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Search of human proteins with 45643117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
(750 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 1510 0.0
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 1428 0.0
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 1030 0.0
gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 1030 0.0
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 971 0.0
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 115 1e-25
gi|93004081 polo-like kinase 2 [Homo sapiens] 115 1e-25
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 115 2e-25
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 112 2e-24
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 110 6e-24
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 109 1e-23
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 109 1e-23
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 108 2e-23
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 108 2e-23
gi|23308722 TTK protein kinase [Homo sapiens] 108 2e-23
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 107 3e-23
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 107 3e-23
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 107 3e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 107 3e-23
gi|121114283 polo-like kinase 4 [Homo sapiens] 107 4e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 106 7e-23
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 106 9e-23
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 105 1e-22
gi|83776600 aurora kinase B [Homo sapiens] 105 2e-22
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 104 3e-22
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 104 3e-22
>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
Length = 750
Score = 1510 bits (3909), Expect = 0.0
Identities = 750/750 (100%), Positives = 750/750 (100%)
Query: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
Sbjct: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
Query: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 120
RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL
Sbjct: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 120
Query: 121 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 180
PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
Sbjct: 121 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 180
Query: 181 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 240
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
Sbjct: 181 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 240
Query: 241 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 300
ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT
Sbjct: 241 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 300
Query: 301 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 360
TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
Sbjct: 301 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 360
Query: 361 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 420
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK
Sbjct: 361 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 420
Query: 421 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 480
RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE
Sbjct: 421 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 480
Query: 481 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 540
KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
Sbjct: 481 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 540
Query: 541 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 600
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD
Sbjct: 541 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 600
Query: 601 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 660
DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG
Sbjct: 601 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 660
Query: 661 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720
HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL
Sbjct: 661 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720
Query: 721 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 750
PHIRKSVSTSSPAGAAIASTSGASNNSSSN
Sbjct: 721 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 750
>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
Length = 718
Score = 1428 bits (3697), Expect = 0.0
Identities = 718/750 (95%), Positives = 718/750 (95%), Gaps = 32/750 (4%)
Query: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
Sbjct: 1 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 60
Query: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 120
RNRKRKAEPYETSQGKGTPRGHKISDYFE
Sbjct: 61 RNRKRKAEPYETSQGKGTPRGHKISDYFE------------------------------- 89
Query: 121 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 180
RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
Sbjct: 90 -RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 148
Query: 181 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 240
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
Sbjct: 149 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 208
Query: 241 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 300
ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT
Sbjct: 209 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 268
Query: 301 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 360
TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
Sbjct: 269 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 328
Query: 361 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 420
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK
Sbjct: 329 KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELK 388
Query: 421 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 480
RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE
Sbjct: 389 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDE 448
Query: 481 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 540
KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
Sbjct: 449 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 508
Query: 541 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 600
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD
Sbjct: 509 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 568
Query: 601 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 660
DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG
Sbjct: 569 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 628
Query: 661 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720
HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL
Sbjct: 629 HNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 688
Query: 721 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 750
PHIRKSVSTSSPAGAAIASTSGASNNSSSN
Sbjct: 689 PHIRKSVSTSSPAGAAIASTSGASNNSSSN 718
>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
Length = 718
Score = 1030 bits (2664), Expect = 0.0
Identities = 551/773 (71%), Positives = 606/773 (78%), Gaps = 88/773 (11%)
Query: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE
Sbjct: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
Query: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPP 106
ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE+ GG+ G+SP R
Sbjct: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG--- 115
Query: 107 VARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQ 166
+P + P ++ +T S P
Sbjct: 116 -------------IPPAIRSPQ-----NSHSHSTPSSSVRP------------------- 138
Query: 167 RGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNS 226
NSPS T +H KQ+S + QT DLT+ K++ALE++K
Sbjct: 139 --------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQ 182
Query: 227 DLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACR 286
DLEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R
Sbjct: 183 DLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSR 242
Query: 287 DKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRK 346
+KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRK
Sbjct: 243 EKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRK 302
Query: 347 PPAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHL 394
PP QAP +E KQRK+K NGAEN+ LTLAEYHEQEEIFKLRLGHL
Sbjct: 303 PPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHL 362
Query: 395 KKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEV 454
KKEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEV
Sbjct: 363 KKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEV 422
Query: 455 YKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 514
YKAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD
Sbjct: 423 YKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 482
Query: 515 TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPG 574
TD+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPG
Sbjct: 483 TDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPG 542
Query: 575 NILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPP 634
NILLV+GTACGEIKITDFGLSKIMDDDSY VDGM+LTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 543 NILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPP 601
Query: 635 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKA 694
KISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKA
Sbjct: 602 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 661
Query: 695 FIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745
FIRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ + AG + T +S+
Sbjct: 662 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 714
>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
Length = 766
Score = 1030 bits (2664), Expect = 0.0
Identities = 551/773 (71%), Positives = 606/773 (78%), Gaps = 88/773 (11%)
Query: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE
Sbjct: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108
Query: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPP 106
ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE+ GG+ G+SP R
Sbjct: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG--- 163
Query: 107 VARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQ 166
+P + P ++ +T S P
Sbjct: 164 -------------IPPAIRSPQ-----NSHSHSTPSSSVRP------------------- 186
Query: 167 RGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNS 226
NSPS T +H KQ+S + QT DLT+ K++ALE++K
Sbjct: 187 --------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQ 230
Query: 227 DLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACR 286
DLEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R
Sbjct: 231 DLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSR 290
Query: 287 DKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRK 346
+KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRK
Sbjct: 291 EKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRK 350
Query: 347 PPAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHL 394
