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Search of human proteins with 13186236
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13186236 fibroblast growth factor receptor 1 isoform 4
precursor [Homo sapiens]
(731 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1502 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1497 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1436 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1431 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 1331 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1125 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1117 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1109 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1078 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1068 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1016 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1002 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 986 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 926 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 868 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 868 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 841 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 788 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 709 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 634 0.0
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 471 e-132
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 466 e-131
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 334 2e-91
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 328 1e-89
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 328 1e-89
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 321 2e-87
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 269 6e-72
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 268 2e-71
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 250 4e-66
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 3e-64
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1502 bits (3888), Expect = 0.0
Identities = 731/731 (100%), Positives = 731/731 (100%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
Query: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
Query: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV
Sbjct: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
Query: 301 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 360
GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS
Sbjct: 301 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 360
Query: 361 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 420
SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV
Sbjct: 361 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 420
Query: 421 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 480
AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE
Sbjct: 421 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 480
Query: 481 YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV 540
YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV
Sbjct: 481 YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV 540
Query: 541 TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW 600
TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW
Sbjct: 541 TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW 600
Query: 601 EIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 660
EIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV
Sbjct: 601 EIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 660
Query: 661 EDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHP 720
EDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHP
Sbjct: 661 EDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHP 720
Query: 721 AQLANGGLKRR 731
AQLANGGLKRR
Sbjct: 721 AQLANGGLKRR 731
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1497 bits (3875), Expect = 0.0
Identities = 731/733 (99%), Positives = 731/733 (99%), Gaps = 2/733 (0%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN-- 58
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 59 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 118
PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 119 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 178
YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 179 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 238
GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
Query: 239 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 298
NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC
Sbjct: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
Query: 299 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 358
MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL
Sbjct: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 360
Query: 359 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 418
SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT
Sbjct: 361 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 420
Query: 419 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 478
KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 421 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 480
Query: 479 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 538
REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV
Sbjct: 481 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 540
Query: 539 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 598
LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL
Sbjct: 541 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 600
Query: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658
LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 601 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 660
Query: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 718
LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR
Sbjct: 661 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 720
Query: 719 HPAQLANGGLKRR 731
HPAQLANGGLKRR
Sbjct: 721 HPAQLANGGLKRR 733
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1436 bits (3717), Expect = 0.0
Identities = 701/701 (100%), Positives = 701/701 (100%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS
Sbjct: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 179
Query: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH
Sbjct: 180 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 239
Query: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG
Sbjct: 240 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 299
Query: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270
PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA
Sbjct: 300 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 359
Query: 271 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 330
LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI
Sbjct: 360 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 419
Query: 331 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 390
PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG
Sbjct: 420 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 479
Query: 391 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 450
KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH
Sbjct: 480 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 539
Query: 451 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 510
KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV
Sbjct: 540 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 599
Query: 511 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 570
SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR
Sbjct: 600 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 659
Query: 571 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 630
LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK
Sbjct: 660 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 719
Query: 631 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 690
PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP
Sbjct: 720 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 779
Query: 691 DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 731
DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 780 DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
Score = 101 bits (252), Expect = 2e-21
Identities = 82/303 (27%), Positives = 118/303 (38%), Gaps = 78/303 (25%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH------------------ 162
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
Query: 163 ----RPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
P+ K V V+F C P P ++WLK NG + PD
