Search of human proteins with 4758668

Search of human proteins with 4758668

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4758668 serine palmitoyltransferase, long chain base subunit
2 [Homo sapiens]
         (562 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4758668 serine palmitoyltransferase, long chain base subunit ...  1137   0.0  
gi|119220554 serine palmitoyltransferase, long chain base subuni...   777   0.0  
gi|7657118 glycine C-acetyltransferase precursor [Homo sapiens]       187   3e-47
gi|5454084 serine palmitoyltransferase subunit 1 isoform a [Homo...   165   9e-41
gi|40316939 5-aminolevulinate synthase 1 [Homo sapiens]               156   4e-38
gi|4502025 5-aminolevulinate synthase 1 [Homo sapiens]                156   4e-38
gi|83977444 5-aminolevulinate synthase 2 isoform c precursor [Ho...   154   2e-37
gi|83977440 5-aminolevulinate synthase 2 isoform b precursor [Ho...   154   2e-37
gi|83977442 5-aminolevulinate synthase 2 isoform a precursor [Ho...   154   2e-37
gi|156151443 alpha-kinase 1 [Homo sapiens]                             32   1.2  
gi|156151441 alpha-kinase 1 [Homo sapiens]                             32   1.2  
gi|30474871 serine palmitoyltransferase subunit 1 isoform b [Hom...    32   2.0  
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       30   7.7  

>gi|4758668 serine palmitoyltransferase, long chain base subunit 2
           [Homo sapiens]
          Length = 562

 Score = 1137 bits (2941), Expect = 0.0
 Identities = 562/562 (100%), Positives = 562/562 (100%)

Query: 1   MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN 60
           MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
Sbjct: 1   MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN 60

Query: 61  EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN 120
           EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
Sbjct: 61  EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN 120

Query: 121 FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG 180
           FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
Sbjct: 121 FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG 180

Query: 181 FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA 240
           FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
Sbjct: 181 FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA 240

Query: 241 TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ 300
           TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
Sbjct: 241 TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ 300

Query: 301 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV 360
           PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
Sbjct: 301 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV 360

Query: 361 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII 420
           EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
Sbjct: 361 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII 420

Query: 421 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG 480
           TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
Sbjct: 421 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG 480

Query: 481 AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS 540
           AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
Sbjct: 481 AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS 540

Query: 541 RHRLVPLLDRPFDETTYEETED 562
           RHRLVPLLDRPFDETTYEETED
Sbjct: 541 RHRLVPLLDRPFDETTYEETED 562


>gi|119220554 serine palmitoyltransferase, long chain base subunit 3
           [Homo sapiens]
          Length = 552

 Score =  777 bits (2007), Expect = 0.0
 Identities = 383/546 (70%), Positives = 449/546 (82%), Gaps = 8/546 (1%)

Query: 18  GCVANGEVRNGYVRSSAAAAAAAAA-GQIHHVTQNGG--LYKRPFNEAFEETPMLVAVLT 74
           G V NG++ N   +S+ + +      G +    QNG    Y +   E+FEE P+ V V T
Sbjct: 7   GAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPLHVMVFT 66

Query: 75  YVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNW 134
           Y+GYG+ TLFGYLRDFLR W IEKC+ A ER+EQKDFV LYQDFENFYTRNLYMRIRDNW
Sbjct: 67  YMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNW 126

Query: 135 NRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAK 194
           NRPICS PG   D+MER S DYNW+F++TG +IK VINMGSYN+LG A            
Sbjct: 127 NRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKD 186

Query: 195 VLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGC 254
           VLE YG GV STR E+G LDKH+ELE+LVA+FL VEAAM +GMGFATNSMNIPALVGKGC
Sbjct: 187 VLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGC 246

Query: 255 LILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILV 314
           LILSDELNH SLVLGARLSGATIRIFKHNN QSLEKLL+DA++YGQPRTRR WKKILILV
Sbjct: 247 LILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILV 306

Query: 315 EGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMM 374
           EG+YSMEGSIV LP++IALKKKYKAYLY+DEAHSIGA+GPTGRGV E+FGLDP +VDV+M
Sbjct: 307 EGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLM 366

