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Search of human proteins with 13186234
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13186234 fibroblast growth factor receptor 1 isoform 3
precursor [Homo sapiens]
(733 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1506 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1497 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1440 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1431 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 1340 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1124 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1115 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1107 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1078 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1067 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1015 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1001 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 982 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 922 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 868 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 868 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 841 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 788 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 709 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 635 0.0
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 474 e-134
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 466 e-131
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 334 2e-91
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 328 1e-89
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 328 1e-89
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 321 2e-87
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 269 6e-72
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 268 2e-71
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 250 4e-66
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 3e-64
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1506 bits (3898), Expect = 0.0
Identities = 733/733 (100%), Positives = 733/733 (100%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
Query: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC
Sbjct: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
Query: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 360
MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL
Sbjct: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 360
Query: 361 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 420
SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT
Sbjct: 361 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 420
Query: 421 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 480
KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 421 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 480
Query: 481 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 540
REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV
Sbjct: 481 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 540
Query: 541 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 600
LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL
Sbjct: 541 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 600
Query: 601 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 660
LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 601 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 660
Query: 661 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 720
LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR
Sbjct: 661 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 720
Query: 721 HPAQLANGGLKRR 733
HPAQLANGGLKRR
Sbjct: 721 HPAQLANGGLKRR 733
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1497 bits (3875), Expect = 0.0
Identities = 731/733 (99%), Positives = 731/733 (99%), Gaps = 2/733 (0%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN-- 58
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR
Sbjct: 59 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 118
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL
Sbjct: 119 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 178
Query: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR
Sbjct: 179 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 238
Query: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC
Sbjct: 239 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 298
Query: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 360
MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL
Sbjct: 299 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 358
Query: 361 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 420
SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT
Sbjct: 359 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 418
Query: 421 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 480
KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 419 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 478
Query: 481 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 540
REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV
Sbjct: 479 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 538
Query: 541 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 600
LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL
Sbjct: 539 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 598
Query: 601 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 660
LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658
Query: 661 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 720
LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR
Sbjct: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 718
Query: 721 HPAQLANGGLKRR 733
HPAQLANGGLKRR
Sbjct: 719 HPAQLANGGLKRR 731
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1440 bits (3727), Expect = 0.0
Identities = 703/703 (100%), Positives = 703/703 (100%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
Query: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
Query: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
Query: 271 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 330
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 419
Query: 331 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 390
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
Query: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 450
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
Query: 451 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 570
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
Query: 571 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 630
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM
Sbjct: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 719
Query: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 690
DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 720 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 779
Query: 691 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 733
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 780 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 822
Score = 100 bits (248), Expect = 6e-21
Identities = 82/307 (26%), Positives = 118/307 (38%), Gaps = 82/307 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP----------------- 163
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
Query: 164 -------HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
P+ K V V+F C P P ++WLK NG +
Sbjct: 141 TDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKE 196
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
PD+ + G ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 197 FKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
Query: 271 EALEERP 277
E RP
Sbjct: 249 ERSPHRP 255
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1431 bits (3704), Expect = 0.0
Identities = 701/703 (99%), Positives = 701/703 (99%), Gaps = 2/703 (0%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 120 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 177
Query: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 178 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 237
Query: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 238 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 297
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 298 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 357
Query: 271 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 330
