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Search of human proteins with 4759208
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
(1049 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 2078 0.0
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 1476 0.0
gi|45439370 TAO kinase 1 [Homo sapiens] 1426 0.0
gi|148746218 TAO kinase 3 [Homo sapiens] 1186 0.0
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 246 1e-64
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 228 3e-59
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 228 3e-59
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 228 3e-59
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 228 3e-59
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 227 5e-59
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 227 5e-59
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 227 5e-59
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 225 2e-58
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 222 1e-57
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 222 1e-57
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 221 2e-57
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 221 2e-57
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 221 4e-57
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 218 3e-56
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 214 4e-55
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 210 5e-54
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 207 4e-53
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 207 4e-53
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 207 4e-53
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 207 4e-53
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 207 5e-53
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 206 1e-52
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 206 1e-52
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 206 1e-52
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 199 1e-50
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 2078 bits (5383), Expect = 0.0
Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
Sbjct: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
Query: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
Sbjct: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
Sbjct: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
Sbjct: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
Query: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
Sbjct: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
Query: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
Sbjct: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
Query: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
Sbjct: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
Sbjct: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
Query: 721 NKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQ 780
NKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQ
Sbjct: 721 NKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQ 780
Query: 781 HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL 840
HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL
Sbjct: 781 HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL 840
Query: 841 NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA 900
NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA
Sbjct: 841 NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA 900
Query: 901 REIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPP 960
REIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPP
Sbjct: 901 REIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPP 960
Query: 961 GMPPPAWRQPSLLAPPGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVG 1020
GMPPPAWRQPSLLAPPGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVG
Sbjct: 961 GMPPPAWRQPSLLAPPGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVG 1020
Query: 1021 PPAAAVPGPLSRSTSVASHILNGSSHFYS 1049
PPAAAVPGPLSRSTSVASHILNGSSHFYS
Sbjct: 1021 PPAAAVPGPLSRSTSVASHILNGSSHFYS 1049
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 1476 bits (3822), Expect = 0.0
Identities = 744/744 (100%), Positives = 744/744 (100%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
Sbjct: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
Query: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
Sbjct: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
Sbjct: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
Sbjct: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
Query: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
Sbjct: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
Query: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
Sbjct: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
Query: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
Sbjct: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
Sbjct: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
Query: 721 NKRREQELRQKHAAQVRQQPKSLK 744
NKRREQELRQKHAAQVRQQPKSLK
Sbjct: 721 NKRREQELRQKHAAQVRQQPKSLK 744
Score = 35.4 bits (80), Expect = 0.28
Identities = 71/333 (21%), Positives = 131/333 (39%), Gaps = 56/333 (16%)
Query: 696 QAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQK---HAAQVRQQPKSLKSKELQIKK 752
+A R R ++ + + Q++ +++ + LR++ + RQ K L + E +++
Sbjct: 457 RAYCRNRDHFATIRTASLVSRQIQEHEQ-DSALREQLSGYKRMRRQHQKQLLALESRLRG 515
Query: 753 QFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLS 812
+ +E R+ +A RA K + + + E++ R ++ Q I
Sbjct: 516 EREEHSARLQRELEAQRAGFGAEAEKLARRH--QAIGEKEARAAQAEERKFQQHILGQQK 573
Query: 813 SQALRLDETQEAEFQALRQQLQQELE-------------LLNAYQSKIKIRTESQ----- 854
+ L E Q+ ++ ++QL++EL+ LL + + + E +
Sbjct: 574 KELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLR 633
Query: 855 HERELRELEQRVALRRALLEQR-VEEELL---------------ALQTGRSERIRSLLER 898
+R+ EL+ R R+ LL + ++++LL AL + E R L R
Sbjct: 634 RQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELR 693
Query: 899 QAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPP 958
Q + ++ AE RL + G E + A R P+S G
Sbjct: 694 QLQAVQRTRAELTRLQHQTEL--GNQLEYNKRREQELRQKHAAQVRQQPKS-LKVRAGQR 750
Query: 959 PPGMPPPAWRQPSLLAPPGPPNWLGPPTQSGTP 991
PPG+P P P LGPP +GTP
Sbjct: 751 PPGLPLPI------------PGALGPP-NTGTP 770
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 1426 bits (3691), Expect = 0.0
Identities = 739/1050 (70%), Positives = 843/1050 (80%), Gaps = 50/1050 (4%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
MP+ RAGSLKDP++AELFFK+DPEKLF+DLREIGHGSFGAVYFARDVR +EVVAIKKMS
Sbjct: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
Query: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQS EKWQDIIKEV+FLQ+++HPN+I+Y+GCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
KPLQEVEIAA+THGALQGLAYLHSH MIHRD+KAGNILL+EPG VKL DFGSAS+ +PAN
Sbjct: 121 KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
ESP LQS WS+YFRNFVDSCLQKIPQDRPTSE LLKH FVLRERP TV++DLIQRTKDA
Sbjct: 241 ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
VRELDNLQYRKMKK+LFQEA NGP EA EEEEE + + R GT+ S+ S+ S+PSMSIS
Sbjct: 301 VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS 360
Query: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
ASSQSSSVNSL D SD++ E + M EG+HTV S+SS+IH P
Sbjct: 361 ASSQSSSVNSLPDVSDDKSELD-------------------MMEGDHTVMSNSSVIHLKP 401
Query: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
+N Y+ E P A P S +R +++ RNR+HFATIRTASLV+RQ+Q
Sbjct: 402 EEEN-----YREEGDPRT----RASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQ 452
Query: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
EHEQDS LREQ+SGYKRMRRQHQKQL+ LE++L+ E +EH RL ++LE QR F AE E
Sbjct: 453 EHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEME 512
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
KL ++HQA EKEA+ EE+KFQQHI QQKKEL + LE+QKR YKLRKEQLKEEL E
Sbjct: 513 KLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNE 572
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
N STPK+EK EWL +QKE +Q QAEEEA LLRRQRQY EL+CR++KR+MLL RH+L+QD
Sbjct: 573 NQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQD 632
Query: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
L+RE+LNK+QTQKDLE A+LLRQHE+ +ELE R L +Q+ R EL RLQHQTEL NQLEY
Sbjct: 633 LVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEY 692
Query: 721 NKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQ 780
NKRRE+ELR+KH +VRQQPKSLKSKELQIKKQFQ+TCKIQTRQYKALR HLLETTPK++
Sbjct: 693 NKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSE 752
Query: 781 HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL 840
HK++LKRLKEEQTRKLAILAEQYD SI+EMLS+QALRLDE QEAE Q L+ QLQQELELL
Sbjct: 753 HKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELL 812
Query: 841 NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA 900
NAYQSKIK++ E+QH+RELRELEQRV+LRRALLEQ++EEE+LALQ R+ERIRSLLERQA
Sbjct: 813 NAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQA 872
Query: 901 REIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPP 960
REIEAFD+ESMRLGFS+M L + EA + YP A W P G HW H P
Sbjct: 873 REIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPG---ASGWSHNPTGGPGPHWGH---PM 926
Query: 961 GMPPPAWRQPSLLAPPGPPNWLGPP-TQSGTPRGGALLLLRNSPQPLRRAASGGSGSENV 1019
G PP AW P GP W P G PRG + + +RNSPQ LRR ASGG +
Sbjct: 927 GGPPQAWGHP---MQGGPQPWGHPSGPMQGVPRGSS-MGVRNSPQALRRTASGGRTEQG- 981
Query: 1020 GPPAAAVPGPLSRSTSVASHILNGSSHFYS 1049
+SRSTSV S I NGS Y+
Sbjct: 982 ----------MSRSTSVTSQISNGSHMSYT 1001
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 1186 bits (3069), Expect = 0.0
Identities = 598/921 (64%), Positives = 736/921 (79%), Gaps = 27/921 (2%)
Query: 6 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65
R G LKDP++A+LF+KDDPE+LF L EIGHGSFGAVYFA + SEVVAIKKMSYSGKQ
Sbjct: 2 RKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQ 61
Query: 66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 125
++EKWQDI+KEV+FL++L+HPNTI+Y+GCYL+EHTAWLVMEYCLGSASDLLEVHKKPLQE
Sbjct: 62 THEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQE 121
Query: 126 VEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGT 185
VEIAA+THGAL GLAYLHSH +IHRD+KAGNILL+EPG VKL DFGSAS+ +PANSFVGT
Sbjct: 122 VEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 181
Query: 186 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL 245
PYWMAPEVILAMDEGQYDGKVD+WSLGITCIELAERKPPLFNMNAMSALYHIAQN+SP L
Sbjct: 182 PYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL 241
Query: 246 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELD 305
QS W++ FR FVD CLQKIPQ+RPTS LL+H FV R+RP V++DLIQRTKDAVRELD
Sbjct: 242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELD 301
Query: 306 NLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQS 365
NLQYRKMKKILFQE NGP E+ E+EE++E + SL S+HS+PSMS+S SQS
Sbjct: 302 NLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361
Query: 366 SSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNL 425
SSVNS+ + D E + MM + E T+ S SS++H+ D++
Sbjct: 362 SSVNSMQEVMDESSSE-----------------LVMMHDDESTINSSSSVVHK---KDHV 401
Query: 426 YDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQD 485
+ P P P PT + S + + RNR+ FATI++ASLV+RQI EHEQ+
Sbjct: 402 FIRDEAGHGDPRP-----EPRPTQSVQS--QALHYRNRERFATIKSASLVTRQIHEHEQE 454
Query: 486 SALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARR 545
+ LREQ+SGYKRMRRQHQKQL+ALE++L+ E +EH +LQ+E+E E EKLA++
Sbjct: 455 NELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKK 514
Query: 546 HQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTP 605
AI EKEA+ A A+E+KFQQ IL QQKK+L LE+QK+ YK+ KE++KEE+ E+ STP
Sbjct: 515 QVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTP 574
Query: 606 KREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLRED 665
K+EK E + + KE LQ QAEEEA LL +QR Y++ CR +KRK+++ RH ++Q +RE+
Sbjct: 575 KKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREE 634
Query: 666 LNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRRE 725
LNKK+TQK++E A+L+R E+TRELE RQL +Q+ R +L RLQHQTEL NQLEYNKRRE
Sbjct: 635 LNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRE 694
Query: 726 QELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLL 785
+EL +KH ++RQQPK+LK+ E+QIKKQFQ+TCK+QT+QYKAL+ H LE TPK +HK++L
Sbjct: 695 RELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTIL 754
Query: 786 KRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQS 845
K LK+EQTRKLAILAEQY+QSI+EM++SQALRLDE QEAE QALR QLQQE+ELLNAYQS
Sbjct: 755 KTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQS 814
Query: 846 KIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEA 905
