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Search of human proteins with 47524175
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47524175 fibroblast growth factor receptor 4 isoform 1
precursor [Homo sapiens]
(802 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 1628 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 1628 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 1479 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 922 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 889 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 885 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 883 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 883 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 872 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 868 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 868 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 867 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 862 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 847 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 837 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 829 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 803 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 569 e-162
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 549 e-156
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 548 e-155
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 321 1e-87
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 321 1e-87
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 319 6e-87
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 304 2e-82
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 259 9e-69
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 259 9e-69
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 249 7e-66
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 242 1e-63
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 242 1e-63
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 241 2e-63
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 1628 bits (4216), Expect = 0.0
Identities = 802/802 (100%), Positives = 802/802 (100%)
Query: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
Sbjct: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
Query: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
Sbjct: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
Query: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
Sbjct: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
Sbjct: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
Query: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
Sbjct: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
Query: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
Sbjct: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
Query: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
Sbjct: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
Query: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
Sbjct: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
Query: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
Sbjct: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
Query: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
Sbjct: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
Query: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
Sbjct: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
Query: 781 VFSHDPLPLGSSSFPFGSGVQT 802
VFSHDPLPLGSSSFPFGSGVQT
Sbjct: 781 VFSHDPLPLGSSSFPFGSGVQT 802
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 1628 bits (4216), Expect = 0.0
Identities = 802/802 (100%), Positives = 802/802 (100%)
Query: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
Sbjct: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
Query: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
Sbjct: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
Query: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
Sbjct: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
Sbjct: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
Query: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
Sbjct: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
Query: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
Sbjct: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
Query: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
Sbjct: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
Query: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
Sbjct: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
Query: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
Sbjct: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
Query: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
Sbjct: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
Query: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
Sbjct: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
Query: 781 VFSHDPLPLGSSSFPFGSGVQT 802
VFSHDPLPLGSSSFPFGSGVQT
Sbjct: 781 VFSHDPLPLGSSSFPFGSGVQT 802
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 1479 bits (3830), Expect = 0.0
Identities = 746/802 (93%), Positives = 746/802 (93%), Gaps = 40/802 (4%)
Query: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
Sbjct: 1 MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA 60
Query: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
Sbjct: 61 ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS 120
Query: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
Sbjct: 121 LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA 360
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP T
Sbjct: 301 YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPG-----TG 355
Query: 361 AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL 420
P SL A GR P QFSL
Sbjct: 356 RIPHL--------TCDSLTPA---------------GRTKSPTL------------QFSL 380
Query: 421 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
Sbjct: 381 ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 440
Query: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
Sbjct: 441 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 500
Query: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
Sbjct: 501 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 560
Query: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
Sbjct: 561 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 620
Query: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
Sbjct: 621 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 680
Query: 721 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 780
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
Sbjct: 681 LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS 740
Query: 781 VFSHDPLPLGSSSFPFGSGVQT 802
VFSHDPLPLGSSSFPFGSGVQT
Sbjct: 741 VFSHDPLPLGSSSFPFGSGVQT 762
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 922 bits (2383), Expect = 0.0
Identities = 495/793 (62%), Positives = 572/793 (72%), Gaps = 14/793 (1%)
Query: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
Query: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
Query: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
Query: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
Query: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
Query: 300 PYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPT 357
PYV VLKTA N++ E+EVL L NV+ EDAGEYTCLAGNSIG S+ SAWL VLP E+
Sbjct: 304 PYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEEL 363
Query: 358 WTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQ 417
A + Y I+ Y G +++ L R ++ + P TV K+SRFPL RQ
