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Search of human proteins with 47419936
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47419936 SFRS protein kinase 1 [Homo sapiens]
(655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47419936 SFRS protein kinase 1 [Homo sapiens] 1333 0.0
gi|33188449 serine/arginine-rich protein-specific kinase 2 isofo... 781 0.0
gi|33188447 serine/arginine-rich protein-specific kinase 2 isofo... 766 0.0
gi|63025196 serine arginine rich protein-specific kinase 3 [Homo... 404 e-112
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 102 1e-21
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 102 1e-21
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 100 7e-21
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 100 7e-21
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 98 2e-20
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 98 2e-20
gi|47717134 CDC-like kinase 2 [Homo sapiens] 97 6e-20
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 95 2e-19
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 95 2e-19
gi|10190706 CDC-like kinase 4 [Homo sapiens] 92 1e-18
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 86 8e-17
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 86 1e-16
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 86 1e-16
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 86 1e-16
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 85 2e-16
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 85 2e-16
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 85 2e-16
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 85 2e-16
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 85 2e-16
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 80 8e-15
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 72 2e-12
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 72 2e-12
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 70 8e-12
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 70 8e-12
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 70 8e-12
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 69 1e-11
>gi|47419936 SFRS protein kinase 1 [Homo sapiens]
Length = 655
Score = 1333 bits (3449), Expect = 0.0
Identities = 655/655 (100%), Positives = 655/655 (100%)
Query: 1 MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN 60
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
Sbjct: 1 MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN 60
Query: 61 DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET 120
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
Sbjct: 61 DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET 120
Query: 121 ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN 180
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
Sbjct: 121 ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN 180
Query: 181 YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR 240
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
Sbjct: 181 YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR 240
Query: 241 SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ 300
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
Sbjct: 241 SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ 300
Query: 301 KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI 360
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
Sbjct: 301 KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI 360
Query: 361 EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE 420
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
Sbjct: 361 EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE 420
Query: 421 VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV 480
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
Sbjct: 421 VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV 480
Query: 481 NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM 540
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
Sbjct: 481 NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM 540
Query: 541 AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI 600
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
Sbjct: 541 AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI 600
Query: 601 TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 655
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
Sbjct: 601 TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 655
>gi|33188449 serine/arginine-rich protein-specific kinase 2 isoform
a [Homo sapiens]
Length = 699
Score = 781 bits (2017), Expect = 0.0
Identities = 413/709 (58%), Positives = 501/709 (70%), Gaps = 69/709 (9%)
Query: 3 RKVLALQARKKRTKAKKDKAQRKSETQHRGSA-------------PHSESDLPEQEEEIL 49
RKVLA+QARK+R K ++K +K E Q + P + PE EEEIL
Sbjct: 4 RKVLAIQARKRRPK--REKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEIL 61
Query: 50 GSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMK 109
GSDD+EQEDP DYCKGGYH VKIGDLFNGRYHVIRKLGWGHFSTVWL WD+QGK+FVAMK
Sbjct: 62 GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMK 121
Query: 110 VVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLG 169
VVKSA+HYTETALDEI+LLK VR SDP+DPN++MVVQL+DDFKISG+NG H+CMVFEVLG
Sbjct: 122 VVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLG 181
Query: 170 HHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIR 229
HHLLKWIIKSNYQGLP+ CVK II+QVLQGLDYLH+KC+IIHTDIKPENIL+ V++ Y+R
Sbjct: 182 HHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVR 241
Query: 230 RLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEI 289
R+AAEATEWQ++GAPPPSGSAVSTAPQ KP K+SKNKKKKLKKKQKRQAELLEKR+QEI
Sbjct: 242 RMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEI 301
Query: 290 EEMEKES-------GPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQ-- 340