Sbjct: 143 NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFKPD 198
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 199 H-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP 250
Query: 273 ERP 275
RP
Sbjct: 251 HRP 253
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1431 bits (3704), Expect = 0.0
Identities = 701/703 (99%), Positives = 701/703 (99%), Gaps = 2/703 (0%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 88
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
Query: 89 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 148
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
Query: 149 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 208
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
Query: 209 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 268
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
Query: 269 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 328
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 419
Query: 329 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 388
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
Query: 389 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 448
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
Query: 449 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 508
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 509 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 568
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
Query: 569 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 628
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM
Sbjct: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 719
Query: 629 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 688
DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 720 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 779
Query: 689 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 731
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 780 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 822
Score = 100 bits (250), Expect = 4e-21
Identities = 82/305 (26%), Positives = 118/305 (38%), Gaps = 80/305 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP------------------- 161
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
Query: 162 -----HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
P+ K V V+F C P P ++WLK NG +
Sbjct: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 198
Query: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270
PD+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 199 PDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER 250
Query: 271 LEERP 275
RP
Sbjct: 251 SPHRP 255
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 1331 bits (3444), Expect = 0.0
Identities = 664/703 (94%), Positives = 664/703 (94%), Gaps = 39/703 (5%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 88
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
Query: 89 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 148
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
Query: 149 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 208
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
Query: 209 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 268
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
Query: 269 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 328
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 419
Query: 329 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 388
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
Query: 389 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 448
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
Query: 449 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 508
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 509 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 568
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
Query: 569 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 628
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
Query: 629 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 688
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
Query: 689 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 731
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 743 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
Score = 100 bits (250), Expect = 4e-21
Identities = 82/305 (26%), Positives = 118/305 (38%), Gaps = 80/305 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP------------------- 161
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
Query: 162 -----HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
P+ K V V+F C P P ++WLK NG +
Sbjct: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 198
Query: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270
PD+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 199 PDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER 250
Query: 271 LEERP 275
RP
Sbjct: 251 SPHRP 255
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1125 bits (2910), Expect = 0.0
Identities = 544/701 (77%), Positives = 613/701 (87%), Gaps = 8/701 (1%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP+
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINH
Sbjct: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 242
Query: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
TY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK G
Sbjct: 243 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 302
Query: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270
PD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A
Sbjct: 303 PDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA 362
Query: 271 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 330
+ SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K I
Sbjct: 363 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 422
Query: 331 PLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLV 388
PLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L
Sbjct: 423 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 482
Query: 389 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 448
LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIG
Sbjct: 483 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 542
Query: 449 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 508
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KD
Sbjct: 543 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 602
Query: 509 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 568
LVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTN
Sbjct: 603 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 662
Query: 569 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 628
GRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRM
Sbjct: 663 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 722
Query: 629 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 688
DKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS
Sbjct: 723 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 782
Query: 689 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729
+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 783 YPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 820
Score = 51.6 bits (122), Expect = 3e-06
Identities = 63/303 (20%), Positives = 106/303 (34%), Gaps = 75/303 (24%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDA--AVISWTKDGVHLGPNNRTVLIGEY-- 91
Query: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
+ + P D G Y C S + ++V +
Sbjct: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
Query: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKE---- 197
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
+ Q + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 198 ---FKQEHRIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSP 253
Query: 273 ERP 275
RP
Sbjct: 254 HRP 256
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1117 bits (2890), Expect = 0.0
Identities = 549/731 (75%), Positives = 617/731 (84%), Gaps = 28/731 (3%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E D T
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVE-----------------------DTTLEPEG 37
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
Query: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
Query: 301 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 359
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLS
Sbjct: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
Query: 360 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 418
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 338 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 397
