G LF + L
Sbjct: 163 GNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFT 222
Query: 392 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 451
++++LGP+PS ++ F+ R V RRYL + L
Sbjct: 223 IQKVLGPLPSEQMKLFYSNPRFHGLRFP---------AVNHPQSLERRYL---GILNSVL 270
Query: 452 FDLIESMLEYEPAKRLTLGEALQHPFFARLR 482
DL++++L+ +PA R + L HP F R
Sbjct: 271 LDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 301
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 118 bits (296), Expect = 1e-26
Identities = 86/331 (25%), Positives = 159/331 (48%), Gaps = 44/331 (13%)
Query: 158 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEK 217
+ ++EI+ +GEG +G V++C H+ VA+K K+ E+ +E + L+ +
Sbjct: 9 VMNKFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 218 DPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLP--YPIHQVRHMAFQLCQ 275
+N V++ + F G + + FE + + + L++ +P P +V+ +QL +
Sbjct: 68 KQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEE---MPNGVPPEKVKSYIYQLIK 121
Query: 276 AVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF--- 332
A+ + H N + H D+KPEN+L ++D +++ DFG A
Sbjct: 122 AIHWCHKNDIVHRDIKPENLLISHND-------------------VLKLCDFGFARNLSE 162
Query: 333 -DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 391
++ +++ V+TR YR+PE++L + + D+WS+GCI+ E G LF + L
Sbjct: 163 GNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFT 222
Query: 392 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 451
++++LGP+PS ++ F+ R V RRYL + L
Sbjct: 223 IQKVLGPLPSEQMKLFYSNPRFHGLRFP---------AVNHPQSLERRYL---GILNSVL 270
Query: 452 FDLIESMLEYEPAKRLTLGEALQHPFFARLR 482
DL++++L+ +PA R + L HP F R
Sbjct: 271 LDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 301
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 116 bits (290), Expect = 5e-26
Identities = 92/335 (27%), Positives = 157/335 (46%), Gaps = 55/335 (16%)
Query: 160 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARL----EINVLEKIN 215
++YE V+ +GEG +G+V + D + GG VALK ++ V+ +E L E+ VL +
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR-VQTGEEGMPLSTIREVAVLRHLE 69
Query: 216 EKDPDNKNLCVQMFDWF-----DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMA 270
+ N V++FD D + + FE + +L P ++ M
Sbjct: 70 TFEHPN---VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126
Query: 271 FQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA 330
FQL + + FLH +++ H DLKP+NIL +S +++ DFG A
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------------------IKLADFGLA 167
Query: 331 TFDHEHHS--TIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREH 388
+ ++V T YRAPEV+L+ ++ P D+WS+GCI E + LF+ + +
Sbjct: 168 RIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ 227
Query: 389 LAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGR--YVRENCKPLRRYLTSEAE 446
L + ++G +P G DW + + R + ++ +P+ +++T E
Sbjct: 228 LGKILDVIG-LP---------------GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDE 271
Query: 447 EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARL 481
DL+ L + PAKR++ AL HP+F L
Sbjct: 272 LGK---DLLLKCLTFNPAKRISAYSALSHPYFQDL 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,333,101
Number of Sequences: 37866
Number of extensions: 845196
Number of successful extensions: 8882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 567
Number of HSP's successfully gapped in prelim test: 379
Number of HSP's that attempted gapping in prelim test: 3411
Number of HSP's gapped (non-prelim): 2787
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.