KIK++TE+QHEREL++LEQRV+LRRA LEQ++EEEL ALQ RSERI++LLERQ REIE
Sbjct: 815 KIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIET 874
Query: 906 FDAESMRLGFSSMALGGIPAE 926
FD ES+R+GF ++ P E
Sbjct: 875 FDMESLRMGFGNLVTLDFPKE 895
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 246 bits (627), Expect = 1e-64
Identities = 241/944 (25%), Positives = 415/944 (43%), Gaps = 150/944 (15%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DP +++ + E+G G+FG VY A++ + A K + +S E+ +D I E+ L
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAY 141
HP ++ G Y + W+++E+C G A D + + + L E +I V L+ L +
Sbjct: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS----IMAPANSFVGTPYWMAPEVILA- 196
LHS +IHRD+KAGN+L++ G ++L DFG ++ + +SF+GTPYWMAPEV++
Sbjct: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
Query: 197 -MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQS-GHWSEYF 254
M + YD K D+WSLGIT IE+A+ +PP +N M L IA+++ P L + WS F
Sbjct: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
Query: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFV--------LRE---RPPTVIMDLIQRTKDAVRE 303
R+F+ L K P+ RP++ LL+H FV LRE +M+ I+ +D E
Sbjct: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEE 327
Query: 304 LDNLQYRKMKKILFQEA----PNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSI 359
D + + Q + P A+ P EE + P + + + S+ S PS
Sbjct: 328 EDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTP-LAPSQSQDSVNEPCSQPSGDR 386
Query: 360 SASSQSSSVNSLADASDN----------------EEEEEEEEEEEEEEEGPEAREMAMMQ 403
S + S V +A ++N + + +E++ E+G + A
Sbjct: 387 SLQTTSPPV--VAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRS 444
Query: 404 EGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPA--APAPTSTTSSARRRAYCR 461
+ +SS + L G ++ L+PPA AP P+ S
Sbjct: 445 QKASQSRPNSSALETLGGE----------KLANGSLEPPAQAAPGPSKRDSDCSSLCTSE 494
Query: 462 NRDHFA----------------------------------------TIRTASLVSRQIQE 481
+ D+ +I T+ ++S ++
Sbjct: 495 SMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKK 554
Query: 482 HEQDSALREQ-LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
E+ LR Q L + ++++ + L ++ + E+ R ++E+ A++ F E E
Sbjct: 555 DEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELE 614
Query: 541 KLARRHQAIGEK-----------EARAAQAEE----RKFQQHILGQQKKELAALLEAQKR 585
L R+ + EK EAR + E+ +FQ+ L KKE+ E +K
Sbjct: 615 NLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQ-LKLMKKEVKN--EVEKL 671
Query: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQ 645
+ RKE +K++++E+ + +++ +QKE L+ RR+ E +C
Sbjct: 672 PRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDN-RREICDKERECLM 730
Query: 646 YKRKMLLARHSLDQDLLREDLNK-----KQTQKD---LECALLLRQHEATRELELRQLQA 697
K+++L R + ++ L + KQ KD L+ LLR+HE RE R Q
Sbjct: 731 KKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQR 790
Query: 698 V--------QRTRAELTRLQHQTELGNQLEYNKRRE-------QELRQKHAAQVRQQPKS 742
+ Q+ +A L ++Q Y K E R+K +Q+ K
Sbjct: 791 MIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKR 850
Query: 743 LKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQ 802
KS+ LQ +++ + + Q ++ + L + + H L E +T+KL L E
Sbjct: 851 QKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL-----LVEHETQKLKALDES 905
Query: 803 YDQSISEMLS-----SQALRLDETQEAEFQALRQQLQQELELLN 841
++Q++ E +AL D Q+ Q + +L +E E N
Sbjct: 906 HNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPN 949
Score = 37.4 bits (85), Expect = 0.075
Identities = 29/129 (22%), Positives = 62/129 (48%), Gaps = 21/129 (16%)
Query: 781 HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL 840
+K LKR TRK + + + S+++S DE ++ E + LR+Q +EL LL
Sbjct: 523 YKKTLKR-----TRKFVVDGVEVSITTSKIISE-----DEKKDEEMRFLRRQELRELRLL 572
Query: 841 NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA 900
+ + + + ++HE +L + + +R E+E+ A + + +L +Q
Sbjct: 573 QKEEHRNQTQLSNKHELQLEQ-----------MHKRFEQEINAKKKFFDTELENLERQQK 621
Query: 901 REIEAFDAE 909
+++E + +
Sbjct: 622 QQVEKMEQD 630
Score = 35.8 bits (81), Expect = 0.22
Identities = 36/172 (20%), Positives = 82/172 (47%), Gaps = 20/172 (11%)
Query: 741 KSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKA-----QHKSLLKRLKEEQTRK 795
K + S ++ K +++T K +TR++ + TT K + ++ L+ ++ R+
Sbjct: 510 KEMGSLSIKDPKLYKKTLK-RTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRE 568
Query: 796 LAILAEQYDQSISEMLSSQALRLDETQ---EAEFQALRQQLQQELELLNAYQSKIKIRTE 852
L +L ++ ++ +++ + L+L++ E E A ++ ELE L E
Sbjct: 569 LRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENL-----------E 617
Query: 853 SQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIE 904
Q ++++ ++EQ A+RR +R+ E T E+++ + + E+E
Sbjct: 618 RQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVE 669
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 228 bits (580), Expect = 3e-59
Identities = 202/677 (29%), Positives = 317/677 (46%), Gaps = 121/677 (17%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAI 549
+ + Q+Q L+ +L+ ER+ +H + QR +E + E + + + I
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 550 GEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR 607
A +Q Q + Q K L+ EA T Q + ENP P R
Sbjct: 538 PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTR 597
Query: 608 ----EKAEWLLRQKEQL 620
+++ W LRQ+E +
Sbjct: 598 IEKFDRSSW-LRQEEDI 613
Score = 58.2 bits (139), Expect = 4e-08
Identities = 79/359 (22%), Positives = 147/359 (40%), Gaps = 51/359 (14%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ E + ++R EE+ R+L IL +Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLL 466
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
+ +L + +L+E ++AE L++QL+QE + L QH+R+ EQ
Sbjct: 467 HEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYL----------VSLQHQRQ----EQ 510
Query: 865 RVALRRALLEQRV----------EEELLALQTGRSE-----RIRSLLERQAREIEAFDAE 909
R ++ L + +E+ L +S+ +S+ E+ + + F
Sbjct: 511 RPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQ-- 568
Query: 910 SMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQ 969
++ + E Q P P+R + W +PP ++
Sbjct: 569 ------EALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLR--QEEDIPPKVPQR 620
Query: 970 PSLLAP-------PGPPNWLGPPTQSGTPRGGALLLLRNSP---QPLRRAASGGSGSEN 1018
+ ++P PG + LGP S R L R P PL+R +SG S S +
Sbjct: 621 TTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSS 679
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 19/167 (11%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL 631
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 44.3 bits (103), Expect = 6e-04
Identities = 51/222 (22%), Positives = 91/222 (40%), Gaps = 38/222 (17%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEE---AGLLRRQRQYFELQCRQYKRKMLLA 653
+ + +RE+ +++ + Q EEE +L++Q + + +YKRK
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK---- 478
Query: 654 RHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQL 695
L++ E L ++ Q+ L Q + R +E + L
Sbjct: 479 --QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/198 (24%), Positives = 91/198 (45%), Gaps = 12/198 (6%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKE-QLQQCQAEEEAGLLRRQRQYFELQCRQ 645
Y +E+ +E PS+ E LR+ +LQ E L R+Q + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAEL 705
+KR++L R ++ +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEE-QKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEER 437
Query: 706 TRLQHQTE-LGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQ 764
R +H+ E + QLE +R+ + L+Q+ + +Q L+ K Q+++Q Q ++Q RQ
Sbjct: 438 RRAEHEQEYIRRQLEEEQRQLEILQQQ---LLHEQALLLEYKRKQLEEQRQAE-RLQ-RQ 492
Query: 765 YKALRAHLLETTPKAQHK 782
K R +L+ + Q +
Sbjct: 493 LKQERDYLVSLQHQRQEQ 510
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 228 bits (580), Expect = 3e-59
Identities = 202/677 (29%), Positives = 317/677 (46%), Gaps = 121/677 (17%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAI 549
+ + Q+Q L+ +L+ ER+ +H + QR +E + E + + + I
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 550 GEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR 607
A +Q Q + Q K L+ EA T Q + ENP P R
Sbjct: 538 PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTR 597
Query: 608 ----EKAEWLLRQKEQL 620
+++ W LRQ+E +
Sbjct: 598 IEKFDRSSW-LRQEEDI 613
Score = 58.2 bits (139), Expect = 4e-08
Identities = 79/359 (22%), Positives = 147/359 (40%), Gaps = 51/359 (14%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ E + ++R EE+ R+L IL +Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLL 466
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
+ +L + +L+E ++AE L++QL+QE + L QH+R+ EQ
Sbjct: 467 HEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYL----------VSLQHQRQ----EQ 510
Query: 865 RVALRRALLEQRV----------EEELLALQTGRSE-----RIRSLLERQAREIEAFDAE 909
R ++ L + +E+ L +S+ +S+ E+ + + F
Sbjct: 511 RPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQ-- 568
Query: 910 SMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQ 969
++ + E Q P P+R + W +PP ++
Sbjct: 569 ------EALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLR--QEEDIPPKVPQR 620
Query: 970 PSLLAP-------PGPPNWLGPPTQSGTPRGGALLLLRNSP---QPLRRAASGGSGSEN 1018
+ ++P PG + LGP S R L R P PL+R +SG S S +
Sbjct: 621 TTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSS 679
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 19/167 (11%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL 631
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 44.3 bits (103), Expect = 6e-04
Identities = 51/222 (22%), Positives = 91/222 (40%), Gaps = 38/222 (17%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEE---AGLLRRQRQYFELQCRQYKRKMLLA 653
+ + +RE+ +++ + Q EEE +L++Q + + +YKRK
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK---- 478
Query: 654 RHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQL 695
L++ E L ++ Q+ L Q + R +E + L
Sbjct: 479 --QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/198 (24%), Positives = 91/198 (45%), Gaps = 12/198 (6%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKE-QLQQCQAEEEAGLLRRQRQYFELQCRQ 645
Y +E+ +E PS+ E LR+ +LQ E L R+Q + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAEL 705
+KR++L R ++ +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEE-QKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEER 437
Query: 706 TRLQHQTE-LGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQ 764
R +H+ E + QLE +R+ + L+Q+ + +Q L+ K Q+++Q Q ++Q RQ
Sbjct: 438 RRAEHEQEYIRRQLEEEQRQLEILQQQ---LLHEQALLLEYKRKQLEEQRQAE-RLQ-RQ 492
Query: 765 YKALRAHLLETTPKAQHK 782
K R +L+ + Q +
Sbjct: 493 LKQERDYLVSLQHQRQEQ 510
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 228 bits (580), Expect = 3e-59
Identities = 130/284 (45%), Positives = 178/284 (62%), Gaps = 14/284 (4%)
Query: 21 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 80
K DPE+LF+ L +IG GSFG V+ D R +VVAIK + +++ ++ +DI +E+ L
Sbjct: 17 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 74
Query: 81 QKLRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGL 139
+ P +Y G YL++ W++MEY G SA DLLE PL E +IA + L+GL
Sbjct: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 132
Query: 140 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVIL 195
YLHS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 191
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFR 255
+ YD K D+WSLGIT IELA +PP ++ M L+ I +N P L+ G++S+ +
Sbjct: 192 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GNYSKPLK 248
Query: 256 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPT-VIMDLIQRTK 298
FV++CL K P RPT++ LLKH+F+LR T + +LI R K
Sbjct: 249 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 292
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 228 bits (580), Expect = 3e-59
Identities = 130/284 (45%), Positives = 178/284 (62%), Gaps = 14/284 (4%)
Query: 21 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 80
K DPE+LF+ L +IG GSFG V+ D R +VVAIK + +++ ++ +DI +E+ L
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 86
Query: 81 QKLRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGL 139
+ P +Y G YL++ W++MEY G SA DLLE PL E +IA + L+GL
Sbjct: 87 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 144
Query: 140 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVIL 195
YLHS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 203
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFR 255
+ YD K D+WSLGIT IELA +PP ++ M L+ I +N P L+ G++S+ +
Sbjct: 204 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GNYSKPLK 260
Query: 256 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPT-VIMDLIQRTK 298
FV++CL K P RPT++ LLKH+F+LR T + +LI R K
Sbjct: 261 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 304
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 227 bits (578), Expect = 5e-59
