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Search of human proteins with 47604944
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47604944 SCY1-like 2 protein [Homo sapiens]
(929 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47604944 SCY1-like 2 protein [Homo sapiens] 1851 0.0
gi|115430243 SCY1-like 1 isoform B [Homo sapiens] 122 1e-27
gi|115430241 SCY1-like 1 isoform A [Homo sapiens] 122 1e-27
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 72 3e-12
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 72 3e-12
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 72 3e-12
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 72 3e-12
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 72 3e-12
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 72 3e-12
gi|170784850 SCY1-like 3 isoform 2 [Homo sapiens] 70 7e-12
gi|170784842 SCY1-like 3 isoform 1 [Homo sapiens] 70 7e-12
gi|41872374 polo-like kinase 3 [Homo sapiens] 61 4e-09
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 59 2e-08
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 59 2e-08
gi|4758700 mitogen-activated protein kinase-activated protein ki... 58 5e-08
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 57 6e-08
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 57 8e-08
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 56 1e-07
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 56 2e-07
gi|27901803 protein serine kinase H1 [Homo sapiens] 55 2e-07
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 55 3e-07
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 55 3e-07
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 55 4e-07
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 55 4e-07
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 55 4e-07
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens] 55 4e-07
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens] 55 4e-07
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 55 4e-07
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 54 5e-07
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 54 5e-07
>gi|47604944 SCY1-like 2 protein [Homo sapiens]
Length = 929
Score = 1851 bits (4794), Expect = 0.0
Identities = 929/929 (100%), Positives = 929/929 (100%)
Query: 1 MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQE 60
MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQE
Sbjct: 1 MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQE 60
Query: 61 VAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTE 120
VAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTE
Sbjct: 61 VAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTE 120
Query: 121 PVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNIT 180
PVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNIT
Sbjct: 121 PVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNIT 180
Query: 181 PENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILS 240
PENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILS
Sbjct: 181 PENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILS 240
Query: 241 VSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEV 300
VSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEV
Sbjct: 241 VSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEV 300
Query: 301 REHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVL 360
REHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVL
Sbjct: 301 REHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVL 360
Query: 361 PKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYVKLILPELGPVFKQQ 420
PKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYVKLILPELGPVFKQQ
Sbjct: 361 PKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYVKLILPELGPVFKQQ 420
Query: 421 EPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLID 480
EPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLID
Sbjct: 421 EPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLID 480
Query: 481 YPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEP 540
YPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEP
Sbjct: 481 YPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEP 540
Query: 541 AVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFNSFISVIKEMLN 600
AVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFNSFISVIKEMLN
Sbjct: 541 AVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFNSFISVIKEMLN 600
Query: 601 RLESEHKTKLEQLHIMQEQQKSLDIGNQMNVSEEMKVTNIGNQQIDKVFNNIGADLLTGS 660
RLESEHKTKLEQLHIMQEQQKSLDIGNQMNVSEEMKVTNIGNQQIDKVFNNIGADLLTGS
Sbjct: 601 RLESEHKTKLEQLHIMQEQQKSLDIGNQMNVSEEMKVTNIGNQQIDKVFNNIGADLLTGS 660
