Guide to the Human Genome
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Search of human proteins with 47458041

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
         (458 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s...   922   0.0  
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ...   864   0.0  
gi|239755174 PREDICTED: similar to solute carrier family 25, mem...   603   e-172
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ...   603   e-172
gi|48476342 solute carrier family 25, member 23 [Homo sapiens]        594   e-170
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ...   585   e-167
gi|239755176 PREDICTED: similar to solute carrier family 25, mem...   584   e-167
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ...   584   e-167
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ...   514   e-146
gi|149274607 solute carrier family 25, member 41 [Homo sapiens]       320   2e-87
gi|27544933 solute carrier family 25, member 16 [Homo sapiens]        182   4e-46
gi|60460887 solute carrier family 25, member 42 [Homo sapiens]        181   1e-45
gi|156071462 solute carrier family 25, member A6 [Homo sapiens]       137   2e-32
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade...   132   7e-31
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade...   131   1e-30
gi|156071459 solute carrier family 25, member 5 [Homo sapiens]        131   1e-30
gi|21687151 mitochondrial solute carrier protein [Homo sapiens]       127   2e-29
gi|21314739 solute carrier family 25, member 32 [Homo sapiens]        119   7e-27
gi|186928856 solute carrier family 25, member 19 [Homo sapiens]       109   5e-24
gi|186928860 solute carrier family 25, member 19 [Homo sapiens]       109   5e-24
gi|186928858 solute carrier family 25, member 19 [Homo sapiens]       109   5e-24
gi|157388989 solute carrier family 25, member 36 isoform a [Homo...   108   1e-23
gi|157388991 solute carrier family 25, member 36 isoform b [Homo...   104   1e-22
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho...   104   1e-22
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H...   104   1e-22
gi|21361103 solute carrier family 25, member 12 [Homo sapiens]        102   7e-22
gi|46094065 mitochondrial carrier family protein [Homo sapiens]       100   3e-21
gi|58197562 solute carrier family 25, member 30 [Homo sapiens]         98   1e-20
gi|82775373 solute carrier family 25, member 37 [Homo sapiens]         97   2e-20
gi|7706306 solute carrier family 25, member 39 isoform b [Homo s...    97   2e-20

>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
           sapiens]
          Length = 458

 Score =  922 bits (2382), Expect = 0.0
 Identities = 458/458 (100%), Positives = 458/458 (100%)

Query: 1   MDSLYGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEE 60
           MDSLYGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEE
Sbjct: 1   MDSLYGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEE 60

Query: 61  FMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGT 120
           FMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGT
Sbjct: 61  FMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGT 120

Query: 121 MTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLL 180
           MTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLL
Sbjct: 121 MTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLL 180

Query: 181 AGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVI 240
           AGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVI
Sbjct: 181 AGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVI 240

Query: 241 KIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVG 300
           KIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVG
Sbjct: 241 KIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVG 300

Query: 301 KTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKD 360
           KTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKD
Sbjct: 301 KTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKD 360

Query: 361 SVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEG 420
           SVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEG
Sbjct: 361 SVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEG 420

Query: 421 IPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           IPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK
Sbjct: 421 IPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458


>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
           sapiens]
          Length = 477

 Score =  864 bits (2233), Expect = 0.0
 Identities = 433/454 (95%), Positives = 438/454 (96%)

Query: 5   YGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEEFMKY 64
           Y  LF  LD N DG +DI ELQEGL ++G     +  +KIFTTGDVNKDGKLDFEEFMKY
Sbjct: 24  YETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKY 83

Query: 65  LKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVD 124
           LKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVD
Sbjct: 84  LKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVD 143

Query: 125 WNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGI 184
           WNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGI
Sbjct: 144 WNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGI 203

Query: 185 AGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAP 244
           AGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAP
Sbjct: 204 AGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAP 263

Query: 245 ETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQ 304
           ETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQ
Sbjct: 264 ETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQ 323

Query: 305 YSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNP 364
           YSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNP
Sbjct: 324 YSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNP 383

Query: 365 GVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGL 424
           GVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGL
Sbjct: 384 GVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGL 443

Query: 425 YRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           YRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK
Sbjct: 444 YRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 477


>gi|239755174 PREDICTED: similar to solute carrier family 25, member
           25 isoform 1 [Homo sapiens]
          Length = 503

 Score =  603 bits (1554), Expect = e-172
 Identities = 289/451 (64%), Positives = 365/451 (80%)

Query: 8   LFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEEFMKYLKD 67
           LF  LD N+DG L + +L  GL  +G  ++  E +KI   GD + DG+LDFEEF+ YL+D
Sbjct: 53  LFQTLDVNRDGGLCVNDLAVGLRRLGLHRTEGELQKIVQAGDKDLDGQLDFEEFVHYLQD 112

Query: 68  HEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNE 127
           HEKK++L FKSLDK NDG+I+A EI+QSL+ LG+ ISEQQAE IL+S+D +GTMT+DWNE
Sbjct: 113 HEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNE 172

Query: 128 WRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGA 187
           WRDY L +PV +I EII +WKHST  D+G++LT+PDEFT +E+++G WWR L+AGG AGA
Sbjct: 173 WRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGA 232

Query: 188 VSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETA 247
           VSRT TAPLDRLK++MQVH S+S+ M I GGF QM++EGG RSLWRGNG NV+KIAPE+A
Sbjct: 233 VSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESA 292

Query: 248 VKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSG 307
           +KF AYEQ K+L+  + + +   ER ++GS+AGA AQ+ IYPMEV+KTR+A+ KTGQYSG
Sbjct: 293 IKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSG 352

Query: 308 IYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVM 367
           + DCA++IL  EG+ AFYKGYVPN+LGIIPYAGIDLAVYE LK+ WL ++A +S +PGV 
Sbjct: 353 MLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVF 412

Query: 368 VLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRG 427
           VLL CG +SSTCGQLASYPLALVRTRMQAQA +EG+P++ M  LF+ I+  EG  GLYRG
Sbjct: 413 VLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRG 472

Query: 428 ITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           + PNFMKV+PAV ISYVVYEN+K TLGV  +
Sbjct: 473 LAPNFMKVIPAVSISYVVYENLKITLGVQSR 503



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 86/388 (22%), Positives = 165/388 (42%), Gaps = 41/388 (10%)

Query: 67  DHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWN 126
           DH  ++   F++LD N DG +  +++   L+ LGL  +E + + I+Q+ D D    +D+ 
Sbjct: 45  DHRLRLWRLFQTLDVNRDGGLCVNDLAVGLRRLGLHRTEGELQKIVQAGDKDLDGQLDFE 104

Query: 127 EWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAG 186
           E+  Y     + D E+ +R    S                 D+K  G+   Q +   +  
Sbjct: 105 EFVHY-----LQDHEKKLRLVFKSL----------------DKKNDGRIDAQEIMQSLRD 143

Query: 187 AVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSL---WRGNGTNVIKIA 243
              + S    +++   M  +G+ +   N +  +  +     I  +   W+   + +  + 
Sbjct: 144 LGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWK--HSTIFDVG 201

Query: 244 PETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV-GKT 302
               V         +   EE Q    +   ++G  AGA ++T   P++ +K  + V    
Sbjct: 202 ENLTVP-------DEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR 254

Query: 303 GQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSV 362
               GI     ++++  G  + ++G   N+L I P + I    YE +K         D  
Sbjct: 255 SNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRL----VGSDQE 310

Query: 363 NPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIP 422
              +   L  G+L+    Q + YP+ +++TRM   A+ +      M+   RRI+++EG+ 
Sbjct: 311 TLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM---ALRKTGQYSGMLDCARRILAREGVA 367

Query: 423 GLYRGITPNFMKVLPAVGISYVVYENMK 450
             Y+G  PN + ++P  GI   VYE +K
Sbjct: 368 AFYKGYVPNMLGIIPYAGIDLAVYETLK 395


>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
           sapiens]
          Length = 503

 Score =  603 bits (1554), Expect = e-172
 Identities = 289/451 (64%), Positives = 365/451 (80%)

Query: 8   LFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEEFMKYLKD 67
           LF  LD N+DG L + +L  GL  +G  ++  E +KI   GD + DG+LDFEEF+ YL+D
Sbjct: 53  LFQTLDVNRDGGLCVNDLAVGLRRLGLHRTEGELQKIVQAGDKDLDGQLDFEEFVHYLQD 112

Query: 68  HEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNE 127
           HEKK++L FKSLDK NDG+I+A EI+QSL+ LG+ ISEQQAE IL+S+D +GTMT+DWNE
Sbjct: 113 HEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNE 172

Query: 128 WRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGA 187
           WRDY L +PV +I EII +WKHST  D+G++LT+PDEFT +E+++G WWR L+AGG AGA
Sbjct: 173 WRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGA 232

Query: 188 VSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETA 247
           VSRT TAPLDRLK++MQVH S+S+ M I GGF QM++EGG RSLWRGNG NV+KIAPE+A
Sbjct: 233 VSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESA 292