Identities = 191/609 (31%), Positives = 294/609 (48%), Gaps = 116/609 (19%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKE 553
+ + Q+Q L+ +L+ ER ++ LQ + + QR EK H G EK
Sbjct: 478 KQLEEQRQAERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKP 531
Query: 554 ARAAQAEER 562
A A + EER
Sbjct: 532 AWAKEVEER 540
Score = 55.8 bits (133), Expect = 2e-07
Identities = 41/160 (25%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ E + ++R EE+ R+L IL +Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLL 466
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQ 844
+ +L + +L+E ++AE L++QL+QE + L + Q
Sbjct: 467 HEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYLVSLQ 504
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 19/167 (11%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL 631
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 45.1 bits (105), Expect = 4e-04
Identities = 57/277 (20%), Positives = 109/277 (39%), Gaps = 38/277 (13%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEE---AGLLRRQRQYFELQCRQYKRKMLLA 653
+ + +RE+ +++ + Q EEE +L++Q + + +YKRK
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK---- 478
Query: 654 RHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTE 713
L++ E L ++ Q+ L Q + R +E + L + + + E
Sbjct: 479 --QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 714 LGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQI 750
+ + N++ + K A ++ +S+ I
Sbjct: 537 VEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSI 573
Score = 44.7 bits (104), Expect = 5e-04
Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 34/300 (11%)
Query: 763 RQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQ 822
R + L+ E + + + L ++ +E + K +LAE+ Q E Q RL+E Q
Sbjct: 352 RDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER--QKRIEEQKEQRRRLEEQQ 409
Query: 823 EAEFQALRQQLQQELELLNAYQSKIKIRTESQHEREL--RELEQRVALRRALLEQRVEEE 880
E + +QQ +++ + + R ++HE+E R+LE+ L +Q + E+
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 881 LLALQTGR----SERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPP 936
L L+ R +R L+RQ ++ + + P +G +P
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGM-SPS 528
Query: 937 PAPAWPSRPVPRSGAHWSHGP----------PPPGMPP-----------PAWRQPSLLAP 975
PAW RS + P P +PP PA R P +L P
Sbjct: 529 EKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPA-RTPPMLRP 587
Query: 976 PGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVGPPAAAVPGPLSRSTS 1035
P P + +G AL ++ + + SG + NV +P S TS
Sbjct: 588 VDPQI---PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTS 644
Score = 42.0 bits (97), Expect = 0.003
Identities = 59/253 (23%), Positives = 96/253 (37%), Gaps = 33/253 (13%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E R E +L Q +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLH 467
Query: 552 KEA-----RAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPK 606
++A + Q EE++ + + Q K+E L+ Q + + R + K
Sbjct: 468 EQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSP 527
Query: 607 REKAEWLLRQKEQ 619
EK W +E+
Sbjct: 528 SEKPAWAKEVEER 540
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/198 (24%), Positives = 91/198 (45%), Gaps = 12/198 (6%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKE-QLQQCQAEEEAGLLRRQRQYFELQCRQ 645
Y +E+ +E PS+ E LR+ +LQ E L R+Q + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAEL 705
+KR++L R ++ +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEE-QKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEER 437
Query: 706 TRLQHQTE-LGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQ 764
R +H+ E + QLE +R+ + L+Q+ + +Q L+ K Q+++Q Q ++Q RQ
Sbjct: 438 RRAEHEQEYIRRQLEEEQRQLEILQQQ---LLHEQALLLEYKRKQLEEQRQAE-RLQ-RQ 492
Query: 765 YKALRAHLLETTPKAQHK 782
K R +L+ + Q +
Sbjct: 493 LKQERDYLVSLQHQRQEQ 510
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 227 bits (578), Expect = 5e-59
Identities = 191/609 (31%), Positives = 294/609 (48%), Gaps = 116/609 (19%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKE 553
+ + Q+Q L+ +L+ ER ++ LQ + + QR EK H G EK
Sbjct: 478 KQLEEQRQAERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKP 531
Query: 554 ARAAQAEER 562
A A + EER
Sbjct: 532 AWAKEVEER 540
Score = 55.8 bits (133), Expect = 2e-07
Identities = 41/160 (25%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ E + ++R EE+ R+L IL +Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLL 466
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQ 844
+ +L + +L+E ++AE L++QL+QE + L + Q
Sbjct: 467 HEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYLVSLQ 504
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 19/167 (11%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL 631
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 45.1 bits (105), Expect = 4e-04
Identities = 57/277 (20%), Positives = 109/277 (39%), Gaps = 38/277 (13%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEE---AGLLRRQRQYFELQCRQYKRKMLLA 653
+ + +RE+ +++ + Q EEE +L++Q + + +YKRK
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK---- 478
Query: 654 RHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTE 713
L++ E L ++ Q+ L Q + R +E + L + + + E
Sbjct: 479 --QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 714 LGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQI 750
+ + N++ + K A ++ +S+ I
Sbjct: 537 VEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSI 573
Score = 44.7 bits (104), Expect = 5e-04
Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 34/300 (11%)
Query: 763 RQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQ 822
R + L+ E + + + L ++ +E + K +LAE+ Q E Q RL+E Q
Sbjct: 352 RDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER--QKRIEEQKEQRRRLEEQQ 409
Query: 823 EAEFQALRQQLQQELELLNAYQSKIKIRTESQHEREL--RELEQRVALRRALLEQRVEEE 880
E + +QQ +++ + + R ++HE+E R+LE+ L +Q + E+
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 881 LLALQTGR----SERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPP 936
L L+ R +R L+RQ ++ + + P +G +P
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGM-SPS 528
Query: 937 PAPAWPSRPVPRSGAHWSHGP----------PPPGMPP-----------PAWRQPSLLAP 975
PAW RS + P P +PP PA R P +L P
Sbjct: 529 EKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPA-RTPPMLRP 587
Query: 976 PGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVGPPAAAVPGPLSRSTS 1035
P P + +G AL ++ + + SG + NV +P S TS
Sbjct: 588 VDPQI---PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTS 644
Score = 42.0 bits (97), Expect = 0.003
Identities = 59/253 (23%), Positives = 96/253 (37%), Gaps = 33/253 (13%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E R E +L Q +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLH 467
Query: 552 KEA-----RAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPK 606
++A + Q EE++ + + Q K+E L+ Q + + R + K
Sbjct: 468 EQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSP 527
Query: 607 REKAEWLLRQKEQ 619
EK W +E+
Sbjct: 528 SEKPAWAKEVEER 540
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/198 (24%), Positives = 91/198 (45%), Gaps = 12/198 (6%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKE-QLQQCQAEEEAGLLRRQRQYFELQCRQ 645
Y +E+ +E PS+ E LR+ +LQ E L R+Q + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAEL 705
+KR++L R ++ +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEE-QKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEER 437
Query: 706 TRLQHQTE-LGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQ 764
R +H+ E + QLE +R+ + L+Q+ + +Q L+ K Q+++Q Q ++Q RQ
Sbjct: 438 RRAEHEQEYIRRQLEEEQRQLEILQQQ---LLHEQALLLEYKRKQLEEQRQAE-RLQ-RQ 492
Query: 765 YKALRAHLLETTPKAQHK 782
K R +L+ + Q +
Sbjct: 493 LKQERDYLVSLQHQRQEQ 510
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 227 bits (578), Expect = 5e-59
Identities = 134/391 (34%), Positives = 212/391 (54%), Gaps = 31/391 (7%)
Query: 24 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 83
PE++F L ++G GS+G+V+ A + +VVAIK++ Q+IIKE+ +Q+
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-----QEIIKEISIMQQC 77
Query: 84 RHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
P ++Y G Y + W+VMEYC GS SD++ + K L E EIA + L+GL YL
Sbjct: 78 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYL 137
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMD 198
H IHRD+KAGNILL+ G KL DFG A MA N+ +GTP+WMAPEVI
Sbjct: 138 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---Q 194
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGH-WSEYFRNF 257
E Y+ D+WSLGIT IE+AE KPP +++ M A++ I N P + WS+ F +F
Sbjct: 195 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDF 254
Query: 258 VDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILF 317
V CL K P+ R T+ LL+H F+ +P +++ DLI + + Q R++++
Sbjct: 255 VKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEE--- 311
Query: 318 QEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADAS-- 375
E +E+E + + ++ S+ + + +MS A + +++ ++
Sbjct: 312 --------EEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLG 363
Query: 376 ----DNEEEEEEEEEEEEEEEGPEAREMAMM 402
++E+EEEE+ + P+ + + M
Sbjct: 364 TMVINSEDEEEEDGTMKRNATSPQVQRPSFM 394
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 225 bits (573), Expect = 2e-58
Identities = 139/389 (35%), Positives = 206/389 (52%), Gaps = 34/389 (8%)
Query: 24 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 83
PE++F L ++G GS+G+VY A ++VAIK++ Q+IIKE+ +Q+
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDL-----QEIIKEISIMQQC 80
Query: 84 RHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
P+ ++Y G Y + W+VMEYC GS SD++ + K L E EIA + L+GL YL
Sbjct: 81 DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYL 140
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMD 198
H IHRD+KAGNILL+ G KL DFG A MA N+ +GTP+WMAPEVI
Sbjct: 141 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---Q 197
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGH-WSEYFRNF 257
E Y+ D+WSLGIT IE+AE KPP +++ M A++ I N P + WS+ F +F
Sbjct: 198 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDF 257
Query: 258 VDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILF 317
V CL K P+ R T+ LL+H FV + +++ DLI D + Q R++ +
Sbjct: 258 VKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQ--- 314
Query: 318 QEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDN 377
++EE +E +GT+ + ++ + AS+ + N++ + D
Sbjct: 315 ------------DDEENSEEDEMDSGTMVRAVGD-EMGTVRV-ASTMTDGANTMIEHDDT 360
Query: 378 EEEEEEE---EEEEEEEEGPEAREMAMMQ 403
+ E+EEEEG R MQ
Sbjct: 361 LPSQLGTMVINAEDEEEEGTMKRRDETMQ 389
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 222 bits (566), Expect = 1e-57
Identities = 197/669 (29%), Positives = 308/669 (46%), Gaps = 134/669 (20%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAIGEKEARAA 557
L+ +L+ ER+ +H + QR +E + E + + + I A +
Sbjct: 457 AERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKS 516
Query: 558 QAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR----EKAE 611
Q Q + Q K L+ EA T Q + ENP P R +++
Sbjct: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
Query: 612 WLLRQKEQL 620
W LRQ+E +
Sbjct: 577 W-LRQEEDI 584
Score = 45.4 bits (106), Expect = 3e-04
Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 50/344 (14%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ + E +A+H+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
Q ++S Q R Q Q+ +E Y K + + S+ +E+
Sbjct: 466 QERDYLVSLQHQR--------------QEQRPVEKKPLYHYK-EGMSPSEKPAWAKEIPH 510
Query: 865 RVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIP 924
VA++ L A Q+ + + L Q EA + S R+
Sbjct: 511 LVAVKSQ------GPALTASQSVHEQPTKGLSGFQ----EALNVTSHRV----------- 549
Query: 925 AEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQPSLLAP-------PG 977
E Q P P+R + W +PP ++ + ++P PG
Sbjct: 550 -EMPRQNSDPTSENPPLPTRIEKFDRSSWLR--QEEDIPPKVPQRTTSISPALARKNSPG 606
Query: 978 PPNWLGPPTQSGTPRGGALLLLRNSP---QPLRRAASGGSGSEN 1018
+ LGP S R L R P PL+R +SG S S +
Sbjct: 607 NGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSS 650
Score = 41.6 bits (96), Expect = 0.004
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
+ + +RE+ +++ ++ Q EE+ R QRQ
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
Score = 37.0 bits (84), Expect = 0.097
Identities = 40/181 (22%), Positives = 86/181 (47%), Gaps = 20/181 (11%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQR-QYFELQCRQ 645
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTR--- 702
+KR++L R ++ +K+ ++ LE + RE ELR+ Q ++ R
Sbjct: 383 HKRQLLAERQKRIEE-------QKEQRRRLE-------EQQRREKELRKQQEREQRRHYE 428
Query: 703 AELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQT 762