PP QAP +E KQRK+K NGAEN+ LTLAEYHEQEEIFKLRLGHL
Sbjct: 351 PPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHL 410
Query: 395 KKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEV 454
KKEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEV
Sbjct: 411 KKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEV 470
Query: 455 YKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 514
YKAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD
Sbjct: 471 YKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 530
Query: 515 TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPG 574
TD+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPG
Sbjct: 531 TDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPG 590
Query: 575 NILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPP 634
NILLV+GTACGEIKITDFGLSKIMDDDSY VDGM+LTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 591 NILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPP 649
Query: 635 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKA 694
KISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKA
Sbjct: 650 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 709
Query: 695 FIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745
FIRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ + AG + T +S+
Sbjct: 710 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 762
>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
Length = 670
Score = 971 bits (2509), Expect = 0.0
Identities = 514/712 (72%), Positives = 566/712 (79%), Gaps = 76/712 (10%)
Query: 51 ETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPPV 107
+TPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE+ GG+ G+SP R
Sbjct: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG---- 67
Query: 108 ARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQR 167
+P + P ++ +T S P
Sbjct: 68 ------------IPPAIRSPQ-----NSHSHSTPSSSVRP-------------------- 90
Query: 168 GAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSD 227
NSPS T +H KQ+S + QT DLT+ K++ALE++K D
Sbjct: 91 -------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQD 135
Query: 228 LEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRD 287
LEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R+
Sbjct: 136 LEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSRE 195
Query: 288 KSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKP 347
KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRKP
Sbjct: 196 KSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKP 255
Query: 348 PAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHLK 395
P QAP +E KQRK+K NGAEN+ LTLAEYHEQEEIFKLRLGHLK
Sbjct: 256 PTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLK 315
Query: 396 KEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVY 455
KEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVY
Sbjct: 316 KEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVY 375
Query: 456 KAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT 515
KAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT
Sbjct: 376 KAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT 435
Query: 516 DSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGN 575
D+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPGN
Sbjct: 436 DTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGN 495
Query: 576 ILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPK 635
ILLV+GTACGEIKITDFGLSKIMDDDSY VDGM+LTSQGAGTYWYLPPECFVVGKEPPK
Sbjct: 496 ILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPPK 554
Query: 636 ISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAF 695
ISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKAF
Sbjct: 555 ISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAF 614
Query: 696 IRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745
IRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ + AG + T +S+
Sbjct: 615 IRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 666
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 115 bits (289), Expect = 1e-25
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 25/287 (8%)
Query: 434 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 493
P D ++L LG G ++ VYKA+ + R V K+ EN E
Sbjct: 8 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63
Query: 494 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 553
I K + HP IV+L D F D+D+ ++E+C G DL ++ +++ EK AR + Q+
Sbjct: 64 EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122
Query: 554 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD-DSYNSVDGMELT 612
+AL++L+E I H DLKP NILL + +K+ DFG ++ M D + + G L
Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178
Query: 613 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 672
Y+ PE + +VD+WS+GVI Y+ L+G+ PF + E
Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223
Query: 673 TILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
I ++ P +P+++ + + ++R L RI Q P++
Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 270
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 115 bits (289), Expect = 1e-25
Identities = 89/292 (30%), Positives = 136/292 (46%), Gaps = 37/292 (12%)
Query: 434 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 493
PT RY +LG+GGF++ Y+ DLT + A KI ++ + ++E K E
Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131
Query: 494 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 553
+H+ L H +V+ Y YF D ++ +LEYC + LK K+++E E R + QIV
Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190