EE+E+E+ P+ ++ E E LK + + + + + +DQ
Sbjct: 302 EELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEE 361
Query: 341 ------TLMERDTEGGAAEI-----------NCNGVIE--VINYTQNSNNETLRHKEDLH 381
+E+D + E+ NG IE + Q ++E +ED
Sbjct: 362 KEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDED-DDEEDCP 420
Query: 382 NANDCDVQNLNQESSFLSSQ-----NGDSST-------SQETDSCTPITSEVSDTMVCQS 429
N + ++ N ES + S NG+ SQ + T + S + + C S
Sbjct: 421 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 480
Query: 430 SSTVGQSFSEQHISQLQESIRAEIPCEDEQ---EQEHNGPLDNKGKSTAGNFLVNPLEPK 486
+ G +EQ S P D G L K K+ A + LVNPL+P+
Sbjct: 481 VLSEGSPLTEQEESS---------PSHDRSRTVSASSTGDLP-KAKTRAADLLVNPLDPR 530
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
NA+K++VKIADLGNACWVHKHFTEDIQTRQYRS+EVLIG+GY+TPADIWSTACMAFELAT
Sbjct: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPW 606
GDYLFEPHSGE+Y+RDEDHIA IIELLG +PR ++GKYS+EFF ++G+L+HITKLKPW
Sbjct: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPW 650
Query: 607 GLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 655
LF+VLVEKY W E+AA FTDFL+PMLE++PEKRA+A ECLRHPWLNS
Sbjct: 651 SLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 699
>gi|33188447 serine/arginine-rich protein-specific kinase 2 isoform
b [Homo sapiens]
Length = 688
Score = 766 bits (1979), Expect = 0.0
Identities = 397/657 (60%), Positives = 478/657 (72%), Gaps = 54/657 (8%)
Query: 42 PEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQ 101
PE EEEILGSDD+EQEDP DYCKGGYH VKIGDLFNGRYHVIRKLGWGHFSTVWL WD+Q
Sbjct: 43 PEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ 102
Query: 102 GKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHI 161
GK+FVAMKVVKSA+HYTETALDEI+LLK VR SDP+DPN++MVVQL+DDFKISG+NG H+
Sbjct: 103 GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV 162
Query: 162 CMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
CMVFEVLGHHLLKWIIKSNYQGLP+ CVK II+QVLQGLDYLH+KC+IIHTDIKPENIL+
Sbjct: 163 CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
Query: 222 SVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAEL 281
V++ Y+RR+AAEATEWQ++GAPPPSGSAVSTAPQ KP K+SKNKKKKLKKKQKRQAEL
Sbjct: 223 CVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAEL 282
Query: 282 LEKRMQEIEEMEKES-------GPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESS 334
LEKR+QEIEE+E+E+ P+ ++ E E LK + + + + +
Sbjct: 283 LEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDN 342
Query: 335 TIGQDQ--------TLMERDTEGGAAEI-----------NCNGVIE--VINYTQNSNNET 373
+DQ +E+D + E+ NG IE + Q ++E
Sbjct: 343 GEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDED 402
Query: 374 LRHKEDLHNANDCDVQNLNQESSFLSSQ-----NGDSST-------SQETDSCTPITSEV 421
+ED N + ++ N ES + S NG+ SQ + T + S
Sbjct: 403 -DDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGS 461
Query: 422 SDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQ---EQEHNGPLDNKGKSTAGNF 478
+ + C S + G +EQ S P D G L K K+ A +
Sbjct: 462 LEPVACGSVLSEGSPLTEQEESS---------PSHDRSRTVSASSTGDLP-KAKTRAADL 511
Query: 479 LVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTA 538
LVNPL+P+NA+K++VKIADLGNACWVHKHFTEDIQTRQYRS+EVLIG+GY+TPADIWSTA
Sbjct: 512 LVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTA 571
Query: 539 CMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLK 598
CMAFELATGDYLFEPHSGE+Y+RDEDHIA IIELLG +PR ++GKYS+EFF ++G+L+
Sbjct: 572 CMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELR 631
Query: 599 HITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 655
HITKLKPW LF+VLVEKY W E+AA FTDFL+PMLE++PEKRA+A ECLRHPWLNS
Sbjct: 632 HITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 688
>gi|63025196 serine arginine rich protein-specific kinase 3 [Homo
sapiens]
Length = 567
Score = 404 bits (1039), Expect = e-112
Identities = 189/273 (69%), Positives = 230/273 (84%), Gaps = 1/273 (0%)
Query: 22 AQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYH 81
+Q + GS + +P+ + +LGSDD+EQEDP DYCKGGYH VKIGD+FNGRYH
Sbjct: 21 SQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYH 80
Query: 82 VIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNR 141
V+RKLGWGHFSTVWL WDIQ K+FVA+KVVKSA HYTETA+DEI+LLK VR+SDP+DP R
Sbjct: 81 VVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKR 140
Query: 142 EMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLD 201
E +VQL+DDF+ISGVNG H+CMV EVLGH LLKWIIKSNYQGLP+PCVK I++QVL GLD
Sbjct: 141 ETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLD 200
Query: 202 YLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQP-KPA 260
YLHTKC+IIHTDIKPENILL V + YIRRLAAEATEWQ++GAPPPS S VSTAPQ
Sbjct: 201 YLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQT 260
Query: 261 DKMSKNKKKKLKKKQKRQAELLEKRMQEIEEME 293
K+SKNK+KK+++K+K+Q LLE+R+++++ +E
Sbjct: 261 GKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLE 293
Score = 298 bits (762), Expect = 1e-80
Identities = 151/267 (56%), Positives = 187/267 (70%), Gaps = 8/267 (2%)
Query: 394 ESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVG-QSFSE-QHISQLQESIRA 451
E S L G STS + C P + + S + G +S S S S+ +
Sbjct: 302 EDSGLRLDGGSGSTS--SSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFS 359
Query: 452 EIPCE----DEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH 507
C ++E G L A N LVNPLEP+NA+K+K+KIADLGNACWVHKH
Sbjct: 360 PASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKH 419
Query: 508 FTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIA 567
FTEDIQTRQYR++EVLIG+ Y PADIWSTACMAFELATGDYLFEPHSGE+Y+RDEDHIA
Sbjct: 420 FTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA 479
Query: 568 LIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFT 627
I+ELLG +P ++G+YS+EFF ++G+L+HI LK WGL+EVL+EKYEW E+A F+
Sbjct: 480 HIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFS 539
Query: 628 DFLLPMLELIPEKRATAAECLRHPWLN 654