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 358 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 417
Query: 331 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 390
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 418 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 477
Query: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 450
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 478 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 537
Query: 451 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 538 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 597
Query: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 570
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 598 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 657
Query: 571 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 630
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM
Sbjct: 658 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 717
Query: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 690
DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 718 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 777
Query: 691 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 733
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 778 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
Score = 100 bits (250), Expect = 4e-21
Identities = 82/305 (26%), Positives = 118/305 (38%), Gaps = 80/305 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH---------------- 164
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
Query: 165 ------RPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 212
P+ K V V+F C P P ++WLK NG +
Sbjct: 141 TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 196
Query: 213 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 272
PD+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 197 PDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER 248
Query: 273 LEERP 277
RP
Sbjct: 249 SPHRP 253
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 1340 bits (3467), Expect = 0.0
Identities = 666/703 (94%), Positives = 666/703 (94%), Gaps = 37/703 (5%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
Query: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
Query: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
Query: 271 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 330
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 419
Query: 331 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 390
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
Query: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 450
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
Query: 451 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 570
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
Query: 571 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 630
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
Query: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 690
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
Query: 691 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 733
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 743 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
Score = 100 bits (248), Expect = 6e-21
Identities = 82/307 (26%), Positives = 118/307 (38%), Gaps = 82/307 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP----------------- 163
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
Query: 164 -------HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
P+ K V V+F C P P ++WLK NG +
Sbjct: 141 TDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKE 196
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
PD+ + G ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 197 FKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
Query: 271 EALEERP 277
E RP
Sbjct: 249 ERSPHRP 255
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1124 bits (2908), Expect = 0.0
Identities = 544/703 (77%), Positives = 613/703 (87%), Gaps = 10/703 (1%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
NHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL
Sbjct: 301 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 360
Query: 271 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 330
A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K
Sbjct: 361 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK 420
Query: 331 SIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDR 388
IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+
Sbjct: 421 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK 480
Query: 389 LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM 448
L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKM
Sbjct: 481 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 540
Query: 449 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS 508
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++
Sbjct: 541 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF 600
Query: 509 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT 568
KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKT
Sbjct: 601 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT 660
Query: 569 TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH 628
TNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGH
Sbjct: 661 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 720
Query: 629 RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYS 688
RMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYS
Sbjct: 721 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS 780
Query: 689 PSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731
PS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 781 PSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 820
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1115 bits (2885), Expect = 0.0
Identities = 548/733 (74%), Positives = 616/733 (84%), Gaps = 30/733 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
M SW + V+ ATL ARPS +L E L
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEG----------------------- 37
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 38 --APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVR 95
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +
Sbjct: 96 NQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV 155
Query: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++R
Sbjct: 156 GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIR 215
Query: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
NV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+C
Sbjct: 216 NVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIAC 275
Query: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSR 359
MV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +R
Sbjct: 276 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTR 335
Query: 360 LSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 418
LSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 336 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 395
Query: 419 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 478
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG
Sbjct: 396 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 455
Query: 479 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 538
NLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAAR
Sbjct: 456 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 515
Query: 539 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 598
NVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFG
Sbjct: 516 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 575
Query: 599 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 658
VL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTF
Sbjct: 576 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 635
Query: 659 KQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCL 718
KQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCL
Sbjct: 636 KQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCL 694
Query: 719 PRHPAQLANGGLK 731
P++P NG +K
Sbjct: 695 PQYPH--INGSVK 705
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1107 bits (2863), Expect = 0.0
Identities = 546/733 (74%), Positives = 614/733 (83%), Gaps = 32/733 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
M SW + V+ ATL ARPS +L E L
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEG----------------------- 37
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 38 --APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVR 95
