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Search of human proteins with 4580422
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4580422 natriuretic peptide receptor B precursor [Homo
sapiens]
(1047 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 2115 0.0
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 1241 0.0
gi|134152694 guanylate cyclase 2F [Homo sapiens] 504 e-142
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 485 e-137
gi|222080083 guanylate cyclase 2C [Homo sapiens] 426 e-119
gi|4505441 natriuretic peptide receptor C/guanylate cyclase C (a... 195 2e-49
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 181 3e-45
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 176 1e-43
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 176 1e-43
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 176 1e-43
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 176 1e-43
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 176 1e-43
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 175 2e-43
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 170 6e-42
gi|34486092 adenylate cyclase 5 [Homo sapiens] 123 1e-27
gi|24497587 adenylate cyclase 4 [Homo sapiens] 120 7e-27
gi|148536830 adenylate cyclase 3 [Homo sapiens] 119 1e-26
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 119 2e-26
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 119 2e-26
gi|4557257 adenylate cyclase 8 [Homo sapiens] 118 3e-26
gi|4557255 adenylate cyclase 7 [Homo sapiens] 113 1e-24
gi|115387102 adenylate cyclase 2 [Homo sapiens] 113 1e-24
gi|50959205 adenylate cyclase 9 [Homo sapiens] 111 3e-24
gi|31083193 adenylate cyclase 1 [Homo sapiens] 111 4e-24
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 100 1e-20
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 99 3e-20
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 99 3e-20
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 96 1e-19
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 92 2e-18
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 92 3e-18
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 2115 bits (5481), Expect = 0.0
Identities = 1047/1047 (100%), Positives = 1047/1047 (100%)
Query: 1 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL 60
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL
Sbjct: 1 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL 60
Query: 61 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL 120
PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL
Sbjct: 61 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL 120
Query: 121 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH 180
TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH
Sbjct: 121 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH 180
Query: 181 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA 240
YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA
Sbjct: 181 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA 240
Query: 241 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE 300
QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
Sbjct: 241 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE 300
Query: 301 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED 360
PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED
Sbjct: 301 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED 360
Query: 361 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW 420
GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW
Sbjct: 361 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW 420
Query: 421 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK 480
TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK
Sbjct: 421 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK 480
Query: 481 LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT 540
LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT
Sbjct: 481 LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT 540
Query: 541 GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP 600
GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP
Sbjct: 541 GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP 600
Query: 601 RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI 660
RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
Sbjct: 601 RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI 660
Query: 661 TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR 720
TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR
Sbjct: 661 TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR 720
Query: 721 SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG 780
SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG
Sbjct: 721 SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG 780
Query: 781 QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH 840
QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH
Sbjct: 781 QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH 840
Query: 841 SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF 900
SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF
Sbjct: 841 SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF 900
Query: 901 DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV 960
DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV
Sbjct: 901 DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV 960
Query: 961 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR 1020
HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR
Sbjct: 961 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR 1020
Query: 1021 GDVEMKGKGKMRTYWLLGERKGPPGLL 1047
GDVEMKGKGKMRTYWLLGERKGPPGLL
Sbjct: 1021 GDVEMKGKGKMRTYWLLGERKGPPGLL 1047
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 1241 bits (3212), Expect = 0.0
Identities = 646/1050 (61%), Positives = 777/1050 (74%), Gaps = 25/1050 (2%)
Query: 6 LLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALA---VEALGRALPV 62
LLLL+ L +R A NLT+AVVLP N SY W+W RVGPAV LA V+A LP
Sbjct: 16 LLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPG 75
Query: 63 -DLRFVSSELE---GACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLP 118
+R V E G CS+ APL+AVDLK H+P + LGPGCVY AA V RF +HWR+P
Sbjct: 76 WTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVP 135
Query: 119 LLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDR 178
LLTAGA A GF K D Y R GPS KLG+FV LH W +A +LY D+
