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Search of human proteins with 4758222
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1B isoform a [Homo sapiens]
(629 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 1295 0.0
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 1221 0.0
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 1191 0.0
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 757 0.0
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 754 0.0
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 746 0.0
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 737 0.0
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 731 0.0
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 290 4e-78
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 283 4e-76
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 283 4e-76
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 274 2e-73
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 274 2e-73
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 218 1e-56
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 218 1e-56
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 210 3e-54
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 210 3e-54
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 208 1e-53
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 208 1e-53
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 195 9e-50
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 178 2e-44
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 178 2e-44
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 176 4e-44
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 176 4e-44
gi|47717134 CDC-like kinase 2 [Homo sapiens] 175 1e-43
gi|10190706 CDC-like kinase 4 [Homo sapiens] 174 2e-43
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 172 1e-42
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 139 8e-33
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 139 8e-33
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 138 2e-32
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 1295 bits (3350), Expect = 0.0
Identities = 629/629 (100%), Positives = 629/629 (100%)
Query: 1 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
Sbjct: 1 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
Query: 61 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
Sbjct: 61 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
Query: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
Sbjct: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
Query: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
Sbjct: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
Query: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
Sbjct: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
Query: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
Sbjct: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
Query: 361 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 420
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
Sbjct: 361 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 420
Query: 421 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 480
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
Sbjct: 421 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 480
Query: 481 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 540
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
Sbjct: 481 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 540
Query: 541 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 600
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
Sbjct: 541 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 600
Query: 601 PPLPPPDDPATLGPHLGLRGVPQSTAASS 629
PPLPPPDDPATLGPHLGLRGVPQSTAASS
Sbjct: 601 PPLPPPDDPATLGPHLGLRGVPQSTAASS 629
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 1221 bits (3158), Expect = 0.0
Identities = 601/629 (95%), Positives = 601/629 (95%), Gaps = 28/629 (4%)
Query: 1 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
Sbjct: 1 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
Query: 61 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
Sbjct: 61 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
Query: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
Sbjct: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
Query: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
Sbjct: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
Query: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
Sbjct: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
Query: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
Sbjct: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
Query: 361 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 420
KELRKDYQGPGTRRLQE DLVLRMLEYEPAARI
Sbjct: 361 KELRKDYQGPGTRRLQE----------------------------DLVLRMLEYEPAARI 392
Query: 421 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 480
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
Sbjct: 393 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 452
Query: 481 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 540
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
Sbjct: 453 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 512
