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Search of human proteins with 47524177
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47524177 fibroblast growth factor receptor 4 isoform 2
precursor [Homo sapiens]
(762 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 1552 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 1479 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 1479 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 885 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 871 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 856 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 856 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 852 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 847 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 847 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 844 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 841 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 841 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 828 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 813 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 804 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 780 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 777 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 753 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 544 e-154
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 322 1e-87
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 320 3e-87
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 320 3e-87
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 310 3e-84
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 259 8e-69
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 259 8e-69
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 243 4e-64
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 242 1e-63
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 242 1e-63
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 241 2e-63
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 1552 bits (4018), Expect = 0.0
Identities = 762/762 (100%), Positives = 762/762 (100%)
Query: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
Sbjct: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
Query: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
Sbjct: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
Query: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
Sbjct: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHL 360
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHL
Sbjct: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHL 360
Query: 361 TCDSLTPAGRTKSPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLW 420
TCDSLTPAGRTKSPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLW
Sbjct: 361 TCDSLTPAGRTKSPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLW 420
Query: 421 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 480
EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE
Sbjct: 421 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 480
Query: 481 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 540
MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS
Sbjct: 481 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 540
Query: 541 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI 600
EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI
Sbjct: 541 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI 600
Query: 601 DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS 660
DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS
Sbjct: 601 DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS 660
Query: 661 LLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLT 720
LLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLT
Sbjct: 661 LLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLT 720
Query: 721 FGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT 762
FGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
Sbjct: 721 FGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT 762
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 1479 bits (3830), Expect = 0.0
Identities = 746/802 (93%), Positives = 746/802 (93%), Gaps = 40/802 (4%)
Query: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
Sbjct: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
Query: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
Sbjct: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
Query: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
Sbjct: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPG-----TG 355
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP T
Sbjct: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
Query: 356 RIPHL--------TCDSLTPA---------------GRTKSPTL------------QFSL 380
P SL A GR P QFSL
Sbjct: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
Query: 381 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 440
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
Sbjct: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
Query: 441 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 500
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
Sbjct: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
Query: 501 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 560
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
Sbjct: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
Query: 561 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 620
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
Sbjct: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
Query: 621 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 680
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
Sbjct: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
Query: 681 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 740
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
Sbjct: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
Query: 741 VFSHDPLPLGSSSFPFGSGVQT 762
VFSHDPLPLGSSSFPFGSGVQT
Sbjct: 781 VFSHDPLPLGSSSFPFGSGVQT 802
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 1479 bits (3830), Expect = 0.0
Identities = 746/802 (93%), Positives = 746/802 (93%), Gaps = 40/802 (4%)
Query: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
Sbjct: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
Query: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
Sbjct: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
Query: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
Sbjct: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPG-----TG 355
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP T
Sbjct: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
Query: 356 RIPHL--------TCDSLTPA---------------GRTKSPTL------------QFSL 380
P SL A GR P QFSL
Sbjct: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
Query: 381 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 440
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
Sbjct: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
Query: 441 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 500
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
Sbjct: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
Query: 501 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 560
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
Sbjct: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
Query: 561 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 620
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
Sbjct: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
Query: 621 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 680
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