++ R + + ++ EY +++ +E RQ A ++++Q K + + ++ Q QE ++
Sbjct: 429 EQMRREEERRRAEHEQEYKRKQLEEQRQ--AERLQRQLKQERDYLVSLQHQRQEQRPVEK 486
Query: 763 R 763
+
Sbjct: 487 K 487
Score = 35.8 bits (81), Expect = 0.22
Identities = 58/246 (23%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
++ H Q A EQL + +R Q ++ + ++ + +R + + E E + +G E
Sbjct: 271 VKNHSQRPAT-EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEE 329
Query: 539 AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL 598
E+ GE + E ++ L Q L ++R+ LR++QL+++
Sbjct: 330 EEE-----NDSGEPSSILNLPGESTLRRDFLRLQ-------LANKERSEALRRQQLEQQQ 377
Query: 599 QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL----LRRQ------RQYFELQCRQYKR 648
+EN ++ AE R +EQ +Q + EE LR+Q R Y E R+ +R
Sbjct: 378 RENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Query: 649 KMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRE-LELRQLQAVQRTRAELTR 707
+ A H ++ +KQ ++ + L RQ + R+ L Q Q ++ E
Sbjct: 438 RR--AEH-------EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKP 488
Query: 708 LQHQTE 713
L H E
Sbjct: 489 LYHYKE 494
Score = 33.5 bits (75), Expect = 1.1
Identities = 49/193 (25%), Positives = 83/193 (43%), Gaps = 13/193 (6%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR----QYKALRAHLLET 775
+++R E KH +R QP + +Q+K T K + +Y+ + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQY-DQSISEMLSSQALRLDETQEAEFQALRQQLQ 834
+ S + L E T + L Q ++ SE L Q L E Q+ E + ++QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 835 QELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSERI 892
E + Q + + R E Q E+ELR+ ++R R + R EEE + + +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 893 RSLLE-RQAREIE 904
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 222 bits (566), Expect = 1e-57
Identities = 197/669 (29%), Positives = 308/669 (46%), Gaps = 134/669 (20%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAIGEKEARAA 557
L+ +L+ ER+ +H + QR +E + E + + + I A +
Sbjct: 457 AERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKS 516
Query: 558 QAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR----EKAE 611
Q Q + Q K L+ EA T Q + ENP P R +++
Sbjct: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
Query: 612 WLLRQKEQL 620
W LRQ+E +
Sbjct: 577 W-LRQEEDI 584
Score = 45.4 bits (106), Expect = 3e-04
Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 50/344 (14%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ + E +A+H+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
Q ++S Q R Q Q+ +E Y K + + S+ +E+
Sbjct: 466 QERDYLVSLQHQR--------------QEQRPVEKKPLYHYK-EGMSPSEKPAWAKEIPH 510
Query: 865 RVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIP 924
VA++ L A Q+ + + L Q EA + S R+
Sbjct: 511 LVAVKSQ------GPALTASQSVHEQPTKGLSGFQ----EALNVTSHRV----------- 549
Query: 925 AEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQPSLLAP-------PG 977
E Q P P+R + W +PP ++ + ++P PG
Sbjct: 550 -EMPRQNSDPTSENPPLPTRIEKFDRSSWLR--QEEDIPPKVPQRTTSISPALARKNSPG 606
Query: 978 PPNWLGPPTQSGTPRGGALLLLRNSP---QPLRRAASGGSGSEN 1018
+ LGP S R L R P PL+R +SG S S +
Sbjct: 607 NGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSS 650
Score = 41.6 bits (96), Expect = 0.004
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
+ + +RE+ +++ ++ Q EE+ R QRQ
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
Score = 37.0 bits (84), Expect = 0.097
Identities = 40/181 (22%), Positives = 86/181 (47%), Gaps = 20/181 (11%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQR-QYFELQCRQ 645
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTR--- 702
+KR++L R ++ +K+ ++ LE + RE ELR+ Q ++ R
Sbjct: 383 HKRQLLAERQKRIEE-------QKEQRRRLE-------EQQRREKELRKQQEREQRRHYE 428
Query: 703 AELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQT 762
++ R + + ++ EY +++ +E RQ A ++++Q K + + ++ Q QE ++
Sbjct: 429 EQMRREEERRRAEHEQEYKRKQLEEQRQ--AERLQRQLKQERDYLVSLQHQRQEQRPVEK 486
Query: 763 R 763
+
Sbjct: 487 K 487
Score = 35.8 bits (81), Expect = 0.22
Identities = 58/246 (23%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
++ H Q A EQL + +R Q ++ + ++ + +R + + E E + +G E
Sbjct: 271 VKNHSQRPAT-EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEE 329
Query: 539 AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL 598
E+ GE + E ++ L Q L ++R+ LR++QL+++
Sbjct: 330 EEE-----NDSGEPSSILNLPGESTLRRDFLRLQ-------LANKERSEALRRQQLEQQQ 377
Query: 599 QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL----LRRQ------RQYFELQCRQYKR 648
+EN ++ AE R +EQ +Q + EE LR+Q R Y E R+ +R
Sbjct: 378 RENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Query: 649 KMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRE-LELRQLQAVQRTRAELTR 707
+ A H ++ +KQ ++ + L RQ + R+ L Q Q ++ E
Sbjct: 438 RR--AEH-------EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKP 488
Query: 708 LQHQTE 713
L H E
Sbjct: 489 LYHYKE 494
Score = 33.5 bits (75), Expect = 1.1
Identities = 49/193 (25%), Positives = 83/193 (43%), Gaps = 13/193 (6%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR----QYKALRAHLLET 775
+++R E KH +R QP + +Q+K T K + +Y+ + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQY-DQSISEMLSSQALRLDETQEAEFQALRQQLQ 834
+ S + L E T + L Q ++ SE L Q L E Q+ E + ++QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 835 QELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSERI 892
E + Q + + R E Q E+ELR+ ++R R + R EEE + + +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 893 RSLLE-RQAREIE 904
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 221 bits (564), Expect = 2e-57
Identities = 186/601 (30%), Positives = 285/601 (47%), Gaps = 129/601 (21%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKEARAAQAEE 561
L+ +L+ ER ++ LQ + + QR EK H G EK A A + EE
Sbjct: 457 AERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKPAWAKEVEE 510
Query: 562 R 562
R
Sbjct: 511 R 511
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E + Q EE++ + + Q K+E L+ Q +
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQ 477
Query: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQ 619
+ R + K EK W +E+
Sbjct: 478 RQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
Score = 43.9 bits (102), Expect = 8e-04
Identities = 33/136 (24%), Positives = 66/136 (48%), Gaps = 1/136 (0%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ + E +A+H+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 805 QSISEMLSSQALRLDE 820
Q ++S Q R ++
Sbjct: 466 QERDYLVSLQHQRQEQ 481
Score = 41.6 bits (96), Expect = 0.004
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
+ + +RE+ +++ ++ Q EE+ R QRQ
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Score = 40.0 bits (92), Expect = 0.012
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 763 RQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQ 822
R + L+ E + + + L ++ +E + K +LAE+ Q E Q RL+E Q
Sbjct: 352 RDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER--QKRIEEQKEQRRRLEEQQ 409
Query: 823 EAEFQALRQQLQQELELLNAYQSKIKIRTESQHERE-----LRELEQRVALRRALLEQRV 877
E + +QQ +++ + + R ++HE+E L E Q L+R L ++R
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER- 468
Query: 878 EEELLALQTGRSER 891
+ L++LQ R E+
Sbjct: 469 -DYLVSLQHQRQEQ 481
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
Score = 37.4 bits (85), Expect = 0.075
Identities = 57/284 (20%), Positives = 126/284 (44%), Gaps = 24/284 (8%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQR-QYFELQCRQ 645
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTR--- 702
+KR++L R ++ +K+ ++ LE + RE ELR+ Q ++ R
Sbjct: 383 HKRQLLAERQKRIEE-------QKEQRRRLE-------EQQRREKELRKQQEREQRRHYE 428
Query: 703 AELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQT 762
++ R + + ++ EY +++ +E RQ A ++++Q K + + ++ Q QE ++
Sbjct: 429 EQMRREEERRRAEHEQEYKRKQLEEQRQ--AERLQRQLKQERDYLVSLQHQRQEQRPVEK 486
Query: 763 RQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEML--SSQALRLDE 820
+ + + + A K + +R + + A+ + ++ L S++ +
Sbjct: 487 KPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISG 546
Query: 821 TQEAEFQALRQQLQQELELLNAYQSKIKIRTESQ--HERELREL 862
Q A + + + ++ L A +S+ T SQ HE+ + L
Sbjct: 547 VQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGL 590
Score = 35.8 bits (81), Expect = 0.22
Identities = 58/246 (23%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
++ H Q A EQL + +R Q ++ + ++ + +R + + E E + +G E
Sbjct: 271 VKNHSQRPAT-EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEE 329
Query: 539 AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL 598
E+ GE + E ++ L Q L ++R+ LR++QL+++
Sbjct: 330 EEE-----NDSGEPSSILNLPGESTLRRDFLRLQ-------LANKERSEALRRQQLEQQQ 377
Query: 599 QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL----LRRQ------RQYFELQCRQYKR 648
+EN ++ AE R +EQ +Q + EE LR+Q R Y E R+ +R
Sbjct: 378 RENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Query: 649 KMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRE-LELRQLQAVQRTRAELTR 707
+ A H ++ +KQ ++ + L RQ + R+ L Q Q ++ E
Sbjct: 438 RR--AEH-------EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKP 488
Query: 708 LQHQTE 713
L H E
Sbjct: 489 LYHYKE 494
Score = 34.3 bits (77), Expect = 0.63
Identities = 54/241 (22%), Positives = 94/241 (39%), Gaps = 36/241 (14%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E +R + + + Q E
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQE 467
Query: 552 KEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLR-----KEQLKEELQENPSTPK 606
++ + +R+ Q+ + +KK L E + K +E+ + Q +P+ P
Sbjct: 468 RDYLVSLQHQRQEQRPV---EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPH 524
Query: 607 R 607
+
Sbjct: 525 K 525
Score = 33.5 bits (75), Expect = 1.1
Identities = 49/193 (25%), Positives = 83/193 (43%), Gaps = 13/193 (6%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR----QYKALRAHLLET 775
+++R E KH +R QP + +Q+K T K + +Y+ + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQY-DQSISEMLSSQALRLDETQEAEFQALRQQLQ 834
+ S + L E T + L Q ++ SE L Q L E Q+ E + ++QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 835 QELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSERI 892
E + Q + + R E Q E+ELR+ ++R R + R EEE + + +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 893 RSLLE-RQAREIE 904
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 221 bits (564), Expect = 2e-57
Identities = 186/601 (30%), Positives = 285/601 (47%), Gaps = 129/601 (21%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKEARAAQAEE 561
L+ +L+ ER ++ LQ + + QR EK H G EK A A + EE
Sbjct: 457 AERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKPAWAKEVEE 510
Query: 562 R 562
R
Sbjct: 511 R 511
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E + Q EE++ + + Q K+E L+ Q +
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQ 477
Query: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQ 619
+ R + K EK W +E+
Sbjct: 478 RQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
Score = 43.9 bits (102), Expect = 8e-04
Identities = 33/136 (24%), Positives = 66/136 (48%), Gaps = 1/136 (0%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T + +LQ + R+E R Q + + E +KR+ RQK + ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
++ + K+ ++ + Q R Y+ + E +A+H+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 805 QSISEMLSSQALRLDE 820
Q ++S Q R ++
Sbjct: 466 QERDYLVSLQHQRQEQ 481
Score = 41.6 bits (96), Expect = 0.004
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
+ + +RE+ +++ ++ Q EE+ R QRQ
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Score = 40.0 bits (92), Expect = 0.012
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 763 RQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQ 822
R + L+ E + + + L ++ +E + K +LAE+ Q E Q RL+E Q
Sbjct: 352 RDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER--QKRIEEQKEQRRRLEEQQ 409
Query: 823 EAEFQALRQQLQQELELLNAYQSKIKIRTESQHERE-----LRELEQRVALRRALLEQRV 877
E + +QQ +++ + + R ++HE+E L E Q L+R L ++R
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER- 468
Query: 878 EEELLALQTGRSER 891
+ L++LQ R E+
Sbjct: 469 -DYLVSLQHQRQEQ 481
Score = 37.4 bits (85), Expect = 0.075
Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 24/196 (12%)
Query: 737 RQQPKSLKSKELQIKKQ-FQETCKIQTRQYKALRAHLL----------ETTPKAQHKSLL 785
R LKSK+ K Q F E+C ++ + L+ E + Q K +
Sbjct: 247 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI 306
Query: 786 KRLKEEQTRK-------LAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELE 838
R K+++ K E+ + E S L + T +F L+ ++ E
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 839 LLNAYQSKIKIRTESQHEREL-----RELEQRVALRRALLEQRVEEELLALQTGRSERIR 893
L Q + + R +H+R+L + +E++ RR L EQ+ E+ L Q R +R R