FLLPM+E IPEKRA+AA+CL+HPWLN
Sbjct: 540 AFLLPMMEYIPEKRASAADCLQHPWLN 566
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 102 bits (253), Expect = 1e-21
Identities = 58/143 (40%), Positives = 88/143 (61%), Gaps = 7/143 (4%)
Query: 79 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 138
RY V++ +G G F V ++D + + VA+K+V++ + + A +EIR+L+ +R D +
Sbjct: 221 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD- 279
Query: 139 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 198
N V+ +L++F HICM FE+L +L + I K+ +QG LP V+K +LQ
Sbjct: 280 -NTMNVIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 334
Query: 199 GLDYLHTKCRIIHTDIKPENILL 221
LD LH K RIIH D+KPENILL
Sbjct: 335 CLDALH-KNRIIHCDLKPENILL 356
Score = 91.3 bits (225), Expect = 3e-18
Identities = 62/178 (34%), Positives = 88/178 (49%), Gaps = 23/178 (12%)
Query: 493 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE 552
+K+ D G++C+ H+ IQ+R YR+ EV++G+ Y P D+WS C+ EL TG L
Sbjct: 364 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLL- 422
Query: 553 PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKH--ITKLKPW---- 606
GE+ + D +A +IELLG +KL+ A K +K F + KG ++ +T L
Sbjct: 423 --PGED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVL 477
Query: 607 -------GLFEVLVEKYEWSQE----EAAGFTDFLLPMLELIPEKRATAAECLRHPWL 653
G E EW + F DFL LE P R T + LRHPWL
Sbjct: 478 NGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 535
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 102 bits (253), Expect = 1e-21
Identities = 58/143 (40%), Positives = 88/143 (61%), Gaps = 7/143 (4%)
Query: 79 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 138
RY V++ +G G F V ++D + + VA+K+V++ + + A +EIR+L+ +R D +
Sbjct: 148 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD- 206
Query: 139 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 198
N V+ +L++F HICM FE+L +L + I K+ +QG LP V+K +LQ
Sbjct: 207 -NTMNVIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 261
Query: 199 GLDYLHTKCRIIHTDIKPENILL 221
LD LH K RIIH D+KPENILL
Sbjct: 262 CLDALH-KNRIIHCDLKPENILL 283
Score = 91.3 bits (225), Expect = 3e-18
Identities = 62/178 (34%), Positives = 88/178 (49%), Gaps = 23/178 (12%)
Query: 493 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE 552
+K+ D G++C+ H+ IQ+R YR+ EV++G+ Y P D+WS C+ EL TG L
Sbjct: 291 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLL- 349
Query: 553 PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKH--ITKLKPW---- 606
GE+ + D +A +IELLG +KL+ A K +K F + KG ++ +T L
Sbjct: 350 --PGED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVL 404
Query: 607 -------GLFEVLVEKYEWSQE----EAAGFTDFLLPMLELIPEKRATAAECLRHPWL 653
G E EW + F DFL LE P R T + LRHPWL
Sbjct: 405 NGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 99.8 bits (247), Expect = 7e-21
Identities = 64/213 (30%), Positives = 114/213 (53%), Gaps = 16/213 (7%)
Query: 9 QARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYH 68
Q ++ + ++ KS+ + S H S + S +D++E G+
Sbjct: 140 QNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEE--------GHL 191
Query: 69 LVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQ-GKKFVAMKVVKSAEHYTETALDEIRL 127
+ + GD+ + RY ++ LG G F V D + G + VA+K+VK+ + Y E A EI++
Sbjct: 192 ICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQV 251
Query: 128 LKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLP 187
L+ + +DPN R VQ+L+ F+ G HIC+VFE+LG +I ++ + L
Sbjct: 252 LEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGLSTYDFIKENGFLPFRLD 305
Query: 188 CVKKIIQQVLQGLDYLHTKCRIIHTDIKPENIL 220
++K+ Q+ + +++LH+ ++ HTD+KPENIL
Sbjct: 306 HIRKMAYQICKSVNFLHSN-KLTHTDLKPENIL 337
Score = 77.0 bits (188), Expect = 5e-14
Identities = 47/164 (28%), Positives = 84/164 (51%), Gaps = 8/164 (4%)
Query: 493 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE 552
+K+ D G+A + +H + + TR YR+ EV++ G++ P D+WS C+ E G +F
Sbjct: 363 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 422
Query: 553 PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL-KHITKLKPWGLFEV 611
H +E H+A++ +LG +P+ +I + K F + D +H + +
Sbjct: 423 THDSKE------HLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCK 476
Query: 612 LVEKYEWSQE-EAAGFTDFLLPMLELIPEKRATAAECLRHPWLN 654
++++ SQ+ E D + MLE P KR T E L+HP+ +
Sbjct: 477 PLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 520
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 99.8 bits (247), Expect = 7e-21
Identities = 64/213 (30%), Positives = 114/213 (53%), Gaps = 16/213 (7%)
Query: 9 QARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYH 68
Q ++ + ++ KS+ + S H S + S +D++E G+
Sbjct: 98 QNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEE--------GHL 149
Query: 69 LVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQ-GKKFVAMKVVKSAEHYTETALDEIRL 127
+ + GD+ + RY ++ LG G F V D + G + VA+K+VK+ + Y E A EI++
Sbjct: 150 ICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQV 209
Query: 128 LKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLP 187
L+ + +DPN R VQ+L+ F+ G HIC+VFE+LG +I ++ + L
Sbjct: 210 LEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGLSTYDFIKENGFLPFRLD 263
Query: 188 CVKKIIQQVLQGLDYLHTKCRIIHTDIKPENIL 220
++K+ Q+ + +++LH+ ++ HTD+KPENIL
Sbjct: 264 HIRKMAYQICKSVNFLHSN-KLTHTDLKPENIL 295
Score = 77.0 bits (188), Expect = 5e-14
Identities = 47/164 (28%), Positives = 84/164 (51%), Gaps = 8/164 (4%)
Query: 493 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE 552
+K+ D G+A + +H + + TR YR+ EV++ G++ P D+WS C+ E G +F
Sbjct: 321 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 380
Query: 553 PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL-KHITKLKPWGLFEV 611
H +E H+A++ +LG +P+ +I + K F + D +H + +
Sbjct: 381 THDSKE------HLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCK 434
Query: 612 LVEKYEWSQE-EAAGFTDFLLPMLELIPEKRATAAECLRHPWLN 654