Query: 375 GTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSL 434
           GTFTKSFGASGGYI G+K+L+DYLR HSHSAVYA+S+SPP+ EQII S+K IMG DGT+ 
Sbjct: 367 GTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQ 426

Query: 435 GKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVV 494
           G + VQQLA+NTRYFR+RL+EMGFIIYGNE++ VVPL+LYMP K+ AF R ML++ IGVV
Sbjct: 427 GLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVV 486

Query: 495 VVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRP--F 552
           VVGFPATP+ E+RARFC+SAAHT+E+LDT L+ +DE+GDLLQLKYSRH+      RP  +
Sbjct: 487 VVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSA---RPELY 543

Query: 553 DETTYE 558
           DET++E
Sbjct: 544 DETSFE 549


>gi|7657118 glycine C-acetyltransferase precursor [Homo sapiens]
          Length = 419

 Score =  187 bits (474), Expect = 3e-47
 Identities = 125/367 (34%), Positives = 191/367 (52%), Gaps = 19/367 (5%)

Query: 169 GVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLG 228
           G++N  + NYLG + +    Q A  + LEE+GAG+ S R   G    H+ LE  +ARF  
Sbjct: 66  GILNFCANNYLGLSSHPEVIQ-AGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQ 124

Query: 229 VEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSL 288
            E A+ Y   +  N+    AL+     +LSDELNHAS++ G RL  A    ++H +M  L
Sbjct: 125 REDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADL 184

Query: 289 EKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHS 348
           E  L++A         +  +  L+  +G +SM+G I  L E+  L  +Y A +++DE H+
Sbjct: 185 EAKLQEA---------QKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHA 235

Query: 349 IGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSF-GASGGYIGGKKELIDYLRTHSHSAVY 407
            G LGPTGRG  E  G+  + V ++  T  K+  GASGGY  G   L+  LR  +   ++
Sbjct: 236 TGFLGPTGRGTDELLGV-MDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLF 294

Query: 408 ATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSP 467
           + SL P VV     ++  +MG +        VQ +A  T+ FR +++  GF I G    P
Sbjct: 295 SNSLPPAVVGCASKALDLLMGSN------TIVQSMAAKTQRFRSKMEAAGFTISG-ASHP 347

Query: 468 VVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKE 527
           + P+ML           +MLKR I V+   +P  P  ++R R  +SA H++E +D  ++ 
Sbjct: 348 ICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEA 407

Query: 528 IDEVGDL 534
             EVG L
Sbjct: 408 FVEVGRL 414


>gi|5454084 serine palmitoyltransferase subunit 1 isoform a [Homo
           sapiens]
          Length = 473

 Score =  165 bits (418), Expect = 9e-41
 Identities = 92/266 (34%), Positives = 149/266 (56%), Gaps = 4/266 (1%)

Query: 168 KGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFL 227
           K  IN  S+N+LG   N    + AA   L++YG G C  R   G  D H +LE+ +A+F+
Sbjct: 98  KECINFASFNFLGLLDNP-RVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFM 156

Query: 228 GVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQS 287
             E A+ Y  GFAT +  IPA   +G ++  D     ++  G + S + I++FKHN+M  
Sbjct: 157 KTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMAD 216

Query: 288 LEKLLKDAIVYGQ--PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 345
           LE+LLK+  +  Q  PR  R  ++ ++ VEG+Y   G+I  LPE++ LK KYKA ++L+E
Sbjct: 217 LERLLKEQEIEDQKNPRKARVTRRFIV-VEGLYMNTGTICPLPELVKLKYKYKARIFLEE 275

Query: 346 AHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSA 405
           + S G LG  GRGV E++G++ +D+D++      +  + GG+  G+  +ID+ R      
Sbjct: 276 SLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGY 335

Query: 406 VYATSLSPPVVEQIITSMKCIMGQDG 431
            ++ SL P +    I ++  +    G
Sbjct: 336 CFSASLPPLLAAAAIEALNIMEENPG 361