Sbjct: 367 ALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-R 425
Query: 894 SLLERQAREIEAFDAE 909
E+ RE E AE
Sbjct: 426 HYEEQMRREEERRRAE 441
Score = 37.4 bits (85), Expect = 0.075
Identities = 57/284 (20%), Positives = 126/284 (44%), Gaps = 24/284 (8%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQR-QYFELQCRQ 645
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 646 YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTR--- 702
+KR++L R ++ +K+ ++ LE + RE ELR+ Q ++ R
Sbjct: 383 HKRQLLAERQKRIEE-------QKEQRRRLE-------EQQRREKELRKQQEREQRRHYE 428
Query: 703 AELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQT 762
++ R + + ++ EY +++ +E RQ A ++++Q K + + ++ Q QE ++
Sbjct: 429 EQMRREEERRRAEHEQEYKRKQLEEQRQ--AERLQRQLKQERDYLVSLQHQRQEQRPVEK 486
Query: 763 RQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEML--SSQALRLDE 820
+ + + + A K + +R + + A+ + ++ L S++ +
Sbjct: 487 KPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISG 546
Query: 821 TQEAEFQALRQQLQQELELLNAYQSKIKIRTESQ--HERELREL 862
Q A + + + ++ L A +S+ T SQ HE+ + L
Sbjct: 547 VQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGL 590
Score = 35.8 bits (81), Expect = 0.22
Identities = 58/246 (23%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
++ H Q A EQL + +R Q ++ + ++ + +R + + E E + +G E
Sbjct: 271 VKNHSQRPAT-EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEE 329
Query: 539 AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL 598
E+ GE + E ++ L Q L ++R+ LR++QL+++
Sbjct: 330 EEE-----NDSGEPSSILNLPGESTLRRDFLRLQ-------LANKERSEALRRQQLEQQQ 377
Query: 599 QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL----LRRQ------RQYFELQCRQYKR 648
+EN ++ AE R +EQ +Q + EE LR+Q R Y E R+ +R
Sbjct: 378 RENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Query: 649 KMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRE-LELRQLQAVQRTRAELTR 707
+ A H ++ +KQ ++ + L RQ + R+ L Q Q ++ E
Sbjct: 438 RR--AEH-------EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKP 488
Query: 708 LQHQTE 713
L H E
Sbjct: 489 LYHYKE 494
Score = 34.3 bits (77), Expect = 0.63
Identities = 54/241 (22%), Positives = 94/241 (39%), Gaps = 36/241 (14%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E +R + + + Q E
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQE 467
Query: 552 KEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLR-----KEQLKEELQENPSTPK 606
++ + +R+ Q+ + +KK L E + K +E+ + Q +P+ P
Sbjct: 468 RDYLVSLQHQRQEQRPV---EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPH 524
Query: 607 R 607
+
Sbjct: 525 K 525
Score = 33.5 bits (75), Expect = 1.1
Identities = 49/193 (25%), Positives = 83/193 (43%), Gaps = 13/193 (6%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR----QYKALRAHLLET 775
+++R E KH +R QP + +Q+K T K + +Y+ + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQY-DQSISEMLSSQALRLDETQEAEFQALRQQLQ 834
+ S + L E T + L Q ++ SE L Q L E Q+ E + ++QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 835 QELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSERI 892
E + Q + + R E Q E+ELR+ ++R R + R EEE + + +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 893 RSLLE-RQAREIE 904
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 221 bits (562), Expect = 4e-57
Identities = 128/282 (45%), Positives = 176/282 (62%), Gaps = 14/282 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DPE+LF+ L IG GSFG VY D EVVAIK + +++ ++ +DI +E+ L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 72
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGLAY 141
P +Y G YL+ W++MEY G SA DLL+ PL+E IA + L+GL Y
Sbjct: 73 CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK--PGPLEETYIATILREILKGLDY 130
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAM 197
LHS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 131 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 187
Query: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNF 257
+ YD K D+WSLGIT IELA+ +PP +++ M L+ I +N P L+ H S+ F+ F
Sbjct: 188 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH-SKPFKEF 246
Query: 258 VDSCLQKIPQDRPTSEVLLKHRFVLR-ERPPTVIMDLIQRTK 298
V++CL K P+ RPT++ LLKH+F+ R + + + +LI R K
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 218 bits (554), Expect = 3e-56
Identities = 123/281 (43%), Positives = 172/281 (61%), Gaps = 12/281 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DPE+LF+ L IG GSFG V+ D R +VVAIK + +++ ++ +DI +E+ L +
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 76
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
+Y G YL+ W++MEY LG S L + P E +IA + L+GL YL
Sbjct: 77 CDSSYVTKYYGSYLKGSKLWIIMEY-LGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMD 198
HS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---Q 192
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFV 258
+ YD K D+WSLGIT IELA+ +PP +M+ M L+ I +N P L G +++ F+ F+
Sbjct: 193 QSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL-VGDFTKSFKEFI 251
Query: 259 DSCLQKIPQDRPTSEVLLKHRFVLRERPPT-VIMDLIQRTK 298
D+CL K P RPT++ LLKH+F+++ T + +LI R K
Sbjct: 252 DACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFK 292
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 214 bits (544), Expect = 4e-55
Identities = 239/960 (24%), Positives = 408/960 (42%), Gaps = 115/960 (11%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
+PE + + E+G G+FG VY A++ S + A K + +S E+ +D + E+ L
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---TKSEEELEDYMVEIDILAS 85
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAY 141
HPN ++ + E+ W+++E+C G A D + + ++PL E +I V L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVIL-- 195
LH + +IHRD+KAGNIL + G +KL DFG + + +SF+GTPYWMAPEV++
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL-QSGHWSEYF 254
+ YD K DVWSLGIT IE+AE +PP +N M L IA++E P L Q WS F
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNF 265
Query: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKK 314
++F+ CL+K R T+ LL+H FV + I +LI K V E
Sbjct: 266 KDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP-IRELIAEAKAEVTE----------- 313
Query: 315 ILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADA 374
E +G + +EEEE E +L S + +SI ASS+ ++ A
Sbjct: 314 ----EVEDG---KEEDEEEETE------NSLPIPASKRASSDLSI-ASSEEDKLSQNACI 359
Query: 375 SDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSII--HRLPGSDNLYDDPYQP 432
++ E+ E E++ E E E V + I +L L+D
Sbjct: 360 LESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVI 419
Query: 433 EITPSPLQPPAAPAP-TSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQ 491
+ +P P T + + +++ I + + ++ E+ ++Q
Sbjct: 420 KENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQ 479
Query: 492 LSGYKRMRRQHQK----QLLALESRLRGERE------EHSARLQRELEAQRAGFGAEAEK 541
+ K ++ + K Q + L S+ GE+E + L +E ++ G + +K
Sbjct: 480 MFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQK 539
Query: 542 --LARRHQAIGEKEAR-AAQAEERKFQQHILGQQKKELAALLEAQKRTYKL--------R 590
++ IG EA AQ + + KE+ + QK K
Sbjct: 540 DVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEV--GQKLINKPMVGPEAGGT 597
Query: 591 KEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKM 650
KE +E+ E + + E + E + EE G + + + +
Sbjct: 598 KEVPIKEIVEMNEIEEGKNKEQAINSSENIM--DINEEPGTTEGEEITESSSTEEMEVRS 655
Query: 651 LLARHSLDQDLLR---EDLNKKQTQKDLE----CALLLRQHEATRELELRQLQAV----- 698
++A DQ L +D +K TQ D E + ++ E T + + Q V
Sbjct: 656 VVA--DTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSI 713
Query: 699 ------QRTRAELTRL-QHQTELGNQLEYNKRREQELRQKHAAQVR------------QQ 739
+ E+ L + +T L + E K + + A +
Sbjct: 714 NINSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSK 773
Query: 740 PKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKS-----LLKRLKEEQTR 794
K S LQ ++ ++T K +TR++ + TT K S L+ L+ ++ R
Sbjct: 774 TKDSGSISLQETRRQKKTLK-KTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELR 832
Query: 795 KLAIL---AEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRT 851
+L L ++ Q ++ L Q ++ E E + ++Q QE+E L Q + R
Sbjct: 833 ELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERL 892
Query: 852 ESQHERELR--------ELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREI 903
E +H LR E E+ ++ + +L+ R +E + ++ E + L++R+ E+
Sbjct: 893 EQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEEL 952
Score = 98.2 bits (243), Expect = 4e-20
Identities = 91/432 (21%), Positives = 198/432 (45%), Gaps = 35/432 (8%)
Query: 468 TIRTASLVSRQIQEHEQDSALREQ-LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQR 526
++ T+ +V+ + E+ LR Q L + ++++ Q+ L S+L+ +RE+ R ++
Sbjct: 806 SVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQ 865
Query: 527 ELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRT 586
E+ +++ + E E L ++ + E+ + R + I G+Q+KEL+ +
Sbjct: 866 EMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELS-------KF 918
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
+ K + KE + E PK + E + R+KE+L Q Q +E +++Q+Q + ++
Sbjct: 919 QNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKI 978
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECAL--LLRQH-EATRELELRQLQAVQRTRA 703
++ +++++ L NK+Q + E A+ L +H + +L +QL+ +
Sbjct: 979 IQQQKAELANIERECLN---NKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQR 1035
Query: 704 ELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR 763
+H+ E YN+R +EL+ + + + PK +S+ F+++ +I +
Sbjct: 1036 HQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINS- 1094
Query: 764 QYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQE 823
TP + + +E+ R+ Q+ + ++M Q E
Sbjct: 1095 ----------TATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQL-----QCE 1139
Query: 824 AEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRV-----E 878
A + L Q ++ LL ++++ + +H +EL+E +++ R+ LE+ E
Sbjct: 1140 ANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQE 1199
Query: 879 EELLALQTGRSE 890
+E+ TG SE
Sbjct: 1200 QEVFFKMTGESE 1211
Score = 73.6 bits (179), Expect = 9e-13
Identities = 77/361 (21%), Positives = 174/361 (48%), Gaps = 24/361 (6%)
Query: 552 KEARAAQAEERKFQQHI---LGQQKKELAALLEAQKRTYKLRKEQLKEELQ-ENPSTPKR 607
+E R Q EE++ QQ + L QQ++++ E + + K + +Q E L+ + T +R
Sbjct: 832 RELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIER 891
Query: 608 EKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLN 667
+ E R +++ ++ + E+E L + F+ + K++++ ++L +E +
Sbjct: 892 LEQEHTNRLRDEAKRIKGEQEKELSK-----FQNMLKNRKKEVINEVEKAPKELRKELMK 946
Query: 668 KKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGN-QLEYNKRREQ 726
+++ + L QH +E +Q Q + + ++ + Q + EL N + E ++Q
Sbjct: 947 RRKEE------LAQSQHAQEQEFVQKQQQELDGSLKKIIQ-QQKAELANIERECLNNKQQ 999
Query: 727 ELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKS-LL 785
+R + AA + + L+ K +K+Q ++ +Q Q L+ H ET ++ L+
Sbjct: 1000 LMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQL--LKRHEKETEQMQRYNQRLI 1057
Query: 786 KRLKEEQTRKLAILAE-QYDQSISEM-LSSQALRLDETQEAEFQALRQQLQQELELLNAY 843
+ LK QT++ A L + Q ++ + M + ++LR++ T + R +++Q
Sbjct: 1058 EELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQD--RDKIKQFAAQEEKR 1115
Query: 844 QSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREI 903
Q ++ +HE ++R+L+ + L Q E+ L +++++ L E ++E+
Sbjct: 1116 QKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQEL 1175
Query: 904 E 904
+
Sbjct: 1176 K 1176
Score = 62.0 bits (149), Expect = 3e-09
Identities = 64/283 (22%), Positives = 127/283 (44%), Gaps = 32/283 (11%)
Query: 658 DQDLLREDLNKKQTQKDLECALLLRQHEATRE-----LELRQLQAVQRTRAELT--RLQH 710
D D E+L + Q+ E L ++ + ++ L+ ++ Q +R E+ + Q+
Sbjct: 815 DSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQY 874
Query: 711 QTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRA 770
E+ N + K+ + L Q+H ++R + K +K ++ + +FQ K + ++
Sbjct: 875 DQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEV----I 930
Query: 771 HLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQAL- 829
+ +E PK K L+KR KEE + +++ Q + L ++ + Q+AE +
Sbjct: 931 NEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIE 990
Query: 830 RQQLQQELELLNAYQSKIKIRTESQHERELREL------EQRVALRRALLE--------- 874
R+ L + +L+ A ++ I E +H +E +L +Q R LL+
Sbjct: 991 RECLNNKQQLMRAREAAIW-ELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQM 1049
Query: 875 ----QRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRL 913
QR+ EEL QT R+ + +A+ A +S+R+
Sbjct: 1050 QRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRI 1092
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 210 bits (535), Expect = 5e-54
Identities = 183/567 (32%), Positives = 272/567 (47%), Gaps = 94/567 (16%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 AKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA ++ L+GLA+LH H++IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP---- 286