Sbjct: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKISRFPLKRQ 422
Query: 418 FSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGC 477
SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEGC
Sbjct: 423 VSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGC 482
Query: 478 FGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLL 537
FGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLL
Sbjct: 483 FGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLL 542
Query: 538 GVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVA 597
G CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVA
Sbjct: 543 GACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVA 602
Query: 598 RGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMA 657
RGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMA
Sbjct: 603 RGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMA 662
Query: 658 PEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPE 717
PEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +
Sbjct: 663 PEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHD 722
Query: 718 LYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTC 775
LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+
Sbjct: 723 LYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 782
Query: 776 SSSDSVFSHDPLP 788
S DSVF+HD LP
Sbjct: 783 SGDDSVFAHDLLP 795
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 889 bits (2298), Expect = 0.0
Identities = 468/790 (59%), Positives = 579/790 (73%), Gaps = 31/790 (3%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N+
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNT 319
Query: 313 S--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEAR 366
+ E+EVLY+RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+
Sbjct: 320 TDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD-- 374
Query: 367 YTDIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLES 422
Y +I +Y G +A +++ L R + + PA + R PL RQ S ES
Sbjct: 375 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 434
Query: 423 GSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ 480
SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQ
Sbjct: 435 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQ 494
Query: 481 VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
VV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG C
Sbjct: 495 VVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGAC 554
Query: 541 TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM 600
TQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM
Sbjct: 555 TQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGM 614
Query: 601 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEA
Sbjct: 615 EYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEA 674
Query: 661 LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG 720
LFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY
Sbjct: 675 LFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYM 734
Query: 721 LMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-S 778
+MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS
Sbjct: 735 MMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGD 794
Query: 779 DSVFSHDPLP 788
DSVFS DP+P
Sbjct: 795 DSVFSPDPMP 804
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 885 bits (2287), Expect = 0.0
Identities = 484/795 (60%), Positives = 561/795 (70%), Gaps = 16/795 (2%)
Query: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
Query: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
Query: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
Query: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
Query: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
Query: 300 PYVQVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL-PEEDPT 357
PYV VLK+ S E +V L L NVS D GEY C A N IG++ ++ WL+V P
Sbjct: 304 PYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEE 363
Query: 358 WTAAAPEAR--YTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLA 415
A EA Y I+ Y G +++ L R ++ + P TV K+SRFPL
Sbjct: 364 ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKISRFPLK 422
Query: 416 RQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 475
RQ SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGE
Sbjct: 423 RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE 482
Query: 476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 535
GCFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIIN
Sbjct: 483 GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN 542
Query: 536 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 595
LLG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQ
Sbjct: 543 LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ 602
Query: 596 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 655
VARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKW
Sbjct: 603 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW 662
Query: 656 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 715
MAPEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C
Sbjct: 663 MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT 722
Query: 716 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SS 773
+LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS
Sbjct: 723 HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS 782
Query: 774 TCSSSDSVFSHDPLP 788
+ S DSVF+HD LP
Sbjct: 783 SSSGDDSVFAHDLLP 797
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 883 bits (2281), Expect = 0.0
Identities = 451/741 (60%), Positives = 559/741 (75%), Gaps = 22/741 (2%)
Query: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
Query: 124 S--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
S +DD+D S + ++ P APYWT P++MEKKLHAVPA TVKF+CP++G P P
Sbjct: 125 SEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNP 184
Query: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
T+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y LD
Sbjct: 185 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 244
Query: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
V+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D P
Sbjct: 245 VVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLP 304
Query: 301 YVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EEDP 356
YVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE P
Sbjct: 305 YVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
Query: 357 TWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR-F 412
A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 365 ---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAKSI 419
Query: 413 PLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLG 470
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLG
Sbjct: 420 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 479
Query: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
KPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+H
Sbjct: 480 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 539
Query: 531 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 590
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LV
Sbjct: 540 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 599
Query: 591 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 650
SCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGR
Sbjct: 600 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 659
Query: 651 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 710
LPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRMD+
Sbjct: 660 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 719
Query: 711 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 769