++++ SQ+ E D + MLE P KR T E L+HP+ +
Sbjct: 435 PLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 478
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 98.2 bits (243), Expect = 2e-20
Identities = 67/222 (30%), Positives = 112/222 (50%), Gaps = 33/222 (14%)
Query: 7 ALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGG 66
A K+RT++ + R ++ R S S +D++E G
Sbjct: 255 AHHCHKRRTRSCSSASSRSQQSSKRSSR----------------SVEDDKE--------G 290
Query: 67 YHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWD-IQGKKFVAMKVVKSAEHYTETALDEI 125
+ + +IGD RY ++ LG G F V D +GK VA+K++++ Y E A EI
Sbjct: 291 HLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEI 350
Query: 126 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLP 185
+LK ++ D N+ + V + D F G H+C+ FE+LG + +++ ++N+Q P
Sbjct: 351 NVLKKIKEKDKE--NKFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQPYP 404
Query: 186 LPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQY 227
LP V+ + Q+ L +LH ++ HTD+KPENIL VN ++
Sbjct: 405 LPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENILF-VNSEF 444
Score = 84.3 bits (207), Expect = 3e-16
Identities = 55/182 (30%), Positives = 86/182 (47%), Gaps = 30/182 (16%)
Query: 484 EPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFE 543
E K+ + +++AD G+A + H+H T + TR YR EV++ G+ P D+WS C+ FE
Sbjct: 455 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 514
Query: 544 LATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL------ 597
G LF+ H E H+ ++ ++LG +P +I + K F+ KG L
Sbjct: 515 YYRGFTLFQTHENRE------HLVMMEKILGPIPSHMIHRTRKQKYFY--KGGLVWDENS 566
Query: 598 -------KHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRH 650
++ LK + L + L E D + MLE P +R T AE L H
Sbjct: 567 SDGRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLH 617
Query: 651 PW 652
P+
Sbjct: 618 PF 619
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 98.2 bits (243), Expect = 2e-20
Identities = 67/222 (30%), Positives = 112/222 (50%), Gaps = 33/222 (14%)
Query: 7 ALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGG 66
A K+RT++ + R ++ R S S +D++E G
Sbjct: 107 AHHCHKRRTRSCSSASSRSQQSSKRSSR----------------SVEDDKE--------G 142
Query: 67 YHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWD-IQGKKFVAMKVVKSAEHYTETALDEI 125
+ + +IGD RY ++ LG G F V D +GK VA+K++++ Y E A EI
Sbjct: 143 HLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEI 202
Query: 126 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLP 185
+LK ++ D N+ + V + D F G H+C+ FE+LG + +++ ++N+Q P
Sbjct: 203 NVLKKIKEKDKE--NKFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQPYP 256
Query: 186 LPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQY 227
LP V+ + Q+ L +LH ++ HTD+KPENIL VN ++
Sbjct: 257 LPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENILF-VNSEF 296
Score = 84.3 bits (207), Expect = 3e-16
Identities = 55/182 (30%), Positives = 86/182 (47%), Gaps = 30/182 (16%)
Query: 484 EPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFE 543
E K+ + +++AD G+A + H+H T + TR YR EV++ G+ P D+WS C+ FE
Sbjct: 307 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 366
Query: 544 LATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL------ 597
G LF+ H E H+ ++ ++LG +P +I + K F+ KG L
Sbjct: 367 YYRGFTLFQTHENRE------HLVMMEKILGPIPSHMIHRTRKQKYFY--KGGLVWDENS 418
Query: 598 -------KHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRH 650
++ LK + L + L E D + MLE P +R T AE L H
Sbjct: 419 SDGRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLH 469
Query: 651 PW 652
P+
Sbjct: 470 PF 471
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 96.7 bits (239), Expect = 6e-20
Identities = 68/218 (31%), Positives = 107/218 (49%), Gaps = 25/218 (11%)
Query: 11 RKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLV 70
R +R+ +K + +R+ S+ HS E DD E G+ +
Sbjct: 109 RSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVE------DDAE----------GHLIY 152
Query: 71 KIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQ-GKKFVAMKVVKSAEHYTETALDEIRLLK 129
+GD RY ++ LG G F V D + G VA+K++K+ E Y E A EI +L+
Sbjct: 153 HVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLE 212
Query: 130 SVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCV 189
+ DP+ N+ + VQ+ D F G H+C+ FE+LG ++ +NY P+ V
Sbjct: 213 KINEKDPD--NKNLCVQMFDWFDYHG----HMCISFELLGLSTFDFLKDNNYLPYPIHQV 266
Query: 190 KKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQY 227
+ + Q+ Q + +LH ++ HTD+KPENIL VN Y
Sbjct: 267 RHMAFQLCQAVKFLHDN-KLTHTDLKPENILF-VNSDY 302
Score = 87.8 bits (216), Expect = 3e-17
Identities = 53/178 (29%), Positives = 88/178 (49%), Gaps = 22/178 (12%)
Query: 484 EPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFE 543
+ ++ + V++ D G+A + H+H + + TR YR+ EV++ G++ P D+WS C+ FE
Sbjct: 313 DERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFE 372
Query: 544 LATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHIT-- 601
G LF+ H E H+A++ +LG +P ++I + K F+ + D T
Sbjct: 373 YYVGFTLFQTHDNRE------HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSA 426
Query: 602 ------KLKPWGLFEVLVEKYEWSQ-EEAAGFTDFLLPMLELIPEKRATAAECLRHPW 652
KP + +Y S+ EE D + MLE P KR T E L+HP+
Sbjct: 427 GRYVRENCKP-------LRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 95.1 bits (235), Expect = 2e-19
Identities = 53/143 (37%), Positives = 85/143 (59%), Gaps = 7/143 (4%)
Query: 79 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 138
RY V++ +G G F V +D + +++VA+K+V++ + + A +EIR+L+ ++ D
Sbjct: 188 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 247
Query: 139 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 198
V+ +L+ F H+CM FE+L L + I K+ +QG + V+K Q +LQ
Sbjct: 248 SMN--VIHMLESFTFRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 301
Query: 199 GLDYLHTKCRIIHTDIKPENILL 221
LD LH K +IIH D+KPENILL
Sbjct: 302 SLDALH-KNKIIHCDLKPENILL 323