M AL+ I +N P L+S WS+ F +F++ CL K RP++E LLKH F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQ 297
Query: 287 -PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTL 345
+ D I RT+ E D +Y +E E PE+E E ++ G
Sbjct: 298 VRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGES 350
Query: 346 T-----------SLESSHSVPSMSISASSQSSSVNS-----LADASDNEEEEEEEEEEEE 389
T + E S ++ + Q LA+ E+++E+ E
Sbjct: 351 TLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE 410
Query: 390 EEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTS 449
E++ E RE QE E RL + +
Sbjct: 411 EQQRRE-REARRQQEREQRRREQEE-KRRLEELERRRKE--------------------- 447
Query: 450 TTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQD-SALREQLSGYKRMRRQHQKQLLA 508
RRRA R R + RQ++E ++ L++QL Q+Q +
Sbjct: 448 --EEERRRAEEEKR---RVEREQEYIRRQLEEEQRHLEVLQQQLL---------QEQAML 493
Query: 509 LESRLRGEREEH--SARLQRELEAQRA 533
LE R R E EEH + RLQR+L+ ++A
Sbjct: 494 LECRWR-EMEEHRQAERLQRQLQQEQA 519
Score = 61.6 bits (148), Expect = 4e-09
Identities = 54/202 (26%), Positives = 105/202 (51%), Gaps = 14/202 (6%)
Query: 659 QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRT--RAELTRLQHQTELGN 716
+ LR D + Q Q++ E + LR+ + +E +LR+ + +R R++ Q E
Sbjct: 349 ESTLRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 717 QLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETT 776
+LE +RRE+E R RQQ + + +E + K++ +E + + + + RA +
Sbjct: 408 RLEEQQRREREAR-------RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 777 PKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQE 836
+ + + + ++L+EEQ R L +L +Q Q + +L + ++E ++AE L++QLQQE
Sbjct: 461 VEREQEYIRRQLEEEQ-RHLEVLQQQLLQEQAMLLECRWREMEEHRQAE--RLQRQLQQE 517
Query: 837 LELLNAYQSKIKIRTESQHERE 858
L + Q + R QH ++
Sbjct: 518 QAYLLSLQHDHR-RPHPQHSQQ 538
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/176 (29%), Positives = 88/176 (50%), Gaps = 17/176 (9%)
Query: 538 EAEKLARRHQAIGEKEARAAQAEERKF---QQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E + RR Q + E++ R + +R+ +Q + QQK++ L E Q+R + R++Q
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+E+ + KR E R+KE+ ++ +AEEE + R+++Y Q + +R +
Sbjct: 425 REQ-RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL---- 479
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQH 710
L Q LL+E LEC R+ E R+ E Q Q +Q+ +A L LQH
Sbjct: 480 EVLQQQLLQEQAML------LECR--WREMEEHRQAERLQRQ-LQQEQAYLLSLQH 526
Score = 50.4 bits (119), Expect = 9e-06
Identities = 85/361 (23%), Positives = 142/361 (39%), Gaps = 41/361 (11%)
Query: 693 RQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSK--ELQI 750
RQ++ + + TR + + + EY+ E+E + + +P S+ + E +
Sbjct: 296 RQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEE---EEVPEQEGEPSSIVNVPGESTL 352
Query: 751 KKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEM 810
++ F + + +ALR L ++L+E++ K +LAE+ Q E
Sbjct: 353 RRDFLRLQQENKERSEALRRQQLLQE---------QQLREQEEYKRQLLAER--QKRIEQ 401
Query: 811 LSSQALRLDETQEAEFQALRQ----QLQQELELLNAYQSKIKIRTESQHERELRELEQRV 866
Q RL+E Q E +A RQ Q ++E E + + R E + R E ++RV
Sbjct: 402 QKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461
Query: 867 ALRRALLEQRVEEE---LLALQTGRSERIRSLLERQAREIEAF-DAESMRLGFSS----- 917
+ + +++EEE L LQ + LLE + RE+E AE ++
Sbjct: 462 EREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYL 521
Query: 918 MALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQPSLLAPPG 977
++L Q PPP S+P H P P PA R +
Sbjct: 522 LSLQHDHRRPHPQHSQQPPPPQQERSKPS-------FHAPEPKAHYEPADRAREVEDRFR 574
Query: 978 PPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVGPPAAAVPGPLSRSTSVA 1037
N P QS + G +L P P R + SE+V P P + + +A
Sbjct: 575 KTNHSSPEAQS--KQTGRVL---EPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLA 629
Query: 1038 S 1038
S
Sbjct: 630 S 630
Score = 48.5 bits (114), Expect = 3e-05
Identities = 59/266 (22%), Positives = 117/266 (43%), Gaps = 18/266 (6%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
I++ + +R QL + R+ + + E G EE ++E E
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSI-VNVP 347
Query: 539 AEKLARRH----QAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E RR Q ++ + A + ++ +Q + Q++ + L E QKR + ++++
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+ E Q+ R + E R++EQ ++ + EE L R+R+ E + R + K + R
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEE----LERRRKEEEERRRAEEEKRRVER 463
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTEL 714
+Q+ +R L ++Q ++ LL++ E R+++ + +AE RLQ Q L
Sbjct: 464 ---EQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREME--EHRQAE--RLQRQ--L 514
Query: 715 GNQLEYNKRREQELRQKHAAQVRQQP 740
+ Y + + R+ H +Q P
Sbjct: 515 QQEQAYLLSLQHDHRRPHPQHSQQPP 540
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/181 (25%), Positives = 91/181 (50%), Gaps = 11/181 (6%)
Query: 467 ATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQ--HQKQLLALESRLRGEREEHSARL 524
+T+R L +Q + ++ R+QL +++R Q +++QLLA + +++E RL
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 525 Q----RELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERK---FQQHILGQQKKELA 577
+ RE EA+R + + + + E E R + EER+ ++ + ++++ +
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR 469
Query: 578 ALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
LE ++R ++ ++QL +E RE E RQ E+LQ+ +E+A LL Q
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEH--RQAERLQRQLQQEQAYLLSLQHD 527
Query: 638 Y 638
+
Sbjct: 528 H 528
Score = 40.8 bits (94), Expect = 0.007
Identities = 53/194 (27%), Positives = 81/194 (41%), Gaps = 14/194 (7%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR------QYKALRAHLL 773
Y +R E KH +R QP + +Q+K T K + +Y
Sbjct: 274 YMQRPSTEQLLKHPF-IRDQPNE-RQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE 331
Query: 774 ETTPKAQHKSLLKRLKEEQT-RKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQ 832
E + S + + E T R+ + +Q ++ SE L Q L L E Q E + ++Q
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQL-LQEQQLREQEEYKRQ 390
Query: 833 LQQELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSE 890
L E + Q + + R E Q ERE R ++R RR E+R EEL + E
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE 450
Query: 891 RIRSLLERQAREIE 904
R R+ E + R +E
Sbjct: 451 RRRA--EEEKRRVE 462
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 207 bits (527), Expect = 4e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 48.1 bits (113), Expect = 4e-05
Identities = 83/387 (21%), Positives = 146/387 (37%), Gaps = 56/387 (14%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T E +LQ ++ +E + Q Q L+ ++R+ E KH RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
+I++Q +E +++ +Q + L+ + + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 805 -QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKI------------KIRT 851
+ + E S+ L+ QE + QQ QQ+ +L Q ++ +
Sbjct: 453 RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMN 512
Query: 852 ESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERI----------RSLLERQAR 901
+ RE+E+R + + + + TG I S R
Sbjct: 513 PADKPAWAREVEERTRMNKQQNSPLAKSK--PGSTGPEPPIPQASPGPPGPLSQTPPMQR 570
Query: 902 EIEAFDAESMRL-GFSSMALGGIPAEAAAQ-GYPAPPPAPAWPSRPVPRSGAHWSHGPPP 959
+E + L + L PA PAP P+ + ++ S G P
Sbjct: 571 PVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEG-PG 629
Query: 960 PGMPPPAWRQPSLLAPPGPPNWLG----PPTQSGTPRGGALLLLRNSPQP-------LRR 1008
P PPAW +P APP P SG +R P+ L+R
Sbjct: 630 PSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQR 689
Query: 1009 AASGGSGSENVGPPAAAVPGPLSRSTS 1035
A G+ + GPPA PGP + S++
Sbjct: 690 RAERGT-PKPPGPPAQP-PGPPNASSN 714
Score = 43.5 bits (101), Expect = 0.001
Identities = 56/229 (24%), Positives = 98/229 (42%), Gaps = 41/229 (17%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR+ E R+ E Q
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALRREEERRQAEREQ--------------------- 449
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQ 764
EY +++ +E RQ Q + Q + K LQ ++Q Q+ K Q +Q
Sbjct: 450 ---EYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Score = 43.1 bits (100), Expect = 0.001
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 33/203 (16%)
Query: 737 RQQPKSLKSKELQIKK-QFQETCKIQTR----------QYKALRAHLLETTPKAQHK--- 782
R P LKSK+ K F +TC I+T ++ +R E + Q K
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 783 --SLLKRLKEEQTRKLAILAEQYDQSISE--------------MLSSQALRLDETQEAEF 826
S KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 827 QALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQT 886
+AL+QQ Q + + ++ IK H+R+ R EQ+ RR +QR E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 887 GRSERIRSLLERQAREIEAFDAE 909
+R ++ RE E AE
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
Score = 38.9 bits (89), Expect = 0.026
Identities = 44/167 (26%), Positives = 84/167 (50%), Gaps = 22/167 (13%)
Query: 510 ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHIL 569
ES LR E RLQ+E ++ + ++ Q + +++ R +A + H+L
Sbjct: 348 ESTLRRE----FLRLQQENKSN--------SEALKQQQQLQQQQQRDPEAHIK----HLL 391
Query: 570 GQQKKELAALLEAQKRTYKL-RKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEE 628
Q+++ + E ++R + R+E+ + +LQE + E + LR++E+ +Q + E+E
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQ-ALRREEERRQAEREQE 450
Query: 629 --AGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQK 673
L QRQ LQ RQ +++ + SL Q ++ L K+Q Q+
Sbjct: 451 YKRKQLEEQRQSERLQ-RQLQQEHAYLK-SLQQQQQQQQLQKQQQQQ 495
Score = 33.5 bits (75), Expect = 1.1
Identities = 34/153 (22%), Positives = 75/153 (49%), Gaps = 10/153 (6%)
Query: 503 QKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEK--EARAAQAE 560
+++ L L+ + E + Q + + QR L +R + I E+ E R + +
Sbjct: 352 RREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQ 411
Query: 561 ERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQL 620
+R+ ++ Q+K++ L + Q LR+E+ + + + +++ E RQ E+L
Sbjct: 412 QRREREQRKLQEKEQQRRLEDMQA----LRREEERRQAEREQEYKRKQLEEQ--RQSERL 465
Query: 621 QQCQAEEEAGLLRR-QRQYFELQCRQYKRKMLL 652
Q+ Q ++E L+ Q+Q + Q ++ +++ LL
Sbjct: 466 QR-QLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 207 bits (527), Expect = 4e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 49.7 bits (117), Expect = 1e-05
Identities = 113/490 (23%), Positives = 188/490 (38%), Gaps = 86/490 (17%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR RE E RQ + Q + + Q Q+E
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALR-----REEERRQAEREQEYKRKQLEEQRQSE-- 463
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLET 775
R +++L+Q+HA KSL+ ++ Q + Q Q+ ++ K L +
Sbjct: 464 -------RLQRQLQQEHA-----YLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQ 835
P K R EE+TR + +Q + +++ +A
Sbjct: 512 NP--ADKPAWAREVEERTR----MNKQQNSPLAKSKPGSTGPEPPIPQA----------- 554
Query: 836 ELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSL 895
S SQ R +E + ++L+ RV + A RS+ SL
Sbjct: 555 ---------SPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ---SL 602
Query: 896 LERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSH 955
++ R + AF A + PAP P+ + ++ S
Sbjct: 603 QDQPTRNLAAFPA----------------SHDPDPAIPAPTATPSARGAVIRQNSDPTSE 646
Query: 956 GPPPPGMPPPAWRQPSLLAPPGPPNWLG----PPTQSGTPRGGALLLLRNSPQPLRRAAS 1011
G P P PPAW +P APP P SG +R S LRR+
Sbjct: 647 G-PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDP 705
Query: 1012 GGSGSENVGP 1021
G S++V P
Sbjct: 706 GWERSDSVLP 715
Score = 47.4 bits (111), Expect = 7e-05
Identities = 83/376 (22%), Positives = 148/376 (39%), Gaps = 68/376 (18%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T E +LQ ++ +E + Q Q L+ ++R+ E KH RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
+I++Q +E +++ +Q + L+ + + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
+ +L+E +++E L++QLQQE L + Q + Q +++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE--RLQRQLQQEHAYLKSLQ-------QQQQQQQLQKQQQ 493
Query: 865 RVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIP 924
+ L + L G + + R+ E + + S P
Sbjct: 494 QQLL------PGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGP 547
Query: 925 AEAAAQGYPAPP-PAPAWP--SRPV-PRSGAHWS---HGPPPPGMPPPAWRQPSLLAPP- 976
Q P PP P P RPV P+ G H S H P P R SL P
Sbjct: 548 EPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPT 607
Query: 977 ----------GPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSEN----VGPP 1022
P + PT + + RG ++R + P + G S N V P
Sbjct: 608 RNLAAFPASHDPDPAIPAPTATPSARGA---VIRQNSDP---TSEGPGPSPNPPAWVRPD 661
Query: 1023 AAAVPGPLSRSTSVAS 1038
A P R++S+A+
Sbjct: 662 NEAPPKVPQRTSSIAT 677
Score = 45.1 bits (105), Expect = 4e-04
Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 36/301 (11%)
Query: 510 ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHIL 569