P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 720 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 779
Query: 770 DA-SSTCSS-SDSVFSHDPLP 788
D SSTCSS DSVFSH+PLP
Sbjct: 780 DTRSSTCSSGEDSVFSHEPLP 800
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 883 bits (2281), Expect = 0.0
Identities = 451/743 (60%), Positives = 560/743 (75%), Gaps = 24/743 (3%)
Query: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
Query: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
Query: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
Query: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
Query: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EE 354
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE
Sbjct: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
Query: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR 411
P A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 365 RP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAK 419
Query: 412 -FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLV 468
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLV
Sbjct: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
Query: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
LGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG
Sbjct: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
Query: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS
Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+N
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
Query: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
GRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRM
Sbjct: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 719
Query: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
D+P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 720 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 779
Query: 768 GGDA-SSTCSS-SDSVFSHDPLP 788
D SSTCSS DSVFSH+PLP
Sbjct: 780 FPDTRSSTCSSGEDSVFSHEPLP 802
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 872 bits (2252), Expect = 0.0
Identities = 460/788 (58%), Positives = 566/788 (71%), Gaps = 26/788 (3%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
Query: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYT 368
S EVL L NV+ DAGEY C N IG + QSAWLTVLP++ A+P+ Y
Sbjct: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YL 377
Query: 369 DIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGS 424
+I +Y G +A +++ L R + + PA + R PL RQ S ES S
Sbjct: 378 EIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSS 437
Query: 425 SGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVV 482
S S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV
Sbjct: 438 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 497
Query: 483 RAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQ 542
AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ
Sbjct: 498 MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 557
Query: 543 EGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 602
+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+Y
Sbjct: 558 DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 617
Query: 603 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALF 662
L S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALF
Sbjct: 618 LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 677
Query: 663 DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLM 722
DRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +M
Sbjct: 678 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMM 737
Query: 723 RECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDS 780
R+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DS
Sbjct: 738 RDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDS 797
Query: 781 VFSHDPLP 788
VFS DP+P
Sbjct: 798 VFSPDPMP 805
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 868 bits (2242), Expect = 0.0
Identities = 445/705 (63%), Positives = 541/705 (76%), Gaps = 27/705 (3%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
Query: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
Query: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCL 334
QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCL
Sbjct: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCL 251
Query: 335 AGNSIGLSYQSAWLTVLP--EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR- 391
AGNSIGLS+ SAWLTVL EE P A Y +II+Y +G+ ++ ++ +Y+
Sbjct: 252 AGNSIGLSHHSAWLTVLEALEERP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKM 308
Query: 392 --GQALHGRHPRPPATVQKLSR-FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALL 446
G H + V KL++ PL RQ ++ + SS +S LVR RLSSSG +L
Sbjct: 309 KSGTKKSDFHSQ--MAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPML 366
Query: 447 AGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK 506
AG+ +LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK
Sbjct: 367 AGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 426
Query: 507 DNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR 566
+A++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARR
Sbjct: 427 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 486
Query: 567 PPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVM 626
PPG + + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVM
Sbjct: 487 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 546
Query: 627 KIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLG 686
KIADFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLG
Sbjct: 547 KIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG 606
Query: 687 GSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 746
GSPYPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++
Sbjct: 607 GSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 666
Query: 747 L-LAVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 788
+ L ++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 667 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 711
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 868 bits (2242), Expect = 0.0
Identities = 445/707 (62%), Positives = 542/707 (76%), Gaps = 29/707 (4%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
Query: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
Query: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
Query: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYT 332
SD QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYT
Sbjct: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT 251
Query: 333 CLAGNSIGLSYQSAWLTVLP--EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLY 390
CLAGNSIGLS+ SAWLTVL EE P A Y +II+Y +G+ ++ ++ +Y
Sbjct: 252 CLAGNSIGLSHHSAWLTVLEALEERP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVY 308
Query: 391 R---GQALHGRHPRPPATVQKLSR-FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPA 444
+ G H + V KL++ PL RQ ++ + SS +S LVR RLSSSG
Sbjct: 309 KMKSGTKKSDFHSQ--MAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTP 366
Query: 445 LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKM 504
+LAG+ +LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKM
Sbjct: 367 MLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKM 426
Query: 505 LKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRA 564
LK +A++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+A
Sbjct: 427 LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 486
Query: 565 RRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN 624
RRPPG + + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDN
Sbjct: 487 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 546