Sbjct: 136 LLTAGAPALGFGVK-DEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEE 194
Query: 179 PHYFTIEGVFEALQGS-NLSVQHQVYAREPGGPEQATHFIRA------NGRIVYICGPLE 231
+F +EG+F ++ N++V H +A + +H+ R GR++YIC +
Sbjct: 195 HCFFLVEGLFMRVRDRLNITVDHLEFAED-----DLSHYTRLLRTMPRKGRVIYICSSPD 249
Query: 232 MLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQ 291
++L A L DYVFF+LD+FG+SL+ G A RPW+ R Q + R+AFQ
Sbjct: 250 AFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWE--RGDGQDVSARQAFQ 307
Query: 292 TVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNET 351
+ITY++P NPEY EF +L A E F + L+N I F+DG+LLY + + ET
Sbjct: 308 AAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTET 367
Query: 352 IQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHY 411
+ GGT DG I ++M R + GVTG + +D + DRETDF LW M D ++G F+ +Y
Sbjct: 368 LAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDM-DPENGAFRVVLNY 426
Query: 412 SGAEKQ-IWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMF 470
+G ++ + +GR + W G PP D P C FD +DP+C++ LSTL ++AL ++ +
Sbjct: 427 NGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGI 486
Query: 471 GVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTA 530
+ SF I+RK+ LEKELAS LWR+RWE+++ + ER+ + AGSRLTLS RGS+YGSL+T
Sbjct: 487 LIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTT 546
Query: 531 HGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPP 590
G++Q+FA T ++KGN+VA+K VN+KRIELTR+VLFELKHMRDVQ HLTRF+GAC DPP
Sbjct: 547 EGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPP 606
Query: 591 NICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNC 650
NICI+TEYCPRGSLQDILEN+SI LDWMFRYSL ND+VKGM FLHN I SHG+LKSSNC
Sbjct: 607 NICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNC 666
Query: 651 VVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSF 710
VVD RFVLKITDYGL SFR +P+ H +YAKKLWTAPELL P G Q DVYSF
Sbjct: 667 VVDGRFVLKITDYGLESFRDL-DPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSF 725
Query: 711 GIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWA 770
GIILQEIALRSG F++EGLDLSPKEI+++V G++P FRPS+ EEL LLM+RCWA
Sbjct: 726 GIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWA 785
Query: 771 QDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKA 830
+DP ERP F QI+ +R+FN+E ++ILDNLL RMEQYANNLE+LVEERTQAYLEEKRKA
Sbjct: 786 EDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKA 845
Query: 831 EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLY 890
EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLY
Sbjct: 846 EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLY 905
Query: 891 TCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRP 950
TCFDA+IDNFDVYKVETIGDAYMVVSGLP RNG+ HA E+ARMALALLDAV SFRIRHRP
Sbjct: 906 TCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRP 965
Query: 951 HDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD 1010
+QLRLRIG+HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+ALKIH+SS TK L+
Sbjct: 966 QEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLE 1025
Query: 1011 ELGCFQLELRGDVEMKGKGKMRTYWLLGER 1040
E G F+LELRGDVEMKGKGK+RTYWLLGER
Sbjct: 1026 EFGGFELELRGDVEMKGKGKVRTYWLLGER 1055
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 504 bits (1297), Expect = e-142
Identities = 348/941 (36%), Positives = 504/941 (53%), Gaps = 74/941 (7%)
Query: 136 YRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSN 195
Y T RT PS ++ +VT+ +F W A A ++ +D+ T V AL+
Sbjct: 162 YPTFSRTLPSPIRV---LVTVMKYFQW-AHAGVI----SSDEDIWVHTANRVASALRSHG 213
Query: 196 LSVQHQVYA-REPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRE----------N 244
L V + ++ +A I RI I + +H L+ + +
Sbjct: 214 LPVGVVLTTGQDSQSMRKALQRIHQADRIRII---IMCMHSALIGGETQMHLLECAHDLK 270
Query: 245 LTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNP 304
+T+G YVF D SL P + T P++ R + LREA+ VL IT
Sbjct: 271 MTDGTYVFVPYDALLYSL---PYKHT--PYRVLRNNPK---LREAYDAVLTITVESQEKT 322
Query: 305 EYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRI 364
YQ F AR + +L ++ + G Y+ I A+ +N ++E G + +
Sbjct: 323 FYQAFTEAA---ARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENG-QAGAASL 378
Query: 365 VEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRP 424
V+ + ++HG L+ D N + +++V+ +L + + + + G P
Sbjct: 379 VQHSRNMQFHGFNQLMRTDSNGNGISEYVILDT-NLKEWELHSTYTVDMEMELLRFGGTP 437
Query: 425 IPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIF-----R 479
I + G PP + C F + C A++ T + + ++ F F
Sbjct: 438 IHFPGGRPPRADAKCWF-AEGKICHGGIDPAFAMMVCLT-LLIALLSINGFAYFIRRRIN 495
Query: 480 KLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLR-------------GSSYGS 526
K+ L K +L + E++ F N + GSR ++S + S GS
Sbjct: 496 KIQLIKGPNRILLTL--EDVTFINPH-FGSKRGSRASVSFQITSEVQSGRSPRLSFSSGS 552
Query: 527 LMTAHGKYQIFANTGHFKGNVVAIKHVNK------KRIELTRQVLFELKHMRDVQFNHLT 580
L A + +N ++G+ V +K + K I+ +FE+ M+D++ ++
Sbjct: 553 LTPATYEN---SNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEM--MKDLRHENIN 607
Query: 581 RFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIIS 640
+G D IVTE+C RGSL+DIL N + LDWMF+ SL+ DL+KGM +LH+
Sbjct: 608 PLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFV 667
Query: 641 SHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTT 700
HG LKS NCVVD RFVLK+TDYG + + + LWTAPELL
Sbjct: 668 -HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRL 726
Query: 701 GMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEE 760
G DVYSF II+QE+ +R PF + +DL +EI+ +++ P +RP + E
Sbjct: 727 GSFAGDVYSFAIIMQEVMVRGTPFCM--MDLPAQEIINRLKKPP-PVYRPVVPPEHAPPE 783
Query: 761 LVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERT 820
+ LM++CWA+ +RP F +I + FNK T+I+D++L +EQY++NLE L+ ERT
Sbjct: 784 CLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERT 843
Query: 821 QAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPM 880
+ EK+K E LL Q+LP SVAE LK+G TV+ E FD VT+YFSDIVGFT +SA S P+
Sbjct: 844 EELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPI 903
Query: 881 QVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDA 940
+VV LLNDLYT FDAII + DVYKVETIGDAYMV SGLP RNG RHA EIA M+L +L +
Sbjct: 904 EVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSS 963
Query: 941 VSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIH 1000
V +F++RH P +R+RIG+H+GPV AGVVGL MPRYCLFGDTVNTASRMES G +IH
Sbjct: 964 VGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIH 1023
Query: 1001 VSSTTKDALDELG-CFQLELRGDVEMKGKGKMRTYWLLGER 1040
VS +T L L +++ELRG E+KGKG T+WL+G++
Sbjct: 1024 VSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKK 1064