Sbjct: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
Query: 681 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 740
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
Sbjct: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
Query: 741 VFSHDPLPLGSSSFPFGSGVQT 762
VFSHDPLPLGSSSFPFGSGVQT
Sbjct: 781 VFSHDPLPLGSSSFPFGSGVQT 802
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 885 bits (2288), Expect = 0.0
Identities = 482/792 (60%), Positives = 552/792 (69%), Gaps = 52/792 (6%)
Query: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
Query: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
Query: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
Query: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
Query: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
Query: 300 PYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----- 352
PYV VLKTA N++ E+EVL L NV+ EDAGEYTCLAGNSIG S+ SAWL VLP
Sbjct: 304 PYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEEL 363
Query: 353 ----------------GTGRIPHLTCDSLTPAGRTKSPTL------------------QF 378
G G + + R +SP Q
Sbjct: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 423
Query: 379 SLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCF 438
SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEGCF
Sbjct: 424 SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCF 483
Query: 439 GQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLG 498
GQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLLG
Sbjct: 484 GQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLG 543
Query: 499 VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVAR 558
CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVAR
Sbjct: 544 ACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVAR 603
Query: 559 GMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAP 618
GM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMAP
Sbjct: 604 GMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAP 663
Query: 619 EALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 678
EALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +L
Sbjct: 664 EALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDL 723
Query: 679 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTCS 736
Y +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+ S
Sbjct: 724 YMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSS 783
Query: 737 SSDSVFSHDPLP 748
DSVF+HD LP
Sbjct: 784 GDDSVFAHDLLP 795
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 871 bits (2250), Expect = 0.0
Identities = 459/785 (58%), Positives = 558/785 (71%), Gaps = 61/785 (7%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N+
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNT 319
Query: 313 S--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA 368
+ E+EVLY+RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP GR +T D L A
Sbjct: 320 TDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIA 379
Query: 369 ----------------------GRTKSPTLQ-------------------FSLESGSSGK 387
TK P S ES SS
Sbjct: 380 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 439
Query: 388 SSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAE 445
S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AE
Sbjct: 440 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 499
Query: 446 AFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP 505
A G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GP
Sbjct: 500 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 559
Query: 506 LYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES 565
LYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S
Sbjct: 560 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 619
Query: 566 RKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRV 625
+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRV
Sbjct: 620 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 679
Query: 626 YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMREC 685
YTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+C
Sbjct: 680 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 739
Query: 686 WHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFS 743
WHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS
Sbjct: 740 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 799
Query: 744 HDPLP 748
DP+P
Sbjct: 800 PDPMP 804
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 856 bits (2212), Expect = 0.0
Identities = 438/736 (59%), Positives = 534/736 (72%), Gaps = 52/736 (7%)
Query: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
Query: 124 S--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
S +DD+D S + ++ P APYWT P++MEKKLHAVPA TVKF+CP++G P P
Sbjct: 125 SEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNP 184
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
T+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y LD
Sbjct: 185 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 244
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
V+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D P
Sbjct: 245 VVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLP 304
Query: 301 YVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIP 358
YVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL P
Sbjct: 305 YVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
Query: 359 HLTCDSL-------------------------TPAGRTKSP------------------T 375
+ L +G KS
Sbjct: 365 AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ 424
Query: 376 LQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 435
+ S +S +S S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLGKPLGE
Sbjct: 425 VTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGE 484
Query: 436 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 495
GCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+HKNIIN
Sbjct: 485 GCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN 544
Query: 496 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 555
LLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LVSCAYQ
Sbjct: 545 LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQ 604
Query: 556 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 615
VARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGRLPVKW
Sbjct: 605 VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW 664
Query: 616 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 675
MAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRMD+P +C
Sbjct: 665 MAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT 724
Query: 676 PELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDA-SS 733
ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS D SS
Sbjct: 725 NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSS 784
Query: 734 TCSS-SDSVFSHDPLP 748
TCSS DSVFSH+PLP
Sbjct: 785 TCSSGEDSVFSHEPLP 800
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 155 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 214
Query: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 215 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 263
Query: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 264 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 310
Query: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 311 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 856 bits (2212), Expect = 0.0
Identities = 438/738 (59%), Positives = 535/738 (72%), Gaps = 54/738 (7%)
Query: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
Query: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
Query: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
Query: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
Query: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGR 356
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL
Sbjct: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
