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Search of human proteins with 45505130
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
(1235 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 2476 0.0
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 1476 0.0
gi|45439370 TAO kinase 1 [Homo sapiens] 1077 0.0
gi|148746218 TAO kinase 3 [Homo sapiens] 932 0.0
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 229 2e-59
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 228 4e-59
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 228 4e-59
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 228 4e-59
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 228 4e-59
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 227 6e-59
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 227 6e-59
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 227 6e-59
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 225 2e-58
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 222 1e-57
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 222 1e-57
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 221 3e-57
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 221 3e-57
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 221 4e-57
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 218 4e-56
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 210 6e-54
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 207 5e-53
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 207 5e-53
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 207 5e-53
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 207 5e-53
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 207 7e-53
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 206 1e-52
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 206 1e-52
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 206 1e-52
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 200 6e-51
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 199 1e-50
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 2476 bits (6418), Expect = 0.0
Identities = 1235/1235 (100%), Positives = 1235/1235 (100%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
Sbjct: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
Query: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
Sbjct: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
Sbjct: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
Sbjct: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
Query: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
Sbjct: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
Query: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
Sbjct: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
Query: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
Sbjct: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
Sbjct: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
Query: 721 NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ 780
NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ
Sbjct: 721 NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ 780
Query: 781 EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW 840
EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW
Sbjct: 781 EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW 840
Query: 841 GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE 900
GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE
Sbjct: 841 GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE 900
Query: 901 EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG 960
EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG
Sbjct: 901 EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG 960
Query: 961 SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL 1020
SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL
Sbjct: 961 SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL 1020
Query: 1021 AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG 1080
AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG
Sbjct: 1021 AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG 1080
Query: 1081 ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT 1140
ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT
Sbjct: 1081 ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT 1140
Query: 1141 QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR 1200
QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR
Sbjct: 1141 QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR 1200
Query: 1201 SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR 1235
SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR
Sbjct: 1201 SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR 1235
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 1476 bits (3822), Expect = 0.0
Identities = 744/744 (100%), Positives = 744/744 (100%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
Sbjct: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
Query: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
Sbjct: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
Sbjct: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
Sbjct: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
Query: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
Sbjct: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
Query: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
Sbjct: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
Query: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
Sbjct: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
Sbjct: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
Query: 721 NKRREQELRQKHAAQVRQQPKSLK 744
NKRREQELRQKHAAQVRQQPKSLK
Sbjct: 721 NKRREQELRQKHAAQVRQQPKSLK 744
Score = 42.7 bits (99), Expect = 0.002
Identities = 83/356 (23%), Positives = 140/356 (39%), Gaps = 68/356 (19%)
Query: 477 RQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGE--REE--------------- 519
+Q Q E+ LR Q ++ RQ+++++L L + RE+
Sbjct: 621 QQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALL 680
Query: 520 ---HSARLQRELEAQRAGFGAEAEKLARRHQA-IGEKEARAAQAEERKFQQHILGQQKKE 575
H A + EL +A AE +HQ +G + + E+ Q+H
Sbjct: 681 LRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKH-------- 732
Query: 576 LAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRR- 634
AA + Q ++ K ++ Q+K++ QE T K + ++ + L+ + LL+R
Sbjct: 733 -AAQVRQQPKSLKSKELQIKKQFQE---TCKIQTRQYKALRAHLLETTPKAQHKSLLKRL 788
Query: 635 ---QRQYFELQCRQYKRKM--LLARHSLDQDLLRE---DLNKKQTQKDLECALLLR---- 682
Q + + QY + + +L+ +L D +E ++Q Q++LE +
Sbjct: 789 KEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIK 848
Query: 683 -----QHE-ATRELE----LRQLQAVQRTRAELTRLQ--HQTELGNQLEYNKRREQELRQ 730
QHE RELE LR+ QR EL LQ + + LE R+ +E+
Sbjct: 849 IRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLE---RQAREIEA 905
Query: 731 KHAAQVRQQPKSLK---VRAGQRPPGLPLPIPGALGP----PNTGTPIEQQPCSPG 779
A +R S+ + A G P P P P P +G P PG
Sbjct: 906 FDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPG 961
Score = 35.4 bits (80), Expect = 0.34
Identities = 71/333 (21%), Positives = 131/333 (39%), Gaps = 56/333 (16%)
Query: 457 RAYCRNRDHFATIRTASLVSRQIQEHEQ-DSALREQLSGYKRMRRQHQKQLLALESRLRG 515
+A R R ++ + + Q++ +++ + LR++ + RQ K L + E +++
Sbjct: 696 QAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQK---HAAQVRQQPKSLKSKELQIKK 752
Query: 516 EREEHSARLQRELEAQRAGFGAEAEKLARRH--QAIGEKEARAAQAEERKFQQHILGQQK 573
+ +E R+ +A RA K + + + E++ R ++ Q I
Sbjct: 753 QFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLS 812
Query: 574 KELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLR 633
+ L E Q+ ++ ++QL++EL+ LL + + + E +
Sbjct: 813 SQALRLDETQEAEFQALRQQLQQELE-------------LLNAYQSKIKIRTESQ----- 854
Query: 634 RQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELR 693
+R+ EL+ R R+ LL + ++++LL AL + E R L R
Sbjct: 855 HERELRELEQRVALRRALLEQR-VEEELL---------------ALQTGRSERIRSLLER 898
Query: 694 QLQAVQRTRAELTRLQHQTEL--GNQLEYNKRREQELRQKHAAQVRQQPKS-LKVRAGQR 750
Q + ++ AE RL + G E + A R P+S G
Sbjct: 899 QAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPP 958
Query: 751 PPGLPLPI------------PGALGPP-NTGTP 770
PPG+P P P LGPP +GTP
Sbjct: 959 PPGMPPPAWRQPSLLAPPGPPNWLGPPTQSGTP 991
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 1077 bits (2785), Expect = 0.0
Identities = 542/744 (72%), Positives = 619/744 (83%), Gaps = 28/744 (3%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
MP+ RAGSLKDP++AELFFK+DPEKLF+DLREIGHGSFGAVYFARDVR +EVVAIKKMS
Sbjct: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
Query: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQS EKWQDIIKEV+FLQ+++HPN+I+Y+GCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
KPLQEVEIAA+THGALQGLAYLHSH MIHRD+KAGNILL+EPG VKL DFGSAS+ +PAN
Sbjct: 121 KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
ESP LQS WS+YFRNFVDSCLQKIPQDRPTSE LLKH FVLRERP TV++DLIQRTKDA
Sbjct: 241 ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
VRELDNLQYRKMKK+LFQEA NGP EA EEEEE + + R GT+ S+ S+ S+PSMSIS
Sbjct: 301 VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS 360