Query: 661 ESENKEDGLQNKHKRASLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPVATVKQTKDLT 720
ESENKEDGLQNKHKRASLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPVATVKQTKDLT
Sbjct: 661 ESENKEDGLQNKHKRASLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPVATVKQTKDLT 720
Query: 721 DTLMDNMSSLTSLSVSTPKSSASSTFTSVPSMGIGMMFSTPTDNTKRNLTNGLNANMGFQ 780
DTLMDNMSSLTSLSVSTPKSSASSTFTSVPSMGIGMMFSTPTDNTKRNLTNGLNANMGFQ
Sbjct: 721 DTLMDNMSSLTSLSVSTPKSSASSTFTSVPSMGIGMMFSTPTDNTKRNLTNGLNANMGFQ 780
Query: 781 TSGFNMPVNTNQNFYSSPSTVGVTKMTLGTPPTLPNFNALSVPPAGAKQTQQRPTDMSAL 840
TSGFNMPVNTNQNFYSSPSTVGVTKMTLGTPPTLPNFNALSVPPAGAKQTQQRPTDMSAL
Sbjct: 781 TSGFNMPVNTNQNFYSSPSTVGVTKMTLGTPPTLPNFNALSVPPAGAKQTQQRPTDMSAL 840
Query: 841 NNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPTMGSSVMGTQMNVIGQSAFGMQGNP 900
NNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPTMGSSVMGTQMNVIGQSAFGMQGNP
Sbjct: 841 NNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPTMGSSVMGTQMNVIGQSAFGMQGNP 900
Query: 901 FFNPQNFAQPPTTMTNSSSASNDLKDLFG 929
FFNPQNFAQPPTTMTNSSSASNDLKDLFG
Sbjct: 901 FFNPQNFAQPPTTMTNSSSASNDLKDLFG 929
>gi|115430243 SCY1-like 1 isoform B [Homo sapiens]
Length = 791
Score = 122 bits (307), Expect = 1e-27
Identities = 133/583 (22%), Positives = 246/583 (42%), Gaps = 65/583 (11%)
Query: 41 GGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPR 100
GG W + G KK+T V++FV+D K + E+ Q+ K ++ LRHP
Sbjct: 23 GGLPGPWALHRGRKKATGSPVSIFVYDVKPGAE----EQTQVA---KAAFKRFKTLRHPN 75
Query: 101 LLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQ 160
+L LE + CL TE V LG + + ++ L ++E +GL Q
Sbjct: 76 ILAYIDGLETEK-CLHVVTEAV-----TPLGIY------LKARVEAGGLKELEISWGLHQ 123
Query: 161 VSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDP 220
+ + LSFL + ++H N+ + ++++G WK+ G D+ S+ P+
Sbjct: 124 IVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPR-------K 176
Query: 221 NLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSR 280
+P L +P LA V + ++DM+ LG +++ VFN P
Sbjct: 177 GIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP--------------- 221
Query: 281 QLDQLSRLGSSSLTN---IPEEVREHVKLLLNVTPTVRPDAD---QMTKIP--FFDDVGA 332
+++L N IP+ + H L+ P VRP+ Q + P F +
Sbjct: 222 --------RAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFV 273
Query: 333 VTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPN 392
T + + + ++ +K +FF+ L K L P+ ++LP L + F + VL
Sbjct: 274 ETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTP 333
Query: 393 VLLIAEECTKEEYVKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPM 452
+ + + + EEY + I+P + +F + + + LQ+M+ + + + P
Sbjct: 334 LFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRL-LQQMEQFIQYLDEPTVNTQIFPH 392
Query: 453 VYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCL 512
V + I+E + + A ++ ++ L+ + +R N+ VCL
Sbjct: 393 VVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCL 452
Query: 513 GKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLP 572
GKI YL +L +++P + G+ TH + A K+LP
Sbjct: 453 GKIGSYLSA-STRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSM--NDCAQKILP 509
Query: 573 HLIPLSIENNLNLNQFNSFISVIKEMLNRLE--SEHKTKLEQL 613
L L+++ ++ + I+ L++LE SE T+LE++
Sbjct: 510 VLCGLTVDPEKSVR--DQAFKAIRSFLSKLESVSEDPTQLEEV 550
>gi|115430241 SCY1-like 1 isoform A [Homo sapiens]
Length = 808
Score = 122 bits (307), Expect = 1e-27
Identities = 133/583 (22%), Positives = 246/583 (42%), Gaps = 65/583 (11%)
Query: 41 GGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPR 100
GG W + G KK+T V++FV+D K + E+ Q+ K ++ LRHP
Sbjct: 23 GGLPGPWALHRGRKKATGSPVSIFVYDVKPGAE----EQTQVA---KAAFKRFKTLRHPN 75
Query: 101 LLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQ 160
+L LE + CL TE V LG + + ++ L ++E +GL Q
Sbjct: 76 ILAYIDGLETEK-CLHVVTEAV-----TPLGIY------LKARVEAGGLKELEISWGLHQ 123
Query: 161 VSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDP 220
+ + LSFL + ++H N+ + ++++G WK+ G D+ S+ P+
Sbjct: 124 IVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPR-------K 176
Query: 221 NLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSR 280
+P L +P LA V + ++DM+ LG +++ VFN P
Sbjct: 177 GIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP--------------- 221
Query: 281 QLDQLSRLGSSSLTN---IPEEVREHVKLLLNVTPTVRPDAD---QMTKIP--FFDDVGA 332
+++L N IP+ + H L+ P VRP+ Q + P F +
Sbjct: 222 --------RAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFV 273
Query: 333 VTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPN 392
T + + + ++ +K +FF+ L K L P+ ++LP L + F + VL
Sbjct: 274 ETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTP 333
Query: 393 VLLIAEECTKEEYVKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPM 452