Query: 357 IPHLTCDSL-------------------------TPAGRTKSP----------------- 374
P + L +G KS
Sbjct: 365 RPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLR 424
Query: 375 -TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL 433
+ S +S +S S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLGKPL
Sbjct: 425 RQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPL 484
Query: 434 GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI 493
GEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+HKNI
Sbjct: 485 GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI 544
Query: 494 INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCA 553
INLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LVSCA
Sbjct: 545 INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCA 604
Query: 554 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 613
YQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGRLPV
Sbjct: 605 YQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV 664
Query: 614 KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH 673
KWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRMD+P +
Sbjct: 665 KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSN 724
Query: 674 CPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDA- 731
C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS D
Sbjct: 725 CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 784
Query: 732 SSTCSS-SDSVFSHDPLP 748
SSTCSS DSVFSH+PLP
Sbjct: 785 SSTCSSGEDSVFSHEPLP 802
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 157 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 216
Query: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 217 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 265
Query: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 266 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 312
Query: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 313 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 366
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 852 bits (2201), Expect = 0.0
Identities = 469/794 (59%), Positives = 541/794 (68%), Gaps = 54/794 (6%)
Query: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
Query: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
Query: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
Query: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
Query: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
Query: 300 PYVQVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP------ 352
PYV VLK+ S E +V L L NVS D GEY C A N IG++ ++ WL+V
Sbjct: 304 PYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEE 363
Query: 353 ------------------GTGRIPHLTCDSLTPAGRTKSPTL------------------ 376
G G + + R +SP
Sbjct: 364 ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKR 423
Query: 377 QFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEG 436
Q SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEG
Sbjct: 424 QVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEG 483
Query: 437 CFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINL 496
CFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINL
Sbjct: 484 CFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINL 543
Query: 497 LGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQV 556
LG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQV
Sbjct: 544 LGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQV 603
Query: 557 ARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM 616
ARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWM
Sbjct: 604 ARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWM 663
Query: 617 APEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPP 676
APEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C
Sbjct: 664 APEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTH 723
Query: 677 ELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SST 734
+LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+
Sbjct: 724 DLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS 783
Query: 735 CSSSDSVFSHDPLP 748
S DSVF+HD LP
Sbjct: 784 SSGDDSVFAHDLLP 797
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 847 bits (2188), Expect = 0.0
Identities = 453/786 (57%), Positives = 547/786 (69%), Gaps = 62/786 (7%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
Query: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP---GTGRIPHLTC--DSLTP 367
S EVL L NV+ DAGEY C N IG + QSAWLTVLP GR +T D L
Sbjct: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEI 379
Query: 368 A----------------------GRTKSPTLQ-------------------FSLESGSSG 386
A TK P S ES SS
Sbjct: 380 AIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM 439
Query: 387 KSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRA 444
S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV A
Sbjct: 440 NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMA 499
Query: 445 EAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG 504
EA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+G
Sbjct: 500 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 559
Query: 505 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564
PLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL
Sbjct: 560 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 619
Query: 565 SRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDR 624
S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDR
Sbjct: 620 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 679
Query: 625 VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRE 684
VYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+
Sbjct: 680 VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRD 739
Query: 685 CWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVF 742
CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVF
Sbjct: 740 CWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVF 799
Query: 743 SHDPLP 748
S DP+P
Sbjct: 800 SPDPMP 805
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 847 bits (2187), Expect = 0.0
Identities = 428/653 (65%), Positives = 504/653 (77%), Gaps = 47/653 (7%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA---------- 368
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP GR +T D L A
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
Query: 369 ------------GRTKSPTL-----------------QFSLESGSSGKSSSSLVR-GVRL 398
TK P Q S ES SS S++ LVR RL
Sbjct: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRL 334
Query: 399 SSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQA 457
SS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +A
Sbjct: 335 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 394
Query: 458 STVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGN 517
TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGN
Sbjct: 395 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 454
Query: 518 LREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARN 577
LRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAARN
Sbjct: 455 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 514
Query: 578 VLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGI 637
VLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+
Sbjct: 515 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 574
Query: 638 LLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFK 697
L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFK
Sbjct: 575 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 634
Query: 698 QLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 748
QLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 635 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 687
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
Query: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