Query: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
ASSQSSSVNSL D SD++ E + M EG+HTV S+SS+IH P
Sbjct: 361 ASSQSSSVNSLPDVSDDKSELD-------------------MMEGDHTVMSNSSVIHLKP 401
Query: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
+N Y+ E P A P S +R +++ RNR+HFATIRTASLV+RQ+Q
Sbjct: 402 EEEN-----YREEGDPR----TRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQ 452
Query: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
EHEQDS LREQ+SGYKRMRRQHQKQL+ LE++L+ E +EH RL ++LE QR F AE E
Sbjct: 453 EHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEME 512
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
KL ++HQA EKEA+ EE+KFQQHI QQKKEL + LE+QKR YKLRKEQLKEEL E
Sbjct: 513 KLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNE 572
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
N STPK+EK EWL +QKE +Q QAEEEA LLRRQRQY EL+CR++KR+MLL RH+L+QD
Sbjct: 573 NQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQD 632
Query: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
L+RE+LNK+QTQKDLE A+LLRQHE+ +ELE R L +Q+ R EL RLQHQTEL NQLEY
Sbjct: 633 LVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEY 692
Query: 721 NKRREQELRQKHAAQVRQQPKSLK 744
NKRRE+ELR+KH +VRQQPKSLK
Sbjct: 693 NKRRERELRRKHVMEVRQQPKSLK 716
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 932 bits (2410), Expect = 0.0
Identities = 468/739 (63%), Positives = 578/739 (78%), Gaps = 27/739 (3%)
Query: 6 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65
R G LKDP++A+LF+KDDPE+LF L EIGHGSFGAVYFA + SEVVAIKKMSYSGKQ
Sbjct: 2 RKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQ 61
Query: 66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 125
++EKWQDI+KEV+FL++L+HPNTI+Y+GCYL+EHTAWLVMEYCLGSASDLLEVHKKPLQE
Sbjct: 62 THEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQE 121
Query: 126 VEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGT 185
VEIAA+THGAL GLAYLHSH +IHRD+KAGNILL+EPG VKL DFGSAS+ +PANSFVGT
Sbjct: 122 VEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 181
Query: 186 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL 245
PYWMAPEVILAMDEGQYDGKVD+WSLGITCIELAERKPPLFNMNAMSALYHIAQN+SP L
Sbjct: 182 PYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL 241
Query: 246 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELD 305
QS W++ FR FVD CLQKIPQ+RPTS LL+H FV R+RP V++DLIQRTKDAVRELD
Sbjct: 242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELD 301
Query: 306 NLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQS 365
NLQYRKMKKILFQE NGP E+ E+EE++E + SL S+HS+PSMS+S SQS
Sbjct: 302 NLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361
Query: 366 SSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNL 425
SSVNS+ + D + E+ MM + E T+ S SS++H+ D++
Sbjct: 362 SSVNSMQEVMDE-----------------SSSELVMMHDDESTINSSSSVVHK---KDHV 401
Query: 426 YDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQD 485
+ P P P PT + S + + RNR+ FATI++ASLV+RQI EHEQ+
Sbjct: 402 FIRDEAGHGDPRP-----EPRPTQSVQS--QALHYRNRERFATIKSASLVTRQIHEHEQE 454
Query: 486 SALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARR 545
+ LREQ+SGYKRMRRQHQKQL+ALE++L+ E +EH +LQ+E+E E EKLA++
Sbjct: 455 NELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKK 514
Query: 546 HQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTP 605
AI EKEA+ A A+E+KFQQ IL QQKK+L LE+QK+ YK+ KE++KEE+ E+ STP
Sbjct: 515 QVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTP 574
Query: 606 KREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLRED 665
K+EK E + + KE LQ QAEEEA LL +QR Y++ CR +KRK+++ RH ++Q +RE+
Sbjct: 575 KKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREE 634
Query: 666 LNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRRE 725
LNKK+TQK++E A+L+R E+TRELE RQL +Q+ R +L RLQHQTEL NQLEYNKRRE
Sbjct: 635 LNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRE 694
Query: 726 QELRQKHAAQVRQQPKSLK 744
+EL +KH ++RQQPK+LK
Sbjct: 695 RELHRKHVMELRQQPKNLK 713
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 229 bits (583), Expect = 2e-59
Identities = 210/818 (25%), Positives = 371/818 (45%), Gaps = 121/818 (14%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DP +++ + E+G G+FG VY A++ + A K + +S E+ +D I E+ L
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAY 141
HP ++ G Y + W+++E+C G A D + + + L E +I V L+ L +
Sbjct: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS----IMAPANSFVGTPYWMAPEVILA- 196
LHS +IHRD+KAGN+L++ G ++L DFG ++ + +SF+GTPYWMAPEV++
Sbjct: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
Query: 197 -MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESP-VLQSGHWSEYF 254
M + YD K D+WSLGIT IE+A+ +PP +N M L IA+++ P +L WS F
Sbjct: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
Query: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFV--------LRE---RPPTVIMDLIQRTKDAVRE 303
R+F+ L K P+ RP++ LL+H FV LRE +M+ I+ +D E
Sbjct: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEE 327
Query: 304 LDNLQYRKMKKILFQE----APNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSI 359
D + + Q +P A+ P EE + P + + + S+ S PS
Sbjct: 328 EDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTP-LAPSQSQDSVNEPCSQPSG-- 384
Query: 360 SASSQSSSVNSLADASDN----------------EEEEEEEEEEEEEEEGPEAREMAMMQ 403
S Q++S +A ++N + + +E++ E+G + A
Sbjct: 385 DRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRS 444
Query: 404 EGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPP--AAPAPTSTTSSARRRAYCR 461
+ +SS + L G ++ L+PP AAP P+ S
Sbjct: 445 QKASQSRPNSSALETLGGE----------KLANGSLEPPAQAAPGPSKRDSDCSSLCTSE 494
Query: 462 NRDH----------------------------------------FATIRTASLVSRQIQE 481
+ D+ +I T+ ++S ++
Sbjct: 495 SMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKK 554
Query: 482 HEQDSALREQ-LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
E+ LR Q L + ++++ + L ++ + E+ R ++E+ A++ F E E
Sbjct: 555 DEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELE 614
Query: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
L R+ + EK + R+ + I +Q ++ E KL K+++K E+++
Sbjct: 615 NLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQE----QLKLMKKEVKNEVEK 670
Query: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
P++++ E + ++ E+ Q + + + +Q++ EL ++ R D++
Sbjct: 671 ---LPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDN--RREICDKE 725
Query: 661 LLREDLNKKQ-TQKDLECALL-LRQHEATRELELRQLQAVQR---TRAELTRLQHQTELG 715
RE L KKQ +D E AL + +H+ +L + Q + R EL R +H+ E
Sbjct: 726 --RECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR-KHEKERE 782
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPG 753
YN+R ++L+ VRQQ + ++ QR G
Sbjct: 783 QMQRYNQRMIEQLK------VRQQQEKARLPKIQRSEG 814
Score = 53.5 bits (127), Expect = 1e-06
Identities = 84/406 (20%), Positives = 166/406 (40%), Gaps = 59/406 (14%)
Query: 380 EEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSD---------NLYDDPY 430
E+E+++EE E RE+ ++Q+ EH + S H L N +
Sbjct: 550 EDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFF 609
Query: 431 QPEITPSPLQPPAAPAPTSTTSSARRRAYCR------NRDHFATIRTASLVSRQIQEHEQ 484
E+ Q + RRR R +RD+ L+ ++++ +
Sbjct: 610 DTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVE 669
Query: 485 DSALREQLSGYKRMRRQH--QKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKL 542
+++ K+ +H +KQLL + + + + A + + +R E E L
Sbjct: 670 KLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECL 729
Query: 543 ARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEE--LQE 600
++ + + ++EA + EE + Q+ ++L K+QLK++ LQ
Sbjct: 730 MKKQELLRDREAALWEMEEHQLQER-------------------HQLVKQQLKDQYFLQR 770
Query: 601 NPSTPKREKAEWLL-----RQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL--- 652
+ K EK + R EQL+ Q +E+A L + QR + + YK+ + +
Sbjct: 771 HELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGG 830
Query: 653 -----ARHSLDQDLLREDLNKK--QTQKDLECALLLRQHEATRELELRQLQAVQRTRAEL 705
R + Q +E+ +K + Q+ + +R A E + +LQ +Q + L
Sbjct: 831 GSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL 890
Query: 706 TRLQHQTELGNQL-EYNKRREQELRQKHAAQVRQQPKSLKVRAGQR 750
++H+T+ L E + + +E R K +R + K+L+ Q+
Sbjct: 891 L-VEHETQKLKALDESHNQNLKEWRDK----LRPRKKALEEDLNQK 931
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 228 bits (580), Expect = 4e-59
Identities = 202/677 (29%), Positives = 317/677 (46%), Gaps = 121/677 (17%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAI 549
+ + Q+Q L+ +L+ ER+ +H + QR +E + E + + + I
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 550 GEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR 607
A +Q Q + Q K L+ EA T Q + ENP P R
Sbjct: 538 PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTR 597
Query: 608 ----EKAEWLLRQKEQL 620
+++ W LRQ+E +
Sbjct: 598 IEKFDRSSW-LRQEEDI 613
Score = 50.4 bits (119), Expect = 1e-05
Identities = 92/371 (24%), Positives = 142/371 (38%), Gaps = 63/371 (16%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ E QR
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE---EQQRR--- 411
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
EKE R Q ER+ ++H Q ++ E ++R + +E ++
Sbjct: 412 --------------EKELRKQQ--EREQRRHYEEQMRR------EEERRRAEHEQEYIRR 449
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHS 656