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/186 (32%), Positives = 91/186 (48%), Gaps = 23/186 (12%)
Query: 486 KNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELA 545
K+ + K+ D G++C+ ++ IQ+R YR+ E+++GS Y+TP DIWS C+ EL
Sbjct: 324 KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 383
Query: 546 TGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKP 605
TG LF GE+ + D +A ++ELLG P KL+ K +K F KG ++ +
Sbjct: 384 TGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ 437
Query: 606 WGLFEVLV-------------EKYEWSQE----EAAGFTDFLLPMLELIPEKRATAAECL 648
VLV +W + F +FL L P R T A+ L
Sbjct: 438 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL 497
Query: 649 RHPWLN 654
RHPW++
Sbjct: 498 RHPWIS 503
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 95.1 bits (235), Expect = 2e-19
Identities = 53/143 (37%), Positives = 85/143 (59%), Gaps = 7/143 (4%)
Query: 79 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 138
RY V++ +G G F V +D + +++VA+K+V++ + + A +EIR+L+ ++ D
Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267
Query: 139 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 198
V+ +L+ F H+CM FE+L L + I K+ +QG + V+K Q +LQ
Sbjct: 268 SMN--VIHMLESFTFRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321
Query: 199 GLDYLHTKCRIIHTDIKPENILL 221
LD LH K +IIH D+KPENILL
Sbjct: 322 SLDALH-KNKIIHCDLKPENILL 343
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/186 (32%), Positives = 91/186 (48%), Gaps = 23/186 (12%)
Query: 486 KNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELA 545
K+ + K+ D G++C+ ++ IQ+R YR+ E+++GS Y+TP DIWS C+ EL
Sbjct: 344 KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403
Query: 546 TGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKP 605
TG LF GE+ + D +A ++ELLG P KL+ K +K F KG ++ +
Sbjct: 404 TGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ 457
Query: 606 WGLFEVLV-------------EKYEWSQE----EAAGFTDFLLPMLELIPEKRATAAECL 648
VLV +W + F +FL L P R T A+ L
Sbjct: 458 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL 517
Query: 649 RHPWLN 654
RHPW++
Sbjct: 518 RHPWIS 523
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/223 (27%), Positives = 115/223 (51%), Gaps = 23/223 (10%)
Query: 8 LQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGY 67
+ K ++++ +RK ++R + H + + +DDE+ G+
Sbjct: 99 IHCSKSSVRSRRSSPKRK---RNRHCSSHQSRSKSHRRKRSRSIEDDEE---------GH 146
Query: 68 HLVKIGDLFNGRYHVIRKLGWGHFSTV--WLSWDIQGKKFVAMKVVKSAEHYTETALDEI 125
+ + GD+ RY ++ LG G F V + + G VA+K+VK+ Y E A EI
Sbjct: 147 LICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMH-VAVKIVKNVGRYREAARSEI 205
Query: 126 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLP 185
++L+ + ++DPN R VQ+L+ F G H+C+VFE+LG +I ++++
Sbjct: 206 QVLEHLNSTDPNSVFR--CVQMLEWFDHHG----HVCIVFELLGLSTYDFIKENSFLPFQ 259
Query: 186 LPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYI 228
+ ++++ Q+ Q +++LH ++ HTD+KPENIL V Y+
Sbjct: 260 IDHIRQMAYQICQSINFLHHN-KLTHTDLKPENILF-VKSDYV 300
Score = 76.6 bits (187), Expect = 7e-14
Identities = 46/173 (26%), Positives = 83/173 (47%), Gaps = 8/173 (4%)
Query: 484 EPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFE 543
+ + + +K+ D G+A + +H + + TR YR+ EV++ G++ P D+WS C+ E
Sbjct: 310 DERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 369
Query: 544 LATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKL 603
G +F+ H +E H+A++ +LG +P+ +I + K F + D +
Sbjct: 370 YYLGFTVFQTHDSKE------HLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSA 423
Query: 604 KPW--GLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLN 654
+ + L E EE D + MLE P +R T E L+HP+ +
Sbjct: 424 GRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 86.3 bits (212), Expect = 8e-17
Identities = 51/156 (32%), Positives = 88/156 (56%), Gaps = 7/156 (4%)
Query: 66 GYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEI 125
G++L + D RY V+ +G G F V D + + VA+K++++ + + + AL E+
Sbjct: 90 GFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMEL 149
Query: 126 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLP 185
++L+++R D + N VV + D F H C+ FE+LG +L + + +N+QG
Sbjct: 150 KILEALRKKDKD--NTYNVVHMKDFFYFR----NHFCITFELLGINLYELMKNNNFQGFS 203
Query: 186 LPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
L V++ VL+ L L + +IIH D+KPENI+L
Sbjct: 204 LSIVRRFTLSVLKCLQMLSVE-KIIHCDLKPENIVL 238
Score = 80.9 bits (198), Expect = 3e-15
Identities = 53/162 (32%), Positives = 79/162 (48%), Gaps = 6/162 (3%)
Query: 493 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE 552
VK+ D G++C+ H+ IQ+R YRS EV++G Y+ D+WS C+ EL TG LF
Sbjct: 246 VKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLF- 304
Query: 553 PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVL 612
GE + + +A I+E+LG P I + FF KG K+IT + +
Sbjct: 305 --PGE---NEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDS 359
Query: 613 VEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLN 654
+ + F DFL L P R T + L+H W++
Sbjct: 360 KDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIH 401
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 85.5 bits (210), Expect = 1e-16
Identities = 57/198 (28%), Positives = 104/198 (52%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + + + + P S+ E++ G DDD + ++V+ G+ + RY +
Sbjct: 66 KKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDS 115
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D Q ++ VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 116 LIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYI 173
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + ++++G+ L +K+ QQ+ L +L
Sbjct: 174 VHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLA 229
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 230 TPELSIIHCDLKPENILL 247
Score = 65.9 bits (159), Expect = 1e-10