Query: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
Query: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
Query: 237 YLLDVL 242
L VL
Sbjct: 240 AWLTVL 245
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 844 bits (2180), Expect = 0.0
Identities = 427/655 (65%), Positives = 503/655 (76%), Gaps = 49/655 (7%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA---------- 368
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP GR +T D L A
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
Query: 369 ------------GRTKSPTLQ-------------------FSLESGSSGKSSSSLVR-GV 396
TK P S ES SS S++ LVR
Sbjct: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
Query: 397 RLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPD 455
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P
Sbjct: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
Query: 456 QASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK 515
+A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+K
Sbjct: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
Query: 516 GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAA 575
GNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAA
Sbjct: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
Query: 576 RNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSF 635
RNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
Query: 636 GILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPT 695
G+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPT
Sbjct: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
Query: 696 FKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 748
FKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 635 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 689
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
Query: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
Query: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
Query: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
Query: 237 YLLDVL 242
L VL
Sbjct: 240 AWLTVL 245
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 841 bits (2173), Expect = 0.0
Identities = 432/700 (61%), Positives = 516/700 (73%), Gaps = 57/700 (8%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
Query: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
Query: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCL 334
QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCL
Sbjct: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCL 251
Query: 335 AGNSIGLSYQSAWLTVLPGTGRIPHLTCDSL-------------------------TPAG 369
AGNSIGLS+ SAWLTVL P + L +G
Sbjct: 252 AGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSG 311
Query: 370 RTKSP------------------TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVS 411
KS + S +S +S S LVR RLSSSG +LAG+
Sbjct: 312 TKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE 371
Query: 412 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 471
+LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++
Sbjct: 372 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE 431
Query: 472 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPD 531
KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG +
Sbjct: 432 KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 491
Query: 532 LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADF 591
+ + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADF
Sbjct: 492 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 551
Query: 592 GLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP 651
GLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYP
Sbjct: 552 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 611
Query: 652 GIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAV 710
G+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L
Sbjct: 612 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 671
Query: 711 SEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 748
++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 672 NQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 711
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 66 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 125
Query: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 126 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 174
Query: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 175 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
Query: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 222 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 275
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 841 bits (2173), Expect = 0.0
Identities = 432/702 (61%), Positives = 517/702 (73%), Gaps = 59/702 (8%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
Query: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
Query: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
Query: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYT 332
SD QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYT
Sbjct: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT 251
Query: 333 CLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSL-------------------------TP 367
CLAGNSIGLS+ SAWLTVL P + L
Sbjct: 252 CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMK 311
Query: 368 AGRTKSP------------------TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGL 409
+G KS + S +S +S S LVR RLSSSG +LAG+
Sbjct: 312 SGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 371
Query: 410 VSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA 469
+LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A
Sbjct: 372 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 431
Query: 470 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPG 529
++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG
Sbjct: 432 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 491
Query: 530 PDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 589
+ + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 492 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 551
Query: 590 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP 649
DFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSP
Sbjct: 552 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 611
Query: 650 YPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-L 708
YPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L
Sbjct: 612 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
Query: 709 AVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 748
++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 672 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 713
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 68 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 127
Query: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 128 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 176
Query: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 177 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
Query: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 224 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 277
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 828 bits (2139), Expect = 0.0
Identities = 418/674 (62%), Positives = 507/674 (75%), Gaps = 57/674 (8%)
Query: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
Query: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
Query: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
Query: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVS 324
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+RNV+
Sbjct: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
Query: 325 AEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA-------------- 368
EDAGEYTCLAGNSIG+S+ SAWLTVLP GR +T D L A
Sbjct: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 304