Query: 541 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 600
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
Sbjct: 513 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 572
Query: 601 PPLPPPDDPATLGPHLGLRGVPQSTAASS 629
PPLPPPDDPATLGPHLGLRGVPQSTAASS
Sbjct: 573 PPLPPPDDPATLGPHLGLRGVPQSTAASS 601
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 1191 bits (3080), Expect = 0.0
Identities = 589/629 (93%), Positives = 589/629 (93%), Gaps = 40/629 (6%)
Query: 1 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
Sbjct: 1 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 60
Query: 61 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
Sbjct: 61 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 120
Query: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
Sbjct: 121 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 180
Query: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
Sbjct: 181 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 240
Query: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
Sbjct: 241 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 300
Query: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
Sbjct: 301 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 360
Query: 361 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 420
KELRK DLVLRMLEYEPAARI
Sbjct: 361 KELRK----------------------------------------DLVLRMLEYEPAARI 380
Query: 421 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 480
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
Sbjct: 381 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 440
Query: 481 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 540
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
Sbjct: 441 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 500
Query: 541 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 600
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
Sbjct: 501 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 560
Query: 601 PPLPPPDDPATLGPHLGLRGVPQSTAASS 629
PPLPPPDDPATLGPHLGLRGVPQSTAASS
Sbjct: 561 PPLPPPDDPATLGPHLGLRGVPQSTAASS 589
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 757 bits (1955), Expect = 0.0
Identities = 377/509 (74%), Positives = 431/509 (84%), Gaps = 10/509 (1%)
Query: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS
Sbjct: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
Query: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
+KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG 380
QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LG
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
Query: 381 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440
V+TGGPGGRRAGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
Query: 441 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 494
T +S STSPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG
Sbjct: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545
Query: 495 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 522
DCE +SPQV P W+G + P
Sbjct: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 754 bits (1946), Expect = 0.0
Identities = 373/493 (75%), Positives = 425/493 (86%), Gaps = 9/493 (1%)
Query: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS
Sbjct: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
Query: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
+KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG 380
QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LG
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
Query: 381 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440
V+TGGPGGRRAGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
Query: 441 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 494
T +S STSPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG
Sbjct: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545
Query: 495 PPITDCEMNSPQV 507
DCE +SPQV
Sbjct: 546 VQAMDCETHSPQV 558
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 746 bits (1926), Expect = 0.0
Identities = 372/499 (74%), Positives = 423/499 (84%), Gaps = 10/499 (2%)
Query: 31 RRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNH 90
RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS+KKE+KV N
Sbjct: 70 RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND 129
Query: 91 GYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLN 150
GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIKIIKNKKAFLN
Sbjct: 130 GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLN 189
Query: 151 QAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS 210
QAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDLLRNT+FRGVS
Sbjct: 190 QAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS 249
Query: 211 LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 270
LNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI
Sbjct: 250 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 309
Query: 271 YQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG 330
YQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVDQMN+IVEVLG
Sbjct: 310 YQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG 369
Query: 331 IPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRR 390
IPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LGV+TGGPGGRR