Query: 248 VKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSG 307
           +KF AYEQ K+L+  + + +   ER ++GS+AGA AQ+ IYPMEV+KTR+A+ KTGQYSG
Sbjct: 293 IKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSG 352

Query: 308 IYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVM 367
           + DCA++IL  EG+ AFYKGYVPN+LGIIPYAGIDLAVYE LK+ WL ++A +S +PGV 
Sbjct: 353 MLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVF 412

Query: 368 VLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRG 427
           VLL CG +SSTCGQLASYPLALVRTRMQAQA +EG+P++ M  LF+ I+  EG  GLYRG
Sbjct: 413 VLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRG 472

Query: 428 ITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           + PNFMKV+PAV ISYVVYEN+K TLGV  +
Sbjct: 473 LAPNFMKVIPAVSISYVVYENLKITLGVQSR 503



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 86/388 (22%), Positives = 165/388 (42%), Gaps = 41/388 (10%)

Query: 67  DHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWN 126
           DH  ++   F++LD N DG +  +++   L+ LGL  +E + + I+Q+ D D    +D+ 
Sbjct: 45  DHRLRLWRLFQTLDVNRDGGLCVNDLAVGLRRLGLHRTEGELQKIVQAGDKDLDGQLDFE 104

Query: 127 EWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAG 186
           E+  Y     + D E+ +R    S                 D+K  G+   Q +   +  
Sbjct: 105 EFVHY-----LQDHEKKLRLVFKSL----------------DKKNDGRIDAQEIMQSLRD 143

Query: 187 AVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSL---WRGNGTNVIKIA 243
              + S    +++   M  +G+ +   N +  +  +     I  +   W+   + +  + 
Sbjct: 144 LGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWK--HSTIFDVG 201

Query: 244 PETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV-GKT 302
               V         +   EE Q    +   ++G  AGA ++T   P++ +K  + V    
Sbjct: 202 ENLTVP-------DEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR 254

Query: 303 GQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSV 362
               GI     ++++  G  + ++G   N+L I P + I    YE +K         D  
Sbjct: 255 SNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRL----VGSDQE 310

Query: 363 NPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIP 422
              +   L  G+L+    Q + YP+ +++TRM   A+ +      M+   RRI+++EG+ 
Sbjct: 311 TLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM---ALRKTGQYSGMLDCARRILAREGVA 367

Query: 423 GLYRGITPNFMKVLPAVGISYVVYENMK 450
             Y+G  PN + ++P  GI   VYE +K
Sbjct: 368 AFYKGYVPNMLGIIPYAGIDLAVYETLK 395


>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
          Length = 468

 Score =  594 bits (1531), Expect = e-170
 Identities = 281/455 (61%), Positives = 365/455 (80%), Gaps = 1/455 (0%)

Query: 5   YGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKK-IFTTGDVNKDGKLDFEEFMK 63
           +G LF  LD NKDG +D+ EL++GL  +G       A++ I + GD + DG LD EEF +
Sbjct: 14  WGRLFEELDSNKDGRVDVHELRQGLARLGGGNPDPGAQQGISSEGDADPDGGLDLEEFSR 73

Query: 64  YLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTV 123
           YL++ E+++ L F SLD+N DG I+ SEI QS + LG++IS +QAE IL S+D DGTMT+
Sbjct: 74  YLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTMTI 133

Query: 124 DWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGG 183
           DW EWRD+FL + + ++E+++ FWKHST +DIG+ LT+PDEF++ EK +G WW+QL+AG 
Sbjct: 134 DWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGA 193

Query: 184 IAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIA 243
           +AGAVSRT TAPLDRLK+ MQVH SK++++NI GG R MV EGGIRSLWRGNG NV+KIA
Sbjct: 194 VAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIA 253

Query: 244 PETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTG 303
           PE+A+KF AYEQ K+ +  + + +   ERF++GS+AGATAQT IYPMEV+KTRL + +TG
Sbjct: 254 PESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTG 313

Query: 304 QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVN 363
           QY G+ DCA++IL+ EG  AFY+GY+PN+LGIIPYAGIDLAVYE LK++WL  ++ DS +
Sbjct: 314 QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSAD 373

Query: 364 PGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPG 423
           PG++VLL CG +SSTCGQ+ASYPLALVRTRMQAQA +EG PQL+M+GL R I+S+EG+ G
Sbjct: 374 PGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRG 433

Query: 424 LYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           LYRGI PNFMKV+PAV ISYVVYENMKQ LGVT +
Sbjct: 434 LYRGIAPNFMKVIPAVSISYVVYENMKQALGVTSR 468


>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
           sapiens]
          Length = 489

 Score =  585 bits (1509), Expect = e-167
 Identities = 277/417 (66%), Positives = 346/417 (82%)

Query: 42  KKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGL 101
           KKI   GD + DG+LDFEEF+ YL+DHEKK++L FKSLDK NDG+I+A EI+QSL+ LG+
Sbjct: 73  KKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGV 132

Query: 102 TISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTI 161
            ISEQQAE IL+S+D +GTMT+DWNEWRDY L +PV +I EII +WKHST  D+G++LT+
Sbjct: 133 KISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTV 192

Query: 162 PDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQ 221
           PDEFT +E+++G WWR L+AGG AGAVSRT TAPLDRLK++MQVH S+S+ M I GGF Q
Sbjct: 193 PDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQ 252

Query: 222 MVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGA 281
           M++EGG RSLWRGNG NV+KIAPE+A+KF AYEQ K+L+  + + +   ER ++GS+AGA
Sbjct: 253 MIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGA 312

Query: 282 TAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGI 341
            AQ+ IYPMEV+KTR+A+ KTGQYSG+ DCA++IL  EG+ AFYKGYVPN+LGIIPYAGI
Sbjct: 313 IAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGI 372

Query: 342 DLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLE 401
           DLAVYE LK+ WL ++A +S +PGV VLL CG +SSTCGQLASYPLALVRTRMQAQA +E
Sbjct: 373 DLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIE 432

Query: 402 GSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           G+P++ M  LF+ I+  EG  GLYRG+ PNFMKV+PAV ISYVVYEN+K TLGV  +
Sbjct: 433 GAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR 489


>gi|239755176 PREDICTED: similar to solute carrier family 25, member
           25 isoform 2 [Homo sapiens]
          Length = 469

 Score =  584 bits (1505), Expect = e-167
 Identities = 276/417 (66%), Positives = 346/417 (82%)

Query: 42  KKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGL 101
           +KI   GD + DG+LDFEEF+ YL+DHEKK++L FKSLDK NDG+I+A EI+QSL+ LG+
Sbjct: 53  QKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGV 112

Query: 102 TISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTI 161
            ISEQQAE IL+S+D +GTMT+DWNEWRDY L +PV +I EII +WKHST  D+G++LT+
Sbjct: 113 KISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTV 172

Query: 162 PDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQ 221
           PDEFT +E+++G WWR L+AGG AGAVSRT TAPLDRLK++MQVH S+S+ M I GGF Q
Sbjct: 173 PDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQ 232

Query: 222 MVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGA 281
           M++EGG RSLWRGNG NV+KIAPE+A+KF AYEQ K+L+  + + +   ER ++GS+AGA
Sbjct: 233 MIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGA 292

Query: 282 TAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGI 341
            AQ+ IYPMEV+KTR+A+ KTGQYSG+ DCA++IL  EG+ AFYKGYVPN+LGIIPYAGI
Sbjct: 293 IAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGI 352

Query: 342 DLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLE 401
           DLAVYE LK+ WL ++A +S +PGV VLL CG +SSTCGQLASYPLALVRTRMQAQA +E
Sbjct: 353 DLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIE 412

Query: 402 GSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           G+P++ M  LF+ I+  EG  GLYRG+ PNFMKV+PAV ISYVVYEN+K TLGV  +
Sbjct: 413 GAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR 469


>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
           sapiens]
          Length = 469

 Score =  584 bits (1505), Expect = e-167
 Identities = 276/417 (66%), Positives = 346/417 (82%)

Query: 42  KKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGL 101
           +KI   GD + DG+LDFEEF+ YL+DHEKK++L FKSLDK NDG+I+A EI+QSL+ LG+
Sbjct: 53  QKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGV 112

Query: 102 TISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTI 161
            ISEQQAE IL+S+D +GTMT+DWNEWRDY L +PV +I EII +WKHST  D+G++LT+
Sbjct: 113 KISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTV 172

Query: 162 PDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQ 221
           PDEFT +E+++G WWR L+AGG AGAVSRT TAPLDRLK++MQVH S+S+ M I GGF Q
Sbjct: 173 PDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQ 232

Query: 222 MVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGA 281
           M++EGG RSLWRGNG NV+KIAPE+A+KF AYEQ K+L+  + + +   ER ++GS+AGA
Sbjct: 233 MIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGA 292