Query: 625 VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT 684
VMKIADFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFT
Sbjct: 547 VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 606
Query: 685 LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
LGGSPYPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD
Sbjct: 607 LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 666
Query: 745 KVL-LAVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 788
+++ L ++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 667 RIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 713
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 867 bits (2241), Expect = 0.0
Identities = 436/658 (66%), Positives = 524/658 (79%), Gaps = 17/658 (2%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASG 376
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIG 269
Query: 377 SLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVR 434
+A +++ L R + + PA + R PL RQ S ES SS S++ LVR
Sbjct: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVR 329
Query: 435 -GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D
Sbjct: 330 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 389
Query: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
+P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE
Sbjct: 390 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 449
Query: 553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 612
A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRD
Sbjct: 450 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 509
Query: 613 LAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 672
LAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 510 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 569
Query: 673 WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
WSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQ
Sbjct: 570 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 629
Query: 733 RPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 788
RPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 630 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 687
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
Query: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
Query: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
Query: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
Query: 237 YLLDVL 242
L VL
Sbjct: 240 AWLTVL 245
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 862 bits (2228), Expect = 0.0
Identities = 436/660 (66%), Positives = 524/660 (79%), Gaps = 19/660 (2%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASG 376
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIG 269
Query: 377 SLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSL 432
+A +++ L R + + PA + R PL RQ S ES SS S++ L
Sbjct: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 329
Query: 433 VR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMD 490
VR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D
Sbjct: 330 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 389
Query: 491 PARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIV 550
+P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIV
Sbjct: 390 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 449
Query: 551 ECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIH 610
E A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIH
Sbjct: 450 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 509
Query: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670
RDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQS
Sbjct: 510 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 569
Query: 671 DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAP 730
DVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA P
Sbjct: 570 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 629
Query: 731 SQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 788
SQRPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 630 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 689
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
Query: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
Query: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
Query: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
Query: 237 YLLDVL 242
L VL
Sbjct: 240 AWLTVL 245
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 847 bits (2187), Expect = 0.0
Identities = 427/679 (62%), Positives = 528/679 (77%), Gaps = 27/679 (3%)
Query: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
Query: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
Query: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
Query: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVS 324
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+RNV+
Sbjct: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
Query: 325 AEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASGSLAL 380
EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G +
Sbjct: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIGVFLI 299
Query: 381 AVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSLVR-G 435
A +++ L R + + PA + R PL RQ S ES SS S++ LVR
Sbjct: 300 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 359
Query: 436 VRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARP 494
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P
Sbjct: 360 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 419
Query: 495 DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAA 554
+A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+
Sbjct: 420 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 479
Query: 555 KGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLA 614
KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLA
Sbjct: 480 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 539
Query: 615 ARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWS 674
ARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 540 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 599
Query: 675 FGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP 734
FG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRP
Sbjct: 600 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 659
Query: 735 TFKQLVEALDKVLLAVSEE 753
TFKQLVE LD++L + E
Sbjct: 660 TFKQLVEDLDRILTLTTNE 678
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 837 bits (2163), Expect = 0.0
Identities = 437/751 (58%), Positives = 541/751 (72%), Gaps = 24/751 (3%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
Query: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYT 368
S EVL L NV+ DAGEY C N IG + QSAWLTVLP++ A+P+ Y
Sbjct: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YL 377
Query: 369 DIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGS 424
+I +Y G +A +++ L R + + PA + R PL RQ S ES S
Sbjct: 378 EIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSS 437
Query: 425 SGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVV 482
S S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV
Sbjct: 438 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 497
Query: 483 RAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQ 542
AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ
Sbjct: 498 MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 557
Query: 543 EGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 602
+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+Y
Sbjct: 558 DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 617
Query: 603 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALF 662
L S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALF
Sbjct: 618 LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 677
Query: 663 DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLM 722
DRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +M
Sbjct: 678 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMM 737
Query: 723 RECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
R+CWHA PSQRPTFKQLVE LD++L + E
Sbjct: 738 RDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 829 bits (2141), Expect = 0.0
Identities = 419/677 (61%), Positives = 515/677 (76%), Gaps = 22/677 (3%)
Query: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
Query: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
Query: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
Query: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAE 326
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INSS EVL L NV+
Sbjct: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
Query: 327 DAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYTDIILYASGSLALAV 382
DAGEY C N IG + QSAWLTVLP++ A+P+ Y +I +Y G +A
Sbjct: 245 DAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YLEIAIYCIGVFLIAC 302
Query: 383 LLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSLVR-GVR 437
+++ L R + + PA + R PL RQ S ES SS S++ LVR R
Sbjct: 303 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTR 362
Query: 438 LSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQ 496
LSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +
Sbjct: 363 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 422
Query: 497 ASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 556
A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KG
Sbjct: 423 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 482
Query: 557 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 616
NLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAAR
Sbjct: 483 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 542
Query: 617 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 676
NVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG
Sbjct: 543 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 602
Query: 677 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 736
+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTF
Sbjct: 603 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 662
Query: 737 KQLVEALDKVLLAVSEE 753
KQLVE LD++L + E
Sbjct: 663 KQLVEDLDRILTLTTNE 679
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 803 bits (2075), Expect = 0.0
Identities = 425/743 (57%), Positives = 529/743 (71%), Gaps = 61/743 (8%)
Query: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
Query: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
Query: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
Query: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
Query: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EE 354
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE
Sbjct: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
Query: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR 411
P A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 365 RP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAK 419
Query: 412 -FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLV 468
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLV
Sbjct: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
Query: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
LGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG
Sbjct: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
Query: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS
Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+N
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
Query: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
GRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEEL
Sbjct: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
Query: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
FKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
Query: 768 GGDA-SSTCSS-SDSVFSHDPLP 788
D SSTCSS DSVFSH+PLP
Sbjct: 743 FPDTRSSTCSSGEDSVFSHEPLP 765
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 569 bits (1467), Expect = e-162
Identities = 333/682 (48%), Positives = 421/682 (61%), Gaps = 60/682 (8%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
L ++ P D G Y C V S + ++++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
+ + K + + S L + +V D G YTC+ N G + L V+
Sbjct: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPG 252
Query: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRF 412
A+P+ Y +I +Y G +A +++ L R + + PA + R
Sbjct: 253 REKEITASPD--YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 310
Query: 413 PLARQF--SLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLV 468
PL RQ S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L
Sbjct: 311 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 370
Query: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
LGKPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG
Sbjct: 371 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 430
Query: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F
Sbjct: 431 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
Query: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+N
Sbjct: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 550
Query: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
GRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRM
Sbjct: 551 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 610
Query: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
D+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 611 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670
Query: 768 GGDASSTCSS-SDSVFSHDPLP 788
D S+CSS DSVFS DP+P
Sbjct: 671 YPDTRSSCSSGDDSVFSPDPMP 692
Score = 184 bits (467), Expect = 3e-46
Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 12/230 (5%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVL 242
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 549 bits (1414), Expect = e-156
Identities = 335/658 (50%), Positives = 396/658 (60%), Gaps = 60/658 (9%)
Query: 164 AGNTVKFRCPA-AGNPTPTIRWLKDGQAFHGENRI--GGIRLRHQHWSLVMESVVPSDRG 220
+G+ V+ CP G P W+KDG R+ G RL+ + S D G
Sbjct: 53 SGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNAS-------HEDSG 105
Query: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV------------------ 262
Y+C + + ++ + V + A T V
Sbjct: 106 AYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLL 164
Query: 263 ---VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLY 319
+ V C + P I WLK NG F G + +K S L
Sbjct: 165 AVPAANTVRFRCPAAGNPTPSISWLK----NGREFR--GEHRIGGIKLRHQQWS----LV 214
Query: 320 LRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEED--PTWTAAAPEARY----TDIILY 373
+ +V D G YTC+ N G Q+ L VL P A P + +D+ +
Sbjct: 215 MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFH 274
Query: 374 ASG-SLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432
S A + L + + G P TV K+S LES +S S++ L
Sbjct: 275 CKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS---------LESNASMSSNTPL 325
Query: 433 VRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
VR RLSS LA + L+LP DP WE R RL LGKPLGEGCFGQVV AEA G+D
Sbjct: 326 VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKD 385
Query: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLLG CTQ GPLYV+VE
Sbjct: 386 RAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEY 445
Query: 553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 612
AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVARGM+YL S+KCIHRD