Sbjct: 370 IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR 429
Query: 391 AGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 450
AGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TNT +S ST
Sbjct: 430 AGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVST 486
Query: 451 SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PGPPITDCEMNS 504
SPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG DCE +S
Sbjct: 487 SPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHS 546
Query: 505 PQVPPSQPL-RPWAGGDVP 522
PQV P W+G + P
Sbjct: 547 PQVRQQFPAPLGWSGTEAP 565
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 737 bits (1903), Expect = 0.0
Identities = 362/465 (77%), Positives = 409/465 (87%), Gaps = 4/465 (0%)
Query: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS
Sbjct: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
Query: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
+KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG 380
QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LG
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
Query: 381 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440
V+TGGPGGRRAGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
Query: 441 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRY 485
T +S STSPA ++ SS T SS SSS G+S S + R+
Sbjct: 489 T---SNSVSTSPA-MEQSQSSGTTSSTSSSSGASAISCSSWLVRH 529
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 731 bits (1888), Expect = 0.0
Identities = 358/450 (79%), Positives = 402/450 (89%), Gaps = 4/450 (0%)
Query: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80
QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS
Sbjct: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
Query: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140
+KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200
IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
Query: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
Query: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG 380
QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LG
Sbjct: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
Query: 381 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440
V+TGGPGGRRAGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TN
Sbjct: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
Query: 441 TGPAGSSASTSPAPLDTCPSSSTASSISSS 470
T +S STSPA ++ SS T SS SSS
Sbjct: 489 T---SNSVSTSPA-MEQSQSSGTTSSTSSS 514
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 290 bits (741), Expect = 4e-78
Identities = 165/417 (39%), Positives = 241/417 (57%), Gaps = 27/417 (6%)
Query: 41 TSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYI 100
T+A KL + + Y+ + YA+ +A D++ +K K +DD++ Y+
Sbjct: 37 TAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKT---SFDDEHGFYL 93
Query: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
+ RYE+ IGKGSFGQV K DH+ ELVA+KII+NKK F QA +EL++LE
Sbjct: 94 KVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILE 153
Query: 161 LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ 220
+ + D + Y +VH+K F FRNH C+ FELL NLY+L++N +F+G SL++ R+
Sbjct: 154 ALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLS 213
Query: 221 LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 280
+ L L+ + IIHCDLKPENI+L ++++K++DFGSSC Q++Y YIQSRFYR
Sbjct: 214 VLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYR 271
Query: 281 SPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA 340
SPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I+EVLG+PPA + A
Sbjct: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331
Query: 341 PKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPAD 400
+ + +F+ G+ T R + P ++ L VL
Sbjct: 332 SRRQTFFD---SKGFPKNITNN-RGKKRYPDSKDLTMVLKTYD----------------- 370
Query: 401 YLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDT 457
F D + R L +EP+ R++P AL+H + ++ + P S S P +T
Sbjct: 371 -TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSET 426
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 283 bits (723), Expect = 4e-76
Identities = 168/398 (42%), Positives = 229/398 (57%), Gaps = 23/398 (5%)
Query: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
N GYDDD Y+ + RYE+ +IGKGSFGQVVKAYDH+ + VA+K+++N+K F
Sbjct: 200 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 259
Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
QA E+R+LE + + D + ++H+ +F FRNH+C+ FELLS NLY+L++ F+G
Sbjct: 260 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 319
Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
SL L RK A + L A + IIHCDLKPENILL RS IK++DFGSSC Q
Sbjct: 320 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 377
Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
R+Y YIQSRFYR+PEV+LG Y + IDMWSLGCIL E+ TG PL G +E DQ+ ++E+
Sbjct: 378 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 437
Query: 329 LGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKD----YQGPGTRRLQEVLGVQTG 384
LG+P +LD + +A+ + + G+ T D G +RR G G
Sbjct: 438 LGMPSQKLLDASKRAKNF---VSSKGYPRYCTVTTLSDGSVVLNGGRSRR-----GKLRG 489
Query: 385 GPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPA 444
P R G D L F D + + LE++PA R++P AL+H + RR + P
Sbjct: 490 PPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PT 544
Query: 445 GSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRT 482