ES LR E RLQ+E ++ + ++ Q + +++ R +A + H+L
Sbjct: 348 ESTLRRE----FLRLQQENKSN--------SEALKQQQQLQQQQQRDPEAHIK----HLL 391
Query: 570 GQQKKELAALLEAQKRTYKL-RKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEE 628
Q+++ + E ++R + R+E+ + +LQE R+ E +Q + EEE
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQ----------RRLEDMQALRREEE 441
Query: 629 AGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATR 688
R+++Y Q + ++ L R + + L ++Q Q+ L+ +Q +
Sbjct: 442 RRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ----KQQQQQLL 497
Query: 689 ELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSK-- 746
+ + L R + E+ + NK++ L + +P ++
Sbjct: 498 PGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG 557
Query: 747 ---ELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQY 803
L Q + Q +K+L AH + P A + L+++ TR LA +
Sbjct: 558 PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASH 617
Query: 804 D 804
D
Sbjct: 618 D 618
Score = 43.1 bits (100), Expect = 0.001
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 33/203 (16%)
Query: 737 RQQPKSLKSKELQIKK-QFQETCKIQTR----------QYKALRAHLLETTPKAQHK--- 782
R P LKSK+ K F +TC I+T ++ +R E + Q K
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 783 --SLLKRLKEEQTRKLAILAEQYDQSISE--------------MLSSQALRLDETQEAEF 826
S KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 827 QALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQT 886
+AL+QQ Q + + ++ IK H+R+ R EQ+ RR +QR E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 887 GRSERIRSLLERQAREIEAFDAE 909
+R ++ RE E AE
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 207 bits (527), Expect = 4e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 47.8 bits (112), Expect = 6e-05
Identities = 118/511 (23%), Positives = 197/511 (38%), Gaps = 95/511 (18%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR RE E RQ + Q + + Q Q+E
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALR-----REEERRQAEREQEYKRKQLEEQRQSE-- 463
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLET 775
R +++L+Q+HA KSL+ ++ Q + Q Q+ ++ K L +
Sbjct: 464 -------RLQRQLQQEHA-----YLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQ 835
P K R EE+TR + +Q + +++ +A
Sbjct: 512 NP--ADKPAWAREVEERTR----MNKQQNSPLAKSKPGSTGPEPPIPQA----------- 554
Query: 836 ELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSL 895
S SQ R +E + ++L+ RV + A RS+ SL
Sbjct: 555 ---------SPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ---SL 602
Query: 896 LERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSH 955
++ R + AF A + PAP P+ + ++ S
Sbjct: 603 QDQPTRNLAAFPA----------------SHDPDPAIPAPTATPSARGAVIRQNSDPTSE 646
Query: 956 GPPPPGMPPPAWRQPSLLAPPGPPNWLG----PPTQSGTPRGGALLLLRNSPQP------ 1005
G P P PPAW +P APP P SG +R P+
Sbjct: 647 G-PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQI 705
Query: 1006 -LRRAASGGSGSENVGPPAAAVPGPLSRSTS 1035
L+R A G+ + GPPA PGP + S++
Sbjct: 706 YLQRRAERGT-PKPPGPPAQP-PGPPNASSN 734
Score = 47.4 bits (111), Expect = 7e-05
Identities = 83/376 (22%), Positives = 148/376 (39%), Gaps = 68/376 (18%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T E +LQ ++ +E + Q Q L+ ++R+ E KH RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
+I++Q +E +++ +Q + L+ + + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
+ +L+E +++E L++QLQQE L + Q + Q +++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE--RLQRQLQQEHAYLKSLQ-------QQQQQQQLQKQQQ 493
Query: 865 RVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIP 924
+ L + L G + + R+ E + + S P
Sbjct: 494 QQLL------PGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGP 547
Query: 925 AEAAAQGYPAPP-PAPAWP--SRPV-PRSGAHWS---HGPPPPGMPPPAWRQPSLLAPP- 976
Q P PP P P RPV P+ G H S H P P R SL P
Sbjct: 548 EPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPT 607
Query: 977 ----------GPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSEN----VGPP 1022
P + PT + + RG ++R + P + G S N V P
Sbjct: 608 RNLAAFPASHDPDPAIPAPTATPSARGA---VIRQNSDP---TSEGPGPSPNPPAWVRPD 661
Query: 1023 AAAVPGPLSRSTSVAS 1038
A P R++S+A+
Sbjct: 662 NEAPPKVPQRTSSIAT 677
Score = 45.1 bits (105), Expect = 4e-04
Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 36/301 (11%)
Query: 510 ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHIL 569
ES LR E RLQ+E ++ + ++ Q + +++ R +A + H+L
Sbjct: 348 ESTLRRE----FLRLQQENKSN--------SEALKQQQQLQQQQQRDPEAHIK----HLL 391
Query: 570 GQQKKELAALLEAQKRTYKL-RKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEE 628
Q+++ + E ++R + R+E+ + +LQE R+ E +Q + EEE
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQ----------RRLEDMQALRREEE 441
Query: 629 AGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATR 688
R+++Y Q + ++ L R + + L ++Q Q+ L+ +Q +
Sbjct: 442 RRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ----KQQQQQLL 497
Query: 689 ELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSK-- 746
+ + L R + E+ + NK++ L + +P ++
Sbjct: 498 PGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG 557
Query: 747 ---ELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQY 803
L Q + Q +K+L AH + P A + L+++ TR LA +
Sbjct: 558 PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASH 617
Query: 804 D 804
D
Sbjct: 618 D 618
Score = 43.1 bits (100), Expect = 0.001
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 33/203 (16%)
Query: 737 RQQPKSLKSKELQIKK-QFQETCKIQTR----------QYKALRAHLLETTPKAQHK--- 782
R P LKSK+ K F +TC I+T ++ +R E + Q K
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 783 --SLLKRLKEEQTRKLAILAEQYDQSISE--------------MLSSQALRLDETQEAEF 826
S KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 827 QALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQT 886
+AL+QQ Q + + ++ IK H+R+ R EQ+ RR +QR E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 887 GRSERIRSLLERQAREIEAFDAE 909
+R ++ RE E AE
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 207 bits (527), Expect = 4e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 49.7 bits (117), Expect = 1e-05
Identities = 113/490 (23%), Positives = 188/490 (38%), Gaps = 86/490 (17%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR RE E RQ + Q + + Q Q+E
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALR-----REEERRQAEREQEYKRKQLEEQRQSE-- 463
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLET 775
R +++L+Q+HA KSL+ ++ Q + Q Q+ ++ K L +
Sbjct: 464 -------RLQRQLQQEHA-----YLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 776 TPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQ 835
P K R EE+TR + +Q + +++ +A
Sbjct: 512 NP--ADKPAWAREVEERTR----MNKQQNSPLAKSKPGSTGPEPPIPQA----------- 554
Query: 836 ELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSL 895
S SQ R +E + ++L+ RV + A RS+ SL
Sbjct: 555 ---------SPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ---SL 602
Query: 896 LERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSH 955
++ R + AF A + PAP P+ + ++ S
Sbjct: 603 QDQPTRNLAAFPA----------------SHDPDPAIPAPTATPSARGAVIRQNSDPTSE 646
Query: 956 GPPPPGMPPPAWRQPSLLAPPGPPNWLG----PPTQSGTPRGGALLLLRNSPQPLRRAAS 1011
G P P PPAW +P APP P SG +R S LRR+
Sbjct: 647 G-PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDP 705
Query: 1012 GGSGSENVGP 1021
G S++V P
Sbjct: 706 GWERSDSVLP 715
Score = 47.4 bits (111), Expect = 7e-05
Identities = 83/376 (22%), Positives = 148/376 (39%), Gaps = 68/376 (18%)
Query: 685 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 744
E+T E +LQ ++ +E + Q Q L+ ++R+ E KH RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 745 SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYD 804
+I++Q +E +++ +Q + L+ + + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 805 QSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQ 864
+ +L+E +++E L++QLQQE L + Q + Q +++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE--RLQRQLQQEHAYLKSLQ-------QQQQQQQLQKQQQ 493
Query: 865 RVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIP 924
+ L + L G + + R+ E + + S P
Sbjct: 494 QQLL------PGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGP 547
Query: 925 AEAAAQGYPAPP-PAPAWP--SRPV-PRSGAHWS---HGPPPPGMPPPAWRQPSLLAPP- 976
Q P PP P P RPV P+ G H S H P P R SL P
Sbjct: 548 EPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPT 607
Query: 977 ----------GPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSEN----VGPP 1022
P + PT + + RG ++R + P + G S N V P
Sbjct: 608 RNLAAFPASHDPDPAIPAPTATPSARGA---VIRQNSDP---TSEGPGPSPNPPAWVRPD 661
Query: 1023 AAAVPGPLSRSTSVAS 1038
A P R++S+A+
Sbjct: 662 NEAPPKVPQRTSSIAT 677
Score = 45.1 bits (105), Expect = 4e-04
Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 36/301 (11%)
Query: 510 ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHIL 569
ES LR E RLQ+E ++ + ++ Q + +++ R +A + H+L
Sbjct: 348 ESTLRRE----FLRLQQENKSN--------SEALKQQQQLQQQQQRDPEAHIK----HLL 391
Query: 570 GQQKKELAALLEAQKRTYKL-RKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEE 628
Q+++ + E ++R + R+E+ + +LQE R+ E +Q + EEE
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQ----------RRLEDMQALRREEE 441
Query: 629 AGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATR 688
R+++Y Q + ++ L R + + L ++Q Q+ L+ +Q +
Sbjct: 442 RRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ----KQQQQQLL 497
Query: 689 ELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSK-- 746
+ + L R + E+ + NK++ L + +P ++
Sbjct: 498 PGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG 557
Query: 747 ---ELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQY 803
L Q + Q +K+L AH + P A + L+++ TR LA +
Sbjct: 558 PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASH 617
Query: 804 D 804
D
Sbjct: 618 D 618
Score = 43.1 bits (100), Expect = 0.001
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 55/203 (27%), Positives = 84/203 (41%), Gaps = 33/203 (16%)
Query: 737 RQQPKSLKSKELQIKK-QFQETCKIQTR----------QYKALRAHLLETTPKAQHK--- 782
R P LKSK+ K F +TC I+T ++ +R E + Q K
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 783 --SLLKRLKEEQTRKLAILAEQYDQSISE--------------MLSSQALRLDETQEAEF 826
S KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 827 QALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQT 886
+AL+QQ Q + + ++ IK H+R+ R EQ+ RR +QR E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 887 GRSERIRSLLERQAREIEAFDAE 909
+R ++ RE E AE
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 207 bits (526), Expect = 5e-53
Identities = 118/322 (36%), Positives = 176/322 (54%), Gaps = 16/322 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DP F L+ +G G++G VY ARD SE+ A+K + Q +E+ L++
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQ---QEITILRE 67
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
RHPN + Y G YLR W+ ME+C G + + PL+E +IA V AL+GL +L
Sbjct: 68 CRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHL 127
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMD 198
HS IHRD+K N+LL+ G VKL DFG + + +A SF+GTPYWMAPEV
Sbjct: 128 HSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVER 187
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPVLQ-SGHWSEYFR 255
+G Y+ DVW+LGIT IEL E +PPLF+++ M AL ++++ + P L+ W++ F
Sbjct: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH 247
Query: 256 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKD------AVRELDNLQY 309
+F+ L K P+ RPT+E LL+H F ++ P ++ L+ + D + + + Y
Sbjct: 248 HFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETY 307
Query: 310 RKMKKILFQEAPNGPGAEAPEE 331
+ +GP P E
Sbjct: 308 DMFPDTIHSRGQHGPAERTPSE 329
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 206 bits (523), Expect = 1e-52
Identities = 153/437 (35%), Positives = 226/437 (51%), Gaps = 54/437 (12%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 AKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA ++ L+GLA+LH H++IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP---- 286
M AL+ I +N P L+S WS+ F +F++ CL K RP++E LLKH F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQ 297
Query: 287 -PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTL 345
+ D I RT+ E D +Y +E E PE+E E ++ G
Sbjct: 298 VRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGES 350
Query: 346 T-----------SLESSHSVPSMSISASSQSSSVNS-----LADASDNEEEEEEEEEEEE 389
T + E S ++ + Q LA+ E+++E+ E
Sbjct: 351 TLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE 410
Query: 390 EEEGPEAREMAMMQEGE 406
E++ E RE QE E
Sbjct: 411 EQQRRE-REARRQQERE 426
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 20/170 (11%)
Query: 538 EAEKLARRHQAIGEKEARAAQAEERKF---QQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E + RR Q + E++ R + +R+ +Q + QQK++ L E Q+R + R++Q
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+E+ + KR E R+KE+ ++ +AEEE + R+++Y Q + +R +