>gi|40316939 5-aminolevulinate synthase 1 [Homo sapiens]
          Length = 640

 Score =  156 bits (395), Expect = 4e-38
 Identities = 128/469 (27%), Positives = 229/469 (48%), Gaps = 36/469 (7%)

Query: 67  PMLVAVLTYVG--YGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTR 124
           P +V+V T  G   G+L  F   +D ++  R E+  H  +    K  VS +Q ++ F+ +
Sbjct: 151 PSVVSVKTDGGDPSGLLKNF---QDIMQKQRPERVSHLLQDNLPKS-VSTFQ-YDRFFEK 205

Query: 125 NLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNII--KGVINMGSYNYLGFA 182
            +  +  D+  R   +V         R++H +  +  Y+ ++I  K V    S +YLG +
Sbjct: 206 KIDEKKNDHTYRVFKTV--------NRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMS 257

Query: 183 RNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATN 242
           R+   C  A    L+++GAG   TR   G    H +LE  +A   G +AA+ +   F  N
Sbjct: 258 RHPRVCG-AVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVAN 316

Query: 243 SMNIPALVGK--GCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ 300
              +  L     GC I SD  NHAS++ G R S     IF+HN++  L +LL+ +     
Sbjct: 317 DSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRS----- 371

Query: 301 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV 360
                P    ++  E ++SM+G++  L E+  +  ++ A  ++DE H++G  G  G G+ 
Sbjct: 372 ----DPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIG 427

Query: 361 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII 420
           +  G+ P+ +D++ GT  K+FG  GGYI     LID +R+++   ++ TSL P ++   +
Sbjct: 428 DRDGVMPK-MDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGAL 486

Query: 421 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG 480
            S++ +   +G  L +    Q   N +  R+ L + G  +  +  S ++P+ +   AK  
Sbjct: 487 ESVRILKSAEGRVLRR----QHQRNVKLMRQMLMDAGLPVV-HCPSHIIPVRVADAAKNT 541

Query: 481 AFGREMLKR-NIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEI 528
               E++ R NI V  + +P  P  E   R   +  HT ++++  L+ +
Sbjct: 542 EVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENL 590


>gi|4502025 5-aminolevulinate synthase 1 [Homo sapiens]
          Length = 640

 Score =  156 bits (395), Expect = 4e-38
 Identities = 128/469 (27%), Positives = 229/469 (48%), Gaps = 36/469 (7%)

Query: 67  PMLVAVLTYVG--YGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTR 124
           P +V+V T  G   G+L  F   +D ++  R E+  H  +    K  VS +Q ++ F+ +
Sbjct: 151 PSVVSVKTDGGDPSGLLKNF---QDIMQKQRPERVSHLLQDNLPKS-VSTFQ-YDRFFEK 205

Query: 125 NLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNII--KGVINMGSYNYLGFA 182
            +  +  D+  R   +V         R++H +  +  Y+ ++I  K V    S +YLG +
Sbjct: 206 KIDEKKNDHTYRVFKTV--------NRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMS 257

Query: 183 RNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATN 242
           R+   C  A    L+++GAG   TR   G    H +LE  +A   G +AA+ +   F  N
Sbjct: 258 RHPRVCG-AVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVAN 316

Query: 243 SMNIPALVGK--GCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ 300
              +  L     GC I SD  NHAS++ G R S     IF+HN++  L +LL+ +     
Sbjct: 317 DSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRS----- 371

Query: 301 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV 360
                P    ++  E ++SM+G++  L E+  +  ++ A  ++DE H++G  G  G G+ 
Sbjct: 372 ----DPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIG 427

Query: 361 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII 420
           +  G+ P+ +D++ GT  K+FG  GGYI     LID +R+++   ++ TSL P ++   +
Sbjct: 428 DRDGVMPK-MDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGAL 486

Query: 421 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG 480
            S++ +   +G  L +    Q   N +  R+ L + G  +  +  S ++P+ +   AK  
Sbjct: 487 ESVRILKSAEGRVLRR----QHQRNVKLMRQMLMDAGLPVV-HCPSHIIPVRVADAAKNT 541