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +
Sbjct: 96 NQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV 155
Query: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++R
Sbjct: 156 GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIR 215
Query: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
NV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+C
Sbjct: 216 NVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIAC 275
Query: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSR 359
MV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +R
Sbjct: 276 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTR 333
Query: 360 LSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 418
LSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 334 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 393
Query: 419 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 478
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG
Sbjct: 394 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 453
Query: 479 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 538
NLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAAR
Sbjct: 454 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 513
Query: 539 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 598
NVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFG
Sbjct: 514 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 573
Query: 599 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 658
VL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTF
Sbjct: 574 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 633
Query: 659 KQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCL 718
KQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCL
Sbjct: 634 KQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCL 692
Query: 719 PRHPAQLANGGLK 731
P++P NG +K
Sbjct: 693 PQYPH--INGSVK 703
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1078 bits (2787), Expect = 0.0
Identities = 528/706 (74%), Positives = 601/706 (85%), Gaps = 15/706 (2%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
NHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAWLTVL
Sbjct: 301 YGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVL 358
Query: 271 ---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 327
+A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHK
Sbjct: 359 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 418
Query: 328 LAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELP 385
L K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE P
Sbjct: 419 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 478
Query: 386 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 445
RD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEM
Sbjct: 479 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 538
Query: 446 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 505
MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ
Sbjct: 539 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 598
Query: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565
++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYY
Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
Query: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 625
KKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLK
Sbjct: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718
Query: 626 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLD 685
EGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+
Sbjct: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 778
Query: 686 QYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731
QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 779 QYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 821
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1067 bits (2759), Expect = 0.0
Identities = 522/697 (74%), Positives = 589/697 (84%), Gaps = 13/697 (1%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 55 TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 114
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 61 NKR-----APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 115
Query: 115 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 174
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 116 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 175
Query: 175 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 234
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+
Sbjct: 176 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEI 235
Query: 235 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 294
EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G
Sbjct: 236 EVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIG 295
Query: 295 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 354
FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS L
Sbjct: 296 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 355
Query: 355 VR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLD 412
VR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+D
Sbjct: 356 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 415
Query: 413 KDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 472
KDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
Sbjct: 416 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 475
Query: 473 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 532
EYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIH
Sbjct: 476 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 535
Query: 533 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQS 592
RDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQS
Sbjct: 536 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 595
Query: 593 DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 652
DVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVP
Sbjct: 596 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 655
Query: 653 SQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 689
SQRPTFKQLVEDLDRI+ LT+N+E +S +D + P
Sbjct: 656 SQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1015 bits (2624), Expect = 0.0
Identities = 502/686 (73%), Positives = 570/686 (83%), Gaps = 18/686 (2%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 55 TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 114
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 61 NKR-----APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 115
Query: 115 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 174
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 116 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 175
Query: 175 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 234
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E
Sbjct: 176 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE- 234
Query: 235 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIY 291
VL L NV+ DAGEY C N IG ++ SAWLTVL +A + SP YLEI IY
Sbjct: 235 -VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIY 293
Query: 292 CTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSG 351
C G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS
Sbjct: 294 CIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSN 353
Query: 352 VLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 409
LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+
Sbjct: 354 TPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAV 413
Query: 410 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 469
G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLY
Sbjct: 414 GIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY 473
Query: 470 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 529
VIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+K
Sbjct: 474 VIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 533
Query: 530 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 589
CIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YT
Sbjct: 534 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 593
Query: 590 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 649
HQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWH
Sbjct: 594 HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH 653
Query: 650 AVPSQRPTFKQLVEDLDRIVALTSNQ 675
AVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 654 AVPSQRPTFKQLVEDLDRILTLTTNE 679
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1001 bits (2588), Expect = 0.0
Identities = 489/650 (75%), Positives = 554/650 (85%), Gaps = 12/650 (1%)