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 485 bits (1249), Expect = e-137
Identities = 336/937 (35%), Positives = 483/937 (51%), Gaps = 75/937 (8%)
Query: 142 TGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEG---VFEALQGSNLSV 198
T P+ + + L F W AR AL+ P +E + AL+ L V
Sbjct: 161 TAPAVTPAADALYALLRAFGW-ARVALV-------TAPQDLWVEAGRSLSTALRARGLPV 212
Query: 199 QHQVYAREP---GGPEQATHFIRANGRIVYICGPLEMLHEILLQAQREN----------L 245
V + EP G +A +R R+ + + ++H +LL + + L
Sbjct: 213 A-SVTSMEPLDLSGAREALRKVRDGPRVTAV---IMVMHSVLLGGEEQRYLLEAAEELGL 268
Query: 246 TNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPE 305
T+G VF D +L GP + LR A VL +T P
Sbjct: 269 TDGSLVFLPFDTIHYALSPGPEALAALA--------NSSQLRRAHDAVLTLTRHCPSEGS 320
Query: 306 YQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNET-IQEGGTREDGLRI 364
+ R + R + +L ++ + G YD + L A + E GG G +
Sbjct: 321 VLDSLRRA--QERRELPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAV 378
Query: 365 VEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHY--SGAEKQIWWTG 422
++ + G G D D E FVL D D+ + A Y A G
Sbjct: 379 ARHIRDAQVPGFCG----DLGGDEEPPFVLL---DTDAAGDRLFATYMLDPARGSFLSAG 431
Query: 423 RPIPWVKG-APPSDNPPCAFDLDDPSCDKTP-----LSTLAIVALGTGITFIMFGVSSFL 476
+ + +G + P +P C FD ++ L L +V +G F+ V L
Sbjct: 432 TRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRL 491
Query: 477 IFRKLML-EKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQ 535
+ +++ ++ + I + G S + +G+ S SL S + + ++
Sbjct: 492 LHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRS----SLGARSMSDIRSGPSQHL 547
Query: 536 IFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIG---------- 584
N G ++G+ V +K + I + +++++ ++ ++G
Sbjct: 548 DSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGP 607
Query: 585 ACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGS 644
A + N+ +V+E+C RGSLQD+L I LDWMF+ SL+ DL+KG+ +LH+ ++ HG
Sbjct: 608 AALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVA-HGR 666
Query: 645 LKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQK 704
LKS NC+VD RFVLKITD+G + +LWTAPELL L G
Sbjct: 667 LKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLA 726
Query: 705 ADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLL 764
DV+S II+QE+ RS P+ + L+L+P+E+VQ+VR+ P RP + Q E +LL
Sbjct: 727 GDVFSLAIIMQEVVCRSAPYAM--LELTPEEVVQRVRSPP-PLCRPLVSMDQAPVECILL 783
Query: 765 MERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYL 824
M++CWA+ P RP + NK T+I+D++L +EQY++NLE L+ ERT+
Sbjct: 784 MKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELE 843
Query: 825 EEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVT 884
EK+K + LL Q+LP SVAE LK G V+ E F+ VT+YFSDIVGFT +SA S P++VV
Sbjct: 844 LEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVD 903
Query: 885 LLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSF 944
LLNDLYT FDAII + DVYKVETIGDAYMV SGLP RNGQRHA EIA M+L +L AV +F
Sbjct: 904 LLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTF 963
Query: 945 RIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSST 1004
R+RH P +R+RIG+H+GP AGVVGL MPRYCLFGDTVNTASRMES G +IHV+ +
Sbjct: 964 RMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLS 1023
Query: 1005 TKDALDELGC-FQLELRGDVEMKGKGKMRTYWLLGER 1040
T L L +Q+ELRG E+KGKG T+WL+G R
Sbjct: 1024 TVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRR 1060
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 426 bits (1096), Expect = e-119
Identities = 318/972 (32%), Positives = 473/972 (48%), Gaps = 115/972 (11%)
Query: 95 LLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVV 154
+L+GP C Y + + P+++AG+ F D+ TL R A KL F+V
Sbjct: 118 VLIGPSCTYSTFQMY-LDTELSYPMISAGS----FGLSCDYKETLTRLMSPARKLMYFLV 172
Query: 155 TL-------HGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREP 207
++W+ + +Y + T+ ++ + + ++ + + +V R+
Sbjct: 173 NFWKTNDLPFKTYSWST--SYVYKNG-TETEDCFWYLNALEASVSYFSHELGFKVVLRQD 229
Query: 208 GGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPT 267
+ ++ +CG E L+++ + + D V +D+F +
Sbjct: 230 KEFQDILMDHNRKSNVIIMCGGPEFLYKL----KGDRAVAEDIVIILVDLFNDQY----- 280
Query: 268 RATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGP 327
++DN T + + VLV+T P N +R L + DF +
Sbjct: 281 ------FEDNVTAP------DYMKNVLVLTL-SPGNSLLNSSFSRNLSPTKRDFAL---- 323
Query: 328 SLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNND 387
+ +GILL+ +L + E G + + + G G V +D D
Sbjct: 324 --------AYLNGILLFGHML-KIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGD 374
Query: 388 RETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRP--IPWVKGAPPSDNPPCAFDLDD 445
++ VL +D+ ++ Y + + W P+D
Sbjct: 375 VDSTMVL-LYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPND---------- 423
Query: 446 PSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSE 505
+ P + V TG ++ V+ L+ RK + EL W
Sbjct: 424 -ITGRGPQILMIAVFTLTGAVVLLLLVA-LLMLRKYRKDYELRQKKWS------------ 469
Query: 506 RYHKGAGSRLTLSLRGSSYGSLMTAHGK----YQIFANTGHFKGNVVAIKHVNKKRIELT 561
H + L +++ SL K Q + K V+ +K + T
Sbjct: 470 --HIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVI-LKDLKHNDGNFT 526
Query: 562 RQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSIN------L 615
+ EL + + + +LT+F G I V EYC RGSL+++L ND+I+ +
Sbjct: 527 EKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFM 585
Query: 616 DWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD 675
DW F+ S++ D+ KGM++LH+S HG LKS+NCVVDSR V+KITD+G S
Sbjct: 586 DWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPK--- 642
Query: 676 DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFY-LEGLDLSPK 734
K LWTAPE L + QK DVYS+GII QEI LR FY L D + K
Sbjct: 643 -------KDLWTAPEHLRQANIS----QKGDVYSYGIIAQEIILRKETFYTLSCRDRNEK 691
Query: 735 EIVQKVRNGQRPYFRPSIDRTQLNE---ELVLLMERCWAQDPAERPDFGQIKGFIRR--- 788
+ NG +P FRP + E E+ LL++ CW +DP +RPDF +I+ + +
Sbjct: 692 IFRVENSNGMKP-FRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFG 750
Query: 789 -FNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLK 847
F+ + S +D L+ R++ Y+ NLE LVEERTQ Y E+ +A+ L + +LP V + LK
Sbjct: 751 LFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLK 810
Query: 848 RGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVET 907
V+ E ++ VTIYFSDIVGFT + STPM+VV +LND+Y FD I+D+ DVYKVET
Sbjct: 811 EKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVET 870
Query: 908 IGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCA 967
IGDAYMV SGLP RNG RHA +IA+MAL +L + +F + H P + +RIGVH+GP A