G S S+ +SIS S S+S RT
Sbjct: 545 GEKTSVK----RITESTGAITSISKLPPPSSSASKLRT 578
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 283 bits (723), Expect = 4e-76
Identities = 168/398 (42%), Positives = 229/398 (57%), Gaps = 23/398 (5%)
Query: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
N GYDDD Y+ + RYE+ +IGKGSFGQVVKAYDH+ + VA+K+++N+K F
Sbjct: 127 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 186
Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
QA E+R+LE + + D + ++H+ +F FRNH+C+ FELLS NLY+L++ F+G
Sbjct: 187 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 246
Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
SL L RK A + L A + IIHCDLKPENILL RS IK++DFGSSC Q
Sbjct: 247 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 304
Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
R+Y YIQSRFYR+PEV+LG Y + IDMWSLGCIL E+ TG PL G +E DQ+ ++E+
Sbjct: 305 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 364
Query: 329 LGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKD----YQGPGTRRLQEVLGVQTG 384
LG+P +LD + +A+ + + G+ T D G +RR G G
Sbjct: 365 LGMPSQKLLDASKRAKNF---VSSKGYPRYCTVTTLSDGSVVLNGGRSRR-----GKLRG 416
Query: 385 GPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPA 444
P R G D L F D + + LE++PA R++P AL+H + RR + P
Sbjct: 417 PPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PT 471
Query: 445 GSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRT 482
G S S+ +SIS S S+S RT
Sbjct: 472 GEKTSVK----RITESTGAITSISKLPPPSSSASKLRT 505
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 274 bits (700), Expect = 2e-73
Identities = 150/355 (42%), Positives = 221/355 (62%), Gaps = 11/355 (3%)
Query: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
N GYDD + YI + RYE+ +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 167 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 226
Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
QA E+R+LE + + D ++H+ F FRNH+C+ FELLS +LY+L++ F+G
Sbjct: 227 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 286
Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
S+ L RK AQ + +L A + IIHCDLKPENILL + RS+ K++DFGSSC Q
Sbjct: 287 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 344
Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
++Y YIQSRFYR+PE++LG+ Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+
Sbjct: 345 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 404
Query: 329 LGIPPAAMLDQAPKARKYFERLPG--GGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386
LG+PP +L+Q+ +A KYF G ++ + R G +RR G + G P
Sbjct: 405 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRR-----GKKRGPP 458
Query: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 441
G + G DYL F + + R L ++P+AR++P AL+H + ++ T
Sbjct: 459 GSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 512
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 274 bits (700), Expect = 2e-73
Identities = 150/355 (42%), Positives = 221/355 (62%), Gaps = 11/355 (3%)
Query: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
N GYDD + YI + RYE+ +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
Query: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
QA E+R+LE + + D ++H+ F FRNH+C+ FELLS +LY+L++ F+G
Sbjct: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
Query: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
S+ L RK AQ + +L A + IIHCDLKPENILL + RS+ K++DFGSSC Q
Sbjct: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
Query: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
++Y YIQSRFYR+PE++LG+ Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+
Sbjct: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
Query: 329 LGIPPAAMLDQAPKARKYFERLPG--GGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386
LG+PP +L+Q+ +A KYF G ++ + R G +RR G + G P
Sbjct: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRR-----GKKRGPP 478
Query: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 441
G + G DYL F + + R L ++P+AR++P AL+H + ++ T
Sbjct: 479 GSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 218 bits (556), Expect = 1e-56
Identities = 126/339 (37%), Positives = 189/339 (55%), Gaps = 22/339 (6%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQV K + T+E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
Query: 348 ERLPGGGWTLRRTK-----ELRKDYQGPGTRRL-------QEVLGVQTGGPGGRRAGEPG 395
R P G+ L R K EL + R+ + + T G E
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAE-- 484
Query: 396 HSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434
AD + DL+ +ML + RI+PL L H F T
Sbjct: 485 --KADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 218 bits (556), Expect = 1e-56
Identities = 126/339 (37%), Positives = 189/339 (55%), Gaps = 22/339 (6%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQV K + T+E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
Query: 348 ERLPGGGWTLRRTK-----ELRKDYQGPGTRRL-------QEVLGVQTGGPGGRRAGEPG 395
R P G+ L R K EL + R+ + + T G E
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAE-- 484
Query: 396 HSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434
AD + DL+ +ML + RI+PL L H F T
Sbjct: 485 --KADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 210 bits (535), Expect = 3e-54
Identities = 123/337 (36%), Positives = 184/337 (54%), Gaps = 18/337 (5%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