Query: 554 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTS 613
+ LKYL+E I+H DLK GN + E+K+ DFGL+ ++ +
Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFI---NEAMELKVGDFGLAARLEPLEHR-------RR 238
Query: 614 QGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT 673
GT YL PE V+ K+ + D+W++G + Y L GR PF E T
Sbjct: 239 TICGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETT 283
Query: 674 ILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 720
LK T E ++ + AK I L+ EDR + + + L
Sbjct: 284 NLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 115 bits (287), Expect = 2e-25
Identities = 97/317 (30%), Positives = 148/317 (46%), Gaps = 37/317 (11%)
Query: 445 LLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRI 504
L+G G F+ V+K E+ + V + +NK + + K E +I KEL H I
Sbjct: 21 LIGHGAFAVVFKGRH-REKHDLEVAVKCINKKNLAKSQTLLGK----EIKILKELKHENI 75
Query: 505 VKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKP 564
V LYD+ + +S V+EYC G DL YL + +SE R + QI A++ L+
Sbjct: 76 VALYDFQEM-ANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS--K 132
Query: 565 PIIHYDLKPGNILLVNGTACG------EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGT 618
IIH DLKP NILL N +KI DFG ++ + + + + G+
Sbjct: 133 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM--------MAATLCGS 184
Query: 619 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI---LQENTIL 675
Y+ PE + K D+WS+G I YQCL G+ PF S QD+ ++N L
Sbjct: 185 PMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNKTL 239
Query: 676 KATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL--LPHIRKSVSTSSPA 733
T P+ P + + L +DR+D + P+L P +RKS P+
Sbjct: 240 VPT----IPRETSAP-LRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPS 294
Query: 734 GAAIASTSGASNNSSSN 750
+ S S +S++S+S+
Sbjct: 295 YPSSGSGSSSSSSSTSH 311
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 112 bits (279), Expect = 2e-24
Identities = 90/296 (30%), Positives = 140/296 (47%), Gaps = 36/296 (12%)
Query: 419 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 478
+KR H++ N L RY L LG+G + +V +A + R VA+K + +K
Sbjct: 42 VKRHHHKHN--------LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI-- 91
Query: 479 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 538
K E H RE I L+HP I+ +Y+ F + D ++EY +L Y+ + +
Sbjct: 92 --KDEQDMVHIRREIEIMSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERR 148
Query: 539 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 598
+SE+E R QIV+A+ Y + K ++H DLK NILL + IKI DFGLS +
Sbjct: 149 RLSERETRHFFRQIVSAVHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLY 203
Query: 599 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 658
D + G+ Y PE V G+ P +VD W++GV+ Y +YG P
Sbjct: 204 QKDKF--------LQTFCGSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMP 252
Query: 659 FGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 714
F + I Q + + E + P +P +A+ IR L + R ++ +A
Sbjct: 253 FDGFDHKNLIRQ----ISSGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIA 301
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 110 bits (274), Expect = 6e-24
Identities = 96/311 (30%), Positives = 154/311 (49%), Gaps = 33/311 (10%)
Query: 426 DNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK-IHQLNKNWRDEKKEN 484
+ ++K + D Y +LG G FSEV A D Q+ VA+K I + ++ EN
Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65
Query: 485 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 544
E + ++ HP IV L D + + +++ G +L + + +E++
Sbjct: 66 -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117
Query: 545 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 604
A +I Q+++A+KYL+++ I+H DLKP N+L + +I I+DFGLSK+ D S
Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173
Query: 605 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 664
+ S GT Y+ PE V+ ++P S VD WS+GVI Y L G PF ++++
Sbjct: 174 ------VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEN 222
Query: 665 QQDILQENTILKAT-EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQ------LACDP 717
+ ++ ILKA E P ++ AK FIR + E R +Q +A D
Sbjct: 223 DAKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDT 280
Query: 718 YLLPHIRKSVS 728
L +I +SVS
Sbjct: 281 ALDKNIHQSVS 291
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 109 bits (272), Expect = 1e-23
Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%)
Query: 436 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 494
L D Y++ LG G EV AF+ + VA+KI K +E + + E
Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318
Query: 495 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 554
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376
Query: 555 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 614
A++YL+E IIH DLKP N+LL + IKITDFG SKI+ + S L
Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 426
Query: 615 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 674
GT YL PE +V + VD WS+GVI + CL G PF +++Q + + T
Sbjct: 427 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 484
Query: 675 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
+ + F P+ V+ +A +++ L + R ++ P+L
Sbjct: 485 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 109 bits (272), Expect = 1e-23
Identities = 90/287 (31%), Positives = 141/287 (49%), Gaps = 19/287 (6%)
Query: 436 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE-NYHKHACREYR 494
L D Y++ LG G EV AF+ + VA+KI K +E + + E
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
Query: 495 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVN 554
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333