+L+E RQ E LQQ E+A LL +R+ E Q RQ +R L +
Sbjct: 450 QLEEEQ------------RQLEILQQQLLHEQALLLEYKRKQLEEQ-RQAER--LQRQLK 494
Query: 657 LDQDLLREDLNKKQTQKDLECALLLRQHEATR-------ELELRQLQAVQRTRAELTRLQ 709
++D L +++Q Q+ +E L E E+ L AV+ LT Q
Sbjct: 495 QERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQ 554
Query: 710 HQTE--------LGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGL--PLPIP 759
E L R + RQ P ++ R L IP
Sbjct: 555 SVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIP 614
Query: 760 GALGPPNTG-TPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILG 818
+ T +P + SPG + L R LG + + E P Q+ G
Sbjct: 615 PKVPQRTTSISPALARKNSPGNGSALGPR-LGSQPIRASNPDLRRTEPILESPLQRTSSG 673
Query: 819 EESGAPSPSPQ 829
S + +PS Q
Sbjct: 674 SSSSSSTPSSQ 684
Score = 33.9 bits (76), Expect = 0.99
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 5/146 (3%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELT 706
++ LLA + +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEERR 438
Query: 707 RLQHQTE-LGNQLEYNKRREQELRQK 731
R +H+ E + QLE +R+ + L+Q+
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQ 464
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 228 bits (580), Expect = 4e-59
Identities = 202/677 (29%), Positives = 317/677 (46%), Gaps = 121/677 (17%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAI 549
+ + Q+Q L+ +L+ ER+ +H + QR +E + E + + + I
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 550 GEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR 607
A +Q Q + Q K L+ EA T Q + ENP P R
Sbjct: 538 PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTR 597
Query: 608 ----EKAEWLLRQKEQL 620
+++ W LRQ+E +
Sbjct: 598 IEKFDRSSW-LRQEEDI 613
Score = 53.5 bits (127), Expect = 1e-06
Identities = 100/450 (22%), Positives = 180/450 (40%), Gaps = 62/450 (13%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCR 644
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L + +
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKP 531
Query: 645 QYKRKM--LLARHSLDQDLLREDLNKKQTQKDL---ECALLLRQHEATRELELRQLQAVQ 699
+ +++ L+A S L +Q K L + AL + H E+ +
Sbjct: 532 AWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRV--EMPRQNSDPTS 589
Query: 700 RTRAELTRLQ---HQTELGNQLEYNKRREQELRQKHAAQVRQQP----KSLKVRAGQRP- 751
TR++ + L + + + Q A R+ +L R G +P
Sbjct: 590 ENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPI 649
Query: 752 -----------PGLPLPIP-GALGPPNTGTPIEQQPCS-----PGQEAVLDQRMLGEEEE 794
P L P+ + G ++ + QP S PG +A +R
Sbjct: 650 RASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANS 709
Query: 795 AVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSL 854
+L E A ++P++ R + S P + +DE++ L +E+ ELR+
Sbjct: 710 KSEGSPVLPHEPAKVKPEESRDITRPS-----RPASYKKAIDEDLTALAKELRELRI--- 761
Query: 855 VPQERSIVGQEEAGTWSLWGKEDESLLDEE 884
E + ++ +S +E ES +EE
Sbjct: 762 ---EETNRPMKKVTDYSSSSEESESSEEEE 788
Score = 46.6 bits (109), Expect = 1e-04
Identities = 91/386 (23%), Positives = 142/386 (36%), Gaps = 66/386 (17%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKRE--------KAEWLLRQKEQ-------LQQCQAEEEAGLLRRQRQYFEL 641
+ + +RE + E++ RQ E+ LQQ E+A LL +R+ E
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEE 482
Query: 642 QCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATR-------ELELRQ 694
Q RQ +R L + ++D L +++Q Q+ +E L E E+
Sbjct: 483 Q-RQAER--LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPH 539
Query: 695 LQAVQRTRAELTRLQHQTE--------LGNQLEYNKRREQELRQKHAAQVRQQPKSLKVR 746
L AV+ LT Q E L R + RQ P ++
Sbjct: 540 LVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIE 599
Query: 747 AGQRPPGL--PLPIPGALGPPNTG-TPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILG 803
R L IP + T +P + SPG + L R LG + +
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPR-LGSQPIRASNPDLRR 658
Query: 804 KEGATLEPKQQRILGEESGAPSPSPQ 829
E P Q+ G S + +PS Q
Sbjct: 659 TEPILESPLQRTSSGSSSSSSTPSSQ 684
Score = 33.9 bits (76), Expect = 0.99
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 5/146 (3%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELT 706
++ LLA + +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEERR 438
Query: 707 RLQHQTE-LGNQLEYNKRREQELRQK 731
R +H+ E + QLE +R+ + L+Q+
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQ 464
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 228 bits (580), Expect = 4e-59
Identities = 130/284 (45%), Positives = 178/284 (62%), Gaps = 14/284 (4%)
Query: 21 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 80
K DPE+LF+ L +IG GSFG V+ D R +VVAIK + +++ ++ +DI +E+ L
Sbjct: 17 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 74
Query: 81 QKLRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGL 139
+ P +Y G YL++ W++MEY G SA DLLE PL E +IA + L+GL
Sbjct: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 132
Query: 140 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVIL 195
YLHS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 191
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFR 255
+ YD K D+WSLGIT IELA +PP ++ M L+ I +N P L+ G++S+ +
Sbjct: 192 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GNYSKPLK 248
Query: 256 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPT-VIMDLIQRTK 298
FV++CL K P RPT++ LLKH+F+LR T + +LI R K
Sbjct: 249 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 292
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 228 bits (580), Expect = 4e-59
Identities = 130/284 (45%), Positives = 178/284 (62%), Gaps = 14/284 (4%)
Query: 21 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 80
K DPE+LF+ L +IG GSFG V+ D R +VVAIK + +++ ++ +DI +E+ L
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 86
Query: 81 QKLRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGL 139
+ P +Y G YL++ W++MEY G SA DLLE PL E +IA + L+GL
Sbjct: 87 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 144
Query: 140 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVIL 195
YLHS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 203
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFR 255
+ YD K D+WSLGIT IELA +PP ++ M L+ I +N P L+ G++S+ +
Sbjct: 204 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GNYSKPLK 260
Query: 256 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPT-VIMDLIQRTK 298
FV++CL K P RPT++ LLKH+F+LR T + +LI R K
Sbjct: 261 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 304
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 227 bits (578), Expect = 6e-59
Identities = 191/609 (31%), Positives = 294/609 (48%), Gaps = 116/609 (19%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKE 553
+ + Q+Q L+ +L+ ER ++ LQ + + QR EK H G EK
Sbjct: 478 KQLEEQRQAERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKP 531
Query: 554 ARAAQAEER 562
A A + EER
Sbjct: 532 AWAKEVEER 540
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 19/167 (11%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL 631
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 46.6 bits (109), Expect = 1e-04
Identities = 65/294 (22%), Positives = 116/294 (39%), Gaps = 66/294 (22%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHS 656
+ +R E + R++E+ +AE E +RRQ + + ++ +L +
Sbjct: 423 Q--------RRHYEEQMRREEERR---RAEHEQEYIRRQLE------EEQRQLEILQQQL 465
Query: 657 LDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGN 716
L + L + +KQ ++ + L RQ +++ R L LQHQ +
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQ--------------LKQERDYLVSLQHQRQEQR 511
Query: 717 QLE----YNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPN 766
+E Y+ + +K A + +S R Q P +P + + PN
Sbjct: 512 PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNR--QSSPAMPHKVANRISDPN 563
Score = 42.0 bits (97), Expect = 0.004
Identities = 59/253 (23%), Positives = 96/253 (37%), Gaps = 33/253 (13%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E R E +L Q +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLH 467
Query: 552 KEA-----RAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPK 606
++A + Q EE++ + + Q K+E L+ Q + + R + K
Sbjct: 468 EQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSP 527
Query: 607 REKAEWLLRQKEQ 619
EK W +E+
Sbjct: 528 SEKPAWAKEVEER 540
Score = 33.9 bits (76), Expect = 0.99
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 5/146 (3%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELT 706
++ LLA + +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEERR 438
Query: 707 RLQHQTE-LGNQLEYNKRREQELRQK 731
R +H+ E + QLE +R+ + L+Q+
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQ 464
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 227 bits (578), Expect = 6e-59
Identities = 191/609 (31%), Positives = 294/609 (48%), Gaps = 116/609 (19%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHE------QDSALREQ--LSGYKR 497
RRRA +H + RQ++E + Q L EQ L YKR
Sbjct: 435 -------EERRRA-----EH-----EQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKR 477
Query: 498 MRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKE 553
+ + Q+Q L+ +L+ ER ++ LQ + + QR EK H G EK
Sbjct: 478 KQLEEQRQAERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKP 531
Query: 554 ARAAQAEER 562
A A + EER
Sbjct: 532 AWAKEVEER 540