Query: 282 TAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGI 341
            AQ+ IYPMEV+KTR+A+ KTGQYSG+ DCA++IL  EG+ AFYKGYVPN+LGIIPYAGI
Sbjct: 293 IAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGI 352

Query: 342 DLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLE 401
           DLAVYE LK+ WL ++A +S +PGV VLL CG +SSTCGQLASYPLALVRTRMQAQA +E
Sbjct: 353 DLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIE 412

Query: 402 GSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
           G+P++ M  LF+ I+  EG  GLYRG+ PNFMKV+PAV ISYVVYEN+K TLGV  +
Sbjct: 413 GAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR 469


>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
           sapiens]
          Length = 366

 Score =  514 bits (1325), Expect = e-146
 Identities = 243/366 (66%), Positives = 304/366 (83%)

Query: 93  VQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTG 152
           +QSL+ LG+ ISEQQAE IL+S+D +GTMT+DWNEWRDY L +PV +I EII +WKHST 
Sbjct: 1   MQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTI 60

Query: 153 IDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDK 212
            D+G++LT+PDEFT +E+++G WWR L+AGG AGAVSRT TAPLDRLK++MQVH S+S+ 
Sbjct: 61  FDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN 120

Query: 213 MNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFER 272
           M I GGF QM++EGG RSLWRGNG NV+KIAPE+A+KF AYEQ K+L+  + + +   ER
Sbjct: 121 MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHER 180

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNL 332
            ++GS+AGA AQ+ IYPMEV+KTR+A+ KTGQYSG+ DCA++IL  EG+ AFYKGYVPN+
Sbjct: 181 LVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNM 240

Query: 333 LGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRT 392
           LGIIPYAGIDLAVYE LK+ WL ++A +S +PGV VLL CG +SSTCGQLASYPLALVRT
Sbjct: 241 LGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRT 300

Query: 393 RMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQT 452
           RMQAQA +EG+P++ M  LF+ I+  EG  GLYRG+ PNFMKV+PAV ISYVVYEN+K T
Sbjct: 301 RMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKIT 360

Query: 453 LGVTQK 458
           LGV  +
Sbjct: 361 LGVQSR 366


>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
          Length = 370

 Score =  320 bits (819), Expect = 2e-87
 Identities = 166/303 (54%), Positives = 218/303 (71%), Gaps = 3/303 (0%)

Query: 153 IDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDK 212
           +D G+ L +P E  E + K   W + LL+G +AGAVSRT TAPLDR K+ MQV+ SK++ 
Sbjct: 71  LDTGEQLMVPVEVLEVDNKEALW-KFLLSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTNF 129

Query: 213 MNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFER 272
            N+ GG + MV+EGG RSLWRGNG NV+KIAPE A+KF  +EQ K             ER
Sbjct: 130 TNLLGGLQSMVQEGGFRSLWRGNGINVLKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQER 189

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNL 332
            ++GS+A A +QT I PMEV+KTRL + +TGQY G+ DCA++IL+ EG  A Y+GY+PN+
Sbjct: 190 LLAGSLAVAISQTLINPMEVLKTRLTLRRTGQYKGLLDCARQILQREGTRALYRGYLPNM 249

Query: 333 LGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRT 392
           LGIIPYA  DLAVYE+L+ +W+ +  +D  +P  +V L    LS+TCGQ+ASYPL LVRT
Sbjct: 250 LGIIPYACTDLAVYEMLQCFWVKS-GRDMGDPSGLVSLSSVTLSTTCGQMASYPLTLVRT 308

Query: 393 RMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQT 452
           RMQAQ  +EGS    M G+ +RI++++G  GLYRG+TP  +KVLPA GISYVVYE MK+T
Sbjct: 309 RMQAQDTVEGS-NPTMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKT 367

Query: 453 LGV 455
           LG+
Sbjct: 368 LGI 370


>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
          Length = 332

 Score =  182 bits (463), Expect = 4e-46
 Identities = 107/292 (36%), Positives = 161/292 (55%), Gaps = 15/292 (5%)

Query: 175 WWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRG 234
           W R  LAGGIAG  ++T+ APLDR+K+++Q H      + +F   R + ++ G   L++G
Sbjct: 36  WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKG 95

Query: 235 NGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMK 294
           NG  +I+I P  A++F A+E YK L+T +    G   R ++GSMAG TA    YP+++++
Sbjct: 96  NGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVR 155

Query: 295 TRLAVGKTGQ--YSGIYDCAKKI-LKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKS 351
            RLA    G+  Y+GI    K I  K  G   FY+G +P +LG+ PYAG+    +  LKS
Sbjct: 156 VRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKS 215

Query: 352 YWLDNF-----AKDSVNPGVMVL-----LGCGALSSTCGQLASYPLALVRTRMQAQAML- 400
             L +         S NP V+VL     L CG ++    Q  SYP  + R RMQ   +L 
Sbjct: 216 VGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLP 275

Query: 401 EGSPQLNMVGLFRRIISKEGI-PGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
           E    L M    + +    GI  GLYRG++ N+++ +P+  +++  YE MKQ
Sbjct: 276 EFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 23/198 (11%)

Query: 178 QLLAGGIAGAVSRTSTAPLD--RLKIMMQVHGSKSDKMNIFGGFRQM-VKEGGIRSLWRG 234
           +L+AG +AG  +   T PLD  R+++  QV G  S    I   F+ +  KEGG    +RG
Sbjct: 133 RLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRG 191

Query: 235 NGTNVIKIAPETAVKFWAYEQYKKL-LTEEGQKIG-------------TFERFISGSMAG 280
               ++ +AP   V F+ +   K + L+     +G             T    + G +AG
Sbjct: 192 LMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG 251

Query: 281 ATAQTFIYPMEVMKTRLAVGKT----GQYSGIYDCAKKILKHEGLG-AFYKGYVPNLLGI 335
           A AQT  YP +V + R+ +G       +   + D  K +  H G+    Y+G   N +  
Sbjct: 252 AIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRC 311

Query: 336 IPYAGIDLAVYELLKSYW 353
           IP   +    YEL+K ++
Sbjct: 312 IPSQAVAFTTYELMKQFF 329


>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
          Length = 318

 Score =  181 bits (459), Expect = 1e-45
 Identities = 100/277 (36%), Positives = 160/277 (57%), Gaps = 8/277 (2%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 238
           LL G +AGA+++T+ APLDR KI+ QV   +      F          G  SLWRGN   
Sbjct: 37  LLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSAT 96

Query: 239 VIKIAPETAVKFWAYEQYKKLLTE----EGQKIGTFERFISGSMAGATAQTFIYPMEVMK 294
           ++++ P  A++F A+E+YK++L       G+ +  + R  +G++AG TA +  YP+++++
Sbjct: 97  MVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVR 156

Query: 295 TRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWL 354
            R+AV     YS I+    +I + EGL   Y G++P +LG+IPYAG+    YE LKS   
Sbjct: 157 ARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHR 216

Query: 355 DNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRR 414
           +   +    P   ++   GA +   GQ ASYPL +VR RMQ  A + G P+ ++    R 
Sbjct: 217 EYSGRRQPYPFERMIF--GACAGLIGQSASYPLDVVRRRMQT-AGVTGYPRASIARTLRT 273

Query: 415 IISKEG-IPGLYRGITPNFMKVLPAVGISYVVYENMK 450
           I+ +EG + GLY+G++ N++K   AVGIS+  ++ M+
Sbjct: 274 IVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDLMQ 310



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 55/180 (30%), Positives = 91/180 (50%), Gaps = 6/180 (3%)

Query: 176 WRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGN 235
           W +L AG +AG  + + T PLD ++  M V   K    NIF  F ++ +E G+++L+ G 
Sbjct: 132 WPRLFAGALAGTTAASLTYPLDLVRARMAV-TPKEMYSNIFHVFIRISREEGLKTLYHGF 190

Query: 236 GTNVIKIAPETAVKFWAYEQYKKLLTEEG--QKIGTFERFISGSMAGATAQTFIYPMEVM 293
              V+ + P   + F+ YE  K L  E    ++   FER I G+ AG   Q+  YP++V+
Sbjct: 191 MPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVV 250

Query: 294 KTRL-AVGKTG-QYSGIYDCAKKILKHEG-LGAFYKGYVPNLLGIIPYAGIDLAVYELLK 350
           + R+   G TG   + I    + I++ EG +   YKG   N +      GI    ++L++
Sbjct: 251 RRRMQTAGVTGYPRASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDLMQ 310



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 2/82 (2%)

Query: 373 GALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNF 432
           GAL+    + A  PL   +   Q  +    + +   V  +  +   EG   L+RG +   
Sbjct: 40  GALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYL--NEGFLSLWRGNSATM 97

Query: 433 MKVLPAVGISYVVYENMKQTLG 454
           ++V+P   I +  +E  K+ LG
Sbjct: 98  VRVVPYAAIQFSAHEEYKRILG 119


>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
          Length = 298

 Score =  137 bits (345), Expect = 2e-32
 Identities = 94/295 (31%), Positives = 155/295 (52%), Gaps = 24/295 (8%)