Query: 555 ALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQ 614
A++YL+E IIH DLKP N+LL + IKITDFG SKI+ + S L
Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS--------LMRT 383
Query: 615 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI 674
GT YL PE +V + VD WS+GVI + CL G PF +++Q + + T
Sbjct: 384 LCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT- 441
Query: 675 LKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
+ + F P+ V+ +A +++ L + R ++ P+L
Sbjct: 442 --SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 108 bits (270), Expect = 2e-23
Identities = 96/297 (32%), Positives = 143/297 (48%), Gaps = 39/297 (13%)
Query: 419 LKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWR 478
+KR H++ N L RY L LG+G + +V KA + + R VA+K + +K
Sbjct: 40 VKRHHHKHN--------LRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKI-- 88
Query: 479 DEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK 538
K E H RE I L+HP I+ +++ F ++ V+EY DL Y+ + +
Sbjct: 89 --KDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE-NSSKIVIVMEYASRGDLYDYISERQ 145
Query: 539 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 598
+SE+EAR QIV+A+ Y ++ + ++H DLK NILL A G IKI DFGLS +
Sbjct: 146 QLSEREARHFFRQIVSAVHYCHQNR--VVHRDLKLENILL---DANGNIKIADFGLSNLY 200
Query: 599 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 658
+ G+ Y PE V GK P +VD WS+GV+ Y ++G P
Sbjct: 201 HQGKF--------LQTFCGSPLYASPE-IVNGK--PYTGPEVDSWSLGVLLYILVHGTMP 249
Query: 659 F-GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA 714
F GH+ IL + + + PPKP +A IR L R ++ +A
Sbjct: 250 FDGHDHK---ILVKQ--ISNGAYREPPKP---SDACGLIRWLLMVNPTRRATLEDVA 298
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 108 bits (270), Expect = 2e-23
Identities = 88/300 (29%), Positives = 142/300 (47%), Gaps = 26/300 (8%)
Query: 421 RIHNEDNSQFKDHPT-LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRD 479
R +D S +K T + ++ + +LG G FSEV+ + A+K + + +RD
Sbjct: 3 RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62
Query: 480 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL 539
EN E + K++ H IV L D + T + V++ G +L + + +
Sbjct: 63 SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114
Query: 540 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 599
+EK+A +I Q+++A+KYL+E I+H DLKP N+L + +I ITDFGLSK+
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172
Query: 600 DDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 659
+ + S GT Y+ PE V+ ++P S VD WS+GVI Y L G PF
Sbjct: 173 NG---------IMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF 219
Query: 660 GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
+ + L E E + P ++ AK FI L +R ++ P++
Sbjct: 220 --YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>gi|23308722 TTK protein kinase [Homo sapiens]
Length = 857
Score = 108 bits (269), Expect = 2e-23
Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 37/292 (12%)
Query: 440 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 499
Y +L +G GG S+V++ + +Q Y A+K L + ++ ++Y ++ +
Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Query: 500 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 559
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
Query: 560 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 619
++ I+H DLKP N L+V+G +K+ DFG++ M D+ + V ++ GT
Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSVVKDSQV-----GTV 687
Query: 620 WYLPPECFVV-------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 672
Y+PPE GK KIS K DVWS+G I Y YG+ PF Q I+ +
Sbjct: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQI 741
Query: 673 TILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
+ L A E++FP P + + ++ CL + RI + +L PY+
Sbjct: 742 SKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 107 bits (268), Expect = 3e-23
Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)
Query: 446 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 505
LG+G F VY A VA+K+ L K+ +KE RE I L HP I+
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70
Query: 506 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 565
+LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K
Sbjct: 71 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127
Query: 566 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 625
+IH D+KP N+LL GE+KI DFG S ++ GT YLPPE
Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 175
Query: 626 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 682
E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F
Sbjct: 176 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 224
Query: 683 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 725
P + A+ I R L Y+ +R+ + Q+ P++ H R+
Sbjct: 225 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 107 bits (268), Expect = 3e-23
Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)
Query: 446 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 505
LG+G F VY A VA+K+ L K+ +KE RE I L HP I+
Sbjct: 30 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85
Query: 506 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 565
+LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K
Sbjct: 86 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142
Query: 566 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 625
+IH D+KP N+LL GE+KI DFG S ++ GT YLPPE
Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 190
Query: 626 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 682
E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F
Sbjct: 191 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 239