Query: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
NHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAWLTVL
Sbjct: 301 YGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVL 358
Query: 271 ---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 327
+A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHK
Sbjct: 359 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 418
Query: 328 LAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELP 385
L K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE P
Sbjct: 419 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 478
Query: 386 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 445
RD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEM
Sbjct: 479 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 538
Query: 446 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 505
MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ
Sbjct: 539 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 598
Query: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565
++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYY
Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
Query: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 625
KKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLK
Sbjct: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718
Query: 626 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 675
EGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 982 bits (2539), Expect = 0.0
Identities = 483/684 (70%), Positives = 565/684 (82%), Gaps = 15/684 (2%)
Query: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 214 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 273
D PYV +LKTAG NTTDKE+EVL L NV+FEDAGEYTCLAGNSIG SHHSAWL VL A
Sbjct: 301 DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE 360
Query: 274 EER-PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 332
EE A +Y I+ Y G FL +V +V + +++S KK VHK+++
Sbjct: 361 EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-F 417
Query: 333 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 392
PL+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL LG
Sbjct: 418 PLKRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLG 475
Query: 393 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 452
KPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKH
Sbjct: 476 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 535
Query: 453 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 512
KNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLV
Sbjct: 536 KNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLV 595
Query: 513 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 572
SCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGR
Sbjct: 596 SCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR 655
Query: 573 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 632
LPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDK
Sbjct: 656 LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 715
Query: 633 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 692
P+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP
Sbjct: 716 PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQ 775
Query: 693 DTRSSTCSSGEDSVFSHEPLPEEP 716
DT SS+ SSG+DSVF+H+ LP P
Sbjct: 776 DTPSSS-SSGDDSVFAHDLLPPAP 798
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 922 bits (2382), Expect = 0.0
Identities = 460/687 (66%), Positives = 549/687 (79%), Gaps = 19/687 (2%)
Query: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 214 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL--E 271
D PYV +LK+ + + ++ L L NVS D GEY C A N IG++ + WL+V
Sbjct: 301 DGTPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPR 359
Query: 272 ALEER--PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLA 329
A EE A +Y I+ Y G FL +V +V + +++S KK VHK++
Sbjct: 360 AAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS 417
Query: 330 KSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRL 389
+ PL+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL
Sbjct: 418 R-FPLKRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARL 474
Query: 390 VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMI 449
LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMI
Sbjct: 475 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 534
Query: 450 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 509
GKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ K
Sbjct: 535 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 594
Query: 510 DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 569
DLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTT
Sbjct: 595 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 654
Query: 570 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 629
NGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHR
Sbjct: 655 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 714
Query: 630 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 689
MDKP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP
Sbjct: 715 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 774
Query: 690 SFPDTRSSTCSSGEDSVFSHEPLPEEP 716
DT SS+ SSG+DSVF+H+ LP P
Sbjct: 775 GGQDTPSSS-SSGDDSVFAHDLLPPAP 800
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 868 bits (2242), Expect = 0.0
Identities = 445/707 (62%), Positives = 542/707 (76%), Gaps = 29/707 (4%)
Query: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
Query: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
Query: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
Query: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT 251
SD QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYT
Sbjct: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYT 332
Query: 252 CLAGNSIGLSHHSAWLTVLEALEERP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVY 308
CLAGNSIGLS+ SAWLTVL EE P A Y +II+Y +G+ ++ ++ +Y
Sbjct: 333 CLAGNSIGLSYQSAWLTVLP--EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLY 390
Query: 309 KMKSGTKKSDFHSQ--MAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTP 366
+ G H + V KL++ PL RQ ++ + SS +S LVR RLSSSG
Sbjct: 391 R---GQALHGRHPRPPATVQKLSR-FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPA 444
Query: 367 MLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKM 426
+LAG+ +LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKM
Sbjct: 445 LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKM 504
Query: 427 LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 486
LK +A++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+A
Sbjct: 505 LKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRA 564
Query: 487 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 546
RRPPG + + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDN
Sbjct: 565 RRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN 624
Query: 547 VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 606
VMKIADFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFT
Sbjct: 625 VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT 684
Query: 607 LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 666
LGGSPYPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD
Sbjct: 685 LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
Query: 667 RIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 713
+++ L ++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 745 KVL-LAVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 788
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 868 bits (2242), Expect = 0.0
Identities = 445/707 (62%), Positives = 542/707 (76%), Gaps = 29/707 (4%)
Query: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
Query: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
Query: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
Query: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT 251
SD QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYT
Sbjct: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYT 332
Query: 252 CLAGNSIGLSHHSAWLTVLEALEERP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVY 308
CLAGNSIGLS+ SAWLTVL EE P A Y +II+Y +G+ ++ ++ +Y
Sbjct: 333 CLAGNSIGLSYQSAWLTVLP--EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLY 390
Query: 309 KMKSGTKKSDFHSQ--MAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTP 366
+ G H + V KL++ PL RQ ++ + SS +S LVR RLSSSG
Sbjct: 391 R---GQALHGRHPRPPATVQKLSR-FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPA 444
Query: 367 MLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKM 426
+LAG+ +LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKM
Sbjct: 445 LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKM 504
Query: 427 LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 486
LK +A++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+A
Sbjct: 505 LKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRA 564
Query: 487 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 546
RRPPG + + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDN
Sbjct: 565 RRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN 624
Query: 547 VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 606
VMKIADFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFT
Sbjct: 625 VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT 684
Query: 607 LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 666
LGGSPYPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD
Sbjct: 685 LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
Query: 667 RIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 713
+++ L ++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 745 KVL-LAVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 788
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 841 bits (2173), Expect = 0.0
Identities = 432/702 (61%), Positives = 517/702 (73%), Gaps = 59/702 (8%)
Query: 18 LCTARPSP------TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 71
LC AR S TL D+L SS +DD+D S + ++ P + APYWT P++
Sbjct: 100 LCLARGSMIVLQNLTLITGDSLTSS--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQR 154
Query: 72 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV 131
MEKKLHAVPA TVKF+CP++G P PT+RWLK+G+ F ++RIGG ++R+ WS++M+SV
Sbjct: 155 MEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESV 214
Query: 132 VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY 191
VPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVY
Sbjct: 215 VPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVY 274
Query: 192 SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT 251
SD QPHIQWLKHI +NGS G D PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYT
Sbjct: 275 SDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYT 332
Query: 252 CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMK 311
CLAGNSIGLS+ SAWLTVL P + L
Sbjct: 333 CLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSL-------------------------TP 367
Query: 312 SGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 371
+G KS + S +S +S S LVR RLSSSG +LAG+
Sbjct: 368 AGRTKSP------------------TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGL 409
Query: 372 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 431
+LP DP WE PRDRLVLGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A
Sbjct: 410 VSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA 469
Query: 432 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 491
++KDL+DL+SEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG
Sbjct: 470 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPG 529
Query: 492 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 551
+ + + E LS LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 530 PDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 589
Query: 552 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 611
DFGLAR +HHIDYYKKT+NGRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSP
Sbjct: 590 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP 649
Query: 612 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
YPG+PVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L
Sbjct: 650 YPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-L 708
Query: 672 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 713
++EYLDL + YSPS D SSTCSS DSVFSH+PLP
Sbjct: 709 AVSEEYLDLRLTFGPYSPSGGDA-SSTCSS-SDSVFSHDPLP 748
Score = 53.1 bits (126), Expect = 9e-07
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 68 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 127
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
Query: 128 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 176
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
Query: 177 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
Query: 224 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 277
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 788 bits (2035), Expect = 0.0
Identities = 428/761 (56%), Positives = 515/761 (67%), Gaps = 83/761 (10%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
M SW + V+ ATL ARPS +L E L +P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTL----------------------EPEEP 38
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY 117
P + PE ++ ++++ +C + W K+G P++R IG Y
Sbjct: 39 PTKYQISQPE-----VYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY 91
Query: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE----------------- 160
+ + P D G Y C S + ++V +
Sbjct: 92 --------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDF 143
Query: 161 --------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 212
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 144 VSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFK 199
Query: 213 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 272
++ + G ++ ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 200 QEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVAP 251
Query: 273 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 332
E+ + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K I
Sbjct: 252 GREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 310
Query: 333 PLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLV 390
PLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L
Sbjct: 311 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 370
Query: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 450
LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIG
Sbjct: 371 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 430
Query: 451 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KD
Sbjct: 431 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
Query: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 570
LVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTN
Sbjct: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 550
Query: 571 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 630
GRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRM
Sbjct: 551 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 610
Query: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 690
DKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS
Sbjct: 611 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670
Query: 691 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731
+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 671 YPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 708
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 709 bits (1829), Expect = 0.0
Identities = 399/768 (51%), Positives = 488/768 (63%), Gaps = 101/768 (13%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
M SW + V+ ATL ARPS +L E L +P
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTL----------------------EPEEP 38
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY 117
P + PE ++ ++++ +C + W K+G P++R IG Y
Sbjct: 39 PTKYQISQPE-----VYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY 91
Query: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE----------------- 160
+ + P D G Y C S + ++V +
Sbjct: 92 --------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDF 143
Query: 161 --------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 212
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 144 VSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFK 199
Query: 213 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 272
++ + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 200 QEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
Query: 273 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV-------IVYKMKSGTKKSDFHSQMAV 325
RP ++ + L G C V S I + K+G+K
Sbjct: 252 SPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP------- 303
Query: 326 HKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWE 383
+P + + VSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE
Sbjct: 304 ----DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 359
Query: 384 LPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEM 443
PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEM
Sbjct: 360 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 419
Query: 444 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE 503
EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PE
Sbjct: 420 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 479
Query: 504 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 563
EQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++ID
Sbjct: 480 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 539
Query: 564 YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKL 623
YYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKL
Sbjct: 540 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 599
Query: 624 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMP 683
LKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS P
Sbjct: 600 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 659
Query: 684 LDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731
L+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 660 LEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 704
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 635 bits (1639), Expect = 0.0
Identities = 364/705 (51%), Positives = 447/705 (63%), Gaps = 71/705 (10%)
Query: 45 SSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP--SSGTPNPTLRWL 102
+SSE T+ R P PE +++ + V+ CP G PT+ W+
Sbjct: 20 ASSESLGTEQRVVGRAAEVP---GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTV-WV 75
Query: 103 KNGKEFKPDHRI--GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV- 159
K+G P R+ G +++ S D G Y+C + H + + V
Sbjct: 76 KDGTGLVPSERVLVGPQRLQVLNAS-------HEDSGAYSCRQRLTQRVLCH-FSVRVTD 127
Query: 160 ----------ERSPHRPILQAGLPA--------NKTVAL--GSNVEFMCKVYSDPQPHIQ 199
E + G P K +A+ + V F C +P P I
Sbjct: 128 APSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS 187
Query: 200 WLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 259
WLK NG + ++ + G+ ++ ++ + +V D G YTC+ N G
Sbjct: 188 WLK----NGREFRGEH-------RIGGIKLRHQQWSLV-MESVVPSDRGNYTCVVENKFG 235
Query: 260 LSHHSAWLTVLEALEERP-------AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 312
+ L VLE RP A T+ L ++ +C VY
Sbjct: 236 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK-------------VYSDAQ 282
Query: 313 GTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 371
+ H ++ K+ P + VS +S+ASM+S LVR +RLSS P LA V
Sbjct: 283 PHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANV 342
Query: 372 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 431
SE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DA
Sbjct: 343 SELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 402
Query: 432 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 491
T+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPG
Sbjct: 403 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 462
Query: 492 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 551
L+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 463 LDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 522
Query: 552 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 611
DFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSP
Sbjct: 523 DFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 582
Query: 612 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
YPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +
Sbjct: 583 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV 642
Query: 672 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 716
TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 643 TSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 686
Score = 273 bits (699), Expect = 3e-73
Identities = 124/192 (64%), Positives = 155/192 (80%), Gaps = 8/192 (4%)
Query: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 214 DNLPYVQILKTA 225
D PYV +LK +
Sbjct: 301 DGTPYVTVLKVS 312
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 474 bits (1221), Expect = e-134
Identities = 223/223 (100%), Positives = 223/223 (100%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 172 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 231
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 79 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 121
Query: 232 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 277
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 122 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 166
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 466 bits (1198), Expect = e-131
Identities = 221/223 (99%), Positives = 221/223 (99%), Gaps = 2/223 (0%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPN-- 58
Query: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR
Sbjct: 59 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 118
Query: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL
Sbjct: 119 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 178
Query: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK
Sbjct: 179 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 172 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 231
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 77 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 119
Query: 232 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 277
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 120 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 164
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 334 bits (857), Expect = 2e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 135 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 192
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 193 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 252
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
Query: 253 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 312
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
Query: 313 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 370
TV + + +G L ++ P L
Sbjct: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
Query: 371 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 427
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
Query: 428 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 485
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
Query: 486 ------------ARRPPGLEYC---------------------------------YNPSH 500
AR G +Y
Sbjct: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
Query: 501 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 556
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
Query: 557 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 616
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
Query: 617 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 675
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
Query: 676 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 720
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/148 (24%), Positives = 60/148 (40%), Gaps = 8/148 (5%)
Query: 59 RMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYK 118
R+ P+ ME + A + V+ G P P ++W KNG + +H I
Sbjct: 323 RVHEKPFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGH 381
Query: 119 VRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTV 178
V + + V D GNYT I+ N ++ + +V P + ++ + +
Sbjct: 382 V------LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSY 435
Query: 179 ALGSNVEFMCKVYSDPQP-HIQWLKHIE 205
G+ C VY+ P P HI W +E
Sbjct: 436 QYGTTQTLTCTVYAIPPPHHIHWYWQLE 463
Score = 37.4 bits (85), Expect = 0.050
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 125 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 182
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 183 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 242
V K P P I+W K NG + N T K VL + V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
Query: 243 SFEDAGEYTCLAGNSIGLSHHS 264
S D G YT + N I S
Sbjct: 389 SERDTGNYTVILTNPISKEKQS 410
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 83 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Query: 215 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSA--WLTVLE 271
NL + L + + ++ ++ L+N S +D G+Y CLA + H LTVLE
Sbjct: 605 NLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 328 bits (840), Expect = 1e-89
Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)
Query: 295 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 353
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 354 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 413
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 414 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 473
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 474 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 525
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 526 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 585