Query: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSK---SDKM--NIFGGFRQMVKEGGIRS 230
           +  LAGGIA A+S+T+ AP++R+K+++QV H SK   +DK    I     ++ KE G+ S
Sbjct: 10  KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69

Query: 231 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM-----AGATAQT 285
            WRGN  NVI+  P  A+ F   ++YK++      K   F R+ +G++     AGAT+  
Sbjct: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129

Query: 286 FIYPMEVMKTRLA--VGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAG 340
           F+YP++  +TRLA  VGK+G   ++ G+ DC  KI K +G+   Y+G+  ++ GII Y  
Sbjct: 130 FVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRA 189

Query: 341 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 400
               VY+  K         D  N  ++V        +    + SYP   VR RM  Q+  
Sbjct: 190 AYFGVYDTAK-----GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGR 244

Query: 401 EGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
           +G+  +    V  +R+I   EG    ++G   N ++ +    +  V+Y+ +K+ +
Sbjct: 245 KGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDELKKVI 298


>gi|13775208 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 31 [Homo
           sapiens]
          Length = 315

 Score =  132 bits (332), Expect = 7e-31
 Identities = 94/294 (31%), Positives = 145/294 (49%), Gaps = 28/294 (9%)

Query: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMV-------KEGGIR 229
           + LLAGG+A AVS+T+ AP++R+K+++QV  S S +++    ++ MV       +E G  
Sbjct: 22  KDLLAGGVAAAVSKTAVAPIERVKLLLQVQAS-SKQISPEARYKGMVDCLVRIPREQGFF 80

Query: 230 SLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFI-----SGSMAGATAQ 284
           S WRGN  NVI+  P  A+ F   ++YK+L      K   F R+      SG  AGAT+ 
Sbjct: 81  SFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSL 140

Query: 285 TFIYPMEVMKTRLAVG-----KTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYA 339
             +YP++  +TRL V      +  Q+ G+ DC  KI K +G+   Y+G+  ++ GII Y 
Sbjct: 141 CVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYR 200

Query: 340 GIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAM 399
                 Y+ +K        K    P  +V      + +TC  + SYP   VR RM  Q+ 
Sbjct: 201 ASYFGAYDTVKGL----LPKPKKTP-FLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSG 255

Query: 400 LEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVG--ISYVVYENMKQ 451
                    +  F +I   EGI   +RG    F  VL   G  +  V+Y+ +K+
Sbjct: 256 EAKRQYKGTLDCFVKIYQHEGISSFFRGA---FSNVLRGTGGALVLVLYDKIKE 306



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 44/196 (22%), Positives = 86/196 (43%), Gaps = 12/196 (6%)

Query: 274 ISGSMAGATAQTFIYPMEVMKTRLAVGKTGQ-------YSGIYDCAKKILKHEGLGAFYK 326
           ++G +A A ++T + P+E +K  L V  + +       Y G+ DC  +I + +G  +F++
Sbjct: 25  LAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFWR 84

Query: 327 GYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVN-PGVMVLLGCGALSSTCGQLASY 385
           G + N++   P   ++ A  +  K  ++    K+       +  L  G  +        Y
Sbjct: 85  GNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVVY 144

Query: 386 PLALVRTRMQAQAMLEGSPQLNMVGL---FRRIISKEGIPGLYRGITPNFMKVLPAVGIS 442
           PL   RTR+    + +G  +    GL     +I   +GI GLY+G   +   ++      
Sbjct: 145 PLDFARTRLGVD-IGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRASY 203

Query: 443 YVVYENMKQTLGVTQK 458
           +  Y+ +K  L   +K
Sbjct: 204 FGAYDTVKGLLPKPKK 219


>gi|55749577 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 4 [Homo
           sapiens]
          Length = 298

 Score =  131 bits (329), Expect = 1e-30
 Identities = 93/293 (31%), Positives = 147/293 (50%), Gaps = 24/293 (8%)

Query: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSKS-----DKMNIFGGFRQMVKEGGIRS 230
           +  LAGG+A AVS+T+ AP++R+K+++QV H SK          I     ++ KE G  S
Sbjct: 10  KDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLS 69

Query: 231 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM-----AGATAQT 285
            WRGN  NVI+  P  A+ F   ++YK+L      +   F R+ +G++     AGAT+  
Sbjct: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLC 129

Query: 286 FIYPMEVMKTRLA--VGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAG 340
           F+YP++  +TRLA  VGK     ++ G+ DC  KI K +GL   Y+G+  ++ GII Y  
Sbjct: 130 FVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRA 189

Query: 341 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 400
               VY+  K         D  N  + V        +    L SYP   VR RM  Q+  
Sbjct: 190 AYFGVYDTAK-----GMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGR 244

Query: 401 EGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
           +G+  +    V  +R+I   EG    ++G   N ++ +    +  V+Y+ +K+
Sbjct: 245 KGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFV-LVLYDEIKK 296



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 51/195 (26%), Positives = 86/195 (44%), Gaps = 18/195 (9%)

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAVGKTG-------QYSGIYDCAKKILKHEGLGAFY 325
           F++G +A A ++T + P+E +K  L V           QY GI DC  +I K +G  +F+
Sbjct: 12  FLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFW 71

Query: 326 KGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDS----VNPGVMVLLGCGALSSTCGQ 381
           +G + N++   P   ++ A  +  K  +L    +         G +   G    +S C  
Sbjct: 72  RGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLC-- 129

Query: 382 LASYPLALVRTRMQAQAMLEGSPQLNMVGL---FRRIISKEGIPGLYRGITPNFMKVLPA 438
              YPL   RTR+ A    +G+ Q    GL     +I   +G+ GLY+G   +   ++  
Sbjct: 130 -FVYPLDFARTRLAADVG-KGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIY 187

Query: 439 VGISYVVYENMKQTL 453
               + VY+  K  L
Sbjct: 188 RAAYFGVYDTAKGML 202


>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
          Length = 298

 Score =  131 bits (329), Expect = 1e-30
 Identities = 90/293 (30%), Positives = 152/293 (51%), Gaps = 24/293 (8%)

Query: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSK---SDKM--NIFGGFRQMVKEGGIRS 230
           +  LAGG+A A+S+T+ AP++R+K+++QV H SK   +DK    I     ++ KE G+ S
Sbjct: 10  KDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLS 69

Query: 231 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM-----AGATAQT 285
            WRGN  NVI+  P  A+ F   ++YK++      K   F  + +G++     AGAT+  
Sbjct: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLC 129

Query: 286 FIYPMEVMKTRLA--VGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAG 340
           F+YP++  +TRLA  VGK G   ++ G+ DC  KI K +G+   Y+G+  ++ GII Y  
Sbjct: 130 FVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRA 189

Query: 341 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 400
               +Y+  K         D  N  +++        +    L SYP   VR RM  Q+  
Sbjct: 190 AYFGIYDTAK-----GMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGR 244

Query: 401 EGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
           +G+  +    +  +R+I   EG    ++G   N ++ +    +  V+Y+ +K+
Sbjct: 245 KGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDEIKK 296



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 49/194 (25%), Positives = 86/194 (44%), Gaps = 16/194 (8%)

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAVGKTG-------QYSGIYDCAKKILKHEGLGAFY 325
           F++G +A A ++T + P+E +K  L V           QY GI DC  +I K +G+ +F+
Sbjct: 12  FLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFW 71

Query: 326 KGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDS----VNPGVMVLLGCGALSSTCGQ 381
           +G + N++   P   ++ A  +  K  +L    K +       G +   G    +S C  
Sbjct: 72  RGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLC-- 129

Query: 382 LASYPLALVRTRMQAQAMLEGSPQ--LNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAV 439
              YPL   RTR+ A     G+ +    +     +I   +GI GLY+G   +   ++   
Sbjct: 130 -FVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYR 188

Query: 440 GISYVVYENMKQTL 453
              + +Y+  K  L
Sbjct: 189 AAYFGIYDTAKGML 202


>gi|21687151 mitochondrial solute carrier protein [Homo sapiens]
          Length = 341

 Score =  127 bits (319), Expect = 2e-29
 Identities = 80/283 (28%), Positives = 145/283 (51%), Gaps = 12/283 (4%)

Query: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNG 236
           ++LL  G+AG +S + TAPL+   ++ QV   +      +    ++ +  G+R+LW+GN 
Sbjct: 14  QRLLCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGHRVWRAEGLRALWKGNA 73

Query: 237 TNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTR 296
              +++ P +AV+  AY ++  L T++   I  +   ++GS+AG  +    YP +++KTR
Sbjct: 74  VACLRLFPCSAVQLAAYRKFVVLFTDDLGHISQWSSIMAGSLAGMVSTIVTYPTDLIKTR 133

Query: 297 LAVGK--TGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWL 354
           L +       Y G+      I + EG  A Y+G    ++G +P++   L VY  L+  W 
Sbjct: 134 LIMQNILEPSYRGLLHAFSTIYQQEGFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIW- 192