Query: 683 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 725
P + A+ I R L Y+ +R+ + Q+ P++ H R+
Sbjct: 240 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 107 bits (268), Expect = 3e-23
Identities = 89/283 (31%), Positives = 137/283 (48%), Gaps = 35/283 (12%)
Query: 446 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 505
LG+G F VY A VA+K+ L K+ +KE RE I L HP I+
Sbjct: 49 LGKGKFGNVYLARLKESHFIVALKV--LFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104
Query: 506 KLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 565
+LY+YF D +LEY +L L++ + + E+ +II ++ +AL Y ++ K
Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161
Query: 566 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 625
+IH D+KP N+LL GE+KI DFG S ++ GT YLPPE
Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWSVHTPSLRRKTM---------CGTLDYLPPE 209
Query: 626 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQENTILKATEVQF 682
E KVD+W +GV+ Y+ L G PF H+++ + IL+ +V+F
Sbjct: 210 MI----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRF 258
Query: 683 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 725
P + A+ I R L Y+ +R+ + Q+ P++ H R+
Sbjct: 259 PLS--MPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 107 bits (268), Expect = 3e-23
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 29/295 (9%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHK 497
++Y +L ++G G F VYK + VA+K + K R EK+ ++ RE I +
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKEL---RNLQREIEIMR 56
Query: 498 ELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALK 557
L HP IV + D F D + V +Y EG +L L+ + E + ++I Q+V+AL
Sbjct: 57 GLRHPNIVHMLDSFETDKE-VVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114
Query: 558 YLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 617
YL+ + I+H D+KP NILL G G IK+ DFG ++ M S + M LTS G
Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAM------STNTMVLTSI-KG 162
Query: 618 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKA 677
T Y+ PE +V + P + D+WSVG I Y+ G PF I Q +++
Sbjct: 163 TPLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILK 214
Query: 678 TEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSP 732
V++P ++P K F++ L R+ L P++ H+ + P
Sbjct: 215 DPVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGP 267
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 107 bits (267), Expect = 4e-23
Identities = 93/316 (29%), Positives = 148/316 (46%), Gaps = 40/316 (12%)
Query: 444 HLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPR 503
+LLG+G F+ VY+A + VA+K+ + K + E +IH +L HP
Sbjct: 16 NLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHCQLKHPS 71
Query: 504 IVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIIMQIVNALKYLNEI 562
I++LY+YF D++ VLE C +++ YLK K SE EAR + QI+ + YL+
Sbjct: 72 ILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS- 129
Query: 563 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLS---KIMDDDSYNSVDGMELTSQGAGTY 619
I+H DL N+LL IKI DFGL+ K+ + Y GT
Sbjct: 130 -HGILHRDLTLSNLLLTRNM---NIKIADFGLATQLKMPHEKHYTL----------CGTP 175
Query: 620 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE 679
Y+ PE + + + + DVWS+G +FY L GR PF + +NT+ K
Sbjct: 176 NYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTLNKVVL 225
Query: 680 VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK------SVSTSSPA 733
+ ++ EAK I + L DR+ + + P++ + +V S +
Sbjct: 226 ADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDS 285
Query: 734 GAAIASTSGASNNSSS 749
G A ST+ +++S+S
Sbjct: 286 GHATISTAITASSSTS 301
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 106 bits (265), Expect = 7e-23
Identities = 89/281 (31%), Positives = 133/281 (47%), Gaps = 30/281 (10%)
Query: 440 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 499
Y LL +G+G F++V A + R VA+KI + + + + RE RI K L
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPSSLQKLFREVRIMKGL 113
Query: 500 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 559
+HP IVKL++ + + V+EY ++ YL H M EKEAR+ QIV+A+ Y
Sbjct: 114 NHPNIVKLFEVIETEKTLYL-VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 172
Query: 560 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 619
++ I+H DLK N+LL A IKI DFG S N G+
Sbjct: 173 HQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS--------NEFTLGSKLDTFCGSP 219
Query: 620 WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTILKAT 678
Y PE F K +VD+WS+GVI Y + G PF GHN + L+E +
Sbjct: 220 PYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRGKY 273
Query: 679 EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
V F ++ + ++ +RR L R ++Q+ D ++
Sbjct: 274 RVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 106 bits (264), Expect = 9e-23
Identities = 84/277 (30%), Positives = 138/277 (49%), Gaps = 25/277 (9%)
Query: 446 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIV 505
LGRG F+ V K + A K + + +D + E H+ A E D+P ++
Sbjct: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELA----QDNPWVI 122
Query: 506 KLYDYFSLDTDSFCTVLEYCEGNDL--DFYLKQHKLMSEKEARSIIMQIVNALKYLNEIK 563
L++ + ++ VLEY G ++ + + EK+ + ++ QI+ + +L+
Sbjct: 123 NLHEVYETASEMIL-VLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHT-- 179
Query: 564 PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLP 623
++H DLKP NILL + + G+IKI DFGLS+I+ NS + E+ GT Y+
Sbjct: 180 RDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILK----NSEELREI----MGTPEYVA 231
Query: 624 PECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTI-LKATEVQF 682
PE ++ +P IS D+WS+GV+ Y L G PF N Q+ L + + L +E +F