Query: 419 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 478
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 398 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 457
Query: 479 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 538
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 458 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 517
Query: 539 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 598
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 518 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 577
Query: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658
+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 578 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 637
Query: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 718
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 638 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 696
Query: 719 HPAQLANGGLK 729
+P NG +K
Sbjct: 697 YPH--INGSVK 705
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1109 bits (2868), Expect = 0.0
Identities = 547/731 (74%), Positives = 615/731 (84%), Gaps = 30/731 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E D T
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVE-----------------------DTTLEPEG 37
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
Query: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
Query: 301 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 359
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +RLS
Sbjct: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLS 335
Query: 360 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 418
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 336 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 395
Query: 419 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 478
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 396 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 455
Query: 479 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 538
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 456 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 515
Query: 539 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 598
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 516 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 575
Query: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658
+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 576 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 635
Query: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 718
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 636 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 694
Query: 719 HPAQLANGGLK 729
+P NG +K
Sbjct: 695 YPH--INGSVK 703
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1078 bits (2789), Expect = 0.0
Identities = 528/704 (75%), Positives = 601/704 (85%), Gaps = 13/704 (1%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP+
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINH
Sbjct: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 242
Query: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
TY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK G
Sbjct: 243 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 302
Query: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL-- 268
PD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAWLTVL
Sbjct: 303 PDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
Query: 269 -EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLA 327
+A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL
Sbjct: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
Query: 328 KSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRD 385
K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD
Sbjct: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
Query: 386 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMK 445
+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMK
Sbjct: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
Query: 446 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 505
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++
Sbjct: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
Query: 506 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKK 565
KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKK
Sbjct: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
Query: 566 TTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG 625
TTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEG
Sbjct: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
Query: 626 HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQY 685
HRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QY
Sbjct: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQY 780
Query: 686 SPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729
SPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 781 SPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 821
Score = 51.6 bits (122), Expect = 3e-06
Identities = 63/303 (20%), Positives = 106/303 (34%), Gaps = 75/303 (24%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDA--AVISWTKDGVHLGPNNRTVLIGEY-- 91
Query: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
+ + P D G Y C S + ++V +
Sbjct: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
Query: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKE---- 197
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
+ Q + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 198 ---FKQEHRIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSP 253
Query: 273 ERP 275
RP
Sbjct: 254 HRP 256
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1068 bits (2761), Expect = 0.0
Identities = 522/695 (75%), Positives = 589/695 (84%), Gaps = 11/695 (1%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 114
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGG
Sbjct: 61 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 117
Query: 115 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 174
YKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA 177
Query: 175 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV 234
+ +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EV
Sbjct: 178 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEV 237
Query: 235 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAF 294
L++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G F
Sbjct: 238 LYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVF 297
Query: 295 LISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR 354
LI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR
Sbjct: 298 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 357
Query: 355 -PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 412
+RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKD
Sbjct: 358 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 417
Query: 413 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 472
KP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 418 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 477
Query: 473 ASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD 532
ASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRD
Sbjct: 478 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 537
Query: 533 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 592
LAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDV
Sbjct: 538 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 597
Query: 593 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 652
WSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQ
Sbjct: 598 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 657
Query: 653 RPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 687
RPTFKQLVEDLDRI+ LT+N+E +S +D + P
Sbjct: 658 RPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1016 bits (2626), Expect = 0.0
Identities = 502/684 (73%), Positives = 570/684 (83%), Gaps = 16/684 (2%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 114
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGG
Sbjct: 61 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 117
Query: 115 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 174
YKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA 177
Query: 175 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV 234
+ +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E V
Sbjct: 178 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--V 235
Query: 235 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCT 291
L L NV+ DAGEY C N IG ++ SAWLTVL +A + SP YLEI IYC