Query: 355 DNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML---EGSPQLNMVG- 410
            N  +D  +        C  L++   Q  S+P   V+ +MQAQ+      G   ++  G 
Sbjct: 193 -NGPRDQFSLPQNFANVC--LAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGA 249

Query: 411 --LFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
              FR+I+  +G+ GL+ G+T N +K++P  GI +  +E  K+
Sbjct: 250 VDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKR 292



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 52/196 (26%), Positives = 88/196 (44%), Gaps = 11/196 (5%)

Query: 165 FTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHG-SKSDKMNIFGGFRQMV 223
           FT+D     QW   ++AG +AG VS   T P D +K  + +    +     +   F  + 
Sbjct: 97  FTDDLGHISQW-SSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPSYRGLLHAFSTIY 155

Query: 224 KEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATA 283
           ++ G  +L+RG    V+   P +A     Y   +K+      +    + F +  +A A  
Sbjct: 156 QQEGFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQFSLPQNFANVCLAAAVT 215

Query: 284 QTFIYPMEVMKTRLAV---------GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLG 334
           QT  +P E +K ++           G    +SG  DC ++I+K +G+   + G   NLL 
Sbjct: 216 QTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLK 275

Query: 335 IIPYAGIDLAVYELLK 350
           I+PY GI  + +E  K
Sbjct: 276 IVPYFGIMFSTFEFCK 291



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 8/84 (9%)

Query: 184 IAGAVSRTSTAPLDRLKIMMQVHGS---KSDKMNI-FGG----FRQMVKEGGIRSLWRGN 235
           +A AV++T + P + +K  MQ        S  +++ F G    FRQ+VK  G+  LW G 
Sbjct: 210 LAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGL 269

Query: 236 GTNVIKIAPETAVKFWAYEQYKKL 259
             N++KI P   + F  +E  K++
Sbjct: 270 TANLLKIVPYFGIMFSTFEFCKRI 293


>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
          Length = 315

 Score =  119 bits (297), Expect = 7e-27
 Identities = 86/290 (29%), Positives = 132/290 (45%), Gaps = 17/290 (5%)

Query: 176 WRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMV---KEGGIRSLW 232
           +  L+AG   G +S  +  PLD +KI   V      +    G    +    K  G+R L+
Sbjct: 23  YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82

Query: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTE-EGQKIGTFERFISGSMAGATAQTFIYPME 291
           +G   N+        + F+ Y   K   TE   +++   E  +S + AGA       P+ 
Sbjct: 83  QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142

Query: 292 VMKTRLAVGKTG-------QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLA 344
           V KTRL +           QY G++D   KI K+EG+   YKG+VP L G   +  +   
Sbjct: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201

Query: 345 VYELLKSYWLDNFAK-DSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGS 403
            YELLK  +  +  +        +  +   ALS      A+YP  +VR R+Q Q M    
Sbjct: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261

Query: 404 PQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
               ++ +  +   KEG+ G Y+GI PN ++V PA  I++VVYEN+   L
Sbjct: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 52/188 (27%), Positives = 88/188 (46%), Gaps = 13/188 (6%)

Query: 179 LLAGGIAGAVSRTSTAPL--DRLKIMMQ----VHGSKSDKMNIFGGFRQMVKEGGIRSLW 232
           L++   AGA++   T PL   + ++M+Q    V+        +F    ++ K  G+R L+
Sbjct: 124 LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLY 183

Query: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKI-----GTFERFISGSMAGATAQTFI 287
           +G    +   +   A++F AYE  K    +   ++      T E     +++   A    
Sbjct: 184 KGFVPGLFGTS-HGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAAT 242

Query: 288 YPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYE 347
           YP +V++ RL   +   YSG+ D   K  + EG+G FYKG  PNL+ + P   I   VYE
Sbjct: 243 YPYQVVRARLQ-DQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301

Query: 348 LLKSYWLD 355
            +  + LD
Sbjct: 302 NVSHFLLD 309


>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
          Length = 320

 Score =  109 bits (273), Expect = 5e-24
 Identities = 79/287 (27%), Positives = 136/287 (47%), Gaps = 21/287 (7%)

Query: 180 LAGGIAGAVSRTSTAPLDRLKIMMQVHG---SKSDKMNIFGGF----RQMVKEGGIRSLW 232
           +AG ++G V+R   +P D +KI  Q+     S+SD    + G     RQ+++E G  + W
Sbjct: 20  VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79

Query: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE---RFISGSMAGATAQTFIYP 289
           +G+    I      AV+F ++E   +L+   G      E    F+ G +A   A   ++P
Sbjct: 80  KGHVPAQILSIGYGAVQFLSFEMLTELV-HRGSVYDAREFSVHFVCGGLAACMATLTVHP 138

Query: 290 MEVMKTRLAV-GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 348
           ++V++TR A  G+   Y+ +      + + EG   FYKG  P L+ I PYAG+  + Y  
Sbjct: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSS 198

Query: 349 LKS-YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLN 407
           LK  Y     A+   N  +  LL CG+ +    +  +YPL L + R+Q            
Sbjct: 199 LKHLYKWAIPAEGKKNENLQNLL-CGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257

Query: 408 MVGLF-------RRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
            V  +       ++++ KEG  G ++G++P+ +K   + G  +  YE
Sbjct: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 53/201 (26%), Positives = 95/201 (47%), Gaps = 22/201 (10%)

Query: 263 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV--------GKTGQYSGIYDCAKK 314
           +G+    F+  ++GS++G   +  I P +V+K R  +          + +Y GI   +++
Sbjct: 9   DGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQ 68

Query: 315 ILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA 374
           IL+ EG  AF+KG+VP  +  I Y  +    +E+L          D+    V  +  CG 
Sbjct: 69  ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFV--CGG 126

Query: 375 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----NMVGLFRRIISKEGIPGLYRGIT 429
           L++    L  +P+ ++RTR  AQ    G P++     + VG   R    EG    Y+G+ 
Sbjct: 127 LAACMATLTVHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYR---SEGPQVFYKGLA 179

Query: 430 PNFMKVLPAVGISYVVYENMK 450
           P  + + P  G+ +  Y ++K
Sbjct: 180 PTLIAIFPYAGLQFSCYSSLK 200



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 169 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR-------- 220
           E K  +  + LL G  AG +S+T T PLD  K  +QV G +  +   FG  R        
Sbjct: 210 EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARA-AFGQVRRYKGLMDC 268

Query: 221 --QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYE 254
             Q++++ G    ++G   +++K A  T   F++YE
Sbjct: 269 AKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304


>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
          Length = 320

 Score =  109 bits (273), Expect = 5e-24
 Identities = 79/287 (27%), Positives = 136/287 (47%), Gaps = 21/287 (7%)

Query: 180 LAGGIAGAVSRTSTAPLDRLKIMMQVHG---SKSDKMNIFGGF----RQMVKEGGIRSLW 232
           +AG ++G V+R   +P D +KI  Q+     S+SD    + G     RQ+++E G  + W
Sbjct: 20  VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79

Query: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE---RFISGSMAGATAQTFIYP 289
           +G+    I      AV+F ++E   +L+   G      E    F+ G +A   A   ++P
Sbjct: 80  KGHVPAQILSIGYGAVQFLSFEMLTELV-HRGSVYDAREFSVHFVCGGLAACMATLTVHP 138

Query: 290 MEVMKTRLAV-GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 348
           ++V++TR A  G+   Y+ +      + + EG   FYKG  P L+ I PYAG+  + Y  
Sbjct: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSS 198

Query: 349 LKS-YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLN 407
           LK  Y     A+   N  +  LL CG+ +    +  +YPL L + R+Q            
Sbjct: 199 LKHLYKWAIPAEGKKNENLQNLL-CGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257

Query: 408 MVGLF-------RRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
            V  +       ++++ KEG  G ++G++P+ +K   + G  +  YE
Sbjct: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 53/201 (26%), Positives = 95/201 (47%), Gaps = 22/201 (10%)

Query: 263 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV--------GKTGQYSGIYDCAKK 314
           +G+    F+  ++GS++G   +  I P +V+K R  +          + +Y GI   +++
Sbjct: 9   DGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQ 68

Query: 315 ILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA 374
           IL+ EG  AF+KG+VP  +  I Y  +    +E+L          D+    V  +  CG 
Sbjct: 69  ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFV--CGG 126

Query: 375 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----NMVGLFRRIISKEGIPGLYRGIT 429
           L++    L  +P+ ++RTR  AQ    G P++     + VG   R    EG    Y+G+ 
Sbjct: 127 LAACMATLTVHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYR---SEGPQVFYKGLA 179

Query: 430 PNFMKVLPAVGISYVVYENMK 450
           P  + + P  G+ +  Y ++K
Sbjct: 180 PTLIAIFPYAGLQFSCYSSLK 200



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 169 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR-------- 220
           E K  +  + LL G  AG +S+T T PLD  K  +QV G +  +   FG  R        
Sbjct: 210 EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARA-AFGQVRRYKGLMDC 268