Identities = 35/107 (32%), Positives = 63/107 (58%), Gaps = 6/107 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G+ Y+ D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTK 593
G+ LF SG + + D + I+E+LG P ++ ++++F +
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER 349
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 85.5 bits (210), Expect = 1e-16
Identities = 57/198 (28%), Positives = 104/198 (52%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + + + + P S+ E++ G DDD + ++V+ G+ + RY +
Sbjct: 66 KKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDS 115
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D Q ++ VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 116 LIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYI 173
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + ++++G+ L +K+ QQ+ L +L
Sbjct: 174 VHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLA 229
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 230 TPELSIIHCDLKPENILL 247
Score = 66.2 bits (160), Expect = 9e-11
Identities = 48/168 (28%), Positives = 82/168 (48%), Gaps = 20/168 (11%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G+ Y+ D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPW 606
G+ LF SG + + D + I+E+LG P ++ ++++F + P
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER----------LPG 352
Query: 607 GLFEVLVEKYEWSQEEAAGF----TDFLLPMLELIPEKRATAAECLRH 650
G + + K + G D +L MLE P R + L+H
Sbjct: 353 GGWTLRRTKELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQH 400
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 85.5 bits (210), Expect = 1e-16
Identities = 57/198 (28%), Positives = 104/198 (52%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + + + + P S+ E++ G DDD + ++V+ G+ + RY +
Sbjct: 66 KKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDS 115
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D Q ++ VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 116 LIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYI 173
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + ++++G+ L +K+ QQ+ L +L
Sbjct: 174 VHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLA 229
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 230 TPELSIIHCDLKPENILL 247
Score = 65.9 bits (159), Expect = 1e-10
Identities = 35/107 (32%), Positives = 63/107 (58%), Gaps = 6/107 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G+ Y+ D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTK 593
G+ LF SG + + D + I+E+LG P ++ ++++F +
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER 349
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/198 (29%), Positives = 101/198 (51%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + +H+ S E++ G DDD + ++VK G+ + RY +
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYD----------YIVKNGEKWMDRYEIDS 163
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D +++VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 164 LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYI 221
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + +N++G+ L +K QQ+ L +L
Sbjct: 222 VHLKRHFMFR----NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 277
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 278 TPELSIIHCDLKPENILL 295
Score = 67.8 bits (164), Expect = 3e-11
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 6/110 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G Y+ D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGD 596
G+ LF SG + D + I+E+LG P ++ +++FF K D
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 400
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/198 (29%), Positives = 101/198 (51%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + +H+ S E++ G DDD + ++VK G+ + RY +
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYD----------YIVKNGEKWMDRYEIDS 163
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D +++VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 164 LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYI 221
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + +N++G+ L +K QQ+ L +L
Sbjct: 222 VHLKRHFMFR----NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 277
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 278 TPELSIIHCDLKPENILL 295
Score = 67.8 bits (164), Expect = 3e-11
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 6/110 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G Y+ D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGD 596
G+ LF SG + D + I+E+LG P ++ +++FF K D
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 400
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/198 (29%), Positives = 101/198 (51%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + +H+ S E++ G DDD + ++VK G+ + RY +
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYD----------YIVKNGEKWMDRYEIDS 163
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D +++VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 164 LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYI 221
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + +N++G+ L +K QQ+ L +L
Sbjct: 222 VHLKRHFMFR----NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 277
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 278 TPELSIIHCDLKPENILL 295
Score = 67.8 bits (164), Expect = 3e-11
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 6/110 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G Y+ D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGD 596
G+ LF SG + D + I+E+LG P ++ +++FF K D
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 400
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/198 (29%), Positives = 101/198 (51%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + +H+ S E++ G DDD + ++VK G+ + RY +
Sbjct: 105 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYD----------YIVKNGEKWMDRYEIDS 154