Query: 369 --------GRTKSPTLQ-------------------FSLESGSSGKSSSSLVR-GVRLSS 400
TK P S ES SS S++ LVR RLSS
Sbjct: 305 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 364
Query: 401 SGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAST 459
+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +A T
Sbjct: 365 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 424
Query: 460 VAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLR 519
VAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLR
Sbjct: 425 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 484
Query: 520 EFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVL 579
E+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAARNVL
Sbjct: 485 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 544
Query: 580 VTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILL 639
VTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L+
Sbjct: 545 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 604
Query: 640 WEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQL 699
WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQL
Sbjct: 605 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 664
Query: 700 VEALDKVLLAVSEE 713
VE LD++L + E
Sbjct: 665 VEDLDRILTLTTNE 678
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 813 bits (2099), Expect = 0.0
Identities = 430/749 (57%), Positives = 522/749 (69%), Gaps = 60/749 (8%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
Query: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP---GTGRIPHLTC--DSLTP 367
S EVL L NV+ DAGEY C N IG + QSAWLTVLP GR +T D L
Sbjct: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEI 379
Query: 368 A----------------------GRTKSPTLQ-------------------FSLESGSSG 386
A TK P S ES SS
Sbjct: 380 AIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM 439
Query: 387 KSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRA 444
S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV A
Sbjct: 440 NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMA 499
Query: 445 EAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG 504
EA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+G
Sbjct: 500 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 559
Query: 505 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564
PLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL
Sbjct: 560 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 619
Query: 565 SRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDR 624
S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDR
Sbjct: 620 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 679
Query: 625 VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRE 684
VYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+
Sbjct: 680 VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRD 739
Query: 685 CWHAAPSQRPTFKQLVEALDKVLLAVSEE 713
CWHA PSQRPTFKQLVE LD++L + E
Sbjct: 740 CWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 804 bits (2077), Expect = 0.0
Identities = 412/675 (61%), Positives = 496/675 (73%), Gaps = 58/675 (8%)
Query: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
Query: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
Query: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
Query: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAE 326
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INSS EVL L NV+
Sbjct: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
Query: 327 DAGEYTCLAGNSIGLSYQSAWLTVLP---GTGRIPHLTC--DSLTPA------------- 368
DAGEY C N IG + QSAWLTVLP GR +T D L A
Sbjct: 245 DAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMV 304
Query: 369 ---------GRTKSPTLQ-------------------FSLESGSSGKSSSSLVR-GVRLS 399
TK P S ES SS S++ LVR RLS
Sbjct: 305 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 364
Query: 400 SSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 458
S+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +A
Sbjct: 365 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 424
Query: 459 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 518
TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNL
Sbjct: 425 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 484
Query: 519 REFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNV 578
RE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAARNV
Sbjct: 485 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 544
Query: 579 LVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGIL 638
LVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L
Sbjct: 545 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 604
Query: 639 LWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQ 698
+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQ
Sbjct: 605 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 664
Query: 699 LVEALDKVLLAVSEE 713
LVE LD++L + E
Sbjct: 665 LVEDLDRILTLTTNE 679
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 780 bits (2013), Expect = 0.0
Identities = 433/751 (57%), Positives = 500/751 (66%), Gaps = 82/751 (10%)
Query: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
Query: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
Query: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
Query: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
Query: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQ
Sbjct: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQ--------------------- 282
Query: 300 PYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPH 359
P++Q LK ++N G+ +G
Sbjct: 283 PHIQWLKHVEVN------------------------GSKVG------------------- 299
Query: 360 LTCDSLTPAGRTKSPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPL 419
P G L+ SLES +S S++ LVR RLSS LA + L+LP DP
Sbjct: 300 -------PDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPK 352
Query: 420 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 479
WE R RL LGKPLGEGCFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVS
Sbjct: 353 WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVS 412
Query: 480 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 539
EME+MK+IG+HKNIINLLG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D +
Sbjct: 413 EMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKP 472
Query: 540 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 599
E L+F LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH+
Sbjct: 473 PEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN 532
Query: 600 IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF 659
+DYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF
Sbjct: 533 LDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF 592
Query: 660 SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLR 718
LL+EGHRMD+P +C +LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL
Sbjct: 593 KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLS 652
Query: 719 LTFGPYSPSGGDA-SSTCSSSDSVFSHDPLP 748
F YSP G D SS+ S DSVF+HD LP
Sbjct: 653 APFEQYSPGGQDTPSSSSSGDDSVFAHDLLP 683
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 777 bits (2006), Expect = 0.0
Identities = 412/738 (55%), Positives = 504/738 (68%), Gaps = 91/738 (12%)
Query: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
Query: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
Query: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
Query: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
Query: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGR 356
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL
Sbjct: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
Query: 357 IPHLTCDSL-------------------------TPAGRTKSP----------------- 374
P + L +G KS
Sbjct: 365 RPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLR 424
Query: 375 -TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL 433