Sbjct: 446 AAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD 505
Query: 613 LAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 672
LAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 506 LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 565
Query: 673 WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
WSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +LY +MRECWHAAPSQ
Sbjct: 566 WSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQ 625
Query: 733 RPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTCSSSDSVFSHDPLP 788
RPTFKQLVE LD+VL S +EYLDL F YSP G D SS+ S DSVF+HD LP
Sbjct: 626 RPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLP 683
Score = 310 bits (794), Expect = 3e-84
Identities = 177/340 (52%), Positives = 214/340 (62%), Gaps = 10/340 (2%)
Query: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
Query: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
Query: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
Query: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
Query: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
Query: 300 PYVQVLKTA-DINSSEVEVLYLRNVSAEDAGEYTCLAGNS 338
PYV VLK + + N+S L ++ +GE LA S
Sbjct: 304 PYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVS 343
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 548 bits (1411), Expect = e-155
Identities = 327/685 (47%), Positives = 413/685 (60%), Gaps = 70/685 (10%)
Query: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
L ++ P D G Y C V S + ++++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
+ + K + + S L + +V D G YTC+ N G + L V+
Sbjct: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERS 252
Query: 355 D--PTWTAAAPEARYTDI-----ILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQ 407
P A P T + + S A + + + + + +G P V
Sbjct: 253 PHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL 312
Query: 408 KLSRFPLARQFSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRD 465
K+S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD
Sbjct: 313 KVSA---------ESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 363
Query: 466 RLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMK 525
+L LGKPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK
Sbjct: 364 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 423
Query: 526 LIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLS 585
+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++
Sbjct: 424 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 483
Query: 586 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 645
F LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKK
Sbjct: 484 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 543
Query: 646 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 705
T+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EG
Sbjct: 544 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 603
Query: 706 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPY 764
HRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL Y
Sbjct: 604 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQY 663
Query: 765 SPSGGDASSTCSS-SDSVFSHDPLP 788
SPS D S+CSS DSVFS DP+P
Sbjct: 664 SPSYPDTRSSCSSGDDSVFSPDPMP 688
Score = 291 bits (746), Expect = 1e-78
Identities = 150/303 (49%), Positives = 200/303 (66%), Gaps = 12/303 (3%)
Query: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
Query: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
Query: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
Query: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
Query: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + +S
Sbjct: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESS 319
Query: 313 SEV 315
S +
Sbjct: 320 SSM 322
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 321 bits (823), Expect = 1e-87
Identities = 187/396 (47%), Positives = 248/396 (62%), Gaps = 31/396 (7%)
Query: 378 LALAVLL--LLAGLYRGQALHGRHP---RPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432
+A AVL +++ L +H H +PP + +++ A+ F + SSG SL
Sbjct: 638 IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSL 697
Query: 433 VRGVRLSSSGPALLAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM 489
+ VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF +
Sbjct: 698 DS-----------MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 746
Query: 490 DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 549
+TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL +I
Sbjct: 747 KGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLI 803
Query: 550 VECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARGMQ 601
VE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++GMQ
Sbjct: 804 VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQ 863
Query: 602 YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661
YL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E+L
Sbjct: 864 YLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923
Query: 662 FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721
FD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y L
Sbjct: 924 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983
Query: 722 MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757
M +CW P +RP F + + L+K+++ +YLDL
Sbjct: 984 MLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 321 bits (823), Expect = 1e-87
Identities = 187/396 (47%), Positives = 248/396 (62%), Gaps = 31/396 (7%)
Query: 378 LALAVLL--LLAGLYRGQALHGRHP---RPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432
+A AVL +++ L +H H +PP + +++ A+ F + SSG SL
Sbjct: 638 IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSL 697
Query: 433 VRGVRLSSSGPALLAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM 489
+ VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF +
Sbjct: 698 DS-----------MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 746
Query: 490 DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 549
+TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL +I
Sbjct: 747 KGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLI 803
Query: 550 VECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARGMQ 601
VE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++GMQ
Sbjct: 804 VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQ 863
Query: 602 YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661
YL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E+L
Sbjct: 864 YLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923
Query: 662 FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721
FD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y L
Sbjct: 924 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983
Query: 722 MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757
M +CW P +RP F + + L+K+++ +YLDL
Sbjct: 984 MLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 319 bits (818), Expect = 6e-87
Identities = 219/605 (36%), Positives = 301/605 (49%), Gaps = 139/605 (22%)
Query: 218 DRGTYTCLVENAVGSIRYNYL--LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275
D+G Y CL ++ R+ + L VLER P + L TT++ G +E+ C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLENQTTSI-GESIEVSCTASG 692
Query: 276 DAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
+ P I W K N + G VLK + N L +R V ED G YTC A
Sbjct: 693 NPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVRKEDEGLYTCQA 739
Query: 336 GNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQAL 395
+ +G + A+ + ++ T IIL + +A+ LLL + R
Sbjct: 740 CSVLGCAKVEAFFIIEGAQEKT--------NLEIIILVGTAVIAMFFWLLLVIILR---- 787
Query: 396 HGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSL--- 452
TV++ ++G L G +S+