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 19/167 (11%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E Q EE + Q IL QQ LL Q
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ------LLHEQAL 471
Query: 586 TYKLRKEQLKEELQ-ENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL 631
+ +++QL+E+ Q E +++ ++L+ + Q Q+ + E+ L
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Score = 46.6 bits (109), Expect = 1e-04
Identities = 65/294 (22%), Positives = 116/294 (39%), Gaps = 66/294 (22%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHS 656
+ +R E + R++E+ +AE E +RRQ + + ++ +L +
Sbjct: 423 Q--------RRHYEEQMRREEERR---RAEHEQEYIRRQLE------EEQRQLEILQQQL 465
Query: 657 LDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGN 716
L + L + +KQ ++ + L RQ +++ R L LQHQ +
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQ--------------LKQERDYLVSLQHQRQEQR 511
Query: 717 QLE----YNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPN 766
+E Y+ + +K A + +S R Q P +P + + PN
Sbjct: 512 PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNR--QSSPAMPHKVANRISDPN 563
Score = 42.0 bits (97), Expect = 0.004
Identities = 59/253 (23%), Positives = 96/253 (37%), Gaps = 33/253 (13%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E R E +L Q +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLH 467
Query: 552 KEA-----RAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPK 606
++A + Q EE++ + + Q K+E L+ Q + + R + K
Sbjct: 468 EQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSP 527
Query: 607 REKAEWLLRQKEQ 619
EK W +E+
Sbjct: 528 SEKPAWAKEVEER 540
Score = 33.9 bits (76), Expect = 0.99
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 5/146 (3%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELT 706
++ LLA + +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEERR 438
Query: 707 RLQHQTE-LGNQLEYNKRREQELRQK 731
R +H+ E + QLE +R+ + L+Q+
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQ 464
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 227 bits (578), Expect = 6e-59
Identities = 134/391 (34%), Positives = 212/391 (54%), Gaps = 31/391 (7%)
Query: 24 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 83
PE++F L ++G GS+G+V+ A + +VVAIK++ Q+IIKE+ +Q+
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-----QEIIKEISIMQQC 77
Query: 84 RHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
P ++Y G Y + W+VMEYC GS SD++ + K L E EIA + L+GL YL
Sbjct: 78 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYL 137
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMD 198
H IHRD+KAGNILL+ G KL DFG A MA N+ +GTP+WMAPEVI
Sbjct: 138 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---Q 194
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGH-WSEYFRNF 257
E Y+ D+WSLGIT IE+AE KPP +++ M A++ I N P + WS+ F +F
Sbjct: 195 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDF 254
Query: 258 VDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILF 317
V CL K P+ R T+ LL+H F+ +P +++ DLI + + Q R++++
Sbjct: 255 VKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEE--- 311
Query: 318 QEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADAS-- 375
E +E+E + + ++ S+ + + +MS A + +++ ++
Sbjct: 312 --------EEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLG 363
Query: 376 ----DNEEEEEEEEEEEEEEEGPEAREMAMM 402
++E+EEEE+ + P+ + + M
Sbjct: 364 TMVINSEDEEEEDGTMKRNATSPQVQRPSFM 394
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 225 bits (573), Expect = 2e-58
Identities = 139/389 (35%), Positives = 206/389 (52%), Gaps = 34/389 (8%)
Query: 24 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 83
PE++F L ++G GS+G+VY A ++VAIK++ Q+IIKE+ +Q+
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDL-----QEIIKEISIMQQC 80
Query: 84 RHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
P+ ++Y G Y + W+VMEYC GS SD++ + K L E EIA + L+GL YL
Sbjct: 81 DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYL 140
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMD 198
H IHRD+KAGNILL+ G KL DFG A MA N+ +GTP+WMAPEVI
Sbjct: 141 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---Q 197
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGH-WSEYFRNF 257
E Y+ D+WSLGIT IE+AE KPP +++ M A++ I N P + WS+ F +F
Sbjct: 198 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDF 257
Query: 258 VDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILF 317
V CL K P+ R T+ LL+H FV + +++ DLI D + Q R++ +
Sbjct: 258 VKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQ--- 314
Query: 318 QEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDN 377
++EE +E +GT+ + ++ + AS+ + N++ + D
Sbjct: 315 ------------DDEENSEEDEMDSGTMVRAVGD-EMGTVRV-ASTMTDGANTMIEHDDT 360
Query: 378 EEEEEEE---EEEEEEEEGPEAREMAMMQ 403
+ E+EEEEG R MQ
Sbjct: 361 LPSQLGTMVINAEDEEEEGTMKRRDETMQ 389
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 222 bits (566), Expect = 1e-57
Identities = 197/669 (29%), Positives = 308/669 (46%), Gaps = 134/669 (20%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAIGEKEARAA 557
L+ +L+ ER+ +H + QR +E + E + + + I A +
Sbjct: 457 AERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKS 516
Query: 558 QAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR----EKAE 611
Q Q + Q K L+ EA T Q + ENP P R +++
Sbjct: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
Query: 612 WLLRQKEQL 620
W LRQ+E +
Sbjct: 577 W-LRQEEDI 584
Score = 42.7 bits (99), Expect = 0.002
Identities = 84/371 (22%), Positives = 133/371 (35%), Gaps = 65/371 (17%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHS 656
+ + +RE+ +++ ++ Q EE QRQ LQ RQ K+
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEE-------QRQAERLQ-RQLKQ-------- 466
Query: 657 LDQDLLREDLNKKQTQKDLECALLLRQHEATR-------ELELRQLQAVQRTRAELTRLQ 709
++D L +++Q Q+ +E L E E+ L AV+ LT Q
Sbjct: 467 -ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQ 525
Query: 710 HQTE--------LGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGL--PLPIP 759
E L R + RQ P ++ R L IP
Sbjct: 526 SVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIP 585
Query: 760 GALGPPNTG-TPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILG 818
+ T +P + SPG + L R LG + + E P Q+ G
Sbjct: 586 PKVPQRTTSISPALARKNSPGNGSALGPR-LGSQPIRASNPDLRRTEPILESPLQRTSSG 644
Query: 819 EESGAPSPSPQ 829
S + +PS Q
Sbjct: 645 SSSSSSTPSSQ 655
Score = 35.0 bits (79), Expect = 0.44
Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 6/166 (3%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELT 706
++ LLA + +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEERR 438
Query: 707 RLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK-VRAGQRP 751
R +H+ E + + ++R+ E Q+ Q R SL+ R QRP
Sbjct: 439 RAEHEQEY-KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP 483
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 222 bits (566), Expect = 1e-57
Identities = 197/669 (29%), Positives = 308/669 (46%), Gaps = 134/669 (20%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGERE-----EHSARLQRELEAQRAGFGAEAEKLARR---HQAIGEKEARAA 557
L+ +L+ ER+ +H + QR +E + E + + + I A +
Sbjct: 457 AERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKS 516
Query: 558 QAEERKFQQHILGQQKKELAALLEAQKRTYKL--RKEQLKEELQENPSTPKR----EKAE 611
Q Q + Q K L+ EA T Q + ENP P R +++
Sbjct: 517 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 576
Query: 612 WLLRQKEQL 620
W LRQ+E +
Sbjct: 577 W-LRQEEDI 584
Score = 54.3 bits (129), Expect = 7e-07
Identities = 88/427 (20%), Positives = 159/427 (37%), Gaps = 45/427 (10%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELEA-- 530
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 531 -----QRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E + Q EE++ + + Q K+E L+ Q +
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQ 477
Query: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQ 645
+ R + K EK W KE + + L + E +
Sbjct: 478 RQEQRPVEKKPLYHYKEGMSPSEKPAWA---KEIPHLVAVKSQGPALTASQSVHEQPTKG 534
Query: 646 ---YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAV---- 698
++ + + H ++ D + L R + R LRQ + +
Sbjct: 535 LSGFQEALNVTSHRVEMPRQNSDPTSENPP------LPTRIEKFDRSSWLRQEEDIPPKV 588
Query: 699 -QRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLP 757
QRT + L + GN R + + +R+ L+ + G
Sbjct: 589 PQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSG---- 644
Query: 758 IPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRIL 817
+ + P Q PG +A +R +L E A ++P++ R +
Sbjct: 645 -SSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDI 703
Query: 818 GEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKED 877
S P + +DE++ L +E+ ELR+ E + ++ +S +E
Sbjct: 704 TRPS-----RPASYKKAIDEDLTALAKELRELRI------EETNRPMKKVTDYSSSSEES 752
Query: 878 ESLLDEE 884
ES +EE
Sbjct: 753 ESSEEEE 759
Score = 42.7 bits (99), Expect = 0.002
Identities = 84/371 (22%), Positives = 133/371 (35%), Gaps = 65/371 (17%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHS 656
+ + +RE+ +++ ++ Q EE QRQ LQ RQ K+
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEE-------QRQAERLQ-RQLKQ-------- 466
Query: 657 LDQDLLREDLNKKQTQKDLECALLLRQHEATR-------ELELRQLQAVQRTRAELTRLQ 709
++D L +++Q Q+ +E L E E+ L AV+ LT Q
Sbjct: 467 -ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQ 525