+ S +S +S S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLGKPL
Sbjct: 425 RQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPL 484
Query: 434 GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI 493
GEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+HKNI
Sbjct: 485 GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI 544
Query: 494 INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCA 553
INLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LVSCA
Sbjct: 545 INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCA 604
Query: 554 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 613
YQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGRLPV
Sbjct: 605 YQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV 664
Query: 614 KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH 673
KWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEEL
Sbjct: 665 KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL--------------- 709
Query: 674 CPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDA- 731
FKQLVE LD+++ L ++EYLDL + YSPS D
Sbjct: 710 ----------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 747
Query: 732 SSTCSS-SDSVFSHDPLP 748
SSTCSS DSVFSH+PLP
Sbjct: 748 SSTCSSGEDSVFSHEPLP 765
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 157 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 216
Query: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 217 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 265
Query: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 266 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 312
Query: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 313 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 366
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 753 bits (1944), Expect = 0.0
Identities = 407/740 (55%), Positives = 500/740 (67%), Gaps = 87/740 (11%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQ P++Q +K + N
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQ---------------------PHIQWIKHVEKNG 298
Query: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTK 372
S+ G +P+L
Sbjct: 299 SKY-------------------------------------GPDGLPYLK----------- 310
Query: 373 SPTLQFSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLG 430
L+ S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LG
Sbjct: 311 --VLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 368
Query: 431 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 490
KPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+H
Sbjct: 369 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 428
Query: 491 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 550
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LV
Sbjct: 429 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 488
Query: 551 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 610
SC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGR
Sbjct: 489 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 548
Query: 611 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 670
LPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+
Sbjct: 549 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 608
Query: 671 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 729
P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 609 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYP 668
Query: 730 DASSTCSS-SDSVFSHDPLP 748
D S+CSS DSVFS DP+P
Sbjct: 669 DTRSSCSSGDDSVFSPDPMP 688
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 544 bits (1401), Expect = e-154
Identities = 325/680 (47%), Positives = 404/680 (59%), Gaps = 96/680 (14%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
L ++ P D G Y C V S + ++++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL-PG 353
+ + K + + S L + +V D G YTC+ N G + L V+ PG
Sbjct: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
Query: 354 TGRIPHLTCDSLTPA----------------------GRTKSPTLQ-------------- 377
+ + D L A TK P
Sbjct: 253 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 312
Query: 378 -----FSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLG 430
S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LG
Sbjct: 313 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 372
Query: 431 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 490
KPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+H
Sbjct: 373 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 432
Query: 491 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 550
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LV
Sbjct: 433 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 492
Query: 551 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 610
SC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGR
Sbjct: 493 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 552
Query: 611 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 670
LPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+
Sbjct: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612
Query: 671 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 729
P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYP 672
Query: 730 DASSTCSS-SDSVFSHDPLP 748
D S+CSS DSVFS DP+P
Sbjct: 673 DTRSSCSSGDDSVFSPDPMP 692
Score = 184 bits (467), Expect = 3e-46
Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 322 bits (824), Expect = 1e-87
Identities = 213/571 (37%), Positives = 296/571 (51%), Gaps = 111/571 (19%)
Query: 218 DRGTYTCLVENAVGSIRYNYL--LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275
D+G Y CL ++ R+ + L VLER P + L TT++ G +E+ C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLENQTTSI-GESIEVSCTASG 692
Query: 276 DAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
+ P I W K N + G VLK + N L +R V ED G YTC A
Sbjct: 693 NPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVRKEDEGLYTCQA 739
Query: 336 GNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTKSPTLQFSLESGSSGKSSSS---- 391
+ +G + A+ + G + L+ + G++ +
Sbjct: 740 CSVLGCAKVEAFFII-----------------EGAQEKTNLEIIILVGTAVIAMFFWLLL 782
Query: 392 --LVRGVRLSSSGPALLAGLVSL-----DLPLDP----------LWEFPRDRLVLGKPLG 434
++R V+ ++ G L G +S+ +LPLD WEFPRDRL LGKPLG
Sbjct: 783 VIILRTVKRANGGE-LKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLG 841
Query: 435 EGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNII 494
G FGQV+ A+AFG+D + TVAVKMLK+ A+ + L+SE++++ IG H N++
Sbjct: 842 RGAFGQVIEADAFGID--KTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 899
Query: 495 NLLGVCTQEG-PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGP---------- 543
NLLG CT+ G PL VIVE GNL +LR++R G R +G
Sbjct: 900 NLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDL 959
Query: 544 ----------------------------------------LSFPVLVSCAYQVARGMQYL 563
L+ L+ ++QVA+GM++L
Sbjct: 960 KRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFL 1019
Query: 564 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 623
SRKCIHRDLAARN+L++E NV+KI DFGLAR ++ Y + + RLP+KWMAPE +FD
Sbjct: 1020 ASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFD 1079
Query: 624 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF-SLLREGHRMDRPPHCPPELYGLM 682
RVYT QSDVWSFG+LLWEIF+LG SPYPG+ ++E F L+EG RM P + PE+Y M
Sbjct: 1080 RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTM 1139
Query: 683 RECWHAAPSQRPTFKQLVEALDKVLLAVSEE 713
+CWH PSQRPTF +LVE L +L A +++
Sbjct: 1140 LDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224
G +++ C A+GNP P I W KD + ++ GI L+ + +L + V D G YTC
Sbjct: 681 GESIEVSCTASGNPPPQIMWFKDNETLVEDS---GIVLKDGNRNLTIRRVRKEDEGLYTC 737
Query: 225 LVENAVG 231
+ +G
Sbjct: 738 QACSVLG 744
Score = 41.6 bits (96), Expect = 0.003
Identities = 42/199 (21%), Positives = 72/199 (36%), Gaps = 33/199 (16%)
Query: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