Sbjct: 425 REQ-RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL---- 479
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAE 704
L Q LL+E A+LL H +Q Q+ R++
Sbjct: 480 EVLQQQLLQEQ------------AMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 50.1 bits (118), Expect = 1e-05
Identities = 61/256 (23%), Positives = 115/256 (44%), Gaps = 30/256 (11%)
Query: 659 QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRT--RAELTRLQHQTELGN 716
+ LR D + Q Q++ E + LR+ + +E +LR+ + +R R++ Q E
Sbjct: 349 ESTLRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 717 QLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETT 776
+LE +RRE+E R RQQ + + +E + K++ +E + + + + RA +
Sbjct: 408 RLEEQQRREREAR-------RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 777 PKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQ--QLQ 834
+ + + + ++L+EEQ R L +L +Q +L QA+ L + + Q +Q Q
Sbjct: 461 VEREQEYIRRQLEEEQ-RHLEVLQQQ-------LLQEQAMLLHDHRRPHPQHSQQPPPPQ 512
Query: 835 QELELLNAYQSKIKIRTE-SQHERELREL---------EQRVALRRALLEQRVEEELLAL 884
QE + + + K E + RE+ + E + +LE V +
Sbjct: 513 QERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESF 572
Query: 885 QTGRSERIRSLLERQA 900
G SE + L+R A
Sbjct: 573 SNGNSESVHPALQRPA 588
Score = 47.0 bits (110), Expect = 9e-05
Identities = 46/173 (26%), Positives = 83/173 (47%), Gaps = 25/173 (14%)
Query: 467 ATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQ--HQKQLLALESRLRGEREEHSARL 524
+T+R L +Q + ++ R+QL +++R Q +++QLLA R +R E
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLA----ERQKRIEQQKEQ 405
Query: 525 QRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQK 584
+R LE Q+ E+ ARR Q ++ R Q E+R+ ++ ++++E E +K
Sbjct: 406 RRRLEEQQ-----RREREARRQQE--REQRRREQEEKRRLEELERRRKEEEERRRAEEEK 458
Query: 585 RTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
R + +E ++ +L+E R E LQQ +E+A LL R+
Sbjct: 459 RRVEREQEYIRRQLEEEQ------------RHLEVLQQQLLQEQAMLLHDHRR 499
Score = 43.5 bits (101), Expect = 0.001
Identities = 80/327 (24%), Positives = 119/327 (36%), Gaps = 43/327 (13%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR------QYKALRAHLL 773
Y +R E KH +R QP + +Q+K T K + +Y
Sbjct: 274 YMQRPSTEQLLKHPF-IRDQPNE-RQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE 331
Query: 774 ETTPKAQHKSLLKRLKEEQT-RKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQ 832
E + S + + E T R+ + +Q ++ SE L Q L L E Q E + ++Q
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQL-LQEQQLREQEEYKRQ 390
Query: 833 LQQELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSE 890
L E + Q + + R E Q ERE R ++R RR E+R EEL + E
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE 450
Query: 891 R----------------IRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPA 934
R IR LE + R +E + ++ + P +Q P
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPP 510
Query: 935 PPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQPSLLAPPGPPNWLGPPTQSGTPRGG 994
P + PS P AH+ PA R + N P QS + G
Sbjct: 511 PQQERSKPSFHAPEPKAHYE----------PADRAREVEDRFRKTNHSSPEAQS--KQTG 558
Query: 995 ALLLLRNSPQPLRRAASGGSGSENVGP 1021
+L P P R + SE+V P
Sbjct: 559 RVL---EPPVPSRSESFSNGNSESVHP 582
Score = 38.1 bits (87), Expect = 0.044
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 23/204 (11%)
Query: 585 RTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCR 644
RT K R E K+E + S + E+ E ++ E E+ L +R + LQ
Sbjct: 308 RTRKKRGE--KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTL---RRDFLRLQQE 362
Query: 645 QYKRKMLLARHSL--DQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTR 702
+R L R L +Q L ++ K+Q L RQ ++ E R+ Q+ R
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQL-------LAERQKRIEQQKEQRRRLEEQQRR 415
Query: 703 AELTRLQHQTELGNQLEYNKRREQELRQKHAAQ-----VRQQPKSLKSKELQIKKQFQET 757
R Q + E + + KRR +EL ++ + ++ + ++ ++ I++Q +E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE- 474
Query: 758 CKIQTRQYKALRAHLLETTPKAQH 781
+ R + L+ LL+ H
Sbjct: 475 ---EQRHLEVLQQQLLQEQAMLLH 495
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 206 bits (523), Expect = 1e-52
Identities = 153/437 (35%), Positives = 226/437 (51%), Gaps = 54/437 (12%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 AKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA ++ L+GLA+LH H++IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP---- 286
M AL+ I +N P L+S WS+ F +F++ CL K RP++E LLKH F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQ 297
Query: 287 -PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTL 345
+ D I RT+ E D +Y +E E PE+E E ++ G
Sbjct: 298 VRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGES 350
Query: 346 T-----------SLESSHSVPSMSISASSQSSSVNS-----LADASDNEEEEEEEEEEEE 389
T + E S ++ + Q LA+ E+++E+ E
Sbjct: 351 TLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE 410
Query: 390 EEEGPEAREMAMMQEGE 406
E++ E RE QE E
Sbjct: 411 EQQRRE-REARRQQERE 426
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 20/170 (11%)
Query: 538 EAEKLARRHQAIGEKEARAAQAEERKF---QQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E + RR Q + E++ R + +R+ +Q + QQK++ L E Q+R + R++Q
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+E+ + KR E R+KE+ ++ +AEEE + R+++Y Q + +R +
Sbjct: 425 REQ-RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL---- 479
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAE 704
L Q LL+E A+LL H +Q Q+ R++
Sbjct: 480 EVLQQQLLQEQ------------AMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 49.7 bits (117), Expect = 1e-05
Identities = 85/346 (24%), Positives = 124/346 (35%), Gaps = 35/346 (10%)
Query: 720 YNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTR------QYKALRAHLL 773
Y +R E KH +R QP + +Q+K T K + +Y
Sbjct: 274 YMQRPSTEQLLKHPF-IRDQPNE-RQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE 331
Query: 774 ETTPKAQHKSLLKRLKEEQT-RKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQ 832
E + S + + E T R+ + +Q ++ SE L Q L L E Q E + ++Q
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQL-LQEQQLREQEEYKRQ 390
Query: 833 LQQELELLNAYQSKIKIRTESQH--ERELRELEQRVALRRALLEQRVEEELLALQTGRSE 890
L E + Q + + R E Q ERE R ++R RR E+R EEL + E
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE 450
Query: 891 R----------------IRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPA 934
R IR LE + R +E + ++ + P +Q P
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPP 510
Query: 935 PPPAPAWPSRPVPRSGAHWSHGPPPPGMP-------PPAWRQPSLLAPPGPPNWLGPPTQ 987
P + PS P AH+ +P P R+ S L G N
Sbjct: 511 PQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRN 570
Query: 988 SGTPRGGALLLLRNSPQPLRRAASGGSGSENVGPPAAAVPGPLSRS 1033
S + LL R R + SGS N G + PG S S
Sbjct: 571 STSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGS 616
Score = 49.3 bits (116), Expect = 2e-05
Identities = 51/220 (23%), Positives = 101/220 (45%), Gaps = 18/220 (8%)
Query: 659 QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRT--RAELTRLQHQTELGN 716
+ LR D + Q Q++ E + LR+ + +E +LR+ + +R R++ Q E
Sbjct: 349 ESTLRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 717 QLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETT 776
+LE +RRE+E R RQQ + + +E + K++ +E + + + + RA +
Sbjct: 408 RLEEQQRREREAR-------RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 777 PKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQE 836
+ + + + ++L+EEQ R L +L +Q +L QA+ L + + Q +Q +
Sbjct: 461 VEREQEYIRRQLEEEQ-RHLEVLQQQ-------LLQEQAMLLHDHRRPHPQHSQQPPPPQ 512
Query: 837 LELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQR 876
E + + + RE+ R R +L +R
Sbjct: 513 QERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRR 552
Score = 47.0 bits (110), Expect = 9e-05
Identities = 46/173 (26%), Positives = 83/173 (47%), Gaps = 25/173 (14%)
Query: 467 ATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQ--HQKQLLALESRLRGEREEHSARL 524
+T+R L +Q + ++ R+QL +++R Q +++QLLA R +R E
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLA----ERQKRIEQQKEQ 405
Query: 525 QRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQK 584
+R LE Q+ E+ ARR Q ++ R Q E+R+ ++ ++++E E +K
Sbjct: 406 RRRLEEQQ-----RREREARRQQE--REQRRREQEEKRRLEELERRRKEEEERRRAEEEK 458
Query: 585 RTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
R + +E ++ +L+E R E LQQ +E+A LL R+
Sbjct: 459 RRVEREQEYIRRQLEEEQ------------RHLEVLQQQLLQEQAMLLHDHRR 499
Score = 38.1 bits (87), Expect = 0.044
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 23/204 (11%)
Query: 585 RTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCR 644
RT K R E K+E + S + E+ E ++ E E+ L +R + LQ
Sbjct: 308 RTRKKRGE--KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTL---RRDFLRLQQE 362
Query: 645 QYKRKMLLARHSL--DQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTR 702
+R L R L +Q L ++ K+Q L RQ ++ E R+ Q+ R
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQL-------LAERQKRIEQQKEQRRRLEEQQRR 415
Query: 703 AELTRLQHQTELGNQLEYNKRREQELRQKHAAQ-----VRQQPKSLKSKELQIKKQFQET 757
R Q + E + + KRR +EL ++ + ++ + ++ ++ I++Q +E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE- 474
Query: 758 CKIQTRQYKALRAHLLETTPKAQH 781
+ R + L+ LL+ H
Sbjct: 475 ---EQRHLEVLQQQLLQEQAMLLH 495
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 206 bits (523), Expect = 1e-52
Identities = 116/285 (40%), Positives = 175/285 (61%), Gaps = 12/285 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
+P++ F ++ IG G++G VY AR+V E+ AIK + + E + + +E+ ++
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKL---EPGEDFAVVQQEIIMMKD 67
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGLAY 141
+HPN + Y G YLR W+ ME+C G S D+ V PL E++IA V+ LQGL Y
Sbjct: 68 CKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV-TGPLSELQIAYVSRETLQGLYY 126
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFG-SASI---MAPANSFVGTPYWMAPEVILAM 197
LHS +HRD+K NILL++ G VKL DFG SA I +A SF+GTPYWMAPEV
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186
Query: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPVLQSG-HWSEYF 254
+G Y+ D+W++GIT IELAE +PP+F+++ M AL+ + ++ + P L+ WS F
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246
Query: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKD 299
+FV L K P+ RPT+E LL+H FV + ++ ++L+ + +
Sbjct: 247 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNN 291
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 199 bits (506), Expect = 1e-50
Identities = 148/443 (33%), Positives = 216/443 (48%), Gaps = 61/443 (13%)
Query: 12 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 71
DPD+ F DP + L+ +G G++G V+ ARD + ++VA+K + + ++
Sbjct: 5 DPDI----FNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM---EPDDDVS 57
Query: 72 DIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAA 130
+ KE+ L+ RH N + Y G YL W+ ME+C GS D+ +V L E++I+
Sbjct: 58 TLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGS-LSELQISY 116
Query: 131 VTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG-SASI---MAPANSFVGTP 186
V LQGLAYLHS IHRD+K NIL+++ G V+L DFG SA I +A SF+GTP
Sbjct: 117 VCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTP 176
Query: 187 YWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPV 244
YWMAPEV +G Y+ D+WSLGIT IELAE +PPLF+++ + L+ + ++ + P
Sbjct: 177 YWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPR 236
Query: 245 L-QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE-RPPTVIMDLIQRTKDAVR 302
L + G WS F NF+ L K P+ RP++ +L H+ V + +I+DL+ + K+ +
Sbjct: 237 LKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGK 296
Query: 303 ELDNLQYRKMKKILFQEAPNGPG-AEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISA 361
GP + +EE E P + R T SS +P
Sbjct: 297 --------------------GPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPD----- 331
Query: 362 SSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPG 421
AD E + E AR + + S S
Sbjct: 332 ----------ADCCRRHMEFRKLRGMETRPPANTAR-----LQPPRDLRSSSPRKQLSES 376
Query: 422 SDNLYDD---PYQPEITPSPLQP 441
SD+ YDD P E TP PL P
Sbjct: 377 SDDDYDDVDIPTPAEDTPPPLPP 399
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,920,048
Number of Sequences: 37866
Number of extensions: 2647666
Number of successful extensions: 57950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1447
Number of HSP's successfully gapped in prelim test: 2088
Number of HSP's that attempted gapping in prelim test: 21477
Number of HSP's gapped (non-prelim): 20007
length of query: 1049
length of database: 18,247,518
effective HSP length: 113
effective length of query: 936
effective length of database: 13,968,660
effective search space: 13074665760
effective search space used: 13074665760
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.