Sbjct: 232 PE--ILSYDP--ISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEF 287
Query: 683 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
V++ A FIR L + EDR ++ P+L
Sbjct: 288 ---DVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 615
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 616 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 675
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 676 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 615
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 616 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 675
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 676 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 615
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 616 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 675
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 676 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 615
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 616 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 675
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 676 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 105 bits (263), Expect = 1e-22
Identities = 94/286 (32%), Positives = 135/286 (47%), Gaps = 29/286 (10%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNK-NWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + T + A KI K + RD +K RE RI
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIHQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQG- 615
++++ I+H DLKP N+LL + +K+ DFGL+ V G + G
Sbjct: 125 NHIHQ--HDIVHRDLKPENLLLASKCKGAAVKLADFGLA--------IEVQGEQQAWFGF 174
Query: 616 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL 675
AGT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +
Sbjct: 175 AGTPGYLSPE--VLRKDP--YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQ---I 226
Query: 676 KATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
KA FP VTPEAK I + L RI Q P++
Sbjct: 227 KAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 105 bits (261), Expect = 2e-22
Identities = 91/303 (30%), Positives = 147/303 (48%), Gaps = 38/303 (12%)
Query: 433 HPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACRE 492
H T++D + + LG+G F VY A + VA+K+ L K+ +KE RE
Sbjct: 71 HFTIDD-FEIGRPLGKGKFGNVYLAREKKSHFIVALKV--LFKS--QIEKEGVEHQLRRE 125
Query: 493 YRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 552
I L HP I++LY+YF D +LEY +L L++ E+ +I+ ++
Sbjct: 126 IEIQAHLHHPNILRLYNYF-YDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 184
Query: 553 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELT 612
+AL Y + K +IH D+KP N+LL GE+KI DFG S V L
Sbjct: 185 ADALMYCHGKK--VIHRDIKPENLLL---GLKGELKIADFGWS----------VHAPSLR 229
Query: 613 SQG-AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDI 668
+ GT YLPPE E + KVD+W +GV+ Y+ L G PF HN++ + I
Sbjct: 230 RKTMCGTLDYLPPEMI----EGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRI 285
Query: 669 LQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS 728
++ +++FP V A+ I + L + +R+ + Q++ P++ + R+ +
Sbjct: 286 VK-------VDLKFPAS--VPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLP 336
Query: 729 TSS 731
S+
Sbjct: 337 PSA 339
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 104 bits (260), Expect = 3e-22
Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + + T Q Y A I+ + RD +K RE RI
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 616
+ + I+H DLKP N+LL + + +K+ DFGL+ + D + A
Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175
Query: 617 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 676
GT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +K
Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227
Query: 677 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
A FP VTPEAK I + L RI + P++
Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 104 bits (260), Expect = 3e-22
Identities = 91/285 (31%), Positives = 134/285 (47%), Gaps = 27/285 (9%)
Query: 438 DRYLLLHLLGRGGFSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 496
D Y L LG+G FS V + + T Q Y A I+ + RD +K RE RI
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE------REARIC 65
Query: 497 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNAL 556
+ L HP IV+L+D S + + V + G +L + + SE +A I QI+ ++
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYL-VFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124
Query: 557 KYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA 616
+ + I+H DLKP N+LL + + +K+ DFGL+ + D + A
Sbjct: 125 NHCH--LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGD-------QQAWFGFA 175
Query: 617 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILK 676
GT YL PE V+ K+P VD+W+ GVI Y L G PF ++ Q + Q+ +K
Sbjct: 176 GTPGYLSPE--VLRKDP--YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQ---IK 227
Query: 677 ATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
A FP VTPEAK I + L RI + P++
Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,513,696
Number of Sequences: 37866
Number of extensions: 1472874
Number of successful extensions: 9508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 866
Number of HSP's that attempted gapping in prelim test: 6722
Number of HSP's gapped (non-prelim): 2162
length of query: 750
length of database: 18,247,518
effective HSP length: 110
effective length of query: 640
effective length of database: 14,082,258
effective search space: 9012645120
effective search space used: 9012645120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.