Query: 481 AFGREMLKR-NIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEI 528
               E++ R NI V  + +P  P  E   R   +  HT ++++  L+ +
Sbjct: 542 EVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENL 590


>gi|83977444 5-aminolevulinate synthase 2 isoform c precursor [Homo
           sapiens]
          Length = 574

 Score =  154 bits (390), Expect = 2e-37
 Identities = 103/364 (28%), Positives = 183/364 (50%), Gaps = 33/364 (9%)

Query: 175 SYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMA 234
           S +YLG +R+    Q A  + L+ +GAG   TR   G    H ELE+ +A     ++A+ 
Sbjct: 183 SNDYLGMSRHPQVLQ-ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALL 241

Query: 235 YGMGFATNSMNIPAL--VGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLL 292
           +   F  N   +  L  +  GC I SD  NHAS++ G R SGA   +F+HN+   L+KLL
Sbjct: 242 FSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL 301

Query: 293 KDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGAL 352
           + +          P    ++  E ++SM+G+I  L E+  +  +Y A  ++DE H++G  
Sbjct: 302 EKS---------NPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 352

Query: 353 GPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLS 412
           G  G G+ E  G+    +D++ GT  K+FG  GGYI   ++L+D +R+++   ++ TSL 
Sbjct: 353 GSRGAGIGERDGI-MHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLP 411

Query: 413 PPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLM 472
           P V+   + S++ + G++G +L +        N ++ R+ L + G         PV+P  
Sbjct: 412 PMVLSGALESVRLLKGEEGQALRR----AHQRNVKHMRQLLMDRGL--------PVIPCP 459

Query: 473 LY-MPAKIGAFGRE-------MLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 524
            + +P ++G            + K  I V  + +P  P  E   R   S  H+ ++++  
Sbjct: 460 SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDF 519

Query: 525 LKEI 528
           ++++
Sbjct: 520 VEKL 523


>gi|83977440 5-aminolevulinate synthase 2 isoform b precursor [Homo
           sapiens]
          Length = 550

 Score =  154 bits (390), Expect = 2e-37
 Identities = 103/364 (28%), Positives = 183/364 (50%), Gaps = 33/364 (9%)

Query: 175 SYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMA 234
           S +YLG +R+    Q A  + L+ +GAG   TR   G    H ELE+ +A     ++A+ 
Sbjct: 159 SNDYLGMSRHPQVLQ-ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALL 217

Query: 235 YGMGFATNSMNIPAL--VGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLL 292
           +   F  N   +  L  +  GC I SD  NHAS++ G R SGA   +F+HN+   L+KLL
Sbjct: 218 FSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL 277

Query: 293 KDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGAL 352
           + +          P    ++  E ++SM+G+I  L E+  +  +Y A  ++DE H++G  
Sbjct: 278 EKS---------NPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 328

Query: 353 GPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLS 412
           G  G G+ E  G+    +D++ GT  K+FG  GGYI   ++L+D +R+++   ++ TSL 
Sbjct: 329 GSRGAGIGERDGI-MHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLP 387

Query: 413 PPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLM 472
           P V+   + S++ + G++G +L +        N ++ R+ L + G         PV+P  
Sbjct: 388 PMVLSGALESVRLLKGEEGQALRR----AHQRNVKHMRQLLMDRGL--------PVIPCP 435

Query: 473 LY-MPAKIGAFGRE-------MLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 524
            + +P ++G            + K  I V  + +P  P  E   R   S  H+ ++++  
Sbjct: 436 SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDF 495

Query: 525 LKEI 528
           ++++
Sbjct: 496 VEKL 499


>gi|83977442 5-aminolevulinate synthase 2 isoform a precursor [Homo
           sapiens]
          Length = 587

 Score =  154 bits (390), Expect = 2e-37
 Identities = 103/364 (28%), Positives = 183/364 (50%), Gaps = 33/364 (9%)

Query: 175 SYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMA 234
           S +YLG +R+    Q A  + L+ +GAG   TR   G    H ELE+ +A     ++A+ 
Sbjct: 196 SNDYLGMSRHPQVLQ-ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALL 254