Query: 221 --QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYE 254
             Q++++ G    ++G   +++K A  T   F++YE
Sbjct: 269 AKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304


>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
          Length = 320

 Score =  109 bits (273), Expect = 5e-24
 Identities = 79/287 (27%), Positives = 136/287 (47%), Gaps = 21/287 (7%)

Query: 180 LAGGIAGAVSRTSTAPLDRLKIMMQVHG---SKSDKMNIFGGF----RQMVKEGGIRSLW 232
           +AG ++G V+R   +P D +KI  Q+     S+SD    + G     RQ+++E G  + W
Sbjct: 20  VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79

Query: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE---RFISGSMAGATAQTFIYP 289
           +G+    I      AV+F ++E   +L+   G      E    F+ G +A   A   ++P
Sbjct: 80  KGHVPAQILSIGYGAVQFLSFEMLTELV-HRGSVYDAREFSVHFVCGGLAACMATLTVHP 138

Query: 290 MEVMKTRLAV-GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 348
           ++V++TR A  G+   Y+ +      + + EG   FYKG  P L+ I PYAG+  + Y  
Sbjct: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSS 198

Query: 349 LKS-YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLN 407
           LK  Y     A+   N  +  LL CG+ +    +  +YPL L + R+Q            
Sbjct: 199 LKHLYKWAIPAEGKKNENLQNLL-CGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257

Query: 408 MVGLF-------RRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
            V  +       ++++ KEG  G ++G++P+ +K   + G  +  YE
Sbjct: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 53/201 (26%), Positives = 95/201 (47%), Gaps = 22/201 (10%)

Query: 263 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV--------GKTGQYSGIYDCAKK 314
           +G+    F+  ++GS++G   +  I P +V+K R  +          + +Y GI   +++
Sbjct: 9   DGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQ 68

Query: 315 ILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA 374
           IL+ EG  AF+KG+VP  +  I Y  +    +E+L          D+    V  +  CG 
Sbjct: 69  ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFV--CGG 126

Query: 375 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----NMVGLFRRIISKEGIPGLYRGIT 429
           L++    L  +P+ ++RTR  AQ    G P++     + VG   R    EG    Y+G+ 
Sbjct: 127 LAACMATLTVHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYR---SEGPQVFYKGLA 179

Query: 430 PNFMKVLPAVGISYVVYENMK 450
           P  + + P  G+ +  Y ++K
Sbjct: 180 PTLIAIFPYAGLQFSCYSSLK 200



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 169 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR-------- 220
           E K  +  + LL G  AG +S+T T PLD  K  +QV G +  +   FG  R        
Sbjct: 210 EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARA-AFGQVRRYKGLMDC 268

Query: 221 --QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYE 254
             Q++++ G    ++G   +++K A  T   F++YE
Sbjct: 269 AKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304


>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
           sapiens]
          Length = 311

 Score =  108 bits (270), Expect = 1e-23
 Identities = 82/299 (27%), Positives = 135/299 (45%), Gaps = 35/299 (11%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGS----KSDKMNIFGG--------------FR 220
           L AGG  G V    T PL+ +K  +Q           ++N   G               +
Sbjct: 10  LFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLK 69

Query: 221 QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAG 280
            ++++ G RSL+RG G N++ +AP  A+ F AY   K+ L +      T    IS +MAG
Sbjct: 70  VILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMAG 129

Query: 281 ATAQTFIYPMEVMKTRL---AVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIP 337
            TA T   P+ ++KTRL   A  +  +  G ++C +K+ + +GL  FY+G   +  GI  
Sbjct: 130 FTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISE 189

Query: 338 YAGIDLAVYELLKSYWLDNFAKDSVN---------PGVMVLLGCGALSSTCGQLASYPLA 388
              I   +YE +K   L+     ++             + ++   A S TC    +YP  
Sbjct: 190 TV-IHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTIAYPHE 248

Query: 389 LVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
           +VRTR++     EG+   +       ++ +EG   LYRG+T + ++ +P   I    YE
Sbjct: 249 VVRTRLRE----EGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYE 303



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 56/204 (27%), Positives = 88/204 (43%), Gaps = 24/204 (11%)

Query: 269 TFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQY-------------------SGIY 309
           T     +G   G        P+EV+KTRL       Y                    G  
Sbjct: 6   TLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPL 65

Query: 310 DCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVL 369
            C K IL+ EG  + ++G  PNL+G+ P   I  A Y   K    D F  DS      V 
Sbjct: 66  HCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDS----TQVH 121

Query: 370 LGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGIT 429
           +   A++      A+ P+ L++TR+Q  A   G  ++      R++   +G+ G YRG++
Sbjct: 122 MISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMS 181

Query: 430 PNFMKVLPAVGISYVVYENMKQTL 453
            ++  +   V I +V+YE++KQ L
Sbjct: 182 ASYAGISETV-IHFVIYESIKQKL 204



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 50/186 (26%), Positives = 89/186 (47%), Gaps = 17/186 (9%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSD--KMNIFGGFRQMVKEGGIRSLWRGNG 236
           +++  +AG  + T+T P+  +K  +Q+        +M  F   R++ +  G++  +RG  
Sbjct: 122 MISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMS 181

Query: 237 TNVIKIAPETAVKFWAYEQYKKLLTE---------EGQKIGTFERFISGSMAGAT----A 283
            +   I+ ET + F  YE  K+ L E         + + +     F+   +A AT    A
Sbjct: 182 ASYAGIS-ETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCA 240

Query: 284 QTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDL 343
            T  YP EV++TRL    T +Y   +     +++ EG G+ Y+G   +L+  IP   I +
Sbjct: 241 TTIAYPHEVVRTRLREEGT-KYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMM 299

Query: 344 AVYELL 349
           A YEL+
Sbjct: 300 ATYELV 305



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 2/94 (2%)

Query: 167 EDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEG 226
           E  K++  +   +LA   +   + T   P + ++  ++  G+K    + F     +V+E 
Sbjct: 218 ESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLREEGTKY--RSFFQTLSLLVQEE 275

Query: 227 GIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLL 260
           G  SL+RG  T++++  P TA+    YE    LL
Sbjct: 276 GYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLL 309


>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
           sapiens]
          Length = 310

 Score =  104 bits (260), Expect = 1e-22
 Identities = 82/299 (27%), Positives = 135/299 (45%), Gaps = 36/299 (12%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGS----KSDKMNIFGG--------------FR 220
           L AGG  G V    T PL+ +K  +Q           ++N   G               +
Sbjct: 10  LFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLK 69

Query: 221 QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAG 280
            ++++ G RSL+RG G N++ +AP  A+ F AY   K+ L +      T    IS +MAG
Sbjct: 70  VILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMAG 129

Query: 281 ATAQTFIYPMEVMKTRL---AVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIP 337
            TA T   P+ ++KTRL   A  +  +  G ++C +K+ + +GL  FY+G   +  GI  
Sbjct: 130 FTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISE 189

Query: 338 YAGIDLAVYELLKSYWLDNFAKDSVN---------PGVMVLLGCGALSSTCGQLASYPLA 388
              I   +YE +K   L+     ++             + ++   A S TC    +YP  
Sbjct: 190 TV-IHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTIAYP-H 247

Query: 389 LVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
           +VRTR++     EG+   +       ++ +EG   LYRG+T + ++ +P   I    YE
Sbjct: 248 VVRTRLRE----EGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYE 302



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 56/204 (27%), Positives = 88/204 (43%), Gaps = 24/204 (11%)

Query: 269 TFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQY-------------------SGIY 309
           T     +G   G        P+EV+KTRL       Y                    G  
Sbjct: 6   TLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPL 65

Query: 310 DCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVL 369
            C K IL+ EG  + ++G  PNL+G+ P   I  A Y   K    D F  DS      V 
Sbjct: 66  HCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDS----TQVH 121

Query: 370 LGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGIT 429
           +   A++      A+ P+ L++TR+Q  A   G  ++      R++   +G+ G YRG++
Sbjct: 122 MISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMS 181

Query: 430 PNFMKVLPAVGISYVVYENMKQTL 453
            ++  +   V I +V+YE++KQ L
Sbjct: 182 ASYAGISETV-IHFVIYESIKQKL 204



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 49/186 (26%), Positives = 88/186 (47%), Gaps = 18/186 (9%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSD--KMNIFGGFRQMVKEGGIRSLWRGNG 236
           +++  +AG  + T+T P+  +K  +Q+        +M  F   R++ +  G++  +RG  
Sbjct: 122 MISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMS 181

Query: 237 TNVIKIAPETAVKFWAYEQYKKLLTE---------EGQKIGTFERFISGSMAGAT----A 283
            +   I+ ET + F  YE  K+ L E         + + +     F+   +A AT    A
Sbjct: 182 ASYAGIS-ETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCA 240