Sbjct: 871 IGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAA 930
Query: 968 GVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGC-FQLELRGDVEMK 1026
GVVG+KMPRYCLFGDTVNTASRMES G L+IHVS +T L C F E+RG+ +K
Sbjct: 931 GVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLK 990
Query: 1027 GKGKMRTYWLLG 1038
G+G TYWL G
Sbjct: 991 GRGNETTYWLTG 1002
>gi|4505441 natriuretic peptide receptor C/guanylate cyclase C
(atrionatriuretic peptide receptor C) [Homo sapiens]
Length = 540
Score = 195 bits (495), Expect = 2e-49
Identities = 146/477 (30%), Positives = 235/477 (49%), Gaps = 35/477 (7%)
Query: 19 PPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALG------RALPVDLRFVSSELE 72
PP + + + V+LP+ + SY ++ RV PA+ A+ ++ R LP RF + +
Sbjct: 49 PP--QKIEVLVLLPQDD-SYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYED 105
Query: 73 GACSEYLAPLSAVDLKLYH---DPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGF 129
C A S VD PDL+LGP C Y AA VAR ASHW LP+L+AGA+A+GF
Sbjct: 106 SDCGNR-ALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGF 164
Query: 130 SAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFE 189
K+ Y L R P+ K+GE ++ L H +W +RAAL+Y D + +R YFT+EGV E
Sbjct: 165 QHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHW-SRAALVYSDDKL-ERNCYFTLEGVHE 222
Query: 190 ALQGSNLSVQHQVYAREPGGP---EQATHFIRANGRIVYICGPLEMLHEILLQAQRENLT 246
Q L +Y+ + E I+A+ R+V +C + + I+L A R +T
Sbjct: 223 VFQEEGLHT--SIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMT 280
Query: 247 NGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEY 306
+GDY FF +++F S + W+ R + ++A+ ++ +T PE+
Sbjct: 281 SGDYAFFNIELFNSSSYGDGS------WK--RGDKHDFEAKQAYSSLQTVTLLRTVKPEF 332
Query: 307 QEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVE 366
++F + + E G+ + +N+ F+D ILLY L+E ++ G +++DG +I++
Sbjct: 333 EKFSMEVK-SSVEKQGLNM-EDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQ 390
Query: 367 KMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRP-- 424
+ R + G+ G V +D N DR DF + AM D+++G + Y G E + + RP
Sbjct: 391 QTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGR--FEMRPNV 448
Query: 425 -IPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK 480
PW D + C L A+ + G + +F FRK
Sbjct: 449 KYPWGPLKLRIDENRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRK 505
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 181 bits (459), Expect = 3e-45
Identities = 104/211 (49%), Positives = 136/211 (64%), Gaps = 7/211 (3%)
Query: 799 DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFD 858
D L RM++ L+ +E QA EEK+K LLY I P VA+QL +G+ VQA FD
Sbjct: 463 DGLKKRMDK----LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD 518
Query: 859 SVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL 918
VT+ FSDIVGFTA+ A+ TPMQV+++LN+LYT FD D+YKVETIGDAY V +GL
Sbjct: 519 DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL 578
Query: 919 PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYC 978
R HA IA MAL +++ S + +++RIG+H+G V AGVVG++MPRYC
Sbjct: 579 -HRKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYC 635
Query: 979 LFGDTVNTASRMESNGQALKIHVSSTTKDAL 1009
LFG+ V AS+ ES +I+VS TT L
Sbjct: 636 LFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 176 bits (446), Expect = 1e-43
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 190 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 249
Query: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 250 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 308
Query: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 309 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 366
Query: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
A++ ES KI+VS TT L + F R E+
Sbjct: 367 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 407
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 176 bits (446), Expect = 1e-43
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 543
Query: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
A++ ES KI+VS TT L + F R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 176 bits (446), Expect = 1e-43
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 543
Query: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
A++ ES KI+VS TT L + F R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 176 bits (446), Expect = 1e-43
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 543
Query: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
A++ ES KI+VS TT L + F R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 176 bits (446), Expect = 1e-43
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 543
Query: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
A++ ES KI+VS TT L + F R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 175 bits (444), Expect = 2e-43
Identities = 96/201 (47%), Positives = 132/201 (65%), Gaps = 3/201 (1%)
Query: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 543
Query: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 985 NTASRMESNGQALKIHVSSTT 1005
A++ ES KI+VS TT
Sbjct: 602 TLANKFESCSVPRKINVSPTT 622
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 170 bits (431), Expect = 6e-42
Identities = 101/231 (43%), Positives = 137/231 (59%), Gaps = 15/231 (6%)
Query: 821 QAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP- 879
+A +EK+K + LLY +LP SVA +L+ V A+ +D+VTI FS IVGF A ++
Sbjct: 381 RALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASG 440
Query: 880 ---MQVVTLLNDLYTCFDAIID---NFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARM 933
M++V LLNDLYT FD + D N VYKVET+GD YM VSGLP HA I +
Sbjct: 441 EGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP-EPCIHHARSICHL 499
Query: 934 ALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESN 993
AL +++ ++ + +++ IG+HTG V GV+G +MPRYCLFG+TVN SR E+
Sbjct: 500 ALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETT 556
Query: 994 GQALKIHVSSTTKDAL----DELGCFQLELRGDVEMKGKGKMRTYWLLGER 1040
G+ KI+VS T L + F LE RG V MKGK + W L +
Sbjct: 557 GEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRK 607
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 123 bits (308), Expect = 1e-27
Identities = 87/247 (35%), Positives = 132/247 (53%), Gaps = 27/247 (10%)
Query: 813 EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIV 868
EK E QAY LL+ ILP VA +R + + ++ + V + F+ I
Sbjct: 1025 EKEEMEELQAYNRR------LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 1078
Query: 869 GFTA----LSAESTPMQVVTLLNDLYTCFDAII--DNF-DVYKVETIGDAYMVVSGLPGR 921
F+ L A + ++ + LLN++ FD II D F + K++TIG YM SGL