+ + + + EEY + I+P + +F + + + LQ+M+ + + + P
Sbjct: 334 LFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRL-LQQMEQFIQYLDEPTVNTQIFPH 392
Query: 453 VYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCL 512
V + I+E + + A ++ ++ L+ + +R N+ VCL
Sbjct: 393 VVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCL 452
Query: 513 GKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLP 572
GKI YL +L +++P + G+ TH + A K+LP
Sbjct: 453 GKIGSYLSA-STRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSM--NDCAQKILP 509
Query: 573 HLIPLSIENNLNLNQFNSFISVIKEMLNRLE--SEHKTKLEQL 613
L L+++ ++ + I+ L++LE SE T+LE++
Sbjct: 510 VLCGLTVDPEKSVR--DQAFKAIRSFLSKLESVSEDPTQLEEV 550
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
+F++GR + G G ++ +K +K F+ K++ K Q EK + L+R V
Sbjct: 132 DFEIGRPLGKGKFG---NVYLAREKQSK-----FILALKVLFKAQ-LEKAGVEHQLRREV 182
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
+ + LRHP +L + ++ +A L V + L K
Sbjct: 183 EIQSHLRHPNILRLYGYFHDATRVYLILE---YAPLGTVYRELQKLS----------KFD 229
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
+ T + +++ LS+ HS +++H +I PEN++L +G KI F + V + PS +
Sbjct: 230 EQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRR 286
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
+LC +YL PE I + D++SLG + Y F GKP FE N
Sbjct: 287 ------------TTLC-GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEAN 332
Query: 271 K-QDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPF 326
Q+ YK ++SR+ + + E R+ + LL P+ RP ++ + P+
Sbjct: 333 TYQETYK-------RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW 382
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
+F++GR + G G ++ +K +K F+ K++ K Q EK + L+R V
Sbjct: 132 DFEIGRPLGKGKFG---NVYLAREKQSK-----FILALKVLFKAQ-LEKAGVEHQLRREV 182
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
+ + LRHP +L + ++ +A L V + L K
Sbjct: 183 EIQSHLRHPNILRLYGYFHDATRVYLILE---YAPLGTVYRELQKLS----------KFD 229
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
+ T + +++ LS+ HS +++H +I PEN++L +G KI F + V + PS +
Sbjct: 230 EQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRR 286
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
+LC +YL PE I + D++SLG + Y F GKP FE N
Sbjct: 287 ------------TTLC-GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEAN 332
Query: 271 K-QDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPF 326
Q+ YK ++SR+ + + E R+ + LL P+ RP ++ + P+
Sbjct: 333 TYQETYK-------RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW 382
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
+F++GR + G G ++ +K +K F+ K++ K Q EK + L+R V
Sbjct: 132 DFEIGRPLGKGKFG---NVYLAREKQSK-----FILALKVLFKAQ-LEKAGVEHQLRREV 182
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
+ + LRHP +L + ++ +A L V + L K
Sbjct: 183 EIQSHLRHPNILRLYGYFHDATRVYLILE---YAPLGTVYRELQKLS----------KFD 229
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
+ T + +++ LS+ HS +++H +I PEN++L +G KI F + V + PS +
Sbjct: 230 EQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRR 286
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
+LC +YL PE I + D++SLG + Y F GKP FE N
Sbjct: 287 ------------TTLC-GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEAN 332
Query: 271 K-QDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPF 326
Q+ YK ++SR+ + + E R+ + LL P+ RP ++ + P+
Sbjct: 333 TYQETYK-------RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW 382
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
+F++GR + G G ++ +K +K F+ K++ K Q EK + L+R V
Sbjct: 132 DFEIGRPLGKGKFG---NVYLAREKQSK-----FILALKVLFKAQ-LEKAGVEHQLRREV 182
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
+ + LRHP +L + ++ +A L V + L K
Sbjct: 183 EIQSHLRHPNILRLYGYFHDATRVYLILE---YAPLGTVYRELQKLS----------KFD 229
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
+ T + +++ LS+ HS +++H +I PEN++L +G KI F + V + PS +
Sbjct: 230 EQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRR 286
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
+LC +YL PE I + D++SLG + Y F GKP FE N
Sbjct: 287 ------------TTLC-GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEAN 332
Query: 271 K-QDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPF 326
Q+ YK ++SR+ + + E R+ + LL P+ RP ++ + P+
Sbjct: 333 TYQETYK-------RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW 382
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
+F++GR + G G ++ +K +K F+ K++ K Q EK + L+R V
Sbjct: 132 DFEIGRPLGKGKFG---NVYLAREKQSK-----FILALKVLFKAQ-LEKAGVEHQLRREV 182
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
+ + LRHP +L + ++ +A L V + L K
Sbjct: 183 EIQSHLRHPNILRLYGYFHDATRVYLILE---YAPLGTVYRELQKLS----------KFD 229