Query: 284 QTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDL 343
            T  YP  V++TRL    T +Y   +     +++ EG G+ Y+G   +L+  IP   I +
Sbjct: 241 TTIAYP-HVVRTRLREEGT-KYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMM 298

Query: 344 AVYELL 349
           A YEL+
Sbjct: 299 ATYELV 304



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 3/94 (3%)

Query: 167 EDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEG 226
           E  K++  +   +LA   +   + T   P   ++  ++  G+K    + F     +V+E 
Sbjct: 218 ESVKEASDFVGMMLAAATSKTCATTIAYP-HVVRTRLREEGTKY--RSFFQTLSLLVQEE 274

Query: 227 GIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLL 260
           G  SL+RG  T++++  P TA+    YE    LL
Sbjct: 275 GYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLL 308


>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
           sapiens]
          Length = 325

 Score =  104 bits (260), Expect = 1e-22
 Identities = 77/296 (26%), Positives = 130/296 (43%), Gaps = 14/296 (4%)

Query: 166 TEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKM-------NIFGG 218
           T   + SG  W+  + GG+A  V+   T P+D  K  +QV G   D          +F  
Sbjct: 31  TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 90

Query: 219 FRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM 278
             ++ KE G+ +L+ G    +++ A    +K   Y+  K+L  E  +        I G +
Sbjct: 91  LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVV 150

Query: 279 AGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 338
           +G  + T   P +V+K R+    +     +      I + EG    ++G VP        
Sbjct: 151 SGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIV 210

Query: 339 AGIDLAVYELLKSYW-LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQ 397
            G++L VY++ K +  L     D++    +    CG      G LAS P+ +VRTRM  Q
Sbjct: 211 VGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMMNQ 266

Query: 398 AMLEGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
             + G   L    V    ++   EG   LY+G  PN++++ P   I ++ YE +K+
Sbjct: 267 RAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 322



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 56/189 (29%), Positives = 94/189 (49%), Gaps = 15/189 (7%)

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAVG--------KTGQYSGIYDCAKKILKHEGLGAF 324
           F+ G +A   A+   +P+++ KTRL V         K  +Y G++    +I K EG+ A 
Sbjct: 44  FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 103

Query: 325 YKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLAS 384
           Y G  P LL    Y  I + +Y+ LK  +++    ++    +++ + CG +S       +
Sbjct: 104 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET----LLINMICGVVSGVISSTIA 159

Query: 385 YPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYV 444
            P  +++ RMQAQ  L    Q +M+G F  I  +EG  GL+RG+ P   +    VG+   
Sbjct: 160 NPTDVLKIRMQAQGSLF---QGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 216

Query: 445 VYENMKQTL 453
           VY+  K+ L
Sbjct: 217 VYDITKKHL 225



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 21/81 (25%), Positives = 41/81 (50%), Gaps = 7/81 (8%)

Query: 183 GIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIF----GGFRQMVKEGGIRSLWRGNGTN 238
           G+AGA++     P+D ++  M    +    ++++     G  +M K  G  +L++G   N
Sbjct: 246 GLAGALASN---PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPN 302

Query: 239 VIKIAPETAVKFWAYEQYKKL 259
            +++ P   + F  YEQ K+L
Sbjct: 303 WLRLGPWNIIFFITYEQLKRL 323


>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
           sapiens]
          Length = 322

 Score =  104 bits (260), Expect = 1e-22
 Identities = 77/296 (26%), Positives = 130/296 (43%), Gaps = 14/296 (4%)

Query: 166 TEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKM-------NIFGG 218
           T   + SG  W+  + GG+A  V+   T P+D  K  +QV G   D          +F  
Sbjct: 28  TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87

Query: 219 FRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM 278
             ++ KE G+ +L+ G    +++ A    +K   Y+  K+L  E  +        I G +
Sbjct: 88  LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVV 147

Query: 279 AGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 338
           +G  + T   P +V+K R+    +     +      I + EG    ++G VP        
Sbjct: 148 SGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIV 207

Query: 339 AGIDLAVYELLKSYW-LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQ 397
            G++L VY++ K +  L     D++    +    CG      G LAS P+ +VRTRM  Q
Sbjct: 208 VGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMMNQ 263

Query: 398 AMLEGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
             + G   L    V    ++   EG   LY+G  PN++++ P   I ++ YE +K+
Sbjct: 264 RAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 56/189 (29%), Positives = 94/189 (49%), Gaps = 15/189 (7%)

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAVG--------KTGQYSGIYDCAKKILKHEGLGAF 324
           F+ G +A   A+   +P+++ KTRL V         K  +Y G++    +I K EG+ A 
Sbjct: 41  FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100

Query: 325 YKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLAS 384
           Y G  P LL    Y  I + +Y+ LK  +++    ++    +++ + CG +S       +
Sbjct: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET----LLINMICGVVSGVISSTIA 156

Query: 385 YPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYV 444
            P  +++ RMQAQ  L    Q +M+G F  I  +EG  GL+RG+ P   +    VG+   
Sbjct: 157 NPTDVLKIRMQAQGSLF---QGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 213

Query: 445 VYENMKQTL 453
           VY+  K+ L
Sbjct: 214 VYDITKKHL 222



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 21/81 (25%), Positives = 41/81 (50%), Gaps = 7/81 (8%)

Query: 183 GIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIF----GGFRQMVKEGGIRSLWRGNGTN 238
           G+AGA++     P+D ++  M    +    ++++     G  +M K  G  +L++G   N
Sbjct: 243 GLAGALASN---PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPN 299

Query: 239 VIKIAPETAVKFWAYEQYKKL 259
            +++ P   + F  YEQ K+L
Sbjct: 300 WLRLGPWNIIFFITYEQLKRL 320


>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
          Length = 678

 Score =  102 bits (254), Expect = 7e-22
 Identities = 63/183 (34%), Positives = 99/183 (54%), Gaps = 5/183 (2%)

Query: 178 QLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGT 237
           ++LAGG AG      T PL+ +KI +QV G  +    +      ++++ GI  L++G   
Sbjct: 429 EVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA--LNVLRDLGIFGLYKGAKA 486

Query: 238 NVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRL 297
             ++  P +A+ F  Y   K LL +E   +G      +G+MAG  A + + P +V+KTRL
Sbjct: 487 CFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRL 546

Query: 298 AVG-KTGQ--YSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWL 354
            V  + GQ  YSG+ DC +KIL+ EG  AF+KG    +    P  G+ L  YELL+ ++ 
Sbjct: 547 QVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFY 606

Query: 355 DNF 357
            +F
Sbjct: 607 IDF 609



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 72/277 (25%), Positives = 126/277 (45%), Gaps = 13/277 (4%)

Query: 182 GGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKM------NIFGGFRQMVKEGGIRSLWRGN 235
           G +AGAV  T+  P+D +K  MQ        +      N F  F+++++  G   L+RG 
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392

Query: 236 GTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKT 295
              +I +APE A+K    +  +   T     +      ++G  AG +   F  P+E++K 
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKI 452

Query: 296 RLAVGKTGQY-SGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWL 354
           RL V   G+  +G    A  +L+  G+   YKG     L  IP++ I   VY   K    
Sbjct: 453 RLQV--AGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLL-- 508

Query: 355 DNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRR 414
              A ++ + G + LL  GA++         P  +++TR+Q  A    +    ++  FR+
Sbjct: 509 --LADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 566

Query: 415 IISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
           I+ +EG    ++G      +  P  G++ V YE +++
Sbjct: 567 ILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 58/193 (30%), Positives = 99/193 (51%), Gaps = 23/193 (11%)

Query: 272 RFISGSMAGATAQTFIYPMEVMKTRL--------AVGKTGQYSGIYDCAKKILKHEGLGA 323
           RF  GS+AGA   T +YP++++KTR+         VG+   Y   +DC KK+L++EG   
Sbjct: 329 RFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGEL-MYKNSFDCFKKVLRYEGFFG 387

Query: 324 FYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVN---PGVMVLLGCGALSSTCG 380
            Y+G +P L+G+ P   I L V + ++    D F +   +   P  ++  GC   S    
Sbjct: 388 LYRGLIPQLIGVAPEKAIKLTVNDFVR----DKFTRRDGSVPLPAEVLAGGCAGGSQV-- 441

Query: 381 QLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVG 440
            + + PL +V+ R+Q    +   P+++ + + R +    GI GLY+G    F++ +P   
Sbjct: 442 -IFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDL----GIFGLYKGAKACFLRDIPFSA 496

Query: 441 ISYVVYENMKQTL 453
           I + VY + K  L
Sbjct: 497 IYFPVYAHCKLLL 509


>gi|46094065 mitochondrial carrier family protein [Homo sapiens]
          Length = 338

 Score =  100 bits (249), Expect = 3e-21
 Identities = 75/309 (24%), Positives = 136/309 (44%), Gaps = 41/309 (13%)