Sbjct: 1079 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDS 1138
Query: 922 N----GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRY 977
G+ H +A A+ L+D + I + +++IG++ GPV AGV+G + P+Y
Sbjct: 1139 TYDKVGKTHIKALADFAMKLMDQMKY--INEHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1196
Query: 978 CLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037
++G+TVN ASRM+S G +I V++ L +QLE RG V++KGKG+M TY+L
Sbjct: 1197 DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL-AANTYQLECRGVVKVKGKGEMMTYFLN 1255
Query: 1038 GERKGPP 1044
G GPP
Sbjct: 1256 G---GPP 1259
Score = 103 bits (258), Expect = 6e-22
Identities = 63/204 (30%), Positives = 111/204 (54%), Gaps = 18/204 (8%)
Query: 826 EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSVTIYFSDIVGFTALSA 875
E ++ E LL +LP VA ++K + E D+V+I F+DI GFT+L++
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
Query: 876 ESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMAL 935
+ T ++V LN+L+ FD + +++ +GD Y VSGLP HA M +
Sbjct: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
Query: 936 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 995
+++A+S +R + +R+G+H+G V GV+GL+ ++ ++ + V A+ ME+ G+
Sbjct: 543 DMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
Query: 996 ALKIHVSSTTKDALD-----ELGC 1014
A +IH++ T + L+ E GC
Sbjct: 601 AGRIHITKATLNYLNGDYEVEPGC 624
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 120 bits (301), Expect = 7e-27
Identities = 88/270 (32%), Positives = 140/270 (51%), Gaps = 28/270 (10%)
Query: 801 LLLRMEQYANNLEKLVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL----KRGETV 852
+L R +Y L+ L +++ + EE E LL +LP VA Q +R E +
Sbjct: 805 VLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDL 864
Query: 853 QAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAIIDN---FDVYKV 905
++++ V + F+ + F +ES ++ + LLN++ FD ++ V K+
Sbjct: 865 YHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKI 924
Query: 906 ETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFR---------IRHRPHDQLRL 956
+TIG YM +GL +GQ A + A + + L + F I + RL
Sbjct: 925 KTIGSTYMAATGLNATSGQ-DAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRL 983
Query: 957 RIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQ 1016
R+G++ GPV AGV+G + P+Y ++G+TVN ASRMES G KI V+ T AL LG +
Sbjct: 984 RVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLG-YT 1042
Query: 1017 LELRGDVEMKGKGKMRTYWLLGE--RKGPP 1044
RG +++KGKG++ TY+L + R GPP
Sbjct: 1043 CYSRGVIKVKGKGQLCTYFLNTDLTRTGPP 1072
Score = 102 bits (254), Expect = 2e-21
Identities = 62/203 (30%), Positives = 108/203 (53%), Gaps = 4/203 (1%)
Query: 804 RMEQYANNLEKLVEERTQAYLEEKRKAEALL-YQILPHSVAEQLKRGETVQAEAFDSVTI 862
R++ + E L+ AYL + KAE + Q S E ++ + V++
Sbjct: 215 RLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSV 274
Query: 863 YFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRN 922
++DIVGFT L++E +P ++V +LN+L+ FD I + +++ +GD Y VSGLP +
Sbjct: 275 LYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP-LS 333
Query: 923 GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGD 982
HA RM L + A+ ++R + +R+GVH+G V GV+GL+ +Y ++
Sbjct: 334 LPDHAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSH 391
Query: 983 TVNTASRMESNGQALKIHVSSTT 1005
V A+ ME+ G ++H++ T
Sbjct: 392 DVTLANHMEAGGVPGRVHITGAT 414
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 119 bits (298), Expect = 1e-26
Identities = 84/279 (30%), Positives = 143/279 (51%), Gaps = 41/279 (14%)
Query: 801 LLLRMEQYANNLEKL----------VEERTQAYLEEKRKAEALLYQILPHSVAEQL---- 846
++L ++ ++EKL V ++ + E +R EAL+ +LP VA
Sbjct: 849 MMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSK 908
Query: 847 KRGETVQAEAFDSVTIYFSDIVGF----TALSAESTPMQVVTLLNDLYTCFDAIIDNFD- 901
KR E + ++ +D + + F+ + F T S + ++ + LN++ + FD+++DN
Sbjct: 909 KRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKF 968
Query: 902 --VYKVETIGDAYMVVSGLPG-----------------RNGQRHAPEIARMALALLDAVS 942
+ K++TIG YM SG+ R +H ++A ALA+ D ++
Sbjct: 969 RVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLT 1028
Query: 943 SFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVS 1002
+ I ++ + LRIG++ G V AGV+G + P Y ++G+TVN ASRMES G I V
Sbjct: 1029 N--INNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVV 1086
Query: 1003 STTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERK 1041
T+ L E G F+ RG + +KGKG++ T++L G K
Sbjct: 1087 EETQVILREYG-FRFVRRGPIFVKGKGELLTFFLKGRDK 1124
Score = 109 bits (272), Expect = 2e-23
Identities = 65/198 (32%), Positives = 112/198 (56%), Gaps = 16/198 (8%)
Query: 825 EEKRKAEALLYQILPHSVAEQL----KRGE---------TVQAEAFDSVTIYFSDIVGFT 871
E+ ++ E L+ ILP VA+++ K+ E T+ ++V+I F+DIVGFT
Sbjct: 270 EQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT 329
Query: 872 ALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIA 931
LS+ + ++V LLN+L+ FD + + +++ +GD Y + GLP + HA
Sbjct: 330 QLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYR-EDHAVCSI 388
Query: 932 RMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRME 991
M LA+++A+S +R + + +R+GVHTG V GV+G K +Y ++ V A++ME
Sbjct: 389 LMGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKME 446
Query: 992 SNGQALKIHVSSTTKDAL 1009
+ G ++H+S +T D L
Sbjct: 447 AGGIPGRVHISQSTMDCL 464
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 119 bits (297), Expect = 2e-26
Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 24/241 (9%)
Query: 813 EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIV 868
EK E QAY LL+ ILP VA +R + + ++ + V + F+ I
Sbjct: 933 EKEEMEELQAYNRR------LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 986
Query: 869 GFTA----LSAESTPMQVVTLLNDLYTCFDAIIDNF---DVYKVETIGDAYMVVSGLPGR 921
F+ L A + ++ + LLN++ FD II + K++TIG YM SGL
Sbjct: 987 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNAS 1046
Query: 922 N----GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRY 977
G+ H +A A+ L++ + I + +++IG++ GPV AGV+G + P+Y
Sbjct: 1047 TYDQVGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1104
Query: 978 CLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037
++G+TVN +SRM+S G +I V++ L G +QLE RG V++KGKG+M TY+L
Sbjct: 1105 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMTTYFLN 1163
Query: 1038 G 1038
G
Sbjct: 1164 G 1164
Score = 106 bits (264), Expect = 1e-22
Identities = 70/237 (29%), Positives = 124/237 (52%), Gaps = 31/237 (13%)
Query: 818 ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 860
+ T+ Y++ E R+ E LL +LP VA ++K + E D+V