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
+ T + +++ LS+ HS +++H +I PEN++L +G KI F + V + PS +
Sbjct: 230 EQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRR 286
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
+LC +YL PE I + D++SLG + Y F GKP FE N
Sbjct: 287 ------------TTLC-GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEAN 332
Query: 271 K-QDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPF 326
Q+ YK ++SR+ + + E R+ + LL P+ RP ++ + P+
Sbjct: 333 TYQETYK-------RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW 382
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
+F++GR + G G ++ +K +K F+ K++ K Q EK + L+R V
Sbjct: 132 DFEIGRPLGKGKFG---NVYLAREKQSK-----FILALKVLFKAQ-LEKAGVEHQLRREV 182
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
+ + LRHP +L + ++ +A L V + L K
Sbjct: 183 EIQSHLRHPNILRLYGYFHDATRVYLILE---YAPLGTVYRELQKLS----------KFD 229
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
+ T + +++ LS+ HS +++H +I PEN++L +G KI F + V + PS +
Sbjct: 230 EQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRR 286
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
+LC +YL PE I + D++SLG + Y F GKP FE N
Sbjct: 287 ------------TTLC-GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEAN 332
Query: 271 K-QDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPF 326
Q+ YK ++SR+ + + E R+ + LL P+ RP ++ + P+
Sbjct: 333 TYQETYK-------RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW 382
>gi|170784850 SCY1-like 3 isoform 2 [Homo sapiens]
Length = 742
Score = 70.5 bits (171), Expect = 7e-12
Identities = 87/408 (21%), Positives = 162/408 (39%), Gaps = 60/408 (14%)
Query: 84 DSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPD 143
D + + + L LRHP LL E+ D + TE V P+
Sbjct: 48 DKVNKAAKHLKTLRHPCLLRFLSCTVEA-DGIHLVTERV---------------QPLEVA 91
Query: 144 IKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSS 203
++ L E G+ + L FLH + H N+ ++ +++ G WK+ G + +
Sbjct: 92 LET--LSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGME---TV 146
Query: 204 TNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCET-ASDMYSLGTVMYAVFNK 262
S+ P+F P+ +P PE ++PE+ C A D +S GT++ ++
Sbjct: 147 CKVSQATPEFLRSIQSIRDPA-SIP-PEEMSPEFTTLPECHGHARDAFSFGTLVESLLTI 204
Query: 263 GKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMT 322
+ E D+ SF + L LLN P RP +
Sbjct: 205 ---LNEQVSADVLSSFQQTLHST---------------------LLNPIPKCRPALCTLL 240
Query: 323 KIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSE--F 380
FF + + + +L + +K++FFK L + L + +I R++P L ++ F
Sbjct: 241 SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF 300
Query: 381 VNPDMVPFVLPNVLLIAEECTKEE---------YVKLILPELGPVFKQQEPIQILLIFLQ 431
P V LP +L ++ + E + ++P L +F+ E + ++ L
Sbjct: 301 AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEE-HVRMVLLS 359
Query: 432 KMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLI 479
++ + +++K +LP V L S I + L+ + +L+
Sbjct: 360 HIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLL 407
>gi|170784842 SCY1-like 3 isoform 1 [Homo sapiens]
Length = 688
Score = 70.5 bits (171), Expect = 7e-12
Identities = 87/408 (21%), Positives = 162/408 (39%), Gaps = 60/408 (14%)
Query: 84 DSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPD 143
D + + + L LRHP LL E+ D + TE V P+
Sbjct: 48 DKVNKAAKHLKTLRHPCLLRFLSCTVEA-DGIHLVTERV---------------QPLEVA 91
Query: 144 IKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSS 203
++ L E G+ + L FLH + H N+ ++ +++ G WK+ G + +
Sbjct: 92 LET--LSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGME---TV 146
Query: 204 TNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCET-ASDMYSLGTVMYAVFNK 262
S+ P+F P+ +P PE ++PE+ C A D +S GT++ ++
Sbjct: 147 CKVSQATPEFLRSIQSIRDPA-SIP-PEEMSPEFTTLPECHGHARDAFSFGTLVESLLTI 204
Query: 263 GKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMT 322
+ E D+ SF + L LLN P RP +
Sbjct: 205 ---LNEQVSADVLSSFQQTLHST---------------------LLNPIPKCRPALCTLL 240
Query: 323 KIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSE--F 380
FF + + + +L + +K++FFK L + L + +I R++P L ++ F
Sbjct: 241 SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF 300
Query: 381 VNPDMVPFVLPNVLLIAEECTKEE---------YVKLILPELGPVFKQQEPIQILLIFLQ 431
P V LP +L ++ + E + ++P L +F+ E + ++ L
Sbjct: 301 AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEE-HVRMVLLS 359
Query: 432 KMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLI 479
++ + +++K +LP V L S I + L+ + +L+
Sbjct: 360 HIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLL 407
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 61.2 bits (147), Expect = 4e-09