Sbjct: 236 LALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCI 295
Query: 292 GAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 351
G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS
Sbjct: 296 GVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTP 355
Query: 352 LVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGL 409
LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+
Sbjct: 356 LVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGI 415
Query: 410 DKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVI 469
DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVI
Sbjct: 416 DKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVI 475
Query: 470 VEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCI 529
VEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCI
Sbjct: 476 VEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCI 535
Query: 530 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ 589
HRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQ
Sbjct: 536 HRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQ 595
Query: 590 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV 649
SDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAV
Sbjct: 596 SDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV 655
Query: 650 PSQRPTFKQLVEDLDRIVALTSNQ 673
PSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 656 PSQRPTFKQLVEDLDRILTLTTNE 679
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1002 bits (2590), Expect = 0.0
Identities = 489/648 (75%), Positives = 554/648 (85%), Gaps = 10/648 (1%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP+
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
Query: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINH
Sbjct: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 242
Query: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
TY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK G
Sbjct: 243 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 302
Query: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL-- 268
PD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAWLTVL
Sbjct: 303 PDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
Query: 269 -EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLA 327
+A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL
Sbjct: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
Query: 328 KSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRD 385
K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD
Sbjct: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
Query: 386 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMK 445
+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMK
Sbjct: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
Query: 446 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 505
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++
Sbjct: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
Query: 506 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKK 565
KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKK
Sbjct: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
Query: 566 TTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG 625
TTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEG
Sbjct: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
Query: 626 HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 673
HRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
Score = 51.6 bits (122), Expect = 3e-06
Identities = 63/303 (20%), Positives = 106/303 (34%), Gaps = 75/303 (24%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDA--AVISWTKDGVHLGPNNRTVLIGEY-- 91
Query: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
+ + P D G Y C S + ++V +
Sbjct: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
Query: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKE---- 197
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
+ Q + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 198 ---FKQEHRIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSP 253
Query: 273 ERP 275
RP
Sbjct: 254 HRP 256
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 986 bits (2549), Expect = 0.0
Identities = 483/682 (70%), Positives = 566/682 (82%), Gaps = 13/682 (1%)
Query: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 214 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 273
PYV +LKTAG NTTDKE+EVL L NV+FEDAGEYTCLAGNSIG SHHSAWL VL A EE
Sbjct: 303 TPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEE 362
Query: 274 R-PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPL 332
A +Y I+ Y G FL +V +V + +++S KK VHK+++ PL
Sbjct: 363 LVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPL 419
Query: 333 RRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKP 392
+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL LGKP
Sbjct: 420 KRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP 477
Query: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
LGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKN
Sbjct: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
Query: 453 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 512
IINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSC
Sbjct: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
Query: 513 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 572
AYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLP
Sbjct: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
Query: 573 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 632
VKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+
Sbjct: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
Query: 633 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDT 692
NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP DT
Sbjct: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 777
Query: 693 RSSTCSSGEDSVFSHEPLPEEP 714
SS+ SSG+DSVF+H+ LP P
Sbjct: 778 PSSS-SSGDDSVFAHDLLPPAP 798
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 926 bits (2392), Expect = 0.0
Identities = 460/685 (67%), Positives = 550/685 (80%), Gaps = 17/685 (2%)
Query: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 214 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL--EAL 271
PYV +LK+ + + ++ L L NVS D GEY C A N IG++ + WL+V A
Sbjct: 303 TPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAA 361
Query: 272 EER--PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 329
EE A +Y I+ Y G FL +V +V + +++S KK VHK+++
Sbjct: 362 EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKISR- 418
Query: 330 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 389
PL+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL L
Sbjct: 419 FPLKRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTL 476
Query: 390 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 449
GKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGK
Sbjct: 477 GKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGK 536
Query: 450 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 509
HKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDL
Sbjct: 537 HKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDL 596
Query: 510 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 569
VSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNG
Sbjct: 597 VSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNG 656
Query: 570 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 629
RLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMD
Sbjct: 657 RLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 716
Query: 630 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 689
KP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP
Sbjct: 717 KPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGG 776
Query: 690 PDTRSSTCSSGEDSVFSHEPLPEEP 714
DT SS+ SSG+DSVF+H+ LP P
Sbjct: 777 QDTPSSS-SSGDDSVFAHDLLPPAP 800
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 868 bits (2242), Expect = 0.0
Identities = 445/705 (63%), Positives = 541/705 (76%), Gaps = 27/705 (3%)
Query: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
Query: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
Query: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
Query: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCL 251
QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCL
Sbjct: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCL 334
Query: 252 AGNSIGLSHHSAWLTVLEALEERP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKM 308
AGNSIGLS+ SAWLTVL EE P A Y +II+Y +G+ ++ ++ +Y+
Sbjct: 335 AGNSIGLSYQSAWLTVLP--EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR- 391
Query: 309 KSGTKKSDFHSQ--MAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPML 366