Sbjct: 788 ---------TVKR-------------------------------ANGGELKTGYLSIVMD 807
Query: 453 --DLPLDP----------LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTV 500
+LPLD WEFPRDRL LGKPLG G FGQV+ A+AFG+D + TV
Sbjct: 808 PDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGID--KTATCRTV 865
Query: 501 AVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG-PLYVIVECAAKGNLR 559
AVKMLK+ A+ + L+SE++++ IG H N++NLLG CT+ G PL VIVE GNL
Sbjct: 866 AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLS 925
Query: 560 EFLRARRPPGPDLSPDGPRSSEGP------------------------------------ 583
+LR++R G R +G
Sbjct: 926 TYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSD 985
Query: 584 --------------LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 629
L+ L+ ++QVA+GM++L SRKCIHRDLAARN+L++E NV+KI
Sbjct: 986 VEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 1045
Query: 630 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP 689
DFGLAR ++ Y + + RLP+KWMAPE +FDRVYT QSDVWSFG+LLWEIF+LG SP
Sbjct: 1046 DFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP 1105
Query: 690 YPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748
YPG+ ++E F L+EG RM P + PE+Y M +CWH PSQRPTF +LVE L +L
Sbjct: 1106 YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 1165
Query: 749 AVSEE 753
A +++
Sbjct: 1166 ANAQQ 1170
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224
G +++ C A+GNP P I W KD + ++ GI L+ + +L + V D G YTC
Sbjct: 681 GESIEVSCTASGNPPPQIMWFKDNETLVEDS---GIVLKDGNRNLTIRRVRKEDEGLYTC 737
Query: 225 LVENAVG 231
+ +G
Sbjct: 738 QACSVLG 744
Score = 41.6 bits (96), Expect = 0.003
Identities = 42/199 (21%), Positives = 72/199 (36%), Gaps = 33/199 (16%)
Query: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
L I D G Y C A ++ +N T + +
Sbjct: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR-------------------------VHE 326
Query: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
P+ ME + A G V+ G P P I+W K+G + I +
Sbjct: 327 KPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAG 380
Query: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
H +ME V D G YT ++ N + + ++++ ++ P + ++ + + G+
Sbjct: 381 HVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGT 439
Query: 266 DVELLCKVYSDAQP-HIQW 283
L C VY+ P HI W
Sbjct: 440 TQTLTCTVYAIPPPHHIHW 458
Score = 39.3 bits (90), Expect = 0.015
Identities = 35/140 (25%), Positives = 57/140 (40%), Gaps = 22/140 (15%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ--AGLPANTTAVVGS 265
+L ++ V SD+G YTC + + + + + + V E+ P + +G+ + A VG
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 266 DVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSA 325
V + K P I+W K +G P ++ VL + VS
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
Query: 326 EDAGEYTCLAGNSIGLSYQS 345
D G YT + N I QS
Sbjct: 391 RDTGNYTVILTNPISKEKQS 410
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 304 bits (778), Expect = 2e-82
Identities = 212/601 (35%), Positives = 296/601 (49%), Gaps = 119/601 (19%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDV 267
+L + +V D GTY C N ++ R P L L +T A+ S
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI-SSST 678
Query: 268 ELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAED 327
L C +P I W K+ N G I L++ V+ ED
Sbjct: 679 TLDCHANGVPEPQITWFKN---NHKIQQEPGI----------ILGPGSSTLFIERVTEED 725
Query: 328 AGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLA 387
G Y C A N G SA+LTV D + ++I +A + LL
Sbjct: 726 EGVYHCKATNQKGSVESSAYLTVQGTSDKS---------NLELITLTCTCVAATLFWLLL 776
Query: 388 GLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLA 447
L+ ++K+ R SSS ++ LS +
Sbjct: 777 TLF---------------IRKMKR-----------------SSSEIKTDYLSI---IMDP 801
Query: 448 GLVSLD-----LPLDPL-WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVA 501
V LD LP D WEF R+RL LGK LG G FG+VV+A AFG+ + TVA
Sbjct: 802 DEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIK--KSPTCRTVA 859
Query: 502 VKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG-PLYVIVECAAKGNLRE 560
VKMLK+ A+ + L++E++++ IG H N++NLLG CT++G PL VIVE GNL
Sbjct: 860 VKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSN 919
Query: 561 FLRARR--------------PPGPDLSP----------DGPRSSEG-------------- 582
+L+++R P + P D SSE
Sbjct: 920 YLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSD 979
Query: 583 -------------PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 629
P++ L+S ++QVARGM++L SRKCIHRDLAARN+L++E+NV+KI
Sbjct: 980 VEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKIC 1039
Query: 630 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP 689
DFGLAR ++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+G+LLWEIF+LGGSP
Sbjct: 1040 DFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSP 1099
Query: 690 YPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748
YPG+ ++E F S LREG RM P + PE+Y +M +CWH P +RP F +LVE L +L
Sbjct: 1100 YPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQ 1159
Query: 749 A 749
A
Sbjct: 1160 A 1160
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/141 (23%), Positives = 58/141 (41%), Gaps = 10/141 (7%)
Query: 150 THPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSL 209
T R ++ L V + + P+P + WLKDG ++ R + +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKS----ARYLTRGYSL 390
Query: 210 VMESVVPSDRGTYTCLV----ENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
+++ V D G YT L+ N ++ +++V + + + + P +GS
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 266 DVELLCKVYSDAQPHIQWLKH 286
L C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
Score = 43.1 bits (100), Expect = 0.001
Identities = 42/156 (26%), Positives = 58/156 (37%), Gaps = 28/156 (17%)
Query: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
L I + +D+G Y C AR + TG+ + + + RD Q+
Sbjct: 621 LTIMNVSLQDSGTYACRARN---------VYTGEEILQKKEI----TIRD--------QE 659
Query: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
APY H V ++ C A G P P I W K+ E GI L
Sbjct: 660 APYLLR----NLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPG 712
Query: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDV 241
+L +E V D G Y C N GS+ + L V
Sbjct: 713 SSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
Score = 38.5 bits (88), Expect = 0.025
Identities = 51/216 (23%), Positives = 78/216 (36%), Gaps = 61/216 (28%)
Query: 163 PAGNTVKFRCPAAGNPTPTIRW------------------------LKDGQAFHGENRIG 198
P G+ C A G P PTI+W + D + G NRI
Sbjct: 445 PLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG-NRIE 503
Query: 199 GIRLRH---QHWSLVMESVVPSDR---GTYTCLVENAVGSIRYN---YLLDV-------L 242
I R + + + ++V +D G Y C+ N VG++ N Y+ DV L
Sbjct: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
Query: 243 ERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYV 302
E+ P G D++L C V + W+ +N + +
Sbjct: 564 EKMP---------------TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS----I 604
Query: 303 QVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGN 337
K A + + L + NVS +D+G Y C A N
Sbjct: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
Score = 32.0 bits (71), Expect = 2.3
Identities = 37/169 (21%), Positives = 66/169 (39%), Gaps = 16/169 (9%)
Query: 209 LVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVE 268
L ++ + D+G YTC V + N + + +++ + T
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKA-FITVKHRKQQVLETVAGKRSYR 354
Query: 269 LLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDA 328
L KV + P + WLK DG P + K+A + ++ +++V+ EDA
Sbjct: 355 LSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYSLI-IKDVTEEDA 400
Query: 329 GEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGS 377
G YT L +++ T++ P A + + D LY GS
Sbjct: 401 GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS-FPDPALYPLGS 448