Sbjct: 319 QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
Query: 861 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920
+I F+DI GFT+L+++ T ++V LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 379 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
Query: 921 RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
HA M + +++A+S +R + +R+G+H+G V GV+GL+ ++ ++
Sbjct: 439 ARAD-HAHCCVEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW 495
Query: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMK-GKGKMRTYWL 1036
+ V A+ ME+ G+A +IH++ T L+ GD E++ G+G R +L
Sbjct: 496 SNDVTLANHMEAGGRAGRIHITRATLQYLN----------GDYEVEPGRGGERNAYL 542
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 119 bits (297), Expect = 2e-26
Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 24/241 (9%)
Query: 813 EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIV 868
EK E QAY LL+ ILP VA +R + + ++ + V + F+ I
Sbjct: 880 EKEEMEELQAYNRR------LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 933
Query: 869 GFTA----LSAESTPMQVVTLLNDLYTCFDAIIDNF---DVYKVETIGDAYMVVSGLPGR 921
F+ L A + ++ + LLN++ FD II + K++TIG YM SGL
Sbjct: 934 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNAS 993
Query: 922 N----GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRY 977
G+ H +A A+ L++ + I + +++IG++ GPV AGV+G + P+Y
Sbjct: 994 TYDQVGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1051
Query: 978 CLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037
++G+TVN +SRM+S G +I V++ L G +QLE RG V++KGKG+M TY+L
Sbjct: 1052 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMTTYFLN 1110
Query: 1038 G 1038
G
Sbjct: 1111 G 1111
Score = 106 bits (264), Expect = 1e-22
Identities = 70/237 (29%), Positives = 124/237 (52%), Gaps = 31/237 (13%)
Query: 818 ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 860
+ T+ Y++ E R+ E LL +LP VA ++K + E D+V
Sbjct: 319 QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
Query: 861 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920
+I F+DI GFT+L+++ T ++V LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 379 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
Query: 921 RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
HA M + +++A+S +R + +R+G+H+G V GV+GL+ ++ ++
Sbjct: 439 ARAD-HAHCCVEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW 495
Query: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMK-GKGKMRTYWL 1036
+ V A+ ME+ G+A +IH++ T L+ GD E++ G+G R +L
Sbjct: 496 SNDVTLANHMEAGGRAGRIHITRATLQYLN----------GDYEVEPGRGGERNAYL 542
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 118 bits (295), Expect = 3e-26
Identities = 84/251 (33%), Positives = 135/251 (53%), Gaps = 23/251 (9%)
Query: 817 EERTQAYLEEKRKAEALLYQILPHSVA----EQLKRGETVQAEAFDSVTIYFSDIVGFTA 872
+E E + E +L ILP VA E+ + E + ++++D+V + F+ I GF
Sbjct: 934 KEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFAD 993
Query: 873 LSAESTP----MQVVTLLNDLYTCFDAII--DNF-DVYKVETIGDAYMVVSGLPGRNGQ- 924
+++ ++ + LLN++ FD ++ D F D+ K++TIG YM VSGL Q
Sbjct: 994 FYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQC 1053
Query: 925 ----RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
H +A +LAL +++ I + LRIG+ G V AGV+G K P+Y ++
Sbjct: 1054 EDKWGHLCALADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIW 1111
Query: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG----KGKMRTYWL 1036
G TVN ASRM+S G + +I V T L + G F + RG++ +KG +GK++TY+L
Sbjct: 1112 GKTVNLASRMDSTGVSGRIQVPEETYLILKDQG-FAFDYRGEIYVKGISEQEGKIKTYFL 1170
Query: 1037 LGERKGPPGLL 1047
LG + P +L
Sbjct: 1171 LGRVQPNPFIL 1181
Score = 101 bits (251), Expect = 4e-21
Identities = 71/236 (30%), Positives = 123/236 (52%), Gaps = 26/236 (11%)
Query: 814 KLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGET-------------VQAEAFDSV 860
+ VE R + E +R+ E L+ +LP V ++ T + +++V
Sbjct: 355 RCVEARLRLETENQRQ-ERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENV 413
Query: 861 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920
+I F+D+ GFT LS + ++V +LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 414 SILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLP- 472
Query: 921 RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
Q HA M L+++ + R R + HD + +RIG+H+G V GV+GL+ ++ ++
Sbjct: 473 EPRQDHAHCCVEMGLSMIKTIRYVRSRTK-HD-VDMRIGIHSGSVLCGVLGLRKWQFDVW 530
Query: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
V+ A+++ES G +IH+S T D L+ G + +E +G GK R +L
Sbjct: 531 SWDVDIANKLESGGIPGRIHISKATLDCLN--GDYNVE-------EGHGKERNEFL 577
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 113 bits (282), Expect = 1e-24
Identities = 82/258 (31%), Positives = 130/258 (50%), Gaps = 26/258 (10%)
Query: 802 LLRMEQYANNLEKLVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL---KRGETVQA 854
L R Y L+ L +++ + EE E LL +LP VA K E
Sbjct: 813 LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYH 872
Query: 855 EAFDSVTIYFSDI----VGFTALSAESTPMQVVTLLNDLYTCFDAII--DNFD-VYKVET 907
+++D V + F+ + V +T ++ + LLN++ FD ++ F V K++T
Sbjct: 873 QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
Query: 908 IGDAYMVVSGLPGRNGQR---------HAPEIARMALALLDAVSSFRIRHRPHDQLRLRI 958
IG YM +GL +G H + ++AL+ + I + RLR+
Sbjct: 933 IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDG--INRHSFNSFRLRV 990
Query: 959 GVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLE 1018
G++ GPV AGV+G + P+Y ++G+TVN ASRMES G+ KI V+ T L LG + E
Sbjct: 991 GINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLG-YSCE 1049
Query: 1019 LRGDVEMKGKGKMRTYWL 1036
RG + +KGKG++RTY++
Sbjct: 1050 CRGLINVKGKGELRTYFV 1067
Score = 103 bits (256), Expect = 1e-21
Identities = 70/242 (28%), Positives = 129/242 (53%), Gaps = 29/242 (11%)
Query: 826 EKRKAEALLYQILPHSVA--------EQLKRG-----------ETVQAEAFDSVTIYFSD 866
EKR+ E LL +LP ++ E+LK ++ + +V+I ++D
Sbjct: 225 EKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYAD 284
Query: 867 IVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRH 926
IVGFT L+++ +P ++V +LN+L+ FD I + +++ +GD Y VSGLP + H
Sbjct: 285 IVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLP-VSLPTH 343
Query: 927 APEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNT 986
A +M L + A+ ++R + +R+G+H+G V GV+GL+ +Y ++ V+
Sbjct: 344 ARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSL 401
Query: 987 ASRMESNGQALKIHVSSTTKDALDELGCFQLE----LRGDVEMKGKGKMRTYWLLGERKG 1042
A+RME+ G ++H++ T LD+ +++E + D +K + +RTY ++ R
Sbjct: 402 ANRMEAAGVPGRVHITEATLKHLDK--AYEVEDGHGQQRDPYLK-EMNIRTYLVIDPRSQ 458
Query: 1043 PP 1044
P