G H + V KL++ PL RQ ++ + SS +S LVR RLSSSG +L
Sbjct: 392 --GQALHGRHPRPPATVQKLSR-FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALL 446
Query: 367 AGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 426
AG+ +LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK
Sbjct: 447 AGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK 506
Query: 427 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 486
+A++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARR
Sbjct: 507 DNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR 566
Query: 487 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 546
PPG + + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVM
Sbjct: 567 PPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVM 626
Query: 547 KIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG 606
KIADFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLG
Sbjct: 627 KIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLG 686
Query: 607 GSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 666
GSPYPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++
Sbjct: 687 GSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 746
Query: 667 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 711
+ L ++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 747 L-LAVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 788
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 868 bits (2242), Expect = 0.0
Identities = 445/705 (63%), Positives = 541/705 (76%), Gaps = 27/705 (3%)
Query: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
Query: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
Query: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
Query: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCL 251
QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCL
Sbjct: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCL 334
Query: 252 AGNSIGLSHHSAWLTVLEALEERP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKM 308
AGNSIGLS+ SAWLTVL EE P A Y +II+Y +G+ ++ ++ +Y+
Sbjct: 335 AGNSIGLSYQSAWLTVLP--EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR- 391
Query: 309 KSGTKKSDFHSQ--MAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPML 366
G H + V KL++ PL RQ ++ + SS +S LVR RLSSSG +L
Sbjct: 392 --GQALHGRHPRPPATVQKLSR-FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALL 446
Query: 367 AGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 426
AG+ +LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK
Sbjct: 447 AGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK 506
Query: 427 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 486
+A++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARR
Sbjct: 507 DNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR 566
Query: 487 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 546
PPG + + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVM
Sbjct: 567 PPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVM 626
Query: 547 KIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG 606
KIADFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLG
Sbjct: 627 KIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLG 686
Query: 607 GSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 666
GSPYPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++
Sbjct: 687 GSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 746
Query: 667 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 711
+ L ++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 747 L-LAVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 788
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 841 bits (2173), Expect = 0.0
Identities = 432/700 (61%), Positives = 516/700 (73%), Gaps = 57/700 (8%)
Query: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME 71
LC AR S TL D+L SS +DD+D S + ++ P APYWT P++ME
Sbjct: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRME 156
Query: 72 KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP 131
KKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVP
Sbjct: 157 KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVP 216
Query: 132 SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 191
SD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD
Sbjct: 217 SDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD 276
Query: 192 PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCL 251
QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCL
Sbjct: 277 AQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCL 334
Query: 252 AGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSG 311
AGNSIGLS+ SAWLTVL P + L +G
Sbjct: 335 AGNSIGLSYQSAWLTVLPGTGRIPHLTCDSL-------------------------TPAG 369
Query: 312 TKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE 371
KS + S +S +S S LVR RLSSSG +LAG+
Sbjct: 370 RTKSP------------------TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVS 411
Query: 372 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE 431
+LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++
Sbjct: 412 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 471
Query: 432 KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 491
KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG +
Sbjct: 472 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPD 531
Query: 492 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 551
+ + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADF
Sbjct: 532 LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADF 591
Query: 552 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 611
GLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYP
Sbjct: 592 GLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP 651
Query: 612 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 671
G+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L
Sbjct: 652 GIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAV 710
Query: 672 NQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 711
++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 711 SEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 748
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 66 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 125
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
Query: 126 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 174
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
Query: 175 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
Query: 222 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 275
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 788 bits (2036), Expect = 0.0
Identities = 428/759 (56%), Positives = 515/759 (67%), Gaps = 81/759 (10%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY-- 91
Query: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
+ + P D G Y C S + ++V +
Sbjct: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
Query: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
R+P+ + V + V+F C +P P ++WLK NG + +
Sbjct: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQE 201
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
+ + G ++ ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 202 H-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGR 253
Query: 273 ERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPL 332
E+ + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPL
Sbjct: 254 EKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 312
Query: 333 RRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLG 390
RRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LG
Sbjct: 313 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 372
Query: 391 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 450
KPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKH
Sbjct: 373 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 432
Query: 451 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 510
KNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLV
Sbjct: 433 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 492
Query: 511 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 570
SC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGR
Sbjct: 493 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 552
Query: 571 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 630
LPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDK
Sbjct: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612
Query: 631 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 690
P+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+P
Sbjct: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYP 672
Query: 691 DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729
DTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 673 DTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 708
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 709 bits (1830), Expect = 0.0
Identities = 399/766 (52%), Positives = 488/766 (63%), Gaps = 99/766 (12%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY-- 91
Query: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
+ + P D G Y C S + ++V +
Sbjct: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
Query: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
R+P+ + V + V+F C +P P ++WLK NG + +
Sbjct: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQE 201
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
+ + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 202 H-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSP 253
Query: 273 ERPAVMTSPLYLEIIIYCTGAFLISCMVGSV-------IVYKMKSGTKKSDFHSQMAVHK 325
RP ++ + L G C V S I + K+G+K
Sbjct: 254 HRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP--------- 303
Query: 326 LAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELP 383
+P + + VSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE P
Sbjct: 304 --DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 361
Query: 384 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 443
RD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEM
Sbjct: 362 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 421
Query: 444 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 503
MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ
Sbjct: 422 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 481
Query: 504 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 563
++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYY
Sbjct: 482 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 541
Query: 564 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 623
KKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLK
Sbjct: 542 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 601
Query: 624 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLD 683
EGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+
Sbjct: 602 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 661
Query: 684 QYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729
QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 662 QYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 704
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 634 bits (1636), Expect = 0.0
Identities = 333/547 (60%), Positives = 395/547 (72%), Gaps = 34/547 (6%)
Query: 176 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVL 235
V + V F C +P P I WLK NG + ++ + G+ ++ ++
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWSLV 214
Query: 236 HLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP-------AVMTSPLYLEIII 288
+ +V D G YTC+ N G + L VLE RP A T+ L ++
Sbjct: 215 -MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF 273
Query: 289 YCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMN 347
+C VY + H ++ K+ P + VS +S+ASM+
Sbjct: 274 HCK-------------VYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMS 320
Query: 348 SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 407
S LVR +RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAI
Sbjct: 321 SNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 380
Query: 408 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 467
G+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 381 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 440
Query: 468 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 527
V+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+K
Sbjct: 441 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 500
Query: 528 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 587
CIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YT
Sbjct: 501 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 560
Query: 588 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 647
HQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWH
Sbjct: 561 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 620
Query: 648 AVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH 707
A PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H
Sbjct: 621 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAH 679
Query: 708 EPLPEEP 714
+ LP P
Sbjct: 680 DLLPPAP 686
Score = 277 bits (709), Expect = 2e-74
Identities = 124/190 (65%), Positives = 156/190 (82%), Gaps = 6/190 (3%)
Query: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 214 LPYVQILKTA 223
PYV +LK +
Sbjct: 303 TPYVTVLKVS 312
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 471 bits (1211), Expect = e-132
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
Query: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 170 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 229
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 77 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 119
Query: 230 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 275
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 120 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 164
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 466 bits (1198), Expect = e-131
Identities = 221/223 (99%), Positives = 221/223 (99%), Gaps = 2/223 (0%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN-- 58
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 59 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 118
PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 119 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 178
YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 179 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 170 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 229
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 79 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 121
Query: 230 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 275
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 122 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 166
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 334 bits (857), Expect = 2e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 133 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 190
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 191 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 250
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
Query: 251 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 310
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
Query: 311 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 368
TV + + +G L ++ P L
Sbjct: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
Query: 369 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 425
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
Query: 426 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 483
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
Query: 484 ------------ARRPPGLEYC---------------------------------YNPSH 498
AR G +Y
Sbjct: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
Query: 499 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 554
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
Query: 555 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 614
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
Query: 615 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 673
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
Query: 674 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 718
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 8/143 (5%)
Query: 62 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 121
P+ ME + A + V+ G P P ++W KNG + +H I V
Sbjct: 328 PFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHV---- 382
Query: 122 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 181
+ + V D GNYT I+ N ++ + +V P + ++ + + G+
Sbjct: 383 --LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTT 440
Query: 182 VEFMCKVYSDPQP-HIQWLKHIE 203
C VY+ P P HI W +E
Sbjct: 441 QTLTCTVYAIPPPHHIHWYWQLE 463
Score = 37.4 bits (85), Expect = 0.050
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 123 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 180
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
V K P P I+W K NG + N T K VL + V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
Query: 241 SFEDAGEYTCLAGNSIGLSHHS 262
S D G YT + N I S
Sbjct: 389 SERDTGNYTVILTNPISKEKQS 410
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 81 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Query: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSA--WLTVLE 269