Identities = 71/298 (23%), Positives = 127/298 (42%), Gaps = 43/298 (14%)
Query: 30 REFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRG 89
R + GR + GG + + T T AV V + + K + EK +
Sbjct: 60 RTYLKGRLLGKGGFA---RCYEATDTETGSAYAVKVIPQSRVAKPHQREK------ILNE 110
Query: 90 VQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKL 149
++ L+H ++ H E++ + F SLA++ W+ + + P+++ Y
Sbjct: 111 IELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHI---WKARHTLLEPEVRYY-- 165
Query: 150 YDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQ 209
L Q+ GL +LH ++H ++ N + ++ K+ F + P EQ
Sbjct: 166 --------LRQILSGLKYLHQR-GILHRDLKLGNFFITENMELKVGDFGLA-ARLEPPEQ 215
Query: 210 EPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEV 269
K C P Y+APE +L +D++SLG VMY + G P FE
Sbjct: 216 RKKTICG------------TPNYVAPEVLLRQGHGPEADVWSLGCVMYTLL-CGSPPFET 262
Query: 270 NKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPFF 327
D+ +++ R + Q+ +SL ++P R+ + +L +P RP DQ+ + FF
Sbjct: 263 --ADLKETY-RCIKQVHYTLPASL-SLP--ARQLLAAILRASPRDRPSIDQILRHDFF 314
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 59.3 bits (142), Expect = 2e-08
Identities = 80/348 (22%), Positives = 137/348 (39%), Gaps = 65/348 (18%)
Query: 26 NPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDS 85
N +FD + I G G K+ +KS AV V KK I K +K+Q
Sbjct: 29 NAQPTDFDFLKVIGKGNYG---KVLLAKRKSDGAFYAVKVLQKKSILK----KKEQSHIM 81
Query: 86 LKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIK 145
+R V L +RHP L+ +++ + E ++ L V G L + +
Sbjct: 82 AERSVL-LKNVRHPFLVGLRYSFQTP--------EKLYFVLDYVNGG--ELFFHLQ---R 127
Query: 146 DYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTN 205
+ + + ++ +V+ + +LHS + +++ ++ PENI+L+ G + F C
Sbjct: 128 ERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVE 186
Query: 206 PSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKP 265
P + F PEYLAPE + + A D + LG V+Y + + P
Sbjct: 187 PEDTTSTF-------------CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPP 233
Query: 266 IFEVNKQDIYKSFSRQ---------------------LDQLSRLGSSSLTNIPEEVREHV 304
+ + +Y++ Q DQ RLGS + E++ HV
Sbjct: 234 FYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADF---LEIKNHV 290
Query: 305 KLLLNVTPTVRPDADQMTKIPFFDD--VGAVTLQYFDTLFQRDNLQKS 350
+P D P F+ G L++FD F ++ + KS
Sbjct: 291 FF----SPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKS 334
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 59.3 bits (142), Expect = 2e-08
Identities = 80/348 (22%), Positives = 137/348 (39%), Gaps = 65/348 (18%)
Query: 26 NPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDS 85
N +FD + I G G K+ +KS AV V KK I K +K+Q
Sbjct: 89 NAQPTDFDFLKVIGKGNYG---KVLLAKRKSDGAFYAVKVLQKKSILK----KKEQSHIM 141
Query: 86 LKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIK 145
+R V L +RHP L+ +++ + E ++ L V G L + +
Sbjct: 142 AERSVL-LKNVRHPFLVGLRYSFQTP--------EKLYFVLDYVNGG--ELFFHLQ---R 187
Query: 146 DYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTN 205
+ + + ++ +V+ + +LHS + +++ ++ PENI+L+ G + F C
Sbjct: 188 ERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVE 246
Query: 206 PSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKP 265
P + F PEYLAPE + + A D + LG V+Y + + P
Sbjct: 247 PEDTTSTF-------------CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPP 293
Query: 266 IFEVNKQDIYKSFSRQ---------------------LDQLSRLGSSSLTNIPEEVREHV 304
+ + +Y++ Q DQ RLGS + E++ HV
Sbjct: 294 FYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADF---LEIKNHV 350
Query: 305 KLLLNVTPTVRPDADQMTKIPFFDD--VGAVTLQYFDTLFQRDNLQKS 350
+P D P F+ G L++FD F ++ + KS
Sbjct: 351 FF----SPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKS 394
>gi|4758700 mitogen-activated protein kinase-activated protein
kinase 3 [Homo sapiens]
Length = 382
Score = 57.8 bits (138), Expect = 5e-08
Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 28/176 (15%)
Query: 161 VSEGLSFLHSSVKMVHGNITPENIILN---KSGAWKIMGFDFCVSSTNPSEQEPKFPCKE 217
+ + FLHS + H ++ PEN++ K K+ F F +T + Q P +
Sbjct: 150 IGTAIQFLHSH-NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCY---- 204
Query: 218 WDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKS 277
P Y+APE + + + DM+SLG +MY + P + Q I
Sbjct: 205 -----------TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG 253
Query: 278 FSRQLDQLSRLGSSSLTN-----IPEEVREHVKLLLNVTPTVRPDADQMTKIPFFD 328
R++ RLG N + E+ ++ ++LLL PT R Q P+ +
Sbjct: 254 MKRRI----RLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 305
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 57.4 bits (137), Expect = 6e-08
Identities = 62/233 (26%), Positives = 104/233 (44%), Gaps = 46/233 (19%)
Query: 30 REFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRG 89