Sbjct: 459 QP 460
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 113 bits (282), Expect = 1e-24
Identities = 82/261 (31%), Positives = 130/261 (49%), Gaps = 28/261 (10%)
Query: 801 LLLRMEQYANNLEKLVEERTQAYLEEKRKAE----ALLYQILPHSVAEQLK----RGETV 852
+L R +Y L+ L + + + EE E LL +LP VAE + E +
Sbjct: 819 VLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEEL 878
Query: 853 QAEAFDSVTIYFSDIVGFTALSAESTP----MQVVTLLNDLYTCFDAIIDN---FDVYKV 905
+++D V + F+ I F ES ++ + LLN++ FD ++ V K+
Sbjct: 879 YHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKI 938
Query: 906 ETIGDAYMVVSGLPGRNGQRHAPEIARM----------ALALLDAVSSFRIRHRPHDQLR 955
+TIG YM +GL Q H+ E R A AL+ + + I + +
Sbjct: 939 KTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDA--INKHSFNDFK 996
Query: 956 LRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCF 1015
LR+G++ GPV AGV+G + P+Y ++G+TVN ASRM+S G KI V+ T L LG +
Sbjct: 997 LRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLG-Y 1055
Query: 1016 QLELRGDVEMKGKGKMRTYWL 1036
RG + +KGKG ++TY++
Sbjct: 1056 TCTCRGIINVKGKGDLKTYFV 1076
Score = 112 bits (280), Expect = 2e-24
Identities = 75/248 (30%), Positives = 136/248 (54%), Gaps = 34/248 (13%)
Query: 826 EKRKAEALLYQILPHSVAEQLKRGETVQ--------------------AEAFDSVTIYFS 865
EKR+ E LL +LP +A ++K E +Q + +V+I ++
Sbjct: 236 EKRQQERLLLSLLPAHIAMEMK-AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYA 294
Query: 866 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQR 925
DIVGFT L+++ +P ++V +LN+L+ FD I + +++ +GD Y VSGLP +
Sbjct: 295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP-ISLPN 353
Query: 926 HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN 985
HA +M L + +A+ ++R + +R+GVH+G V GV+GL+ +Y ++ V
Sbjct: 354 HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
Query: 986 TASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG----KGKMRTYWLL---G 1038
A+ ME+ G ++H+SS T + L+ G +++E GD +++ + ++TY+++ G
Sbjct: 412 LANHMEAGGVPGRVHISSVTLEHLN--GAYKVE-EGDGDIRDPYLKQHLVKTYFVINPKG 468
Query: 1039 ERKGPPGL 1046
ER+ P L
Sbjct: 469 ERRSPQHL 476
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 111 bits (278), Expect = 3e-24
Identities = 75/217 (34%), Positives = 117/217 (53%), Gaps = 14/217 (6%)
Query: 829 KAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP--MQVVTLL 886
+A+ LL I+P+ VAEQLK +T ++ DS + F+ IV F+ E+ + +L
Sbjct: 1027 QADWLLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVL 1085
Query: 887 NDLYTCFDAIIDNFD---VYKVETIGDAYMVVSGL------PGRNGQRHAPEIARMALAL 937
N+L FD ++ D + K++TIG YM SGL G + Q H + A +
Sbjct: 1086 NELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEM 1145
Query: 938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAL 997
+ V F + +LR+G + GP+ AGV+G Y ++GDTVN ASRM++ G
Sbjct: 1146 MRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
Query: 998 KIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTY 1034
+I VS + L ++G + + RG V +KGKG+M+TY
Sbjct: 1205 RIQVSEESYRVLSKMG-YDFDYRGTVNVKGKGQMKTY 1240
Score = 103 bits (258), Expect = 6e-22
Identities = 62/193 (32%), Positives = 104/193 (53%), Gaps = 12/193 (6%)
Query: 855 EAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMV 914
+ + V+I F+DIVGFT +SA + +V LLNDL+ FD + + K+ T+GD Y
Sbjct: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
Query: 915 VSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKM 974
V+G P HA M L ++ A+ F + + +R+GVHTG V G++G++
Sbjct: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQF--CQEKKEMVNMRVGVHTGTVLCGILGMRR 504
Query: 975 PRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKG----- 1029
++ ++ + VN A+ ME G A K+H+S T LD+ +++E +E G+
Sbjct: 505 FKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR--YEMEDGKVIERLGQSVVADQ 562
Query: 1030 --KMRTYWLLGER 1040
++TY + G+R
Sbjct: 563 LKGLKTYLISGQR 575
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 111 bits (277), Expect = 4e-24
Identities = 76/262 (29%), Positives = 134/262 (51%), Gaps = 26/262 (9%)
Query: 800 NLLLRMEQ-YANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQA 854
++ LR++ +A E+ E+ + L+ +R +L+ +LP VA+ R +
Sbjct: 806 DIRLRLDYLWAAQAEEEREDMEKVKLDNRR----ILFNLLPAHVAQHFLMSNPRNMDLYY 861
Query: 855 EAFDSVTIYFSDIVGFT----ALSAESTPMQVVTLLNDLYTCFDAIIDNF---DVYKVET 907
+++ V + F+ I F L + ++ + LLN++ FD +++ D+ K++T
Sbjct: 862 QSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKT 921
Query: 908 IGDAYMVVSGLPGRNGQR-------HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV 960
IG YM GL +G + H +A A+ + D + I ++ ++ LR+G+
Sbjct: 922 IGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDE--INYQSYNDFVLRVGI 979
Query: 961 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR 1020
+ GPV AGV+G + P+Y ++G+TVN ASRM+S G +I V+ L + R
Sbjct: 980 NVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP-YHFVCR 1038
Query: 1021 GDVEMKGKGKMRTYWLLGERKG 1042
G V +KGKG+M TY+L G G
Sbjct: 1039 GKVSVKGKGEMLTYFLEGRTDG 1060
Score = 110 bits (274), Expect = 9e-24
Identities = 73/222 (32%), Positives = 118/222 (53%), Gaps = 23/222 (10%)
Query: 825 EEKRKAEALLYQILPHSVAEQLKRG---------ETVQAEAFDSVTIYFSDIVGFTALSA 875
+E K E LL +LP +VA ++K + + D+V+I F+DIVGFT L++
Sbjct: 258 DENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLAS 317
Query: 876 ESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMAL 935
+ T ++V LLN+L+ FD + +++ +GD Y VSGL + HA M L
Sbjct: 318 QCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLT-QPKTDHAHCCVEMGL 376
Query: 936 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 995
++D ++S + L +R+G+HTG V GV+GL+ +Y ++ + V A+ ME+ G
Sbjct: 377 DMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGL 434
Query: 996 ALKIHVSSTTKDALDELGCFQLELRGDVEMK-GKGKMRTYWL 1036
K+H++ TT L C L GD E++ G G R +L
Sbjct: 435 PGKVHITKTT------LAC----LNGDYEVEPGYGHERNSFL 466
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 99.8 bits (247), Expect = 1e-20
Identities = 77/282 (27%), Positives = 135/282 (47%), Gaps = 22/282 (7%)
Query: 507 YHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQ-VL 565
YHK A R RG+S H +++ H H++ ++ R+ VL
Sbjct: 15 YHKLADLRYLS--RGASGTVSSARHADWRVQVAVKHL--------HIHTPLLDSERKDVL 64
Query: 566 FELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDIL--ENDSINLDWMFRYSL 623
E + + +F+++ +G C +P + IVTEY P GSL ++L + + ++ W R+ +
Sbjct: 65 REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRI 124
Query: 624 INDLVKGMAFLHNSIIS-SHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYA 682
++++ G+ +LHN H LK+ N ++D+ F +KI D+GL+ +R + + A