Query: 348 ERLPGGGWTLRRTK-----ELRKDYQGPGTRR-----LQEVLGVQTGGPGGRRAGEPGHS 397
R + L R K E + R+ L ++ Q +
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDM--AQVNMTTDLEGSDMLVE 493
Query: 398 PADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434
AD F DL+ +ML + RI+P+ L H F T
Sbjct: 494 KADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 210 bits (535), Expect = 3e-54
Identities = 123/337 (36%), Positives = 184/337 (54%), Gaps = 18/337 (5%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
P+ AIDMWSLGC++ E+ G PL+ G++E DQ+ I + G+P +L K ++F
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
Query: 348 ERLPGGGWTLRRTK-----ELRKDYQGPGTRR-----LQEVLGVQTGGPGGRRAGEPGHS 397
R + L R K E + R+ L ++ Q +
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDM--AQVNMTTDLEGSDMLVE 493
Query: 398 PADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434
AD F DL+ +ML + RI+P+ L H F T
Sbjct: 494 KADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 208 bits (529), Expect = 1e-53
Identities = 125/337 (37%), Positives = 188/337 (55%), Gaps = 26/337 (7%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F RNH CLVFE+L NLYD L+ F + L + R + QQ+ TAL L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
P+ AIDMWSLGC++ E+ G PL+ G+ E DQ+ I + G+P +L+ K+ ++F
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
Query: 348 ER---LPGGGWTLR-----------RTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGE 393
+ + GW L+ ++KE RK L +V V T +
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYI----FNSLDDVAHVNT--VMDLEGSD 487
Query: 394 PGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGF 430
AD F L+ +ML + RI+P L H F
Sbjct: 488 LLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 208 bits (529), Expect = 1e-53
Identities = 125/337 (37%), Positives = 188/337 (55%), Gaps = 26/337 (7%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F RNH CLVFE+L NLYD L+ F + L + R + QQ+ TAL L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
P+ AIDMWSLGC++ E+ G PL+ G+ E DQ+ I + G+P +L+ K+ ++F
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
Query: 348 ER---LPGGGWTLR-----------RTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGE 393
+ + GW L+ ++KE RK L +V V T +
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYI----FNSLDDVAHVNT--VMDLEGSD 487
Query: 394 PGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGF 430
AD F L+ +ML + RI+P L H F
Sbjct: 488 LLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 195 bits (496), Expect = 9e-50
Identities = 133/353 (37%), Positives = 191/353 (54%), Gaps = 26/353 (7%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Y+I ++GKG+FG+V K + T E+VAIKI+KN + EL+LL M D E +
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE-E 69
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
+++ F LVFELL NL++ + +F + R + Q+ TAL L
Sbjct: 70 AHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK- 128
Query: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPEVL 285
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE+L
Sbjct: 129 -ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEIL 187
Query: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARK 345
LG P+ +D+WSLGC++ E+H G PL+ G+NE DQ+ I E G+P +L A KA
Sbjct: 188 LGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHH 247
Query: 346 YFERLP----GGGWTLRRTKE-LRKDYQGPGTRR---LQEVLGVQT--GGPGGRRAGEPG 395
+F+R P W L+ + + L + P RR L+ + ++T GG R P
Sbjct: 248 FFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPD 307
Query: 396 HSP----ADYLRFQDLVLRMLEYEPAARISPLGALQHGFFR----RTADEATN 440
AD +L+ RML +E RISP AL+H F R+A E T+
Sbjct: 308 REALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 178 bits (451), Expect = 2e-44
Identities = 124/404 (30%), Positives = 198/404 (49%), Gaps = 65/404 (16%)
Query: 55 TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
+YK + ++++ RR S K ++ +DD +++ +SG+ RYEI
Sbjct: 154 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 205
Query: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
+G+G+FG+VV+ DH+ VA+KI+KN + A+ E+++LE +N D +
Sbjct: 206 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 265
Query: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
V + F H+C+VFELL + YD ++ F L+ RK+A Q+C ++ FL + +
Sbjct: 266 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 325
Query: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
L+ H DLKPENIL NPK IK+VDFGS+ + +
Sbjct: 326 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 383
Query: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
+R YR+PEV+L + D+WS+GCIL+E + G +F + + + + +LG P
Sbjct: 384 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 443
Query: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPG 387
M+ Q + RKYF E G + RR K L++ Q+V
Sbjct: 444 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLS------QDV--------- 487
Query: 388 GRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
++ R DL+ +MLEY+PA RI+ AL+H FF
Sbjct: 488 ------------EHERLFDLIQKMLEYDPAKRITLREALKHPFF 519
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 178 bits (451), Expect = 2e-44
Identities = 124/404 (30%), Positives = 198/404 (49%), Gaps = 65/404 (16%)
Query: 55 TYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEI 113
+YK + ++++ RR S K ++ +DD +++ +SG+ RYEI
Sbjct: 112 SYKSKHRIHHSTSHRR--------SHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEI 163