+EF+ I G G+ ++ T + VA+ K +DK EKD I S R
Sbjct: 37 KEFEKLNRIGEGTYGI---VYRARDTQTDEIVAL---KKVRMDK----EKDGIPISSLRE 86
Query: 90 VQQLTRLRHPRL-----LTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDI 144
+ L RLRHP + + V + LE + +C + LA++L EN+P+P S
Sbjct: 87 ITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQ----DLASLL---ENMPTPFS--- 136
Query: 145 KDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSST 204
+ + K +LQV GL +LH + ++H ++ N+++ G K F
Sbjct: 137 ------EAQVKCIVLQVLRGLQYLHRNF-IIHRDLKVSNLLMTDKGCVKTADFGLA---- 185
Query: 205 NPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETAS-DMYSLGTVM 256
+ P K P + +L Y APE +L + +T S DM+++G ++
Sbjct: 186 ----RAYGVPVKPMTPKVVTLW-----YRAPELLLGTTTQTTSIDMWAVGCIL 229
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 57.0 bits (136), Expect = 8e-08
Identities = 58/254 (22%), Positives = 107/254 (42%), Gaps = 34/254 (13%)
Query: 28 VTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLK 87
V +++G + SG + K K + K+ A F+ ++L + +++I +
Sbjct: 9 VEDHYEMGEELGSGQFAIVRKCRQ--KGTGKEYAAKFIKKRRLSSSRRGVSREEI----E 62
Query: 88 RGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDY 147
R V L +RHP ++T+ E D + L + L E+L
Sbjct: 63 REVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTE--------- 113
Query: 148 KLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAW--KIMGFDFCVSSTN 205
D T++ L Q+ +G+ +LHS ++ H ++ PENI+L +I DF ++
Sbjct: 114 ---DEATQF-LKQILDGVHYLHSK-RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKI 168
Query: 206 PSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKP 265
+ E K N+ PE++APE + +DM+S+G + Y + + P
Sbjct: 169 EAGNEFK--------NI----FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 216
Query: 266 IFEVNKQDIYKSFS 279
KQ+ + S
Sbjct: 217 FLGETKQETLTNIS 230
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/233 (24%), Positives = 105/233 (45%), Gaps = 43/233 (18%)
Query: 38 IASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLK-RGVQQLTRL 96
+ G G+ K N K T + VA I K+ + + D+++ + R ++ L +L
Sbjct: 10 VGEGSYGMVMKCRN---KDTGRIVA--------IKKFLESDDDKMVKKIAMREIKLLKQL 58
Query: 97 RHPRLLTVQHPLEESRDCLAFCTEPVFASLAN-VLGNWENLPSPISPDIKDYKLYDVETK 155
RH L+ + ++ + VF + + +L + E P+ + Y V K
Sbjct: 59 RHENLVNLLEVCKKKKRWYL-----VFEFVDHTILDDLELFPNGLD--------YQVVQK 105
Query: 156 YGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPC 215
Y L Q+ G+ F HS ++H +I PENI++++SG K+ F F + P E +
Sbjct: 106 Y-LFQIINGIGFCHSH-NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVA 163
Query: 216 KEWDPNLPSLCLPNPEYLAPEYIL-SVSCETASDMYSLGTVMYAVFNKGKPIF 267
W Y APE ++ V A D++++G ++ +F G+P+F
Sbjct: 164 TRW-------------YRAPELLVGDVKYGKAVDVWAIGCLVTEMF-MGEPLF 202
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 55.8 bits (133), Expect = 2e-07
Identities = 51/217 (23%), Positives = 99/217 (45%), Gaps = 37/217 (17%)
Query: 42 GNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRL 101
G G +++ G +K + Q VA+ K I K + EK+ + +L+R ++ + LRHP +
Sbjct: 11 GEGSFGRVYKGRRKYSAQVVAL-----KFIPKLGRSEKE--LRNLQREIEIMRGLRHPNI 63
Query: 102 LTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQV 161
+ + E ++ + T+ L +L + D KL + + + Q+
Sbjct: 64 VHMLDSFETDKEVVVV-TDYAEGELFQILED-------------DGKLPEDQVQAIAAQL 109
Query: 162 SEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFC-VSSTNPSEQEPKFPCKEWDP 220
L +LHS +++H ++ P+NI+L K G K+ F F STN
Sbjct: 110 VSALYYLHSH-RILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTM------------- 155
Query: 221 NLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMY 257
+ + P Y++PE + + +D++S+G ++Y
Sbjct: 156 -VLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILY 191
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 55.5 bits (132), Expect = 2e-07
Identities = 45/176 (25%), Positives = 81/176 (46%), Gaps = 15/176 (8%)
Query: 158 LLQVSEGLSFLHSSVKMVHGNITPENIILNKSGA-WKIMGFDFCVSSTNPSEQEPKFPCK 216
L V +G+ +LH+ + + H ++ PEN++ G KI+ DF ++S K
Sbjct: 199 LQMVLDGVRYLHA-LGITHRDLKPENLLYYHPGTDSKIIITDFGLASAR----------K 247
Query: 217 EWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYK 276
+ D L PEY+APE ++ + DM++LG + Y + + P + N+ +Y+
Sbjct: 248 KGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYR 307
Query: 277 SFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGA 332
R S S++N+ ++ + LL V P R A Q + P+ + A
Sbjct: 308 QILRGKYSYSGEPWPSVSNL---AKDFIDRLLTVDPGARMTALQALRHPWVVSMAA 360
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 15/135 (11%)
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
D T++ V E ++LHS +++ ++ PEN+IL+ G K++ F F ++
Sbjct: 458 DSTTRFYTACVVEAFAYLHSK-GIIYRDLKPENLILDHRGYAKLVDFGFA--------KK 508