Query: 710 HQTE--------LGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGL--PLPIP 759
E L R + RQ P ++ R L IP
Sbjct: 526 SVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIP 585
Query: 760 GALGPPNTG-TPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILG 818
+ T +P + SPG + L R LG + + E P Q+ G
Sbjct: 586 PKVPQRTTSISPALARKNSPGNGSALGPR-LGSQPIRASNPDLRRTEPILESPLQRTSSG 644
Query: 819 EESGAPSPSPQ 829
S + +PS Q
Sbjct: 645 SSSSSSTPSSQ 655
Score = 35.0 bits (79), Expect = 0.44
Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 6/166 (3%)
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
Y +E+ +E PS+ E LR+ Q +E + LRRQ+ + + +
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELT 706
++ LLA + +E + + Q+ E L +Q R R + R E
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYEEQMRREEERR 438
Query: 707 RLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK-VRAGQRP 751
R +H+ E + + ++R+ E Q+ Q R SL+ R QRP
Sbjct: 439 RAEHEQEY-KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRP 483
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 221 bits (564), Expect = 3e-57
Identities = 186/601 (30%), Positives = 285/601 (47%), Gaps = 129/601 (21%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKEARAAQAEE 561
L+ +L+ ER ++ LQ + + QR EK H G EK A A + EE
Sbjct: 457 AERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKPAWAKEVEE 510
Query: 562 R 562
R
Sbjct: 511 R 511
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E + Q EE++ + + Q K+E L+ Q +
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQ 477
Query: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQ 619
+ R + K EK W +E+
Sbjct: 478 RQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
Score = 41.6 bits (96), Expect = 0.005
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
+ + +RE+ +++ ++ Q EE+ R QRQ
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Score = 38.5 bits (88), Expect = 0.040
Identities = 67/302 (22%), Positives = 123/302 (40%), Gaps = 52/302 (17%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
++ H Q A EQL + +R Q ++ + ++ + +R + + E E + +G E
Sbjct: 271 VKNHSQRPAT-EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEE 329
Query: 539 AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL 598
E+ GE + E ++ L Q L ++R+ LR++QL+++
Sbjct: 330 EEE-----NDSGEPSSILNLPGESTLRRDFLRLQ-------LANKERSEALRRQQLEQQQ 377
Query: 599 QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL----LRRQ------RQYFELQCRQYKR 648
+EN ++ AE R +EQ +Q + EE LR+Q R Y E R+ +R
Sbjct: 378 RENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Query: 649 KMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRL 708
+ A H ++ +KQ ++ + L RQ +++ R L L
Sbjct: 438 RR--AEH-------EQEYKRKQLEEQRQAERLQRQ--------------LKQERDYLVSL 474
Query: 709 QHQTELGNQLE----YNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGP 764
QHQ + +E Y+ + +K A + +S R Q P +P + +
Sbjct: 475 QHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNR--QSSPAMPHKVANRISD 532
Query: 765 PN 766
PN
Sbjct: 533 PN 534
Score = 34.3 bits (77), Expect = 0.75
Identities = 54/241 (22%), Positives = 94/241 (39%), Gaps = 36/241 (14%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQHQK-QLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 551
K +R+Q ++ Q E ++R REE R + E E +R + + + Q E
Sbjct: 410 RREKELRKQQEREQRRHYEEQMR--REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQE 467
Query: 552 KEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLR-----KEQLKEELQENPSTPK 606
++ + +R+ Q+ + +KK L E + K +E+ + Q +P+ P
Sbjct: 468 RDYLVSLQHQRQEQRPV---EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPH 524
Query: 607 R 607
+
Sbjct: 525 K 525
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 221 bits (564), Expect = 3e-57
Identities = 186/601 (30%), Positives = 285/601 (47%), Gaps = 129/601 (21%)
Query: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
M + A SL + D++ L DP +F + +G+G++G VY R V+ ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L+K H N Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
+DL++ K L+E IA + L+GL++LH H +IHRD+K N+LL+E VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SAS----IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ + N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 284
L +M+ M AL+ I +N +P L+S WS+ F++F++SCL K RP +E L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEA-EP- 337
+P + D I RTK E D +Y G+E EEE ++ EP
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYEY------------SGSEEEEEENDSGEPS 339
Query: 338 -YMHRAG-----------TLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEE 385
++ G L + E S ++ + + + + ++ ++ EE++
Sbjct: 340 SILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK 399
Query: 386 EEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAP 445
E+ E + RE + ++ E H Y++ + E
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRH-------------YEEQMRRE------------ 434
Query: 446 APTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQ 505
RRRA EHEQ+ YKR + + Q+Q
Sbjct: 435 -------EERRRA----------------------EHEQE---------YKRKQLEEQRQ 456
Query: 506 LLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIG----EKEARAAQAEE 561
L+ +L+ ER ++ LQ + + QR EK H G EK A A + EE
Sbjct: 457 AERLQRQLKQER-DYLVSLQHQRQEQR-----PVEKKPLYHYKEGMSPSEKPAWAKEVEE 510
Query: 562 R 562
R
Sbjct: 511 R 511
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 478 QIQEHEQDSALR-EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQ----RELE--- 529
Q+ E+ ALR +QL +R +H++QLLA + E++E RL+ RE E
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 530 ----AQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKR 585
QR + + + R +A E+E + Q EE++ + + Q K+E L+ Q +
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQ 477
Query: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQ 619
+ R + K EK W +E+
Sbjct: 478 RQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
Score = 41.6 bits (96), Expect = 0.005
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%)
Query: 480 QEHEQDSALREQ---LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFG 536
+E E DS L G +RR + LA + R R + + QRE E +
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHK---- 384
Query: 537 AEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE 596
Q + E++ R + +QK++ L E Q+R +LRK+Q +E
Sbjct: 385 ---------RQLLAERQKR-------------IEEQKEQRRRLEEQQRREKELRKQQERE 422
Query: 597 ELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
+ + +RE+ +++ ++ Q EE+ R QRQ
Sbjct: 423 QRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Score = 38.5 bits (88), Expect = 0.040
Identities = 67/302 (22%), Positives = 123/302 (40%), Gaps = 52/302 (17%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
++ H Q A EQL + +R Q ++ + ++ + +R + + E E + +G E
Sbjct: 271 VKNHSQRPAT-EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEE 329
Query: 539 AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL 598
E+ GE + E ++ L Q L ++R+ LR++QL+++
Sbjct: 330 EEE-----NDSGEPSSILNLPGESTLRRDFLRLQ-------LANKERSEALRRQQLEQQQ 377
Query: 599 QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGL----LRRQ------RQYFELQCRQYKR 648
+EN ++ AE R +EQ +Q + EE LR+Q R Y E R+ +R
Sbjct: 378 RENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Query: 649 KMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRL 708
+ A H ++ +KQ ++ + L RQ +++ R L L
Sbjct: 438 RR--AEH-------EQEYKRKQLEEQRQAERLQRQ--------------LKQERDYLVSL 474
Query: 709 QHQTELGNQLE----YNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGP 764
QHQ + +E Y+ + +K A + +S R Q P +P + +
Sbjct: 475 QHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNR--QSSPAMPHKVANRISD 532
Query: 765 PN 766
PN
Sbjct: 533 PN 534
Score = 36.2 bits (82), Expect = 0.20
Identities = 104/549 (18%), Positives = 190/549 (34%), Gaps = 86/549 (15%)
Query: 378 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPS 437
+++ E++E E E G E +E E + S I LPG L D + ++
Sbjct: 310 KKKRGEKDETEYEYSGSE-------EEEEENDSGEPSSILNLPGESTLRRDFLRLQLA-- 360
Query: 438 PLQPPAAPAPTSTTSSARRRAYCR-----NRDHFATIRTASLVSRQIQEHEQDSALREQL 492
S A RR N +H + A R ++ EQ L EQ
Sbjct: 361 ----------NKERSEALRRQQLEQQQRENEEHKRQL-LAERQKRIEEQKEQRRRLEEQQ 409
Query: 493 SGYKRMRRQ--------HQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLAR 544
K +R+Q +++Q+ E R R E E+ R ++LE QR + +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR--KQLEEQRQAERLQRQLKQE 467
Query: 545 RHQAIGEKEARAAQAEERK-----FQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
R + + R Q K +++ + +K A +E + R + + ++
Sbjct: 468 RDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVA 527
Query: 600 E---NPSTPKREKA------------EWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCR 644
+P+ P R ++ L Q+ A + G Q Q
Sbjct: 528 NRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPT 587
Query: 645 Q----YKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAV-- 698
+ ++ + + H ++ D + L R + R LRQ + +
Sbjct: 588 KGLSGFQEALNVTSHRVEMPRQNSDPTSENPP------LPTRIEKFDRSSWLRQEEDIPP 641
Query: 699 ---QRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLP 755
QRT + L + GN R + + +R+ L+ + G
Sbjct: 642 KVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSG-- 699
Query: 756 LPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQR 815