Query: 235 YGMGFATNSMNIPAL--VGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLL 292
           +   F  N   +  L  +  GC I SD  NHAS++ G R SGA   +F+HN+   L+KLL
Sbjct: 255 FSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL 314

Query: 293 KDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGAL 352
           + +          P    ++  E ++SM+G+I  L E+  +  +Y A  ++DE H++G  
Sbjct: 315 EKS---------NPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 365

Query: 353 GPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLS 412
           G  G G+ E  G+    +D++ GT  K+FG  GGYI   ++L+D +R+++   ++ TSL 
Sbjct: 366 GSRGAGIGERDGI-MHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLP 424

Query: 413 PPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLM 472
           P V+   + S++ + G++G +L +        N ++ R+ L + G         PV+P  
Sbjct: 425 PMVLSGALESVRLLKGEEGQALRR----AHQRNVKHMRQLLMDRGL--------PVIPCP 472

Query: 473 LY-MPAKIGAFGRE-------MLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 524
            + +P ++G            + K  I V  + +P  P  E   R   S  H+ ++++  
Sbjct: 473 SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDF 532

Query: 525 LKEI 528
           ++++
Sbjct: 533 VEKL 536


>gi|156151443 alpha-kinase 1 [Homo sapiens]
          Length = 1244

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 34/132 (25%), Positives = 53/132 (40%), Gaps = 9/132 (6%)

Query: 415 VVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLY 474
           V++Q++     +  +D  S  + C   L    R   +  KEM +        P VP    
Sbjct: 17  VLDQLLLEAPDVSEED-KSEDQRCRALLPSELRTLIQEAKEMKW--------PFVPEKWQ 67

Query: 475 MPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDL 534
               +G   +  LK  IG  +    A+      AR C +AA    ++D  L  +D  G L
Sbjct: 68  YKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKL 127

Query: 535 LQLKYSRHRLVP 546
           LQ+    H+L P
Sbjct: 128 LQVAKGLHKLQP 139


>gi|156151441 alpha-kinase 1 [Homo sapiens]
          Length = 1244

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 34/132 (25%), Positives = 53/132 (40%), Gaps = 9/132 (6%)

Query: 415 VVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLY 474
           V++Q++     +  +D  S  + C   L    R   +  KEM +        P VP    
Sbjct: 17  VLDQLLLEAPDVSEED-KSEDQRCRALLPSELRTLIQEAKEMKW--------PFVPEKWQ 67

Query: 475 MPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDL 534
               +G   +  LK  IG  +    A+      AR C +AA    ++D  L  +D  G L
Sbjct: 68  YKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKL 127

Query: 535 LQLKYSRHRLVP 546
           LQ+    H+L P
Sbjct: 128 LQVAKGLHKLQP 139


>gi|30474871 serine palmitoyltransferase subunit 1 isoform b [Homo
           sapiens]
          Length = 143

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 17/47 (36%), Positives = 23/47 (48%), Gaps = 1/47 (2%)

Query: 168 KGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLD 214
           K  IN  S+N+LG   N    + AA   L++YG G C  R   G  +
Sbjct: 98  KECINFASFNFLGLLDNP-RVKAAALASLKKYGVGTCGPRGFYGTFE 143


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 29.6 bits (65), Expect = 7.7
 Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 13/70 (18%)

Query: 247  PALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRP 306
            PA VGK  L+           L A L+G T++I   N+     +LL     + Q    RP
Sbjct: 2067 PASVGKTSLVQ----------LLAHLTGHTLKIMAMNSAMDTTELLGG---FEQVDLIRP 2113

Query: 307  WKKILILVEG 316
            W+++L  VEG
Sbjct: 2114 WRRLLEKVEG 2123


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,302,935
Number of Sequences: 37866
Number of extensions: 933252
Number of successful extensions: 2341
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2305
Number of HSP's gapped (non-prelim): 15
length of query: 562
length of database: 18,247,518
effective HSP length: 107
effective length of query: 455
effective length of database: 14,195,856
effective search space: 6459114480
effective search space used: 6459114480
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.