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
F K W + C PEY+APE IL+ + ++D +SLG +MY + P +
Sbjct: 509 IGFGKKTW-----TFC-GTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD 562
Query: 271 KQDIYKSFSRQLDQL 285
Y R +D +
Sbjct: 563 PMKTYNIILRGIDMI 577
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 15/135 (11%)
Query: 151 DVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQE 210
D T++ V E ++LHS +++ ++ PEN+IL+ G K++ F F ++
Sbjct: 473 DSTTRFYTACVVEAFAYLHSK-GIIYRDLKPENLILDHRGYAKLVDFGFA--------KK 523
Query: 211 PKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVN 270
F K W + C PEY+APE IL+ + ++D +SLG +MY + P +
Sbjct: 524 IGFGKKTW-----TFC-GTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPD 577
Query: 271 KQDIYKSFSRQLDQL 285
Y R +D +
Sbjct: 578 PMKTYNIILRGIDMI 592
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 54.7 bits (130), Expect = 4e-07
Identities = 71/317 (22%), Positives = 126/317 (39%), Gaps = 45/317 (14%)
Query: 10 STVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKK 69
+T + +S M +F++GR + G G ++ K + VA+ V K
Sbjct: 2 ATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFG---NVYLARLKESHFIVALKVLFKS 58
Query: 70 LIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANV 129
I EK+ + L+R ++ L+HP +L + + ++R L
Sbjct: 59 QI------EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKE 112
Query: 130 LGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKS 189
L K KL + T + ++++ L++ H K++H +I PEN++L
Sbjct: 113 LQ-------------KSEKLDEQRTATIIEELADALTYCHDK-KVIHRDIKPENLLLGFR 158
Query: 190 GAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDM 249
G KI F + V + PS + K C D YL PE I + + D+
Sbjct: 159 GEVKIADFGWSVHT--PSLRR-KTMCGTLD------------YLPPEMIEGRTYDEKVDL 203
Query: 250 YSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLN 309
+ +G + Y + G P FE S S ++ ++ ++P R+ + LL
Sbjct: 204 WCIGVLCYELL-VGYPPFE------SASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 256
Query: 310 VTPTVRPDADQMTKIPF 326
P R Q+ K P+
Sbjct: 257 YQPLERLPLAQILKHPW 273
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 54.7 bits (130), Expect = 4e-07
Identities = 71/317 (22%), Positives = 126/317 (39%), Gaps = 45/317 (14%)
Query: 10 STVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKK 69
+T + +S M +F++GR + G G ++ K + VA+ V K
Sbjct: 21 ATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFG---NVYLARLKESHFIVALKVLFKS 77
Query: 70 LIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANV 129
I EK+ + L+R ++ L+HP +L + + ++R L
Sbjct: 78 QI------EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKE 131
Query: 130 LGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKS 189
L K KL + T + ++++ L++ H K++H +I PEN++L
Sbjct: 132 LQ-------------KSEKLDEQRTATIIEELADALTYCHDK-KVIHRDIKPENLLLGFR 177
Query: 190 GAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDM 249
G KI F + V + PS + K C D YL PE I + + D+
Sbjct: 178 GEVKIADFGWSVHT--PSLRR-KTMCGTLD------------YLPPEMIEGRTYDEKVDL 222
Query: 250 YSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLN 309
+ +G + Y + G P FE S S ++ ++ ++P R+ + LL
Sbjct: 223 WCIGVLCYELL-VGYPPFE------SASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 275
Query: 310 VTPTVRPDADQMTKIPF 326
P R Q+ K P+
Sbjct: 276 YQPLERLPLAQILKHPW 292
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 54.7 bits (130), Expect = 4e-07
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 36/185 (19%)
Query: 78 EKDQIIDSLKRGVQQLTRLRHPRL-----LTVQHPLEESRDCLAFCTEPVFASLANVLGN 132
EKD I S R + L RLRHP + + V + LE + +C + LA++L
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQ----DLASLL-- 57
Query: 133 WENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAW 192
EN+P+P S + + K +LQV GL +LH + ++H ++ N+++ G
Sbjct: 58 -ENMPTPFS---------EAQVKCIVLQVLRGLQYLHRNF-IIHRDLKVSNLLMTDKGCV 106
Query: 193 KIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETAS-DMYS 251
K F + P K P + +L Y APE +L + +T S DM++
Sbjct: 107 KTADFGLA--------RAYGVPVKPMTPKVVTLW-----YRAPELLLGTTTQTTSIDMWA 153
Query: 252 LGTVM 256
+G ++
Sbjct: 154 VGCIL 158
>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
Length = 283
Score = 54.7 bits (130), Expect = 4e-07
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 36/185 (19%)
Query: 78 EKDQIIDSLKRGVQQLTRLRHPRL-----LTVQHPLEESRDCLAFCTEPVFASLANVLGN 132
EKD I S R + L RLRHP + + V + LE + +C + LA++L
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQ----DLASLL-- 57
Query: 133 WENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAW 192
EN+P+P S + + K +LQV GL +LH + ++H ++ N+++ G
Sbjct: 58 -ENMPTPFS---------EAQVKCIVLQVLRGLQYLHRNF-IIHRDLKVSNLLMTDKGCV 106