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 586 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 645
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 646 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 681
CW P +RP F + +DL+++ + ++YLDL+
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 328 bits (840), Expect = 1e-89
Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)
Query: 295 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 353
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 354 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 413
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 414 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 473
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 474 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 525
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 526 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 585
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 586 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 645
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 646 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 681
CW P +RP F + +DL+++ + ++YLDL+
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 321 bits (822), Expect = 2e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 123 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 182
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
Query: 183 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 242
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
Query: 243 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 302
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
Query: 303 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 360
++ + KMK + K+D+ +++ +PL Q
Sbjct: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
Query: 361 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 419
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
Query: 420 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 478
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
Query: 479 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 502
NL YL+++R PGLE P +
Sbjct: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
Query: 503 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 547
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
Query: 548 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 607
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
Query: 608 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 666
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
Query: 667 RIVALTSNQEYLD 679
++ Q+ D
Sbjct: 1156 DLLQANVQQDGKD 1168
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 67 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 124
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
Query: 125 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
Query: 181 GSNVEFMCKVYSDPQPHIQWLKH 203
GS C Y PQP I+W H
Sbjct: 447 GSRQILTCTAYGIPQPTIKWFWH 469
Score = 40.8 bits (94), Expect = 0.005
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 77 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 136
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
Query: 137 GNYTCIVENEYGSINHTYQLDV 158
G Y C N+ GS+ + L V
Sbjct: 727 GVYHCKATNQKGSVESSAYLTV 748
Score = 35.0 bits (79), Expect = 0.25
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 126 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 179
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
Query: 180 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 239
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
Query: 240 RNVSFEDAGEYTCL 253
++V+ EDAG YT L
Sbjct: 393 KDVTEEDAGNYTIL 406
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 269 bits (688), Expect = 6e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 125 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 182
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 183 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 241
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
Query: 242 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 301
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
Query: 302 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 353
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
Query: 354 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 383
+ P L TP+L G + Y+ + P +E
Sbjct: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
Query: 384 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 414
LP D RL GK LG G FG+VV A A GL K
Sbjct: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
Query: 415 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 474
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
Query: 475 ASKGNLREYLQARR--------------------------------------PPGLEYC- 495
G+L +L+ +R PG+ Y
Sbjct: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
Query: 496 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 534
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
Query: 535 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 594
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
Query: 595 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 653
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
Query: 654 QRPTFKQLVEDLDRIVALTSNQEYLDLS 681
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 375 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 434
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
Query: 435 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 472
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 473 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 499
E + + EY+ + PG+ Y
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
Query: 500 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 552
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
Query: 553 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 612
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
Query: 613 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
Query: 672 TSNQEYLDLS 681
++N Y +L+
Sbjct: 931 STNHIYSNLA 940
Score = 37.0 bits (84), Expect = 0.065
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 125 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 182
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 183 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 241
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
Query: 242 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 295
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 250 bits (638), Expect = 4e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 395 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 454
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
Query: 455 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 514
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
Query: 515 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 574
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
Query: 575 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 634
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
Query: 635 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 682
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (622), Expect = 3e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 395 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 454
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 455 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 514
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 515 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 574
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
Query: 575 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 634
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 635 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 669
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,255,199
Number of Sequences: 37866
Number of extensions: 1559028
Number of successful extensions: 13939
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 410
Number of HSP's that attempted gapping in prelim test: 7548
Number of HSP's gapped (non-prelim): 3368
length of query: 733
length of database: 18,247,518
effective HSP length: 110
effective length of query: 623
effective length of database: 14,082,258
effective search space: 8773246734
effective search space used: 8773246734
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.