NL + L + + ++ ++ L+N S +D G+Y CLA + H LTVLE
Sbjct: 605 NLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 328 bits (840), Expect = 1e-89
Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)
Query: 293 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 351
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 352 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 411
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 412 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 471
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 472 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 523
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 524 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 583
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 584 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 643
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 644 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 679
CW P +RP F + +DL+++ + ++YLDL+
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 328 bits (840), Expect = 1e-89
Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)
Query: 293 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 351
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 352 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 411
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 412 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 471
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 472 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 523
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 524 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 583
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 584 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 643
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 644 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 679
CW P +RP F + +DL+++ + ++YLDL+
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 321 bits (822), Expect = 2e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
Query: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
Query: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
Query: 301 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 358
++ + KMK + K+D+ +++ +PL Q
Sbjct: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
Query: 359 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 417
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
Query: 418 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 476
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
Query: 477 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 500
NL YL+++R PGLE P +
Sbjct: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
Query: 501 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 545
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
Query: 546 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 605
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
Query: 606 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 664
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
Query: 665 RIVALTSNQEYLD 677
++ Q+ D
Sbjct: 1156 DLLQANVQQDGKD 1168
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 65 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 122
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
Query: 123 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 178
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
Query: 179 GSNVEFMCKVYSDPQPHIQWLKH 201
GS C Y PQP I+W H
Sbjct: 447 GSRQILTCTAYGIPQPTIKWFWH 469
Score = 40.8 bits (94), Expect = 0.005
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 75 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 134
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
Query: 135 GNYTCIVENEYGSINHTYQLDV 156
G Y C N+ GS+ + L V
Sbjct: 727 GVYHCKATNQKGSVESSAYLTV 748
Score = 35.0 bits (79), Expect = 0.25
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 124 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 177
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
Query: 178 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 237
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
Query: 238 RNVSFEDAGEYTCL 251
++V+ EDAG YT L
Sbjct: 393 KDVTEEDAGNYTIL 406
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 269 bits (688), Expect = 6e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 123 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 180
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 181 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 239
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
Query: 240 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 299
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
Query: 300 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 351
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
Query: 352 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 381
+ P L TP+L G + Y+ + P +E
Sbjct: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
Query: 382 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 412
LP D RL GK LG G FG+VV A A GL K
Sbjct: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
Query: 413 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 472
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
Query: 473 ASKGNLREYLQARR--------------------------------------PPGLEYC- 493
G+L +L+ +R PG+ Y
Sbjct: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
Query: 494 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 532
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
Query: 533 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 592
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
Query: 593 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 651
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
Query: 652 QRPTFKQLVEDLDRIVALTSNQEYLDLS 679
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 373 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 432
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
Query: 433 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 470
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 471 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 497
E + + EY+ + PG+ Y
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
Query: 498 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 550
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
Query: 551 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 610
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
Query: 611 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 669
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
Query: 670 TSNQEYLDLS 679
++N Y +L+
Sbjct: 931 STNHIYSNLA 940
Score = 37.0 bits (84), Expect = 0.065
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 123 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 180
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 181 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 239
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
Query: 240 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 293
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 250 bits (638), Expect = 4e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
Query: 453 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 512
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
Query: 513 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 572
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
Query: 573 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 632
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
Query: 633 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 680
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (622), Expect = 3e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 453 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 512
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 513 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 572
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
Query: 573 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 632
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 633 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 667
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,329,737
Number of Sequences: 37866
Number of extensions: 1578775
Number of successful extensions: 14214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 410
Number of HSP's that attempted gapping in prelim test: 7813
Number of HSP's gapped (non-prelim): 3346
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.