Query: 193 KIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETAS-DMYS 251
K F + P K P + +L Y APE +L + +T S DM++
Sbjct: 107 KTADFGLA--------RAYGVPVKPMTPKVVTLW-----YRAPELLLGTTTQTTSIDMWA 153
Query: 252 LGTVM 256
+G ++
Sbjct: 154 VGCIL 158
>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
Length = 272
Score = 54.7 bits (130), Expect = 4e-07
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 36/185 (19%)
Query: 78 EKDQIIDSLKRGVQQLTRLRHPRL-----LTVQHPLEESRDCLAFCTEPVFASLANVLGN 132
EKD I S R + L RLRHP + + V + LE + +C + LA++L
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQ----DLASLL-- 57
Query: 133 WENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAW 192
EN+P+P S + + K +LQV GL +LH + ++H ++ N+++ G
Sbjct: 58 -ENMPTPFS---------EAQVKCIVLQVLRGLQYLHRNF-IIHRDLKVSNLLMTDKGCV 106
Query: 193 KIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETAS-DMYS 251
K F + P K P + +L Y APE +L + +T S DM++
Sbjct: 107 KTADFGLA--------RAYGVPVKPMTPKVVTLW-----YRAPELLLGTTTQTTSIDMWA 153
Query: 252 LGTVM 256
+G ++
Sbjct: 154 VGCIL 158
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/303 (21%), Positives = 122/303 (40%), Gaps = 46/303 (15%)
Query: 31 EFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGV 90
++DV + I G G A+ + G S + F+K I + + +K+ I+
Sbjct: 3 KYDVIKAIGQGAFGKAY-LAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVIL------- 54
Query: 91 QQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLY 150
L +++HP ++ + +E+ L + + L+
Sbjct: 55 --LEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGV------------LF 100
Query: 151 DVETKYG-LLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQ 209
+ G +Q+S GL +H K++H +I +NI L+K+G +G DF ++ +
Sbjct: 101 SEDQILGWFVQISLGLKHIHDR-KILHRDIKAQNIFLSKNGMVAKLG-DFGIARVLNNSM 158
Query: 210 EPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEV 269
E L C+ P YL+PE + +D++SLG V+Y + P FE
Sbjct: 159 E-----------LARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHP-FEG 206
Query: 270 N--KQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPFF 327
N +Q + K +S E+ + L V+P RP + + K PF
Sbjct: 207 NNLQQLVLKICQAHFAPIS-------PGFSRELHSLISQLFQVSPRDRPSINSILKRPFL 259
Query: 328 DDV 330
+++
Sbjct: 260 ENL 262
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 54.3 bits (129), Expect = 5e-07
Identities = 55/235 (23%), Positives = 101/235 (42%), Gaps = 33/235 (14%)
Query: 42 GNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRL 101
G G K+ +K++ + A+ + K++I KD++ +L + L RHP L
Sbjct: 155 GKGTFGKVILVREKASGKYYAMKILKKEVI-----IAKDEVAHTLTES-RVLKNTRHPFL 208
Query: 102 LTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQV 161
++++ + ++D L F E V N L +S ++ + T++ ++
Sbjct: 209 TSLKYSFQ-TKDRLCFVMEYV---------NGGELFFHLS---RERVFSEDRTRFYGAEI 255
Query: 162 SEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPN 221
L +LHS K+V+ ++ EN++L+K G KI F C + F
Sbjct: 256 VSALDYLHSG-KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTF-------- 306
Query: 222 LPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYK 276
PEYLAPE + A D + LG VMY + P + + + +++
Sbjct: 307 -----CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 356
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 54.3 bits (129), Expect = 5e-07
Identities = 55/235 (23%), Positives = 101/235 (42%), Gaps = 33/235 (14%)
Query: 42 GNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRL 101
G G K+ +K++ + A+ + K++I KD++ +L + L RHP L
Sbjct: 155 GKGTFGKVILVREKASGKYYAMKILKKEVI-----IAKDEVAHTLTES-RVLKNTRHPFL 208
Query: 102 LTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQV 161
++++ + ++D L F E V N L +S ++ + T++ ++
Sbjct: 209 TSLKYSFQ-TKDRLCFVMEYV---------NGGELFFHLS---RERVFSEDRTRFYGAEI 255
Query: 162 SEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPN 221
L +LHS K+V+ ++ EN++L+K G KI F C + F
Sbjct: 256 VSALDYLHSG-KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTF-------- 306
Query: 222 LPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYK 276
PEYLAPE + A D + LG VMY + P + + + +++
Sbjct: 307 -----CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 356
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,298,340
Number of Sequences: 37866
Number of extensions: 1679983
Number of successful extensions: 7634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 587
Number of HSP's that attempted gapping in prelim test: 6806
Number of HSP's gapped (non-prelim): 1202
length of query: 929
length of database: 18,247,518
effective HSP length: 112
effective length of query: 817
effective length of database: 14,006,526
effective search space: 11443331742
effective search space used: 11443331742
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.