Query: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIF---------------GG--- 218
           +Q+LA      ++     PLD +KI +Q   +   K   F               GG   
Sbjct: 17  QQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKL 76

Query: 219 --------------FRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEG 264
                         F ++++  GI+SLW G    ++   P T + F  Y+Q   LL  + 
Sbjct: 77  WYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKL 136

Query: 265 QKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAF 324
            +  T    ++G +A   A T I P+E+++T++   K   Y  ++    K +  +G  + 
Sbjct: 137 GENETCIPIVAGIVARFGAVTVISPLELIRTKMQ-SKKFSYVELHRFVSKKVSEDGWISL 195

Query: 325 YKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLAS 384
           ++G+ P +L  +P++ +    YE+LK +  +        P  M+    GALS +   +A+
Sbjct: 196 WRGWAPTVLRDVPFSAMYWYNYEILKKWLCEK--SGLYEPTFMINFTSGALSGSFAAVAT 253

Query: 385 YPLALVRTRMQAQAMLEGSPQLNMV------GLFRRIISKEGIPGLYRGITPNFMKVLPA 438
            P  +V+T+ Q Q     S +++M        + + I++K G  GL+ G+ P  +K+ PA
Sbjct: 254 LPFDVVKTQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIKIAPA 313

Query: 439 VGISYVVYE 447
             I    YE
Sbjct: 314 CAIMISTYE 322



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 51/188 (27%), Positives = 85/188 (45%), Gaps = 23/188 (12%)

Query: 184 IAGAVSR----TSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNV 239
           +AG V+R    T  +PL+ ++  MQ    K   + +     + V E G  SLWRG    V
Sbjct: 146 VAGIVARFGAVTVISPLELIRTKMQ--SKKFSYVELHRFVSKKVSEDGWISLWRGWAPTV 203

Query: 240 IKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE-----RFISGSMAGATAQTFIYPMEVMK 294
           ++  P +A+ ++ YE  KK L E   K G +E      F SG+++G+ A     P +V+K
Sbjct: 204 LRDVPFSAMYWYNYEILKKWLCE---KSGLYEPTFMINFTSGALSGSFAAVATLPFDVVK 260

Query: 295 TRLAVG---------KTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAV 345
           T+                 +   +   K I+   G    + G +P L+ I P   I ++ 
Sbjct: 261 TQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIKIAPACAIMIST 320

Query: 346 YELLKSYW 353
           YE  K+++
Sbjct: 321 YEFGKAFF 328



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 43/160 (26%), Positives = 75/160 (46%), Gaps = 22/160 (13%)

Query: 301 KTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYE----LLKSYWLDN 356
           K G + G  D   KI+++EG+ + + G  P L+  +P   I    Y+    LL+S   +N
Sbjct: 80  KPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKLGEN 139

Query: 357 FAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRI- 415
                +  G++   G   + S        PL L+RT+MQ       S + + V L R + 
Sbjct: 140 ETCIPIVAGIVARFGAVTVIS--------PLELIRTKMQ-------SKKFSYVELHRFVS 184

Query: 416 --ISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
             +S++G   L+RG  P  ++ +P   + +  YE +K+ L
Sbjct: 185 KKVSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWL 224


>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
          Length = 291

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 73/287 (25%), Positives = 124/287 (43%), Gaps = 15/287 (5%)

Query: 176 WRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMV-------KEGGI 228
           W+  + GG+A   +   T P+D  K  +Q+ G  +D       +R M+       +E G+
Sbjct: 6   WKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGL 65

Query: 229 RSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIY 288
           ++L+ G    +++ A    +K   Y+  K+L  E  +        I G ++G  + T   
Sbjct: 66  KALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIAN 125

Query: 289 PMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 348
           P +V+K R+         G+      I + EG    +KG            G++L VY++
Sbjct: 126 PTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDI 185

Query: 349 LKSYW-LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLN 407
            K +  L     D+V    +    CG      G LAS P+ +VRTRM  Q +L       
Sbjct: 186 TKKHLILSGLMGDTVYTHFLSSFTCG----LAGALASNPVDVVRTRMMNQRVLRDGRCSG 241

Query: 408 MVGLFRRII---SKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
             G    ++     EG   LY+G  PN++++ P   I +V YE +K+
Sbjct: 242 YTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 55/189 (29%), Positives = 94/189 (49%), Gaps = 15/189 (7%)

Query: 273 FISGSMAGATAQTFIYPMEVMKTRLAV-GKTG-------QYSGIYDCAKKILKHEGLGAF 324
           F+ G +A  TA+   +P+++ KTRL + G+T        +Y G+     +I + EGL A 
Sbjct: 9   FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKAL 68

Query: 325 YKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLAS 384
           Y G  P +L    Y  I +  Y+ LK  +++    +++   V+    CG LS       +
Sbjct: 69  YSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVI----CGILSGVISSTIA 124

Query: 385 YPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYV 444
            P  +++ RMQAQ+    + Q  M+G F  I  +EG  GL++G++    +    VG+   
Sbjct: 125 NPTDVLKIRMQAQS---NTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELP 181

Query: 445 VYENMKQTL 453
           VY+  K+ L
Sbjct: 182 VYDITKKHL 190


>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
          Length = 338

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 79/289 (27%), Positives = 128/289 (44%), Gaps = 24/289 (8%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGS--KSDKMNIFGGFRQMVKEGGIRSLWRGNG 236
           + AG +AG +  +   P+D +K  MQ      K+   +I+G  +++++  G     RG  
Sbjct: 49  MTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVN 108

Query: 237 TNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGT--FERFISGSMAGATAQTFIYPMEVMK 294
             ++   P  A+ F  YE  K+ L +     G       I+GSMA       + P EV+K
Sbjct: 109 VMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVK 168

Query: 295 TRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWL 354
            RL +  +   S I  C + + + EGLGAFY+ Y   L   IP+  I    YE       
Sbjct: 169 QRLQMYNSQHRSAI-SCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYE------- 220

Query: 355 DNFAKDSVNP----GVMVLLGCGALSSTCGQLASYPLALVRTRMQAQ-----AMLEGSPQ 405
             F ++ VNP         +  G L+      A+ PL + +T +  Q     ++   S +
Sbjct: 221 --FLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGR 278

Query: 406 LN-MVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
           L+ M   FR +    G+ G ++GI    +  +P+  IS+ VYE  K  L
Sbjct: 279 LSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFL 327



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 8/92 (8%)

Query: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKM-NIFG-------GFRQMVKEGGIRS 230
           +++GG+AGA++  +T PLD  K ++    + +  + NI G        FR + +  G+  
Sbjct: 238 IISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAG 297

Query: 231 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTE 262
            ++G    VI   P TA+ +  YE +K  LT+
Sbjct: 298 YFKGIQARVIYQMPSTAISWSVYEFFKYFLTK 329


>gi|7706306 solute carrier family 25, member 39 isoform b [Homo
           sapiens]
          Length = 351

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 65/236 (27%), Positives = 112/236 (47%), Gaps = 11/236 (4%)

Query: 219 FRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM 278
           F ++V+  G R+LW G    ++   P TA+ F AY+Q K  L         +   ++G++
Sbjct: 103 FVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGAL 162

Query: 279 AGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 338
           A     T I P+E+M+T+L       Y  +  C +  +   G  + + G+ P  L  +P+
Sbjct: 163 ARLGTVTVISPLELMRTKLQAQHV-SYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPF 221

Query: 339 AGIDLAVYELLKSYWLDNF-AKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQ 397
           + +    YEL+KS WL+ F  KD  + G+  +   G +S T   + + P  +V+T+ Q  
Sbjct: 222 SALYWFNYELVKS-WLNGFRPKDQTSVGMSFV--AGGISGTVAAVLTLPFDVVKTQRQVA 278

Query: 398 AMLEGSPQLNMVG------LFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
                + ++N +       L RRI ++ G  GL+ G  P  +K  P+  I    YE
Sbjct: 279 LGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYE 334



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 47/190 (24%), Positives = 84/190 (44%), Gaps = 17/190 (8%)

Query: 179 LLAGGIAGAVSRTST----APLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRG 234
           L A  +AGA++R  T    +PL+ ++  +Q       ++      R  V +GG RSLW G
Sbjct: 153 LYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGAC--VRTAVAQGGWRSLWLG 210

Query: 235 NGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE--RFISGSMAGATAQTFIYPMEV 292
            G   ++  P +A+ ++ YE  K  L     K  T     F++G ++G  A     P +V
Sbjct: 211 WGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDV 270

Query: 293 MKTRLAVGKTGQYS---------GIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDL 343
           +KT+  V      +           +   ++I    G    + G++P ++   P   I +
Sbjct: 271 VKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMI 330

Query: 344 AVYELLKSYW 353
           + YE  KS++
Sbjct: 331 STYEFGKSFF 340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,686,342
Number of Sequences: 37866
Number of extensions: 667250
Number of successful extensions: 3014
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 1876
Number of HSP's gapped (non-prelim): 644
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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