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D +++VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 155 LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYI 212
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + +N++G+ L +K QQ+ L +L
Sbjct: 213 VHLKRHFMFR----NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 268
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 269 TPELSIIHCDLKPENILL 286
Score = 67.8 bits (164), Expect = 3e-11
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 6/110 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G Y+ D+WS C+ E+ T
Sbjct: 288 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 347
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGD 596
G+ LF SG + D + I+E+LG P ++ +++FF K D
Sbjct: 348 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 391
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/198 (29%), Positives = 101/198 (51%), Gaps = 17/198 (8%)
Query: 25 KSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIR 84
K + +H+ S E++ G DDD + ++VK G+ + RY +
Sbjct: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYD----------YIVKNGEKWMDRYEIDS 163
Query: 85 KLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMV 144
+G G F V ++D +++VA+K++K+ + + A E+RLL+ + D + +
Sbjct: 164 LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE--MKYYI 221
Query: 145 VQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH 204
V L F H+C+VFE+L ++L + +N++G+ L +K QQ+ L +L
Sbjct: 222 VHLKRHFMFR----NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 277
Query: 205 T-KCRIIHTDIKPENILL 221
T + IIH D+KPENILL
Sbjct: 278 TPELSIIHCDLKPENILL 295
Score = 67.8 bits (164), Expect = 3e-11
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 6/110 (5%)
Query: 487 NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELAT 546
N ++ +KI D G++C + + + IQ+R YRS EVL+G Y+ D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 547 GDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGD 596
G+ LF SG + D + I+E+LG P ++ +++FF K D
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 400
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 79.7 bits (195), Expect = 8e-15
Identities = 53/166 (31%), Positives = 93/166 (56%), Gaps = 9/166 (5%)
Query: 66 GYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWD-IQGKKFVAMKVVKSAEHYTETALDE 124
GY+ V IG++ + RY+V G G FS V + D + + VA+K++++ E +T L E
Sbjct: 673 GYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKE 732
Query: 125 IRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQ-G 183
+ LK + ++DP+D + ++L F + H+C+VFE L +L + + K G
Sbjct: 733 LEFLKKLNDADPDD--KFHCLRLFRHF----YHKQHLCLVFEPLSMNLREVLKKYGKDVG 786
Query: 184 LPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIR 229
L + V+ QQ+ L L +C I+H DIKP+NIL++ ++ ++
Sbjct: 787 LHIKAVRSYSQQLFLALKLL-KRCNILHADIKPDNILVNESKTILK 831
Score = 59.3 bits (142), Expect = 1e-08
Identities = 35/115 (30%), Positives = 58/115 (50%), Gaps = 7/115 (6%)
Query: 487 NAEKLKVKIADLGNACWVHKH-FTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELA 545
N K +K+ D G+A V + T + +R YR+ E++IG Y+ D+WS C +EL
Sbjct: 824 NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY 883
Query: 546 TGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI 600
TG LF + + L ++L GK+P K+I G + + F + + +I
Sbjct: 884 TGKILFPGKTNNHM------LKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYI 932
Score = 29.6 bits (65), Expect = 9.2
Identities = 18/84 (21%), Positives = 37/84 (44%)
Query: 233 AEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEM 292
A + + RS + P S + PKP DK +++ L ++ +Q++ + +
Sbjct: 333 ASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRA 392
Query: 293 EKESGPGQKRPNKQEESESPVERP 316
+ S ++R ++ SP RP
Sbjct: 393 KSRSLERKRREPERRRLSSPRTRP 416
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 49/160 (30%), Positives = 83/160 (51%), Gaps = 10/160 (6%)
Query: 64 KGGYHLVKIGDL--FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETA 121
+G Y LV+ L Y V+ LG G F V W K+ VA+K++K+ Y
Sbjct: 172 EGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQG 231
Query: 122 LDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNY 181
E+ +L + + + ++ N V+ + F+ + H C+VFE+L +L ++ ++ +
Sbjct: 232 QIEVSILSRLSSENADEYN---FVRSYECFQ----HKNHTCLVFEMLEQNLYDFLKQNKF 284
Query: 182 QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
LPL ++ I+QQV L L + +IH D+KPENI+L
Sbjct: 285 SPLPLKYIRPILQQVATALMKLKS-LGLIHADLKPENIML 323
Score = 47.4 bits (111), Expect = 4e-05
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 11/120 (9%)
Query: 479 LVNPLEPKNAEKLKVKIADLGNACWVHKHFTED-IQTRQYRSLEVLIGSGYNTPADIWST 537
LV+P+ + +VK+ D G+A V K +Q+R YR+ E+++G + D+WS
Sbjct: 323 LVDPVR----QPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 378
Query: 538 ACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL 597
C+ EL G L+ EY D I I + G L+ AG + FF + +L
Sbjct: 379 GCVIAELFLGWPLYP--GASEY----DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNL 432
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 72.0 bits (175), Expect = 2e-12
Identities = 49/160 (30%), Positives = 83/160 (51%), Gaps = 10/160 (6%)
Query: 64 KGGYHLVKIGDL--FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETA 121
+G Y LV+ L Y V+ LG G F V W K+ VA+K++K+ Y
Sbjct: 172 EGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQG 231
Query: 122 LDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNY 181
E+ +L + + + ++ N V+ + F+ + H C+VFE+L +L ++ ++ +
Sbjct: 232 QIEVSILSRLSSENADEYN---FVRSYECFQ----HKNHTCLVFEMLEQNLYDFLKQNKF 284
Query: 182 QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
LPL ++ I+QQV L L + +IH D+KPENI+L
Sbjct: 285 SPLPLKYIRPILQQVATALMKLKS-LGLIHADLKPENIML 323
Score = 47.4 bits (111), Expect = 4e-05
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 11/120 (9%)
Query: 479 LVNPLEPKNAEKLKVKIADLGNACWVHKHFTED-IQTRQYRSLEVLIGSGYNTPADIWST 537