Sbjct: 125 LHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSA 184
Query: 683 KKLWTAPELLSGNPLP---TTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQK 739
+ T + N P + K D+YS+ +I E+ R PF E + +P +I+
Sbjct: 185 PEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF--EDV-TNPLQIMYS 241
Query: 740 VRNGQRPYFRPSIDRTQL--NEELVLLMERCWAQDPAERPDF 779
V G RP + ++ L+E WAQ+P ERP F
Sbjct: 242 VSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSF 283
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 98.6 bits (244), Expect = 3e-20
Identities = 92/310 (29%), Positives = 140/310 (45%), Gaps = 38/310 (12%)
Query: 548 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD- 606
VA+K + K IE ++L L H +QF G ++PPN IVTEY GSL D
Sbjct: 42 VAVKKLLK--IEKEAEILSVLSHRNIIQF------YGVILEPPNYGIVTEYASLGSLYDY 93
Query: 607 ILENDSINLDWMFRYSLINDLVKGMAFLHNS--IISSHGSLKSSNCVVDSRFVLKITDYG 664
I N S +D + D+ KGM +LH + H LKS N V+ + VLKI D+G
Sbjct: 94 INSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG 153
Query: 665 LASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF 724
+ F + +L W APE++ P+ T D YS+G++L E+ R PF
Sbjct: 154 ASRFHNHT---THMSLVGTFPWMAPEVIQSLPVSET----CDTYSYGVVLWEMLTREVPF 206
Query: 725 Y-LEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIK 783
LEGL ++ +V+K P P L+ +CW D +RP F QI
Sbjct: 207 KGLEGLQVA-WLVVEKNERLTIPSSCP--------RSFAELLHQCWEADAKKRPSFKQII 257
Query: 784 GFIRRFNKEGGTSILD---NLLLRMEQYANNLEKLVE-----ERTQAYLEEKRKAEALLY 835
+ + + TS+ D + L ++ +E +E ER ++ E++ K
Sbjct: 258 SILESMSND--TSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRL 315
Query: 836 QILPHSVAEQ 845
++ + EQ
Sbjct: 316 KMWEQKLTEQ 325
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 98.6 bits (244), Expect = 3e-20
Identities = 92/310 (29%), Positives = 140/310 (45%), Gaps = 38/310 (12%)
Query: 548 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD- 606
VA+K + K IE ++L L H +QF G ++PPN IVTEY GSL D
Sbjct: 42 VAVKKLLK--IEKEAEILSVLSHRNIIQF------YGVILEPPNYGIVTEYASLGSLYDY 93
Query: 607 ILENDSINLDWMFRYSLINDLVKGMAFLHNS--IISSHGSLKSSNCVVDSRFVLKITDYG 664
I N S +D + D+ KGM +LH + H LKS N V+ + VLKI D+G
Sbjct: 94 INSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG 153
Query: 665 LASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF 724
+ F + +L W APE++ P+ T D YS+G++L E+ R PF
Sbjct: 154 ASRFHNHT---THMSLVGTFPWMAPEVIQSLPVSET----CDTYSYGVVLWEMLTREVPF 206
Query: 725 Y-LEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIK 783
LEGL ++ +V+K P P L+ +CW D +RP F QI
Sbjct: 207 KGLEGLQVA-WLVVEKNERLTIPSSCP--------RSFAELLHQCWEADAKKRPSFKQII 257
Query: 784 GFIRRFNKEGGTSILD---NLLLRMEQYANNLEKLVE-----ERTQAYLEEKRKAEALLY 835
+ + + TS+ D + L ++ +E +E ER ++ E++ K
Sbjct: 258 SILESMSND--TSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRL 315
Query: 836 QILPHSVAEQ 845
++ + EQ
Sbjct: 316 KMWEQKLTEQ 325
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/219 (31%), Positives = 111/219 (50%), Gaps = 17/219 (7%)
Query: 567 ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLIND 626
E M+ ++F H+ G C P + IV E+ GSL+ +L S L W R+ +I++
Sbjct: 71 EAAKMKKIKFQHIVSIYGVCKQP--LGIVMEFMANGSLEKVLSTHS--LCWKLRFRIIHE 126
Query: 627 LVKGMAFLHN-SIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTA---EPDDSHALYA 682
M FLH+ H LK N ++DS +KI+D+GL+ + + + + AL
Sbjct: 127 TSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRG 186
Query: 683 KKLWTAPEL-LSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVR 741
+ PE+ L N P K DVYSF I++ E+ + P+ G ++ I+ +V
Sbjct: 187 MLSYIPPEMFLESNKAPGP---KYDVYSFAIVIWELLTQKKPY--SGFNMMM--IIIRVA 239
Query: 742 NGQRPYFRPSIDRTQLN-EELVLLMERCWAQDPAERPDF 779
G RP +P D+ +++V LM+RCW QDP +RP F
Sbjct: 240 AGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCF 278
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 92.4 bits (228), Expect = 2e-18
Identities = 75/234 (32%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 554 NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSI 613
+++R+EL L E K M +F ++ G C +P + +V EY GSL+ +L ++
Sbjct: 60 DRERMEL----LEEAKKMEMAKFRYILPVYGICREP--VGLVMEYMETGSLEKLLASEP- 112
Query: 614 NLDWMFRYSLINDLVKGMAFLHNSIISS-HGSLKSSNCVVDSRFVLKITDYGLASFRSTA 672
L W R+ +I++ GM FLH H LK +N ++D+ + +KI+D+GLA +
Sbjct: 113 -LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLS 171
Query: 673 EPDD--SHALYAKKLWTAPELL-SGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGL 729
D L+ + PE + + L T K DVYSF I++ + + PF E
Sbjct: 172 HSHDLSMDGLFGTIAYLPPERIREKSRLFDT---KHDVYSFAIVIWGVLTQKKPFADEKN 228
Query: 730 DLSPKEIVQKVRNGQRPYFRPSID-RTQLNEELVLLMERCWAQDPAERPDFGQI 782
L I+ KV G RP P R + L+ LM+RCW DP RP F +I
Sbjct: 229 IL---HIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEI 279
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 92.0 bits (227), Expect = 3e-18
Identities = 80/294 (27%), Positives = 139/294 (47%), Gaps = 49/294 (16%)
Query: 558 IELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDW 617
IE +L E K M ++ + + + +G I+ +V EY +G+L +L+ + ++
Sbjct: 54 IEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAE-MSTPL 112
Query: 618 MFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR--STAEPD 675
+ +I ++++GM +LH + H LK N +VD+ F +KI D GLASF+ S +
Sbjct: 113 SVKGRIILEIIEGMCYLHGKGVI-HKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE 171
Query: 676 DSHAL-----YAKK-----LWTAPELLSG-NPLPTTGMQKADVYSFGIILQEIALRSGPF 724
+ + L AKK + APE L+ N PT +K+DVYSF ++L I P+
Sbjct: 172 EHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPT---EKSDVYSFAVVLWAIFANKEPY 228
Query: 725 YLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNE----ELVLLMERCWAQDPAERPDFG 780
+ ++++ +++G RP D + E E++ LM+ CW +P RP F
Sbjct: 229 ENA---ICEQQLIMCIKSGNRP------DVDDITEYCPREIISLMKLCWEANPEARPTFP 279
Query: 781 QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALL 834
I+ R F Y + LE+ VEE ++ +E A++
Sbjct: 280 GIEEKFRPF------------------YLSQLEESVEEDVKSLKKEYSNENAVV 315
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,215,038
Number of Sequences: 37866
Number of extensions: 1891279
Number of successful extensions: 5098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 425
Number of HSP's that attempted gapping in prelim test: 4209
Number of HSP's gapped (non-prelim): 697
length of query: 1047
length of database: 18,247,518
effective HSP length: 113
effective length of query: 934
effective length of database: 13,968,660
effective search space: 13046728440
effective search space used: 13046728440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.