+ + P Q PG +A +R +L E A ++P++ R
Sbjct: 700 ---SSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESR 756
Query: 816 ILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGK 875
+ S P + +DE++ L +E+ ELR+ E + ++ +S +
Sbjct: 757 DITRPS-----RPASYKKAIDEDLTALAKELRELRI------EETNRPMKKVTDYSSSSE 805
Query: 876 EDESLLDEE 884
E ES +EE
Sbjct: 806 ESESSEEEE 814
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 221 bits (562), Expect = 4e-57
Identities = 128/282 (45%), Positives = 176/282 (62%), Gaps = 14/282 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DPE+LF+ L IG GSFG VY D EVVAIK + +++ ++ +DI +E+ L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 72
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGLAY 141
P +Y G YL+ W++MEY G SA DLL+ PL+E IA + L+GL Y
Sbjct: 73 CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK--PGPLEETYIATILREILKGLDY 130
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAM 197
LHS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 131 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 187
Query: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNF 257
+ YD K D+WSLGIT IELA+ +PP +++ M L+ I +N P L+ H S+ F+ F
Sbjct: 188 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH-SKPFKEF 246
Query: 258 VDSCLQKIPQDRPTSEVLLKHRFVLR-ERPPTVIMDLIQRTK 298
V++CL K P+ RPT++ LLKH+F+ R + + + +LI R K
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 218 bits (554), Expect = 4e-56
Identities = 123/281 (43%), Positives = 172/281 (61%), Gaps = 12/281 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DPE+LF+ L IG GSFG V+ D R +VVAIK + +++ ++ +DI +E+ L +
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 76
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
+Y G YL+ W++MEY LG S L + P E +IA + L+GL YL
Sbjct: 77 CDSSYVTKYYGSYLKGSKLWIIMEY-LGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMD 198
HS IHRD+KA N+LLSE G VKL DFG A + N+FVGTP+WMAPEVI
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---Q 192
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFV 258
+ YD K D+WSLGIT IELA+ +PP +M+ M L+ I +N P L G +++ F+ F+
Sbjct: 193 QSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL-VGDFTKSFKEFI 251
Query: 259 DSCLQKIPQDRPTSEVLLKHRFVLRERPPT-VIMDLIQRTK 298
D+CL K P RPT++ LLKH+F+++ T + +LI R K
Sbjct: 252 DACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFK 292
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 210 bits (535), Expect = 6e-54
Identities = 183/567 (32%), Positives = 272/567 (47%), Gaps = 94/567 (16%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 AKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA ++ L+GLA+LH H++IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP---- 286
M AL+ I +N P L+S WS+ F +F++ CL K RP++E LLKH F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQ 297
Query: 287 -PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTL 345
+ D I RT+ E D +Y +E E PE+E E ++ G
Sbjct: 298 VRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGES 350
Query: 346 T-----------SLESSHSVPSMSISASSQSSSVNS-----LADASDNEEEEEEEEEEEE 389
T + E S ++ + Q LA+ E+++E+ E
Sbjct: 351 TLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE 410
Query: 390 EEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTS 449
E++ E RE QE E RL + +
Sbjct: 411 EQQRRE-REARRQQEREQRRREQEE-KRRLEELERRRKE--------------------- 447
Query: 450 TTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQD-SALREQLSGYKRMRRQHQKQLLA 508
RRRA R R + RQ++E ++ L++QL Q+Q +
Sbjct: 448 --EEERRRAEEEKR---RVEREQEYIRRQLEEEQRHLEVLQQQLL---------QEQAML 493
Query: 509 LESRLRGEREEH--SARLQRELEAQRA 533
LE R R E EEH + RLQR+L+ ++A
Sbjct: 494 LECRWR-EMEEHRQAERLQRQLQQEQA 519
Score = 58.9 bits (141), Expect = 3e-08
Identities = 52/176 (29%), Positives = 88/176 (50%), Gaps = 17/176 (9%)
Query: 538 EAEKLARRHQAIGEKEARAAQAEERKF---QQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E + RR Q + E++ R + +R+ +Q + QQK++ L E Q+R + R++Q
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+E+ + KR E R+KE+ ++ +AEEE + R+++Y Q + +R +
Sbjct: 425 REQ-RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL---- 479
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQH 710
L Q LL+E LEC R+ E R+ E Q Q +Q+ +A L LQH
Sbjct: 480 EVLQQQLLQEQAML------LECR--WREMEEHRQAERLQRQ-LQQEQAYLLSLQH 526
Score = 49.7 bits (117), Expect = 2e-05
Identities = 64/287 (22%), Positives = 124/287 (43%), Gaps = 21/287 (7%)
Query: 479 IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAE 538
I++ + +R QL + R+ + + E G EE ++E E
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSI-VNVP 347
Query: 539 AEKLARRH----QAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E RR Q ++ + A + ++ +Q + Q++ + L E QKR + ++++
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+ E Q+ R + E R++EQ ++ + EE L R+R+ E + R + K + R
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEE----LERRRKEEEERRRAEEEKRRVER 463
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTEL 714
+Q+ +R L ++Q ++ LL++ E R+++ + +AE RLQ Q L
Sbjct: 464 ---EQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREME--EHRQAE--RLQRQ--L 514
Query: 715 GNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGA 761
+ Y + + R+ H +Q P + R+ P P P A
Sbjct: 515 QQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERS---KPSFHAPEPKA 558
Score = 48.5 bits (114), Expect = 4e-05
Identities = 46/181 (25%), Positives = 91/181 (50%), Gaps = 11/181 (6%)
Query: 467 ATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQ--HQKQLLALESRLRGEREEHSARL 524
+T+R L +Q + ++ R+QL +++R Q +++QLLA + +++E RL
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 525 Q----RELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERK---FQQHILGQQKKELA 577
+ RE EA+R + + + + E E R + EER+ ++ + ++++ +
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR 469
Query: 578 ALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
LE ++R ++ ++QL +E RE E RQ E+LQ+ +E+A LL Q
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEH--RQAERLQRQLQQEQAYLLSLQHD 527
Query: 638 Y 638
+
Sbjct: 528 H 528
Score = 44.3 bits (103), Expect = 7e-04
Identities = 64/278 (23%), Positives = 123/278 (44%), Gaps = 19/278 (6%)
Query: 490 EQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAI 549
EQL + +R Q ++ + ++ + +R + E E + +G E E++ +
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQE--- 337
Query: 550 GEKEARAAQAEERKFQQHILG--QQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKR 607
GE + E ++ L Q+ KE + EA +R L+++QL+E+ +E
Sbjct: 338 GEPSSIVNVPGESTLRRDFLRLQQENKERS---EALRRQQLLQEQQLREQ-EEYKRQLLA 393
Query: 608 EKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLN 667
E+ + + +QKEQ ++ + ++ RR+R+ Q R+ +R+ + L++ R
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQ-----RREREARRQQEREQRRREQEEKRRLEELERRRKEE 448
Query: 668 KKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQE 727
+++ + + E + R+ E R RQL+ QR E+ + Q E LE R +E
Sbjct: 449 EERRRAEEEKRRVEREQEYIR----RQLEEEQR-HLEVLQQQLLQEQAMLLECRWREMEE 503
Query: 728 LRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPP 765
RQ Q + Q + + + Q P P PP
Sbjct: 504 HRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPP 541
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/165 (23%), Positives = 76/165 (46%), Gaps = 24/165 (14%)
Query: 659 QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRT--RAELTRLQHQTELGN 716
+ LR D + Q Q++ E + LR+ + +E +LR+ + +R R++ Q E
Sbjct: 349 ESTLRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 717 QLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPC 776
+LE +RRE+E R++ + R++ + K R + ++
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEE-------------------LERRRKEE 448
Query: 777 SPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEES 821
+ A ++R + E+E + RR L +E LE QQ++L E++
Sbjct: 449 EERRRAEEEKRRVEREQEYI--RRQLEEEQRHLEVLQQQLLQEQA 491
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 207 bits (527), Expect = 5e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/217 (24%), Positives = 96/217 (44%), Gaps = 21/217 (9%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR+ E R+ E Q + R +L + L
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALRREEERRQAEREQ----EYKRKQLEEQRQSERLQ 466
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPP 752
QL+ + L+Q+ Q Q+ + ++ G R P
Sbjct: 467 RQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP 503
Score = 43.1 bits (100), Expect = 0.002
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 207 bits (527), Expect = 5e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/217 (24%), Positives = 96/217 (44%), Gaps = 21/217 (9%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR+ E R+ E Q + R +L + L
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALRREEERRQAEREQ----EYKRKQLEEQRQSERLQ 466
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPP 752
QL+ + L+Q+ Q Q+ + ++ G R P
Sbjct: 467 RQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP 503
Score = 43.1 bits (100), Expect = 0.002
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 207 bits (527), Expect = 5e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/217 (24%), Positives = 96/217 (44%), Gaps = 21/217 (9%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR+ E R+ E Q + R +L + L