LV+P+ + +VK+ D G+A V K +Q+R YR+ E+++G + D+WS
Sbjct: 323 LVDPVR----QPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 378
Query: 538 ACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL 597
C+ EL G L+ EY D I I + G L+ AG + FF + +L
Sbjct: 379 GCVIAELFLGWPLYP--GASEY----DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNL 432
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 69.7 bits (169), Expect = 8e-12
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 64 KGGYHLVKIGDL--FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETA 121
+G Y LV+ L Y V+ LG G F V W + VA+K++K+ Y
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 122 LDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNY 181
E+ +L + +D N V+ + F+ + H C+VFE+L +L ++ ++ +
Sbjct: 241 QIEVSILARLSTESADDYN---FVRAYECFQ----HKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 182 QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
LPL ++ ++QQV L L + +IH D+KPENI+L
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKS-LGLIHADLKPENIML 332
Score = 51.2 bits (121), Expect = 3e-06
Identities = 53/206 (25%), Positives = 85/206 (41%), Gaps = 41/206 (19%)
Query: 479 LVNPLEPKNAEKLKVKIADLGNACWVHKHFTED-IQTRQYRSLEVLIGSGYNTPADIWST 537
LV+P + + +VK+ D G+A V K +Q+R YR+ E+++G + D+WS
Sbjct: 332 LVDP----SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 387
Query: 538 ACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL 597
C+ EL G L+ EY D I I + G L+ AG + FF + D
Sbjct: 388 GCVIAELFLGWPLYP--GASEY----DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 441
Query: 598 KH-ITKLK-------PWGLFEVLVEKYEWS----------------------QEEAAGFT 627
+ + +LK G+ KY ++ + + F
Sbjct: 442 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFI 501
Query: 628 DFLLPMLELIPEKRATAAECLRHPWL 653
D L ML + +KR T E L HP++
Sbjct: 502 DLLKKMLTIDADKRITPIETLNHPFV 527
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 69.7 bits (169), Expect = 8e-12
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 64 KGGYHLVKIGDL--FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETA 121
+G Y LV+ L Y V+ LG G F V W + VA+K++K+ Y
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 122 LDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNY 181
E+ +L + +D N V+ + F+ + H C+VFE+L +L ++ ++ +
Sbjct: 241 QIEVSILARLSTESADDYN---FVRAYECFQ----HKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 182 QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
LPL ++ ++QQV L L + +IH D+KPENI+L
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKS-LGLIHADLKPENIML 332
Score = 51.2 bits (121), Expect = 3e-06
Identities = 53/206 (25%), Positives = 85/206 (41%), Gaps = 41/206 (19%)
Query: 479 LVNPLEPKNAEKLKVKIADLGNACWVHKHFTED-IQTRQYRSLEVLIGSGYNTPADIWST 537
LV+P + + +VK+ D G+A V K +Q+R YR+ E+++G + D+WS
Sbjct: 332 LVDP----SRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 387
Query: 538 ACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDL 597
C+ EL G L+ EY D I I + G L+ AG + FF + D
Sbjct: 388 GCVIAELFLGWPLYP--GASEY----DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 441
Query: 598 KH-ITKLK-------PWGLFEVLVEKYEWS----------------------QEEAAGFT 627
+ + +LK G+ KY ++ + + F
Sbjct: 442 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFI 501
Query: 628 DFLLPMLELIPEKRATAAECLRHPWL 653
D L ML + +KR T E L HP++
Sbjct: 502 DLLKKMLTIDADKRITPIETLNHPFV 527
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 69.7 bits (169), Expect = 8e-12
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 64 KGGYHLVKIGDL--FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETA 121
+G Y LV+ L Y V+ LG G F V W + VA+K++K+ Y
Sbjct: 181 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 240
Query: 122 LDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNY 181
E+ +L + +D N V+ + F+ + H C+VFE+L +L ++ ++ +
Sbjct: 241 QIEVSILARLSTESADDYN---FVRAYECFQ----HKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 182 QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
LPL ++ ++QQV L L + +IH D+KPENI+L
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKS-LGLIHADLKPENIML 332
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/146 (32%), Positives = 79/146 (54%), Gaps = 16/146 (10%)
Query: 80 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSDP 136
+ + K+G G + V+ + + + VA+K ++ E TA+ EI LLK +
Sbjct: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL----- 58
Query: 137 NDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQV 196
N PN +V+LLD + +VFE L L K++ S G+PLP +K + Q+
Sbjct: 59 NHPN---IVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 111
Query: 197 LQGLDYLHTKCRIIHTDIKPENILLS 222
LQGL + H+ R++H D+KP+N+L++
Sbjct: 112 LQGLAFCHSH-RVLHRDLKPQNLLIN 136
Score = 40.0 bits (92), Expect = 0.007
Identities = 47/166 (28%), Positives = 69/166 (41%), Gaps = 27/166 (16%)
Query: 493 VKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGSGY-NTPADIWSTACMAFELATGD 548
+K+AD G A + +T ++ T YR+ E+L+G Y +T DIWS C+ E+ T
Sbjct: 141 IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR 200
Query: 549 YLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGL 608
LF S + D + I LG P +++ G T D K W
Sbjct: 201 ALFPGDS------EIDQLFRIFRTLG-TPDEVVWPG------VTSMPDYK--PSFPKWAR 245
Query: 609 --FEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPW 652
F +V + E+ L ML P KR +A L HP+
Sbjct: 246 QDFSKVVPPLD---EDG---RSLLSQMLHYDPNKRISAKAALAHPF 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,720,112
Number of Sequences: 37866
Number of extensions: 1313490
Number of successful extensions: 14330
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 397
Number of HSP's successfully gapped in prelim test: 834
Number of HSP's that attempted gapping in prelim test: 9044
Number of HSP's gapped (non-prelim): 4871
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.