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 259 bits (661), Expect = 9e-69
Identities = 124/210 (59%), Positives = 155/210 (73%), Gaps = 9/210 (4%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
Query: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
Query: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
Query: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLK 306
QPHIQWLKHI +NGS G D PYVQ+LK
Sbjct: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 259 bits (661), Expect = 9e-69
Identities = 124/212 (58%), Positives = 156/212 (73%), Gaps = 11/212 (5%)
Query: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
Query: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
Query: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
Query: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLK 306
SD QPHIQWLKHI +NGS G D PYVQ+LK
Sbjct: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 249 bits (636), Expect = 7e-66
Identities = 164/418 (39%), Positives = 227/418 (54%), Gaps = 39/418 (9%)
Query: 361 AAPEARYTDIILYASGSLALAVLLLLAGLY-----RGQALHGRHPRPPATVQKLSRFPLA 415
AA E +IL GS++ L +LA L R LH R
Sbjct: 752 AAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRR----------------- 794
Query: 416 RQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 475
R F+ +SGS ++ G + P L +S P+ E+ + + +GE
Sbjct: 795 RTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSY-----PVLEW--EDITFEDLIGE 847
Query: 476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 535
G FGQV+RA + A+KMLK+ AS+ D D E+EV+ +G H NIIN
Sbjct: 848 GNFGQVIRAMI-----KKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIIN 902
Query: 536 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 595
LLG C G LY+ +E A GNL +FLR R D + + LS L+ A
Sbjct: 903 LLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASD 962
Query: 596 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 655
A GMQYL ++ IHRDLAARNVLV E+ KIADFGL+RG + Y K + GRLPV+W
Sbjct: 963 AANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRW 1019
Query: 656 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 715
MA E+L VYT +SDVWSFG+LLWEI +LGG+PY G+ EL+ L +G+RM++P +C
Sbjct: 1020 MAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCD 1079
Query: 716 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASS 773
E+Y LMR+CW P +RP F Q+ L ++L A + Y+++ L F ++ +G DA++
Sbjct: 1080 DEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA-RKAYVNMSL-FENFTYAGIDATA 1135
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 242 bits (617), Expect = 1e-63
Identities = 150/401 (37%), Positives = 208/401 (51%), Gaps = 71/401 (17%)
Query: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
LP D WEFPR+RL GK LG G FG+VV A A+G+ + D A TVAVKMLK +A +
Sbjct: 572 LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGL--IKSDAAMTVAVKMLKPSAHLTE 629
Query: 514 LADLVSE----------MEVMKLIGR---------------HKNIINLLG------VCTQ 542
L+SE M ++ L+G + +++N L +C++
Sbjct: 630 REALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSK 689
Query: 543 -----EGPLY------------------------VIVECAAKGNLREFLRARRPPGPDLS 573
E LY V K + R +R D++
Sbjct: 690 QEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVT 749
Query: 574 PDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGL 633
P E L L+S +YQVA+GM +L S+ CIHRDLAARN+L+T + KI DFGL
Sbjct: 750 PAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 809
Query: 634 ARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI 693
AR + + Y N RLPVKWMAPE++F+ VYT +SDVWS+GI LWE+F+LG SPYPG+
Sbjct: 810 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 869
Query: 694 PVE-ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 752
PV+ + + +++EG RM P H P E+Y +M+ CW A P +RPTFKQ+V+ ++K + +
Sbjct: 870 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 929
Query: 753 EYLDLRLTFGP--------YSPSGGDASSTCSSSDSVFSHD 785
P +S ST SSS + HD
Sbjct: 930 HIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHD 970
Score = 34.7 bits (78), Expect = 0.36
Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 13/134 (9%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVV--GS 265
+L + S +D G + C N GS L+V+++ + NTT V G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 266 DVELLCKVYSDAQP-HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVS 324
+V+L+ + + +P H QW + +F Y + + N V L+L +
Sbjct: 330 NVDLIVEYEAFPKPEHQQW----IYMNRTFTDKWEDYPK--SENESNIRYVSELHLTRLK 383
Query: 325 AEDAGEYTCLAGNS 338
+ G YT L NS
Sbjct: 384 GTEGGTYTFLVSNS 397
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 242 bits (617), Expect = 1e-63
Identities = 150/401 (37%), Positives = 208/401 (51%), Gaps = 71/401 (17%)
Query: 454 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 513
LP D WEFPR+RL GK LG G FG+VV A A+G+ + D A TVAVKMLK +A +
Sbjct: 576 LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGL--IKSDAAMTVAVKMLKPSAHLTE 633
Query: 514 LADLVSE----------MEVMKLIGR---------------HKNIINLLG------VCTQ 542
L+SE M ++ L+G + +++N L +C++
Sbjct: 634 REALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSK 693
Query: 543 -----EGPLY------------------------VIVECAAKGNLREFLRARRPPGPDLS 573
E LY V K + R +R D++
Sbjct: 694 QEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVT 753
Query: 574 PDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGL 633
P E L L+S +YQVA+GM +L S+ CIHRDLAARN+L+T + KI DFGL
Sbjct: 754 PAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 813
Query: 634 ARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI 693
AR + + Y N RLPVKWMAPE++F+ VYT +SDVWS+GI LWE+F+LG SPYPG+
Sbjct: 814 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 873
Query: 694 PVE-ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 752
PV+ + + +++EG RM P H P E+Y +M+ CW A P +RPTFKQ+V+ ++K + +
Sbjct: 874 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 933
Query: 753 EYLDLRLTFGP--------YSPSGGDASSTCSSSDSVFSHD 785
P +S ST SSS + HD
Sbjct: 934 HIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHD 974
Score = 34.7 bits (78), Expect = 0.36
Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 13/134 (9%)
Query: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVV--GS 265
+L + S +D G + C N GS L+V+++ + NTT V G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 266 DVELLCKVYSDAQP-HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVS 324
+V+L+ + + +P H QW + +F Y + + N V L+L +
Sbjct: 330 NVDLIVEYEAFPKPEHQQW----IYMNRTFTDKWEDYPK--SENESNIRYVSELHLTRLK 383
Query: 325 AEDAGEYTCLAGNS 338
+ G YT L NS
Sbjct: 384 GTEGGTYTFLVSNS 397
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 241 bits (615), Expect = 2e-63
Identities = 131/275 (47%), Positives = 177/275 (64%), Gaps = 8/275 (2%)
Query: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532
+GEG FGQV++A D R D A+K +K+ AS D D E+EV+ +G H N
Sbjct: 830 IGEGNFGQVLKAR-IKKDGLRMD----AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592
IINLLG C G LY+ +E A GNL +FLR R D + S+ LS L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652
A VARGM YL ++ IHRDLAARN+LV E+ V KIADFGL+RG + Y K + GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
Query: 653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 712
V+WMA E+L VYT SDVWS+G+LLWEI +LGG+PY G+ EL+ L +G+R+++P
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 713 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
+C E+Y LMR+CW P +RP+F Q++ +L+++L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,151,394
Number of Sequences: 37866
Number of extensions: 1774705
Number of successful extensions: 11501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 327
Number of HSP's that attempted gapping in prelim test: 5282
Number of HSP's gapped (non-prelim): 3316
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.