L I D G Y C A ++ +N T + +
Sbjct: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR-------------------------VHE 326
Query: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
P+ ME + A G V+ G P P I+W K+G + I +
Sbjct: 327 KPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAG 380
Query: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
H +ME V D G YT ++ N + + ++++ ++ P + ++ + + G+
Sbjct: 381 HVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGT 439
Query: 266 DVELLCKVYSDAQP-HIQW 283
L C VY+ P HI W
Sbjct: 440 TQTLTCTVYAIPPPHHIHW 458
Score = 39.3 bits (90), Expect = 0.014
Identities = 35/140 (25%), Positives = 57/140 (40%), Gaps = 22/140 (15%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ--AGLPANTTAVVGS 265
+L ++ V SD+G YTC + + + + + + V E+ P + +G+ + A VG
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 266 DVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSA 325
V + K P I+W K +G P ++ VL + VS
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
Query: 326 EDAGEYTCLAGNSIGLSYQS 345
D G YT + N I QS
Sbjct: 391 RDTGNYTVILTNPISKEKQS 410
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 320 bits (820), Expect = 3e-87
Identities = 178/338 (52%), Positives = 228/338 (67%), Gaps = 20/338 (5%)
Query: 396 VRLSSSG---PAL--LAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAF 447
V SSSG P+L + VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF
Sbjct: 685 VSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF 744
Query: 448 GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 507
+ +TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL
Sbjct: 745 HLKGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLL 801
Query: 508 VIVECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARG 559
+IVE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++G
Sbjct: 802 LIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG 861
Query: 560 MQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619
MQYL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E
Sbjct: 862 MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE 921
Query: 620 ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELY 679
+LFD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y
Sbjct: 922 SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMY 981
Query: 680 GLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 717
LM +CW P +RP F + + L+K+++ +YLDL
Sbjct: 982 RLMLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 320 bits (820), Expect = 3e-87
Identities = 178/338 (52%), Positives = 228/338 (67%), Gaps = 20/338 (5%)
Query: 396 VRLSSSG---PAL--LAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAF 447
V SSSG P+L + VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF
Sbjct: 685 VSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF 744
Query: 448 GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 507
+ +TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL
Sbjct: 745 HLKGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLL 801
Query: 508 VIVECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARG 559
+IVE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++G
Sbjct: 802 LIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG 861
Query: 560 MQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619
MQYL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E
Sbjct: 862 MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE 921
Query: 620 ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELY 679
+LFD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y
Sbjct: 922 SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMY 981
Query: 680 GLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 717
LM +CW P +RP F + + L+K+++ +YLDL
Sbjct: 982 RLMLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 310 bits (794), Expect = 3e-84
Identities = 213/563 (37%), Positives = 293/563 (52%), Gaps = 83/563 (14%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDV 267
+L + +V D GTY C N ++ R P L L +T A+ S
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI-SSST 678
Query: 268 ELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAED 327
L C +P I W K+ N G I L++ V+ ED
Sbjct: 679 TLDCHANGVPEPQITWFKN---NHKIQQEPGI----------ILGPGSSTLFIERVTEED 725
Query: 328 AGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTKSPTLQFSLESG--SS 385
G Y C A N G SA+LTV GT +L +LT + TL + L +
Sbjct: 726 EGVYHCKATNQKGSVESSAYLTV-QGTSDKSNLELITLTCT--CVAATLFWLLLTLFIRK 782
Query: 386 GKSSSSLVRGVRLSSSGPALLAGLVSLD-----LPLDPL-WEFPRDRLVLGKPLGEGCFG 439
K SSS ++ LS + V LD LP D WEF R+RL LGK LG G FG
Sbjct: 783 MKRSSSEIKTDYLSI---IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFG 839
Query: 440 QVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGV 499
+VV+A AFG+ + TVAVKMLK+ A+ + L++E++++ IG H N++NLLG
Sbjct: 840 KVVQASAFGIK--KSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGA 897
Query: 500 CTQEG-PLYVIVECAAKGNLREFLRARR--------------PPGPDLSP---------- 534
CT++G PL VIVE GNL +L+++R P + P
Sbjct: 898 CTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRL 957
Query: 535 DGPRSSEG---------------------------PLSFPVLVSCAYQVARGMQYLESRK 567
D SSE P++ L+S ++QVARGM++L SRK
Sbjct: 958 DSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRK 1017
Query: 568 CIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYT 627
CIHRDLAARN+L++E+NV+KI DFGLAR ++ Y + + RLP+KWMAPE++FD++Y+
Sbjct: 1018 CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYS 1077
Query: 628 HQSDVWSFGILLWEIFTLGGSPYPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECW 686
+SDVWS+G+LLWEIF+LGGSPYPG+ ++E F S LREG RM P + PE+Y +M +CW
Sbjct: 1078 TKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCW 1137
Query: 687 HAAPSQRPTFKQLVEALDKVLLA 709
H P +RP F +LVE L +L A
Sbjct: 1138 HRDPKERPRFAELVEKLGDLLQA 1160
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/141 (23%), Positives = 58/141 (41%), Gaps = 10/141 (7%)
Query: 150 THPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSL 209
T R ++ L V + + P+P + WLKDG ++ R + +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKS----ARYLTRGYSL 390
Query: 210 VMESVVPSDRGTYTCLV----ENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
+++ V D G YT L+ N ++ +++V + + + + P +GS
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 266 DVELLCKVYSDAQPHIQWLKH 286
L C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
Score = 43.1 bits (100), Expect = 0.001
Identities = 42/156 (26%), Positives = 58/156 (37%), Gaps = 28/156 (17%)
Query: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
L I + +D+G Y C AR + TG+ + + + RD Q+
Sbjct: 621 LTIMNVSLQDSGTYACRARN---------VYTGEEILQKKEI----TIRD--------QE 659
Query: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
APY H V ++ C A G P P I W K+ E GI L
Sbjct: 660 APYLLR----NLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPG 712
Query: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDV 241
+L +E V D G Y C N GS+ + L V
Sbjct: 713 SSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
Score = 38.5 bits (88), Expect = 0.024
Identities = 51/216 (23%), Positives = 78/216 (36%), Gaps = 61/216 (28%)
Query: 163 PAGNTVKFRCPAAGNPTPTIRW------------------------LKDGQAFHGENRIG 198
P G+ C A G P PTI+W + D + G NRI
Sbjct: 445 PLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG-NRIE 503
Query: 199 GIRLRH---QHWSLVMESVVPSDR---GTYTCLVENAVGSIRYN---YLLDV-------L 242
I R + + + ++V +D G Y C+ N VG++ N Y+ DV L
Sbjct: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
Query: 243 ERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYV 302
E+ P G D++L C V + W+ +N + +
Sbjct: 564 EKMP---------------TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS----I 604
Query: 303 QVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGN 337
K A + + L + NVS +D+G Y C A N
Sbjct: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
Score = 30.4 bits (67), Expect = 6.4
Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 15/126 (11%)
Query: 209 LVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVE 268
L ++ + D+G YTC V + N + + +++ + T
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKA-FITVKHRKQQVLETVAGKRSYR 354
Query: 269 LLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDA 328
L KV + P + WLK DG P + K+A + ++ +++V+ EDA
Sbjct: 355 LSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYSLI-IKDVTEEDA 400
Query: 329 GEYTCL 334
G YT L
Sbjct: 401 GNYTIL 406
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 259 bits (661), Expect = 8e-69
Identities = 124/210 (59%), Positives = 155/210 (73%), Gaps = 9/210 (4%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
Query: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
Query: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLK 306
QPHIQWLKHI +NGS G D PYVQ+LK
Sbjct: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 259 bits (661), Expect = 8e-69
Identities = 124/212 (58%), Positives = 156/212 (73%), Gaps = 11/212 (5%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
Query: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
Query: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
Query: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLK 306
SD QPHIQWLKHI +NGS G D PYVQ+LK
Sbjct: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 243 bits (621), Expect = 4e-64
Identities = 138/301 (45%), Positives = 187/301 (62%), Gaps = 10/301 (3%)
Query: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492
+GEG FGQV+RA + A+KMLK+ AS+ D D E+EV+ +G H N
Sbjct: 845 IGEGNFGQVIRAMI-----KKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
Query: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 552
IINLLG C G LY+ +E A GNL +FLR R D + + LS L+
Sbjct: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
Query: 553 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 612
A A GMQYL ++ IHRDLAARNVLV E+ KIADFGL+RG + Y K + GRLP
Sbjct: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLP 1016
Query: 613 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 672
V+WMA E+L VYT +SDVWSFG+LLWEI +LGG+PY G+ EL+ L +G+RM++P
Sbjct: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
Query: 673 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDAS 732
+C E+Y LMR+CW P +RP F Q+ L ++L A + Y+++ L F ++ +G DA+
Sbjct: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA-RKAYVNMSL-FENFTYAGIDAT 1134
Query: 733 S 733
+
Sbjct: 1135 A 1135
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 242 bits (617), Expect = 1e-63
Identities = 150/401 (37%), Positives = 208/401 (51%), Gaps = 71/401 (17%)
Query: 414 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 473
LP D WEFPR+RL GK LG G FG+VV A A+G+ + D A TVAVKMLK +A +
Sbjct: 572 LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGL--IKSDAAMTVAVKMLKPSAHLTE 629
Query: 474 LADLVSE----------MEVMKLIGR---------------HKNIINLLG------VCTQ 502
L+SE M ++ L+G + +++N L +C++
Sbjct: 630 REALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSK 689
Query: 503 -----EGPLY------------------------VIVECAAKGNLREFLRARRPPGPDLS 533
E LY V K + R +R D++
Sbjct: 690 QEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVT 749
Query: 534 PDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGL 593
P E L L+S +YQVA+GM +L S+ CIHRDLAARN+L+T + KI DFGL
Sbjct: 750 PAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 809
Query: 594 ARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI 653
AR + + Y N RLPVKWMAPE++F+ VYT +SDVWS+GI LWE+F+LG SPYPG+
Sbjct: 810 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 869
Query: 654 PVE-ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 712
PV+ + + +++EG RM P H P E+Y +M+ CW A P +RPTFKQ+V+ ++K + +
Sbjct: 870 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 929
Query: 713 EYLDLRLTFGP--------YSPSGGDASSTCSSSDSVFSHD 745
P +S ST SSS + HD
Sbjct: 930 HIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHD 970
Score = 34.7 bits (78), Expect = 0.34
Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 13/134 (9%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVV--GS 265
+L + S +D G + C N GS L+V+++ + NTT V G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 266 DVELLCKVYSDAQP-HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVS 324
+V+L+ + + +P H QW + +F Y + + N V L+L +
Sbjct: 330 NVDLIVEYEAFPKPEHQQW----IYMNRTFTDKWEDYPK--SENESNIRYVSELHLTRLK 383
Query: 325 AEDAGEYTCLAGNS 338
+ G YT L NS
Sbjct: 384 GTEGGTYTFLVSNS 397
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 242 bits (617), Expect = 1e-63
Identities = 150/401 (37%), Positives = 208/401 (51%), Gaps = 71/401 (17%)
Query: 414 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 473
LP D WEFPR+RL GK LG G FG+VV A A+G+ + D A TVAVKMLK +A +
Sbjct: 576 LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGL--IKSDAAMTVAVKMLKPSAHLTE 633
Query: 474 LADLVSE----------MEVMKLIGR---------------HKNIINLLG------VCTQ 502
L+SE M ++ L+G + +++N L +C++
Sbjct: 634 REALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSK 693
Query: 503 -----EGPLY------------------------VIVECAAKGNLREFLRARRPPGPDLS 533
E LY V K + R +R D++
Sbjct: 694 QEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVT 753
Query: 534 PDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGL 593
P E L L+S +YQVA+GM +L S+ CIHRDLAARN+L+T + KI DFGL
Sbjct: 754 PAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 813
Query: 594 ARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI 653
AR + + Y N RLPVKWMAPE++F+ VYT +SDVWS+GI LWE+F+LG SPYPG+
Sbjct: 814 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 873
Query: 654 PVE-ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 712
PV+ + + +++EG RM P H P E+Y +M+ CW A P +RPTFKQ+V+ ++K + +
Sbjct: 874 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 933
Query: 713 EYLDLRLTFGP--------YSPSGGDASSTCSSSDSVFSHD 745
P +S ST SSS + HD
Sbjct: 934 HIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHD 974
Score = 34.7 bits (78), Expect = 0.34
Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 13/134 (9%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVV--GS 265
+L + S +D G + C N GS L+V+++ + NTT V G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 266 DVELLCKVYSDAQP-HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVS 324
+V+L+ + + +P H QW + +F Y + + N V L+L +
Sbjct: 330 NVDLIVEYEAFPKPEHQQW----IYMNRTFTDKWEDYPK--SENESNIRYVSELHLTRLK 383
Query: 325 AEDAGEYTCLAGNS 338
+ G YT L NS
Sbjct: 384 GTEGGTYTFLVSNS 397
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 241 bits (615), Expect = 2e-63
Identities = 131/275 (47%), Positives = 177/275 (64%), Gaps = 8/275 (2%)
Query: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492
+GEG FGQV++A D R D A+K +K+ AS D D E+EV+ +G H N
Sbjct: 830 IGEGNFGQVLKAR-IKKDGLRMD----AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 552
IINLLG C G LY+ +E A GNL +FLR R D + S+ LS L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 553 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 612
A VARGM YL ++ IHRDLAARN+LV E+ V KIADFGL+RG + Y K + GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
Query: 613 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 672
V+WMA E+L VYT SDVWS+G+LLWEI +LGG+PY G+ EL+ L +G+R+++P
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 673 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707
+C E+Y LMR+CW P +RP+F Q++ +L+++L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,632,217
Number of Sequences: 37866
Number of extensions: 1721746
Number of successful extensions: 11390
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 710
Number of HSP's successfully gapped in prelim test: 323
Number of HSP's that attempted gapping in prelim test: 5171
Number of HSP's gapped (non-prelim): 3366
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.