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALRREEERRQAEREQ----EYKRKQLEEQRQSERLQ 466
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPP 752
QL+ + L+Q+ Q Q+ + ++ G R P
Sbjct: 467 RQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP 503
Score = 43.1 bits (100), Expect = 0.002
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 207 bits (527), Expect = 5e-53
Identities = 153/438 (34%), Positives = 224/438 (51%), Gaps = 57/438 (13%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA + L+GLA+LH+H +IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP--- 287
M AL+ I +N P L+S WS+ F +F+D+CL K RP +E LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 288 --TVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEP--YMHRAG 343
+ D I R++ E + +Y +G E EE EP M+ G
Sbjct: 298 VRIQLKDHIDRSRKKRGEKEETEYEY----------SGSEEEDDSHGEEGEPSSIMNVPG 347
Query: 344 TLT------SLESSHSVPSMSISASSQ---------SSSVNSLADASDNEEEEEEEEEEE 388
T L+ + S ++ Q + + L EE++EE
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 389 EEEEGPEAREMAMMQEGE 406
EE+ RE +QE E
Sbjct: 408 VEEQQRREREQRKLQEKE 425
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/217 (24%), Positives = 96/217 (44%), Gaps = 21/217 (9%)
Query: 540 EKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQ 599
+ + R + GEKE + + + G++ + + + + T LR+E L+ + Q
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST--LRREFLRLQ-Q 360
Query: 600 ENPSTPKREKAEWLLRQKEQLQQCQAEEEAG----LLRRQRQYFELQCRQYKRKMLLARH 655
EN S + L+Q++QLQQ Q + LL ++++ E Q + +R R
Sbjct: 361 ENKSNSEA------LKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRR 414
Query: 656 SLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELG 715
+Q L+E K+ Q+ LE LR+ E R+ E Q + R +L + L
Sbjct: 415 EREQRKLQE----KEQQRRLEDMQALRREEERRQAEREQ----EYKRKQLEEQRQSERLQ 466
Query: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPP 752
QL+ + L+Q+ Q Q+ + ++ G R P
Sbjct: 467 RQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP 503
Score = 43.1 bits (100), Expect = 0.002
Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 47/229 (20%)
Query: 377 NEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITP 436
+ ++ E+EE E E G E + + +EGE S I +PG L
Sbjct: 309 SRKKRGEKEETEYEYSGSEEEDDSHGEEGE------PSSIMNVPGESTL----------- 351
Query: 437 SPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYK 496
RR + R + + A +Q+Q+ +Q R+ + K
Sbjct: 352 -------------------RREFLRLQQENKSNSEALKQQQQLQQQQQ----RDPEAHIK 388
Query: 497 RMRRQHQKQLLAL-ESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRH----QAIGE 551
+ Q Q+++ E R R E ++ R QR+L+ + E + RR QA E
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 552 KEARAAQAEERKFQQHILGQQKKELAAL--LEAQKRTYKLRKEQLKEEL 598
+E + Q EE++ + + Q ++E A L L+ Q++ +L+K+Q ++ L
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 207 bits (526), Expect = 7e-53
Identities = 118/322 (36%), Positives = 176/322 (54%), Gaps = 16/322 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
DP F L+ +G G++G VY ARD SE+ A+K + Q +E+ L++
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQ---QEITILRE 67
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 142
RHPN + Y G YLR W+ ME+C G + + PL+E +IA V AL+GL +L
Sbjct: 68 CRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHL 127
Query: 143 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMD 198
HS IHRD+K N+LL+ G VKL DFG + + +A SF+GTPYWMAPEV
Sbjct: 128 HSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVER 187
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPVLQ-SGHWSEYFR 255
+G Y+ DVW+LGIT IEL E +PPLF+++ M AL ++++ + P L+ W++ F
Sbjct: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH 247
Query: 256 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKD------AVRELDNLQY 309
+F+ L K P+ RPT+E LL+H F ++ P ++ L+ + D + + + Y
Sbjct: 248 HFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETY 307
Query: 310 RKMKKILFQEAPNGPGAEAPEE 331
+ +GP P E
Sbjct: 308 DMFPDTIHSRGQHGPAERTPSE 329
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 206 bits (523), Expect = 1e-52
Identities = 153/437 (35%), Positives = 226/437 (51%), Gaps = 54/437 (12%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 AKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA ++ L+GLA+LH H++IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP---- 286
M AL+ I +N P L+S WS+ F +F++ CL K RP++E LLKH F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQ 297
Query: 287 -PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTL 345
+ D I RT+ E D +Y +E E PE+E E ++ G
Sbjct: 298 VRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGES 350
Query: 346 T-----------SLESSHSVPSMSISASSQSSSVNS-----LADASDNEEEEEEEEEEEE 389
T + E S ++ + Q LA+ E+++E+ E
Sbjct: 351 TLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE 410
Query: 390 EEEGPEAREMAMMQEGE 406
E++ E RE QE E
Sbjct: 411 EQQRRE-REARRQQERE 426
Score = 53.1 bits (126), Expect = 2e-06
Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 20/170 (11%)
Query: 538 EAEKLARRHQAIGEKEARAAQAEERKF---QQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E + RR Q + E++ R + +R+ +Q + QQK++ L E Q+R + R++Q
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+E+ + KR E R+KE+ ++ +AEEE + R+++Y Q + +R +
Sbjct: 425 REQ-RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL---- 479
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAE 704
L Q LL+E A+LL H +Q Q+ R++
Sbjct: 480 EVLQQQLLQEQ------------AMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 47.0 bits (110), Expect = 1e-04
Identities = 46/173 (26%), Positives = 83/173 (47%), Gaps = 25/173 (14%)
Query: 467 ATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQ--HQKQLLALESRLRGEREEHSARL 524
+T+R L +Q + ++ R+QL +++R Q +++QLLA R +R E
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLA----ERQKRIEQQKEQ 405
Query: 525 QRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQK 584
+R LE Q+ E+ ARR Q ++ R Q E+R+ ++ ++++E E +K
Sbjct: 406 RRRLEEQQ-----RREREARRQQE--REQRRREQEEKRRLEELERRRKEEEERRRAEEEK 458
Query: 585 RTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
R + +E ++ +L+E R E LQQ +E+A LL R+
Sbjct: 459 RRVEREQEYIRRQLEEEQ------------RHLEVLQQQLLQEQAMLLHDHRR 499
Score = 40.8 bits (94), Expect = 0.008
Identities = 61/265 (23%), Positives = 121/265 (45%), Gaps = 39/265 (14%)
Query: 498 MRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAA 557
M+R +QLL +R + E R+Q + + + R + GEK+
Sbjct: 275 MQRPSTEQLLK-HPFIRDQPNERQVRIQLK------------DHIDRTRKKRGEKDETEY 321
Query: 558 QAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQK 617
+ + ++ + +Q+ E ++++ + LR++ L+ + QEN + + + LL Q+
Sbjct: 322 EYSGSEEEEEEVPEQEGEPSSIVNVPGES-TLRRDFLRLQ-QENKERSEALRRQQLL-QE 378
Query: 618 EQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLEC 677
+QL++ Q E + LL +++ E Q Q +R L++ RE ++Q +++
Sbjct: 379 QQLRE-QEEYKRQLLAERQKRIEQQKEQRRR--------LEEQQRREREARRQQEREQR- 428
Query: 678 ALLLRQHEATR---ELELRQLQAVQRTRAELTRLQHQTE---LGNQLEYNKRR----EQE 727
R+ E R ELE R+ + +R RAE + + + E + QLE +R +Q+
Sbjct: 429 ---RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQ 485
Query: 728 LRQKHAAQVRQQPKSLKVRAGQRPP 752
L Q+ A + + + Q PP
Sbjct: 486 LLQEQAMLLHDHRRPHPQHSQQPPP 510
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/165 (23%), Positives = 76/165 (46%), Gaps = 24/165 (14%)
Query: 659 QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRT--RAELTRLQHQTELGN 716
+ LR D + Q Q++ E + LR+ + +E +LR+ + +R R++ Q E
Sbjct: 349 ESTLRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 717 QLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPC 776
+LE +RRE+E R++ + R++ + K R + ++
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEE-------------------LERRRKEE 448
Query: 777 SPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEES 821
+ A ++R + E+E + RR L +E LE QQ++L E++
Sbjct: 449 EERRRAEEEKRRVEREQEYI--RRQLEEEQRHLEVLQQQLLQEQA 491
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 206 bits (523), Expect = 1e-52
Identities = 153/437 (35%), Positives = 226/437 (51%), Gaps = 54/437 (12%)
Query: 7 AGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQS 66
A SL D D++ L DP +F + +G+G++G VY R V+ ++ AIK M + +
Sbjct: 7 AKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 NEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I E+ L+K H N Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 119
Query: 119 HK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--- 174
K L+E IA ++ L+GLA+LH H++IHRD+K N+LL+E VKL DFG ++
Sbjct: 120 TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 175 -IMAPANSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
+ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP---- 286
M AL+ I +N P L+S WS+ F +F++ CL K RP++E LLKH F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQ 297
Query: 287 -PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTL 345
+ D I RT+ E D +Y +E E PE+E E ++ G
Sbjct: 298 VRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGES 350
Query: 346 T-----------SLESSHSVPSMSISASSQSSSVNS-----LADASDNEEEEEEEEEEEE 389
T + E S ++ + Q LA+ E+++E+ E
Sbjct: 351 TLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE 410