Query: 114 DSLIGKGSFGQVVKAYDHQTQ-ELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYY 172
+G+G+FG+VV+ DH+ VA+KI+KN + A+ E+++LE +N D +
Sbjct: 164 VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFR 223
Query: 173 IVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPE 232
V + F H+C+VFELL + YD ++ F L+ RK+A Q+C ++ FL + +
Sbjct: 224 CVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 283
Query: 233 LSIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQ 275
L+ H DLKPENIL NPK IK+VDFGS+ + +
Sbjct: 284 LT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVS 341
Query: 276 SRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAA 335
+R YR+PEV+L + D+WS+GCIL+E + G +F + + + + +LG P
Sbjct: 342 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 401
Query: 336 MLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPG 387
M+ Q + RKYF E G + RR K L++ Q+V
Sbjct: 402 MI-QKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLS------QDV--------- 445
Query: 388 GRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
++ R DL+ +MLEY+PA RI+ AL+H FF
Sbjct: 446 ------------EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 176 bits (447), Expect = 4e-44
Identities = 127/405 (31%), Positives = 200/405 (49%), Gaps = 61/405 (15%)
Query: 54 KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
+T KH + + KRR + S +++ K + +DD ++V R G+ ERYE
Sbjct: 250 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 305
Query: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
I +G+G+FG+VV+ DH + + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 306 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 365
Query: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
V + F F H+C+ FELL N ++ L+ +F+ L R +A QLC AL FL
Sbjct: 366 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 425
Query: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 426 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 483
Query: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
+R YR PEV+L + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 484 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 543
Query: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386
M+ + K +KYF E G + K L K Y LQ+ L
Sbjct: 544 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPL-KSYM------LQDSL------- 588
Query: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
++++ DL+ RMLE++PA RI+ AL H FF
Sbjct: 589 -------------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 620
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 176 bits (447), Expect = 4e-44
Identities = 127/405 (31%), Positives = 200/405 (49%), Gaps = 61/405 (15%)
Query: 54 KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
+T KH + + KRR + S +++ K + +DD ++V R G+ ERYE
Sbjct: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
Query: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
I +G+G+FG+VV+ DH + + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
Query: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
V + F F H+C+ FELL N ++ L+ +F+ L R +A QLC AL FL
Sbjct: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
Query: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
Query: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
+R YR PEV+L + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
Query: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386
M+ + K +KYF E G + K L K Y LQ+ L
Sbjct: 396 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPL-KSYM------LQDSL------- 440
Query: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
++++ DL+ RMLE++PA RI+ AL H FF
Sbjct: 441 -------------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 175 bits (444), Expect = 1e-43
Identities = 121/404 (29%), Positives = 198/404 (49%), Gaps = 61/404 (15%)
Query: 64 YAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWL-ERYEIDSLIGKGSF 122
+ +++RR++ S + + K + +DD +++ WL ERYEI S +G+G+F
Sbjct: 118 HRRRRRRSRTFSRSSSHSSRRAKSV----EDDAEGHLIYHVGDWLQERYEIVSTLGEGTF 173
Query: 123 GQVVKAYDHQT-QELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFM 181
G+VV+ DH+ VA+KIIKN + + A++E+ +LE +N+ D + K V + F
Sbjct: 174 GRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFD 233
Query: 182 FRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLK 241
+ H+C+ FELL + +D L++ ++ ++ R +A QLC A+ FL +L+ H DLK
Sbjct: 234 YHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLK 291
Query: 242 PENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEV 284
PENIL N K +A+++VDFGS+ + + +R YR+PEV
Sbjct: 292 PENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEV 351
Query: 285 LLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKAR 344
+L + D+WS+GCI+ E + G LF + + + + +LG P+ M+ + K +
Sbjct: 352 ILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRK-Q 410
Query: 345 KYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGH 396
KYF E G + K LR+
Sbjct: 411 KYFYRGRLDWDENTSAGRYVRENCKPLRRYLTS--------------------------- 443
Query: 397 SPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440
++ + DL+ MLEYEPA R++ ALQH FF R E N
Sbjct: 444 EAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 174 bits (441), Expect = 2e-43
Identities = 117/392 (29%), Positives = 189/392 (48%), Gaps = 57/392 (14%)
Query: 67 KKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEIDSLIGKGSFGQV 125
K++R + S +K ++ + +DD +++ +SG+ RYEI +G+G+FG+V
Sbjct: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
Query: 126 VKAYDHQTQEL-VAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRN 184
V+ DH + VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
Query: 185 HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN 244
H+C+VFELL + YD ++ F ++ R++A Q+C ++ FL +L+ H DLKPEN
Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291
Query: 245 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 287
IL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351
Query: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
+ D+WS+GCIL+E + G +F + + + + +LG P M+ Q + RKYF
Sbjct: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMI-QKTRKRKYF 410
Query: 348 --------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPA 399
E G + RR K L++
Sbjct: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFML---------------------------CHDE 443
Query: 400 DYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
++ + DLV RMLEY+P RI+ ALQH FF
Sbjct: 444 EHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 475
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 172 bits (435), Expect = 1e-42
Identities = 119/358 (33%), Positives = 183/358 (51%), Gaps = 20/358 (5%)
Query: 83 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDH-QTQELVAIKI 141
KE L + D Y V GE +RY + G+G F VV+A D+ + + VA+KI
Sbjct: 659 KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKI 718
Query: 142 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201
I+N + EL L+ +N D + K++ + L RHF + HLCLVFE LS NL ++L
Sbjct: 719 IRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVL 778
Query: 202 RNTHFR-GVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
+ G+ + R +QQL AL L +I+H D+KP+NIL+ N ++ +K+ DF
Sbjct: 779 KKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNILV-NESKTILKLCDF 835
Query: 261 GSSCQLGQR-IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEV 319
GS+ + I Y+ SRFYR+PE+++G YD IDMWS+GC L E++TG+ LF G
Sbjct: 836 GSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNN 895
Query: 320 DQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGW-----TLRRTKELRKDYQGPGTRR 374
+ +++ G P M+ + ++F++ + R K P
Sbjct: 896 HMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDL 955
Query: 375 LQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFR 432
L +++G Q R E L+ DL+ ++L +PA RIS ALQH F +
Sbjct: 956 LADLIGCQ-------RLPEDQRKKVHQLK--DLLDQILMLDPAKRISINQALQHAFIQ 1004
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 139 bits (350), Expect = 8e-33
Identities = 84/234 (35%), Positives = 134/234 (57%), Gaps = 12/234 (5%)
Query: 108 LERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDT 167
+ ++EI ++G+G++G V+K +T E+VAIK K+ + + LR L+++ T
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66
Query: 168 EMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLF 227
+ IV LK F R L LVFE + N+ +LL GV + QL A+ +
Sbjct: 67 LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125
Query: 228 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 283
+ I+H D+KPEN+L+ + +K+ DFG + L + +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181
Query: 284 VLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAML 337
+LLG PY ++DMWS+GCIL E+ G+PLF G +E+DQ+ I +VLG P+ +
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQM 235
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 139 bits (350), Expect = 8e-33
Identities = 84/234 (35%), Positives = 134/234 (57%), Gaps = 12/234 (5%)
Query: 108 LERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDT 167
+ ++EI ++G+G++G V+K +T E+VAIK K+ + + LR L+++ T
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66
Query: 168 EMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLF 227
+ IV LK F R L LVFE + N+ +LL GV + QL A+ +
Sbjct: 67 LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125
Query: 228 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 283
+ I+H D+KPEN+L+ + +K+ DFG + L + +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181
Query: 284 VLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAML 337
+LLG PY ++DMWS+GCIL E+ G+PLF G +E+DQ+ I +VLG P+ +
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQM 235
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 138 bits (347), Expect = 2e-32
Identities = 73/173 (42%), Positives = 107/173 (61%), Gaps = 6/173 (3%)
Query: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
Query: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Y V F +NH CLVFE+L NLYD L+ F + L R + QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Query: 231 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 280
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,612,914
Number of Sequences: 37866
Number of extensions: 1991596
Number of successful extensions: 24366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 697
Number of HSP's successfully gapped in prelim test: 1549
Number of HSP's that attempted gapping in prelim test: 12794
Number of HSP's gapped (non-prelim): 7798
length of query: 629
length of database: 18,247,518
effective HSP length: 108
effective length of query: 521
effective length of database: 14,157,990
effective search space: 7376312790
effective search space used: 7376312790
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.