Query: 390 EEEGPEAREMAMMQEGE 406
E++ E RE QE E
Sbjct: 411 EQQRRE-REARRQQERE 426
Score = 53.1 bits (126), Expect = 2e-06
Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 20/170 (11%)
Query: 538 EAEKLARRHQAIGEKEARAAQAEERKF---QQHILGQQKKELAALLEAQKRTYKLRKEQL 594
E + RR Q + E++ R + +R+ +Q + QQK++ L E Q+R + R++Q
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 595 KEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLAR 654
+E+ + KR E R+KE+ ++ +AEEE + R+++Y Q + +R +
Sbjct: 425 REQ-RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL---- 479
Query: 655 HSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAE 704
L Q LL+E A+LL H +Q Q+ R++
Sbjct: 480 EVLQQQLLQEQ------------AMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 47.0 bits (110), Expect = 1e-04
Identities = 46/173 (26%), Positives = 83/173 (47%), Gaps = 25/173 (14%)
Query: 467 ATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQ--HQKQLLALESRLRGEREEHSARL 524
+T+R L +Q + ++ R+QL +++R Q +++QLLA R +R E
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLA----ERQKRIEQQKEQ 405
Query: 525 QRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQK 584
+R LE Q+ E+ ARR Q ++ R Q E+R+ ++ ++++E E +K
Sbjct: 406 RRRLEEQQ-----RREREARRQQE--REQRRREQEEKRRLEELERRRKEEEERRRAEEEK 458
Query: 585 RTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQ 637
R + +E ++ +L+E R E LQQ +E+A LL R+
Sbjct: 459 RRVEREQEYIRRQLEEEQ------------RHLEVLQQQLLQEQAMLLHDHRR 499
Score = 40.8 bits (94), Expect = 0.008
Identities = 61/265 (23%), Positives = 121/265 (45%), Gaps = 39/265 (14%)
Query: 498 MRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAA 557
M+R +QLL +R + E R+Q + + + R + GEK+
Sbjct: 275 MQRPSTEQLLK-HPFIRDQPNERQVRIQLK------------DHIDRTRKKRGEKDETEY 321
Query: 558 QAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQK 617
+ + ++ + +Q+ E ++++ + LR++ L+ + QEN + + + LL Q+
Sbjct: 322 EYSGSEEEEEEVPEQEGEPSSIVNVPGES-TLRRDFLRLQ-QENKERSEALRRQQLL-QE 378
Query: 618 EQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLEC 677
+QL++ Q E + LL +++ E Q Q +R L++ RE ++Q +++
Sbjct: 379 QQLRE-QEEYKRQLLAERQKRIEQQKEQRRR--------LEEQQRREREARRQQEREQR- 428
Query: 678 ALLLRQHEATR---ELELRQLQAVQRTRAELTRLQHQTE---LGNQLEYNKRR----EQE 727
R+ E R ELE R+ + +R RAE + + + E + QLE +R +Q+
Sbjct: 429 ---RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQ 485
Query: 728 LRQKHAAQVRQQPKSLKVRAGQRPP 752
L Q+ A + + + Q PP
Sbjct: 486 LLQEQAMLLHDHRRPHPQHSQQPPP 510
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/165 (23%), Positives = 76/165 (46%), Gaps = 24/165 (14%)
Query: 659 QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRT--RAELTRLQHQTELGN 716
+ LR D + Q Q++ E + LR+ + +E +LR+ + +R R++ Q E
Sbjct: 349 ESTLRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 717 QLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPC 776
+LE +RRE+E R++ + R++ + K R + ++
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEE-------------------LERRRKEE 448
Query: 777 SPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEES 821
+ A ++R + E+E + RR L +E LE QQ++L E++
Sbjct: 449 EERRRAEEEKRRVEREQEYI--RRQLEEEQRHLEVLQQQLLQEQA 491
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 206 bits (523), Expect = 1e-52
Identities = 116/285 (40%), Positives = 175/285 (61%), Gaps = 12/285 (4%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
+P++ F ++ IG G++G VY AR+V E+ AIK + + E + + +E+ ++
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKL---EPGEDFAVVQQEIIMMKD 67
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGLAY 141
+HPN + Y G YLR W+ ME+C G S D+ V PL E++IA V+ LQGL Y
Sbjct: 68 CKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV-TGPLSELQIAYVSRETLQGLYY 126
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFG-SASI---MAPANSFVGTPYWMAPEVILAM 197
LHS +HRD+K NILL++ G VKL DFG SA I +A SF+GTPYWMAPEV
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186
Query: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPVLQSG-HWSEYF 254
+G Y+ D+W++GIT IELAE +PP+F+++ M AL+ + ++ + P L+ WS F
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246
Query: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKD 299
+FV L K P+ RPT+E LL+H FV + ++ ++L+ + +
Sbjct: 247 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNN 291
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 200 bits (509), Expect = 6e-51
Identities = 145/437 (33%), Positives = 220/437 (50%), Gaps = 48/437 (10%)
Query: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
+PE + + E+G G+FG VY A++ S + A K + +S E+ +D + E+ L
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---TKSEEELEDYMVEIDILAS 85
Query: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAY 141
HPN ++ + E+ W+++E+C G A D + + ++PL E +I V L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVIL-- 195
LH + +IHRD+KAGNIL + G +KL DFG + + +SF+GTPYWMAPEV++
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL-QSGHWSEYF 254
+ YD K DVWSLGIT IE+AE +PP +N M L IA++E P L Q WS F
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNF 265
Query: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKK 314
++F+ CL+K R T+ LL+H FV + I +LI K V E
Sbjct: 266 KDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP-IRELIAEAKAEVTE----------- 313
Query: 315 ILFQEAPNGPGAEAPEEEEEAE-----PYMHRAGTLTSLESSHS---------VPSMSIS 360
E +G + +EEEE E P RA + S+ SS + S+S
Sbjct: 314 ----EVEDG---KEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVS-E 365
Query: 361 ASSQSSSVNSLADASDNEE---EEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIH 417
+ +S+S + L NE+ +E E+ E+ E +A+ AM + + T +
Sbjct: 366 KTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENERE 425
Query: 418 RLPGSDNLYDDPYQPEI 434
+ P +NL D Q +
Sbjct: 426 KRPKLENLPDTEDQETV 442
Score = 76.6 bits (187), Expect = 1e-13
Identities = 64/287 (22%), Positives = 138/287 (48%), Gaps = 14/287 (4%)
Query: 468 TIRTASLVSRQIQEHEQDSALREQ-LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQR 526
++ T+ +V+ + E+ LR Q L + ++++ Q+ L S+L+ +RE+ R ++
Sbjct: 806 SVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQ 865
Query: 527 ELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRT 586
E+ +++ + E E L ++ + E+ + R + I G+Q+KEL+ +
Sbjct: 866 EMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELS-------KF 918
Query: 587 YKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQY 646
+ K + KE + E PK + E + R+KE+L Q Q +E +++Q+Q + ++
Sbjct: 919 QNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKI 978
Query: 647 KRKMLLARHSLDQDLLREDLNKKQTQKDLECAL--LLRQH-EATRELELRQLQAVQRTRA 703
++ +++++ L NK+Q + E A+ L +H + +L +QL+ +
Sbjct: 979 IQQQKAELANIERECLN---NKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQR 1035
Query: 704 ELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQR 750
+H+ E YN+R +EL+ + + + PK + A R
Sbjct: 1036 HQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTR 1082
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 199 bits (506), Expect = 1e-50
Identities = 148/443 (33%), Positives = 216/443 (48%), Gaps = 61/443 (13%)
Query: 12 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 71
DPD+ F DP + L+ +G G++G V+ ARD + ++VA+K + + ++
Sbjct: 5 DPDI----FNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM---EPDDDVS 57
Query: 72 DIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAA 130
+ KE+ L+ RH N + Y G YL W+ ME+C GS D+ +V L E++I+
Sbjct: 58 TLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGS-LSELQISY 116
Query: 131 VTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG-SASI---MAPANSFVGTP 186
V LQGLAYLHS IHRD+K NIL+++ G V+L DFG SA I +A SF+GTP
Sbjct: 117 VCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTP 176
Query: 187 YWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPV 244
YWMAPEV +G Y+ D+WSLGIT IELAE +PPLF+++ + L+ + ++ + P
Sbjct: 177 YWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPR 236
Query: 245 L-QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE-RPPTVIMDLIQRTKDAVR 302
L + G WS F NF+ L K P+ RP++ +L H+ V + +I+DL+ + K+ +
Sbjct: 237 LKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGK 296
Query: 303 ELDNLQYRKMKKILFQEAPNGPG-AEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISA 361
GP + +EE E P + R T SS +P
Sbjct: 297 --------------------GPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPD----- 331
Query: 362 SSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPG 421
AD E + E AR + + S S
Sbjct: 332 ----------ADCCRRHMEFRKLRGMETRPPANTAR-----LQPPRDLRSSSPRKQLSES 376
Query: 422 SDNLYDD---PYQPEITPSPLQP 441
SD+ YDD P E TP PL P
Sbjct: 377 SDDDYDDVDIPTPAEDTPPPLPP 399
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,650,844
Number of Sequences: 37866
Number of extensions: 3226629
Number of successful extensions: 56331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1155
Number of HSP's successfully gapped in prelim test: 1368
Number of HSP's that attempted gapping in prelim test: 28499
Number of HSP's gapped (non-prelim): 16326
length of query: 1235
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1121
effective length of database: 13,930,794
effective search space: 15616420074
effective search space used: 15616420074
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.